| 1921 | L | 106th Infantry | 0 | Brooklyn Evening HS (NY) | 30 | ? | |
| 1921 | L | 109th Field Artillery | 6 | Wyoming Seminary (PA) | 50 | ? | |
| 1921 | T | 1st Cavalry Division | 0 | El Paso HS (TX) | 0 | ? | |
| 1921 | L | 24th Infantry (GA) | 0 | Alabama St. | 7 | ? | |
| 1921 | T | 24th Infantry (GA) | 7 | Alabama St. | 7 | ? | |
| 1921 | L | 24th Infantry (GA) | 18 | Morehouse (GA) | 41 | ? | |
| 1921 | T | 24th Infantry (GA) | 0 | Morris Brown (GA) | 0 | ? | |
| 1921 | T | 9th Aerial Corps | 7 | Saint Martin's (WA) | 7 | ? | |
| 1921 | W | 9th Army Corps (WA) | 10 | Gonzaga (WA) | 7 | Fort Lewis, WA | |
| 1921 | W | 9th Army Corps (WA) | 28 | Puget Sound (WA) | 10 | Tacoma, WA | |
| 1921 | T | 9th Army Corps (WA) | 0 | San Francisco Olympic Club (CA) | 0 | San Francisco, CA | Score unknown |
| 1921 | L | 9th Army Corps (WA) | 7 | Washington | 24 | Seattle, WA | |
| 1921 | L | 9th Army Corps (WA) | 0 | Idaho | 6 | Moscow, ID | |
| 1921 | L | A.I.C. | 6 | Hinton HS (WV) | 21 | ? | |
| 1921 | W | Aberdeen American Legion (WA) | 13 | Saint Martin's (WA) | 0 | ? | |
| 1921 | W | Aberdeen HS (SD) | 21 | Clark HS (SD) | 6 | ? | |
| 1921 | L | Aberdeen HS (WA) | 0 | Chehalis HS (WA) | 8 | ? | |
| 1921 | L | Abilene Christian (TX) | 0 | Clarendon College (TX) | 7 | Clarendon, TX | |
| 1921 | L | Abilene Christian (TX) | 0 | Daniel Baker (TX) | 55 | Brownwood, TX | |
| 1921 | L | Abilene Christian (TX) | 0 | Howard Payne (TX) | 56 | Brownwood, TX | |
| 1921 | W | Abilene Christian (TX) | 7 | Midland College (TX) | 0 | Abilene, TX | |
| 1921 | L | Abilene Christian (TX) | 0 | West Texas A&M | 35 | Canyon, TX | |
| 1921 | L | Abilene Christian (TX) | 0 | Dallas (TX) | 20 | Abilene, TX | |
| 1921 | W | Abilene Christian (TX) | 37 | Meridian College (TX) | 0 | Meridian, TX | |
| 1921 | W | Abington HS (PA) | 21 | Abington HS Alumni (PA) | 0 | ? | |
| 1921 | W | Abington HS (PA) | 31 | Bristol HS (PA) | 0 | ? | |
| 1921 | W | Abington HS (PA) | 14 | Cheltenham HS (PA) | 0 | Abington, PA | |
| 1921 | W | Abington HS (PA) | 14 | Darby HS (PA) | 0 | ? | |
| 1921 | W | Abington HS (PA) | 7 | Lansdale HS (PA) | 0 | ? | |
| 1921 | W | Abington HS (PA) | 21 | Lower Merion HS (PA) | 7 | ? | |
| 1921 | W | Abington HS (PA) | 27 | Media HS (PA) | 0 | ? | |
| 1921 | W | Abington HS (PA) | 34 | Narberth HS (PA) | 0 | ? | |
| 1921 | L | Abington HS (PA) | 7 | Tredyffun-Easttown HS (PA) | 14 | ? | |
| 1921 | W | Abington HS (PA) | 26 | Woodbury HS (NJ) | 7 | ? | |
| 1921 | W | Abington HS (PA) | 26 | Woodbury HS (PA) | 7 | ? | |
| 1921 | L | Abington HS Alumni (PA) | 0 | Abington HS (PA) | 21 | ? | |
| 1921 | L | Ackerman HS (MS) | 0 | Amory HS (MS) | 13 | ? | |
| 1921 | W | Ackerman HS (MS) | 14 | Derma HS (MS) | 0 | ? | |
| 1921 | L | Ackerman HS (MS) | 0 | Louisville HS (MS) | 20 | ? | |
| 1921 | L | Ackerman HS (MS) | 0 | Noxapater HS (MS) | 13 | ? | |
| 1921 | W | Ackerman HS (MS) | 21 | Noxapater HS (MS) | 12 | ? | |
| 1921 | W | Ackerman HS (MS) | 21 | Pheba HS (MS) | 0 | ? | |
| 1921 | W | Ackerman HS (MS) | 77 | Starkville HS (MS) | 6 | ? | |
| 1921 | W | Ackerman HS (MS) | 28 | Wier | 9 | ? | |
| 1921 | L | Ada HS (MN) | 20 | Crookston HS (MN) | 22 | ? | |
| 1921 | L | Ada HS (MN) | 7 | Moorhead HS (MN) | 21 | ? | |
| 1921 | L | Ada HS (OH) | 0 | Mount Cory HS (OH) | 19 | ? | |
| 1921 | L | Ada HS (OH) | 0 | Toledo Waite HS (OH) | 162 | ? | |
| 1921 | L | Addison HS (MI) | 0 | Tecumseh HS (MI) | 7 | ? | |
| 1921 | L | Adelphi Academy (NY) | 6 | Barnard School (NY) | 16 | ? | |
| 1921 | W | Adelphi Academy (NY) | 13 | Freeport HS (NY) | 9 | ? | |
| 1921 | T | Adelphi Academy (NY) | 0 | Hempstead HS (NY) | 0 | ? | |
| 1921 | W | Adelphi Academy (NY) | 20 | Newark South Side HS (NJ) | 7 | ? | |
| 1921 | W | Adelphi Academy (NY) | 13 | Saint Francis Prep (NY) | 0 | ? | |
| 1921 | L | Adelphi Academy (NY) | 0 | Brooklyn Poly Prep School (NY) | 91 | Brooklyn, NY | Poly Field |
| 1921 | L | Adelphi Academy (NY) | 0 | Marquand School (NY) | 29 | Brooklyn, NY | Ozone Park |
| 1921 | T | Adelphia Social Club | 0 | Virginia Union | 0 | ? | |
| 1921 | L | Adrian (MI) | 7 | Assumption College (ON) | 13 | ? | |
| 1921 | L | Adrian (MI) | 0 | Hillsdale (MI) | 1 | ? | |
| 1921 | L | Adrian (MI) | 0 | Olivet (MI) | 7 | ? | |
| 1921 | W | Adrian (MI) | 1 | Toledo (OH) | 0 | Adrian, MI | Toledo Forfeits |
| 1921 | L | Adrian HS (MI) | 6 | Albion HS (MI) | 19 | ? | |
| 1921 | L | Adrian HS (MI) | 0 | Ann Arbor HS (MI) | 14 | ? | |
| 1921 | L | Adrian HS (MI) | 0 | Marshall HS (MI) | 31 | ? | |
| 1921 | L | Agnetian AC (CA) | 0 | California-Davis | 38 | ? | |
| 1921 | L | Agnetian AC (CA) | 0 | Santa Clara (CA) | 41 | Santa Clara, CA | |
| 1921 | L | Agnetian AC (CA) | 0 | Nevada | 54 | Reno, NV | |
| 1921 | W | Akron (OH) | 14 | Heidelberg (OH) | 0 | Akron, OH | |
| 1921 | W | Akron (OH) | 28 | Mount Union (OH) | 14 | Akron, OH | |
| 1921 | W | Akron (OH) | 26 | Ohio Northern | 7 | Akron, OH | |
| 1921 | W | Akron (OH) | 14 | Western Reserve (OH) | 7 | Akron, OH | |
| 1921 | L | Akron (OH) | 0 | Case Institute of Technology (OH) | 14 | Akron, OH | |
| 1921 | W | Akron (OH) | 35 | Muskingum (OH) | 8 | Akron, OH | |
| 1921 | L | Akron (OH) | 0 | Hiram (OH) | 6 | Hiram, OH | |
| 1921 | L | Akron (OH) | 0 | Wooster (OH) | 13 | Wooster, OH | |
| 1921 | L | Akron Central HS (OH) | 0 | Akron North HS (OH) | 2 | ? | |
| 1921 | L | Akron Central HS (OH) | 0 | Akron South HS (OH) | 3 | ? | |
| 1921 | L | Akron Central HS (OH) | 7 | Akron West HS (OH) | 12 | ? | |
| 1921 | W | Akron Central HS (OH) | 13 | Canton McKinley HS (OH) | 10 | ? | |
| 1921 | L | Akron Central HS (OH) | 0 | Fostoria HS (OH) | 39 | ? | |
| 1921 | L | Akron Central HS (OH) | 0 | Fostoria HS (OH) | 35 | ? | |
| 1921 | W | Akron Central HS (OH) | 28 | New Philadelphia HS (OH) | 7 | ? | |
| 1921 | W | Akron Central HS (OH) | 58 | Saint Vincent's HS | 0 | ? | |
| 1921 | L | Akron Central HS (OH) | 0 | Toledo Waite HS (OH) | 95 | ? | |
| 1921 | T | Akron Central HS (OH) | 0 | Youngstown Rayen HS (OH) | 0 | ? | |
| 1921 | L | Akron HS (CO) | 6 | Sterling HS (CO) | 25 | ? | |
| 1921 | L | Akron HS (CO) | 0 | Yuma County HS (CO) | 70 | ? | |
| 1921 | W | Akron North HS (OH) | 2 | Akron Central HS (OH) | 0 | ? | |
| 1921 | L | Akron Saint Vincent's HS (OH) | 0 | Warren HS (OH) | 44 | ? | |
| 1921 | W | Akron South HS (OH) | 3 | Akron Central HS (OH) | 0 | ? | |
| 1921 | W | Akron South HS (OH) | 49 | Alliance HS (OH) | 7 | ? | |
| 1921 | T | Akron South HS (OH) | 0 | Canton McKinley HS (OH) | 0 | ? | |
| 1921 | L | Akron South HS (OH) | 7 | Youngstown South HS (OH) | 13 | ? | |
| 1921 | W | Akron West HS (OH) | 12 | Akron Central HS (OH) | 7 | ? | |
| 1921 | L | Akron West HS (OH) | 10 | East Cleveland Shaw HS (OH) | 12 | ? | |
| 1921 | W | Alabama | 95 | Bryson (TN) | 0 | Tuscaloosa, AL | |
| 1921 | L | Alabama | 0 | Georgia | 22 | Atlanta, GA | |
| 1921 | T | Alabama | 7 | Louisiana St. | 7 | New Orleans, LA | |
| 1921 | T | Alabama | 7 | Mississippi St. | 7 | Birmingham, AL | |
| 1921 | W | Alabama | 34 | Samford (AL) | 14 | Tuscaloosa, AL | |
| 1921 | L | Alabama | 0 | Sewanee (TN) | 17 | Birmingham, AL | |
| 1921 | W | Alabama | 27 | Spring Hill (AL) | 7 | Tuscaloosa, AL | |
| 1921 | W | Alabama | 14 | Tulane (LA) | 7 | New Orleans, LA | |
| 1921 | L | Alabama | 0 | Vanderbilt (TN) | 14 | Birmingham, AL | |
| 1921 | W | Alabama | 55 | Marion Military Institute (AL) | 0 | Tuscaloosa, AL | |
| 1921 | L | Alabama | 2 | Florida | 9 | Tuscaloosa, AL | |
| 1921 | T | Alabama St. | 7 | 24th Infantry (GA) | 7 | ? | |
| 1921 | W | Alabama St. | 7 | 24th Infantry (GA) | 0 | ? | |
| 1921 | W | Alabama St. | 7 | Bethel | 0 | ? | |
| 1921 | T | Alabama St. | 7 | Miles (AL) | 7 | ? | |
| 1921 | L | Alabama St. | 20 | Talladega (AL) | 21 | Montgomery, AL | |
| 1921 | L | Alameda HS (CA) | 0 | Berkeley HS (CA) | 76 | ? | |
| 1921 | L | Alameda HS (CA) | 8 | Sacramento HS (CA) | 48 | ? | |
| 1921 | W | Alameda HS (CA) | 47 | San Francisco HS of Commerce (CA) | 0 | ? | |
| 1921 | L | Alameda HS (CA) | 0 | Santa Clara University HS (CA) | 32 | ? | |
| 1921 | L | Albany Academy (NY) | 0 | Albany HS (NY) | 7 | ? | |
| 1921 | L | Albany Academy (NY) | 0 | Berkshire HS | 6 | ? | |
| 1921 | L | Albany Academy (NY) | 0 | Gloversville HS (NY) | 7 | ? | |
| 1921 | T | Albany Academy (NY) | 0 | Hoosac School (NY) | 0 | ? | |
| 1921 | W | Albany Academy (NY) | 26 | Hoosick Falls HS (NY) | 0 | ? | |
| 1921 | W | Albany Academy (NY) | 9 | Watervliet HS (NY) | 0 | ? | |
| 1921 | W | Albany HS (NY) | 7 | Albany Academy (NY) | 0 | ? | |
| 1921 | T | Albany HS (NY) | 0 | Endicott Union HS (NY) | 0 | ? | |
| 1921 | L | Albany HS (NY) | 0 | Glens Falls HS (NY) | 7 | ? | |
| 1921 | W | Albany HS (NY) | 28 | Gloversville HS (NY) | 21 | ? | |
| 1921 | T | Albany HS (NY) | 7 | Kingston HS (NY) | 7 | ? | |
| 1921 | W | Albany HS (NY) | 34 | Kingston HS (NY) | 0 | ? | |
| 1921 | W | Albany HS (NY) | 21 | Troy HS (NY) | 0 | ? | |
| 1921 | W | Albany HS (NY) | 27 | Watervliet HS (NY) | 0 | ? | |
| 1921 | T | Albert Lea HS (MN) | 7 | Faribault HS (MN) | 7 | ? | |
| 1921 | L | Alberta (AB) | 17 | Calgary Bronks (AB) | 38 | Calgary, AB (Canada) | |
| 1921 | W | Alberta (AB) | 15 | Calgary Bronks (AB) | 0 | Edmonton, AB (Canada) | |
| 1921 | L | Alberta (AB) | 0 | Edmonton Eskimos (AB) | 41 | Edmonton, AB (Canada) | |
| 1921 | L | Alberta (AB) | 3 | Edmonton Eskimos (AB) | 35 | Edmonton, AB (Canada) | Diamond Park |
| 1921 | W | Albion (MI) | 27 | Eastern Michigan | 14 | Ypsilanti, MI | |
| 1921 | W | Albion (MI) | 14 | Hillsdale (MI) | 0 | Albion, MI | |
| 1921 | W | Albion (MI) | 14 | Notre Dame Freshmen (IN) | 7 | ? | |
| 1921 | W | Albion (MI) | 34 | Olivet (MI) | 7 | Olivet, MI | |
| 1921 | L | Albion (MI) | 9 | Western Michigan | 20 | Albion, MI | |
| 1921 | L | Albion (MI) | 0 | Kalamazoo (MI) | 7 | Kalamazoo, MI | |
| 1921 | W | Albion (MI) | 24 | Michigan St. | 7 | East Lansing, MI | |
| 1921 | W | Albion (MI) | 44 | Alma (MI) | 0 | Albion, MI | |
| 1921 | W | Albion HS (MI) | 19 | Adrian HS (MI) | 6 | ? | |
| 1921 | L | Albion HS (MI) | 7 | Ann Arbor HS (MI) | 19 | ? | |
| 1921 | L | Albion HS (MI) | 7 | Battle Creek HS (MI) | 14 | ? | |
| 1921 | W | Albion HS (MI) | 41 | Charlotte HS (MI) | 0 | ? | |
| 1921 | L | Albion HS (MI) | 7 | Coldwater HS (MI) | 12 | ? | |
| 1921 | W | Albion HS (MI) | 13 | Grand Rapids South HS (MI) | 0 | ? | |
| 1921 | L | Albion HS (MI) | 0 | Hillsdale HS (MI) | 21 | ? | |
| 1921 | W | Albion HS (MI) | 23 | Jackson HS (MI) | 14 | ? | |
| 1921 | L | Albion HS (MI) | 7 | Lansing HS (MI) | 26 | ? | |
| 1921 | T | Albion HS (MI) | 6 | Marshall HS (MI) | 6 | ? | |
| 1921 | L | Albright (PA) | 0 | Franklin & Marshall (PA) | 7 | Lancaster, PA | |
| 1921 | W | Albright (PA) | 41 | Juniata (PA) | 0 | Westminster, MD | |
| 1921 | W | Albright (PA) | 20 | McDaniel College (MD) | 7 | Westminster, MD | |
| 1921 | L | Albright (PA) | 7 | Muhlenberg (PA) | 15 | Myerstown, PA | |
| 1921 | W | Albright (PA) | 27 | Widener (PA) | 20 | Huntingdon, PA | |
| 1921 | L | Albright (PA) | 0 | Swarthmore (PA) | 28 | Swarthmore, PA | |
| 1921 | W | Albright (PA) | 21 | Susquehanna (PA) | 6 | Myerstown, PA | |
| 1921 | L | Albuquerque HS (NM) | 0 | El Paso HS (TX) | 65 | ? | |
| 1921 | L | Albuquerque HS (NM) | 0 | Roswell HS (NM) | 39 | ? | |
| 1921 | W | Alderson (WV) | 14 | Beckley Woodrow Wilson HS (WV) | 7 | Beckley, WV | |
| 1921 | W | Alderson (WV) | 6 | Oak Hill HS (WV) | 0 | ? | Alderson won - score unknown |
| 1921 | L | Alderson (WV) | 3 | West Virginia Tech | 42 | ? | |
| 1921 | W | Alexandria Episcopal HS (VA) | 28 | Alexandria HS (VA) | 0 | ? | |
| 1921 | W | Alexandria Episcopal HS (VA) | 30 | Augusta Military Academy (VA) | 0 | ? | |
| 1921 | W | Alexandria Episcopal HS (VA) | 21 | Baltimore Friends School (MD) | 0 | ? | |
| 1921 | L | Alexandria Episcopal HS (VA) | 6 | Gilman Country School (MD) | 14 | ? | |
| 1921 | W | Alexandria Episcopal HS (VA) | 47 | Randolph-Macon Academy (VA) | 0 | ? | |
| 1921 | W | Alexandria Episcopal HS (VA) | 34 | Shenandoah Military Academy (VA) | 0 | ? | |
| 1921 | L | Alexandria Episcopal HS (VA) | 0 | Washington Technical HS (DC) | 7 | ? | |
| 1921 | L | Alexandria Episcopal HS (VA) | 7 | Woodberry Forest School (VA) | 13 | ? | |
| 1921 | L | Alexandria HS (LA) | 2 | Baton Rouge HS (LA) | 12 | ? | |
| 1921 | W | Alexandria HS (MN) | 41 | Coleraine HS (MN) | 0 | ? | |
| 1921 | W | Alexandria HS (MN) | 28 | Hibbing HS (MN) | 0 | ? | |
| 1921 | W | Alexandria HS (MN) | 45 | Little Falls HS (MN) | 0 | ? | |
| 1921 | W | Alexandria HS (MN) | 46 | Moorhead HS (MN) | 0 | ? | |
| 1921 | W | Alexandria HS (MN) | 52 | Saint Cloud St. (MN) | 6 | ? | |
| 1921 | W | Alexandria HS (MN) | 20 | Saint John's (MN) | 14 | ? | |
| 1921 | W | Alexandria HS (MN) | 48 | Saint Thomas HS | 6 | ? | |
| 1921 | W | Alexandria HS (MN) | 80 | Wadena HS (MN) | 3 | ? | |
| 1921 | W | Alexandria HS (MN) | 20 | Worthington HS (MN) | 2 | ? | |
| 1921 | L | Alexandria HS (VA) | 0 | Alexandria Episcopal HS (VA) | 28 | ? | |
| 1921 | L | Alfred (NY) | 0 | Buffalo (NY) | 7 | Buffalo, NY | |
| 1921 | L | Alfred (NY) | 0 | Geneva (PA) | 21 | Alfred, NY | |
| 1921 | L | Alfred (NY) | 13 | Mansfield (PA) | 14 | Mansfield, PA | Disputed Game |
| 1921 | T | Alfred (NY) | 0 | Niagara (NY) | 0 | Alfred, NY | |
| 1921 | W | Alfred (NY) | 14 | Rochester Tech (NY) | 0 | ? | |
| 1921 | W | Alfred (NY) | 7 | Hamilton (NY) | 0 | Clinton, NY | |
| 1921 | T | Alfred (NY) | 0 | Allegheny (PA) | 0 | Meadville, PA | |
| 1921 | L | Alfred (NY) | 0 | Thiel (PA) | 13 | Alfred, NY | |
| 1921 | Alhambra HS (CA) | 6 | Mount Diablo HS (CA) | 21 | ? | ||
| 1921 | Alhambra HS (CA) | 7 | Santa Barbara HS (CA) | 48 | ? | ||
| 1921 | L | All Hallows Institute | 12 | Barnard School (NY) | 21 | ? | |
| 1921 | L | All Hallows Institute | 7 | Clason Military Academy (NY) | 21 | ? | |
| 1921 | T | All Hallows Institute | 0 | Saint Francis Prep (NY) | 0 | ? | |
| 1921 | L | Allegan HS (MI) | 14 | Grand Rapids Union HS (MI) | 28 | ? | |
| 1921 | L | Allegheny (PA) | 0 | Carnegie Mellon (PA) | 56 | Pittsburgh, PA | |
| 1921 | W | Allegheny (PA) | 14 | Geneva (PA) | 7 | Meadville, PA | |
| 1921 | L | Allegheny (PA) | 0 | Grove City (PA) | 7 | Meadville, PA | |
| 1921 | W | Allegheny (PA) | 7 | Westminster (PA) | 6 | New Wilmington, PA | |
| 1921 | L | Allegheny (PA) | 0 | Colgate (NY) | 14 | Hamilton, NY | |
| 1921 | W | Allegheny (PA) | 26 | Buffalo (NY) | 13 | Erie, PA | |
| 1921 | T | Allegheny (PA) | 0 | Alfred (NY) | 0 | Meadville, PA | |
| 1921 | L | Allegheny (PA) | 6 | Dickinson (PA) | 28 | Carlisle, PA | |
| 1921 | L | Allegheny Co. | 0 | Elkins HS (WV) | 48 | ? | |
| 1921 | L | Allen Academy (TX) | 0 | Sam Houston St. (TX) | 32 | Huntsville, TX | |
| 1921 | L | Allen Academy (TX) | 6 | San Marcos Baptist (TX) | 14 | ? | |
| 1921 | L | Allen Military School (MA) | 0 | Framingham HS (MA) | 12 | ? | |
| 1921 | L | Allen Military School (MA) | 0 | Middlesex School (MA) | 49 | ? | |
| 1921 | W | Allentown HS (PA) | 14 | Allentown HS Alumni (PA) | 0 | ? | |
| 1921 | W | Allentown HS (PA) | 14 | Bethlehem HS (PA) | 6 | ? | |
| 1921 | W | Allentown HS (PA) | 14 | Easton HS (PA) | 13 | ? | |
| 1921 | W | Allentown HS (PA) | 46 | Lansford HS (PA) | 0 | ? | |
| 1921 | W | Allentown HS (PA) | 46 | Norristown HS (PA) | 14 | ? | |
| 1921 | W | Allentown HS (PA) | 34 | Reading HS (PA) | 6 | ? | |
| 1921 | W | Allentown HS (PA) | 55 | Tamaqua HS (PA) | 0 | ? | |
| 1921 | W | Allentown HS (PA) | 75 | Wilson HS (PA) | 0 | ? | |
| 1921 | L | Allentown HS Alumni (PA) | 0 | Allentown HS (PA) | 14 | ? | |
| 1921 | L | Allentown Prep School (PA) | 0 | Blair Hall Academy (NJ) | 13 | ? | |
| 1921 | T | Allentown Prep School (PA) | 14 | Franklin & Marshall Academy (PA) | 14 | ? | |
| 1921 | W | Allentown Prep School (PA) | 3 | Lafayette Freshmen (PA) | 0 | ? | |
| 1921 | L | Allentown Prep School (PA) | 0 | Lancaster HS (PA) | 28 | ? | |
| 1921 | W | Allentown Prep School (PA) | 39 | Mining & Mechanical Institute (PA) | 0 | ? | |
| 1921 | W | Allentown Prep School (PA) | 14 | Muhlenberg Freshmen (PA) | 0 | ? | |
| 1921 | W | Allentown Prep School (PA) | 13 | Peddie Institute (NJ) | 7 | ? | |
| 1921 | W | Allentown Prep School (PA) | 26 | Schuylkill College (PA) | 6 | ? | |
| 1921 | L | Alliance (PA) | 0 | Slippery Rock (PA) | 39 | ? | |
| 1921 | L | Alliance HS (NE) | 0 | Ansley HS (NE) | 20 | ? | |
| 1921 | W | Alliance HS (NE) | 35 | Bayard HS (NE) | 14 | ? | |
| 1921 | W | Alliance HS (NE) | 12 | Broken Bow HS (NE) | 7 | ? | |
| 1921 | W | Alliance HS (NE) | 76 | Chadron HS (NE) | 0 | ? | |
| 1921 | W | Alliance HS (NE) | 68 | Chadron HS (NE) | 6 | ? | |
| 1921 | W | Alliance HS (NE) | 61 | Chappell HS (NE) | 6 | ? | |
| 1921 | W | Alliance HS (NE) | 42 | Cranford | 0 | ? | |
| 1921 | W | Alliance HS (NE) | 23 | Scottsbluff HS (NE) | 14 | ? | |
| 1921 | W | Alliance HS (NE) | 83 | Sidney HS (NE) | 0 | ? | |
| 1921 | L | Alliance HS (OH) | 7 | Akron South HS (OH) | 49 | ? | |
| 1921 | T | Alliance HS (OH) | 13 | Lisbon HS (OH) | 13 | ? | |
| 1921 | L | Alliance HS (OH) | 7 | Martins Ferry HS (OH) | 26 | ? | |
| 1921 | W | Alliance HS (OH) | 25 | Massillon HS (OH) | 0 | ? | |
| 1921 | L | Alliance HS (OH) | 6 | Salem HS (OH) | 14 | ? | |
| 1921 | L | Alliance HS (OH) | 0 | Warren HS (OH) | 7 | ? | |
| 1921 | W | Alliance HS (OH) | 26 | Wooster HS (OH) | 0 | ? | |
| 1921 | L | All-Stars | 0 | Elizabethtown HS (KY) | 33 | ? | |
| 1921 | L | Alma (MI) | 0 | Central Michigan | 28 | Alma, MI | |
| 1921 | W | Alma (MI) | 7 | Eastern Michigan | 0 | Ypsilanti, MI | |
| 1921 | W | Alma (MI) | 32 | Hope (MI) | 0 | ? | |
| 1921 | L | Alma (MI) | 0 | Kalamazoo (MI) | 15 | Alma, MI | |
| 1921 | L | Alma (MI) | 0 | Olivet (MI) | 21 | ? | |
| 1921 | L | Alma (MI) | 0 | Michigan St. | 28 | East Lansing, MI | |
| 1921 | L | Alma (MI) | 0 | Hillsdale (MI) | 14 | ? | |
| 1921 | T | Alma (MI) | 0 | Wayne St. (MI) | 0 | Detroit, MI | |
| 1921 | L | Alma (MI) | 0 | Albion (MI) | 44 | Albion, MI | |
| 1921 | L | Alma HS (MI) | 0 | Flint Central HS (MI) | 20 | ? | |
| 1921 | L | Alma HS (MI) | 0 | Saginaw East HS (MI) | 16 | ? | |
| 1921 | W | Alma HS (NE) | 48 | Holdrege HS (NE) | 7 | ? | |
| 1921 | W | Alma HS (NE) | 14 | Holdrege HS (NE) | 0 | ? | |
| 1921 | W | Alton HS (IL) | 21 | Jacksonville HS (IL) | 7 | ? | |
| 1921 | T | Alton HS (IL) | 0 | Webster Groves HS (MO) | 0 | ? | |
| 1921 | L | Altoona Apprentice School (PA) | 0 | Huntingdon HS (PA) | 57 | ? | |
| 1921 | L | Altoona HS (PA) | 26 | Clearfield HS (PA) | 27 | ? | |
| 1921 | L | Altoona HS (PA) | 0 | Huntingdon HS (PA) | 34 | ? | |
| 1921 | L | Altoona HS (PA) | 0 | Johnstown HS (PA) | 85 | ? | |
| 1921 | T | Altoona HS (PA) | 7 | Juniata JV (PA) | 7 | ? | |
| 1921 | L | Altoona HS (PA) | 0 | Lock Haven HS (PA) | 26 | ? | |
| 1921 | W | Altoona HS (PA) | 47 | Roaring Springs HS (PA) | 0 | ? | |
| 1921 | W | Altoona HS (PA) | 34 | Saint Francis (PA) | 0 | ? | |
| 1921 | L | Altoona HS (PA) | 6 | Williamsport HS (PA) | 39 | ? | |
| 1921 | W | Altoona HS (PA) | 1 | Windber HS (PA) | 0 | ? | |
| 1921 | T | Altus HS (OK) | 7 | Oklahoma City HS (OK) | 7 | ? | |
| 1921 | L | Ambler HS (PA) | 0 | Glassboro HS (NJ) | 21 | ? | |
| 1921 | L | Ambler HS (PA) | 0 | Moorestown HS (NJ) | 22 | ? | |
| 1921 | L | Ambler HS (PA) | 0 | Quakertown HS (PA) | 37 | ? | |
| 1921 | L | Ambridge HS (PA) | 0 | Monaca HS (PA) | 33 | ? | |
| 1921 | T | Ambridge HS (PA) | 0 | Sewickley HS (PA) | 0 | ? | |
| 1921 | T | American Legion | 6 | Clearfield HS (PA) | 6 | ? | |
| 1921 | L | American Legion | 0 | Glenwood HS (MN) | 7 | ? | |
| 1921 | L | American Legion | 0 | Hastings (NE) | 73 | ? | |
| 1921 | L | American Legion | 0 | Williston HS (ND) | 14 | ? | |
| 1921 | L | American Legion | 0 | Central Michigan | 28 | Mount Pleasant, MI | |
| 1921 | L | Americus Institute (GA) | 0 | Fort Valley St. (GA) | 5 | ? | |
| 1921 | W | Amesbury HS (MA) | 27 | Essex County Agriculture School (MA) | 7 | ? | |
| 1921 | W | Amesbury HS (MA) | 13 | Phillips Exeter Academy (NH) | 0 | ? | |
| 1921 | W | Amesbury HS (MA) | 14 | Wakefield HS (MA) | 0 | ? | |
| 1921 | W | Amherst (MA) | 20 | Hamilton (NY) | 0 | Amherst, MA | |
| 1921 | W | Amherst (MA) | 13 | Massachusetts | 0 | Amherst, MA | |
| 1921 | L | Amherst (MA) | 0 | Springfield (MA) | 26 | Springfield, MA | |
| 1921 | W | Amherst (MA) | 6 | Union (NY) | 0 | Schenectady, NY | |
| 1921 | W | Amherst (MA) | 9 | Columbia (NY) | 7 | New York, NY | |
| 1921 | T | Amherst (MA) | 3 | Wesleyan (CT) | 3 | Amherst, MA | |
| 1921 | T | Amherst (MA) | 0 | Tufts (MA) | 0 | Amherst, MA | |
| 1921 | L | Amherst (MA) | 0 | Williams (MA) | 20 | Williamstown, MA | |
| 1921 | W | Amory HS (MS) | 13 | Ackerman HS (MS) | 0 | ? | |
| 1921 | L | Anaheim HS (CA) | 0 | Santa Ana HS (CA) | 55 | ? | |
| 1921 | W | Ann Arbor HS (MI) | 14 | Adrian HS (MI) | 0 | ? | |
| 1921 | W | Ann Arbor HS (MI) | 19 | Albion HS (MI) | 7 | ? | |
| 1921 | W | Ann Arbor HS (MI) | 14 | Battle Creek HS (MI) | 0 | ? | |
| 1921 | W | Ann Arbor HS (MI) | 14 | Benton Harbor HS (MI) | 7 | ? | |
| 1921 | T | Ann Arbor HS (MI) | 7 | Jackson HS (MI) | 7 | ? | |
| 1921 | L | Ann Arbor HS (MI) | 7 | Kalamazoo HS (MI) | 13 | ? | |
| 1921 | T | Ann Arbor HS (MI) | 14 | Lansing HS (MI) | 14 | ? | |
| 1921 | W | Ann Arbor HS (MI) | 20 | Marshall HS (MI) | 0 | ? | |
| 1921 | T | Ann Arbor HS (MI) | 7 | Pontiac HS (MI) | 7 | ? | |
| 1921 | W | Ann Arbor HS (MI) | 12 | Wayne HS (MI) | 6 | ? | |
| 1921 | W | Ann Arbor HS (MI) | 58 | Ypsilanti HS (MI) | 0 | ? | |
| 1921 | L | Anna HS (IL) | 0 | Murphysboro HS (IL) | 48 | ? | |
| 1921 | L | Annapolis AC (MD) | 0 | Lincoln (PA) | 6 | Annapolis, MD | |
| 1921 | W | Annapolis HS (MD) | 6 | Mount Saint Joseph's College (MD) | 0 | ? | |
| 1921 | L | Annapolis HS (MD) | 0 | Severn School (MD) | 21 | ? | |
| 1921 | T | Anniston Independents (AL) | 0 | Jacksonville St. (AL) | 0 | ? | |
| 1921 | W | Anoka HS (MN) | 7 | Cambridge HS (MN) | 0 | ? | |
| 1921 | W | Anoka HS (MN) | 26 | Elk River HS (MN) | 7 | ? | |
| 1921 | L | Anoka HS (MN) | 0 | Milaca HS (MN) | 21 | ? | |
| 1921 | W | Anoka HS (MN) | 108 | Monticello HS (MN) | 0 | ? | |
| 1921 | W | Anoka HS (MN) | 54 | Princeton HS (MN) | 0 | ? | |
| 1921 | L | Anoka HS (MN) | 7 | Saint Cloud HS (MN) | 27 | ? | |
| 1921 | W | Ansley HS (NE) | 20 | Alliance HS (NE) | 0 | ? | |
| 1921 | L | Ansley HS (NE) | 19 | North Platte HS (NE) | 23 | ? | |
| 1921 | W | Ansonia HS (CT) | 27 | Ansonia HS Alumni (CT) | 0 | ? | |
| 1921 | W | Ansonia HS (CT) | 13 | Elgin HS (IL) | 0 | ? | |
| 1921 | W | Ansonia HS (CT) | 26 | Holyoke HS (MA) | 0 | ? | |
| 1921 | W | Ansonia HS (CT) | 28 | Meriden HS (CT) | 0 | ? | |
| 1921 | T | Ansonia HS (CT) | 0 | Naugatuck | 0 | ? | |
| 1921 | L | Ansonia HS (CT) | 13 | New Britain HS (CT) | 19 | ? | |
| 1921 | W | Ansonia HS (CT) | 28 | Norwalk HS (CT) | 0 | ? | |
| 1921 | W | Ansonia HS (CT) | 83 | Palmer HS (MA) | 0 | ? | |
| 1921 | W | Ansonia HS (CT) | 7 | Stamford HS (CT) | 0 | ? | |
| 1921 | W | Ansonia HS (CT) | 26 | Torrington HS (CT) | 6 | ? | |
| 1921 | W | Ansonia HS (CT) | 14 | West Haven HS (CT) | 0 | ? | |
| 1921 | L | Ansonia HS Alumni (CT) | 0 | Ansonia HS (CT) | 27 | ? | |
| 1921 | L | Anthony HS (KS) | 0 | Kingman HS (KS) | 59 | ? | |
| 1921 | L | Antioch (OH) | 0 | Cedarville (OH) | 2 | ? | |
| 1921 | W | Antioch (OH) | 7 | Cedarville (OH) | 0 | ? | |
| 1921 | L | Antioch (OH) | 0 | Wilmington (OH) | 49 | Yellow Springs, OH | |
| 1921 | L | Antioch American Legion (CA) | 0 | Santa Clara (CA) | 73 | ? | |
| 1921 | L | Antioch HS (CA) | 6 | Mount Diablo HS (CA) | 19 | ? | |
| 1921 | L | Antioch HS (CA) | 0 | San Rafael HS (CA) | 7 | ? | |
| 1921 | L | Apollo HS (PA) | 0 | Johnstown HS (PA) | 35 | ? | |
| 1921 | W | Aquinas College (MI) | 13 | Columbus South HS (OH) | 7 | ? | |
| 1921 | L | Ardmore HS (OK) | 14 | Sapulpa HS (OK) | 21 | ? | |
| 1921 | L | Arizona | 0 | Centre (KY) | 38 | San Diego, CA | San Diego E-W Christmas Classic |
| 1921 | W | Arizona | 24 | New Mexico | 0 | Albuquerque, NM | |
| 1921 | W | Arizona | 110 | New Mexico Military Institute | 0 | Tucson, AZ | |
| 1921 | W | Arizona | 75 | Phoenix Indian School (AZ) | 0 | Tucson, AZ | |
| 1921 | L | Arizona | 13 | Texas A&M | 17 | College Station, TX | |
| 1921 | W | Arizona | 74 | Texas-El Paso | 0 | Tucson, AZ | |
| 1921 | W | Arizona | 7 | Whittier (CA) | 0 | Tucson, AZ | |
| 1921 | W | Arizona | 31 | New Mexico St. | 0 | Las Cruces, NM | |
| 1921 | W | Arizona | 84 | Bisbee Legion (AZ) | 13 | Tucson, AZ | |
| 1921 | L | Arkadelphia HS (AR) | 0 | Little Rock HS (AR) | 7 | ? | |
| 1921 | W | Arkansas | 13 | Baylor (TX) | 12 | Fayetteville, AR | |
| 1921 | L | Arkansas | 0 | Oklahoma St. | 7 | Stillwater, OK | |
| 1921 | W | Arkansas | 28 | Ouachita Baptist (AR) | 0 | Little Rock, AR | |
| 1921 | W | Arkansas | 14 | Southern Methodist (TX) | 0 | Fort Smith, AR | |
| 1921 | L | Arkansas | 14 | Texas Christian | 19 | Fort Worth, TX | |
| 1921 | W | Arkansas | 28 | Hendrix (AR) | 0 | Fayetteville, AR | |
| 1921 | L | Arkansas | 7 | Louisiana St. | 10 | Shreveport, LA | |
| 1921 | W | Arkansas | 40 | Drury (MO) | 0 | Fayetteville, AR | |
| 1921 | T | Arkansas | 0 | Phillips (OK) | 0 | Fayetteville, AR | |
| 1921 | W | Arkansas Baptist | 26 | Arkansas-Pine Bluff | 0 | ? | |
| 1921 | W | Arkansas Baptist | 14 | Bishop (TX) | 7 | ? | |
| 1921 | W | Arkansas Baptist | 28 | Philander-Smith (AR) | 0 | ? | |
| 1921 | W | Arkansas Baptist | 52 | Shorter College (AR) | 0 | ? | |
| 1921 | T | Arkansas Baptist | 0 | Sloane HS | 0 | ? | |
| 1921 | W | Arkansas Freshmen | 13 | Southern Arkansas | 0 | Fayetteville, AR | |
| 1921 | W | Arkansas St. | 14 | Arkansas College | 7 | Jonesboro, AR | |
| 1921 | W | Arkansas St. | 7 | Bethel (TN) | 0 | ? | |
| 1921 | L | Arkansas St. | 7 | Central Arkansas | 13 | Jonesboro, AR | |
| 1921 | L | Arkansas St. | 0 | Little Rock College (AR) | 13 | Jonesboro, AR | |
| 1921 | T | Arkansas St. | 0 | Southeast Missouri St. | 0 | Cape Girardeau, MO | |
| 1921 | W | Arkansas St. | 19 | Memphis (TN) | 0 | Jonesboro, AR | |
| 1921 | W | Arkansas Tech | 67 | Central Arkansas | 0 | Conway, AR | |
| 1921 | W | Arkansas Tech | 21 | Henderson St. (AR) | 7 | Russellville, AR | |
| 1921 | W | Arkansas Tech | 21 | Little Rock College (AR) | 0 | Little Rock, AR | |
| 1921 | W | Arkansas Tech | 25 | Ozarks (AR) | 0 | Clarksville, AR | |
| 1921 | W | Arkansas Tech | 21 | Missouri St. | 0 | Russellville, AR | |
| 1921 | W | Arkansas Tech | 20 | Southern Arkansas | 0 | Russellville, AR | |
| 1921 | W | Arkansas Tech | 95 | Eastern Oklahoma St. | 0 | Russellville, AR | |
| 1921 | W | Arkansas-Monticello | 14 | Dermott HS (AR) | 7 | Dermott, AR | |
| 1921 | W | Arkansas-Monticello | 27 | Hendrix JV (AR) | 7 | Monticello, AR | |
| 1921 | L | Arkansas-Monticello | 0 | Louisiana Tech | 13 | Ruston, LA | |
| 1921 | W | Arkansas-Monticello | 52 | Fordyce HS (AR) | 7 | Monticello, AR | |
| 1921 | L | Arkansas-Monticello | 7 | Southern Arkansas | 13 | Magnolia, AR | |
| 1921 | L | Arkansas-Pine Bluff | 0 | Arkansas Baptist | 26 | ? | |
| 1921 | T | Arkansas-Pine Bluff | 0 | Philander-Smith (AR) | 0 | ? | |
| 1921 | W | Arkansas-Pine Bluff | 14 | Shorter College (AR) | 7 | ? | |
| 1921 | L | Arlington HS (MA) | 0 | Melrose HS (MA) | 3 | ? | |
| 1921 | L | Arlington HS (MA) | 0 | Wakefield HS (MA) | 7 | ? | |
| 1921 | L | Arlington HS (MA) | 7 | Woburn HS (MA) | 14 | ? | |
| 1921 | W | Arlington HS (OH) | 14 | Mount Blanchard HS (OH) | 0 | ? | |
| 1921 | L | Arlington HS (OH) | 6 | Mount Cory HS (OH) | 9 | ? | |
| 1921 | W | Arlington HS (WA) | 34 | Granite Falls HS (WA) | 7 | ? | |
| 1921 | L | Armstrong HS | 0 | Washington Dunbar HS (DC) | 6 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 0 | Baltimore Poly HS (MD) | 41 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 0 | Gilman Country School (MD) | 55 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 9 | Maryland Freshmen | 13 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 0 | McKinley Manual Training HS | 60 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 0 | Mount Saint Joseph's College (MD) | 3 | ? | |
| 1921 | W | Army & Navy Prep School (DC) | 6 | Mount Saint Mary's Prep | 0 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 7 | Severn School (MD) | 14 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 0 | Tome Institute (MD) | 20 | ? | |
| 1921 | L | Army & Navy Prep School (DC) | 0 | Washington Technical HS (DC) | 60 | ? | |
| 1921 | W | Army & Navy Prep School (DC) | 13 | Washington Western HS (DC) | 0 | ? | |
| 1921 | L | Army (NY) | 0 | Navy (MD) | 7 | New York, NY | |
| 1921 | W | Army (NY) | 53 | Susquehanna (PA) | 0 | West Point, NY | |
| 1921 | W | Army (NY) | 21 | Wabash (IN) | 0 | West Point, NY | |
| 1921 | L | Army (NY) | 7 | Yale (CT) | 14 | New Haven, CT | |
| 1921 | L | Army (NY) | 7 | New Hampshire | 10 | West Point, NY | |
| 1921 | W | Army (NY) | 28 | Springfield (MA) | 6 | West Point, NY | |
| 1921 | L | Army (NY) | 0 | Notre Dame (IN) | 28 | West Point, NY | |
| 1921 | W | Army (NY) | 33 | Lebanon Valley (PA) | 0 | West Point, NY | |
| 1921 | W | Army (NY) | 19 | Middlebury (VT) | 0 | West Point, NY | |
| 1921 | W | Army (NY) | 49 | Villanova (PA) | 0 | West Point, NY | |
| 1921 | L | Army-Navy Academy (CA) | 0 | San Diego St. (CA) | 12 | San Diego, CA | College Field |
| 1921 | L | Army-Navy Academy (CA) | 0 | San Diego St. (CA) | 6 | Pacific Beach, CA | Academy Field, Pacific Beach |
| 1921 | L | Artesia HS (NM) | 0 | Roswell HS (NM) | 20 | ? | |
| 1921 | L | Artesia HS (NM) | 0 | Roswell HS (NM) | 29 | ? | |
| 1921 | W | Asbury Park HS (NJ) | 13 | Atlantic City HS (NJ) | 0 | ? | |
| 1921 | W | Asbury Park HS (NJ) | 13 | Battin HS (NJ) | 7 | ? | |
| 1921 | W | Asbury Park HS (NJ) | 6 | Lakewood HS (NJ) | 0 | ? | |
| 1921 | W | Asbury Park HS (NJ) | 14 | Long Branch Chattle HS (NJ) | 0 | ? | |
| 1921 | L | Asbury Park HS (NJ) | 10 | Montclair HS (NJ) | 37 | ? | |
| 1921 | L | Asbury Park HS (NJ) | 0 | Neptune HS (NJ) | 6 | ? | |
| 1921 | L | Asbury Park HS (NJ) | 0 | Nutley HS (NJ) | 25 | ? | |
| 1921 | L | Asbury Park HS (NJ) | 3 | Rutherford HS (NJ) | 12 | ? | |
| 1921 | T | Asbury Park HS (NJ) | 7 | Trenton HS (NJ) | 7 | ? | |
| 1921 | W | Asheville HS (NC) | 21 | Asheville School (NC) | 19 | ? | |
| 1921 | T | Asheville HS (NC) | 14 | Bingham Military School (NC) | 14 | ? | |
| 1921 | W | Asheville HS (NC) | 7 | Blue Ridge (MD) | 0 | ? | |
| 1921 | W | Asheville HS (NC) | 34 | C.M. & N.A. | 6 | ? | |
| 1921 | L | Asheville HS (NC) | 9 | Knoxville HS (TN) | 21 | ? | |
| 1921 | W | Asheville HS (NC) | 72 | Lenoir-Rhyne (NC) | 0 | ? | |
| 1921 | W | Asheville HS (NC) | 19 | Mars Hill JC (NC) | 7 | ? | |
| 1921 | W | Asheville HS (NC) | 34 | Monroe HS (NC) | 0 | ? | |
| 1921 | L | Asheville HS (NC) | 6 | Shelby HS (NC) | 7 | ? | |
| 1921 | L | Asheville School (NC) | 19 | Asheville HS (NC) | 21 | ? | |
| 1921 | L | Asheville School (NC) | 2 | Weaver College (NC) | 7 | ? | |
| 1921 | L | Asheville School (NC) | 13 | Woodberry Forest School (VA) | 20 | ? | |
| 1921 | L | Ashland (OH) | 0 | Baldwin-Wallace (OH) | 36 | Berea, OH | |
| 1921 | W | Ashland (OH) | 27 | Bowling Green (OH) | 0 | Ashland, OH | |
| 1921 | W | Ashland (OH) | 7 | Kent St. (OH) | 0 | Kent, OH | |
| 1921 | L | Ashland (OH) | 0 | Thiel (PA) | 35 | ? | |
| 1921 | W | Ashland (OH) | 7 | Otterbein (OH) | 0 | ? | |
| 1921 | W | Ashland (OH) | 8 | Tiffin Junior Order Home (OH) | 0 | Ashland, OH | Heidelberg JV? |
| 1921 | L | Ashland HS (KY) | 0 | Ceredo-Kenova HS (WV) | 18 | ? | |
| 1921 | L | Ashland HS (KY) | 0 | Huntington HS (WV) | 28 | ? | |
| 1921 | W | Ashland HS (OR) | 61 | Grants Pass HS (OR) | 0 | ? | |
| 1921 | W | Ashland HS (OR) | 49 | Grants Pass HS (OR) | 6 | ? | |
| 1921 | L | Ashland HS (OR) | 7 | Klamath Falls HS (OR) | 17 | ? | |
| 1921 | W | Ashland HS (OR) | 23 | Klamath Falls HS (OR) | 7 | ? | |
| 1921 | W | Ashland HS (OR) | 38 | Lebanon HS (OR) | 7 | ? | |
| 1921 | W | Ashland HS (OR) | 54 | Medford HS (OR) | 7 | ? | |
| 1921 | W | Ashland HS (OR) | 12 | Medford HS (OR) | 0 | ? | |
| 1921 | W | Ashland HS (OR) | 54 | Roseburg HS (OR) | 0 | ? | |
| 1921 | L | Ashland HS (PA) | 14 | Minersville HS (PA) | 19 | ? | |
| 1921 | Ashland HS (WI) | 0 | Duluth Cathedral HS (MN) | 0 | ? | ||
| 1921 | Ashland HS (WI) | 7 | Superior HS (WI) | 7 | ? | ||
| 1921 | W | Ashley HS (OH) | 49 | Richmond HS (OH) | 0 | ? | |
| 1921 | L | Ashtabula HS (OH) | 14 | East Cleveland Shaw HS (OH) | 34 | ? | |
| 1921 | T | Ashtabula HS (OH) | 0 | Youngstown South HS (OH) | 0 | ? | |
| 1921 | W | Aspinwall HS (PA) | 2 | Duquesne HS (PA) | 0 | ? | |
| 1921 | W | Assumption College (ON) | 13 | Adrian (MI) | 7 | ? | |
| 1921 | L | Assumption College (ON) | 2 | Hillsdale (MI) | 7 | ? | |
| 1921 | L | Assumption College (ON) | 0 | Wayne St. (MI) | 26 | Windsor, ON (Canada) | |
| 1921 | L | Assumption College (ON) | 0 | Defiance (OH) | 1 | Defiance, OH | Assumption College Forfeits |
| 1921 | L | Assumption College (ON) | 0 | Eastern Michigan | 48 | Ypsilanti, MI | |
| 1921 | T | Assumption College (ON) | 14 | Olivet (MI) | 14 | ? | |
| 1921 | L | Atascadero HS (CA) | 0 | Cal Poly-San Luis Obispo | 31 | San Luis Obispo, CA | |
| 1921 | L | Athena HS (OR) | 7 | Pendleton HS (OR) | 49 | ? | |
| 1921 | W | Athens HS (GA) | 14 | Atlanta Boy's HS (GA) | 0 | ? | |
| 1921 | W | Athens HS (GA) | 42 | Dublin HS (GA) | 0 | ? | |
| 1921 | W | Athens HS (GA) | 34 | Gainesville HS (GA) | 0 | ? | |
| 1921 | W | Athens HS (GA) | 55 | Madison HS (GA) | 0 | ? | |
| 1921 | W | Athens HS (GA) | 13 | Richmond County Academy | 7 | ? | |
| 1921 | W | Athens HS (GA) | 55 | Toccoa HS (GA) | 0 | ? | |
| 1921 | L | Athens HS (GA) | 7 | University School | 21 | ? | |
| 1921 | W | Athens HS (GA) | 66 | Washington HS (GA) | 0 | ? | |
| 1921 | L | Athens HS (NY) | 3 | Cook Academy (NY) | 21 | ? | |
| 1921 | L | Athens HS (OH) | 0 | Huntington HS (WV) | 14 | ? | |
| 1921 | L | Athens HS (PA) | 20 | Cooke Academy | 33 | ? | |
| 1921 | W | Athens HS (PA) | 13 | Corning Free Academy (NY) | 0 | ? | |
| 1921 | L | Athens HS (PA) | 0 | Mansfield HS (PA) | 13 | ? | |
| 1921 | T | Athens HS (PA) | 7 | Sayre HS (PA) | 7 | ? | |
| 1921 | L | Athens HS (PA) | 0 | Sayre HS (PA) | 7 | ? | |
| 1921 | L | Athens HS (PA) | 0 | Towanda HS (PA) | 12 | ? | |
| 1921 | L | Athens HS (PA) | 0 | Towanda HS (PA) | 7 | ? | |
| 1921 | L | Athens HS (PA) | 0 | Tunkhannock HS (PA) | 26 | ? | |
| 1921 | L | Athens HS (PA) | 6 | Tunkhannock HS (PA) | 26 | ? | |
| 1921 | L | Athens HS (PA) | 0 | Waverly HS (PA) | 14 | ? | |
| 1921 | L | Athens HS (PA) | 0 | Waverly HS (PA) | 6 | ? | |
| 1921 | W | Atlanta (GA) | 19 | Clark Atlanta (GA) | 0 | ? | |
| 1921 | L | Atlanta (GA) | 0 | Morehouse (GA) | 7 | ? | |
| 1921 | L | Atlanta (GA) | 7 | Morris Brown (GA) | 19 | ? | |
| 1921 | L | Atlanta (GA) | 0 | Tuskegee (AL) | 13 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 0 | Athens HS (GA) | 14 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 7 | Atlanta Tech HS (GA) | 19 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 6 | Georgia Military Academy (GA) | 20 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 0 | Gordon (GA) | 41 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 12 | Gordon JV (GA) | 82 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 0 | Monroe Agricultural College (GA) | 14 | ? | |
| 1921 | W | Atlanta Boy's HS (GA) | 10 | Montgomery Sidney Lanier HS (AL) | 9 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 0 | Riverside Military Academy (GA) | 38 | ? | |
| 1921 | L | Atlanta Boy's HS (GA) | 7 | University School | 14 | ? | |
| 1921 | L | Atlanta HS (IL) | 0 | Lincoln HS (IL) | 27 | ? | |
| 1921 | L | Atlanta HS (TX) | 17 | Centenary (LA) | 20 | ? | |
| 1921 | W | Atlanta Tech HS (GA) | 19 | Atlanta Boy's HS (GA) | 7 | ? | |
| 1921 | W | Atlantic Christian (NC) | 14 | Wake Forest JV (NC) | 13 | ? | |
| 1921 | L | Atlantic Christian (NC) | 0 | Wilmington Light Infantry (NC) | 34 | ? | |
| 1921 | L | Atlantic City HS (NJ) | 0 | Asbury Park HS (NJ) | 13 | ? | |
| 1921 | W | Atlantic City HS (NJ) | 28 | Bridgeton HS (NJ) | 0 | ? | |
| 1921 | L | Atlantic City HS (NJ) | 0 | Camden HS (NJ) | 20 | ? | |
| 1921 | T | Atlantic City HS (NJ) | 6 | Collingswood HS (NJ) | 6 | ? | |
| 1921 | L | Atlantic City HS (NJ) | 0 | Delaware Valley (PA) | 33 | ? | |
| 1921 | L | Atlantic City HS (NJ) | 0 | La Salle Prep School (PA) | 12 | ? | |
| 1921 | L | Atlantic City HS (NJ) | 0 | Neptune HS (NJ) | 7 | ? | |
| 1921 | L | Atlantic City HS (NJ) | 0 | Trenton HS (NJ) | 27 | ? | |
| 1921 | L | Atlantic City HS (NJ) | 6 | Woodbury HS (NJ) | 14 | ? | |
| 1921 | L | Atlantic City HS JV (NJ) | 0 | Hammonton HS (NJ) | 35 | ? | |
| 1921 | L | Atlantic City HS JV (NJ) | 0 | Wildwood HS (NJ) | 6 | ? | |
| 1921 | L | Atlantic Highlands HS (NJ) | 6 | Red Bank HS (NJ) | 24 | ? | |
| 1921 | Attucks AC | 0 | Saint Paul's (VA) | 6 | ? | ||
| 1921 | W | Auburn (AL) | 56 | Clemson (SC) | 0 | Auburn, AL | |
| 1921 | W | Auburn (AL) | 14 | Fort Benning (GA) | 7 | Auburn, AL | |
| 1921 | L | Auburn (AL) | 0 | Georgia | 7 | Columbus, GA | |
| 1921 | L | Auburn (AL) | 0 | Georgia Tech | 14 | Atlanta, GA | |
| 1921 | W | Auburn (AL) | 49 | Marion Military Institute (AL) | 3 | ? | |
| 1921 | W | Auburn (AL) | 34 | Samford (AL) | 3 | Birmingham, AL | |
| 1921 | W | Auburn (AL) | 14 | Tulane (LA) | 0 | New Orleans, LA | |
| 1921 | W | Auburn (AL) | 44 | Spring Hill (AL) | 0 | Montgomery, AL | |
| 1921 | L | Auburn (AL) | 0 | Centre (KY) | 21 | Birmingham, AL | |
| 1921 | L | Auburn HS (NY) | 3 | Sherrill HS (NY) | 14 | ? | |
| 1921 | L | Auburn HS (NY) | 6 | Syracuse Central HS (NY) | 7 | ? | |
| 1921 | W | Auburn HS (NY) | 20 | Syracuse North HS (NY) | 7 | ? | |
| 1921 | W | Auburn JV (AL) | 49 | Marion Military Institute (AL) | 0 | ? | Auburn JV in question |
| 1921 | L | Augusta Military Academy (VA) | 0 | Alexandria Episcopal HS (VA) | 30 | ? | |
| 1921 | L | Augusta Military Academy (VA) | 0 | Fishburne Military School (VA) | 13 | ? | |
| 1921 | L | Augusta Military Academy (VA) | 0 | Staunton Military Academy (VA) | 27 | Staunton, VA | |
| 1921 | T | Augusta Military Academy (VA) | 0 | Woodberry Forest School (VA) | 0 | ? | |
| 1921 | W | Augustana (IL) | 14 | Illinois Wesleyan | 0 | Bloomington, IL | |
| 1921 | L | Augustana (IL) | 0 | Millikin (IL) | 28 | Rock Island, IL | |
| 1921 | W | Augustana (IL) | 19 | Monmouth (IL) | 7 | Monmouth, IL | |
| 1921 | L | Augustana (IL) | 0 | Wabash (IN) | 7 | Crawfordsville, IN | |
| 1921 | W | Augustana (IL) | 14 | Saint Ambrose (IA) | 0 | Rock Island, IL | |
| 1921 | W | Augustana (IL) | 28 | Parsons (IA) | 14 | Rock Island, IL | |
| 1921 | L | Augustana (IL) | 0 | Bradley (IL) | 13 | Peoria, IL | |
| 1921 | W | Augustana (SD) | 13 | Canton HS (SD) | 0 | ? | |
| 1921 | W | Augustana (SD) | 14 | Canton HS (SD) | 13 | ? | |
| 1921 | L | Augustana (SD) | 0 | Columbus (SD) | 76 | ? | |
| 1921 | T | Augustana (SD) | 7 | Flandreau Indian School (SD) | 7 | ? | |
| 1921 | L | Augustana (SD) | 6 | Dakota Wesleyan (SD) | 59 | Sioux Falls, SD | MacLean Field |
| 1921 | L | Aurora East HS (IL) | 0 | Elgin HS (IL) | 7 | ? | |
| 1921 | L | Aurora East HS (IL) | 2 | Freeport HS (IL) | 23 | ? | |
| 1921 | W | Aurora East HS (IL) | 13 | La Grange HS (IL) | 7 | ? | |
| 1921 | L | Aurora East HS (IL) | 7 | Mooseheart HS (IL) | 14 | ? | |
| 1921 | W | Aurora HS (MN) | 59 | Biwabik HS (MN) | 0 | ? | |
| 1921 | L | Aurora HS (MN) | 0 | Coleraine HS (MN) | 13 | ? | |
| 1921 | L | Aurora HS (MN) | 0 | Ely HS (MN) | 6 | ? | |
| 1921 | W | Aurora HS (MN) | 28 | Gilbert HS (MN) | 0 | ? | |
| 1921 | W | Aurora HS (MN) | 24 | Mountain Iron HS (MN) | 0 | ? | |
| 1921 | W | Aurora HS (MN) | 28 | Two Harbors HS (MN) | 14 | ? | |
| 1921 | L | Aurora West HS (IL) | 7 | Elgin HS (IL) | 10 | ? | |
| 1921 | L | Aurora West HS (IL) | 0 | Freeport HS (IL) | 70 | ? | |
| 1921 | L | Aurora West HS (IL) | 0 | Mooseheart HS (IL) | 6 | ? | |
| 1921 | W | Austin (TX) | 7 | Hardin-Simmons (TX) | 0 | Sherman, TX | |
| 1921 | W | Austin (TX) | 14 | Henderson St. (AR) | 7 | Sherman, TX | |
| 1921 | W | Austin (TX) | 34 | Southeastern Oklahoma St. | 0 | ? | |
| 1921 | W | Austin (TX) | 17 | Southern Methodist (TX) | 6 | Dallas, TX | |
| 1921 | W | Austin (TX) | 17 | Southwestern (TX) | 10 | Georgetown, TX | Snyder Field |
| 1921 | L | Austin (TX) | 3 | Trinity (TX) | 7 | Sherman, TX | |
| 1921 | L | Austin (TX) | 13 | Baylor (TX) | 17 | Sherman, TX | |
| 1921 | L | Austin (TX) | 14 | Howard Payne (TX) | 21 | Brownwood, TX | |
| 1921 | L | Austin (TX) | 0 | Texas | 60 | Austin, TX | |
| 1921 | W | Austin HS (MN) | 7 | Blooming Prairie HS (MN) | 0 | ? | |
| 1921 | L | Austin HS (MN) | 6 | Faribault HS (MN) | 26 | ? | |
| 1921 | W | Austin HS (MN) | 40 | Grand Meadow HS (MN) | 0 | ? | |
| 1921 | L | Austin HS (MN) | 0 | Osage HS (IA) | 21 | ? | |
| 1921 | L | Austin HS (MN) | 0 | Owatonna HS (MN) | 7 | ? | |
| 1921 | L | Austin HS (MN) | 0 | Winona HS (MN) | 23 | ? | |
| 1921 | W | Avalon HS (PA) | 9 | Ben Avon HS (PA) | 0 | ? | |
| 1921 | L | Avalon HS (PA) | 0 | Johnstown HS (PA) | 70 | ? | |
| 1921 | W | Avalon HS (PA) | 7 | Sewickley HS (PA) | 0 | ? | |
| 1921 | L | Avalon HS (PA) | 0 | Wilkinsburg HS (PA) | 12 | ? | |
| 1921 | W | Bailey Military Institute (SC) | 20 | Bingham Military School (NC) | 0 | ? | |
| 1921 | W | Bailey Military Institute (SC) | 14 | Porter Military Academy (SC) | 7 | ? | |
| 1921 | W | Baker (KS) | 13 | Kansas Wesleyan | 0 | Baldwin City, KS | |
| 1921 | W | Baker (KS) | 3 | McPherson (KS) | 0 | Baldwin City, KS | |
| 1921 | W | Baker (KS) | 28 | Ottawa (KS) | 7 | Ottawa, KS | |
| 1921 | T | Baker (KS) | 0 | Pittsburg St. (KS) | 0 | Baldwin City, KS | |
| 1921 | L | Baker (KS) | 16 | Washburn (KS) | 17 | Topeka, KS | |
| 1921 | W | Baker (KS) | 7 | William Jewell (MO) | 0 | ? | |
| 1921 | W | Baker (KS) | 33 | Saint Mary's (KS) | 3 | Baldwin City, KS | |
| 1921 | L | Baker (KS) | 0 | College of Emporia (KS) | 3 | Baldwin City, KS | |
| 1921 | L | Baker (KS) | 7 | Emporia St. (KS) | 13 | Emporia, KS | |
| 1921 | Baker HS (OR) | 0 | Pendleton HS (OR) | 13 | |||
| 1921 | T | Bakersfield HS (CA) | 0 | Berkeley HS (CA) | 0 | ? | |
| 1921 | W | Bakersfield HS (CA) | 27 | Dinuba HS (CA) | 0 | ? | |
| 1921 | W | Bakersfield HS (CA) | 34 | Fresno HS (CA) | 7 | ? | |
| 1921 | W | Baldwin-Wallace (OH) | 36 | Ashland (OH) | 0 | Berea, OH | |
| 1921 | L | Baldwin-Wallace (OH) | 13 | John Carroll (OH) | 19 | Berea, OH | |
| 1921 | T | Baldwin-Wallace (OH) | 0 | Muskingum (OH) | 0 | New Concord, OH | |
| 1921 | L | Baldwin-Wallace (OH) | 0 | Ohio | 35 | Athens, OH | |
| 1921 | L | Baldwin-Wallace (OH) | 0 | Wayne St. (MI) | 28 | Detroit, MI | |
| 1921 | W | Baldwin-Wallace (OH) | 14 | Westminster (PA) | 0 | New Wilmington, PA | |
| 1921 | L | Baldwin-Wallace (OH) | 35 | Toledo (OH) | 0 | Toledo, OH | Baldwin-Wallace Forfeits |
| 1921 | L | Baldwin-Wallace (OH) | 7 | Cincinnati (OH) | 17 | Cincinnati, OH | |
| 1921 | W | Baldwin-Wallace (OH) | 7 | Dayton (OH) | 0 | Berea, OH | |
| 1921 | L | Balloon Corps | 0 | Saint Martin's (WA) | 87 | ? | |
| 1921 | W | Baltimore City College (MD) | 13 | Baltimore Friends School (MD) | 7 | ? | |
| 1921 | L | Baltimore City College (MD) | 7 | Gilman Country School (MD) | 62 | ? | |
| 1921 | L | Baltimore City College (MD) | 0 | Mount Saint Joseph's College (MD) | 7 | ? | |
| 1921 | W | Baltimore City College (MD) | 7 | Severn School (MD) | 0 | ? | |
| 1921 | L | Baltimore City College (MD) | 0 | Washington Dunbar HS (DC) | 24 | ? | |
| 1921 | L | Baltimore Friends School (MD) | 0 | Alexandria Episcopal HS (VA) | 21 | ? | |
| 1921 | L | Baltimore Friends School (MD) | 7 | Baltimore City College (MD) | 13 | ? | |
| 1921 | W | Baltimore Friends School (MD) | 7 | Baltimore Poly Institute (MD) | 6 | ? | |
| 1921 | L | Baltimore Friends School (MD) | 14 | Gilman Country School (MD) | 49 | ? | |
| 1921 | W | Baltimore Friends School (MD) | 79 | Marston's University School (MD) | 0 | ? | |
| 1921 | L | Baltimore Friends School (MD) | 14 | McDonogh School (MD) | 21 | ? | |
| 1921 | W | Baltimore Friends School (MD) | 21 | Saint James Prep School (MD) | 0 | ? | |
| 1921 | W | Baltimore Poly HS (MD) | 41 | Army & Navy Prep School (DC) | 0 | ? | |
| 1921 | L | Baltimore Poly HS (MD) | 0 | Mercersburg Academy (PA) | 14 | ? | |
| 1921 | L | Baltimore Poly HS (MD) | 7 | Washington Central HS (DC) | 27 | ? | |
| 1921 | L | Baltimore Poly Institute (MD) | 6 | Baltimore Friends School (MD) | 7 | ? | |
| 1921 | L | Bangor HS (ME) | 0 | Portland HS (ME) | 7 | ? | |
| 1921 | L | Bangor HS (ME) | 6 | Portland HS (ME) | 14 | ? | |
| 1921 | L | Baraboo HS (WI) | 0 | Watertown HS (WI) | 7 | ? | |
| 1921 | L | Bardstown HS (KY) | 0 | Elizabethtown HS (KY) | 28 | ? | |
| 1921 | W | Barnard School (NY) | 16 | Adelphi Academy (NY) | 6 | ? | |
| 1921 | W | Barnard School (NY) | 21 | All Hallows Institute | 12 | ? | |
| 1921 | W | Barnard School (NY) | 53 | Massee Country | 0 | ? | |
| 1921 | L | Barnard School (NY) | 7 | Mount Pleasant HS (NY) | 19 | ? | |
| 1921 | L | Barnard School (NY) | 14 | Scarborough HS (NY) | 40 | ? | |
| 1921 | W | Barnard School (NY) | 20 | Trinity School (NY) | 6 | ? | |
| 1921 | L | Barry HS (IL) | 0 | Pittsfield HS (IL) | 102 | ? | |
| 1921 | L | Barry HS (IL) | 0 | Quincy HS (IL) | 56 | ? | |
| 1921 | W | Bartow Aviators (FL) | 19 | Stetson (FL) | 0 | ? | |
| 1921 | L | Batavia HS (IL) | 0 | Mooseheart HS (IL) | 75 | ? | |
| 1921 | L | Batavia HS (NY) | 0 | Tonawanda HS (NY) | 12 | ? | |
| 1921 | T | Bates (ME) | 7 | Colby (ME) | 7 | Waterville, ME | |
| 1921 | L | Bates (ME) | 0 | Holy Cross (MA) | 28 | Worcester, MA | |
| 1921 | T | Bates (ME) | 7 | Maine | 7 | Lewiston, ME | |
| 1921 | L | Bates (ME) | 0 | New Hampshire | 14 | Lewiston, ME | |
| 1921 | L | Bates (ME) | 0 | Yale (CT) | 28 | New Haven, CT | |
| 1921 | W | Bates (ME) | 14 | Tufts (MA) | 10 | Medford, MA | |
| 1921 | T | Bates (ME) | 0 | Massachusetts | 0 | Lewiston, ME | |
| 1921 | L | Bates University School (CA) | 0 | Santa Clara University HS (CA) | 35 | ? | |
| 1921 | W | Baton Rouge HS (LA) | 12 | Alexandria HS (LA) | 2 | ? | |
| 1921 | W | Baton Rouge HS (LA) | 84 | Hammond HS (LA) | 0 | ? | |
| 1921 | W | Baton Rouge HS (LA) | 55 | Houma HS (LA) | 0 | ? | |
| 1921 | W | Baton Rouge HS (LA) | 13 | Lake Charles HS (LA) | 0 | ? | |
| 1921 | W | Baton Rouge HS (LA) | 54 | Marksville HS (LA) | 0 | ? | |
| 1921 | T | Baton Rouge HS (LA) | 0 | Morgan City HS (LA) | 0 | ? | |
| 1921 | L | Baton Rouge HS (LA) | 6 | New Orleans HS (LA) | 21 | ? | |
| 1921 | L | Baton Rouge HS (LA) | 0 | Shreveport HS (LA) | 26 | ? | |
| 1921 | L | Battin HS (NJ) | 7 | Asbury Park HS (NJ) | 13 | ? | |
| 1921 | W | Battin HS (NJ) | 21 | Irvington HS (NJ) | 7 | ? | |
| 1921 | L | Battin HS (NJ) | 6 | Long Branch Chattle HS (NJ) | 13 | ? | |
| 1921 | L | Battin HS (NJ) | 12 | Montclair HS (NJ) | 16 | ? | |
| 1921 | L | Battin HS (NJ) | 6 | Neptune HS (NJ) | 9 | ? | |
| 1921 | L | Battin HS (NJ) | 0 | New Brunswick HS (NJ) | 9 | ? | |
| 1921 | T | Battin HS (NJ) | 0 | Newark East Side HS (NJ) | 0 | ? | |
| 1921 | W | Battin HS (NJ) | 21 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | L | Battin HS (NJ) | 7 | Plainfield HS (NJ) | 24 | ? | |
| 1921 | W | Battin HS (NJ) | 28 | Upsala (NJ) | 0 | ? | |
| 1921 | L | Battle Creek Eastern HS (MI) | 0 | Saginaw Arthur Hill HS (MI) | 21 | ? | |
| 1921 | W | Battle Creek HS (MI) | 14 | Albion HS (MI) | 7 | ? | |
| 1921 | L | Battle Creek HS (MI) | 0 | Ann Arbor HS (MI) | 14 | ? | |
| 1921 | L | Battle Creek HS (MI) | 0 | Lansing HS (MI) | 27 | ? | |
| 1921 | L | Battle Creek HS (MI) | 6 | Saginaw Arthur Hill HS (MI) | 14 | ? | |
| 1921 | L | Baxter Springs HS (KS) | 0 | Joplin HS (MO) | 41 | ? | |
| 1921 | L | Bay City Eastern HS (MI) | 6 | Saginaw East HS (MI) | 25 | ? | |
| 1921 | L | Bay City Western HS (MI) | 0 | Saginaw East HS (MI) | 52 | ? | |
| 1921 | L | Bay Minette HS (AL) | 0 | Jackson Agricultural School (AL) | 54 | ? | |
| 1921 | L | Bayard HS (NE) | 14 | Alliance HS (NE) | 35 | ? | |
| 1921 | L | Baylor (TX) | 12 | Arkansas | 13 | Fayetteville, AR | |
| 1921 | L | Baylor (TX) | 7 | Boston College (MA) | 23 | Dallas, TX | |
| 1921 | W | Baylor (TX) | 35 | John Tarleton College (TX) | 0 | Waco, TX | |
| 1921 | W | Baylor (TX) | 34 | Phillips (OK) | 6 | Waco, TX | |
| 1921 | W | Baylor (TX) | 28 | Southern Methodist (TX) | 0 | Waco, TX | |
| 1921 | W | Baylor (TX) | 16 | Southwestern (TX) | 0 | Waco, TX | |
| 1921 | W | Baylor (TX) | 17 | Austin (TX) | 13 | Sherman, TX | |
| 1921 | W | Baylor (TX) | 24 | Mississippi College | 0 | Dallas, TX | |
| 1921 | L | Baylor (TX) | 3 | Texas A&M | 14 | Waco, TX | |
| 1921 | W | Baylor (TX) | 17 | Rice (TX) | 14 | Waco, TX | |
| 1921 | W | Baylor (TX) | 21 | Hardin-Simmons (TX) | 0 | Waco, TX | |
| 1921 | L | Baylor Freshmen (TX) | 6 | John Tarleton College (TX) | 20 | ? | |
| 1921 | L | Baylor Freshmen (TX) | 9 | San Marcos Baptist (TX) | 24 | ? | |
| 1921 | W | Baylor Military Academy (TN) | 6 | Benton Polk County HS (TN) | 0 | ? | |
| 1921 | W | Baylor Military Academy (TN) | 7 | Chattanooga Central HS (TN) | 0 | ? | |
| 1921 | W | Baylor Military Academy (TN) | 45 | Jasper Marion County HS (TN) | 6 | ? | |
| 1921 | W | Baylor Military Academy (TN) | 35 | Knoxville HS (TN) | 12 | ? | |
| 1921 | L | Baylor Military Academy (TN) | 6 | McCallie School (TN) | 12 | ? | |
| 1921 | W | Baylor Military Academy (TN) | 34 | Montgomery Bell Academy (TN) | 6 | ? | |
| 1921 | W | Baylor Military Academy (TN) | 21 | Nashville Central HS (TN) | 0 | ? | |
| 1921 | L | Baylor Military Academy (TN) | 6 | Tennessee Military Institute | 13 | ? | |
| 1921 | W | Baylor Military Academy (TN) | 13 | Wills-Taylor School | 9 | ? | |
| 1921 | L | Bayonne HS (NJ) | 0 | Jersey City Dickinson HS (NJ) | 28 | ? | |
| 1921 | L | Bayonne HS (NJ) | 0 | Orange HS (NJ) | 28 | ? | |
| 1921 | L | Bayonne HS (NJ) | 0 | Plainfield HS (NJ) | 28 | ? | |
| 1921 | L | Bayonne HS (NJ) | 0 | Saint Peter's Prep (NJ) | 31 | ? | |
| 1921 | W | Beaumont HS (TX) | 33 | DeRidder HS (LA) | 0 | ? | |
| 1921 | W | Beaumont HS (TX) | 27 | Galveston Ball HS (TX) | 0 | ? | |
| 1921 | T | Beaumont HS (TX) | 0 | Houston Central HS (TX) | 0 | ? | |
| 1921 | W | Beaumont HS (TX) | 10 | Houston Heights HS (TX) | 0 | ? | |
| 1921 | T | Beaumont HS (TX) | 6 | Merryville HS (LA) | 6 | ? | |
| 1921 | L | Beaumont HS (TX) | 0 | Orange HS (TX) | 9 | ? | |
| 1921 | W | Beaumont HS (TX) | 26 | Silsbee HS (TX) | 0 | ? | |
| 1921 | W | Beaumont HS (TX) | 33 | Sour Lake HS (TX) | 0 | ? | |
| 1921 | W | Beaumont HS (TX) | 27 | South Park HS | 0 | ? | |
| 1921 | L | Beaumont HS (TX) | 0 | Waco HS (TX) | 63 | ? | |
| 1921 | L | Beaver City HS (NE) | 0 | Holdrege HS (NE) | 86 | ? | |
| 1921 | W | Beaver Falls HS (PA) | 6 | New Castle HS (PA) | 0 | ? | |
| 1921 | L | Beaver Falls HS (PA) | 6 | Rochester HS (PA) | 35 | ? | |
| 1921 | L | Beaver Falls HS (PA) | 0 | Sewickley HS (PA) | 3 | ? | |
| 1921 | W | Beaver Falls HS (PA) | 14 | Wilkinsburg HS (PA) | 0 | ? | |
| 1921 | L | Beaver HS (PA) | 6 | Monaca HS (PA) | 25 | ? | |
| 1921 | L | Beaver HS (PA) | 0 | Rochester HS (PA) | 61 | ? | |
| 1921 | L | Beaver HS (PA) | 0 | Sewickley HS (PA) | 14 | ? | |
| 1921 | L | Beckley Woodrow Wilson HS (WV) | 7 | Alderson (WV) | 14 | Beckley, WV | |
| 1921 | L | Belgrade HS (MT) | 0 | Park County HS (MT) | 60 | ? | |
| 1921 | L | Belington HS (WV) | 0 | Davis & Elkins JV (WV) | 13 | ? | |
| 1921 | L | Belington HS (WV) | 0 | Elkins HS (WV) | 34 | ? | |
| 1921 | L | Belington HS (WV) | 7 | Elkins HS (WV) | 48 | ? | |
| 1921 | W | Belington HS (WV) | 13 | Fairmont East Side HS (WV) | 0 | ? | |
| 1921 | L | Belington HS (WV) | 0 | Grafton HS (WV) | 42 | ? | |
| 1921 | L | Belington HS (WV) | 0 | Mannington HS (WV) | 34 | ? | |
| 1921 | W | Belington HS (WV) | 27 | Philippi HS (WV) | 0 | ? | |
| 1921 | W | Belington HS (WV) | 21 | Philippi HS (WV) | 0 | ? | |
| 1921 | W | Belington HS (WV) | 12 | Shinnston HS (WV) | 0 | ? | |
| 1921 | L | Belington HS (WV) | 0 | Shinnston HS (WV) | 13 | ? | |
| 1921 | W | Bellaire HS (OH) | 7 | Martins Ferry HS (OH) | 0 | ? | |
| 1921 | W | Bellaire HS (OH) | 33 | Sistersville HS (WV) | 0 | ? | |
| 1921 | W | Bellaire HS (OH) | 48 | Triadelphia HS (WV) | 0 | ? | |
| 1921 | W | Bellaire HS (OH) | 7 | Washington HS (PA) | 6 | ? | |
| 1921 | T | Bellaire HS (OH) | 0 | Wheeling HS (WV) | 0 | ? | |
| 1921 | L | Belle Fourche HS (SD) | 0 | Black Hills St. (SD) | 19 | ? | |
| 1921 | W | Belle Fourche HS (SD) | 16 | Black Hills St. JV (SD) | 0 | ? | |
| 1921 | W | Belle Fourche HS (SD) | 40 | Deadwood HS (SD) | 3 | ? | |
| 1921 | W | Belle Fourche HS (SD) | 28 | Deadwood HS (SD) | 7 | ? | |
| 1921 | L | Belle Fourche HS (SD) | 12 | Lead HS (SD) | 14 | ? | |
| 1921 | W | Belle Fourche HS (SD) | 7 | Lead HS (SD) | 0 | ? | |
| 1921 | L | Belle Fourche HS (SD) | 12 | Rapid City HS (SD) | 19 | ? | |
| 1921 | L | Belle Plaine HS (MN) | 0 | New Prague HS (MN) | 106 | ? | |
| 1921 | W | Bellefontaine HS (OH) | 7 | London HS (OH) | 6 | ? | |
| 1921 | T | Bellefonte Academy (PA) | 0 | Bucknell JV (PA) | 0 | ? | |
| 1921 | T | Bellefonte Academy (PA) | 0 | Carnegie Mellon JV (PA) | 0 | ? | |
| 1921 | W | Bellefonte Academy (PA) | 64 | Juniata (PA) | 0 | Huntingdon, PA | Juniata HS? |
| 1921 | L | Bellefonte Academy (PA) | 0 | Penn St. Freshmen | 13 | ? | |
| 1921 | L | Bellefonte Academy (PA) | 0 | Pittsburgh Freshmen (PA) | 28 | ? | |
| 1921 | T | Bellefonte Academy (PA) | 0 | Potomac School | 0 | ? | |
| 1921 | T | Bellefonte Academy (PA) | 6 | Wyoming Seminary (PA) | 6 | ? | |
| 1921 | L | Bellevue HS (OH) | 0 | Sandusky HS (OH) | 31 | ? | |
| 1921 | W | Bellevue HS (PA) | 20 | Ben Avon HS (PA) | 0 | ? | |
| 1921 | L | Bellevue HS (PA) | 0 | Shady Side Academy (PA) | 35 | ? | |
| 1921 | L | Bellwood HS (PA) | 6 | Curwensville HS (PA) | 38 | ? | |
| 1921 | L | Belmont HS (MA) | 0 | Dedham HS (MA) | 40 | ? | |
| 1921 | L | Beloit (WI) | 0 | Carleton (MN) | 42 | Northfield, MN | |
| 1921 | W | Beloit (WI) | 13 | Knox (IL) | 7 | Beloit, WI | |
| 1921 | L | Beloit (WI) | 0 | Lawrence (WI) | 36 | Appleton, WI | |
| 1921 | W | Beloit (WI) | 7 | Northwestern (IL) | 0 | Evanston, IL | |
| 1921 | W | Beloit (WI) | 16 | Ripon (WI) | 9 | Beloit, WI | |
| 1921 | T | Beloit (WI) | 0 | Northwestern (WI) | 0 | Watertown, WI | |
| 1921 | W | Beloit (WI) | 21 | Lake Forest (IL) | 14 | Lake Forest, IL | |
| 1921 | W | Beloit (WI) | 14 | Carroll (WI) | 7 | Beloit, WI | |
| 1921 | W | Beloit HS (WI) | 9 | Kenosha HS (WI) | 7 | ? | |
| 1921 | L | Belzoni HS (MS) | 0 | Greenville HS (MS) | 34 | ? | |
| 1921 | W | Bemidji HS (MN) | 19 | Thief River Falls HS (MN) | 0 | ? | |
| 1921 | L | Ben Avon HS (PA) | 0 | Avalon HS (PA) | 9 | ? | |
| 1921 | L | Ben Avon HS (PA) | 0 | Bellevue HS (PA) | 20 | ? | |
| 1921 | T | Ben Avon HS (PA) | 0 | Edgewood HS (PA) | 0 | ? | |
| 1921 | T | Ben Avon HS (PA) | 6 | Freedom HS (PA) | 6 | ? | |
| 1921 | L | Ben Avon HS (PA) | 0 | Knoxville HS (PA) | 32 | ? | |
| 1921 | L | Ben Avon HS (PA) | 0 | Munhall HS (PA) | 14 | ? | |
| 1921 | L | Ben Avon HS (PA) | 0 | Sewickley HS (PA) | 7 | ? | |
| 1921 | W | Ben Avon HS (PA) | 41 | Sharpsburg HS (PA) | 7 | ? | |
| 1921 | L | Benedict (SC) | 0 | Porter Military Academy (SC) | 37 | ? | |
| 1921 | W | Benedictine (IL) | 38 | Lafayette Club | 0 | ? | |
| 1921 | L | Benedictine (IL) | 0 | Mooseheart HS (IL) | 60 | ? | |
| 1921 | W | Benedictine (IL) | 22 | Northwestern Academy (IL) | 0 | ? | |
| 1921 | W | Benedictine (IL) | 54 | Northwestern Academy (IL) | 7 | ? | |
| 1921 | W | Benedictine (IL) | 103 | Palmer College of Chiropractic (IA) | 0 | ? | |
| 1921 | W | Benedictine (IL) | 40 | Pyramid AA (IL) | 0 | ? | |
| 1921 | L | Benedictine (IL) | 7 | Saint Joseph's (IN) | 20 | ? | |
| 1921 | W | Benedictine (IL) | 14 | Saint Joseph's (IN) | 6 | ? | |
| 1921 | W | Benedictine (KS) | 21 | Doane (NE) | 13 | Atchison, KS | |
| 1921 | W | Benedictine (KS) | 41 | Kansas School for the Deaf and Dumb | 6 | Atchison, KS | |
| 1921 | L | Benedictine (KS) | 0 | Missouri Wesleyan | 6 | Atchison, KS | |
| 1921 | L | Benedictine (KS) | 12 | Nebraska Wesleyan | 14 | ? | |
| 1921 | L | Benedictine (KS) | 0 | Ottawa (KS) | 14 | Atchison, KS | |
| 1921 | W | Benedictine (KS) | 35 | Rockhurst (MO) | 0 | ? | |
| 1921 | L | Benedictine (KS) | 14 | Chillicothe Business College (MO) | 19 | Atchison, KS | |
| 1921 | W | Benedictine (KS) | 28 | Graceland (IA) | 0 | Atchison, KS | |
| 1921 | L | Benedictine College (GA) | 0 | Porter Military Academy (SC) | 37 | ? | |
| 1921 | L | Bennington HS (NY) | 0 | Hoosac School (NY) | 7 | ? | |
| 1921 | L | Benson HS (MN) | 0 | Montevideo HS (MN) | 33 | ? | |
| 1921 | L | Benton Harbor HS (MI) | 7 | Ann Arbor HS (MI) | 14 | ? | |
| 1921 | L | Benton Harbor HS (MI) | 14 | Muskegon HS (MI) | 27 | ? | |
| 1921 | L | Benton Harbor HS (MI) | 0 | Saginaw Arthur Hill HS (MI) | 1 | ? | Benton Harbor HS Forfeits |
| 1921 | W | Benton HS (IL) | 27 | Chicago Carl Schurz HS (IL) | 3 | ? | |
| 1921 | L | Benton HS (IL) | 13 | Murphysboro HS (IL) | 35 | ? | |
| 1921 | W | Benton HS (TN) | 19 | Tennessee Military Institute | 0 | ? | |
| 1921 | L | Benton Polk County HS (TN) | 0 | Baylor Military Academy (TN) | 6 | ? | |
| 1921 | L | Bentonville HS (AR) | 12 | Rogers HS (AR) | 26 | ? | |
| 1921 | W | Bentonville HS (AR) | 19 | Rogers HS (AR) | 13 | ? | |
| 1921 | W | Berkeley HS (CA) | 76 | Alameda HS (CA) | 0 | ? | |
| 1921 | T | Berkeley HS (CA) | 0 | Bakersfield HS (CA) | 0 | ? | |
| 1921 | L | Berkeley HS (CA) | 7 | California Freshmen | 14 | ? | |
| 1921 | W | Berkeley HS (CA) | 81 | Freemont HS | 0 | ? | |
| 1921 | T | Berkeley HS (CA) | 0 | Kern County HS (CA) | 0 | ? | |
| 1921 | W | Berkeley HS (CA) | 55 | Oakland Tech (CA) | 0 | ? | |
| 1921 | W | Berkeley HS (CA) | 42 | Palo Alto HS (CA) | 0 | ? | |
| 1921 | W | Berkeley HS (CA) | 28 | Sacramento HS (CA) | 7 | ? | |
| 1921 | W | Berkeley HS (CA) | 49 | Sacramento HS (CA) | 14 | ? | |
| 1921 | W | Berkeley HS (CA) | 48 | Saint Mary's HS (CA) | 0 | ? | |
| 1921 | W | Berkeley HS (CA) | 20 | San Francisco Lowell Boys HS (CA) | 0 | ? | |
| 1921 | W | Berkeley HS (CA) | 83 | Santa Rosa HS (CA) | 0 | ? | |
| 1921 | L | Berkeley HS (CA) | 7 | Stanford Freshmen (CA) | 14 | ? | |
| 1921 | W | Berkshire HS | 6 | Albany Academy (NY) | 0 | ? | |
| 1921 | W | Bernards HS (NJ) | 34 | Bound Brook HS (NJ) | 0 | ? | |
| 1921 | L | Bernards HS (NJ) | 6 | Chatham HS (NJ) | 13 | ? | |
| 1921 | W | Bernards HS (NJ) | 19 | Chatham HS (NJ) | 13 | ? | |
| 1921 | W | Bernards HS (NJ) | 7 | Flemington HS (NJ) | 0 | ? | |
| 1921 | W | Bernards HS (NJ) | 55 | Roxbury HS (NJ) | 0 | ? | |
| 1921 | W | Bernards HS (NJ) | 13 | Somerville HS (NJ) | 6 | ? | |
| 1921 | W | Bernards HS (NJ) | 3 | South River HS (NJ) | 0 | ? | |
| 1921 | T | Bernards HS (NJ) | 0 | West Orange HS (NJ) | 0 | ? | |
| 1921 | W | Berwyn HS (PA) | 21 | Media HS (PA) | 0 | ? | |
| 1921 | W | Berwyn HS (PA) | 7 | West Chester HS (PA) | 6 | ? | |
| 1921 | W | Bethany (KS) | 20 | Chilocco Indian School (OK) | 0 | Lindsborg, KS | |
| 1921 | W | Bethany (KS) | 16 | Kansas Wesleyan | 6 | Salina, KS | |
| 1921 | L | Bethany (KS) | 7 | Southwestern (KS) | 10 | Lindsborg, KS | |
| 1921 | W | Bethany (KS) | 10 | Sterling (KS) | 0 | Sterling, KS | |
| 1921 | W | Bethany (KS) | 12 | Friends (KS) | 0 | Lindsborg, KS | |
| 1921 | L | Bethany (KS) | 0 | Fort Hays St. (KS) | 7 | Hays, KS | |
| 1921 | L | Bethany (KS) | 0 | Wichita St. (KS) | 10 | Wichita, KS | |
| 1921 | W | Bethany (KS) | 7 | McPherson (KS) | 6 | Lindsborg, KS | |
| 1921 | W | Bethany (WV) | 42 | Buffalo (NY) | 0 | Bethany, WV | |
| 1921 | W | Bethany (WV) | 78 | Dayton (OH) | 0 | Bethany, WV | |
| 1921 | L | Bethany (WV) | 0 | Georgetown (DC) | 13 | Washington, DC | |
| 1921 | L | Bethany (WV) | 0 | Navy (MD) | 21 | Annapolis, MD | |
| 1921 | L | Bethany (WV) | 0 | Washington & Jefferson (PA) | 14 | Bethany, WV | |
| 1921 | W | Bethany (WV) | 67 | West Virginia Wesleyan | 0 | Wheeling, WV | |
| 1921 | W | Bethany (WV) | 28 | Marietta (OH) | 7 | Marietta, OH | |
| 1921 | W | Bethany (WV) | 14 | Grove City (PA) | 0 | Grove City, PA | |
| 1921 | W | Bethany (WV) | 13 | Ohio | 0 | Bethany, WV | High School field |
| 1921 | L | Bethany (WV) | 12 | Carnegie Mellon (PA) | 21 | Pittsburgh, PA | Plaid Field |
| 1921 | W | Bethany JV (WV) | 6 | Fairmont St. (WV) | 0 | ? | |
| 1921 | L | Bethel | 0 | Alabama St. | 7 | ? | |
| 1921 | W | Bethel (KY) | 16 | Bryson (TN) | 0 | ? | |
| 1921 | W | Bethel (KY) | 14 | Cumberland (TN) | 0 | ? | |
| 1921 | W | Bethel (KY) | 42 | Hodgenville AC (KY) | 0 | ? | |
| 1921 | T | Bethel (KY) | 0 | Louisville (KY) | 0 | Russellville, KY | |
| 1921 | T | Bethel (KY) | 7 | Western Kentucky | 7 | ? | |
| 1921 | L | Bethel (KY) | 0 | Union (TN) | 14 | ? | |
| 1921 | W | Bethel (KY) | 26 | Western Kentucky | 0 | ? | |
| 1921 | L | Bethel (TN) | 0 | Arkansas St. | 7 | ? | |
| 1921 | L | Bethel Academy | 7 | Phalen Luther Seminary (MN) | 9 | ? | |
| 1921 | T | Bethel Academy | 7 | Phalen Luther Seminary (MN) | 7 | ? | |
| 1921 | L | Bethlehem HS (PA) | 6 | Allentown HS (PA) | 14 | ? | |
| 1921 | L | Bethlehem HS (PA) | 21 | Harrisburg Tech HS (PA) | 63 | ? | |
| 1921 | W | Bethlehem HS (PA) | 76 | Lansford HS (PA) | 0 | ? | |
| 1921 | W | Bethlehem HS (PA) | 45 | Mining & Mechanical Institute (PA) | 0 | ? | |
| 1921 | W | Bethlehem HS (PA) | 14 | Morristown HS (NJ) | 0 | ? | |
| 1921 | W | Bethlehem HS (PA) | 14 | Norristown HS (PA) | 0 | ? | |
| 1921 | W | Bethlehem HS (PA) | 82 | Pen Argyl HS (PA) | 0 | ? | |
| 1921 | W | Bethlehem HS (PA) | 17 | Phoenixville HS (PA) | 2 | ? | |
| 1921 | L | Bethlehem HS (PA) | 24 | Steelton HS (PA) | 30 | ? | |
| 1921 | W | Bethlehem HS (PA) | 37 | Tamaqua HS (PA) | 0 | ? | |
| 1921 | W | Bethlehem HS (PA) | 63 | Wilson HS (PA) | 0 | ? | |
| 1921 | L | Bethlehem Prep School (PA) | 0 | Blair Hall Academy (NJ) | 13 | ? | |
| 1921 | T | Bethlehem Prep School (PA) | 7 | East Stroudsburg (PA) | 7 | ? | |
| 1921 | W | Bethlehem Prep School (PA) | 7 | Pennington Seminary (NJ) | 0 | ? | |
| 1921 | L | Bethlehem Prep School (PA) | 6 | Perkiomen Seminary (PA) | 15 | ? | |
| 1921 | L | Bethlehem Prep School (PA) | 2 | Wyoming Seminary (PA) | 42 | ? | |
| 1921 | W | Beverly HS (MA) | 21 | Gloucester HS (MA) | 0 | ? | |
| 1921 | L | Beverly HS (MA) | 7 | Marblehead HS (MA) | 13 | ? | |
| 1921 | L | Beverly HS (MA) | 0 | Peabody HS (MA) | 7 | ? | |
| 1921 | W | Beverly HS (MA) | 7 | Revere HS (MA) | 0 | ? | |
| 1921 | L | Big Horn Academy (WY) | 0 | Sheridan HS (WY) | 28 | ? | |
| 1921 | L | Bigheart HS | 0 | Collinsville HS (OK) | 27 | ? | |
| 1921 | L | Billings HS (MT) | 6 | Sheridan HS (WY) | 21 | ? | |
| 1921 | L | Billings Poly (MT) | 0 | Carroll (MT) | 12 | ? | |
| 1921 | L | Billings Poly (MT) | 0 | Carroll (MT) | 13 | ? | |
| 1921 | L | Billings Poly (MT) | 0 | Montana Wesleyan | 98 | Helena, MT | |
| 1921 | L | Billings Poly (MT) | 0 | Montana Tech | 55 | Billings, MT | |
| 1921 | T | Bingham Military School (NC) | 14 | Asheville HS (NC) | 14 | ? | |
| 1921 | L | Bingham Military School (NC) | 0 | Bailey Military Institute (SC) | 20 | ? | |
| 1921 | W | Bingham Military School (NC) | 35 | Blue Ridge (MD) | 7 | ? | |
| 1921 | W | Bingham Military School (NC) | 13 | C.M.N.A. | 7 | ? | |
| 1921 | L | Bingham Military School (NC) | 0 | Carson-Newman (TN) | 7 | ? | |
| 1921 | L | Bingham Military School (NC) | 7 | Charlotte HS | 20 | ? | |
| 1921 | W | Bingham Military School (NC) | 55 | Mars Hill JC (NC) | 0 | ? | |
| 1921 | W | Bingham Military School (NC) | 20 | North Carolina Freshmen | 6 | ? | |
| 1921 | L | Bingham Military School (NC) | 14 | Weaver College (NC) | 21 | Asheville, NC | |
| 1921 | W | Binghamton Central HS (NY) | 27 | Corning Free Academy (NY) | 0 | ? | |
| 1921 | W | Binghamton Central HS (NY) | 49 | Elmira Free Academy (NY) | 0 | ? | |
| 1921 | W | Binghamton Central HS (NY) | 10 | Endicott Union HS (NY) | 0 | ? | |
| 1921 | L | Binghamton Central HS (NY) | 0 | Geneva HS (NY) | 1 | ? | |
| 1921 | L | Binghamton Central HS (NY) | 0 | Ithaca HS (NY) | 14 | ? | |
| 1921 | W | Binghamton Central HS (NY) | 35 | Newburgh Free Academy (NY) | 0 | ? | |
| 1921 | W | Binghamton Central HS (NY) | 14 | Utica Free Academy (NY) | 0 | ? | |
| 1921 | W | Binghamton Central HS (NY) | 20 | Walton HS (NY) | 0 | ? | |
| 1921 | W | Binghamton Central HS (NY) | 41 | Watertown HS (NY) | 0 | ? | |
| 1921 | L | Birmingham HS (MI) | 0 | Detroit Northeastern HS (MI) | 19 | ? | |
| 1921 | W | Birmingham-Southern (AL) | 19 | Marion Military Institute (AL) | 0 | Birmingham, AL | |
| 1921 | L | Birmingham-Southern (AL) | 0 | Mercer (GA) | 20 | Macon, GA | |
| 1921 | L | Birmingham-Southern (AL) | 6 | Mississippi College | 27 | Birmingham, AL | |
| 1921 | L | Birmingham-Southern (AL) | 0 | Rollins (FL) | 3 | Tampa, FL | |
| 1921 | W | Birmingham-Southern (AL) | 16 | Samford (AL) | 14 | Birmingham, AL | |
| 1921 | L | Birmingham-Southern (AL) | 7 | Mississippi St. | 20 | Starkville, MS | |
| 1921 | T | Birmingham-Southern (AL) | 7 | Millsaps (MS) | 7 | Jackson, MS | |
| 1921 | W | Birmingham-Southern (AL) | 38 | Rhodes (TN) | 6 | Birmingham, AL | |
| 1921 | W | Birmingham-Southern (AL) | 14 | Tennessee-Chattanooga | 7 | Birmingham, AL | |
| 1921 | L | Bisbee Legion (AZ) | 13 | Arizona | 84 | Tucson, AZ | |
| 1921 | L | Bishop (TX) | 7 | Arkansas Baptist | 14 | ? | |
| 1921 | W | Bishop (TX) | 21 | Southern (LA) | 12 | ? | |
| 1921 | T | Bishop HS (CA) | 0 | Bishop AC (CA) | 0 | ? | |
| 1921 | W | Bishop HS (CA) | 29 | Bishop AC (CA) | 0 | ? | |
| 1921 | W | Bishop HS (CA) | 21 | Bishop HS Alumni (CA) | 0 | ? | |
| 1921 | W | Bishop HS (CA) | 16 | Bishop Independents (CA) | 10 | ? | |
| 1921 | W | Bishop HS (CA) | 24 | Bishop Independents (CA) | 0 | ? | |
| 1921 | T | Bishop HS (CA) | 7 | Reno HS (NV) | 7 | ? | |
| 1921 | T | Bishop HS (CA) | 7 | Round Valley Independents (CA) | 7 | ? | |
| 1921 | W | Bishop HS (CA) | 36 | Round Valley Independents (CA) | 0 | ? | |
| 1921 | L | Bishop HS Alumni (CA) | 0 | Bishop HS (CA) | 21 | ? | |
| 1921 | L | Bishop Independents (CA) | 10 | Bishop HS (CA) | 16 | ? | |
| 1921 | L | Bishop Independents (CA) | 0 | Bishop HS (CA) | 24 | ? | |
| 1921 | L | Biwabik HS (MN) | 0 | Aurora HS (MN) | 59 | ? | |
| 1921 | W | Black Hills St. (SD) | 19 | Belle Fourche HS (SD) | 0 | ? | |
| 1921 | L | Black Hills St. (SD) | 6 | Chadron St. (NE) | 7 | ? | |
| 1921 | L | Black Hills St. (SD) | 0 | Lead HS (SD) | 13 | ? | |
| 1921 | W | Black Hills St. (SD) | 13 | South Dakota Tech | 6 | Rapid City, SD | |
| 1921 | W | Black Hills St. (SD) | 7 | South Dakota Tech | 6 | Rapid City, SD | |
| 1921 | L | Black Hills St. (SD) | 0 | Chadron St. (NE) | 6 | Deadwood, SD | |
| 1921 | L | Black Hills St. (SD) | 14 | Montana Tech | 23 | Lead, SD | |
| 1921 | L | Black Hills St. JV (SD) | 0 | Belle Fourche HS (SD) | 16 | ? | |
| 1921 | L | Blackburn (IL) | 6 | Eastern Illinois | 59 | Charleston, IL | |
| 1921 | L | Blackburn (IL) | 0 | Illinois College | 87 | Jacksonville, IL | |
| 1921 | L | Blackburn (IL) | 0 | Illinois Wesleyan | 6 | Bloomington, IL | |
| 1921 | L | Blackburn (IL) | 0 | McKendree (IL) | 46 | ? | |
| 1921 | L | Blackburn (IL) | 13 | Shurtleff (IL) | 35 | Carlinville, IL | |
| 1921 | L | Blackburn (IL) | 0 | Illinois St. | 74 | Carlinville, IL | |
| 1921 | L | Blackfoot HS (ID) | 7 | Filer HS (ID) | 27 | ? | |
| 1921 | L | Blackfoot HS (ID) | 0 | Idaho St. | 71 | Pocatello, ID | |
| 1921 | L | Blacklick | 0 | Indiana (PA) | 7 | Indiana, PA | |
| 1921 | W | Blacksburg HS (VA) | 7 | Concord (WV) | 0 | ? | |
| 1921 | L | Blacksburg HS (VA) | 6 | Roanoke HS (VA) | 13 | ? | |
| 1921 | T | Blacksburg HS (VA) | 7 | Salem HS (VA) | 7 | ? | |
| 1921 | W | Blackstone Military Academy (VA) | 33 | Chatham Training School (VA) | 12 | ? | |
| 1921 | W | Blackstone Military Academy (VA) | 19 | Fork Union Military Academy (VA) | 0 | ? | |
| 1921 | W | Blair Hall (NJ) | 13 | Allentown Prep School (PA) | 0 | ? | |
| 1921 | W | Blair Hall (NJ) | 13 | Bethlehem Prep School (PA) | 0 | ? | |
| 1921 | W | Blair Hall (NJ) | 14 | Lafayette Freshmen (PA) | 7 | ? | |
| 1921 | W | Blair Hall (NJ) | 26 | Newton HS (NJ) | 7 | ? | |
| 1921 | T | Blair Hall (NJ) | 0 | Peddie Institute (NJ) | 0 | ? | |
| 1921 | T | Blair Hall (NJ) | 0 | Pennington Seminary (NJ) | 0 | ? | |
| 1921 | L | Blair Hall (NJ) | 0 | Pennsylvania Freshmen | 33 | ? | |
| 1921 | W | Blair Hall (NJ) | 14 | Phillipsburg HS (NJ) | 7 | ? | |
| 1921 | L | Blair Hall (NJ) | 0 | Yale Freshmen (CT) | 33 | ? | |
| 1921 | L | Blanchester HS (OH) | 7 | Wilmington HS (OH) | 63 | ? | |
| 1921 | L | Blissfield HS (MI) | 7 | Tecumseh HS (MI) | 19 | ? | |
| 1921 | L | Bloomfield HS (IN) | 0 | Indianapolis Shortridge HS (IN) | 6 | ? | |
| 1921 | L | Bloomfield HS (KY) | 0 | Elizabethtown HS (KY) | 53 | ? | |
| 1921 | W | Bloomfield HS (NJ) | 39 | Irvington HS (NJ) | 0 | ? | |
| 1921 | L | Bloomfield HS (NJ) | 0 | Jersey City Lincoln HS (NJ) | 1 | ? | |
| 1921 | L | Bloomfield HS (NJ) | 0 | Newark Central HS (NJ) | 28 | ? | |
| 1921 | W | Bloomfield HS (NJ) | 21 | Newark East Side HS (NJ) | 0 | ? | |
| 1921 | W | Bloomfield HS (NJ) | 25 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | W | Bloomfield HS (NJ) | 20 | Orange HS (NJ) | 6 | ? | |
| 1921 | W | Bloomfield HS (NJ) | 19 | Passaic HS (NJ) | 0 | ? | |
| 1921 | L | Bloomfield HS (NJ) | 0 | Plainfield HS (NJ) | 7 | ? | |
| 1921 | W | Bloomfield HS (NJ) | 7 | Stone Hall | 0 | ? | |
| 1921 | W | Bloomfield HS (NJ) | 61 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | L | Blooming Prairie HS (MN) | 0 | Austin HS (MN) | 7 | ? | |
| 1921 | L | Bloomington HS (IL) | 0 | Peoria Central HS (IL) | 6 | ? | |
| 1921 | L | Bloomsburg (PA) | 0 | Lycoming (PA) | 28 | Bloomsburg, PA | |
| 1921 | T | Bloomsburg (PA) | 0 | Millersville (PA) | 0 | Bloomsburg, PA | |
| 1921 | L | Bloomsburg (PA) | 0 | Northumberland HS (PA) | 21 | Bloomsburg, PA | |
| 1921 | L | Bloomsburg (PA) | 0 | Shippensburg (PA) | 13 | Shippensburg, PA | |
| 1921 | L | Bloomsburg (PA) | 0 | Wyoming Seminary (PA) | 35 | Kingston, PA | |
| 1921 | L | Bloomsburg (PA) | 0 | Scranton (PA) | 6 | Scranton, PA | |
| 1921 | L | Bloomsburg (PA) | 0 | Keystone Academy (PA) | 6 | Factoryville, PA | |
| 1921 | W | Bloomsburg (PA) | 32 | Shenandoah HS (PA) | 0 | Bloomsburg, PA | |
| 1921 | L | Blue Earth HS (MN) | 0 | Mankato HS (MN) | 45 | ? | |
| 1921 | L | Blue Earth HS (MN) | 0 | Saint Peter HS (MN) | 48 | ? | |
| 1921 | L | Blue Mound HS (IL) | 0 | Lincoln HS (IL) | 1 | ? | |
| 1921 | L | Blue Ridge (MD) | 0 | Asheville HS (NC) | 7 | ? | |
| 1921 | L | Blue Ridge (MD) | 7 | Bingham Military School (NC) | 35 | ? | |
| 1921 | L | Bluefield St. (WV) | 0 | West Virginia St. | 73 | ? | |
| 1921 | L | Bluffton (OH) | 0 | Ohio Northern | 47 | Bluffton, OH | Practice Game |
| 1921 | W | Bluffton (OH) | 14 | Toledo (OH) | 0 | Bluffton, OH | |
| 1921 | L | Bluffton HS (OH) | 0 | Toledo Waite HS (OH) | 48 | ? | |
| 1921 | W | Boise HS (ID) | 5 | Twin Falls HS (ID) | 3 | ? | |
| 1921 | T | Bordentown Manual Training (NJ) | 0 | Bordentown Military Institute (NJ) | 0 | ? | |
| 1921 | W | Bordentown Manual Training (NJ) | 7 | Burlington HS (NJ) | 0 | ? | |
| 1921 | L | Bordentown Manual Training (NJ) | 0 | Lincoln (PA) | 26 | Bordentown, NJ | |
| 1921 | W | Bordentown Manual Training (NJ) | 46 | Merchantville HS (NJ) | 0 | ? | |
| 1921 | L | Bordentown Manual Training (NJ) | 0 | Moorestown Friends School (NJ) | 31 | ? | |
| 1921 | L | Bordentown Manual Training (NJ) | 0 | Moorestown HS (NJ) | 55 | ? | |
| 1921 | W | Bordentown Manual Training (NJ) | 6 | Newtown HS (PA) | 0 | ? | |
| 1921 | T | Bordentown Manual Training (NJ) | 0 | Palmyra HS (NJ) | 0 | ? | |
| 1921 | T | Bordentown Manual Training (NJ) | 0 | Princeton HS (NJ) | 0 | ? | |
| 1921 | W | Bordentown Manual Training (NJ) | 14 | Rider (NJ) | 0 | Bordentown, NJ | |
| 1921 | T | Bordentown Military Institute (NJ) | 0 | Bordentown Manual Training (NJ) | 0 | ? | |
| 1921 | L | Bordentown Military Institute (NJ) | 0 | Eastern HS | 14 | ? | |
| 1921 | L | Bordentown Military Institute (NJ) | 0 | Easton HS (PA) | 14 | ? | |
| 1921 | L | Bordentown Military Institute (NJ) | 6 | Montclair Military Academy (NJ) | 51 | ? | |
| 1921 | L | Bordentown Military Institute (NJ) | 0 | New Brunswick HS (NJ) | 19 | ? | |
| 1921 | L | Bordentown Military Institute (NJ) | 0 | Princeton Prep School (NJ) | 32 | Bordentown, NJ | |
| 1921 | L | Bordentown Military Institute (NJ) | 0 | Rutgers Prep School (NJ) | 44 | ? | |
| 1921 | L | Bordentown Military Institute (NJ) | 0 | Swarthmore Prep School (PA) | 13 | ? | |
| 1921 | L | Bordentown Military Institute (NJ) | 7 | Trenton HS (NJ) | 13 | Trenton, NJ | Chambers Street Field |
| 1921 | W | Bordentown Military Institute (NJ) | 6 | Pennington Seminary (NJ) | 0 | ? | |
| 1921 | L | Boston (MA) | 0 | Harvard (MA) | 10 | Cambridge, MA | |
| 1921 | W | Boston (MA) | 14 | Rhode Island | 0 | Boston, MA | |
| 1921 | W | Boston (MA) | 14 | Trinity (CT) | 0 | Hartford, CT | |
| 1921 | W | Boston (MA) | 7 | Wesleyan (CT) | 0 | Middletown, CT | |
| 1921 | L | Boston (MA) | 0 | Boston College (MA) | 13 | Chestnut Hill, MA | |
| 1921 | W | Boston (MA) | 8 | Tufts (MA) | 7 | Medford, MA | |
| 1921 | W | Boston (MA) | 52 | Worcester Tech (MA) | 0 | Boston, MA | |
| 1921 | W | Boston (MA) | 20 | Norwich (VT) | 14 | Boston, MA | |
| 1921 | W | Boston College (MA) | 23 | Baylor (TX) | 7 | Dallas, TX | |
| 1921 | L | Boston College (MA) | 0 | Detroit (MI) | 28 | Chestnut Hill, MA | |
| 1921 | T | Boston College (MA) | 0 | Fordham (NY) | 0 | New York, NY | |
| 1921 | L | Boston College (MA) | 10 | Georgetown (DC) | 14 | Boston, MA | |
| 1921 | L | Boston College (MA) | 0 | Holy Cross (MA) | 41 | Boston, MA | |
| 1921 | W | Boston College (MA) | 13 | Boston (MA) | 0 | Chestnut Hill, MA | |
| 1921 | W | Boston College (MA) | 14 | Marietta (OH) | 0 | Chestnut Hill, MA | |
| 1921 | W | Boston College (MA) | 25 | Providence (RI) | 0 | Chestnut Hill, MA | |
| 1921 | W | Boston Commerce HS (MA) | 10 | Boston Latin School (MA) | 6 | ? | |
| 1921 | L | Boston Commerce HS (MA) | 10 | Framingham HS (MA) | 28 | ? | |
| 1921 | L | Boston Commerce HS (MA) | 0 | Norwood HS (MA) | 14 | ? | |
| 1921 | T | Boston English HS (MA) | 0 | Boston Latin School (MA) | 0 | ? | |
| 1921 | W | Boston Hyde Park HS (MA) | 13 | Boston South HS (MA) | 0 | ? | |
| 1921 | W | Boston Hyde Park HS (MA) | 14 | Boston Trade | 7 | ? | |
| 1921 | L | Boston Hyde Park HS (MA) | 0 | Boston West Roxbury HS (MA) | 20 | ? | |
| 1921 | L | Boston Hyde Park HS (MA) | 7 | Brighton HS (MA) | 13 | ? | |
| 1921 | W | Boston Hyde Park HS (MA) | 24 | Charlestown HS (MA) | 0 | ? | |
| 1921 | L | Boston Hyde Park HS (MA) | 6 | Dedham HS (MA) | 7 | ? | |
| 1921 | W | Boston Hyde Park HS (MA) | 21 | East Boston HS (MA) | 0 | ? | |
| 1921 | L | Boston Hyde Park HS (MA) | 0 | Fitchburg HS (MA) | 35 | ? | |
| 1921 | L | Boston Hyde Park HS (MA) | 0 | Milton Academy (MA) | 18 | ? | |
| 1921 | L | Boston Latin School (MA) | 0 | Boston College HS (MA) | 3 | ? | |
| 1921 | L | Boston Latin School (MA) | 6 | Boston Commerce HS (MA) | 10 | ? | |
| 1921 | T | Boston Latin School (MA) | 0 | Boston English HS (MA) | 0 | ? | |
| 1921 | L | Boston Latin School (MA) | 0 | Brockton HS (MA) | 56 | ? | |
| 1921 | W | Boston Latin School (MA) | 13 | Dorchester HS (MA) | 0 | ? | |
| 1921 | L | Boston Latin School (MA) | 0 | Groton School (MA) | 28 | ? | |
| 1921 | W | Boston Latin School (MA) | 34 | Mechanics Arts HS | 0 | ? | |
| 1921 | W | Boston Latin School (MA) | 7 | Quincy HS (MA) | 0 | ? | |
| 1921 | L | Boston South HS (MA) | 0 | Boston Hyde Park HS (MA) | 13 | ? | |
| 1921 | L | Boston Trade | 7 | Boston Hyde Park HS (MA) | 14 | ? | |
| 1921 | W | Boston West Roxbury HS (MA) | 20 | Boston Hyde Park HS (MA) | 0 | ? | |
| 1921 | W | Boston West Roxbury HS (MA) | 13 | Brighton HS (MA) | 0 | ? | |
| 1921 | L | Boulder Prep School (CO) | 0 | Denver East HS (CO) | 18 | ? | |
| 1921 | L | Boulder Prep School (CO) | 6 | Denver South HS (CO) | 28 | ? | |
| 1921 | L | Boulder Prep School (CO) | 13 | Fort Collins HS (CO) | 14 | ? | |
| 1921 | L | Boulder Prep School (CO) | 6 | Greeley HS (CO) | 48 | ? | |
| 1921 | L | Boulder Prep School (CO) | 3 | Longmont HS (CO) | 7 | ? | |
| 1921 | L | Boulder Prep School (CO) | 0 | Loveland HS (CO) | 14 | ? | |
| 1921 | W | Boulder Prep School (CO) | 14 | Windsor HS (CO) | 0 | ? | |
| 1921 | L | Bound Brook HS (NJ) | 0 | Bernards HS (NJ) | 34 | ? | |
| 1921 | L | Bound Brook HS (NJ) | 0 | Westfield HS (NJ) | 40 | ? | |
| 1921 | W | Bowdoin (ME) | 18 | Colby (ME) | 6 | Brunswick, ME | |
| 1921 | W | Bowdoin (ME) | 7 | Trinity (CT) | 0 | Hartford, CT | |
| 1921 | W | Bowdoin (ME) | 9 | Rhode Island | 0 | Brunswick, ME | |
| 1921 | W | Bowdoin (ME) | 14 | Maine | 7 | Orono, ME | |
| 1921 | T | Bowdoin (ME) | 0 | Williams (MA) | 0 | Williamstown, MA | |
| 1921 | W | Bowdoin (ME) | 20 | Tufts (MA) | 0 | Brunswick, ME | |
| 1921 | L | Bowling Green (OH) | 0 | Ashland (OH) | 27 | Ashland, OH | |
| 1921 | W | Bowling Green (OH) | 151 | Findlay (OH) | 0 | Bowling Green, OH | |
| 1921 | W | Bowling Green (OH) | 20 | Toledo (OH) | 7 | Toledo, OH | |
| 1921 | T | Bowling Green (OH) | 0 | Kent St. (OH) | 0 | Bowling Green, OH | |
| 1921 | W | Bowling Green (OH) | 7 | Defiance (OH) | 0 | Defiance, OH | |
| 1921 | L | Bowling Green Academy (KY) | 0 | Kentucky St. | 33 | ? | |
| 1921 | L | Bowling Green HS (OH) | 0 | Fostoria HS (OH) | 49 | ? | |
| 1921 | L | Box Elder HS (MT) | 0 | Brigham Young College (UT) | 30 | ? | |
| 1921 | W | Box Elder HS (MT) | 14 | Ogden HS (UT) | 13 | ? | |
| 1921 | L | Braddock HS (PA) | 0 | Duquesne HS (PA) | 33 | ? | |
| 1921 | L | Bradley (IL) | 7 | Carthage (WI) | 14 | Peoria, IL | |
| 1921 | W | Bradley (IL) | 3 | Eureka (IL) | 0 | Eureka, IL | |
| 1921 | W | Bradley (IL) | 20 | Illinois College | 0 | Peoria, IL | |
| 1921 | W | Bradley (IL) | 14 | Illinois St. | 0 | Normal, IL | |
| 1921 | W | Bradley (IL) | 40 | Lincoln College (IL) | 0 | Lincoln, IL | |
| 1921 | W | Bradley (IL) | 41 | Northern Illinois | 0 | Peoria, IL | |
| 1921 | W | Bradley (IL) | 62 | Hedding (IL) | 0 | Peoria, IL | |
| 1921 | W | Bradley (IL) | 21 | Illinois Wesleyan | 7 | Bloomington, IL | |
| 1921 | L | Bradley (IL) | 0 | Lombard (IL) | 58 | Peoria, IL | |
| 1921 | W | Bradley (IL) | 13 | Augustana (IL) | 0 | Peoria, IL | |
| 1921 | W | Bradley County HS (TN) | 23 | Tennessee Military Institute | 7 | ? | |
| 1921 | T | Bradley JV (IL) | 0 | Western Illinois | 0 | Macomb, IL | |
| 1921 | L | Brainerd HS (MN) | 0 | Little Falls HS (MN) | 59 | ? | |
| 1921 | L | Braintree HS (MA) | 0 | Quincy HS (MA) | 43 | ? | |
| 1921 | L | Braintree HS (MA) | 0 | Thayer Academy (MA) | 35 | ? | |
| 1921 | L | Brawley HS (CA) | 8 | El Centro Central HS (CA) | 27 | ? | |
| 1921 | L | Brawley HS (CA) | 0 | El Centro Central HS (CA) | 37 | ? | |
| 1921 | W | Brazil HS (IN) | 6 | Indianapolis Shortridge HS (IN) | 0 | ? | |
| 1921 | L | Bremerton Navy (WA) | 0 | Puget Sound (WA) | 26 | Tacoma, WA | |
| 1921 | L | Brewster Academy (NH) | 0 | Manchester HS (NH) | 23 | ? | |
| 1921 | L | Brewster Academy (NH) | 0 | Tilton Seminary (NH) | 12 | ? | |
| 1921 | L | Bridgeport HS (CT) | 2 | Chicopee HS (MA) | 6 | ? | |
| 1921 | T | Bridgeport HS (CT) | 0 | Crosby HS | 0 | ? | |
| 1921 | T | Bridgeport HS (CT) | 0 | Crosby HS (CT) | 0 | ? | |
| 1921 | W | Bridgeport HS (CT) | 33 | Derby HS (CT) | 0 | ? | |
| 1921 | L | Bridgeport HS (CT) | 0 | Flushing HS (NY) | 7 | ? | |
| 1921 | W | Bridgeport HS (CT) | 18 | Harford Bulkeley HS (CT) | 6 | ? | |
| 1921 | L | Bridgeport HS (CT) | 0 | New Haven HS (CT) | 6 | ? | |
| 1921 | W | Bridgeport HS (CT) | 13 | New York HS of Commerce (NY) | 7 | ? | |
| 1921 | L | Bridgeport HS (CT) | 7 | Springfield B Team (MA) | 14 | ? | |
| 1921 | W | Bridgeport HS (CT) | 66 | Wilby HS | 0 | ? | |
| 1921 | L | Bridgeport HS (CT) | 0 | New York Freshmen (NY) | 6 | New York, NY | Ohio Field |
| 1921 | L | Bridgeport HS (WV) | 0 | Richland District HS (WV) | 13 | ? | |
| 1921 | L | Bridgeton HS (NJ) | 0 | Atlantic City HS (NJ) | 28 | ? | |
| 1921 | W | Bridgeton HS (NJ) | 6 | Millville HS (NJ) | 0 | ? | |
| 1921 | L | Bridgeton HS (NJ) | 7 | Penns Grove HS (NJ) | 13 | ? | |
| 1921 | W | Bridgeton HS (NJ) | 19 | Pleasantville HS (NJ) | 0 | ? | |
| 1921 | L | Bridgeton HS (NJ) | 0 | Wenonah Military Academy (NJ) | 20 | ? | |
| 1921 | L | Bridgeville HS (DE) | 0 | Newark HS (DE) | 26 | ? | |
| 1921 | L | Bridgewater HS (MA) | 7 | Norwood HS (MA) | 48 | ? | |
| 1921 | W | Brigham Young (UT) | 14 | Brigham Young College (UT) | 13 | ? | |
| 1921 | L | Brigham Young (UT) | 12 | Ogden AC (UT) | 17 | Ogden, UT | |
| 1921 | W | Brigham Young (UT) | 48 | Ogden AC (UT) | 7 | Provo, UT | |
| 1921 | L | Brigham Young (UT) | 0 | Utah Freshmen | 16 | Provo, UT | |
| 1921 | L | Brigham Young (UT) | 14 | Utah Freshmen | 16 | Salt Lake City, UT | Cummings Field |
| 1921 | L | Brigham Young (UT) | 0 | Utah St. Freshmen | 37 | ? | |
| 1921 | W | Brigham Young (UT) | 21 | Utah St. Freshmen | 0 | ? | |
| 1921 | W | Brigham Young College (UT) | 30 | Box Elder HS (MT) | 0 | ? | |
| 1921 | L | Brigham Young College (UT) | 13 | Brigham Young (UT) | 14 | Provo, UT | |
| 1921 | W | Brigham Young College (UT) | 34 | Idaho Falls HS (ID) | 0 | ? | |
| 1921 | L | Brigham Young College (UT) | 0 | Idaho St. | 6 | Logan, UT | |
| 1921 | T | Brigham Young College (UT) | 0 | Ricks JC (ID) | 0 | ? | |
| 1921 | T | Brigham Young College (UT) | 7 | Utah St. Freshmen | 7 | ? | |
| 1921 | W | Brigham Young College (UT) | 7 | Weber JC (UT) | 0 | ? | |
| 1921 | W | Brighton HS (MA) | 13 | Boston Hyde Park HS (MA) | 7 | ? | |
| 1921 | L | Brighton HS (MA) | 0 | Boston West Roxbury HS (MA) | 13 | ? | |
| 1921 | T | Brighton HS (MA) | 0 | Dedham HS (MA) | 0 | ? | |
| 1921 | W | Brighton HS (MA) | 14 | East Boston HS (MA) | 0 | ? | |
| 1921 | W | Brighton HS (MA) | 20 | Saugus HS (MA) | 6 | ? | |
| 1921 | L | Bristol HS (CT) | 0 | New Britain HS (CT) | 46 | ? | |
| 1921 | L | Bristol HS (PA) | 0 | Abington HS (PA) | 31 | ? | |
| 1921 | L | Bristol HS (PA) | 0 | Burlington HS (NJ) | 1 | ? | |
| 1921 | L | Bristol HS (PA) | 0 | Lambertville HS (NJ) | 6 | ? | |
| 1921 | W | Bristol HS (PA) | 49 | Longhorne | 0 | ? | |
| 1921 | W | Bristol HS (PA) | 81 | Morrisville HS (PA) | 7 | ? | |
| 1921 | L | Bristol HS (PA) | 0 | New Jersey School for the Deaf | 31 | ? | |
| 1921 | W | Bristol HS (PA) | 59 | Newtown HS (PA) | 0 | ? | |
| 1921 | L | Bristol HS (PA) | 0 | Palmyra HS (NJ) | 26 | ? | |
| 1921 | L | Bristol HS (PA) | 0 | Palmyra HS (PA) | 26 | ? | |
| 1921 | L | Bristol HS (PA) | 0 | Quakertown HS (PA) | 68 | ? | |
| 1921 | T | Bristol HS (PA) | 0 | Wilmington HS (DE) | 0 | ? | |
| 1921 | L | Bristol HS (VA) | 7 | Roanoke HS (VA) | 53 | ? | |
| 1921 | L | Bristow HS (OK) | 0 | Sapulpa HS (OK) | 14 | ? | |
| 1921 | L | Broaddus College (WV) | 0 | Davis & Elkins (WV) | 6 | ? | |
| 1921 | L | Broaddus College (WV) | 0 | Fairmont St. (WV) | 6 | Fairmont, WV | |
| 1921 | W | Broaddus College (WV) | 1 | Fairmont St. (WV) | 0 | Philippi, WV | Fairmont St. Forfeits |
| 1921 | W | Broaddus College (WV) | 42 | Glenville St. (WV) | 7 | ? | |
| 1921 | L | Broaddus College (WV) | 0 | Potomac St. (WV) | 12 | ? | |
| 1921 | L | Broaddus College (WV) | 0 | Salem College (WV) | 7 | ? | |
| 1921 | L | Broaddus College (WV) | 0 | West Virginia B Team | 28 | ? | |
| 1921 | L | Broaddus College (WV) | 3 | Marshall (WV) | 13 | ? | |
| 1921 | W | Brockton HS (MA) | 56 | Boston Latin School (MA) | 0 | ? | |
| 1921 | W | Brockton HS (MA) | 14 | Brockton HS Alumni (MA) | 12 | ? | |
| 1921 | W | Brockton HS (MA) | 19 | Deerfield Shields HS (IL) | 14 | ? | |
| 1921 | T | Brockton HS (MA) | 6 | Everett HS (MA) | 6 | ? | |
| 1921 | W | Brockton HS (MA) | 56 | Fall River Durfee HS (MA) | 0 | ? | |
| 1921 | W | Brockton HS (MA) | 56 | Fall River Durfee HS (MA) | 0 | ? | |
| 1921 | L | Brockton HS (MA) | 13 | Haverhill HS (MA) | 21 | ? | |
| 1921 | W | Brockton HS (MA) | 40 | New Bedford HS (MA) | 0 | ? | |
| 1921 | W | Brockton HS (MA) | 34 | Quincy HS (MA) | 0 | ? | |
| 1921 | T | Brockton HS (MA) | 0 | Waltham HS (MA) | 0 | ? | |
| 1921 | L | Brockton HS Alumni (MA) | 12 | Brockton HS (MA) | 14 | ? | |
| 1921 | W | Broken Arrow HS (OK) | 39 | Collinsville HS (OK) | 0 | ? | |
| 1921 | L | Broken Bow HS (NE) | 7 | Alliance HS (NE) | 12 | ? | |
| 1921 | T | Bronxville HS (NY) | 12 | Concordia Prep School JV (NY) | 12 | ? | |
| 1921 | T | Bronxville HS (NY) | 6 | Crestwood AC | 6 | ? | |
| 1921 | L | Bronxville HS (NY) | 7 | Mount Vernon HS JV (NY) | 12 | ? | |
| 1921 | W | Bronxville HS (NY) | 1 | R. Ascham | 0 | ? | |
| 1921 | W | Bronxville HS (NY) | 19 | Scarsdale HS (NY) | 7 | ? | |
| 1921 | L | Brookhaven HS (MS) | 2 | Jackson HS (MS) | 21 | ? | |
| 1921 | L | Brookings HS (SD) | 0 | Clark HS (SD) | 20 | ? | |
| 1921 | L | Brookings HS (SD) | 0 | Pipestone HS (MN) | 42 | ? | |
| 1921 | L | Brookline HS (MA) | 0 | Boston College HS (MA) | 6 | ? | |
| 1921 | W | Brookline HS (MA) | 2 | Cambridge Latin & HS (MA) | 0 | ? | |
| 1921 | L | Brookline HS (MA) | 0 | Everett HS (MA) | 7 | ? | |
| 1921 | L | Brookline HS (MA) | 7 | Haverhill HS (MA) | 21 | ? | |
| 1921 | L | Brookline HS (MA) | 0 | Malden HS (MA) | 7 | ? | |
| 1921 | L | Brookline HS (MA) | 0 | Medford HS (MA) | 7 | ? | |
| 1921 | L | Brookline HS (MA) | 0 | Newton North HS (MA) | 12 | ? | |
| 1921 | L | Brookline HS (MA) | 0 | Rindge Tech (MA) | 21 | ? | |
| 1921 | W | Brookline HS (MA) | 2 | Somerville HS (MA) | 0 | ? | |
| 1921 | W | Brookline HS (MA) | 7 | Winthrop HS (MA) | 0 | ? | |
| 1921 | W | Brooklyn Boys HS (NY) | 6 | Brooklyn Commercial HS (NY) | 0 | ? | |
| 1921 | L | Brooklyn Boys HS (NY) | 0 | Brooklyn Manual Training HS (NY) | 21 | ? | |
| 1921 | T | Brooklyn Boys HS (NY) | 7 | Brooklyn Poly Prep School (NY) | 7 | ? | |
| 1921 | T | Brooklyn Boys HS (NY) | 6 | Evander Childs HS (NY) | 6 | ? | |
| 1921 | T | Brooklyn Boys HS (NY) | 0 | New Utrecht HS (NY) | 0 | ? | |
| 1921 | L | Brooklyn Boys HS (NY) | 0 | New York Erasmus Hall HS (NY) | 6 | ? | |
| 1921 | T | Brooklyn Boys HS (NY) | 0 | New York HS of Commerce (NY) | 0 | ? | |
| 1921 | L | Brooklyn Boys HS (NY) | 6 | Rutgers Prep School (NJ) | 7 | ? | |
| 1921 | T | Brooklyn Boys HS (NY) | 0 | Saint Paul's School (NY) | 0 | ? | |
| 1921 | L | Brooklyn Commercial HS (NY) | 0 | Brooklyn Boys HS (NY) | 6 | ? | |
| 1921 | L | Brooklyn Commercial HS (NY) | 0 | Brooklyn Manual Training HS (NY) | 28 | ? | |
| 1921 | L | Brooklyn Commercial HS (NY) | 0 | Brooklyn Poly Prep School (NY) | 49 | ? | |
| 1921 | T | Brooklyn Commercial HS (NY) | 0 | Marquand School (NY) | 0 | ? | |
| 1921 | T | Brooklyn Commercial HS (NY) | 0 | New Utrecht HS (NY) | 0 | ? | |
| 1921 | L | Brooklyn Commercial HS (NY) | 0 | New York Erasmus Hall HS (NY) | 31 | ? | |
| 1921 | L | Brooklyn Commercial HS (NY) | 0 | Stuyvesant HS (NY) | 6 | ? | |
| 1921 | W | Brooklyn Evening HS (NY) | 30 | 106th Infantry | 0 | ? | |
| 1921 | L | Brooklyn Evening HS (NY) | 14 | Concordia Prep School (NY) | 37 | ? | |
| 1921 | W | Brooklyn Evening HS (NY) | 42 | Cooper Union (NY) | 0 | Brooklyn, NY | P.S.A.L. Field |
| 1921 | W | Brooklyn Evening HS (NY) | 19 | Freeport HS (NY) | 0 | ? | |
| 1921 | L | Brooklyn Evening HS (NY) | 0 | Kingston Academy (NY) | 7 | ? | |
| 1921 | W | Brooklyn Evening HS (NY) | 19 | Nyack HS (NY) | 0 | ? | |
| 1921 | W | Brooklyn Evening HS (NY) | 7 | Saint John's Prep (NY) | 0 | ? | |
| 1921 | W | Brooklyn Evening HS (NY) | 20 | West Orange HS (NJ) | 0 | ? | |
| 1921 | W | Brooklyn Evening HS (NY) | 31 | Upsala (NJ) | 14 | East Orange, NJ | |
| 1921 | W | Brooklyn Manual Training HS (NY) | 21 | Brooklyn Boys HS (NY) | 0 | ? | |
| 1921 | W | Brooklyn Manual Training HS (NY) | 28 | Brooklyn Commercial HS (NY) | 0 | ? | |
| 1921 | L | Brooklyn Manual Training HS (NY) | 7 | Brooklyn Poly Prep School (NY) | 47 | ? | |
| 1921 | L | Brooklyn Manual Training HS (NY) | 0 | Brooklyn Prep School (NY) | 6 | ? | |
| 1921 | L | Brooklyn Manual Training HS (NY) | 7 | Flushing HS (NY) | 14 | ? | |
| 1921 | L | Brooklyn Manual Training HS (NY) | 2 | Mount Vernon HS (NY) | 20 | ? | |
| 1921 | T | Brooklyn Manual Training HS (NY) | 7 | New Utrecht HS (NY) | 7 | ? | |
| 1921 | W | Brooklyn Manual Training HS (NY) | 33 | Saint Paul's School (NY) | 3 | ? | |
| 1921 | W | Brooklyn Manual Training HS (NY) | 7 | New York Erasmus Hall HS (NY) | 0 | ? | |
| 1921 | T | Brooklyn Poly Prep School (NY) | 7 | Brooklyn Boys HS (NY) | 7 | ? | |
| 1921 | W | Brooklyn Poly Prep School (NY) | 49 | Brooklyn Commercial HS (NY) | 0 | ? | |
| 1921 | W | Brooklyn Poly Prep School (NY) | 47 | Brooklyn Manual Training HS (NY) | 7 | ? | |
| 1921 | W | Brooklyn Poly Prep School (NY) | 52 | Marquand School (NY) | 0 | ? | |
| 1921 | W | Brooklyn Poly Prep School (NY) | 35 | New Utrecht HS (NY) | 0 | ? | |
| 1921 | T | Brooklyn Poly Prep School (NY) | 0 | New York Erasmus Hall HS (NY) | 0 | ? | |
| 1921 | W | Brooklyn Poly Prep School (NY) | 91 | Adelphi Academy (NY) | 0 | Brooklyn, NY | Poly Field |
| 1921 | W | Brooklyn Prep School (NY) | 6 | Brooklyn Manual Training HS (NY) | 0 | ? | |
| 1921 | W | Brooklyn Prep School (NY) | 6 | Flushing HS (NY) | 0 | ? | |
| 1921 | L | Brooklyn Prep School (NY) | 6 | Fordham Prep (NY) | 42 | ? | |
| 1921 | W | Brooklyn Prep School (NY) | 6 | Saint Joseph's Prep School (PA) | 0 | ? | |
| 1921 | W | Brooklyn Prep School (NY) | 13 | Saint Peter's Prep (NJ) | 0 | ? | |
| 1921 | L | Brothers College | 0 | Glenn County HS (CA) | 40 | ? | |
| 1921 | W | Brown (RI) | 7 | Colgate (NY) | 0 | Providence, RI | |
| 1921 | W | Brown (RI) | 6 | Rhode Island | 0 | Providence, RI | |
| 1921 | T | Brown (RI) | 0 | Springfield (MA) | 0 | Springfield, MA | |
| 1921 | L | Brown (RI) | 0 | Syracuse (NY) | 28 | Syracuse, NY | |
| 1921 | L | Brown (RI) | 7 | Yale (CT) | 45 | New Haven, CT | |
| 1921 | W | Brown (RI) | 12 | Colby (ME) | 7 | Providence, RI | |
| 1921 | W | Brown (RI) | 55 | Saint Bonaventure (NY) | 0 | Providence, RI | |
| 1921 | W | Brown (RI) | 13 | New York (NY) | 0 | Providence, RI | |
| 1921 | L | Brown (RI) | 7 | Harvard (MA) | 9 | Cambridge, MA | |
| 1921 | L | Brown Prep School (PA) | 0 | La Salle Prep School (PA) | 48 | ? | |
| 1921 | L | Brown Prep School (PA) | 0 | Saint Joseph's Prep School (PA) | 63 | ? | |
| 1921 | W | Browne & Nichols School (MA) | 14 | Concord HS (MA) | 12 | ? | |
| 1921 | L | Browne & Nichols School (MA) | 0 | Country Day School (MA) | 25 | ? | |
| 1921 | L | Browne & Nichols School (MA) | 0 | Middlesex School (MA) | 13 | ? | |
| 1921 | L | Browne & Nichols School (MA) | 0 | Milton Academy (MA) | 7 | ? | |
| 1921 | L | Browne & Nichols School (MA) | 0 | Noble & Greenough (MA) | 13 | ? | |
| 1921 | T | Browne & Nichols School (MA) | 14 | Roxbury Latin School (MA) | 14 | ? | |
| 1921 | L | Browning HS | 0 | King School (CT) | 57 | ? | |
| 1921 | L | Brownsville Haywood County HS (TN) | 7 | Memphis (TN) | 12 | Brownsville, TN | |
| 1921 | L | Brunswick | 0 | King School (CT) | 7 | ? | |
| 1921 | W | Brush HS (CO) | 21 | Sterling HS (CO) | 6 | ? | |
| 1921 | L | Brush HS (CO) | 0 | Yuma County HS (CO) | 24 | ? | |
| 1921 | L | Brush HS (CO) | 0 | Yuma County HS (CO) | 56 | ? | |
| 1921 | L | Bryan HS (OH) | 0 | Fostoria HS (OH) | 20 | ? | |
| 1921 | T | Bryn Athyn Academy (PA) | 7 | Frankford HS (PA) | 7 | ? | |
| 1921 | W | Bryn Athyn Academy (PA) | 21 | Pennsylvania Institution for the Deaf | 7 | ? | |
| 1921 | T | Bryn Athyn Academy (PA) | 0 | Philadelphia Central HS (PA) | 0 | ? | |
| 1921 | L | Bryn Athyn Academy (PA) | 0 | Swarthmore Prep School (PA) | 14 | ? | |
| 1921 | T | Bryn Athyn HS (PA) | 7 | Philadelphia West Catholic HS (PA) | 7 | ? | |
| 1921 | W | Bryn Athyn HS (PA) | 16 | Philadelphia West HS (PA) | 12 | ? | |
| 1921 | W | Bryn Athyn HS (PA) | 7 | Radnor HS (PA) | 0 | ? | |
| 1921 | W | Bryn Athyn HS (PA) | 19 | Wenonah Military Academy (NJ) | 7 | ? | |
| 1921 | L | Bryson (TN) | 0 | Alabama | 95 | Tuscaloosa, AL | |
| 1921 | L | Bryson (TN) | 0 | Bethel (KY) | 16 | ? | |
| 1921 | L | Bryson (TN) | 0 | Cumberland (TN) | 14 | ? | |
| 1921 | L | Bryson (TN) | 0 | Morgan Prep School (TN) | 54 | Fayetteville, TN | |
| 1921 | W | Bryson (TN) | 7 | Rhodes (TN) | 0 | ? | |
| 1921 | W | Bryson (TN) | 28 | Saint Bernard JC (AL) | 13 | Fayetteville, TN | |
| 1921 | L | Bryson (TN) | 0 | Tennessee-Chattanooga | 53 | Chattanooga, TN | |
| 1921 | L | Bryson (TN) | 0 | Sewanee (TN) | 102 | Sewanee, TN | |
| 1921 | T | Buckhannon HS (WV) | 6 | Charleston HS (WV) | 6 | ? | |
| 1921 | W | Buckhannon HS (WV) | 13 | Clarksburg HS (WV) | 7 | ? | |
| 1921 | W | Buckhannon HS (WV) | 34 | Clarksburg Victory HS (WV) | 0 | ? | |
| 1921 | W | Buckhannon HS (WV) | 27 | Fairmont HS (WV) | 0 | ? | |
| 1921 | W | Buckhannon HS (WV) | 35 | Morgantown HS (WV) | 0 | ? | |
| 1921 | W | Buckhannon HS (WV) | 34 | Pennsboro HS (WV) | 0 | ? | |
| 1921 | W | Buckhannon HS (WV) | 13 | Washington Irving HS (WV) | 7 | ? | |
| 1921 | W | Buckhannon HS (WV) | 24 | Weston HS (WV) | 7 | ? | |
| 1921 | W | Bucknell (PA) | 41 | Catholic (DC) | 0 | Lewisburg, PA | |
| 1921 | W | Bucknell (PA) | 21 | Dickinson (PA) | 0 | Carlisle, PA | |
| 1921 | L | Bucknell (PA) | 7 | Lafayette (PA) | 20 | Lewisburg, PA | |
| 1921 | W | Bucknell (PA) | 62 | Susquehanna (PA) | 0 | Lewisburg, PA | |
| 1921 | T | Bucknell (PA) | 0 | West Virginia | 0 | Morgantown, WV | |
| 1921 | L | Bucknell (PA) | 0 | Washington & Jefferson (PA) | 26 | Washington, PA | |
| 1921 | L | Bucknell (PA) | 0 | Navy (MD) | 6 | Annapolis, MD | |
| 1921 | W | Bucknell (PA) | 14 | Muhlenberg (PA) | 0 | Allentown, PA | |
| 1921 | W | Bucknell (PA) | 34 | Gettysburg (PA) | 7 | Harrisburg, PA | |
| 1921 | T | Bucknell B Team (PA) | 0 | Bellefonte Academy (PA) | 0 | ? | |
| 1921 | L | Bucknell B Team (PA) | 7 | Mansfield (PA) | 20 | ? | |
| 1921 | L | Bucyrus HS (OH) | 0 | Sandusky HS (OH) | 28 | ? | |
| 1921 | W | Buena Vista (IA) | 14 | Ellsworth CC (IA) | 0 | Storm Lake, IA | |
| 1921 | L | Buena Vista (IA) | 0 | Morningside (IA) | 9 | ? | Game in question |
| 1921 | T | Buena Vista (IA) | 0 | Still College (IA) | 0 | Des Moines, IA | |
| 1921 | W | Buena Vista (IA) | 7 | Trinity (IA) | 0 | Storm Lake, IA | |
| 1921 | L | Buena Vista (IA) | 7 | Westmar (IA) | 10 | LeMars, IA | |
| 1921 | W | Buena Vista (IA) | 9 | Trinity (IA) | 0 | Sioux City, IA | |
| 1921 | L | Buena Vista (IA) | 20 | Dakota Wesleyan (SD) | 32 | Mitchell, SD | |
| 1921 | L | Buena Vista (IA) | 0 | Northern Iowa | 18 | Storm Lake, IA | |
| 1921 | L | Buena Vista (IA) | 7 | Columbus (SD) | 21 | Storm Lake, IA | |
| 1921 | W | Buffalo (NY) | 7 | Alfred (NY) | 0 | Buffalo, NY | |
| 1921 | L | Buffalo (NY) | 0 | Bethany (WV) | 42 | Bethany, WV | |
| 1921 | T | Buffalo (NY) | 0 | Rensselaer Tech (NY) | 0 | Buffalo, NY | |
| 1921 | W | Buffalo (NY) | 54 | Saint Stephen's College (NY) | 0 | Buffalo, NY | |
| 1921 | L | Buffalo (NY) | 13 | Allegheny (PA) | 26 | Erie, PA | |
| 1921 | T | Buffalo (NY) | 0 | Thiel (PA) | 0 | Buffalo, NY | |
| 1921 | L | Buffalo (NY) | 0 | Hobart (NY) | 37 | Geneva, NY | |
| 1921 | L | Buffalo Canisius HS (NY) | 0 | Buffalo Masten Park HS (NY) | 32 | ? | |
| 1921 | L | Buffalo HS (WY) | 0 | Sheridan HS (WY) | 58 | ? | |
| 1921 | T | Buffalo Lafayette HS (NY) | 0 | Buffalo Masten Park HS (NY) | 0 | ? | |
| 1921 | L | Buffalo Lafayette HS (NY) | 0 | Buffalo Technical HS (NY) | 6 | ? | |
| 1921 | L | Buffalo Lafayette HS (NY) | 0 | Tonawanda HS (NY) | 7 | ? | |
| 1921 | W | Buffalo Masten Park HS (NY) | 32 | Buffalo Canisius HS (NY) | 0 | ? | |
| 1921 | T | Buffalo Masten Park HS (NY) | 0 | Buffalo Lafayette HS (NY) | 0 | ? | |
| 1921 | W | Buffalo Masten Park HS (NY) | 21 | Buffalo Masten Park HS Alumni (NY) | 0 | ? | |
| 1921 | W | Buffalo Masten Park HS (NY) | 21 | Buffalo South Park HS (NY) | 3 | ? | |
| 1921 | W | Buffalo Masten Park HS (NY) | 27 | Buffalo Technical HS (NY) | 0 | ? | |
| 1921 | W | Buffalo Masten Park HS (NY) | 27 | Erie Central HS (PA) | 14 | ? | |
| 1921 | W | Buffalo Masten Park HS (NY) | 14 | Hutchinson Central HS (NY) | 0 | ? | |
| 1921 | T | Buffalo Masten Park HS (NY) | 0 | Saint John's Academy | 0 | ? | |
| 1921 | T | Buffalo Masten Park HS (NY) | 0 | Saint John's Military Academy (NY) | 0 | Manlius, NY | |
| 1921 | L | Buffalo Masten Park HS Alumni (NY) | 0 | Buffalo Masten Park HS (NY) | 21 | ? | |
| 1921 | L | Buffalo South Park HS (NY) | 3 | Buffalo Masten Park HS (NY) | 21 | ? | |
| 1921 | L | Buffalo South Park HS (NY) | 0 | Tonawanda HS (NY) | 14 | ? | |
| 1921 | W | Buffalo Technical HS (NY) | 6 | Buffalo Lafayette HS (NY) | 0 | ? | |
| 1921 | L | Buffalo Technical HS (NY) | 0 | Buffalo Masten Park HS (NY) | 27 | ? | |
| 1921 | W | Buffalo Technical HS (NY) | 18 | Canisius Prep | 0 | ? | |
| 1921 | L | Buffalo Technical HS (NY) | 0 | Elmira HS (NY) | 7 | ? | |
| 1921 | W | Buffalo Technical HS (NY) | 34 | Hutchinson Central HS (NY) | 0 | ? | |
| 1921 | W | Buffalo Technical HS (NY) | 21 | Nichols Prep School (NY) | 14 | ? | |
| 1921 | L | Buffalo Technical HS (NY) | 6 | North Tonawanda HS (NY) | 20 | ? | |
| 1921 | L | Burbank HS (CA) | 0 | South Pasadena HS (CA) | 28 | ? | |
| 1921 | L | Burke HS (SD) | 0 | Dallas HS (SD) | 44 | ? | |
| 1921 | W | Burleson College (TX) | 13 | Meridian College (TX) | 0 | Greenville, TX | |
| 1921 | L | Burleson College (TX) | 12 | North Texas | 61 | ? | |
| 1921 | L | Burleson College (TX) | 20 | Texas-Arlington | 21 | Arlington, TX | |
| 1921 | L | Burleson College (TX) | 0 | Wesley College (TX) | 28 | ? | |
| 1921 | L | Burleson College (TX) | 0 | Southeastern Oklahoma St. | 9 | Durant, OK | |
| 1921 | L | Burleson College (TX) | 0 | Texas Military College | 7 | Greenville, TX | |
| 1921 | W | Burleson College (TX) | 2 | Texas A&M-Commerce | 0 | Greenville, TX | |
| 1921 | W | Burley HS (ID) | 55 | Filer HS (ID) | 7 | ? | |
| 1921 | L | Burlington HS (NJ) | 0 | Bordentown Manual Training (NJ) | 7 | ? | |
| 1921 | W | Burlington HS (NJ) | 1 | Bristol HS (PA) | 0 | ? | |
| 1921 | T | Burlington HS (NJ) | 0 | Haddon Heights HS (NJ) | 0 | ? | |
| 1921 | W | Burlington HS (NJ) | 13 | Moorestown Friends School (NJ) | 7 | ? | |
| 1921 | L | Burlington HS (NJ) | 0 | Moorestown HS (NJ) | 21 | ? | |
| 1921 | L | Burlington HS (NJ) | 0 | Mount Holly HS (NJ) | 14 | ? | |
| 1921 | W | Burlington HS (NJ) | 58 | Newtown HS (PA) | 0 | ? | |
| 1921 | T | Burlington HS (NJ) | 7 | Palmyra HS (NJ) | 7 | ? | |
| 1921 | L | Burlington HS (NJ) | 7 | Palmyra HS (NJ) | 13 | ? | |
| 1921 | L | Burlington HS (NJ) | 7 | Palmyra HS (NJ) | 27 | ? | |
| 1921 | T | Burlington HS (NJ) | 7 | Palmyra HS (PA) | 7 | ? | |
| 1921 | L | Burlington HS (NJ) | 7 | Palmyra HS (PA) | 13 | ? | |
| 1921 | L | Burlington HS (NJ) | 7 | Palmyra HS (PA) | 27 | ? | |
| 1921 | T | Burlington HS (NJ) | 0 | Rider (NJ) | 0 | ? | |
| 1921 | W | Butler (IN) | 33 | Earlham (IN) | 7 | Indianapolis, IN | |
| 1921 | W | Butler (IN) | 28 | Franklin (IN) | 0 | Indianapolis, IN | |
| 1921 | W | Butler (IN) | 122 | Hanover (IN) | 0 | Indianapolis, IN | |
| 1921 | L | Butler (IN) | 0 | Wabash (IN) | 14 | Indianapolis, IN | |
| 1921 | W | Butler (IN) | 19 | Denison (OH) | 6 | Granville, OH | Deed's Field |
| 1921 | L | Butler (IN) | 7 | Chicago YMCA College (IL) | 14 | Indianapolis, IN | |
| 1921 | W | Butler (IN) | 70 | Rose-Hulman Tech (IN) | 6 | Indianapolis, IN | |
| 1921 | W | Butler (IN) | 3 | Michigan St. | 2 | Indianapolis, IN | |
| 1921 | L | Butler HS (NJ) | 0 | Clifton HS (NJ) | 46 | ? | |
| 1921 | L | Butler HS (NJ) | 0 | Newton HS (NJ) | 35 | ? | |
| 1921 | L | Butler HS (PA) | 0 | New Castle HS (PA) | 7 | ? | |
| 1921 | L | Butler HS (PA) | 0 | Wilkinsburg HS (PA) | 14 | ? | |
| 1921 | L | C.M. & N.A. | 6 | Asheville HS (NC) | 34 | ? | |
| 1921 | L | C.M.N.A. | 7 | Bingham Military School (NC) | 13 | ? | |
| 1921 | L | Cairo HS (IL) | 13 | Murphysboro HS (IL) | 28 | ? | |
| 1921 | L | Cairo HS (WV) | 0 | West Union HS (WV) | 21 | ? | |
| 1921 | L | Cairo HS (WV) | 0 | West Union HS (WV) | 44 | ? | |
| 1921 | W | Cal Poly-San Luis Obispo | 31 | Atascadero HS (CA) | 0 | San Luis Obispo, CA | |
| 1921 | W | Cal Poly-San Luis Obispo | 14 | Santa Maria HS (CA) | 7 | San Luis Obispo, CA | |
| 1921 | L | Cal Poly-San Luis Obispo | 7 | Taft HS (CA) | 27 | Taft, CA | |
| 1921 | W | Cal Poly-San Luis Obispo | 42 | Santa Barbara City JC (CA) | 0 | San Luis Obispo, CA | |
| 1921 | T | Cal Poly-San Luis Obispo | 7 | Santa Maria HS (CA) | 7 | San Luis Obispo, CA | |
| 1921 | L | Cal Poly-San Luis Obispo | 6 | Paso Robles HS (CA) | 7 | San Luis Obispo, CA | |
| 1921 | W | Cal St.-Chico | 21 | Chico HS (CA) | 7 | ? | |
| 1921 | W | Cal St.-Chico | 46 | Marysville HS (CA) | 0 | ? | |
| 1921 | L | Cal St.-Chico | 0 | Pacific (CA) | 28 | Stockton, CA | |
| 1921 | W | Cal St.-Chico | 14 | Sacramento HS (CA) | 7 | ? | |
| 1921 | T | Cal St.-Chico | 0 | Saint Mary's Freshmen (CA) | 0 | ? | |
| 1921 | L | Cal St.-Chico | 0 | Willows HS (CA) | 21 | ? | |
| 1921 | W | Cal St.-Chico | 3 | Fresno St. (CA) | 0 | Fresno, CA | |
| 1921 | L | Calexico HS (CA) | 0 | El Centro Central HS (CA) | 53 | ? | |
| 1921 | L | Calexico HS (CA) | 0 | El Centro Central HS (CA) | 35 | ? | |
| 1921 | L | Calgary Bronks (AB) | 0 | Alberta (AB) | 15 | Edmonton, AB (Canada) | |
| 1921 | W | Calgary Bronks (AB) | 38 | Alberta (AB) | 17 | Calgary, AB (Canada) | |
| 1921 | L | Calhoun City HS (MS) | 0 | Grenada HS (MS) | 21 | ? | |
| 1921 | W | California | 39 | Oregon | 0 | Berkeley, CA | |
| 1921 | W | California | 21 | Pacific Fleet (CA) | 10 | Berkeley, CA | |
| 1921 | W | California | 21 | Saint Mary's (CA) | 0 | Berkeley, CA | |
| 1921 | W | California | 42 | Stanford (CA) | 7 | Stanford, CA | |
| 1921 | W | California | 14 | Washington St. | 0 | Portland, OR | |
| 1921 | W | California | 28 | Ohio St. | 0 | Pasadena, CA | Tournament of Roses Game |
| 1921 | W | California | 14 | San Francisco Olympic Club (CA) | 0 | Berkeley, CA | |
| 1921 | W | California | 38 | Southern California | 7 | Berkeley, CA | |
| 1921 | W | California | 51 | Nevada | 6 | Berkeley, CA | |
| 1921 | W | California | 72 | Washington | 3 | Berkeley, CA | |
| 1921 | W | California (PA) | 14 | Indiana (PA) | 0 | ? | |
| 1921 | L | California (PA) | 0 | Slippery Rock (PA) | 49 | ? | |
| 1921 | L | California (PA) | 0 | Waynesburg (PA) | 21 | ? | |
| 1921 | L | California (PA) | 0 | Waynesburg (PA) | 13 | ? | |
| 1921 | L | California (PA) | 13 | Clarion (PA) | 14 | Clarion, PA | |
| 1921 | W | California B | 35 | California-Davis | 7 | ? | |
| 1921 | W | California Freshmen | 14 | Berkeley HS (CA) | 7 | ? | |
| 1921 | W | California Freshmen | 20 | California-Davis | 0 | Berkeley, CA | |
| 1921 | L | California Freshmen | 0 | Kern County HS (CA) | 63 | ? | |
| 1921 | W | California Freshmen | 42 | Pacific (CA) | 0 | ? | |
| 1921 | W | California Freshmen | 97 | San Francisco HS of Commerce (CA) | 0 | ? | |
| 1921 | T | California Freshmen | 0 | Sherman Indian School (CA) | 0 | ? | |
| 1921 | L | California Institute for the Deaf | 0 | Mount Diablo HS (CA) | 28 | ? | |
| 1921 | L | California Tech | 0 | Pomona-Pitzer (CA) | 10 | Pasadena, CA | |
| 1921 | L | California Tech | 6 | Redlands (CA) | 30 | Pasadena, CA | |
| 1921 | W | California Tech | 14 | USS New York | 6 | ? | |
| 1921 | L | California Tech | 0 | Whittier (CA) | 39 | Whittier, CA | |
| 1921 | L | California Tech | 3 | Occidental (CA) | 14 | Los Angeles, CA | |
| 1921 | L | California Tech | 0 | Southern California | 70 | Los Angeles, CA | |
| 1921 | W | California Tech | 27 | UCLA | 0 | Pasadena, CA | |
| 1921 | L | California Tech B Team | 0 | Fresno St. (CA) | 12 | Fresno, CA | |
| 1921 | W | California-Davis | 38 | Agnetian AC (CA) | 0 | ? | |
| 1921 | L | California-Davis | 7 | California B Team | 35 | ? | |
| 1921 | L | California-Davis | 0 | California Freshmen | 20 | Berkeley, CA | |
| 1921 | W | California-Davis | 7 | Mare Island Marines (CA) | 0 | ? | |
| 1921 | L | California-Davis | 13 | Nevada | 21 | Reno, NV | |
| 1921 | W | California-Davis | 13 | Preston Industrial School (CA) | 7 | ? | |
| 1921 | L | California-Davis | 0 | Santa Clara (CA) | 49 | Santa Clara, CA | |
| 1921 | L | California-Santa Barbara | 0 | Loyola Marymount (CA) | 68 | Santa Barbara, CA | |
| 1921 | L | California-Santa Barbara | 0 | Santa Barbara HS (CA) | 14 | ? | |
| 1921 | L | Calistoga HS (CA) | 0 | Santa Rosa HS (CA) | 1 | ? | Calistoga HS Forfeits |
| 1921 | W | Calumet HS (MI) | 7 | Hancock HS (MI) | 0 | ? | |
| 1921 | W | Calumet HS (MI) | 41 | Hancock HS (MI) | 0 | ? | |
| 1921 | W | Calumet HS (MI) | 37 | Houghton HS (MI) | 0 | ? | |
| 1921 | W | Calumet HS (MI) | 25 | Houghton HS (MI) | 0 | ? | |
| 1921 | W | Calumet HS (MI) | 19 | Ironwood HS (MI) | 13 | ? | |
| 1921 | W | Calumet HS (MI) | 46 | Lake Linden HS (MI) | 6 | ? | |
| 1921 | W | Calumet HS (MI) | 48 | Lake Linden HS (MI) | 0 | ? | |
| 1921 | L | Calumet HS (MI) | 7 | Saginaw East HS (MI) | 44 | ? | |
| 1921 | W | Calumus Club | 21 | Texas-El Paso | 0 | El Paso, TX | |
| 1921 | L | Calvert Hall | 0 | Mount Saint Joseph's College (MD) | 41 | ? | |
| 1921 | T | Calvert Hall | 0 | Rock Hill College (MD) | 0 | ? | |
| 1921 | L | Calvert Hall | 0 | Severn School (MD) | 20 | ? | |
| 1921 | L | Cambridge HS (MN) | 0 | Anoka HS (MN) | 7 | ? | |
| 1921 | W | Cambridge HS (NE) | 41 | Clay Center HS (NE) | 0 | ? | |
| 1921 | W | Cambridge HS (NE) | 47 | Fairfield HS (NE) | 0 | ? | |
| 1921 | W | Cambridge HS (NE) | 27 | Gothenburg HS (NE) | 7 | ? | |
| 1921 | W | Cambridge HS (NE) | 57 | Kearney Military Academy (NE) | 0 | ? | |
| 1921 | L | Cambridge HS (NE) | 0 | Lincoln HS (NE) | 6 | ? | |
| 1921 | W | Cambridge HS (NE) | 26 | McCook HS (NE) | 14 | ? | |
| 1921 | W | Cambridge HS (NE) | 34 | Nebraska School of Agriculture | 0 | ? | |
| 1921 | T | Cambridge HS (NE) | 7 | Oberlin HS (KS) | 7 | ? | |
| 1921 | L | Cambridge HS (NY) | 0 | Saratoga Springs HS (NY) | 38 | ? | |
| 1921 | L | Cambridge HS (OH) | 7 | Fostoria HS (OH) | 14 | ? | |
| 1921 | L | Cambridge HS (OH) | 2 | Martins Ferry HS (OH) | 7 | ? | |
| 1921 | L | Cambridge HS (OH) | 0 | Milaca HS (MN) | 48 | ? | |
| 1921 | L | Cambridge Latin & HS (MA) | 0 | Brookline HS (MA) | 2 | ? | |
| 1921 | T | Cambridge Latin & HS (MA) | 0 | Everett HS (MA) | 0 | ? | |
| 1921 | L | Cambridge Latin & HS (MA) | 6 | Malden HS (MA) | 14 | ? | |
| 1921 | W | Cambridge Latin & HS (MA) | 21 | Medford HS (MA) | 0 | ? | |
| 1921 | L | Cambridge Latin & HS (MA) | 0 | Newton North HS (MA) | 14 | ? | |
| 1921 | W | Cambridge Latin & HS (MA) | 3 | Rindge Tech (MA) | 0 | ? | |
| 1921 | W | Cambridge Latin & HS (MA) | 20 | Saint Marks School (MA) | 0 | ? | |
| 1921 | W | Cambridge Latin & HS (MA) | 14 | Somerville HS (MA) | 0 | ? | |
| 1921 | W | Cambridge Latin & HS (MA) | 14 | Dean Academy JV (MA) | 0 | Franklin, MA | |
| 1921 | L | Camden HS (AL) | 0 | Jackson Agricultural School (AL) | 102 | ? | |
| 1921 | L | Camden HS (AR) | 0 | Little Rock HS (AR) | 75 | ? | |
| 1921 | L | Camden HS (AR) | 0 | Southern Arkansas | 6 | Magnolia, AR | |
| 1921 | W | Camden HS (NJ) | 20 | Atlantic City HS (NJ) | 0 | ? | |
| 1921 | W | Camden HS (NJ) | 21 | Cheltenham HS (PA) | 0 | ? | |
| 1921 | L | Camden HS (NJ) | 7 | Coatesville HS (PA) | 48 | ? | |
| 1921 | L | Camden HS (NJ) | 0 | Germantown HS (PA) | 6 | ? | |
| 1921 | W | Camden HS (NJ) | 7 | Philadelphia Northeast HS (PA) | 6 | ? | |
| 1921 | L | Camden HS (NJ) | 7 | Trenton HS (NJ) | 11 | ? | |
| 1921 | L | Camden HS (SC) | 0 | Charleston HS (SC) | 27 | ? | |
| 1921 | W | Cameron HS (WV) | 20 | Flushing HS (OH) | 14 | ? | |
| 1921 | L | Cameron HS (WV) | 0 | Grafton HS (WV) | 28 | ? | |
| 1921 | L | Cameron HS (WV) | 0 | Linsly Military Institute (WV) | 56 | ? | |
| 1921 | L | Cameron HS (WV) | 0 | Moundsville HS (WV) | 20 | ? | |
| 1921 | L | Cameron HS (WV) | 0 | Triadelphia HS (WV) | 6 | ? | |
| 1921 | L | Cameron HS (WV) | 0 | Washington Irving HS (WV) | 44 | ? | |
| 1921 | L | Cameron HS (WV) | 0 | Waynesburg HS (PA) | 7 | ? | |
| 1921 | T | Cameron HS (WV) | 0 | Wellsburg HS (WV) | 0 | ? | |
| 1921 | L | Cameron HS (WV) | 6 | Wheeling HS (WV) | 41 | ? | |
| 1921 | L | Camp Point HS (IL) | 0 | Quincy HS (IL) | 21 | ? | |
| 1921 | L | Campion College (WI) | 4 | Loras (IA) | 6 | Dubuque, IA | |
| 1921 | W | Campion College (WI) | 6 | Luther (IA) | 3 | Decorah, IA | |
| 1921 | L | Campion College (WI) | 0 | Marquette (WI) | 55 | Milwaukee, WI | |
| 1921 | L | Campion College (WI) | 0 | Saint Ambrose (IA) | 14 | Prairie du Chien, WI | |
| 1921 | L | Campion College (WI) | 6 | Wisconsin-Platteville | 16 | Prairie du Chien, WI | |
| 1921 | W | Campion College (WI) | 13 | Wisconsin Tech | 0 | ? | |
| 1921 | L | Campion College (WI) | 0 | Marquette Academy (WI) | 42 | Praire Du Chien, WI | |
| 1921 | L | Canajoharie HS (NY) | 6 | Gloversville HS (NY) | 19 | ? | |
| 1921 | L | Caney HS (KS) | 0 | Independence HS (KS) | 26 | ? | |
| 1921 | W | Canisius (NY) | 14 | Duquesne (PA) | 0 | Buffalo, NY | |
| 1921 | L | Canisius (NY) | 0 | Niagara (NY) | 21 | Buffalo, NY | |
| 1921 | W | Canisius (NY) | 30 | Rochester Tech (NY) | 0 | Buffalo, NY | |
| 1921 | L | Canisius (NY) | 0 | Saint Bonaventure (NY) | 3 | Saint Bonaventure, NY | |
| 1921 | T | Canisius (NY) | 0 | Saint Bonaventure (NY) | 0 | Saint Bonaventure, NY | |
| 1921 | T | Canisius (NY) | 0 | Villanova (PA) | 0 | Buffalo, NY | |
| 1921 | W | Canisius (NY) | 28 | Rochester Optometry (NY) | 0 | Buffalo, NY | |
| 1921 | L | Canisius (NY) | 0 | Holy Cross (MA) | 44 | Worcester, MA | |
| 1921 | W | Canisius (NY) | 24 | John Carroll (OH) | 6 | Cleveland, OH | |
| 1921 | L | Canisius Prep | 0 | Buffalo Technical HS (NY) | 18 | ? | |
| 1921 | W | Canon City HS (CO) | 44 | Denver Manual HS (CO) | 0 | ? | |
| 1921 | W | Canon City HS (CO) | 96 | Denver North HS (CO) | 0 | ? | |
| 1921 | W | Canon City HS (CO) | 56 | Englewood HS (CO) | 0 | ? | |
| 1921 | L | Canon City HS (CO) | 7 | Florence HS (CO) | 14 | ? | |
| 1921 | W | Canon City HS (CO) | 26 | Florence HS (CO) | 0 | ? | |
| 1921 | W | Canon City HS (CO) | 42 | Pueblo Central HS (CO) | 0 | ? | |
| 1921 | W | Canon City HS (CO) | 34 | Trinidad HS (CO) | 0 | ? | |
| 1921 | L | Canonsburg HS (PA) | 0 | Washington HS (PA) | 72 | ? | |
| 1921 | W | Canton HS (IL) | 6 | Kewanee HS (IL) | 0 | ? | |
| 1921 | L | Canton HS (IL) | 6 | Pittsfield HS (IL) | 33 | ? | |
| 1921 | L | Canton HS (MS) | 0 | Jackson HS (MS) | 14 | ? | |
| 1921 | L | Canton HS (NY) | 6 | Massena HS (NY) | 34 | ? | |
| 1921 | L | Canton HS (SD) | 0 | Augustana (SD) | 13 | ? | |
| 1921 | L | Canton HS (SD) | 13 | Augustana (SD) | 14 | ? | |
| 1921 | L | Canton McKinley HS (OH) | 10 | Akron Central HS (OH) | 13 | ? | |
| 1921 | T | Canton McKinley HS (OH) | 0 | Akron South HS (OH) | 0 | ? | |
| 1921 | W | Canton McKinley HS (OH) | 14 | Kenmore HS | 6 | ? | |
| 1921 | L | Canton McKinley HS (OH) | 12 | Massillon HS (OH) | 13 | ? | |
| 1921 | L | Canton McKinley HS (OH) | 7 | Mount Union (OH) | 35 | Alliance, OH | |
| 1921 | W | Canton McKinley HS (OH) | 48 | Mount Vernon HS (OH) | 6 | ? | |
| 1921 | L | Canton McKinley HS (OH) | 7 | Youngstown Rayen HS (OH) | 10 | ? | |
| 1921 | T | Canton McKinley HS (OH) | 14 | Youngstown South HS (OH) | 14 | ? | |
| 1921 | L | Cape May C.H. (NJ) | 0 | Wildwood HS (NJ) | 13 | ? | |
| 1921 | W | Cape May C.H. (NJ) | 14 | Wildwood HS (NJ) | 7 | ? | |
| 1921 | L | Carbondale HS (IL) | 7 | Murphysboro HS (IL) | 124 | ? | |
| 1921 | L | Carbondale HS (IL) | 3 | Murphysboro HS (IL) | 68 | ? | |
| 1921 | L | Carey HS (OH) | 7 | Mount Blanchard HS (OH) | 10 | ? | |
| 1921 | L | Carey HS (OH) | 6 | Mount Blanchard HS (OH) | 7 | ? | |
| 1921 | L | Carl Junction HS (MO) | 0 | Joplin HS (MO) | 20 | ? | |
| 1921 | W | Carleton (MN) | 42 | Beloit (WI) | 0 | Northfield, MN | |
| 1921 | W | Carleton (MN) | 13 | Knox (IL) | 7 | Galesburg, IL | |
| 1921 | W | Carleton (MN) | 14 | Saint Thomas (MN) | 7 | ? | |
| 1921 | W | Carleton (MN) | 74 | Concordia-Moorhead (MN) | 0 | Moorhead, MN | |
| 1921 | W | Carleton (MN) | 20 | Saint Olaf (MN) | 3 | ? | 20-2? |
| 1921 | W | Carleton (MN) | 63 | Wisconsin-River Falls | 0 | Northfield, MN | |
| 1921 | L | Carleton (MN) | 3 | Hamline (MN) | 21 | Northfield, MN | |
| 1921 | L | Carlisle Fitting School (SC) | 7 | Porter Military Academy (SC) | 35 | ? | |
| 1921 | W | Carlstrom Field (FL) | 19 | Florida | 0 | Gainesville, FL | |
| 1921 | W | Carlton Academy (NJ) | 19 | Jersey City Kingsley HS (NJ) | 6 | ? | |
| 1921 | L | Carlton Academy (NJ) | 0 | Montclair Military Academy (NJ) | 27 | ? | |
| 1921 | W | Carlton Academy (NJ) | 28 | Morristown HS (NJ) | 0 | ? | |
| 1921 | L | Carlton Academy (NJ) | 0 | Saint Peter's Prep (NJ) | 27 | ? | |
| 1921 | L | Carlton Academy (NJ) | 0 | Seton Hall Prep School (NJ) | 24 | ? | |
| 1921 | L | Carlton Academy (NJ) | 0 | Upsala (NJ) | 32 | ? | |
| 1921 | W | Carnegie Mellon (PA) | 56 | Allegheny (PA) | 0 | Pittsburgh, PA | |
| 1921 | W | Carnegie Mellon (PA) | 21 | Maryland | 0 | Pittsburgh, PA | |
| 1921 | W | Carnegie Mellon (PA) | 42 | Saint Bonaventure (NY) | 0 | Pittsburgh, PA | |
| 1921 | W | Carnegie Mellon (PA) | 42 | Thiel (PA) | 0 | Pittsburgh, PA | |
| 1921 | L | Carnegie Mellon (PA) | 0 | Washington & Jefferson (PA) | 14 | Washington, PA | |
| 1921 | W | Carnegie Mellon (PA) | 7 | Geneva (PA) | 0 | Pittsburgh, PA | |
| 1921 | L | Carnegie Mellon (PA) | 7 | Penn St. | 28 | State College, PA | |
| 1921 | W | Carnegie Mellon (PA) | 42 | Westminster (PA) | 0 | Pittsburgh, PA | |
| 1921 | W | Carnegie Mellon (PA) | 21 | Bethany (WV) | 12 | Pittsburgh, PA | Plaid Field |
| 1921 | L | Carnegie Mellon Freshmen (PA) | 6 | Slippery Rock (PA) | 13 | ? | |
| 1921 | T | Carnegie Mellon JV (PA) | 0 | Bellefonte Academy (PA) | 0 | ? | |
| 1921 | L | Carnegie Mellon JV (PA) | 7 | Rochester HS (PA) | 13 | ? | |
| 1921 | L | Carnegie Mellon JV (PA) | 0 | Waynesburg (PA) | 13 | ? | |
| 1921 | W | Carroll (MT) | 12 | Billings Poly (MT) | 0 | Billings, MT | |
| 1921 | W | Carroll (MT) | 13 | Billings Poly (MT) | 0 | Helena, MT | |
| 1921 | L | Carroll (MT) | 0 | Montana Wesleyan | 20 | Helena, MT | |
| 1921 | L | Carroll (MT) | 0 | Montana Tech | 26 | Butte, MT | |
| 1921 | L | Carroll (MT) | 7 | Montana St. | 21 | Bozeman, MT | |
| 1921 | L | Carroll (MT) | 6 | Montana Wesleyan | 28 | Helena, MT | |
| 1921 | L | Carroll (WI) | 0 | Lawrence (WI) | 6 | Waukesha, WI | |
| 1921 | W | Carroll (WI) | 7 | Northwestern (WI) | 0 | Waukesha, WI | |
| 1921 | L | Carroll (WI) | 0 | Ripon (WI) | 61 | Ripon, WI | |
| 1921 | L | Carroll (WI) | 0 | Saint John's Military Academy (WI) | 10 | Waukesha, WI | |
| 1921 | L | Carroll (WI) | 0 | Wisconsin-Milwaukee | 14 | Waukesha, WI | |
| 1921 | L | Carroll (WI) | 0 | Marquette (WI) | 14 | Milwaukee, WI | |
| 1921 | L | Carroll (WI) | 7 | Beloit (WI) | 14 | Beloit, WI | |
| 1921 | L | Carrollton HS (MO) | 0 | Hannibal HS (MO) | 23 | ? | |
| 1921 | W | Carson-Newman (TN) | 7 | Bingham Military School (NC) | 0 | ? | |
| 1921 | W | Carson-Newman (TN) | 46 | East Tennessee St. | 0 | ? | |
| 1921 | L | Carson-Newman (TN) | 7 | Emory & Henry (VA) | 9 | ? | |
| 1921 | W | Carson-Newman (TN) | 17 | King College (TN) | 14 | Jefferson City, TN | |
| 1921 | W | Carson-Newman (TN) | 6 | Milligan (TN) | 0 | ? | |
| 1921 | W | Carson-Newman (TN) | 20 | Tennessee Wesleyan | 0 | ? | |
| 1921 | T | Carson-Newman (TN) | 0 | Tusculum (TN) | 0 | ? | Score unknown |
| 1921 | W | Carson-Newman (TN) | 18 | Weaver College (NC) | 0 | Jefferson City, TN | |
| 1921 | L | Carson-Newman (TN) | 0 | Maryville (TN) | 5 | Jefferson City, TN | |
| 1921 | W | Carthage (WI) | 14 | Bradley (IL) | 7 | Peoria, IL | |
| 1921 | L | Carthage (WI) | 12 | Eureka (IL) | 17 | Carthage, IL | |
| 1921 | W | Carthage (WI) | 45 | Hedding (IL) | 0 | Carthage, IL | |
| 1921 | L | Carthage (WI) | 0 | Iowa Wesleyan | 26 | Mount Pleasant, IA | |
| 1921 | W | Carthage (WI) | 21 | Western Illinois | 7 | Carthage, IL | |
| 1921 | W | Carthage (WI) | 21 | Western Illinois | 7 | Macomb, IL | |
| 1921 | W | Carthage (WI) | 48 | Quincy (IL) | 0 | Quincy, IL | |
| 1921 | W | Carthage (WI) | 28 | Lincoln College (IL) | 0 | Lincoln, IL | |
| 1921 | T | Carthage AC (TN) | 0 | Cumberland (TN) | 0 | ? | |
| 1921 | L | Carthage American Legion (MO) | 0 | Pittsburg St. (KS) | 39 | Pittsburg, KS | |
| 1921 | L | Carthage HS (IL) | 0 | Keokuk HS (IA) | 7 | ? | |
| 1921 | L | Carthage HS (IL) | 7 | Quincy HS (IL) | 23 | ? | |
| 1921 | W | Carthage HS (MO) | 19 | Joplin HS (MO) | 0 | ? | |
| 1921 | L | Caruthers HS (CA) | 7 | Fresno HS (CA) | 54 | ? | |
| 1921 | L | Cascadilla School (NY) | 0 | Wyoming Seminary (PA) | 54 | ? | |
| 1921 | W | Case Institute of Technology (OH) | 14 | Heidelberg (OH) | 7 | Tiffin, OH | |
| 1921 | W | Case Institute of Technology (OH) | 14 | Hiram (OH) | 0 | Cleveland, OH | |
| 1921 | W | Case Institute of Technology (OH) | 28 | Kenyon (OH) | 0 | Cleveland, OH | |
| 1921 | W | Case Institute of Technology (OH) | 19 | Ohio Wesleyan | 14 | Cleveland, OH | |
| 1921 | T | Case Institute of Technology (OH) | 0 | Western Reserve (OH) | 0 | Cleveland, OH | |
| 1921 | L | Case Institute of Technology (OH) | 3 | Wooster (OH) | 17 | Wooster, OH | |
| 1921 | W | Case Institute of Technology (OH) | 14 | Akron (OH) | 0 | Akron, OH | |
| 1921 | W | Case Institute of Technology (OH) | 13 | Mount Union (OH) | 7 | Alliance, OH | |
| 1921 | L | Case Institute of Technology (OH) | 0 | Michigan | 65 | Ann Arbor, MI | |
| 1921 | T | Case Institute of Technology (OH) | 7 | Oberlin (OH) | 7 | Cleveland, OH | |
| 1921 | L | Casper Independents (WY) | 0 | Casper HS (WY) | 7 | ? | |
| 1921 | L | Casselton HS (ND) | 0 | Moorhead HS (MN) | 25 | ? | |
| 1921 | L | Castle Heights Military Institute (TN) | 0 | Nashville Hume-Fogg HS (TN) | 10 | Nashville, TN | |
| 1921 | T | Castle Rock HS (WA) | 0 | James John HS (OR) | 0 | ? | |
| 1921 | L | Cathedral HS | 0 | New Jersey (NJ) | 64 | ? | |
| 1921 | L | Cathedral HS | 6 | Trenton HS (NJ) | 63 | ? | |
| 1921 | L | Cathedral Latin School (OH) | 0 | Cleveland University School (OH) | 17 | ? | |
| 1921 | L | Cathedral Latin School (OH) | 0 | Cleveland West HS (OH) | 12 | ? | |
| 1921 | L | Catholic (DC) | 0 | Bucknell (PA) | 41 | Lewisburg, PA | |
| 1921 | W | Catholic (DC) | 19 | George Washington (DC) | 7 | Washington, DC | |
| 1921 | W | Catholic (DC) | 7 | Mount Saint Mary's (MD) | 0 | Washington, DC | |
| 1921 | L | Catholic (DC) | 0 | Villanova (PA) | 7 | Washington, DC | |
| 1921 | L | Catholic (DC) | 0 | Richmond (VA) | 14 | Richmond, VA | |
| 1921 | W | Catholic (DC) | 27 | William & Mary (VA) | 13 | Newport News, VA | |
| 1921 | L | Catholic (DC) | 0 | Fordham (NY) | 10 | New York, NY | |
| 1921 | L | Catholic (DC) | 0 | Maryland | 16 | Washington, DC | |
| 1921 | L | Catlettsburg HS (KY) | 7 | Ceredo-Kenova HS (WV) | 13 | ? | |
| 1921 | L | Cavalier HS (ND) | 0 | Thief River Falls HS (MN) | 19 | ? | |
| 1921 | W | Cazenovia Seminary (NY) | 23 | Colgate Freshmen (NY) | 6 | Cazenovia, NY | |
| 1921 | W | Cazenovia Seminary (NY) | 41 | Cook Academy (NY) | 0 | ? | |
| 1921 | W | Cazenovia Seminary (NY) | 28 | Herkimer HS (NY) | 0 | ? | |
| 1921 | L | Cazenovia Seminary (NY) | 0 | Oneida HS (NY) | 42 | ? | |
| 1921 | W | Cazenovia Seminary (NY) | 21 | Rome Free Academy (NY) | 0 | Cazenovia, NY | |
| 1921 | L | Cedar Falls HS (IA) | 6 | Cedar Rapids HS (IA) | 27 | ? | |
| 1921 | L | Cedar Falls HS (IA) | 7 | Waterloo East HS (IA) | 41 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 27 | Cedar Falls HS (IA) | 6 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 38 | Central City HS (IA) | 0 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 49 | Chicago Crane Tech HS (IL) | 0 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 13 | Clarion HS (IA) | 7 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 85 | Manchester HS (IA) | 0 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 20 | Ottumwa HS (IA) | 0 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 20 | Spirit Lake HS (IA) | 0 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 32 | Valley Junction HS | 0 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 14 | Waterloo East HS (IA) | 3 | ? | |
| 1921 | W | Cedar Rapids HS (IA) | 22 | Waterloo West HS (IA) | 6 | ? | |
| 1921 | L | Cedaredge HS (CO) | 0 | Gunnison HS (CO) | 69 | ? | |
| 1921 | L | Cedaredge HS (CO) | 0 | Olathe HS (CO) | 53 | ? | |
| 1921 | L | Cedarville (OH) | 0 | Antioch (OH) | 7 | ? | |
| 1921 | W | Cedarville (OH) | 2 | Antioch (OH) | 0 | ? | |
| 1921 | L | Cedarville (OH) | 0 | Defiance (OH) | 6 | ? | Cedarville lost - score unknown |
| 1921 | L | Cedarville (OH) | 0 | Rio Grande (OH) | 6 | ? | Cedarville lost - score unknown |
| 1921 | L | Cedarville (OH) | 7 | Wilmington (OH) | 77 | ? | |
| 1921 | W | Centenary (LA) | 20 | Atlanta HS (TX) | 17 | ? | |
| 1921 | W | Centenary (LA) | 30 | College of Marshall (TX) | 0 | ? | |
| 1921 | W | Centenary (LA) | 7 | Louisiana College | 6 | ? | |
| 1921 | L | Centenary (LA) | 7 | Louisiana Tech | 14 | Shreveport, LA | |
| 1921 | W | Centenary (LA) | 21 | Millsaps (MS) | 7 | ? | |
| 1921 | L | Centenary (LA) | 0 | Northwestern St. (LA) | 7 | Shreveport, LA | |
| 1921 | L | Centenary (LA) | 0 | Saint Charles (LA) | 28 | ? | |
| 1921 | L | Centenary (LA) | 0 | Louisiana-Lafayette | 1 | Lafayette, LA | Centenary Forfeits |
| 1921 | L | Centerville HS (CA) | 8 | Potter School (CA) | 9 | ? | |
| 1921 | W | Centerville HS (CA) | 12 | San Francisco University School (CA) | 0 | ? | |
| 1921 | W | Centerville HS (IA) | 7 | Keokuk HS (IA) | 0 | ? | |
| 1921 | T | Central (IA) | 0 | Graceland (IA) | 0 | Lamoni, IA | |
| 1921 | L | Central (IA) | 0 | Kirksville Osteopath (MO) | 21 | Kirksville, MO | |
| 1921 | W | Central (IA) | 8 | William Penn (IA) | 0 | ? | |
| 1921 | L | Central (IA) | 0 | Iowa Wesleyan | 28 | Mount Pleasant, IA | |
| 1921 | W | Central (IA) | 13 | Ellsworth CC (IA) | 0 | Pella, IA | |
| 1921 | W | Central Arkansas | 13 | Arkansas St. | 7 | Jonesboro, AR | |
| 1921 | L | Central Arkansas | 0 | Arkansas Tech | 67 | Conway, AR | |
| 1921 | L | Central Arkansas | 0 | Little Rock College (AR) | 19 | Conway, AR | |
| 1921 | L | Central Arkansas | 0 | Ouachita Baptist (AR) | 58 | Arkadelphia, AR | |
| 1921 | W | Central Arkansas | 6 | Southern Arkansas | 0 | Conway, AR | |
| 1921 | L | Central Arkansas | 0 | Ozarks (AR) | 14 | Conway, AR | |
| 1921 | L | Central Arkansas | 0 | Tennessee Medical College | 28 | Memphis, TN | |
| 1921 | L | Central City HS (IA) | 0 | Cedar Rapids HS (IA) | 38 | ? | |
| 1921 | L | Central Inelig. | 13 | Wentworth Military Academy (MO) | 53 | ? | |
| 1921 | W | Central Methodist (MO) | 26 | Chillicothe Business College (MO) | 7 | Moberly, MO | |
| 1921 | L | Central Methodist (MO) | 2 | Missouri S&T | 21 | Rolla, MO | |
| 1921 | L | Central Methodist (MO) | 6 | Missouri Wesleyan | 26 | Cameron, MO | |
| 1921 | W | Central Methodist (MO) | 21 | Westminster (MO) | 7 | ? | |
| 1921 | W | Central Methodist (MO) | 7 | William Jewell (MO) | 0 | ? | |
| 1921 | W | Central Methodist (MO) | 14 | Kemper Military School (MO) | 6 | Fayette, MO | |
| 1921 | W | Central Methodist (MO) | 13 | Truman St. (MO) | 7 | Fayette, MO | |
| 1921 | W | Central Michigan | 28 | Alma (MI) | 0 | Alma, MI | |
| 1921 | W | Central Michigan | 28 | American Legion | 0 | Mount Pleasant, MI | |
| 1921 | L | Central Michigan | 6 | Eastern Michigan | 7 | Mount Pleasant, MI | |
| 1921 | W | Central Michigan | 60 | Ferris St. (MI) | 0 | Big Rapids, MI | |
| 1921 | W | Central Michigan | 7 | Ferris St. (MI) | 0 | Big Rapids, MI | |
| 1921 | W | Central Michigan | 7 | Grand Rapids JC (MI) | 0 | Grand Rapids, MI | |
| 1921 | L | Central Michigan | 10 | Hillsdale (MI) | 14 | Mount Pleasant, MI | |
| 1921 | W | Central Michigan | 17 | Hope (MI) | 0 | Mount Pleasant, MI | |
| 1921 | W | Central Michigan | 25 | Olivet (MI) | 0 | Mount Pleasant, MI | |
| 1921 | T | Central Michigan | 0 | Wayne St. (MI) | 0 | Detroit, MI | |
| 1921 | L | Central Missouri St. | 0 | Kansas City Medical (MO) | 6 | Warrensburg, MO | |
| 1921 | L | Central Missouri St. | 0 | Kemper Military School (MO) | 49 | Boonville, MO | |
| 1921 | L | Central Missouri St. | 7 | Tarkio (MO) | 41 | Tarkio, MO | |
| 1921 | L | Central Missouri St. | 0 | Truman St. (MO) | 7 | Kirksville, MO | |
| 1921 | T | Central Missouri St. | 6 | Wentworth Military Academy (MO) | 6 | Warrensburg, MO | |
| 1921 | W | Central Missouri St. | 14 | Drury (MO) | 0 | Springfield, MO | |
| 1921 | L | Central Missouri St. | 0 | William Jewell (MO) | 19 | Liberty, MO | |
| 1921 | W | Central Missouri St. | 33 | Northwest Missouri St. | 7 | Warrensburg, MO | |
| 1921 | W | Central Oklahoma | 44 | Clarendon College (TX) | 6 | ? | |
| 1921 | W | Central Oklahoma | 104 | East Central (OK) | 0 | Edmond, OK | |
| 1921 | W | Central Oklahoma | 21 | Kingfisher (OK) | 13 | ? | |
| 1921 | W | Central Oklahoma | 42 | Northwestern Oklahoma St. | 0 | ? | |
| 1921 | W | Central Oklahoma | 7 | Oklahoma Baptist University | 0 | Edmond, OK | |
| 1921 | W | Central Oklahoma | 21 | Southwestern Oklahoma St. | 14 | ? | |
| 1921 | W | Central Oklahoma | 21 | University Prep School (OK) | 0 | ? | |
| 1921 | W | Central Oklahoma | 28 | Phillips (OK) | 3 | Enid, OK | |
| 1921 | L | Central Oklahoma | 0 | Oklahoma | 21 | Norman, OK | |
| 1921 | W | Central Oklahoma | 21 | Tulsa (OK) | 0 | Tulsa, OK | |
| 1921 | W | Central Washington | 6 | Eastern Washington | 0 | Ellensburg, WA | |
| 1921 | L | Central Washington | 0 | Idaho Freshmen | 55 | Ellensburg, WA | |
| 1921 | L | Central Washington | 0 | Washington Freshmen | 31 | Ellensburg, WA | |
| 1921 | L | Central Washington | 0 | Puget Sound (WA) | 6 | Ellensburg, WA | |
| 1921 | L | Central Wesleyan (MO) | 6 | Missouri Military Academy | 28 | ? | |
| 1921 | L | Central Wesleyan (MO) | 0 | Northwest Missouri St. | 7 | ? | |
| 1921 | T | Central Wesleyan (MO) | 0 | Principia Academy (MO) | 0 | ? | |
| 1921 | L | Central Wesleyan (MO) | 0 | Westminster (MO) | 25 | Warrensburg, MO | |
| 1921 | L | Central Wesleyan (MO) | 0 | Drury (MO) | 47 | Springfield, MO | |
| 1921 | L | Centralia | 0 | Mount Carmel HS (PA) | 47 | ? | |
| 1921 | L | Centralia HS (WA) | 0 | Chehalis HS (WA) | 39 | ? | |
| 1921 | W | Centre (KY) | 38 | Arizona | 0 | San Diego, CA | San Diego E-W Christmas Classic |
| 1921 | W | Centre (KY) | 6 | Harvard (MA) | 0 | Cambridge, MA | |
| 1921 | W | Centre (KY) | 98 | Transylvania (KY) | 0 | Lexington, KY | |
| 1921 | W | Centre (KY) | 21 | Tulane (LA) | 0 | New Orleans, LA | |
| 1921 | W | Centre (KY) | 25 | Washington & Lee (VA) | 0 | Louisville, KY | |
| 1921 | W | Centre (KY) | 28 | Xavier (OH) | 6 | Cincinnati, OH | |
| 1921 | W | Centre (KY) | 63 | Texas Christian | 7 | Fort Worth, TX | Fort Worth Classic |
| 1921 | W | Centre (KY) | 14 | Clemson (SC) | 0 | Danville, KY | |
| 1921 | W | Centre (KY) | 55 | Kentucky | 0 | Danville, KY | |
| 1921 | W | Centre (KY) | 14 | Virginia Tech | 0 | Danville, KY | |
| 1921 | W | Centre (KY) | 21 | Auburn (AL) | 0 | Birmingham, AL | |
| 1921 | W | Ceredo-Kenova HS (WV) | 18 | Ashland HS (KY) | 0 | ? | |
| 1921 | W | Ceredo-Kenova HS (WV) | 13 | Catlettsburg HS (KY) | 7 | ? | |
| 1921 | W | Ceredo-Kenova HS (WV) | 13 | Catlettsburg HS (KY) | 7 | ? | |
| 1921 | L | Ceredo-Kenova HS (WV) | 0 | Charleston HS (WV) | 28 | ? | |
| 1921 | W | Ceredo-Kenova HS (WV) | 62 | Charleston JV (WV) | 6 | ? | |
| 1921 | W | Ceredo-Kenova HS (WV) | 47 | Marion HS (KY) | 0 | ? | |
| 1921 | W | Ceredo-Kenova HS (WV) | 1 | Marshall JV (WV) | 0 | ? | |
| 1921 | W | Ceredo-Kenova HS (WV) | 30 | Paintsville HS (KY) | 0 | ? | |
| 1921 | L | Ceredo-Kenova HS (WV) | 0 | Spencer HS (WV) | 14 | ? | |
| 1921 | L | Chadron HS (NE) | 0 | Alliance HS (NE) | 76 | ? | |
| 1921 | L | Chadron HS (NE) | 6 | Alliance HS (NE) | 68 | ? | |
| 1921 | L | Chadron HS (NE) | 0 | Edgemont HS (SD) | 7 | ? | |
| 1921 | L | Chadron HS (NE) | 0 | Edgemont HS (SD) | 34 | ? | |
| 1921 | W | Chadron St. (NE) | 7 | Black Hills St. (SD) | 6 | ? | |
| 1921 | L | Chadron St. (NE) | 10 | Nebraska Wesleyan | 20 | Lincoln, NE | |
| 1921 | L | Chadron St. (NE) | 12 | Wayne St. (NE) | 33 | ? | |
| 1921 | L | Chadron St. (NE) | 6 | Nebraska-Kearney | 7 | Chadron, NE | |
| 1921 | L | Chadron St. (NE) | 13 | South Dakota Tech | 20 | ? | |
| 1921 | W | Chadron St. (NE) | 6 | Black Hills St. (SD) | 0 | Deadwood, SD | |
| 1921 | W | Chaffee HS (CA) | 47 | El Monte HS (CA) | 0 | ? | |
| 1921 | L | Chaffee HS (CA) | 3 | Pomona HS (CA) | 7 | ? | |
| 1921 | T | Chaffee HS (CA) | 0 | Redlands HS (CA) | 0 | ? | |
| 1921 | W | Chaffee HS (CA) | 24 | Riverside HS (CA) | 0 | ? | |
| 1921 | W | Chaffee HS (CA) | 6 | Riverside HS (CA) | 0 | ? | |
| 1921 | W | Chaffee HS (CA) | 26 | San Bernardino HS (CA) | 0 | ? | |
| 1921 | L | Chaffee HS (CA) | 7 | Santa Ana HS (CA) | 21 | ? | |
| 1921 | W | Chaffee HS (CA) | 21 | Whittier Reform School | 7 | ? | |
| 1921 | L | Chaffey CC (CA) | 0 | San Diego St. (CA) | 14 | San Diego, CA | Balboa Stadium |
| 1921 | W | Chamberlain Hunt Academy (MS) | 20 | Greenville HS (MS) | 0 | ? | |
| 1921 | W | Chaminade College HS (MO) | 21 | Chaminade College HS Alumni (MO) | 10 | ? | |
| 1921 | W | Chaminade College HS (MO) | 7 | Clayton HS (MO) | 0 | ? | |
| 1921 | L | Chaminade College HS (MO) | 0 | Cleveland HS (MO) | 27 | ? | |
| 1921 | L | Chaminade College HS (MO) | 7 | Kirkwood HS (MO) | 13 | ? | |
| 1921 | W | Chaminade College HS (MO) | 14 | Loyola | 3 | ? | |
| 1921 | W | Chaminade College HS (MO) | 28 | Rankea Trade | 7 | ? | |
| 1921 | W | Chaminade College HS (MO) | 26 | Saint Charles HS (MO) | 0 | ? | |
| 1921 | L | Chaminade College HS (MO) | 0 | Saint Louis University Academy (MO) | 49 | ? | |
| 1921 | W | Chaminade College HS (MO) | 7 | University City HS (MO) | 0 | ? | |
| 1921 | L | Chaminade College HS Alumni (MO) | 10 | Chaminade College HS (MO) | 21 | ? | |
| 1921 | L | Chapel Hill HS (NC) | 0 | Durham HS (NC) | 14 | ? | |
| 1921 | L | Chapel Hill HS (NC) | 9 | Elon (NC) | 19 | Elon College, NC | |
| 1921 | T | Chapel Hill HS (NC) | 0 | Fayetteville HS (NC) | 0 | ? | |
| 1921 | L | Chapel Hill HS (NC) | 0 | Goldsboro HS (NC) | 27 | ? | |
| 1921 | L | Chapel Hill HS (NC) | 0 | Greensboro HS (NC) | 28 | ? | |
| 1921 | L | Chapel Hill HS (NC) | 0 | North Carolina St. Freshmen | 12 | ? | |
| 1921 | W | Chapel Hill HS (NC) | 6 | Raeford HS (NC) | 0 | ? | |
| 1921 | W | Chapel Hill HS (NC) | 7 | Trinity Park HS | 6 | ? | |
| 1921 | W | Chapel Hill HS (NC) | 9 | Trinity Park HS | 7 | ? | |
| 1921 | L | Chappell HS (NE) | 6 | Alliance HS (NE) | 61 | ? | |
| 1921 | L | Chappell HS (NE) | 6 | Yuma County HS (CO) | 59 | ? | |
| 1921 | L | Charleroi HS (PA) | 0 | North Braddock HS (PA) | 25 | ? | |
| 1921 | L | Charleroi HS (PA) | 3 | Rochester HS (PA) | 62 | ? | |
| 1921 | L | Charleroi HS (PA) | 0 | Washington HS (PA) | 92 | ? | |
| 1921 | W | Charleston (WV) | 69 | Greenbrier Military Academy (WV) | 0 | Barboursville, WV | |
| 1921 | L | Charleston (WV) | 14 | Ironton Tanks | 19 | ? | |
| 1921 | L | Charleston (WV) | 0 | Ohio | 40 | Athens, OH | |
| 1921 | W | Charleston (WV) | 33 | Rio Grande (OH) | 0 | Barboursville, WV | |
| 1921 | L | Charleston (WV) | 7 | Washington & Lee (VA) | 33 | Lexington, VA | |
| 1921 | W | Charleston (WV) | 21 | West Virginia Tech | 0 | ? | |
| 1921 | L | Charleston (WV) | 7 | Xavier (OH) | 21 | Cincinnati, OH | |
| 1921 | L | Charleston (WV) | 7 | Virginia Tech | 54 | Blacksburg, VA | |
| 1921 | W | Charleston (WV) | 21 | Davis & Elkins (WV) | 0 | Barboursville, WV | |
| 1921 | W | Charleston (WV) | 27 | Kentucky Wesleyan | 0 | Barboursville, WV | |
| 1921 | L | Charleston HS (AR) | 0 | Van Buren HS (AR) | 110 | ? | |
| 1921 | W | Charleston HS (MO) | 17 | Marvin College (MO) | 6 | ? | |
| 1921 | W | Charleston HS (MO) | 26 | Marvin College (MO) | 6 | ? | |
| 1921 | W | Charleston HS (MS) | 13 | Grenada HS (MS) | 0 | ? | |
| 1921 | W | Charleston HS (SC) | 27 | Camden HS (SC) | 0 | ? | |
| 1921 | W | Charleston HS (SC) | 34 | Chester HS (SC) | 0 | ? | |
| 1921 | W | Charleston HS (SC) | 28 | Columbia HS (SC) | 14 | ? | |
| 1921 | W | Charleston HS (SC) | 54 | Darlington HS (SC) | 0 | ? | |
| 1921 | W | Charleston HS (SC) | 61 | Florence HS (SC) | 0 | ? | |
| 1921 | L | Charleston HS (SC) | 3 | Jacksonville Duval HS (FL) | 21 | ? | |
| 1921 | W | Charleston HS (SC) | 68 | Lake City HS (FL) | 0 | ? | |
| 1921 | W | Charleston HS (SC) | 51 | Orangeburg HS (SC) | 0 | ? | |
| 1921 | W | Charleston HS (SC) | 13 | Peabody HS (MA) | 6 | ? | |
| 1921 | W | Charleston HS (SC) | 38 | Sumter HS (SC) | 0 | ? | |
| 1921 | W | Charleston HS (SC) | 33 | Timmonsville HS (SC) | 0 | ? | |
| 1921 | T | Charleston HS (WV) | 6 | Buckhannon HS (WV) | 6 | ? | |
| 1921 | W | Charleston HS (WV) | 28 | Ceredo-Kenova HS (WV) | 0 | ? | |
| 1921 | W | Charleston HS (WV) | 20 | East Bank HS (WV) | 0 | ? | |
| 1921 | L | Charleston HS (WV) | 6 | Elkins HS (WV) | 18 | ? | |
| 1921 | L | Charleston HS (WV) | 6 | Greenbrier Military Academy (WV) | 7 | Lewisburg, WV | |
| 1921 | W | Charleston HS (WV) | 34 | Hinton HS (WV) | 0 | ? | |
| 1921 | L | Charleston HS (WV) | 0 | Huntington HS (WV) | 7 | ? | |
| 1921 | L | Charleston HS (WV) | 7 | Parkersburg HS (WV) | 47 | ? | |
| 1921 | W | Charleston HS (WV) | 20 | Saint Albans HS | 0 | ? | |
| 1921 | L | Charleston HS (WV) | 7 | Wheeling HS (WV) | 14 | ? | |
| 1921 | L | Charleston JV (WV) | 6 | Ceredo-Kenova HS (WV) | 62 | ? | |
| 1921 | L | Charlestown HS (MA) | 0 | Boston Hyde Park HS (MA) | 24 | ? | |
| 1921 | W | Charlotte Hall Military Academy (MD) | 24 | Rock Hill College (MD) | 3 | ? | |
| 1921 | L | Charlotte Hall Military Academy (MD) | 0 | Severn School (MD) | 14 | ? | |
| 1921 | L | Charlotte Hall Military Academy (MD) | 0 | Washington Central HS (DC) | 27 | Washington, DC | |
| 1921 | W | Charlotte HS | 20 | Bingham Military School (NC) | 7 | ? | |
| 1921 | L | Charlotte HS (MI) | 0 | Albion HS (MI) | 41 | ? | |
| 1921 | L | Charlotte HS (MI) | 0 | Marshall HS (MI) | 100 | ? | |
| 1921 | W | Charlotte University School (NC) | 33 | Lenoir-Rhyne (NC) | 14 | ? | |
| 1921 | W | Charlotte University School (NC) | 3 | Weaver College (NC) | 0 | ? | |
| 1921 | L | Charlottesville HS (VA) | 0 | Roanoke HS (VA) | 34 | ? | |
| 1921 | L | Charlottesville HS (VA) | 0 | Virginia Episcopal School (VA) | 13 | ? | |
| 1921 | L | Chatfield HS (MN) | 0 | Lanesboro HS (MN) | 61 | ? | |
| 1921 | L | Chatham Academy | 0 | Porter Military Academy (SC) | 14 | ? | |
| 1921 | W | Chatham HS (NJ) | 13 | Bernards HS (NJ) | 6 | ? | |
| 1921 | L | Chatham HS (NJ) | 13 | Bernards HS (NJ) | 19 | ? | |
| 1921 | L | Chatham HS (NJ) | 0 | Dover HS (NJ) | 7 | ? | |
| 1921 | W | Chatham HS (NJ) | 41 | Montclair HS JV (NJ) | 0 | ? | |
| 1921 | W | Chatham HS (NJ) | 13 | Newark Academy (NJ) | 6 | ? | |
| 1921 | W | Chatham HS (NJ) | 12 | Rahway HS (NJ) | 0 | ? | |
| 1921 | W | Chatham HS (NJ) | 20 | Summit HS (NJ) | 6 | ? | |
| 1921 | W | Chatham HS (NJ) | 7 | West Orange HS (NJ) | 0 | ? | |
| 1921 | L | Chatham Training School (VA) | 12 | Blackstone Military Academy (VA) | 33 | ? | |
| 1921 | L | Chatham Training School (VA) | 0 | Fork Union Military Academy (VA) | 14 | ? | |
| 1921 | W | Chatham Training School (VA) | 39 | Lynchburg JV (VA) | 0 | ? | |
| 1921 | T | Chatham Training School (VA) | 13 | Nor. & West (Ath.) | 13 | ? | |
| 1921 | W | Chatham Training School (VA) | 14 | Oak Ridge Military Academy (TN) | 0 | ? | |
| 1921 | W | Chatham Training School (VA) | 39 | Randolph-Macon Academy (VA) | 8 | ? | |
| 1921 | W | Chatham Training School (VA) | 19 | Salem HS (VA) | 7 | ? | |
| 1921 | L | Chattanooga Central HS (TN) | 0 | Baylor Military Academy (TN) | 7 | ? | |
| 1921 | W | Chehalis HS (WA) | 8 | Aberdeen HS (WA) | 0 | ? | |
| 1921 | W | Chehalis HS (WA) | 39 | Centralia HS (WA) | 0 | ? | |
| 1921 | W | Chehalis HS (WA) | 22 | Chehalis HS Alumni (WA) | 7 | ? | |
| 1921 | W | Chehalis HS (WA) | 7 | Hoquiam HS (WA) | 0 | ? | |
| 1921 | W | Chehalis HS (WA) | 6 | Montesano HS (WA) | 0 | ? | |
| 1921 | W | Chehalis HS (WA) | 27 | Olympia HS (WA) | 0 | ? | |
| 1921 | W | Chehalis HS (WA) | 39 | Puget Sound Freshmen (WA) | 14 | ? | |
| 1921 | W | Chehalis HS (WA) | 3 | Saint Martin's (WA) | 0 | ? | |
| 1921 | W | Chehalis HS (WA) | 16 | Vancouver HS (WA) | 0 | ? | |
| 1921 | L | Chehalis HS Alumni (WA) | 7 | Chehalis HS (WA) | 22 | ? | |
| 1921 | L | Chelsea HS (MA) | 0 | Gloucester HS (MA) | 30 | ? | |
| 1921 | L | Chelsea HS (MA) | 0 | Marblehead HS (MA) | 74 | ? | |
| 1921 | L | Chelsea HS (MA) | 0 | Marquand School (NY) | 26 | ? | |
| 1921 | L | Chelsea HS (MA) | 0 | Peabody HS (MA) | 1 | ? | |
| 1921 | L | Chelsea HS (MA) | 0 | Revere HS (MA) | 33 | ? | |
| 1921 | L | Chelsea HS (MI) | 0 | Tecumseh HS (MI) | 27 | ? | |
| 1921 | L | Chelsea HS (MI) | 0 | Tecumseh HS (MI) | 88 | ? | |
| 1921 | L | Cheltenham HS (PA) | 0 | Abington HS (PA) | 14 | Abington, PA | |
| 1921 | L | Cheltenham HS (PA) | 0 | Camden HS (NJ) | 21 | ? | |
| 1921 | W | Cheltenham HS (PA) | 6 | Coatesville HS (PA) | 0 | ? | |
| 1921 | L | Cheltenham HS (PA) | 0 | Darby HS (PA) | 14 | ? | |
| 1921 | W | Cheltenham HS (PA) | 14 | Lansdowne HS (PA) | 7 | ? | |
| 1921 | L | Cheltenham HS (PA) | 0 | Lower Merion HS (PA) | 13 | ? | |
| 1921 | L | Cheltenham HS (PA) | 0 | Radnor HS (PA) | 39 | ? | |
| 1921 | W | Cheltenham HS (PA) | 31 | Swarthmore HS (PA) | 0 | ? | |
| 1921 | L | Chemawa Indian School (OR) | 0 | Pacific (OR) | 14 | Forest Grove, OR | |
| 1921 | L | Chemawa Indian School (OR) | 7 | Willamette (OR) | 14 | Salem, OR | |
| 1921 | L | Chemawa Indian School (OR) | 0 | Oregon St. | 68 | Corvallis, OR | |
| 1921 | L | Cherryvale HS (KS) | 0 | Independence HS (KS) | 34 | ? | |
| 1921 | L | Chester HS (PA) | 0 | Coatesville HS (PA) | 6 | ? | |
| 1921 | T | Chester HS (PA) | 7 | Darby HS (PA) | 7 | ? | |
| 1921 | W | Chester HS (PA) | 3 | Lansdowne HS (PA) | 0 | ? | |
| 1921 | W | Chester HS (PA) | 14 | Media HS (PA) | 7 | ? | |
| 1921 | L | Chester HS (PA) | 0 | Monaca HS (PA) | 20 | ? | |
| 1921 | T | Chester HS (PA) | 7 | Ridley Park HS (PA) | 7 | ? | |
| 1921 | W | Chester HS (PA) | 25 | Salesianum HS (DE) | 7 | ? | |
| 1921 | W | Chester HS (PA) | 7 | West Chester HS (PA) | 6 | ? | |
| 1921 | W | Chester HS (PA) | 13 | Wilmington HS (DE) | 6 | ? | |
| 1921 | L | Chester HS (SC) | 0 | Charleston HS (SC) | 34 | ? | |
| 1921 | L | Chester HS (WV) | 7 | Triadelphia HS (WV) | 10 | ? | |
| 1921 | L | Chestertown HS (MD) | 3 | Newark HS (DE) | 14 | ? | |
| 1921 | L | Chestnut Hill Academy (PA) | 7 | Episcopal Academy (PA) | 36 | ? | |
| 1921 | W | Chestnut Hill Academy (PA) | 28 | Friends Central School (PA) | 0 | ? | |
| 1921 | L | Chestnut Hill Academy (PA) | 0 | Germantown Academy (PA) | 28 | ? | |
| 1921 | L | Chestnut Hill Academy (PA) | 0 | Germantown Friends School (PA) | 39 | ? | |
| 1921 | L | Chestnut Hill Academy (PA) | 7 | Penn Charter School (PA) | 27 | ? | |
| 1921 | L | Chestnut Hill Academy (PA) | 6 | Pennsylvania Institution for the Deaf | 27 | ? | |
| 1921 | L | Chestnut Hill Academy (PA) | 7 | Saint Luke's School (PA) | 14 | ? | |
| 1921 | W | Cheyenne HS (WY) | 31 | Casper HS (WY) | 20 | ? | |
| 1921 | L | Cheyenne HS (WY) | 0 | Colorado Springs HS (CO) | 45 | ? | |
| 1921 | L | Cheyenne HS (WY) | 0 | Laramie HS (WY) | 3 | ? | |
| 1921 | L | Cheyenne HS (WY) | 0 | Laramie HS (WY) | 10 | ? | |
| 1921 | L | Cheyney (PA) | 6 | Washington Dunbar HS (DC) | 13 | ? | |
| 1921 | W | Chicago (IL) | 35 | Colorado | 0 | Chicago, IL | |
| 1921 | W | Chicago (IL) | 9 | Princeton (NJ) | 0 | Princeton, NJ | |
| 1921 | W | Chicago (IL) | 3 | Wisconsin | 0 | Chicago, IL | |
| 1921 | W | Chicago (IL) | 41 | Northwestern (IL) | 0 | Chicago, IL | |
| 1921 | L | Chicago (IL) | 0 | Ohio St. | 7 | Chicago, IL | |
| 1921 | W | Chicago (IL) | 9 | Purdue (IN) | 0 | Chicago, IL | |
| 1921 | W | Chicago (IL) | 14 | Illinois | 6 | Champaign, IL | |
| 1921 | W | Chicago Austin HS (IL) | 6 | Chicago Carl Schurz HS (IL) | 0 | ? | |
| 1921 | L | Chicago Austin HS (IL) | 0 | Chicago Lane Tech HS (IL) | 13 | ? | |
| 1921 | W | Chicago Austin HS (IL) | 7 | Chicago Nicholas Senn HS (IL) | 0 | ? | |
| 1921 | L | Chicago Austin HS (IL) | 6 | Proviso Township HS (IL) | 14 | ? | |
| 1921 | W | Chicago Bowen HS (IL) | 21 | Chicago Hyde Park HS (IL) | 7 | ? | |
| 1921 | W | Chicago Bowen HS (IL) | 14 | Chicago Parker HS (IL) | 0 | ? | |
| 1921 | W | Chicago Bowen HS (IL) | 7 | Marshall HS (IL) | 6 | ? | |
| 1921 | T | Chicago Bowen HS (IL) | 0 | Morgan Park Military Academy (IL) | 0 | ? | |
| 1921 | W | Chicago Bowen HS (IL) | 12 | Pullman Tech (IL) | 0 | ? | |
| 1921 | W | Chicago Bowen HS (IL) | 41 | Thornton HS (IL) | 0 | ? | |
| 1921 | W | Chicago Bowen HS (IL) | 3 | Tilden HS (WI) | 0 | ? | |
| 1921 | W | Chicago Bowen HS (IL) | 9 | Tilden HS (WI) | 0 | ? | |
| 1921 | L | Chicago Carl Schurz HS (IL) | 3 | Benton HS (IL) | 27 | ? | |
| 1921 | L | Chicago Carl Schurz HS (IL) | 0 | Chicago Austin HS (IL) | 6 | ? | |
| 1921 | W | Chicago Carl Schurz HS (IL) | 13 | Chicago Crane Tech HS (IL) | 7 | ? | |
| 1921 | W | Chicago Carl Schurz HS (IL) | 7 | Chicago Lane Tech HS (IL) | 6 | ? | |
| 1921 | L | Chicago Carl Schurz HS (IL) | 3 | Chicago Nicholas Senn HS (IL) | 7 | ? | |
| 1921 | W | Chicago Carl Schurz HS (IL) | 7 | Woodstock HS (IL) | 0 | ? | |
| 1921 | L | Chicago Crane Tech HS (IL) | 0 | Cedar Rapids HS (IA) | 49 | ? | |
| 1921 | L | Chicago Crane Tech HS (IL) | 7 | Chicago Carl Schurz HS (IL) | 13 | ? | |
| 1921 | W | Chicago Crane Tech HS (IL) | 20 | Chicago Lane Tech HS (IL) | 0 | ? | |
| 1921 | W | Chicago Crane Tech HS (IL) | 20 | Chicago Nicholas Senn HS (IL) | 0 | ? | |
| 1921 | L | Chicago East Side HS (IL) | 7 | Gary Froebel HS (IN) | 13 | ? | |
| 1921 | L | Chicago East Side HS (IL) | 0 | La Grange HS (IL) | 35 | ? | |
| 1921 | L | Chicago Englewood HS (IL) | 0 | Chicago Hyde Park HS (IL) | 6 | ? | |
| 1921 | L | Chicago Englewood HS (IL) | 7 | Chicago Lindblom HS (IL) | 13 | ? | |
| 1921 | L | Chicago Englewood HS (IL) | 7 | Dayton Steele HS (OH) | 24 | ? | |
| 1921 | W | Chicago Englewood HS (IL) | 56 | Gridley HS (IL) | 0 | ? | |
| 1921 | T | Chicago Englewood HS (IL) | 0 | Harrison HS | 0 | ? | |
| 1921 | W | Chicago Englewood HS (IL) | 13 | Mooseheart HS (IL) | 7 | ? | |
| 1921 | L | Chicago Hyde Park HS (IL) | 7 | Chicago Bowen HS (IL) | 21 | ? | |
| 1921 | W | Chicago Hyde Park HS (IL) | 6 | Chicago Englewood HS (IL) | 0 | ? | |
| 1921 | T | Chicago Hyde Park HS (IL) | 7 | Elgin HS (IL) | 7 | ? | |
| 1921 | W | Chicago Lane Tech HS (IL) | 13 | Chicago Austin HS (IL) | 0 | ? | |
| 1921 | L | Chicago Lane Tech HS (IL) | 6 | Chicago Carl Schurz HS (IL) | 7 | ? | |
| 1921 | L | Chicago Lane Tech HS (IL) | 0 | Chicago Crane Tech HS (IL) | 20 | ? | |
| 1921 | W | Chicago Lane Tech HS (IL) | 12 | Chicago Nicholas Senn HS (IL) | 0 | ? | |
| 1921 | L | Chicago Lane Tech HS (IL) | 0 | Fostoria HS (OH) | 21 | ? | |
| 1921 | L | Chicago Latin School (IL) | 0 | Chicago Nicholas Senn HS (IL) | 14 | ? | |
| 1921 | W | Chicago Lindblom HS (IL) | 13 | Chicago Englewood HS (IL) | 7 | ? | |
| 1921 | L | Chicago Lindblom HS (IL) | 6 | Deerfield Shields HS (IL) | 14 | ? | |
| 1921 | L | Chicago Parker HS (IL) | 0 | Chicago Bowen HS (IL) | 14 | ? | |
| 1921 | W | Chicago YMCA College (IL) | 50 | DePaul (IL) | 0 | ? | |
| 1921 | W | Chicago YMCA College (IL) | 7 | Western Michigan | 3 | Kalamazoo, MI | |
| 1921 | W | Chicago YMCA College (IL) | 56 | Wheaton (IL) | 0 | Chicago, IL | |
| 1921 | W | Chicago YMCA College (IL) | 14 | Butler (IN) | 7 | Indianapolis, IN | |
| 1921 | W | Chicago YMCA College (IL) | 7 | Lake Forest (IL) | 0 | Lake Forest, IL | |
| 1921 | W | Chicago YMCA College (IL) | 20 | North Central (IL) | 0 | Naperville, IL | |
| 1921 | L | Chickasha HS (OK) | 7 | Terrill Prep School (TX) | 28 | ? | |
| 1921 | W | Chickasha HS (OK) | 83 | Cameron (OK) | 0 | ? | |
| 1921 | L | Chico HS (CA) | 7 | Cal St.-Chico | 21 | ? | |
| 1921 | L | Chico HS (CA) | 0 | Glenn County HS (CA) | 26 | ? | |
| 1921 | W | Chicopee HS (MA) | 6 | Bridgeport HS (CT) | 2 | ? | |
| 1921 | L | Chicopee HS (MA) | 0 | Crosby HS (CT) | 14 | ? | |
| 1921 | L | Chillicothe Business College (MO) | 7 | Central Methodist (MO) | 26 | Moberly, MO | |
| 1921 | W | Chillicothe Business College (MO) | 34 | Excelsior Springs AA (MO) | 0 | Chillicothe, MO | |
| 1921 | W | Chillicothe Business College (MO) | 19 | Graceland (IA) | 3 | Chillicothe, MO | |
| 1921 | L | Chillicothe Business College (MO) | 6 | Kemper Military School (MO) | 7 | ? | |
| 1921 | W | Chillicothe Business College (MO) | 14 | Missouri Military Academy | 6 | Mexico, MO | |
| 1921 | W | Chillicothe Business College (MO) | 14 | Wentworth Military Academy (MO) | 0 | Chillicothe, MO | |
| 1921 | W | Chillicothe Business College (MO) | 19 | Benedictine (KS) | 14 | Atchison, KS | |
| 1921 | L | Chillicothe Business College (MO) | 0 | Kirksville Osteopath (MO) | 41 | Kirksville, MO | |
| 1921 | L | Chillicothe HS (OH) | 0 | Columbus East HS (OH) | 7 | ? | |
| 1921 | W | Chillicothe HS (OH) | 47 | Greenfield HS (OH) | 0 | ? | |
| 1921 | W | Chillicothe HS (OH) | 7 | Hillsboro HS (OH) | 0 | ? | |
| 1921 | W | Chillicothe HS (OH) | 14 | Ironton HS (OH) | 13 | ? | |
| 1921 | L | Chillicothe HS (OH) | 7 | Lancaster HS (OH) | 12 | ? | |
| 1921 | W | Chillicothe HS (OH) | 7 | Portsmouth HS (OH) | 0 | ? | |
| 1921 | W | Chillicothe HS (OH) | 33 | Washington Court House HS (OH) | 0 | ? | |
| 1921 | W | Chillicothe HS (OH) | 6 | Wilmington HS (OH) | 2 | ? | |
| 1921 | L | Chilocco Indian School (OK) | 0 | Bethany (KS) | 20 | Lindsborg, KS | |
| 1921 | L | Chilocco Indian School (OK) | 0 | McPherson (KS) | 35 | McPherson, KS | |
| 1921 | T | Chilocco Indian School (OK) | 0 | Oklahoma Baptist University | 0 | Chilocco, OK | |
| 1921 | W | Chilocco Indian School (OK) | 20 | Oklahoma City (OK) | 14 | Oklahoma City, OK | |
| 1921 | L | Chilocco Indian School (OK) | 0 | Southwestern (KS) | 28 | Winfield, KS | |
| 1921 | L | Chilocco Indian School (OK) | 13 | Tulsa (OK) | 75 | Tulsa, OK | |
| 1921 | W | Choate School | 49 | Pawling School (NY) | 0 | ? | |
| 1921 | L | Choate School | 0 | Pomfret School (CT) | 7 | ? | |
| 1921 | W | Choate School | 3 | Roxbury School (CT) | 0 | ? | |
| 1921 | W | Christian Brothers (TN) | 25 | Memphis (TN) | 13 | Memphis, TN | |
| 1921 | T | Christian Brothers (TN) | 0 | Memphis Central HS (TN) | 0 | ? | |
| 1921 | L | Christian Brothers Academy (NY) | 14 | Saint John's Military Academy (NY) | 60 | Manlius, NY | |
| 1921 | L | Christiansburg Institute (VA) | 0 | Roanoke HS (VA) | 25 | ? | |
| 1921 | L | Christiansburg Institute (VA) | 0 | Salem HS (VA) | 41 | ? | |
| 1921 | W | Cincinnati (OH) | 115 | Kentucky Wesleyan | 0 | Cincinnati, OH | |
| 1921 | L | Cincinnati (OH) | 7 | Miami (OH) | 15 | Cincinnati, OH | |
| 1921 | L | Cincinnati (OH) | 14 | Pittsburgh (PA) | 21 | Pittsburgh, PA | |
| 1921 | W | Cincinnati (OH) | 20 | Toledo (OH) | 0 | Cincinnati, OH | |
| 1921 | L | Cincinnati (OH) | 2 | Wittenberg (OH) | 7 | Cincinnati, OH | |
| 1921 | L | Cincinnati (OH) | 0 | West Virginia | 50 | Morgantown, WV | |
| 1921 | L | Cincinnati (OH) | 6 | Ohio | 7 | Athens, OH | |
| 1921 | W | Cincinnati (OH) | 17 | Baldwin-Wallace (OH) | 7 | Cincinnati, OH | |
| 1921 | L | Cincinnati (OH) | 0 | Denison (OH) | 7 | Cincinnati, OH | |
| 1921 | L | Cincinnati East HS (OH) | 14 | Cincinnati Hughes HS (OH) | 32 | ? | |
| 1921 | L | Cincinnati East HS (OH) | 6 | Cincinnati Norwood HS (OH) | 7 | ? | |
| 1921 | W | Cincinnati East HS (OH) | 20 | Cincinnati Walnut Hills HS (OH) | 0 | ? | |
| 1921 | W | Cincinnati East HS (OH) | 29 | Cincinnati Woodward HS (OH) | 13 | ? | |
| 1921 | W | Cincinnati East HS (OH) | 7 | Hamilton HS (OH) | 0 | ? | |
| 1921 | W | Cincinnati East HS (OH) | 74 | Highlands HS | 0 | ? | |
| 1921 | W | Cincinnati East HS (OH) | 35 | Ohio Military Institute | 0 | ? | |
| 1921 | W | Cincinnati Hughes HS (OH) | 32 | Cincinnati East HS (OH) | 14 | ? | |
| 1921 | T | Cincinnati Hughes HS (OH) | 0 | Cincinnati Norwood HS (OH) | 0 | ? | |
| 1921 | W | Cincinnati Hughes HS (OH) | 70 | Cincinnati Walnut Hills HS (OH) | 0 | ? | |
| 1921 | W | Cincinnati Hughes HS (OH) | 39 | Cincinnati Woodward HS (OH) | 0 | ? | |
| 1921 | W | Cincinnati Hughes HS (OH) | 34 | Greenfield HS (OH) | 0 | ? | |
| 1921 | W | Cincinnati Hughes HS (OH) | 25 | Louisville Saint Xavier HS (KY) | 0 | ? | |
| 1921 | L | Cincinnati Hughes HS (OH) | 27 | Middletown HS (OH) | 31 | ? | |
| 1921 | W | Cincinnati Hughes HS (OH) | 40 | Milford HS (OH) | 0 | ? | |
| 1921 | W | Cincinnati Norwood HS (OH) | 7 | Cincinnati East HS (OH) | 6 | ? | |
| 1921 | T | Cincinnati Norwood HS (OH) | 0 | Cincinnati Hughes HS (OH) | 0 | ? | |
| 1921 | L | Cincinnati Walnut Hills HS (OH) | 0 | Cincinnati East HS (OH) | 20 | ? | |
| 1921 | L | Cincinnati Walnut Hills HS (OH) | 0 | Cincinnati Hughes HS (OH) | 70 | ? | |
| 1921 | L | Cincinnati Woodward HS (OH) | 13 | Cincinnati East HS (OH) | 29 | ? | |
| 1921 | L | Cincinnati Woodward HS (OH) | 0 | Cincinnati Hughes HS (OH) | 39 | ? | |
| 1921 | L | Cincinnati Woodward HS (OH) | 0 | Miami Military Institute (OH) | 26 | ? | |
| 1921 | L | Circleville HS (OH) | 0 | Wilmington HS (OH) | 6 | ? | |
| 1921 | L | Citadel (SC) | 6 | Erskine (SC) | 13 | Due West, SC | |
| 1921 | L | Citadel (SC) | 0 | Furman (SC) | 42 | Greenville, SC | |
| 1921 | W | Citadel (SC) | 20 | Presbyterian (SC) | 0 | Clinton, SC | |
| 1921 | L | Citadel (SC) | 0 | South Carolina | 13 | Columbia, SC | |
| 1921 | W | Citadel (SC) | 37 | Parris Island Marines (SC) | 0 | Charleston, SC | |
| 1921 | T | Citadel (SC) | 7 | Newberry (SC) | 7 | Newberry, SC | |
| 1921 | W | Citadel (SC) | 28 | Wofford (SC) | 0 | Charleston, SC | |
| 1921 | T | Citadel (SC) | 7 | Clemson (SC) | 7 | Orangeburg, SC | |
| 1921 | L | Citrus Union HS (CA) | 0 | San Diego HS (CA) | 49 | ? | |
| 1921 | W | Citrus Union HS (CA) | 7 | South Pasadena HS (CA) | 0 | ? | |
| 1921 | L | Clairton HS (PA) | 0 | Duquesne HS (PA) | 21 | ? | |
| 1921 | L | Claremont Stevens HS (NH) | 0 | Colby Academy (NH) | 21 | ? | |
| 1921 | W | Clarendon College (TX) | 7 | Abilene Christian (TX) | 0 | Clarendon, TX | |
| 1921 | L | Clarendon College (TX) | 6 | Central Oklahoma | 44 | ? | |
| 1921 | L | Clarendon College (TX) | 3 | John Tarleton College (TX) | 34 | ? | |
| 1921 | T | Clarendon College (TX) | 14 | West Texas A&M | 14 | Canyon, TX | |
| 1921 | W | Clarendon College (TX) | 9 | West Texas A&M | 0 | Clarendon, TX | |
| 1921 | W | Clarendon College (TX) | 34 | Wayland Baptist (TX) | 0 | Plainview, TX | |
| 1921 | W | Clarion (PA) | 6 | DuBois HS (PA) | 0 | DuBois, PA | |
| 1921 | L | Clarion (PA) | 0 | Oil City HS (PA) | 7 | Oil City, PA | West End Park |
| 1921 | W | Clarion (PA) | 14 | California (PA) | 13 | Clarion, PA | |
| 1921 | W | Clarion (PA) | 12 | Clearfield HS (PA) | 0 | Clarion, PA | |
| 1921 | L | Clarion (PA) | 0 | Indiana (PA) | 7 | Clarion, PA | Pinks Field |
| 1921 | L | Clarion HS (IA) | 7 | Cedar Rapids HS (IA) | 13 | ? | |
| 1921 | L | Clark Atlanta (GA) | 0 | Atlanta (GA) | 19 | ? | |
| 1921 | L | Clark Atlanta (GA) | 0 | Knox Institute (GA) | 10 | ? | |
| 1921 | W | Clark Atlanta (GA) | 10 | Knoxville (TN) | 0 | ? | |
| 1921 | L | Clark HS (SD) | 6 | Aberdeen HS (SD) | 21 | ? | |
| 1921 | W | Clark HS (SD) | 20 | Brookings HS (SD) | 0 | ? | |
| 1921 | W | Clark HS (SD) | 13 | De Smet HS (SD) | 7 | ? | |
| 1921 | W | Clark HS (SD) | 33 | Huron HS (SD) | 0 | ? | |
| 1921 | W | Clark HS (SD) | 35 | Redfield HS (SD) | 12 | ? | |
| 1921 | W | Clark HS (SD) | 7 | Redfield HS (SD) | 0 | ? | |
| 1921 | W | Clark HS (SD) | 1 | Toronto | 0 | ? | Toronto Forfeits |
| 1921 | L | Clark HS (SD) | 7 | Watertown HS (SD) | 13 | ? | |
| 1921 | W | Clark HS (SD) | 50 | Webster HS (SD) | 0 | ? | |
| 1921 | W | Clarke County HS (AL) | 26 | Jackson Agricultural School (AL) | 0 | ? | |
| 1921 | W | Clarkesville A&M School (GA) | 6 | Piedmont (GA) | 0 | ? | Clarkesville A&M School won - score unknown |
| 1921 | L | Clarksburg HS (WV) | 7 | Buckhannon HS (WV) | 13 | ? | |
| 1921 | W | Clarksburg HS (WV) | 26 | Fairmont HS (WV) | 0 | ? | |
| 1921 | W | Clarksburg HS (WV) | 14 | Huntington HS (WV) | 13 | ? | |
| 1921 | L | Clarksburg Victory HS (WV) | 0 | Buckhannon HS (WV) | 34 | ? | |
| 1921 | L | Clarksburg Victory HS (WV) | 0 | Elkins HS (WV) | 25 | ? | |
| 1921 | L | Clarksburg Victory HS (WV) | 0 | Fairmont HS (WV) | 7 | ? | |
| 1921 | L | Clarksburg Victory HS (WV) | 0 | Grafton HS (WV) | 7 | ? | |
| 1921 | L | Clarksburg Victory HS (WV) | 0 | Mannington HS (WV) | 20 | ? | |
| 1921 | L | Clarksburg Victory HS (WV) | 0 | Washington Irving HS (WV) | 35 | ? | |
| 1921 | L | Clarksburg Victory HS (WV) | 7 | Weston HS (WV) | 13 | ? | |
| 1921 | W | Clarksdale HS (MS) | 41 | Cleveland HS (MS) | 0 | ? | |
| 1921 | W | Clarksdale HS (MS) | 26 | Greenville HS (MS) | 0 | ? | |
| 1921 | W | Clarksdale HS (MS) | 27 | Greenwood HS (MS) | 0 | ? | |
| 1921 | W | Clarksdale HS (MS) | 26 | Moorhead Agriculture (MS) | 21 | ? | |
| 1921 | T | Clarksdale HS (MS) | 0 | New Albany HS (MS) | 0 | ? | |
| 1921 | W | Clarksdale HS (MS) | 51 | Senatobia Agriculture HS (MS) | 7 | ? | |
| 1921 | W | Clarksdale HS (MS) | 65 | Tunica Agriculture (MS) | 0 | ? | |
| 1921 | L | Clarkson (NY) | 0 | Hobart (NY) | 24 | Geneva, NY | |
| 1921 | L | Clarkson (NY) | 0 | Norwich (VT) | 39 | Northfield, VT | |
| 1921 | W | Clarkson (NY) | 6 | Rochester (NY) | 0 | Potsdam, NY | |
| 1921 | W | Clarkson (NY) | 45 | Rochester Optometry (NY) | 0 | Potsdam, NY | |
| 1921 | W | Clarkson (NY) | 45 | Rochester Tech (NY) | 0 | Potsdam, NY | |
| 1921 | L | Clarkson (NY) | 0 | Union (NY) | 14 | Schenectady, NY | |
| 1921 | L | Clarkson (NY) | 0 | Middlebury (VT) | 14 | Middlebury, VT | |
| 1921 | T | Clarkson (NY) | 0 | Hamilton (NY) | 0 | Clinton, NY | |
| 1921 | W | Clarkson (NY) | 9 | Saint Lawrence (NY) | 0 | Canton, NY | |
| 1921 | L | Clarksville HS (AR) | 0 | Russellville HS (AR) | 7 | ? | |
| 1921 | L | Clarksville HS (TN) | 0 | Nashville Hume-Fogg HS (TN) | 14 | ? | |
| 1921 | W | Clason Military Academy (NY) | 21 | All Hallows Institute | 7 | ? | |
| 1921 | W | Clason Military Academy (NY) | 21 | Hamilton Institute (NY) | 0 | ? | |
| 1921 | T | Clason Military Academy (NY) | 0 | New York Morris HS (NY) | 0 | ? | |
| 1921 | W | Clason Military Academy (NY) | 20 | Saint Francis Prep (NY) | 0 | ? | |
| 1921 | W | Clason Military Academy (NY) | 14 | Saint Francis Xavier (NY) | 0 | ? | |
| 1921 | L | Clason Military Academy (NY) | 0 | Saint Peter's Prep (NJ) | 20 | ? | |
| 1921 | L | Clason Military Academy (NY) | 0 | Stuyvesant HS (NY) | 6 | ? | |
| 1921 | W | Clason Military Academy (NY) | 38 | McBurney School | 0 | Bronx, NY | |
| 1921 | W | Clason Military Academy (NY) | 7 | Marquand School (NY) | 6 | ? | |
| 1921 | L | Clay Center HS (NE) | 0 | Cambridge HS (NE) | 41 | ? | |
| 1921 | W | Clayton HS (NM) | 67 | Clayton Legion (NM) | 0 | ? | |
| 1921 | W | Clayton HS (NM) | 31 | Clayton Town Team (NM) | 0 | ? | |
| 1921 | W | Clayton HS (NM) | 13 | Dalhart HS (TX) | 6 | ? | |
| 1921 | W | Clayton HS (NM) | 12 | Dalhart HS (TX) | 0 | ? | |
| 1921 | W | Clayton HS (NM) | 34 | Raton HS (NM) | 7 | ? | |
| 1921 | W | Clayton HS (NM) | 6 | Raton HS (NM) | 0 | ? | |
| 1921 | L | Clayton Legion (NM) | 0 | Clayton HS (NM) | 67 | ? | |
| 1921 | L | Clayton Town Team (NM) | 0 | Clayton HS (NM) | 31 | ? | |
| 1921 | W | Clearfield HS (PA) | 27 | Altoona HS (PA) | 26 | ? | |
| 1921 | T | Clearfield HS (PA) | 6 | American Legion | 6 | ? | |
| 1921 | L | Clearfield HS (PA) | 7 | DuBois HS (PA) | 8 | ? | |
| 1921 | L | Clearfield HS (PA) | 0 | Huntingdon HS (PA) | 35 | ? | |
| 1921 | L | Clearfield HS (PA) | 14 | Mount Union HS (PA) | 21 | ? | |
| 1921 | L | Clearfield HS (PA) | 0 | Williamsport HS (PA) | 23 | ? | |
| 1921 | W | Clearfield HS (PA) | 12 | Windber HS (PA) | 6 | ? | |
| 1921 | L | Clearfield HS (PA) | 0 | Clarion (PA) | 12 | Clarion, PA | |
| 1921 | L | Clemson (SC) | 0 | Auburn (AL) | 56 | Auburn, AL | |
| 1921 | L | Clemson (SC) | 0 | Erskine (SC) | 13 | Clemson, SC | |
| 1921 | T | Clemson (SC) | 0 | Furman (SC) | 0 | Greenville, SC | |
| 1921 | L | Clemson (SC) | 0 | Georgia | 28 | Athens, GA | |
| 1921 | L | Clemson (SC) | 0 | South Carolina | 21 | Columbia, SC | |
| 1921 | L | Clemson (SC) | 0 | Centre (KY) | 14 | Danville, KY | |
| 1921 | L | Clemson (SC) | 7 | Georgia Tech | 48 | Atlanta, GA | |
| 1921 | W | Clemson (SC) | 34 | Presbyterian (SC) | 0 | Clemson, SC | |
| 1921 | T | Clemson (SC) | 7 | Citadel (SC) | 7 | Orangeburg, SC | |
| 1921 | L | Cleveland Central HS (OH) | 7 | Cleveland East HS (OH) | 35 | ? | |
| 1921 | L | Cleveland Central HS (OH) | 0 | Cleveland East Tech HS (OH) | 9 | ? | |
| 1921 | L | Cleveland Central HS (OH) | 0 | Cleveland South HS (OH) | 21 | ? | |
| 1921 | L | Cleveland Central HS (OH) | 0 | Cleveland University School (OH) | 27 | ? | |
| 1921 | L | Cleveland Central HS (OH) | 2 | Cleveland West HS (OH) | 12 | ? | |
| 1921 | L | Cleveland Central HS (OH) | 0 | Cleveland West Tech HS (OH) | 48 | ? | |
| 1921 | L | Cleveland Central HS (OH) | 0 | Glenville HS | 21 | ? | |
| 1921 | W | Cleveland Central HS (OH) | 12 | Longwood | 0 | ? | |
| 1921 | L | Cleveland Central HS (OH) | 0 | Saint Ignatius College (OH) | 21 | ? | |
| 1921 | W | Cleveland East HS (OH) | 35 | Cleveland Central HS (OH) | 7 | ? | |
| 1921 | L | Cleveland East HS (OH) | 7 | Cleveland East Tech HS (OH) | 46 | ? | |
| 1921 | W | Cleveland East HS (OH) | 13 | Cleveland University School (OH) | 7 | ? | |
| 1921 | W | Cleveland East HS (OH) | 7 | Cleveland West HS (OH) | 0 | ? | |
| 1921 | W | Cleveland East HS (OH) | 7 | East Cleveland Shaw HS (OH) | 0 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 9 | Cleveland Central HS (OH) | 0 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 46 | Cleveland East HS (OH) | 7 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 28 | Cleveland Lincoln HS (OH) | 0 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 40 | Cleveland South HS (OH) | 0 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 32 | Cleveland West HS (OH) | 7 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 37 | East Cleveland Shaw HS (OH) | 7 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 35 | Glenville HS | 0 | ? | |
| 1921 | W | Cleveland East Tech HS (OH) | 14 | Toledo Scott HS (OH) | 7 | ? | |
| 1921 | T | Cleveland Heights HS (OH) | 0 | Cleveland University School (OH) | 0 | ? | |
| 1921 | L | Cleveland Heights HS (OH) | 0 | East Cleveland Shaw HS (OH) | 21 | ? | |
| 1921 | L | Cleveland Heights HS (OH) | 6 | Lakewood HS (OH) | 39 | ? | |
| 1921 | W | Cleveland HS (MO) | 27 | Chaminade College HS (MO) | 0 | ? | |
| 1921 | L | Cleveland HS (MS) | 0 | Clarksdale HS (MS) | 41 | ? | |
| 1921 | L | Cleveland Lincoln HS (OH) | 0 | Cleveland East Tech HS (OH) | 28 | ? | |
| 1921 | L | Cleveland Lincoln HS (OH) | 12 | Cleveland West HS (OH) | 28 | ? | |
| 1921 | L | Cleveland Lincoln HS (OH) | 6 | Lakewood HS (OH) | 32 | ? | |
| 1921 | T | Cleveland Lincoln HS (OH) | 0 | Sandusky HS (OH) | 0 | ? | |
| 1921 | W | Cleveland South HS (OH) | 21 | Cleveland Central HS (OH) | 0 | ? | |
| 1921 | L | Cleveland South HS (OH) | 0 | Cleveland East Tech HS (OH) | 40 | ? | |
| 1921 | L | Cleveland South HS (OH) | 0 | Cleveland University School (OH) | 38 | ? | |
| 1921 | W | Cleveland University School (OH) | 17 | Cathedral Latin School (OH) | 0 | ? | |
| 1921 | W | Cleveland University School (OH) | 27 | Cleveland Central HS (OH) | 0 | ? | |
| 1921 | L | Cleveland University School (OH) | 7 | Cleveland East HS (OH) | 13 | ? | |
| 1921 | T | Cleveland University School (OH) | 0 | Cleveland Heights HS (OH) | 0 | ? | |
| 1921 | W | Cleveland University School (OH) | 38 | Cleveland South HS (OH) | 0 | ? | |
| 1921 | W | Cleveland University School (OH) | 27 | Cleveland West HS (OH) | 0 | ? | |
| 1921 | L | Cleveland University School (OH) | 0 | East Cleveland Shaw HS (OH) | 7 | ? | |
| 1921 | T | Cleveland University School (OH) | 6 | Lakewood HS (OH) | 6 | ? | |
| 1921 | W | Cleveland University School (OH) | 41 | Loyola | 0 | ? | |
| 1921 | W | Cleveland West HS (OH) | 12 | Cathedral Latin School (OH) | 0 | ? | |
| 1921 | W | Cleveland West HS (OH) | 12 | Cleveland Central HS (OH) | 2 | ? | |
| 1921 | L | Cleveland West HS (OH) | 0 | Cleveland East HS (OH) | 7 | ? | |
| 1921 | L | Cleveland West HS (OH) | 7 | Cleveland East Tech HS (OH) | 32 | ? | |
| 1921 | W | Cleveland West HS (OH) | 28 | Cleveland Lincoln HS (OH) | 12 | ? | |
| 1921 | L | Cleveland West HS (OH) | 0 | Cleveland University School (OH) | 27 | ? | |
| 1921 | L | Cleveland West HS (OH) | 6 | Cleveland West Tech HS (OH) | 7 | ? | |
| 1921 | W | Cleveland West HS (OH) | 42 | Loyola | 0 | ? | |
| 1921 | W | Cleveland West Tech HS (OH) | 48 | Cleveland Central HS (OH) | 0 | ? | |
| 1921 | W | Cleveland West Tech HS (OH) | 7 | Cleveland West HS (OH) | 6 | ? | |
| 1921 | W | Cleveland West Tech HS (OH) | 13 | Fitchburg HS (MA) | 12 | ? | |
| 1921 | W | Cliffside Park HS (NJ) | 34 | Englewood HS (NJ) | 0 | ? | |
| 1921 | W | Cliffside Park HS (NJ) | 21 | Evander Childs HS (NY) | 0 | ? | |
| 1921 | W | Cliffside Park HS (NJ) | 21 | Hackensack HS (NJ) | 7 | ? | |
| 1921 | L | Cliffside Park HS (NJ) | 10 | Passaic HS (NJ) | 23 | ? | |
| 1921 | W | Cliffside Park HS (NJ) | 73 | Pelham Manor HS (NY) | 0 | ? | |
| 1921 | W | Cliffside Park HS (NJ) | 12 | Ridgewood HS (NJ) | 7 | ? | |
| 1921 | L | Cliffside Park HS (NJ) | 7 | Rutherford HS (NJ) | 28 | ? | |
| 1921 | L | Cliffside Park HS (NJ) | 3 | Saint Peter's Prep (NJ) | 7 | ? | |
| 1921 | W | Cliffside Park HS (NJ) | 26 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | W | Cliffside Park HS (NJ) | 34 | Union Hill HS (NJ) | 0 | ? | |
| 1921 | W | Clifton HS (NJ) | 46 | Butler HS (NJ) | 0 | ? | |
| 1921 | W | Clifton HS (NJ) | 26 | Clifton HS Alumni (NJ) | 0 | ? | |
| 1921 | W | Clifton HS (NJ) | 21 | Hackensack HS (NJ) | 14 | ? | |
| 1921 | W | Clifton HS (NJ) | 28 | Hasbrouck Heights HS (NJ) | 0 | ? | |
| 1921 | W | Clifton HS (NJ) | 13 | Irvington HS (NJ) | 6 | ? | |
| 1921 | W | Clifton HS (NJ) | 26 | Park Ridge HS (NJ) | 19 | ? | |
| 1921 | L | Clifton HS (NJ) | 0 | Pingry School (NJ) | 1 | ? | |
| 1921 | W | Clifton HS (NJ) | 2 | Point Pleasant HS (NJ) | 0 | ? | |
| 1921 | W | Clifton HS (NJ) | 13 | Rutherford East HS (NJ) | 6 | ? | |
| 1921 | W | Clifton HS (NJ) | 32 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | L | Clifton HS Alumni (NJ) | 0 | Clifton HS (NJ) | 26 | ? | |
| 1921 | L | Clifton JC (TX) | 0 | John Tarleton College (TX) | 47 | ? | |
| 1921 | L | Clinton HS (IL) | 7 | Lincoln HS (IL) | 18 | ? | |
| 1921 | L | Clinton HS (IL) | 0 | Peoria Central HS (IL) | 66 | ? | |
| 1921 | L | Clinton HS (MA) | 0 | Fitchburg HS (MA) | 35 | ? | |
| 1921 | W | Clinton HS (MA) | 21 | Gardner HS (MA) | 0 | ? | |
| 1921 | W | Clinton HS (MA) | 26 | Gardner HS (MA) | 0 | ? | |
| 1921 | W | Clinton HS (MA) | 21 | Marlboro HS (VT) | 0 | ? | |
| 1921 | W | Clinton HS (MA) | 33 | Saint John's (MA) | 0 | ? | |
| 1921 | W | Clinton HS (MA) | 6 | Saint Marks School JV (MA) | 0 | ? | |
| 1921 | T | Clinton HS (MA) | 7 | Worcester Classical HS (MA) | 7 | ? | |
| 1921 | T | Clinton HS (MA) | 6 | Worcester Commerce HS (MA) | 6 | ? | |
| 1921 | L | Clinton HS (MA) | 8 | Worcester South HS (MA) | 13 | ? | |
| 1921 | W | Clinton HS (MI) | 10 | Tecumseh HS (MI) | 0 | ? | |
| 1921 | L | Clinton HS (MS) | 0 | Jackson HS (MS) | 19 | ? | |
| 1921 | W | Clinton HS (NJ) | 27 | Colonial | 0 | ? | |
| 1921 | T | Clinton HS (NJ) | 0 | Evander Childs HS (NY) | 0 | ? | |
| 1921 | L | Clinton HS (NJ) | 6 | Flemington HS (NJ) | 21 | ? | |
| 1921 | L | Clinton HS (NJ) | 0 | Flemington HS (NJ) | 12 | ? | |
| 1921 | W | Clinton HS (NJ) | 7 | Fordham Prep (NY) | 2 | ? | |
| 1921 | W | Clinton HS (NJ) | 13 | Freeport HS (NY) | 0 | ? | |
| 1921 | W | Clinton HS (NJ) | 34 | Horace Mann School (NY) | 0 | ? | |
| 1921 | L | Clinton HS (NJ) | 6 | Mamaroneck HS (NY) | 14 | ? | |
| 1921 | T | Clinton HS (NJ) | 7 | New Utrecht HS (NY) | 7 | ? | |
| 1921 | T | Clinton HS (NJ) | 0 | New York Freshmen (NY) | 0 | ? | |
| 1921 | L | Clinton HS (NJ) | 0 | Stuyvesant HS (NY) | 21 | ? | |
| 1921 | T | Clinton HS (NJ) | 0 | Toms River HS (NJ) | 0 | ? | |
| 1921 | L | Clinton HS (NJ) | 7 | Washington HS | 12 | ? | |
| 1921 | W | Clinton HS (NJ) | 20 | Washington HS | 13 | ? | |
| 1921 | L | Clinton HS (NY) | 0 | Herkimer HS (NY) | 33 | ? | |
| 1921 | L | Cloquet HS (MN) | 0 | Coleraine HS (MN) | 41 | ? | |
| 1921 | L | Cloquet HS (MN) | 6 | Duluth Denfeld HS (MN) | 42 | ? | |
| 1921 | L | Cloquet HS (MN) | 0 | Superior HS (WI) | 61 | ? | |
| 1921 | L | Clovis HS (NM) | 0 | Roswell HS (NM) | 25 | ? | |
| 1921 | L | Clovis HS (NM) | 0 | Roswell HS (NM) | 14 | ? | |
| 1921 | T | Clymer Independents (PA) | 0 | Curwensville HS (PA) | 0 | ? | |
| 1921 | L | Coaldale HS (PA) | 0 | Minersville HS (PA) | 35 | ? | |
| 1921 | W | Coatesville HS (PA) | 48 | Camden HS (NJ) | 7 | ? | |
| 1921 | L | Coatesville HS (PA) | 0 | Cheltenham HS (PA) | 6 | ? | |
| 1921 | W | Coatesville HS (PA) | 6 | Chester HS (PA) | 0 | ? | |
| 1921 | W | Coatesville HS (PA) | 7 | Lancaster HS (PA) | 3 | ? | |
| 1921 | T | Coatesville HS (PA) | 28 | Pennsylvania Institution for the Deaf | 28 | ? | |
| 1921 | W | Coatesville HS (PA) | 14 | Phoenixville HS (PA) | 0 | ? | |
| 1921 | W | Coatesville HS (PA) | 14 | Pottstown HS (PA) | 0 | ? | |
| 1921 | W | Coatesville HS (PA) | 6 | West Chester HS (PA) | 0 | ? | |
| 1921 | W | Coatesville HS (PA) | 7 | Williamson Trade School JV (PA) | 0 | ? | |
| 1921 | W | Coatesville HS (PA) | 14 | York HS (PA) | 0 | ? | |
| 1921 | L | Coburn Classical Institute (ME) | 0 | Colby (ME) | 32 | Waterville, ME | |
| 1921 | W | Coe (IA) | 28 | Cornell College (IA) | 7 | Cedar Rapids, IA | |
| 1921 | W | Coe (IA) | 28 | Dubuque (IA) | 7 | Cedar Rapids, IA | |
| 1921 | W | Coe (IA) | 10 | Grinnell (IA) | 0 | Grinnell, IA | |
| 1921 | W | Coe (IA) | 13 | Northern Iowa | 7 | Cedar Rapids, IA | |
| 1921 | W | Coe (IA) | 70 | Simpson (IA) | 0 | Indianola, IA | |
| 1921 | L | Coe (IA) | 3 | Iowa St. | 28 | Ames, IA | |
| 1921 | W | Coe (IA) | 38 | Knox (IL) | 0 | Cedar Rapids, IA | |
| 1921 | L | Coffeyville HS (KS) | 0 | Independence HS (KS) | 35 | ? | |
| 1921 | L | Cogswell Polytechnical College (CA) | 0 | San Francisco HS of Commerce (CA) | 33 | ? | |
| 1921 | L | Cogswell Polytechnical College (CA) | 0 | San Francisco Lick Wilmerding HS (CA) | 28 | ? | |
| 1921 | L | Col. Academy | 0 | London HS (OH) | 24 | ? | |
| 1921 | T | Colby (ME) | 7 | Bates (ME) | 7 | Waterville, ME | |
| 1921 | L | Colby (ME) | 6 | Bowdoin (ME) | 18 | Brunswick, ME | |
| 1921 | W | Colby (ME) | 32 | Coburn Classical Institute (ME) | 0 | Waterville, ME | |
| 1921 | W | Colby (ME) | 3 | Maine | 0 | Waterville, ME | |
| 1921 | L | Colby (ME) | 7 | Brown (RI) | 12 | Providence, RI | |
| 1921 | L | Colby (ME) | 7 | New Hampshire | 24 | Waterville, ME | |
| 1921 | L | Colby (ME) | 6 | Springfield (MA) | 13 | Springfield, MA | |
| 1921 | L | Colby (ME) | 0 | Holy Cross (MA) | 14 | Worcester, MA | |
| 1921 | W | Colby Academy (NH) | 21 | Claremont Stevens HS (NH) | 0 | ? | |
| 1921 | L | Colby Academy (NH) | 0 | Cushing Academy (MA) | 14 | ? | |
| 1921 | W | Colby Academy (NH) | 28 | Kimball Union Academy (NH) | 0 | ? | |
| 1921 | W | Colby Academy (NH) | 45 | Montpelier Seminary (VT) | 0 | ? | |
| 1921 | W | Colby Academy (NH) | 21 | New Hampshire Institute | 0 | ? | |
| 1921 | W | Colby Academy (NH) | 6 | Tilton Seminary (NH) | 0 | ? | |
| 1921 | W | Coldwater HS (MI) | 12 | Albion HS (MI) | 7 | ? | |
| 1921 | L | Coldwater HS (MI) | 0 | Marshall HS (MI) | 33 | ? | |
| 1921 | L | Coleraine HS (MN) | 0 | Alexandria HS (MN) | 41 | ? | |
| 1921 | W | Coleraine HS (MN) | 13 | Aurora HS (MN) | 0 | ? | |
| 1921 | W | Coleraine HS (MN) | 41 | Cloquet HS (MN) | 0 | ? | |
| 1921 | W | Coleraine HS (MN) | 6 | Duluth Denfeld HS (MN) | 0 | ? | |
| 1921 | W | Coleraine HS (MN) | 41 | Grand Rapids HS (MN) | 0 | ? | |
| 1921 | W | Coleraine HS (MN) | 54 | Grand Rapids HS (MN) | 0 | ? | |
| 1921 | W | Coleraine HS (MN) | 13 | Hibbing HS (MN) | 0 | ? | |
| 1921 | W | Coleraine HS (MN) | 82 | Mountain Iron HS (MN) | 0 | ? | |
| 1921 | L | Colgate (NY) | 0 | Brown (RI) | 7 | Providence, RI | |
| 1921 | W | Colgate (NY) | 21 | Columbia (NY) | 14 | New York, NY | |
| 1921 | L | Colgate (NY) | 7 | Cornell (NY) | 31 | Ithaca, NY | |
| 1921 | T | Colgate (NY) | 7 | New York (NY) | 7 | Johnson City, NY | |
| 1921 | T | Colgate (NY) | 7 | Saint Bonaventure (NY) | 7 | Hamilton, NY | |
| 1921 | W | Colgate (NY) | 21 | Susquehanna (PA) | 6 | Hamilton, NY | |
| 1921 | W | Colgate (NY) | 14 | Allegheny (PA) | 0 | Hamilton, NY | |
| 1921 | W | Colgate (NY) | 41 | Rochester (NY) | 0 | Hamilton, NY | |
| 1921 | L | Colgate (NY) | 0 | Princeton (NJ) | 19 | Princeton, NJ | |
| 1921 | L | Colgate (NY) | 0 | Syracuse (NY) | 14 | Syracuse, NY | |
| 1921 | L | Colgate Freshmen (NY) | 6 | Cazenovia Seminary (NY) | 23 | Cazenovia, NY | |
| 1921 | L | Colgate Freshmen (NY) | 0 | Saint John's Military Academy (NY) | 14 | ? | |
| 1921 | L | College AEF Veterans | 0 | Wheaton (IL) | 18 | Wheaton, IL | |
| 1921 | L | College of Charleston (SC) | 0 | Erskine (SC) | 74 | Due West, SC | |
| 1921 | L | College of Charleston (SC) | 0 | Newberry (SC) | 41 | Newberry, SC | |
| 1921 | L | College of Charleston (SC) | 0 | Rollins (FL) | 41 | ? | |
| 1921 | W | College of Emporia (KS) | 28 | Ottawa (KS) | 0 | Emporia, KS | |
| 1921 | L | College of Emporia (KS) | 10 | Pittsburg St. (KS) | 14 | Emporia, KS | |
| 1921 | W | College of Emporia (KS) | 12 | Southwestern (KS) | 0 | Winfield, KS | |
| 1921 | L | College of Emporia (KS) | 3 | Kansas St. | 7 | Manhattan, KS | |
| 1921 | T | College of Emporia (KS) | 7 | Oklahoma St. | 7 | Stillwater, OK | |
| 1921 | W | College of Emporia (KS) | 3 | Baker (KS) | 0 | Baldwin City, KS | |
| 1921 | W | College of Emporia (KS) | 6 | Washburn (KS) | 3 | Emporia, KS | |
| 1921 | W | College of Idaho | 56 | Gooding (ID) | 0 | ? | |
| 1921 | L | College of Idaho | 7 | Idaho St. | 13 | Pocatello, ID | |
| 1921 | W | College of Idaho | 28 | Montana Wesleyan | 7 | Caldwell, ID | |
| 1921 | L | College of Idaho | 14 | Whitman (WA) | 17 | Walla Walla, WA | |
| 1921 | L | College of Idaho | 0 | Gonzaga (WA) | 36 | Caldwell, ID | |
| 1921 | L | College of Idaho | 0 | Utah St. | 20 | Logan, UT | |
| 1921 | L | College of Marshall (TX) | 0 | Centenary (LA) | 30 | ? | |
| 1921 | L | College of Marshall (TX) | 2 | Dallas (TX) | 14 | Dallas, TX | |
| 1921 | W | College of Marshall (TX) | 14 | Lon Morris (TX) | 13 | ? | |
| 1921 | W | College of Marshall (TX) | 13 | Marshall All-Stars (TX) | 0 | ? | |
| 1921 | L | College of Marshall (TX) | 0 | Rusk Baptist College (TX) | 6 | ? | Rusk Baptist College won - score unknown |
| 1921 | W | College of Marshall (TX) | 7 | Southern Methodist Freshmen (TX) | 0 | ? | |
| 1921 | T | College of Marshall (TX) | 0 | Texas A&M-Commerce | 0 | Commerce, TX | |
| 1921 | L | College of Marshall (TX) | 0 | Texas Freshmen | 6 | ? | Texas Freshmen won - score unknown |
| 1921 | T | Collingswood HS (NJ) | 6 | Atlantic City HS (NJ) | 6 | ? | |
| 1921 | L | Collingswood HS (NJ) | 7 | Germantown HS (PA) | 9 | ? | |
| 1921 | W | Collingswood HS (NJ) | 14 | Haddon Heights HS (NJ) | 0 | ? | |
| 1921 | W | Collingswood HS (NJ) | 14 | Hammonton HS (NJ) | 7 | ? | |
| 1921 | W | Collingswood HS (NJ) | 35 | Millville HS (NJ) | 0 | ? | |
| 1921 | W | Collingswood HS (NJ) | 14 | Moorestown HS (NJ) | 0 | ? | |
| 1921 | W | Collingswood HS (NJ) | 23 | Penns Grove HS (NJ) | 7 | ? | |
| 1921 | T | Collingswood HS (NJ) | 7 | Woodbury HS (NJ) | 7 | ? | |
| 1921 | W | Collinsville HS (OK) | 27 | Bigheart HS | 0 | ? | |
| 1921 | L | Collinsville HS (OK) | 0 | Broken Arrow HS (OK) | 39 | ? | |
| 1921 | L | Collinsville HS (OK) | 0 | Delaware HS (OK) | 6 | ? | |
| 1921 | L | Collinsville HS (OK) | 0 | Glenpool HS (OK) | 52 | ? | |
| 1921 | W | Collinsville HS (OK) | 21 | Owasso HS (OK) | 6 | ? | |
| 1921 | L | Collinsville HS (OK) | 0 | Ramona HS (OK) | 54 | ? | |
| 1921 | L | Collinsville HS (OK) | 6 | Sand Springs HS (OK) | 35 | ? | |
| 1921 | L | Collinsville HS (OK) | 0 | Skiatook HS (OK) | 20 | ? | |
| 1921 | W | Collinsville HS (OK) | 3 | Tulsa Senior HS (OK) | 0 | ? | |
| 1921 | L | Colonial | 0 | Clinton HS (NJ) | 27 | ? | |
| 1921 | L | Colorado | 0 | Chicago (IL) | 35 | Chicago, IL | |
| 1921 | W | Colorado | 10 | Colorado School of Mines | 7 | Boulder, CO | |
| 1921 | W | Colorado | 10 | Colorado St. | 0 | Fort Collins, CO | |
| 1921 | W | Colorado | 10 | Denver (CO) | 7 | Boulder, CO | |
| 1921 | W | Colorado | 35 | Colorado College | 14 | Boulder, CO | |
| 1921 | T | Colorado | 0 | Utah | 0 | Salt Lake City, UT | |
| 1921 | L | Colorado College | 0 | Colorado St. | 24 | Colorado Springs, CO | |
| 1921 | W | Colorado College | 28 | Denver (CO) | 21 | Colorado Springs, CO | |
| 1921 | W | Colorado College | 7 | New Mexico | 0 | Colorado Springs, CO | |
| 1921 | L | Colorado College | 3 | Utah | 14 | Colorado Springs, CO | |
| 1921 | W | Colorado College | 37 | Grand Island College (NE) | 7 | Colorado Springs, CO | |
| 1921 | L | Colorado College | 14 | Colorado | 35 | Boulder, CO | |
| 1921 | W | Colorado College | 10 | Wyoming | 0 | Laramie, WY | |
| 1921 | L | Colorado College | 0 | Colorado School of Mines | 7 | Denver, CO | |
| 1921 | W | Colorado College Freshmen | 14 | Northern Colorado | 0 | Colorado Springs, CO | |
| 1921 | W | Colorado College Freshmen | 7 | Regis (CO) | 0 | ? | |
| 1921 | L | Colorado Freshmen | 0 | Regis (CO) | 14 | ? | |
| 1921 | L | Colorado School of Mines | 7 | Colorado | 10 | Boulder, CO | |
| 1921 | L | Colorado School of Mines | 0 | Colorado St. | 24 | Fort Collins, CO | |
| 1921 | L | Colorado School of Mines | 7 | Wyoming | 14 | Laramie, WY | |
| 1921 | L | Colorado School of Mines | 7 | Utah St. | 23 | Pueblo, CO | |
| 1921 | L | Colorado School of Mines | 7 | Denver (CO) | 13 | Denver, CO | |
| 1921 | W | Colorado School of Mines | 7 | Colorado College | 0 | Denver, CO | |
| 1921 | L | Colorado School of Mines Freshmen | 0 | Northern Colorado | 3 | Greeley, CO | |
| 1921 | T | Colorado School of Mines Freshmen | 7 | Northern Colorado | 7 | Greeley, CO | |
| 1921 | L | Colorado School of Mines Freshmen | 7 | Regis (CO) | 27 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 45 | Cheyenne HS (WY) | 0 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 21 | Denver East HS (CO) | 0 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 72 | Denver Manual HS (CO) | 0 | ? | |
| 1921 | T | Colorado Springs HS (CO) | 0 | Denver West HS (CO) | 0 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 10 | Lamar HS (CO) | 0 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 16 | Longmont HS (CO) | 0 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 31 | Pueblo Centennial HS (CO) | 0 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 18 | Pueblo Centennial HS (CO) | 6 | ? | |
| 1921 | W | Colorado Springs HS (CO) | 33 | Pueblo Central HS (CO) | 0 | ? | |
| 1921 | L | Colorado Springs HS (CO) | 0 | Salt Lake City East Side HS (UT) | 28 | ? | |
| 1921 | L | Colorado St. | 0 | Colorado | 10 | Fort Collins, CO | |
| 1921 | W | Colorado St. | 24 | Colorado College | 0 | Colorado Springs, CO | |
| 1921 | W | Colorado St. | 24 | Colorado School of Mines | 0 | Fort Collins, CO | |
| 1921 | L | Colorado St. | 14 | Denver (CO) | 21 | Fort Collins, CO | |
| 1921 | L | Colorado St. | 7 | Nebraska | 70 | Lincoln, NE | |
| 1921 | T | Colorado St. | 7 | Wyoming | 7 | Fort Collins, CO | |
| 1921 | L | Colorado St. B Team | 6 | Laramie HS (WY) | 36 | ? | Colorado St. JV in question |
| 1921 | W | Colorado St. Freshmen | 21 | Northern Colorado | 10 | Greeley, CO | |
| 1921 | W | Colorado St. Freshmen | 21 | Regis (CO) | 7 | ? | |
| 1921 | L | Columbia (NY) | 14 | Colgate (NY) | 21 | New York, NY | |
| 1921 | L | Columbia (NY) | 7 | Dartmouth (NH) | 31 | Hanover, NH | |
| 1921 | W | Columbia (NY) | 19 | New York (NY) | 0 | New York, NY | |
| 1921 | L | Columbia (NY) | 0 | Williams (MA) | 20 | Williamstown, MA | |
| 1921 | L | Columbia (NY) | 7 | Amherst (MA) | 9 | New York, NY | |
| 1921 | L | Columbia (NY) | 7 | Cornell (NY) | 41 | New York, NY | |
| 1921 | W | Columbia (NY) | 14 | Wesleyan (CT) | 3 | Middletown, CT | |
| 1921 | L | Columbia (NY) | 21 | Ohio | 23 | New York, NY | |
| 1921 | W | Columbia Freshmen (NY) | 21 | Hotchkiss Academy (CT) | 0 | ? | |
| 1921 | W | Columbia Freshmen (NY) | 14 | New York Military Academy | 0 | ? | |
| 1921 | L | Columbia HS (SC) | 14 | Charleston HS (SC) | 28 | ? | |
| 1921 | L | Columbia HS (TN) | 6 | Memphis Central HS (TN) | 41 | ? | |
| 1921 | L | Columbia HS (TN) | 0 | Nashville Hume-Fogg HS (TN) | 52 | ? | |
| 1921 | W | Columbia Prep | 14 | Yonkers HS (NY) | 6 | ? | |
| 1921 | W | Columbus (SD) | 76 | Augustana (SD) | 0 | ? | |
| 1921 | W | Columbus (SD) | 21 | Northern St. (SD) | 3 | Sioux Falls, SD | |
| 1921 | W | Columbus (SD) | 14 | Saint Mary's (MN) | 0 | Sioux Falls, SD | |
| 1921 | W | Columbus (SD) | 30 | Si Tanka (SD) | 0 | ? | |
| 1921 | L | Columbus (SD) | 6 | South Dakota Tech | 14 | ? | |
| 1921 | L | Columbus (SD) | 0 | Trinity (IA) | 1 | ? | Columbus Forfeits |
| 1921 | W | Columbus (SD) | 21 | Buena Vista (IA) | 7 | Storm Lake, IA | |
| 1921 | W | Columbus East HS (OH) | 7 | Chillicothe HS (OH) | 0 | ? | |
| 1921 | L | Columbus East HS (OH) | 0 | Columbus South HS (OH) | 7 | ? | |
| 1921 | L | Columbus East HS (OH) | 0 | Martins Ferry HS (OH) | 25 | ? | |
| 1921 | L | Columbus East HS (OH) | 0 | Toledo Scott HS (OH) | 45 | ? | |
| 1921 | L | Columbus HS (KS) | 3 | Joplin HS (MO) | 20 | ? | |
| 1921 | L | Columbus HS (MT) | 0 | Park County HS (MT) | 59 | ? | |
| 1921 | L | Columbus HS (NE) | 13 | North Platte HS (NE) | 16 | ? | |
| 1921 | L | Columbus HS of Commerce (OH) | 0 | Dewitt Clinton HS (NY) | 7 | ? | |
| 1921 | L | Columbus HS of Commerce (OH) | 6 | London HS (OH) | 26 | ? | |
| 1921 | T | Columbus North HS (OH) | 0 | Columbus South HS (OH) | 0 | ? | |
| 1921 | L | Columbus North HS (OH) | 0 | Dayton Steele HS (OH) | 31 | ? | |
| 1921 | W | Columbus North HS (OH) | 14 | London HS (OH) | 0 | ? | |
| 1921 | L | Columbus South HS (OH) | 7 | Aquinas College (MI) | 13 | ? | |
| 1921 | W | Columbus South HS (OH) | 7 | Columbus East HS (OH) | 0 | ? | |
| 1921 | T | Columbus South HS (OH) | 0 | Columbus North HS (OH) | 0 | ? | |
| 1921 | W | Columbus South HS (OH) | 28 | Columbus Trades School (OH) | 0 | ? | |
| 1921 | W | Columbus South HS (OH) | 14 | Columbus West HS (OH) | 0 | ? | |
| 1921 | L | Columbus South HS (OH) | 0 | Dayton Steele HS (OH) | 112 | ? | |
| 1921 | W | Columbus South HS (OH) | 7 | Delaware HS (OH) | 0 | ? | |
| 1921 | L | Columbus South HS (OH) | 0 | Lancaster HS (OH) | 6 | ? | |
| 1921 | L | Columbus South HS (OH) | 0 | Newark HS (OH) | 14 | ? | |
| 1921 | L | Columbus Trades School (OH) | 0 | Columbus South HS (OH) | 28 | ? | |
| 1921 | L | Columbus Trades School (OH) | 12 | London HS (OH) | 33 | ? | |
| 1921 | L | Columbus West HS (OH) | 0 | Columbus South HS (OH) | 14 | ? | |
| 1921 | L | Columbus West HS (OH) | 0 | Springfield HS (OH) | 7 | ? | |
| 1921 | L | Commercial HS | 0 | Hopkins Grammar School (CT) | 22 | ? | |
| 1921 | L | Concord (WV) | 0 | Hinton HS (WV) | 7 | ? | |
| 1921 | L | Concord (WV) | 0 | West Virginia Tech | 40 | ? | |
| 1921 | L | Concord HS (MA) | 12 | Browne & Nichols School (MA) | 14 | ? | |
| 1921 | L | Concord HS (MA) | 0 | Framingham HS (MA) | 42 | ? | |
| 1921 | L | Concord HS (MA) | 0 | Medford HS (MA) | 3 | ? | |
| 1921 | L | Concord HS (MA) | 6 | Natick HS (MA) | 13 | ? | |
| 1921 | L | Concord HS (NH) | 0 | Manchester HS (NH) | 14 | ? | |
| 1921 | L | Concord HS (NH) | 0 | Tilton Seminary (NH) | 6 | ? | |
| 1921 | W | Concordia Prep School (NY) | 37 | Brooklyn Evening HS (NY) | 14 | ? | |
| 1921 | W | Concordia Prep School (NY) | 48 | Cooper Union (NY) | 0 | Brooklyn, NY | |
| 1921 | W | Concordia Prep School (NY) | 95 | Hamilton Institute (NY) | 0 | ? | |
| 1921 | L | Concordia Prep School (NY) | 0 | Irving School (NY) | 35 | ? | |
| 1921 | L | Concordia Prep School (NY) | 9 | Mount Vernon HS (NY) | 14 | ? | |
| 1921 | T | Concordia Prep School (NY) | 0 | New York HS of Commerce (NY) | 0 | ? | |
| 1921 | W | Concordia Prep School (NY) | 32 | New York Morris HS (NY) | 0 | ? | |
| 1921 | W | Concordia Prep School (NY) | 21 | Upsala (NJ) | 7 | ? | |
| 1921 | T | Concordia Prep School JV (NY) | 12 | Bronxville HS (NY) | 12 | ? | |
| 1921 | T | Concordia-Moorhead (MN) | 7 | Fargo College (ND) | 7 | Fargo, ND | |
| 1921 | W | Concordia-Moorhead (MN) | 28 | Jamestown (ND) | 0 | Moorhead, MN | |
| 1921 | W | Concordia-Moorhead (MN) | 42 | North Dakota Science | 7 | Moorhead, MN | |
| 1921 | L | Concordia-Moorhead (MN) | 0 | Carleton (MN) | 74 | Moorhead, MN | |
| 1921 | L | Concordia-Moorhead (MN) | 6 | Moorhead St. (MN) | 18 | Moorhead, MN | |
| 1921 | L | Concordia-Moorhead (MN) | 0 | Saint Olaf (MN) | 97 | Northfield, MN | |
| 1921 | T | Connecticut | 7 | Massachusetts-Lowell | 7 | Lowell, MA | |
| 1921 | L | Connecticut | 21 | Rhode Island | 27 | Kingston, RI | |
| 1921 | W | Connecticut | 21 | Saint Stephen's College (NY) | 0 | Storrs, CT | |
| 1921 | W | Connecticut | 27 | Worcester Tech (MA) | 14 | Storrs, CT | |
| 1921 | L | Connecticut | 0 | Massachusetts | 13 | Storrs, CT | |
| 1921 | W | Connecticut | 39 | Saint Lawrence (NY) | 14 | Storrs, CT | |
| 1921 | T | Connecticut | 0 | Trinity (CT) | 0 | Storrs, CT | |
| 1921 | T | Connecticut | 0 | Widener (PA) | 0 | Chester, PA | |
| 1921 | L | Connecticut JV | 0 | New Britain HS (CT) | 6 | ? | |
| 1921 | W | Connecticut JV | 13 | New London Vocational HS (CT) | 0 | ? | Connecticut JV in question |
| 1921 | L | Connellsville HS (PA) | 0 | Johnstown HS (PA) | 42 | ? | |
| 1921 | L | Connellsville HS (PA) | 0 | Washington HS (PA) | 45 | ? | |
| 1921 | L | Conway HS (AR) | 0 | Pine Bluff HS (AR) | 54 | ? | |
| 1921 | L | Conway HS (AR) | 0 | Russellville HS (AR) | 21 | ? | |
| 1921 | L | Conway HS (AR) | 0 | Russellville HS (AR) | 35 | ? | |
| 1921 | L | Conway Springs HS (KS) | 6 | Kingman HS (KS) | 54 | ? | |
| 1921 | W | Cook Academy (NY) | 21 | Athens HS (NY) | 3 | ? | |
| 1921 | L | Cook Academy (NY) | 0 | Cazenovia Seminary (NY) | 41 | ? | |
| 1921 | L | Cook Academy (NY) | 7 | Corning Free Academy (NY) | 12 | ? | |
| 1921 | L | Cook Academy (NY) | 6 | Haverling | 13 | ? | |
| 1921 | W | Cook Academy (NY) | 19 | Saint Francis de Sales | 7 | ? | |
| 1921 | L | Cook Academy (NY) | 6 | Sayre HS (PA) | 14 | ? | |
| 1921 | W | Cook Academy (NY) | 51 | Starkey Seminary (NY) | 13 | ? | |
| 1921 | W | Cook Academy (NY) | 43 | Starkey Seminary (NY) | 0 | ? | |
| 1921 | L | Cook Academy (NY) | 6 | Waverly HS (NY) | 7 | ? | |
| 1921 | W | Cooke Academy | 33 | Athens HS (PA) | 20 | ? | |
| 1921 | L | Cooper Union (NY) | 0 | Brooklyn Evening HS (NY) | 42 | Brooklyn, NY | P.S.A.L. Field |
| 1921 | L | Cooper Union (NY) | 0 | Concordia Prep School (NY) | 48 | Brooklyn, NY | |
| 1921 | L | Cooper Union (NY) | 0 | Saint John's Prep (NY) | 7 | Brooklyn, NY | |
| 1921 | L | Cooper Union (NY) | 0 | SUNY-Farmingdale (NY) | 20 | Farmingdale, NY | |
| 1921 | L | Coraopolis HS (PA) | 0 | Monaca HS (PA) | 53 | ? | |
| 1921 | L | Coraopolis HS (PA) | 0 | Sewickley HS (PA) | 41 | ? | |
| 1921 | W | Cornell (NY) | 31 | Colgate (NY) | 7 | Ithaca, NY | |
| 1921 | W | Cornell (NY) | 59 | Dartmouth (NH) | 7 | Ithaca, NY | |
| 1921 | W | Cornell (NY) | 41 | Pennsylvania | 0 | Philadelphia, PA | |
| 1921 | W | Cornell (NY) | 110 | Western Reserve (OH) | 0 | Ithaca, NY | |
| 1921 | W | Cornell (NY) | 41 | Saint Bonaventure (NY) | 0 | Ithaca, NY | |
| 1921 | W | Cornell (NY) | 41 | Columbia (NY) | 7 | New York, NY | |
| 1921 | W | Cornell (NY) | 55 | Rochester (NY) | 0 | Ithaca, NY | |
| 1921 | W | Cornell (NY) | 14 | Springfield (MA) | 0 | Ithaca, NY | |
| 1921 | L | Cornell College (IA) | 7 | Coe (IA) | 28 | Cedar Rapids, IA | |
| 1921 | L | Cornell College (IA) | 0 | Drake (IA) | 41 | Des Moines, IA | |
| 1921 | T | Cornell College (IA) | 0 | Dubuque (IA) | 0 | Mount Vernon, IA | |
| 1921 | W | Cornell College (IA) | 27 | Iowa Wesleyan | 7 | Mount Pleasant, IA | |
| 1921 | W | Cornell College (IA) | 20 | Upper Iowa | 6 | Mount Vernon, IA | |
| 1921 | W | Cornell College (IA) | 56 | Simpson (IA) | 0 | Mount Vernon, IA | |
| 1921 | L | Cornell College (IA) | 2 | Hamline (MN) | 13 | Mount Vernon, IA | |
| 1921 | L | Cornell College (IA) | 6 | Grinnell (IA) | 13 | Grinnell, IA | |
| 1921 | L | Cornell Freshmen (NY) | 0 | Kiski Academy (PA) | 19 | ? | |
| 1921 | T | Cornell Freshmen (NY) | 0 | Wyoming Seminary (PA) | 0 | ? | |
| 1921 | L | Corning Free Academy (NY) | 0 | Athens HS (PA) | 13 | ? | |
| 1921 | L | Corning Free Academy (NY) | 0 | Binghamton Central HS (NY) | 27 | ? | |
| 1921 | W | Corning Free Academy (NY) | 12 | Cook Academy (NY) | 7 | ? | |
| 1921 | L | Coronado HS (CA) | 12 | Harvard Military School (CA) | 33 | ? | |
| 1921 | L | Cortland HS (NY) | 0 | Endicott Union HS (NY) | 42 | ? | |
| 1921 | W | Cortland HS (NY) | 7 | Sherrill HS (NY) | 0 | ? | |
| 1921 | L | Coshocton HS (OH) | 0 | Martins Ferry HS (OH) | 41 | ? | |
| 1921 | W | Cotner (NE) | 10 | Doane (NE) | 7 | Bethany, NE | |
| 1921 | T | Cotner (NE) | 0 | Grand Island College (NE) | 0 | ? | |
| 1921 | L | Cotner (NE) | 0 | Nebraska-Kearney | 3 | Bethany, NE | |
| 1921 | L | Cotner (NE) | 3 | Peru St. (NE) | 28 | ? | |
| 1921 | W | Cotner (NE) | 7 | York (NE) | 6 | ? | |
| 1921 | T | Cotner (NE) | 0 | Nebraska-Omaha | 0 | Omaha, NE | |
| 1921 | L | Cotner (NE) | 0 | Hastings (NE) | 17 | Hastings, NE | |
| 1921 | Cotner (NE) | 10 | Cotner Alumni (NE) | 0 | |||
| 1921 | L | Cotner Alumni (NE) | 0 | Cotner (NE) | 10 | Bethany, NE | |
| 1921 | Cotner Alumni (NE) | 0 | Cotner (NE) | 10 | |||
| 1921 | W | Country Day School (MA) | 25 | Browne & Nichols School (MA) | 0 | ? | |
| 1921 | W | Country Day School (MA) | 7 | Roxbury Latin School (MA) | 0 | ? | |
| 1921 | W | Country Day School (MA) | 27 | Thayer Academy (MA) | 0 | ? | |
| 1921 | L | Country Day School (MO) | 0 | McKendree (IL) | 94 | ? | |
| 1921 | L | Country Day School (NS) | 0 | Country Day School (WI) | 38 | ? | |
| 1921 | W | Country Day School (WI) | 38 | Country Day School (NS) | 0 | ? | |
| 1921 | W | Country Day School (WI) | 35 | Lincoln HS | 0 | ? | |
| 1921 | W | Country Day School (WI) | 7 | Saint John's HS | 0 | ? | |
| 1921 | L | Country Day School (WI) | 6 | Wawatosa HS | 71 | ? | |
| 1921 | L | Country Day School (WI) | 0 | Wayland Academy (WI) | 12 | ? | |
| 1921 | L | Coupeville HS (WA) | 13 | Granite Falls HS (WA) | 33 | ? | |
| 1921 | L | Covina HS (CA) | 7 | South Pasadena HS (CA) | 13 | ? | |
| 1921 | W | Covington HS | 20 | Hinton HS (WV) | 0 | ? | |
| 1921 | L | Cozad HS (NE) | 0 | Nebraska School of Agriculture | 40 | ? | |
| 1921 | L | Cozad HS (NE) | 0 | North Platte HS (NE) | 176 | ? | |
| 1921 | L | Crafton HS (PA) | 7 | Martins Ferry HS (OH) | 40 | ? | |
| 1921 | L | Crane JC (IL) | 0 | Culver Military Academy (IN) | 51 | ? | |
| 1921 | L | Crane JC (IL) | 0 | Saint Viator (IL) | 67 | Bourbonnais, IL | |
| 1921 | L | Crane JC (IL) | 0 | Wheaton (IL) | 5 | Chicago, IL | |
| 1921 | L | Crane JC (IL) | 0 | North Central (IL) | 18 | Naperville, IL | |
| 1921 | L | Cranford | 0 | Alliance HS (NE) | 42 | ? | |
| 1921 | L | Cranford HS (NJ) | 0 | Pingry School (NJ) | 62 | ? | |
| 1921 | L | Cranford HS (NJ) | 0 | Roselle HS (NJ) | 26 | ? | |
| 1921 | L | Cranford HS (NJ) | 0 | Roselle Park HS (NJ) | 65 | ? | |
| 1921 | L | Cranford HS (NJ) | 0 | Summit HS (NJ) | 27 | ? | |
| 1921 | L | Cranford HS (NJ) | 0 | Westfield HS (NJ) | 32 | ? | |
| 1921 | L | Crawford HS (NE) | 33 | Edgemont HS (SD) | 35 | ? | |
| 1921 | W | Creighton (NE) | 14 | Kansas St. | 7 | Omaha, NE | |
| 1921 | W | Creighton (NE) | 3 | Marquette (WI) | 0 | Omaha, NE | |
| 1921 | W | Creighton (NE) | 19 | South Dakota | 0 | Omaha, NE | |
| 1921 | L | Creighton (NE) | 0 | South Dakota St. | 7 | Omaha, NE | |
| 1921 | W | Creighton (NE) | 14 | Xavier (OH) | 7 | Cincinnati, OH | |
| 1921 | W | Creighton (NE) | 21 | Dakota Wesleyan (SD) | 0 | Omaha, NE | |
| 1921 | W | Creighton (NE) | 21 | Saint Louis (MO) | 0 | Omaha, NE | |
| 1921 | W | Creighton (NE) | 28 | Des Moines (IA) | 0 | Des Moines, IA | |
| 1921 | W | Creighton (NE) | 26 | Oklahoma St. | 13 | Omaha, NE | |
| 1921 | L | Creighton HS (NE) | 0 | North Platte HS (NE) | 40 | ? | |
| 1921 | W | Cresco HS (IA) | 32 | Lanesboro HS (MN) | 21 | ? | |
| 1921 | L | Cresco HS (IA) | 0 | Osage HS (IA) | 38 | ? | |
| 1921 | W | Crookston HS (MN) | 22 | Ada HS (MN) | 20 | ? | |
| 1921 | L | Crookston HS (MN) | 6 | East Grand Forks HS (MN) | 12 | ? | |
| 1921 | W | Crookston HS (MN) | 53 | Fosston HS (MN) | 6 | ? | |
| 1921 | W | Crookston HS (MN) | 21 | Northwest School of Agriculture (MN) | 0 | ? | |
| 1921 | L | Crookston HS (MN) | 0 | Stephen HS (MN) | 21 | ? | |
| 1921 | W | Crookston HS (MN) | 27 | Thief River Falls HS (MN) | 0 | ? | |
| 1921 | W | Crookston HS (MN) | 41 | Warren HS (MN) | 0 | ? | |
| 1921 | T | Crosby HS | 0 | Bridgeport HS (CT) | 0 | ? | |
| 1921 | T | Crosby HS (CT) | 0 | Bridgeport HS (CT) | 0 | ? | |
| 1921 | W | Crosby HS (CT) | 14 | Chicopee HS (MA) | 0 | ? | |
| 1921 | W | Crosby HS (CT) | 28 | Derby HS (CT) | 0 | ? | |
| 1921 | L | Crosby HS (CT) | 12 | Hopkins Grammar School (CT) | 19 | ? | |
| 1921 | L | Crosby HS (CT) | 12 | Hopkins Prep (CT) | 19 | ? | |
| 1921 | L | Crosby HS (CT) | 0 | Naugatuck HS (CT) | 7 | ? | |
| 1921 | W | Crosby HS (CT) | 35 | New London HS (CT) | 0 | ? | |
| 1921 | W | Crosby HS (CT) | 49 | South Norwalk HS (CT) | 0 | ? | |
| 1921 | T | Crosby HS (CT) | 0 | Torrington HS (CT) | 0 | ? | |
| 1921 | L | Crosby HS (MN) | 0 | Little Falls HS (MN) | 47 | ? | |
| 1921 | L | Crosby HS (ND) | 0 | Williston HS (ND) | 165 | ? | |
| 1921 | W | Culver Military Academy (IN) | 51 | Crane JC (IL) | 0 | ? | |
| 1921 | L | Culver Military Academy (IN) | 3 | Kemper Military School (MO) | 7 | ? | |
| 1921 | L | Culver Military Academy (IN) | 7 | Lake Forest Academy (IL) | 34 | Culver, IN | |
| 1921 | W | Culver Military Academy (IN) | 30 | Loyola Academy (IL) | 0 | ? | |
| 1921 | W | Culver Military Academy (IN) | 50 | Notre Dame Walsh Hall (IN) | 0 | ? | |
| 1921 | T | Culver Military Academy (IN) | 7 | Rose-Hulman Tech (IN) | 7 | Culver, IN | |
| 1921 | L | Culver Military Academy (IN) | 3 | Notre Dame Freshmen (IN) | 48 | Culver, IN | |
| 1921 | W | Culver-Stockton (MO) | 2 | Lombard JV (IL) | 0 | ? | |
| 1921 | W | Culver-Stockton (MO) | 68 | Louisiana American Legion (MO) | 0 | ? | |
| 1921 | W | Culver-Stockton (MO) | 26 | Quincy (IL) | 0 | Quincy, IL | |
| 1921 | L | Culver-Stockton (MO) | 6 | Western Illinois | 14 | Canton, MO | |
| 1921 | L | Culver-Stockton (MO) | 0 | Truman St. (MO) | 20 | Kirksville, MO | |
| 1921 | L | Culver-Stockton (MO) | 4 | Hedding (IL) | 21 | Abingdon, IL | |
| 1921 | L | Culver-Stockton (MO) | 0 | Missouri Wesleyan | 65 | Cameron, MO | |
| 1921 | W | Cumberland (KY) | 33 | Eastern Kentucky | 0 | Williamsburg, KY | |
| 1921 | L | Cumberland (KY) | 7 | Georgetown (KY) | 31 | ? | |
| 1921 | L | Cumberland (KY) | 3 | Kentucky Wesleyan | 6 | ? | |
| 1921 | W | Cumberland (KY) | 13 | Kentucky Wesleyan | 6 | ? | |
| 1921 | W | Cumberland (KY) | 13 | Knoxville Central HS (TN) | 6 | ? | |
| 1921 | W | Cumberland (KY) | 51 | Middlesboro HS (KY) | 0 | ? | |
| 1921 | L | Cumberland (KY) | 0 | Somerset HS (KY) | 20 | ? | |
| 1921 | T | Cumberland (KY) | 7 | Maryville (TN) | 7 | Williamsburg, KY | |
| 1921 | L | Cumberland (TN) | 0 | Bethel (KY) | 14 | ? | |
| 1921 | W | Cumberland (TN) | 14 | Bryson (TN) | 0 | ? | |
| 1921 | T | Cumberland (TN) | 0 | Carthage AC (TN) | 0 | ? | |
| 1921 | L | Cumberland (TN) | 0 | Rhodes (TN) | 13 | ? | |
| 1921 | W | Cumberland (TN) | 19 | Union (TN) | 7 | ? | |
| 1921 | L | Cumberland (TN) | 0 | Sewanee (TN) | 28 | Sewanee, TN | |
| 1921 | L | Cumberland (TN) | 7 | Maryville (TN) | 47 | Maryville, TN | |
| 1921 | L | Cumberland HS | 0 | Huntingdon HS (PA) | 62 | ? | |
| 1921 | W | Curwensville HS (PA) | 38 | Bellwood HS (PA) | 6 | ? | |
| 1921 | T | Curwensville HS (PA) | 0 | Clymer Independents (PA) | 0 | ? | |
| 1921 | L | Curwensville HS (PA) | 0 | DuBois HS (PA) | 20 | ? | |
| 1921 | L | Curwensville HS (PA) | 0 | Indiana (PA) | 47 | ? | |
| 1921 | L | Curwensville HS (PA) | 0 | Ridgeway HS (PA) | 69 | ? | |
| 1921 | W | Curwensville HS (PA) | 57 | Roaring Springs HS (PA) | 6 | ? | |
| 1921 | L | Curwensville HS (PA) | 0 | Tyrone HS (PA) | 6 | ? | |
| 1921 | W | Curwensville HS (PA) | 31 | Tyrone HS (PA) | 0 | ? | |
| 1921 | W | Cushing Academy (MA) | 14 | Colby Academy (NH) | 0 | ? | |
| 1921 | L | Cushing Academy (MA) | 0 | Dean Academy (MA) | 19 | ? | |
| 1921 | W | Cushing Academy (MA) | 14 | Deerfield Academy (MA) | 0 | ? | |
| 1921 | W | Cushing Academy (MA) | 20 | Huntington School (MA) | 13 | ? | |
| 1921 | W | Cushing Academy (MA) | 6 | Saint Anselm Prep | 0 | ? | |
| 1921 | W | Cushing Academy (MA) | 13 | Suffield School (CT) | 7 | ? | |
| 1921 | W | Cushing Academy (MA) | 7 | Williston Seminary (MA) | 0 | ? | |
| 1921 | L | Cushing Academy (MA) | 0 | Worcester Academy (MA) | 27 | ? | |
| 1921 | L | Cuyahoga Falls HS (OH) | 6 | Warren HS (OH) | 14 | ? | |
| 1921 | W | Dakota Wesleyan (SD) | 14 | Northern St. (SD) | 0 | Aberdeen, SD | |
| 1921 | L | Dakota Wesleyan (SD) | 0 | South Dakota | 7 | Mitchell, SD | |
| 1921 | W | Dakota Wesleyan (SD) | 34 | South Dakota Tech | 0 | Mitchell, SD | |
| 1921 | W | Dakota Wesleyan (SD) | 6 | Westmar (IA) | 0 | LeMars, IA | |
| 1921 | W | Dakota Wesleyan (SD) | 22 | Yankton (SD) | 0 | Yankton, SD | |
| 1921 | L | Dakota Wesleyan (SD) | 0 | Creighton (NE) | 21 | Omaha, NE | |
| 1921 | W | Dakota Wesleyan (SD) | 32 | Buena Vista (IA) | 20 | Mitchell, SD | |
| 1921 | W | Dakota Wesleyan (SD) | 59 | Augustana (SD) | 6 | Sioux Falls, SD | MacLean Field |
| 1921 | L | Dalhart HS (TX) | 6 | Clayton HS (NM) | 13 | ? | |
| 1921 | L | Dalhart HS (TX) | 0 | Clayton HS (NM) | 12 | ? | |
| 1921 | W | Dallas (TX) | 14 | College of Marshall (TX) | 2 | Dallas, TX | |
| 1921 | L | Dallas (TX) | 0 | Daniel Baker (TX) | 27 | ? | |
| 1921 | W | Dallas (TX) | 1 | Meridian College (TX) | 0 | ? | Meridian College Forfeits |
| 1921 | W | Dallas (TX) | 34 | Saint Edward's (TX) | 0 | Dallas, TX | |
| 1921 | L | Dallas (TX) | 0 | Southeastern Oklahoma St. | 24 | ? | |
| 1921 | W | Dallas (TX) | 20 | Texas-Arlington | 0 | ? | |
| 1921 | T | Dallas (TX) | 7 | Wesley College (TX) | 7 | ? | |
| 1921 | L | Dallas (TX) | 0 | Trinity (TX) | 17 | Waxahachie, TX | |
| 1921 | W | Dallas (TX) | 20 | Abilene Christian (TX) | 0 | Abilene, TX | |
| 1921 | W | Dallas (TX) | 6 | Texas A&M-Commerce | 3 | Commerce, TX | |
| 1921 | W | Dallas HS (SD) | 44 | Burke HS (SD) | 0 | ? | |
| 1921 | W | Dallas HS (SD) | 20 | Geddes HS (SD) | 0 | ? | |
| 1921 | L | Dallas HS (SD) | 6 | Gregory HS (SD) | 7 | ? | |
| 1921 | W | Dallas HS (SD) | 7 | Gregory HS (SD) | 0 | ? | |
| 1921 | W | Dallas HS (SD) | 88 | Platte HS (SD) | 0 | ? | |
| 1921 | W | Dallas HS (SD) | 42 | Springview HS (NE) | 0 | ? | |
| 1921 | W | Dallas HS (SD) | 45 | Winner HS (SD) | 0 | ? | |
| 1921 | W | Dallas HS (SD) | 34 | Winner HS (SD) | 0 | ? | |
| 1921 | W | Daniel Baker (TX) | 55 | Abilene Christian (TX) | 0 | Brownwood, TX | |
| 1921 | W | Daniel Baker (TX) | 27 | Dallas (TX) | 0 | ? | |
| 1921 | L | Daniel Baker (TX) | 21 | Hardin-Simmons (TX) | 24 | Brownwood, TX | |
| 1921 | W | Daniel Baker (TX) | 34 | Meridian College (TX) | 0 | Brownwood, TX | |
| 1921 | L | Daniel Baker (TX) | 3 | Texas St. | 28 | San Marcos, TX | |
| 1921 | T | Daniel Baker (TX) | 0 | Saint Edward's (TX) | 0 | Brownwood, TX | |
| 1921 | L | Daniel Baker (TX) | 7 | John Tarleton College (TX) | 13 | Brownwood, TX | |
| 1921 | L | Daniel Baker (TX) | 0 | Trinity (TX) | 7 | San Antonio, TX | |
| 1921 | T | Danville HS (IL) | 14 | Georgetown HS (IL) | 14 | ? | |
| 1921 | W | Danville HS (IL) | 14 | Hoopeston HS (IL) | 2 | ? | |
| 1921 | L | Danville HS (IL) | 9 | Kankakee HS (IL) | 16 | ? | |
| 1921 | W | Danville HS (IL) | 80 | Oakwood HS (IL) | 0 | ? | |
| 1921 | W | Danville HS (IL) | 34 | Taylorville HS (IL) | 0 | ? | |
| 1921 | L | Danville HS (IL) | 2 | Urbana HS (IL) | 34 | ? | |
| 1921 | W | Danville HS (IL) | 39 | Villa Grove HS (IL) | 0 | ? | |
| 1921 | T | Danville HS (IL) | 7 | Watseka HS (IL) | 7 | ? | |
| 1921 | T | Danville HS (VA) | 0 | Roanoke HS (VA) | 0 | ? | |
| 1921 | L | Danville HS (VA) | 6 | Salem HS (VA) | 14 | ? | |
| 1921 | L | Darby HS (PA) | 0 | Abington HS (PA) | 14 | ? | |
| 1921 | W | Darby HS (PA) | 14 | Cheltenham HS (PA) | 0 | ? | |
| 1921 | T | Darby HS (PA) | 7 | Chester HS (PA) | 7 | ? | |
| 1921 | W | Darby HS (PA) | 13 | Haverford HS (PA) | 0 | ? | |
| 1921 | L | Darby HS (PA) | 0 | Lansdowne HS (PA) | 28 | ? | |
| 1921 | L | Darby HS (PA) | 13 | Media HS (PA) | 16 | ? | |
| 1921 | L | Darby HS (PA) | 0 | Ridley Park HS (PA) | 7 | ? | |
| 1921 | W | Darby HS (PA) | 34 | Swarthmore HS (PA) | 0 | ? | |
| 1921 | W | Darby HS (PA) | 14 | Upper Darby HS (PA) | 0 | ? | |
| 1921 | L | Dardanelle HS (AR) | 0 | Russellville HS (AR) | 40 | ? | |
| 1921 | L | Darlington HS (SC) | 0 | Charleston HS (SC) | 54 | ? | |
| 1921 | W | Dartmouth (NH) | 31 | Columbia (NY) | 7 | Hanover, NH | |
| 1921 | L | Dartmouth (NH) | 7 | Cornell (NY) | 59 | Ithaca, NY | |
| 1921 | W | Dartmouth (NH) | 7 | Georgia | 0 | Atlanta, GA | |
| 1921 | W | Dartmouth (NH) | 34 | Norwich (VT) | 3 | Hanover, NH | |
| 1921 | L | Dartmouth (NH) | 7 | Syracuse (NY) | 14 | New York, NY | |
| 1921 | W | Dartmouth (NH) | 14 | Tennessee | 3 | Hanover, NH | |
| 1921 | W | Dartmouth (NH) | 28 | Middlebury (VT) | 3 | Hanover, NH | |
| 1921 | W | Dartmouth (NH) | 24 | New Hampshire | 0 | Hanover, NH | |
| 1921 | T | Dartmouth (NH) | 14 | Pennsylvania | 14 | Hanover, NH | |
| 1921 | L | Davenport Battery B (IA) | 0 | Saint Ambrose (IA) | 26 | Davenport, IA | |
| 1921 | W | Davidson (NC) | 47 | Elon (NC) | 0 | Davidson, NC | |
| 1921 | L | Davidson (NC) | 0 | Furman (SC) | 28 | Greenville, SC | |
| 1921 | W | Davidson (NC) | 7 | Presbyterian (SC) | 0 | Davidson, NC | |
| 1921 | T | Davidson (NC) | 14 | Richmond (VA) | 14 | Richmond, VA | |
| 1921 | L | Davidson (NC) | 0 | Virginia | 28 | Charlottesville, VA | |
| 1921 | L | Davidson (NC) | 7 | Wake Forest (NC) | 10 | Charlotte, NC | |
| 1921 | W | Davidson (NC) | 87 | Wofford (SC) | 0 | Davidson, NC | |
| 1921 | T | Davidson (NC) | 3 | North Carolina St. | 3 | Charlotte, NC | |
| 1921 | L | Davidson (NC) | 0 | Georgia Tech | 70 | Atlanta, GA | |
| 1921 | T | Davidson (NC) | 0 | North Carolina | 0 | Winston-Salem, NC | |
| 1921 | W | Davis & Elkins (WV) | 6 | Broaddus College (WV) | 0 | ? | |
| 1921 | W | Davis & Elkins (WV) | 21 | Fairmont St. (WV) | 0 | ? | |
| 1921 | L | Davis & Elkins (WV) | 0 | Marietta (OH) | 48 | ? | |
| 1921 | T | Davis & Elkins (WV) | 0 | Potomac St. (WV) | 0 | ? | |
| 1921 | L | Davis & Elkins (WV) | 0 | Salem College (WV) | 16 | ? | |
| 1921 | W | Davis & Elkins (WV) | 40 | West Virginia Freshmen | 0 | ? | |
| 1921 | L | Davis & Elkins (WV) | 0 | Mount Saint Mary's (MD) | 27 | Emmitsburg, MD | |
| 1921 | L | Davis & Elkins (WV) | 0 | Charleston (WV) | 21 | Barboursville, WV | |
| 1921 | W | Davis & Elkins JV (WV) | 13 | Belington HS (WV) | 0 | ? | |
| 1921 | L | Davis County HS (UT) | 0 | Ogden HS (UT) | 20 | ? | |
| 1921 | L | Davis County HS (UT) | 0 | Salt Lake City East Side HS (UT) | 41 | ? | |
| 1921 | L | Dawson Springs HS (KY) | 0 | Sturgis HS (KY) | 45 | ? | |
| 1921 | L | Dayton (OH) | 0 | Bethany (WV) | 78 | Bethany, WV | |
| 1921 | L | Dayton (OH) | 0 | Hanover (IN) | 3 | ? | |
| 1921 | W | Dayton (OH) | 13 | John Carroll (OH) | 6 | Dayton, OH | |
| 1921 | L | Dayton (OH) | 14 | Muskingum (OH) | 30 | New Concord, OH | |
| 1921 | L | Dayton (OH) | 0 | Wilmington (OH) | 30 | ? | |
| 1921 | L | Dayton (OH) | 0 | Miami (OH) | 55 | Oxford, OH | |
| 1921 | T | Dayton (OH) | 14 | Earlham (IN) | 14 | Richmond, IN | |
| 1921 | L | Dayton (OH) | 0 | Xavier (OH) | 13 | Dayton, OH | |
| 1921 | L | Dayton (OH) | 0 | Baldwin-Wallace (OH) | 7 | Berea, OH | |
| 1921 | W | Dayton Steele HS (OH) | 24 | Chicago Englewood HS (IL) | 7 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 31 | Columbus North HS (OH) | 0 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 112 | Columbus South HS (OH) | 0 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 26 | Dayton Stivers Manual Training HS (OH) | 6 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 83 | Elyria HS (OH) | 7 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 49 | Indianapolis Arsenal Technical School (IN) | 14 | ? | |
| 1921 | L | Dayton Steele HS (OH) | 0 | Jacksonville Duval HS (FL) | 21 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 68 | Massillon HS (OH) | 0 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 14 | Toledo Waite HS (OH) | 7 | ? | |
| 1921 | W | Dayton Steele HS (OH) | 109 | Wabash HS (IN) | 6 | ? | |
| 1921 | L | Dayton Stivers Manual Training HS (OH) | 6 | Dayton Steele HS (OH) | 26 | ? | |
| 1921 | L | Dayton Stivers Manual Training HS (OH) | 13 | Huntington HS (WV) | 21 | ? | |
| 1921 | L | Dayton Stivers Manual Training HS (OH) | 3 | Toledo Waite HS (OH) | 13 | ? | |
| 1921 | L | De La Rosas HS | 0 | Mount Diablo HS (CA) | 76 | ? | |
| 1921 | L | De Smet HS (SD) | 7 | Clark HS (SD) | 13 | ? | |
| 1921 | L | Deadwood HS (SD) | 3 | Belle Fourche HS (SD) | 40 | ? | |
| 1921 | L | Deadwood HS (SD) | 7 | Belle Fourche HS (SD) | 28 | ? | |
| 1921 | L | Deadwood HS (SD) | 0 | Lead HS (SD) | 37 | ? | |
| 1921 | W | Deadwood HS (SD) | 6 | Lead HS (SD) | 0 | ? | |
| 1921 | W | Dean Academy (MA) | 19 | Cushing Academy (MA) | 0 | ? | |
| 1921 | L | Dean Academy JV (MA) | 0 | Waltham HS (MA) | 17 | ? | |
| 1921 | L | Dean Academy JV (MA) | 0 | Cambridge Latin & HS (MA) | 14 | Franklin, MA | |
| 1921 | L | Decatur Baptist College (TX) | 0 | John Tarleton College (TX) | 38 | ? | |
| 1921 | L | Decatur Baptist College (TX) | 0 | Terrill Prep School (TX) | 20 | ? | |
| 1921 | L | Decatur HS (IL) | 6 | Peoria Central HS (IL) | 45 | ? | |
| 1921 | W | Dedham HS (MA) | 40 | Belmont HS (MA) | 0 | ? | |
| 1921 | W | Dedham HS (MA) | 7 | Boston Hyde Park HS (MA) | 6 | ? | |
| 1921 | T | Dedham HS (MA) | 0 | Brighton HS (MA) | 0 | ? | |
| 1921 | L | Dedham HS (MA) | 6 | Mansfield HS (MA) | 7 | ? | |
| 1921 | L | Dedham HS (MA) | 6 | Norwood HS (MA) | 21 | ? | |
| 1921 | L | Dedham HS (MA) | 6 | Watertown HS (MA) | 7 | ? | |
| 1921 | L | Deerfield Academy (MA) | 0 | Cushing Academy (MA) | 14 | ? | |
| 1921 | L | Deerfield Shields HS (IL) | 14 | Brockton HS (MA) | 19 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 14 | Chicago Lindblom HS (IL) | 6 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 34 | Evanston HS (IL) | 3 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 40 | La Grange HS (IL) | 0 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 43 | New Trier HS | 0 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 14 | Oak Park HS (IL) | 0 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 27 | Proviso Township HS (IL) | 0 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 28 | Riverside HS (IL) | 0 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 46 | Thornton HS (IL) | 0 | ? | |
| 1921 | W | Deerfield Shields HS (IL) | 21 | Waukegan HS (IL) | 0 | ? | |
| 1921 | L | Deering HS | 0 | Portland HS (ME) | 7 | ? | |
| 1921 | W | Deering HS | 7 | Portland HS (ME) | 6 | ? | |
| 1921 | W | Defiance (OH) | 57 | Cedarville (OH) | 0 | ? | |
| 1921 | W | Defiance (OH) | 119 | Findlay (OH) | 0 | Findlay, OH | |
| 1921 | T | Defiance (OH) | 0 | Heidelberg (OH) | 0 | Tiffin, OH | |
| 1921 | L | Defiance (OH) | 0 | Hillsdale (MI) | 35 | Hillsdale, MI | |
| 1921 | L | Defiance (OH) | 0 | Toledo (OH) | 40 | Toledo, OH | |
| 1921 | L | Defiance (OH) | 0 | Muskingum (OH) | 34 | New Concord, OH | |
| 1921 | W | Defiance (OH) | 1 | Assumption College (ON) | 0 | Defiance, OH | Assumption College Forfeits |
| 1921 | L | Defiance (OH) | 0 | Bowling Green (OH) | 7 | Defiance, OH | |
| 1921 | L | Defiance (OH) | 0 | Wilmington (OH) | 14 | Wilmington, OH | |
| 1921 | L | DeKalb HS (IL) | 0 | Elgin HS (IL) | 35 | ? | |
| 1921 | L | DeKalb HS (IL) | 0 | Freeport HS (IL) | 16 | ? | |
| 1921 | L | DeLaSalle HS | 0 | Dunwoody College of Tech. (MN) | 33 | ? | |
| 1921 | W | Delaware | 13 | Haverford (PA) | 0 | Haverford, PA | |
| 1921 | L | Delaware | 0 | Pennsylvania | 89 | Philadelphia, PA | |
| 1921 | W | Delaware | 49 | SUNY-Farmingdale (NY) | 0 | Newark, DE | |
| 1921 | W | Delaware | 47 | Washington (MD) | 0 | Newark, DE | |
| 1921 | W | Delaware | 6 | Widener (PA) | 0 | Wilmington, DE | |
| 1921 | L | Delaware | 0 | Muhlenberg (PA) | 21 | Newark, DE | |
| 1921 | W | Delaware | 48 | McDaniel College (MD) | 6 | Newark, DE | |
| 1921 | L | Delaware | 0 | Johns Hopkins (MD) | 27 | Baltimore, MD | |
| 1921 | L | Delaware | 0 | Lafayette (PA) | 44 | Easton, PA | |
| 1921 | L | Delaware HS (OH) | 0 | Columbus South HS (OH) | 7 | ? | |
| 1921 | W | Delaware HS (OK) | 6 | Collinsville HS (OK) | 0 | ? | |
| 1921 | W | Delaware Valley (PA) | 33 | Atlantic City HS (NJ) | 0 | ? | |
| 1921 | W | Delaware Valley (PA) | 7 | Lafayette Freshmen (PA) | 0 | ? | |
| 1921 | L | Delaware Valley (PA) | 0 | Lancaster HS (PA) | 10 | ? | |
| 1921 | W | Delaware Valley (PA) | 7 | New Jersey School for the Deaf | 0 | ? | |
| 1921 | W | Delaware Valley (PA) | 1 | Pennington Seminary (NJ) | 0 | ? | Pennington Seminary Forfeits |
| 1921 | W | Delaware Valley (PA) | 27 | Pennsylvania Institution for the Deaf | 0 | ? | |
| 1921 | W | Delaware Valley (PA) | 7 | Quakertown HS (PA) | 0 | ? | |
| 1921 | L | Delaware Valley (PA) | 7 | Swarthmore Prep School (PA) | 13 | ? | |
| 1921 | T | Delaware Valley (PA) | 7 | Villanova Prep School (PA) | 7 | ? | |
| 1921 | W | Delphos HS (OH) | 22 | Saint Marys HS (OH) | 6 | ? | |
| 1921 | L | Delta HS (CO) | 3 | Gunnison HS (CO) | 6 | ? | |
| 1921 | L | Delta HS (CO) | 3 | Olathe HS (CO) | 33 | ? | |
| 1921 | L | Deming HS (NM) | 0 | El Paso HS (TX) | 14 | ? | |
| 1921 | W | Denison (OH) | 7 | Heidelberg (OH) | 0 | Granville, OH | |
| 1921 | L | Denison (OH) | 6 | Miami (OH) | 21 | Dayton, OH | |
| 1921 | W | Denison (OH) | 14 | Ohio | 7 | Granville, OH | |
| 1921 | W | Denison (OH) | 49 | Otterbein (OH) | 0 | Granville, OH | |
| 1921 | L | Denison (OH) | 6 | Butler (IN) | 19 | Granville, OH | Deed's Field |
| 1921 | W | Denison (OH) | 7 | Ohio Wesleyan | 0 | Delaware, OH | |
| 1921 | L | Denison (OH) | 0 | Wooster (OH) | 31 | Wooster, OH | |
| 1921 | W | Denison (OH) | 7 | Cincinnati (OH) | 0 | Cincinnati, OH | |
| 1921 | L | Denver (CO) | 7 | Colorado | 10 | Boulder, CO | |
| 1921 | L | Denver (CO) | 21 | Colorado College | 28 | Colorado Springs, CO | |
| 1921 | W | Denver (CO) | 21 | Nebraska Wesleyan | 3 | Denver, CO | |
| 1921 | T | Denver (CO) | 9 | Wyoming | 9 | Denver, CO | |
| 1921 | W | Denver (CO) | 41 | Fort Hays St. (KS) | 7 | Denver, CO | |
| 1921 | W | Denver (CO) | 21 | Colorado St. | 14 | Fort Collins, CO | |
| 1921 | W | Denver (CO) | 13 | Colorado School of Mines | 7 | Denver, CO | |
| 1921 | W | Denver East HS (CO) | 18 | Boulder Prep School (CO) | 0 | ? | |
| 1921 | L | Denver East HS (CO) | 0 | Colorado Springs HS (CO) | 21 | ? | |
| 1921 | L | Denver East HS (CO) | 0 | Denver South HS (CO) | 18 | ? | |
| 1921 | L | Denver East HS (CO) | 10 | Greeley HS (CO) | 27 | ? | |
| 1921 | L | Denver East HS (CO) | 0 | Regis (CO) | 21 | ? | |
| 1921 | W | Denver Freshmen (CO) | 62 | Northern Colorado | 10 | Greeley, CO | |
| 1921 | L | Denver Freshmen (CO) | 0 | Regis (CO) | 3 | ? | |
| 1921 | W | Denver Freshmen (CO) | 7 | Regis (CO) | 0 | ? | |
| 1921 | L | Denver Manual HS (CO) | 0 | Canon City HS (CO) | 44 | ? | |
| 1921 | L | Denver Manual HS (CO) | 0 | Colorado Springs HS (CO) | 72 | ? | |
| 1921 | L | Denver Manual HS (CO) | 0 | Denver South HS (CO) | 28 | ? | |
| 1921 | L | Denver Manual HS (CO) | 0 | Regis (CO) | 21 | ? | |
| 1921 | L | Denver North HS (CO) | 0 | Canon City HS (CO) | 96 | ? | |
| 1921 | L | Denver North HS (CO) | 0 | Denver South HS (CO) | 28 | ? | |
| 1921 | W | Denver South HS (CO) | 28 | Boulder Prep School (CO) | 6 | ? | |
| 1921 | W | Denver South HS (CO) | 18 | Denver East HS (CO) | 0 | ? | |
| 1921 | W | Denver South HS (CO) | 28 | Denver Manual HS (CO) | 0 | ? | |
| 1921 | W | Denver South HS (CO) | 28 | Denver North HS (CO) | 0 | ? | |
| 1921 | W | Denver South HS (CO) | 7 | Denver West HS (CO) | 3 | ? | |
| 1921 | L | Denver South HS (CO) | 0 | Greeley HS (CO) | 7 | ? | |
| 1921 | T | Denver West HS (CO) | 0 | Colorado Springs HS (CO) | 0 | ? | |
| 1921 | L | Denver West HS (CO) | 3 | Denver South HS (CO) | 7 | ? | |
| 1921 | L | Denver West HS (CO) | 10 | Greeley HS (CO) | 48 | ? | |
| 1921 | L | Denver West HS (CO) | 0 | Regis (CO) | 21 | ? | |
| 1921 | L | DePaul (IL) | 0 | Chicago YMCA College (IL) | 50 | ? | |
| 1921 | L | DePaul (IL) | 0 | Great Lakes NTS (IL) | 20 | ? | |
| 1921 | L | DePaul (IL) | 7 | Haverhill Saint James HS (MA) | 14 | Haverhill, MA | |
| 1921 | L | DePaul (IL) | 0 | Loras (IA) | 14 | Dubuque, IA | |
| 1921 | L | DePaul (IL) | 0 | Northwestern (IL) | 34 | Evanston, IL | |
| 1921 | L | DePaul (IL) | 7 | Lake Forest (IL) | 26 | Chicago, IL | |
| 1921 | L | DePaul (IL) | 0 | Saint Viator (IL) | 19 | Chicago, IL | |
| 1921 | L | DePaul (IL) | 0 | Lombard (IL) | 27 | Chicago, IL | |
| 1921 | W | DePauw (IN) | 67 | Georgetown (KY) | 0 | Greencastle, IN | |
| 1921 | W | DePauw (IN) | 21 | Saint Louis (MO) | 7 | Saint Louis, MO | |
| 1921 | W | DePauw (IN) | 41 | Valparaiso (IN) | 0 | Greencastle, IN | |
| 1921 | L | DePauw (IN) | 0 | Wabash (IN) | 22 | Indianapolis, IN | |
| 1921 | L | DePauw (IN) | 10 | Notre Dame (IN) | 57 | South Bend, IN | |
| 1921 | L | DePauw (IN) | 0 | Illinois | 21 | Urbana, IL | |
| 1921 | W | DePauw (IN) | 28 | Transylvania (KY) | 0 | Greencastle, IN | |
| 1921 | L | Derby HS (CT) | 0 | Bridgeport HS (CT) | 33 | ? | |
| 1921 | L | Derby HS (CT) | 0 | Crosby HS (CT) | 28 | ? | |
| 1921 | L | Derby HS (CT) | 0 | Stamford HS (CT) | 35 | ? | |
| 1921 | L | Derby HS (CT) | 0 | Torrington HS (CT) | 19 | ? | |
| 1921 | L | DeRidder HS (LA) | 0 | Beaumont HS (TX) | 33 | ? | |
| 1921 | L | Derma HS (MS) | 0 | Ackerman HS (MS) | 14 | ? | |
| 1921 | W | Des Moines (IA) | 24 | Haskell Indian Nations (KS) | 7 | Kansas City, MO | |
| 1921 | L | Des Moines (IA) | 0 | Lombard (IL) | 7 | ? | |
| 1921 | L | Des Moines (IA) | 0 | Morningside (IA) | 14 | Sioux City, IA | |
| 1921 | W | Des Moines (IA) | 38 | Still College (IA) | 0 | ? | |
| 1921 | W | Des Moines (IA) | 34 | Parsons (IA) | 0 | Des Moines, IA | |
| 1921 | W | Des Moines (IA) | 27 | William Penn (IA) | 7 | Des Moines, IA | |
| 1921 | L | Des Moines (IA) | 0 | Creighton (NE) | 28 | Des Moines, IA | |
| 1921 | W | Des Moines (IA) | 7 | Dubuque (IA) | 0 | Dubuque, IA | |
| 1921 | T | Des Moines North HS (IA) | 0 | Waterloo East HS (IA) | 0 | ? | |
| 1921 | L | Des Plaines HS (IL) | 7 | Thornton HS (IL) | 10 | ? | |
| 1921 | W | Detroit (MI) | 28 | Boston College (MA) | 0 | Chestnut Hill, MA | |
| 1921 | W | Detroit (MI) | 14 | Tulane (LA) | 10 | Detroit, MI | |
| 1921 | W | Detroit (MI) | 21 | Vermont | 0 | Detroit, MI | |
| 1921 | W | Detroit (MI) | 55 | West Virginia Wesleyan | 0 | Detroit, MI | |
| 1921 | W | Detroit (MI) | 35 | Franklin (IN) | 0 | Detroit, MI | |
| 1921 | L | Detroit (MI) | 2 | Washington & Jefferson (PA) | 14 | Detroit, MI | |
| 1921 | W | Detroit (MI) | 21 | Springfield (MA) | 0 | Detroit, MI | |
| 1921 | W | Detroit (MI) | 35 | Ohio Northern | 0 | Detroit, MI | |
| 1921 | W | Detroit (MI) | 34 | Marietta (OH) | 0 | Detroit, MI | |
| 1921 | T | Detroit Cass Tech (MI) | 6 | Detroit Central HS (MI) | 6 | ? | |
| 1921 | L | Detroit Cass Tech (MI) | 0 | Detroit Northern HS (MI) | 16 | ? | |
| 1921 | L | Detroit Cass Tech (MI) | 6 | Detroit Northwestern HS (MI) | 13 | ? | |
| 1921 | W | Detroit Cass Tech (MI) | 34 | Flint Central HS (MI) | 20 | ? | |
| 1921 | T | Detroit Central HS (MI) | 6 | Detroit Cass Tech (MI) | 6 | ? | |
| 1921 | L | Detroit Central HS (MI) | 0 | Detroit Eastern HS (MI) | 6 | ? | |
| 1921 | T | Detroit Central HS (MI) | 13 | Detroit Northern HS (MI) | 13 | ? | |
| 1921 | L | Detroit Central HS (MI) | 0 | Detroit Northwestern HS (MI) | 12 | ? | |
| 1921 | L | Detroit Central HS (MI) | 0 | Detroit Western HS (MI) | 28 | ? | |
| 1921 | L | Detroit Central HS (MI) | 0 | Lansing HS (MI) | 35 | ? | |
| 1921 | L | Detroit Central HS (MI) | 0 | Pontiac HS (MI) | 28 | ? | |
| 1921 | L | Detroit Central HS (MI) | 0 | Saginaw Arthur Hill HS (MI) | 35 | ? | |
| 1921 | W | Detroit Eastern HS (MI) | 6 | Detroit Central HS (MI) | 0 | ? | |
| 1921 | L | Detroit Eastern HS (MI) | 0 | Detroit Northern HS (MI) | 7 | ? | |
| 1921 | L | Detroit Eastern HS (MI) | 6 | Detroit Northwestern HS (MI) | 17 | ? | |
| 1921 | L | Detroit Eastern HS (MI) | 0 | Muskegon HS (MI) | 48 | ? | |
| 1921 | L | Detroit HS (MN) | 0 | Moorhead HS (MN) | 45 | ? | |
| 1921 | L | Detroit HS (MN) | 0 | Wadena HS (MN) | 7 | ? | |
| 1921 | W | Detroit Northeastern HS (MI) | 19 | Birmingham HS (MI) | 0 | ? | |
| 1921 | T | Detroit Northeastern HS (MI) | 6 | Detroit Northeastern HS Alumni (MI) | 6 | ? | |
| 1921 | W | Detroit Northeastern HS (MI) | 7 | Detroit Southeastern HS (MI) | 6 | ? | |
| 1921 | W | Detroit Northeastern HS (MI) | 13 | Detroit Southwestern HS (MI) | 0 | ? | |
| 1921 | W | Detroit Northeastern HS (MI) | 7 | Highland Park HS (MI) | 0 | ? | |
| 1921 | T | Detroit Northeastern HS (MI) | 0 | Mount Clemens HS (MI) | 0 | ? | |
| 1921 | L | Detroit Northeastern HS (MI) | 0 | Royal Oak HS (MI) | 13 | ? | |
| 1921 | L | Detroit Northeastern HS (MI) | 0 | Windsor | 7 | ? | |
| 1921 | W | Detroit Northeastern HS (MI) | 13 | Ypsilanti HS (MI) | 0 | ? | |
| 1921 | T | Detroit Northeastern HS Alumni (MI) | 6 | Detroit Northeastern HS (MI) | 6 | ? | |
| 1921 | W | Detroit Northern HS (MI) | 16 | Detroit Cass Tech (MI) | 0 | ? | |
| 1921 | T | Detroit Northern HS (MI) | 13 | Detroit Central HS (MI) | 13 | ? | |
| 1921 | W | Detroit Northern HS (MI) | 7 | Detroit Eastern HS (MI) | 0 | ? | |
| 1921 | W | Detroit Northern HS (MI) | 14 | Detroit Northwestern HS (MI) | 13 | ? | |
| 1921 | W | Detroit Northern HS (MI) | 1 | Detroit Western HS (MI) | 0 | ? | Detroit Western HS Forfeits |
| 1921 | L | Detroit Northern HS (MI) | 0 | Grand Rapids Central HS (MI) | 49 | ? | |
| 1921 | W | Detroit Northern HS (MI) | 21 | Ypsilanti HS (MI) | 0 | ? | |
| 1921 | W | Detroit Northwestern HS (MI) | 13 | Detroit Cass Tech (MI) | 6 | ? | |
| 1921 | W | Detroit Northwestern HS (MI) | 12 | Detroit Central HS (MI) | 0 | ? | |
| 1921 | W | Detroit Northwestern HS (MI) | 17 | Detroit Eastern HS (MI) | 6 | ? | |
| 1921 | L | Detroit Northwestern HS (MI) | 13 | Detroit Northern HS (MI) | 14 | ? | |
| 1921 | T | Detroit Northwestern HS (MI) | 0 | Detroit Western HS (MI) | 0 | ? | |
| 1921 | W | Detroit Northwestern HS (MI) | 49 | Grand Rapids South HS (MI) | 0 | ? | |
| 1921 | W | Detroit Northwestern HS (MI) | 45 | Port Huron HS (MI) | 0 | ? | |
| 1921 | W | Detroit Northwestern HS (MI) | 38 | Saginaw East HS (MI) | 10 | ? | |
| 1921 | L | Detroit Southeastern HS (MI) | 6 | Detroit Northeastern HS (MI) | 7 | ? | |
| 1921 | L | Detroit Southeastern HS (MI) | 0 | Flint Central HS (MI) | 28 | ? | |
| 1921 | L | Detroit Southwestern HS (MI) | 0 | Detroit Northeastern HS (MI) | 13 | ? | |
| 1921 | W | Detroit Western HS (MI) | 28 | Detroit Central HS (MI) | 0 | ? | |
| 1921 | L | Detroit Western HS (MI) | 0 | Detroit Northern HS (MI) | 1 | ? | Detroit Western HS Forfeits |
| 1921 | T | Detroit Western HS (MI) | 0 | Detroit Northwestern HS (MI) | 0 | ? | |
| 1921 | L | Detroit Western HS (MI) | 0 | Toledo Waite HS (OH) | 61 | ? | |
| 1921 | L | Dewey HS (OK) | 0 | Tulsa Central HS (OK) | 46 | ? | |
| 1921 | W | Dewitt Clinton HS (NY) | 7 | Columbus HS of Commerce (OH) | 0 | ? | |
| 1921 | W | Dewitt Clinton HS (NY) | 6 | Jersey City Dickinson HS (NJ) | 0 | ? | |
| 1921 | W | Dewitt Clinton HS (NY) | 7 | New York HS of Commerce (NY) | 0 | ? | |
| 1921 | W | Dewitt Clinton HS (NY) | 21 | New York Morris HS (NY) | 6 | ? | |
| 1921 | W | Dewitt Clinton HS (NY) | 13 | Newark East Side HS (NJ) | 6 | ? | |
| 1921 | W | Dewitt Clinton HS (NY) | 14 | Paterson HS (NJ) | 0 | ? | |
| 1921 | W | Dewitt Clinton HS (NY) | 13 | Stuyvesant HS (NY) | 0 | ? | |
| 1921 | L | Dickinson (PA) | 0 | Bucknell (PA) | 21 | Carlisle, PA | |
| 1921 | L | Dickinson (PA) | 0 | Gettysburg (PA) | 15 | Carlisle, PA | |
| 1921 | L | Dickinson (PA) | 0 | Johns Hopkins (MD) | 6 | Baltimore, MD | |
| 1921 | W | Dickinson (PA) | 20 | Ursinus (PA) | 0 | Collegeville, PA | |
| 1921 | W | Dickinson (PA) | 45 | Juniata (PA) | 0 | Carlisle, PA | |
| 1921 | L | Dickinson (PA) | 7 | Franklin & Marshall (PA) | 21 | Lancaster, PA | |
| 1921 | L | Dickinson (PA) | 0 | Lafayette (PA) | 27 | Easton, PA | |
| 1921 | W | Dickinson (PA) | 28 | Allegheny (PA) | 6 | Carlisle, PA | |
| 1921 | L | Dickinson HS (ND) | 0 | Williston HS (ND) | 103 | ? | |
| 1921 | L | Dickinson JV (PA) | 7 | Shippensburg (PA) | 14 | Shippensburg, PA | |
| 1921 | L | Dinuba HS (CA) | 0 | Bakersfield HS (CA) | 27 | ? | |
| 1921 | W | Dinuba HS (CA) | 13 | Fowler HS (CA) | 0 | ? | |
| 1921 | W | Dinuba HS (CA) | 90 | Fresno Tech HS (CA) | 0 | ? | |
| 1921 | L | Dinuba HS (CA) | 0 | Kern County HS (CA) | 27 | ? | |
| 1921 | W | Dinuba HS (CA) | 54 | Orosi HS (CA) | 0 | ? | |
| 1921 | L | Dinuba HS (CA) | 0 | Porterville HS (CA) | 21 | ? | |
| 1921 | W | Dinuba HS (CA) | 60 | Sanger HS (CA) | 0 | ? | |
| 1921 | W | Dinuba HS (CA) | 7 | Strathmore HS (CA) | 6 | ? | |
| 1921 | W | Dinuba HS (CA) | 20 | Strathmore HS (CA) | 0 | ? | |
| 1921 | W | Dinuba HS (CA) | 25 | Visalia HS (CA) | 0 | ? | |
| 1921 | W | Dinuba HS (CA) | 40 | Woodlake HS (CA) | 0 | ? | |
| 1921 | L | Doane (NE) | 13 | Benedictine (KS) | 21 | Atchison, KS | |
| 1921 | L | Doane (NE) | 7 | Cotner (NE) | 10 | Bethany, NE | |
| 1921 | T | Doane (NE) | 0 | Hastings (NE) | 0 | ? | |
| 1921 | W | Doane (NE) | 10 | Midland Lutheran (NE) | 6 | ? | |
| 1921 | W | Doane (NE) | 33 | Nebraska Central | 0 | ? | |
| 1921 | L | Doane (NE) | 0 | Nebraska Wesleyan | 3 | Crete, NE | |
| 1921 | W | Doane (NE) | 3 | Peru St. (NE) | 0 | ? | |
| 1921 | W | Doane (NE) | 17 | Trinity (IA) | 0 | ? | |
| 1921 | W | Doane (NE) | 10 | York (NE) | 6 | Crete, NE | |
| 1921 | W | Doane Academy (OH) | 20 | London HS (OH) | 0 | ? | |
| 1921 | L | Doane Academy (OH) | 0 | Rio Grande (OH) | 17 | ? | |
| 1921 | L | Dodge Center HS (MN) | 0 | Stewartville HS (MN) | 26 | ? | |
| 1921 | L | Dodge Center HS (MN) | 6 | Stewartville HS (MN) | 26 | ? | |
| 1921 | L | Dolgeville HS (NY) | 0 | Herkimer HS (NY) | 48 | ? | |
| 1921 | L | Donora HS (PA) | 13 | Washington HS (PA) | 20 | ? | |
| 1921 | L | Dorchester HS (MA) | 0 | Boston Latin School (MA) | 13 | ? | |
| 1921 | L | Dorchester HS (MA) | 0 | Middlesex School (MA) | 34 | ? | |
| 1921 | W | Dothan HS (AL) | 41 | Troy (AL) | 0 | Dothan, AL | |
| 1921 | L | Douglas HS (WY) | 0 | Casper HS (WY) | 60 | ? | |
| 1921 | L | Douglas HS (WY) | 6 | Casper HS (WY) | 54 | ? | |
| 1921 | L | Dover HS (NH) | 0 | Phillips Exeter Academy (NH) | 26 | ? | |
| 1921 | W | Dover HS (NH) | 7 | Phillips Exeter Academy (NH) | 6 | ? | |
| 1921 | W | Dover HS (NJ) | 7 | Chatham HS (NJ) | 0 | ? | |
| 1921 | L | Dover HS (NJ) | 0 | Dover HS Alumni (NJ) | 18 | ? | |
| 1921 | L | Dover HS (NJ) | 0 | Freehold HS (NJ) | 9 | ? | |
| 1921 | T | Dover HS (NJ) | 0 | Jersey City Dickinson HS (NJ) | 0 | ? | |
| 1921 | W | Dover HS (NJ) | 28 | Long Island Lawrence HS (NY) | 6 | ? | |
| 1921 | W | Dover HS (NJ) | 7 | Newton HS (NJ) | 0 | ? | |
| 1921 | T | Dover HS (NJ) | 0 | Nutley HS (NJ) | 0 | ? | |
| 1921 | W | Dover HS (NJ) | 14 | Ridgewood HS (NJ) | 13 | ? | |
| 1921 | W | Dover HS (NJ) | 49 | Roxbury HS (NJ) | 0 | ? | |
| 1921 | W | Dover HS (NJ) | 7 | South Orange Columbia HS (NJ) | 6 | ? | |
| 1921 | W | Dover HS (NJ) | 38 | Summit HS (NJ) | 0 | ? | |
| 1921 | W | Dover HS Alumni (NJ) | 18 | Dover HS (NJ) | 0 | ? | |
| 1921 | L | Dowagiac HS (MI) | 0 | Lansing HS (MI) | 26 | ? | |
| 1921 | W | Downers Grove HS (IL) | 2 | Thornton HS (IL) | 0 | ? | |
| 1921 | L | Downingtown HS (PA) | 0 | Pennsylvania Institution for the Deaf | 55 | ? | |
| 1921 | W | Drake (IA) | 41 | Cornell College (IA) | 0 | Des Moines, IA | |
| 1921 | W | Drake (IA) | 21 | Grinnell (IA) | 10 | Des Moines, IA | |
| 1921 | W | Drake (IA) | 15 | Kansas | 7 | Lawrence, KS | |
| 1921 | L | Drake (IA) | 0 | Missouri | 6 | Columbia, MO | |
| 1921 | L | Drake (IA) | 0 | Iowa St. | 7 | Des Moines, IA | |
| 1921 | W | Drake (IA) | 42 | William Penn (IA) | 0 | Oskaloosa, IA | |
| 1921 | W | Drake (IA) | 30 | Morningside (IA) | 10 | Des Moines, IA | |
| 1921 | L | Drayton HS (ND) | 7 | Stephen HS (MN) | 14 | ? | |
| 1921 | T | Drexel Institute (PA) | 14 | Gallaudet (DC) | 14 | Philadelphia, PA | |
| 1921 | L | Drexel Institute (PA) | 0 | George Washington (DC) | 41 | Philadelphia, PA | |
| 1921 | W | Drexel Institute (PA) | 13 | Juniata (PA) | 0 | Philadelphia, PA | |
| 1921 | L | Drexel Institute (PA) | 0 | Saint John's (MD) | 35 | Philadelphia, PA | |
| 1921 | W | Drexel Institute (PA) | 34 | SUNY-Farmingdale (NY) | 7 | Philadelphia, PA | |
| 1921 | L | Drexel Institute (PA) | 0 | McDaniel College (MD) | 14 | Westminster, MD | |
| 1921 | W | Drum Hill HS (NY) | 33 | Mohegan Lake HS (NY) | 12 | ? | |
| 1921 | W | Drum Hill HS (NY) | 10 | Nyack HS (NY) | 0 | ? | |
| 1921 | W | Drum Hill HS (NY) | 21 | Oakside HS | 0 | ? | |
| 1921 | W | Drum Hill HS (NY) | 38 | Peekskill Military Academy (NY) | 0 | ? | |
| 1921 | W | Drum Hill HS (NY) | 26 | Port Chester HS (NY) | 13 | ? | |
| 1921 | L | Drum Hill HS (NY) | 0 | Stamford HS (CT) | 13 | ? | |
| 1921 | W | Drum Hill HS (NY) | 24 | Washington Irving HS | 21 | ? | |
| 1921 | L | Drury (MO) | 13 | Missouri St. | 16 | Springfield, MO | |
| 1921 | T | Drury (MO) | 7 | Missouri Valley | 7 | Marshall, MO | |
| 1921 | L | Drury (MO) | 0 | William Jewell (MO) | 17 | Liberty, MO | |
| 1921 | W | Drury (MO) | 47 | Central Wesleyan (MO) | 0 | Springfield, MO | |
| 1921 | W | Drury (MO) | 34 | Ozark Wesleyan (MO) | 13 | Marionville, MO | |
| 1921 | L | Drury (MO) | 0 | Central Missouri St. | 14 | Springfield, MO | |
| 1921 | L | Drury (MO) | 0 | Arkansas | 40 | Fayetteville, AR | |
| 1921 | L | Drury (MO) | 0 | Missouri S&T | 31 | Rolla, MO | |
| 1921 | L | Dublin HS (GA) | 0 | Athens HS (GA) | 42 | ? | |
| 1921 | L | DuBois HS (PA) | 0 | Clarion (PA) | 6 | DuBois, PA | |
| 1921 | W | DuBois HS (PA) | 8 | Clearfield HS (PA) | 7 | ? | |
| 1921 | W | DuBois HS (PA) | 20 | Curwensville HS (PA) | 0 | ? | |
| 1921 | L | DuBois HS (PA) | 0 | Huntingdon HS (PA) | 1 | ? | |
| 1921 | W | DuBois HS (PA) | 3 | Indiana (PA) | 0 | ? | |
| 1921 | L | Dubuque (IA) | 7 | Coe (IA) | 28 | Cedar Rapids, IA | |
| 1921 | T | Dubuque (IA) | 0 | Cornell College (IA) | 0 | Mount Vernon, IA | |
| 1921 | W | Dubuque (IA) | 7 | Myers Bears | 0 | Dubuque, IA | |
| 1921 | W | Dubuque (IA) | 28 | William Penn (IA) | 0 | Dubuque, IA | |
| 1921 | W | Dubuque (IA) | 20 | Luther (IA) | 0 | Dubuque, IA | |
| 1921 | W | Dubuque (IA) | 70 | Palmer College of Chiropractic (IA) | 0 | Dubuque, IA | |
| 1921 | L | Dubuque (IA) | 0 | Des Moines (IA) | 7 | Dubuque, IA | |
| 1921 | L | Dubuque HS (IA) | 0 | Waterloo East HS (IA) | 21 | ? | |
| 1921 | T | Duke (NC) | 0 | Elon (NC) | 0 | Durham, NC | |
| 1921 | W | Duke (NC) | 7 | Emory & Henry (VA) | 0 | Emory, VA | |
| 1921 | T | Duke (NC) | 7 | New York (NY) | 7 | New York, NY | Ohio Field |
| 1921 | W | Duke (NC) | 6 | Randolph-Macon (VA) | 0 | Durham, NC | |
| 1921 | W | Duke (NC) | 68 | Wofford (SC) | 0 | Spartanburg, SC | |
| 1921 | W | Duke (NC) | 14 | Lynchburg (VA) | 13 | Durham, NC | |
| 1921 | W | Duke (NC) | 28 | Guilford (NC) | 0 | Durham, NC | |
| 1921 | L | Duke (NC) | 0 | William & Mary (VA) | 12 | Durham, NC | |
| 1921 | W | Duke (NC) | 17 | Wake Forest (NC) | 0 | Raleigh, NC | |
| 1921 | W | Duluth Cathedral HS (MN) | 42 | Ashland HS (WI) | 0 | ? | |
| 1921 | W | Duluth Cathedral HS (MN) | 20 | Duluth Cathedral HS Alumni (MN) | 0 | ? | |
| 1921 | W | Duluth Cathedral HS (MN) | 35 | Duluth Central HS (MN) | 0 | ? | |
| 1921 | L | Duluth Cathedral HS (MN) | 0 | Duluth Denfeld HS (MN) | 6 | ? | |
| 1921 | W | Duluth Cathedral HS (MN) | 62 | Morgan Park HS (MN) | 7 | ? | |
| 1921 | W | Duluth Cathedral HS (MN) | 53 | Spooner HS (WI) | 0 | ? | |
| 1921 | W | Duluth Cathedral HS (MN) | 19 | Superior Central HS (WI) | 14 | ? | |
| 1921 | W | Duluth Cathedral HS (MN) | 43 | Superior Dewey HS (WI) | 0 | ? | |
| 1921 | W | Duluth Cathedral HS (MN) | 19 | Superior HS (WI) | 14 | ? | |
| 1921 | L | Duluth Cathedral HS Alumni (MN) | 0 | Duluth Cathedral HS (MN) | 20 | ? | |
| 1921 | L | Duluth Central HS (MN) | 0 | Duluth Cathedral HS (MN) | 35 | ? | |
| 1921 | L | Duluth Central HS (MN) | 6 | Duluth Denfeld HS (MN) | 27 | ? | |
| 1921 | L | Duluth Central HS (MN) | 0 | Superior HS (WI) | 43 | ? | |
| 1921 | W | Duluth Denfeld HS (MN) | 42 | Cloquet HS (MN) | 6 | ? | |
| 1921 | L | Duluth Denfeld HS (MN) | 0 | Coleraine HS (MN) | 6 | ? | |
| 1921 | W | Duluth Denfeld HS (MN) | 6 | Duluth Cathedral HS (MN) | 0 | ? | |
| 1921 | W | Duluth Denfeld HS (MN) | 27 | Duluth Central HS (MN) | 6 | ? | |
| 1921 | W | Duluth Denfeld HS (MN) | 99 | Morgan Park HS (MN) | 7 | ? | |
| 1921 | W | Duluth Denfeld HS (MN) | 48 | Superior Dewey HS (WI) | 0 | ? | |
| 1921 | L | Duluth Denfeld HS (MN) | 7 | Superior HS (WI) | 21 | ? | |
| 1921 | L | Duluth Denfeld HS (MN) | 7 | Virginia HS (MN) | 14 | ? | |
| 1921 | L | Dumont HS (NJ) | 0 | Spring Valley HS (NY) | 6 | ? | |
| 1921 | L | Dumont HS (NJ) | 0 | Spring Valley HS (NY) | 13 | ? | |
| 1921 | L | Dundee HS (IL) | 0 | Elgin HS (IL) | 60 | ? | |
| 1921 | L | Dundee HS (IL) | 0 | Mooseheart HS (IL) | 49 | ? | |
| 1921 | L | Dundee HS (MI) | 0 | Tecumseh HS (MI) | 47 | ? | |
| 1921 | L | Dunkirk HS (NY) | 0 | Tonawanda HS (NY) | 41 | ? | |
| 1921 | W | Dunwoody College of Tech. (MN) | 33 | DeLaSalle HS | 0 | ? | |
| 1921 | T | Dunwoody College of Tech. (MN) | 7 | Minneapolis North HS (MN) | 7 | ? | |
| 1921 | L | Dunwoody College of Tech. (MN) | 0 | Shattuck School (MN) | 3 | ? | |
| 1921 | W | Dunwoody College of Tech. (MN) | 54 | Winona HS (MN) | 0 | ? | |
| 1921 | L | Dunwoody College of Tech. (MN) | 0 | Wisconsin-Stout | 37 | Menomonie, WI | |
| 1921 | L | Duquesne (PA) | 0 | Canisius (NY) | 14 | Buffalo, NY | |
| 1921 | L | Duquesne (PA) | 0 | Geneva (PA) | 9 | Beaver Falls, PA | |
| 1921 | L | Duquesne (PA) | 0 | Grove City (PA) | 44 | Pittsburgh, PA | |
| 1921 | L | Duquesne (PA) | 0 | Thiel (PA) | 26 | Greenville, PA | |
| 1921 | T | Duquesne (PA) | 7 | Marietta (OH) | 7 | New Wilmington, PA | |
| 1921 | L | Duquesne HS (PA) | 0 | Aspinwall HS (PA) | 2 | ? | |
| 1921 | W | Duquesne HS (PA) | 33 | Braddock HS (PA) | 0 | ? | |
| 1921 | W | Duquesne HS (PA) | 21 | Clairton HS (PA) | 0 | ? | |
| 1921 | W | Duquesne HS (PA) | 7 | Homestead HS (PA) | 0 | ? | |
| 1921 | L | Duquesne HS (PA) | 0 | McKeesport HS (PA) | 14 | ? | |
| 1921 | L | Duquesne HS (PA) | 0 | Monessen HS (PA) | 20 | ? | |
| 1921 | W | Duquesne HS (PA) | 35 | Munhall HS (PA) | 0 | ? | |
| 1921 | W | Duquesne HS (PA) | 62 | West Newton HS (PA) | 0 | ? | |
| 1921 | L | Durant HS (MS) | 12 | Grenada HS (MS) | 34 | ? | |
| 1921 | L | Durfee School | 0 | Haverhill HS (MA) | 40 | ? | |
| 1921 | W | Durham HS (NC) | 14 | Chapel Hill HS (NC) | 0 | ? | |
| 1921 | W | Durham HS (NC) | 14 | Greensboro HS (NC) | 7 | ? | |
| 1921 | W | Durham HS (NC) | 13 | Guilford JV (NC) | 6 | ? | |
| 1921 | W | Durham HS (NC) | 79 | Henderson HS (NC) | 0 | ? | |
| 1921 | W | Durham HS (NC) | 34 | Henderson HS (NC) | 6 | ? | |
| 1921 | L | Durham HS (NC) | 7 | Newbern HS | 34 | ? | |
| 1921 | W | Durham HS (NC) | 31 | Oxford HS (NC) | 0 | ? | |
| 1921 | W | Durham HS (NC) | 7 | Oxford HS (NC) | 0 | ? | |
| 1921 | W | Durham HS (NC) | 20 | Raleigh HS (NC) | 0 | ? | |
| 1921 | W | Durham HS (NC) | 41 | Raleigh HS (NC) | 0 | ? | |
| 1921 | L | Earlham (IN) | 7 | Butler (IN) | 33 | Indianapolis, IN | |
| 1921 | W | Earlham (IN) | 7 | Franklin (IN) | 0 | Richmond, IN | |
| 1921 | L | Earlham (IN) | 7 | Western Michigan | 42 | Kalamazoo, MI | |
| 1921 | W | Earlham (IN) | 14 | Hanover (IN) | 7 | Hanover, IN | |
| 1921 | T | Earlham (IN) | 14 | Dayton (OH) | 14 | Richmond, IN | |
| 1921 | L | Earlham (IN) | 0 | Wilmington (OH) | 6 | Richmond, IN | |
| 1921 | L | Earlham (IN) | 7 | Muskingum (OH) | 9 | Richmond, IN | |
| 1921 | L | East Bank HS (WV) | 0 | Charleston HS (WV) | 20 | ? | |
| 1921 | W | East Bank HS (WV) | 14 | Hinton HS (WV) | 7 | ? | |
| 1921 | L | East Bank HS (WV) | 0 | Spencer HS (WV) | 52 | ? | |
| 1921 | L | East Boston HS (MA) | 0 | Boston Hyde Park HS (MA) | 21 | ? | |
| 1921 | L | East Boston HS (MA) | 0 | Brighton HS (MA) | 14 | ? | |
| 1921 | L | East Central (OK) | 0 | Central Oklahoma | 104 | Edmond, OK | |
| 1921 | L | East Central (OK) | 0 | Kingfisher (OK) | 32 | Ada, OK | |
| 1921 | L | East Central (OK) | 14 | Oklahoma City (OK) | 59 | Oklahoma City, OK | |
| 1921 | L | East Central (OK) | 0 | Rolf National Guard (OK) | 7 | ? | |
| 1921 | L | East Central (OK) | 0 | Southeastern Oklahoma St. | 0 | ? | East Central Forfeits |
| 1921 | L | East Central (OK) | 0 | Southwestern Oklahoma St. | 1 | ? | East Central Forfeits |
| 1921 | L | East Central (OK) | 0 | Tulsa (OK) | 92 | Tulsa, OK | |
| 1921 | W | East Central (OK) | 26 | Eastern Oklahoma St. | 0 | Ada, OK | |
| 1921 | W | East Cleveland Shaw HS (OH) | 12 | Akron West HS (OH) | 10 | ? | |
| 1921 | W | East Cleveland Shaw HS (OH) | 34 | Ashtabula HS (OH) | 14 | ? | |
| 1921 | L | East Cleveland Shaw HS (OH) | 0 | Cleveland East HS (OH) | 7 | ? | |
| 1921 | L | East Cleveland Shaw HS (OH) | 7 | Cleveland East Tech HS (OH) | 37 | ? | |
| 1921 | W | East Cleveland Shaw HS (OH) | 21 | Cleveland Heights HS (OH) | 0 | ? | |
| 1921 | W | East Cleveland Shaw HS (OH) | 7 | Cleveland University School (OH) | 0 | ? | |
| 1921 | W | East Cleveland Shaw HS (OH) | 17 | Lakewood HS (OH) | 6 | ? | |
| 1921 | W | East Cleveland Shaw HS (OH) | 20 | Warren HS (OH) | 13 | ? | |
| 1921 | W | East Cleveland Shaw HS (OH) | 6 | Youngstown Rayen HS (OH) | 0 | ? | |
| 1921 | W | East Grand Forks HS (MN) | 12 | Crookston HS (MN) | 6 | ? | |
| 1921 | W | East Grand Forks HS (MN) | 26 | Stephen HS (MN) | 6 | ? | |
| 1921 | L | East Grand Forks HS (MN) | 0 | Thief River Falls HS (MN) | 13 | ? | |
| 1921 | L | East Greenwich Academy (RI) | 0 | Moses Brown School (RI) | 27 | ? | |
| 1921 | L | East Greenwich Academy (RI) | 0 | Providence (RI) | 28 | East Greenwich, RI | |
| 1921 | L | East Lansing HS (MI) | 0 | Marshall HS (MI) | 42 | ? | |
| 1921 | L | East Liverpool HS (OH) | 16 | Follansbee HS (WV) | 20 | ? | |
| 1921 | W | East Orange HS (NJ) | 28 | Jersey City Dickinson HS (NJ) | 0 | ? | |
| 1921 | W | East Orange HS (NJ) | 6 | Lawrenceville School (NJ) | 0 | ? | |
| 1921 | W | East Orange HS (NJ) | 26 | Montclair HS (NJ) | 21 | ? | |
| 1921 | L | East Orange HS (NJ) | 7 | Montclair Military Academy (NJ) | 19 | ? | |
| 1921 | W | East Orange HS (NJ) | 20 | Neptune HS (NJ) | 0 | ? | |
| 1921 | W | East Orange HS (NJ) | 14 | Newark Barringer HS (NJ) | 6 | ? | |
| 1921 | W | East Orange HS (NJ) | 20 | South Orange Columbia HS (NJ) | 6 | ? | |
| 1921 | T | East Orange HS (NJ) | 7 | Trenton HS (NJ) | 7 | ? | |
| 1921 | L | East Palestine HS (OH) | 6 | Monaca HS (PA) | 7 | ? | |
| 1921 | L | East Saint Louis Lincoln HS (IL) | 2 | Lane (TN) | 20 | ? | |
| 1921 | T | East Stroudsburg (PA) | 7 | Bethlehem Prep School (PA) | 7 | ? | |
| 1921 | L | East Stroudsburg (PA) | 7 | Lafayette Freshmen (PA) | 18 | ? | |
| 1921 | L | East Stroudsburg (PA) | 2 | Lehigh B Team (PA) | 6 | ? | |
| 1921 | W | East Stroudsburg (PA) | 14 | Scranton (PA) | 0 | ? | |
| 1921 | L | East Stroudsburg (PA) | 0 | Mansfield (PA) | 40 | Mansfield, PA | Smythe Field |
| 1921 | L | East Tennessee St. | 0 | Carson-Newman (TN) | 46 | ? | |
| 1921 | L | East Tennessee St. | 0 | Eastern Kentucky | 30 | ? | |
| 1921 | W | East Tennessee St. | 14 | Johnson City All-Stars (TN) | 7 | ? | |
| 1921 | L | East Tennessee St. | 0 | King College (TN) | 35 | Johnson City, TN | |
| 1921 | W | East Tennessee St. | 12 | Milligan (TN) | 7 | ? | |
| 1921 | L | East Tennessee St. | 0 | Murphy College (TN) | 35 | ? | |
| 1921 | W | East Tennessee St. | 20 | Tusculum (TN) | 0 | ? | |
| 1921 | W | East Tennessee St. | 42 | Washington College Academy (TN) | 0 | ? | |
| 1921 | L | East Tennessee St. | 7 | King College (TN) | 42 | Bristol, TN | |
| 1921 | W | Eastern HS | 14 | Bordentown Military Institute (NJ) | 0 | ? | |
| 1921 | W | Eastern Illinois | 59 | Blackburn (IL) | 6 | Charleston, IL | |
| 1921 | L | Eastern Illinois | 3 | Illinois Wesleyan | 74 | Bloomington, IL | |
| 1921 | L | Eastern Illinois | 6 | Lincoln College (IL) | 14 | Charleston, IL | |
| 1921 | W | Eastern Illinois | 28 | Rose-Hulman Tech (IN) | 0 | Charleston, IL | |
| 1921 | L | Eastern Illinois | 3 | Shurtleff (IL) | 6 | Charleston, IL | |
| 1921 | L | Eastern Illinois | 0 | Southern Illinois | 2 | Carbondale, IL | |
| 1921 | L | Eastern Illinois | 3 | Illinois St. | 42 | Normal, IL | |
| 1921 | T | Eastern Illinois | 0 | Rose-Hulman Tech (IN) | 0 | Charleston, IL | |
| 1921 | L | Eastern Kentucky | 0 | Cumberland (KY) | 33 | Williamsburg, KY | |
| 1921 | W | Eastern Kentucky | 30 | East Tennessee St. | 0 | ? | |
| 1921 | L | Eastern Kentucky | 0 | Kentucky JV | 20 | Richmond, KY | |
| 1921 | T | Eastern Kentucky | 0 | Kentucky Wesleyan | 0 | Richmond, KY | |
| 1921 | W | Eastern Kentucky | 7 | Paint Lick Military Prep School (KY) | 0 | Richmond, KY | |
| 1921 | L | Eastern Kentucky | 0 | Western Kentucky | 21 | Bowling Green, KY | |
| 1921 | L | Eastern Michigan | 14 | Albion (MI) | 27 | Ypsilanti, MI | |
| 1921 | L | Eastern Michigan | 0 | Alma (MI) | 7 | Ypsilanti, MI | |
| 1921 | W | Eastern Michigan | 7 | Central Michigan | 6 | Mount Pleasant, MI | |
| 1921 | L | Eastern Michigan | 0 | Wayne St. (MI) | 3 | Detroit, MI | |
| 1921 | W | Eastern Michigan | 48 | Assumption College (ON) | 0 | Ypsilanti, MI | |
| 1921 | W | Eastern Michigan | 13 | Hillsdale (MI) | 7 | Hillsdale, MI | |
| 1921 | L | Eastern Oklahoma St. | 0 | East Central (OK) | 26 | Ada, OK | |
| 1921 | L | Eastern Oklahoma St. | 0 | Arkansas Tech | 95 | Russellville, AR | |
| 1921 | L | Eastern Oklahoma St. | 0 | Pittsburg St. (KS) | 40 | Pittsburg, KS | |
| 1921 | L | Eastern Washington | 0 | Central Washington | 6 | Ellensburg, WA | |
| 1921 | W | Eastern Washington | 52 | Spokane College (WA) | 0 | Spokane, WA | |
| 1921 | W | Eastern Washington | 48 | Spokane University (WA) | 0 | Cheney, WA | |
| 1921 | L | Eastern Washington | 0 | Idaho Freshmen | 34 | Moscow, ID | |
| 1921 | L | Eastern Washington | 0 | Washington St. Freshmen | 28 | Cheney, WA | |
| 1921 | W | Eastern Washington | 21 | Whitworth (WA) | 2 | Cheney, WA | |
| 1921 | L | Eastman Business College (NY) | 0 | Middletown HS (NY) | 18 | ? | |
| 1921 | W | Eastman Business College (NY) | 6 | Pawling School (NY) | 3 | ? | |
| 1921 | L | Eastman Business College (NY) | 0 | Peekskill Military Academy (NY) | 6 | ? | |
| 1921 | L | Easton HS (PA) | 13 | Allentown HS (PA) | 14 | ? | |
| 1921 | W | Easton HS (PA) | 14 | Bordentown Military Institute (NJ) | 0 | ? | |
| 1921 | W | Easton HS (PA) | 56 | Lansford HS (PA) | 7 | ? | |
| 1921 | W | Easton HS (PA) | 7 | Lebanon HS (PA) | 0 | ? | |
| 1921 | W | Easton HS (PA) | 44 | Phillipsburg HS (NJ) | 7 | ? | |
| 1921 | W | Easton HS (PA) | 35 | Reading HS (PA) | 0 | ? | |
| 1921 | W | Easton HS (PA) | 27 | Scranton Central HS (PA) | 2 | ? | |
| 1921 | W | Easton HS (PA) | 68 | Wilson HS (PA) | 0 | ? | |
| 1921 | L | Eaton HS (CO) | 0 | Greeley HS (CO) | 7 | ? | |
| 1921 | W | Edgemont HS (SD) | 7 | Chadron HS (NE) | 0 | ? | |
| 1921 | W | Edgemont HS (SD) | 34 | Chadron HS (NE) | 0 | ? | |
| 1921 | W | Edgemont HS (SD) | 35 | Crawford HS (NE) | 33 | ? | |
| 1921 | W | Edgemont HS (SD) | 12 | Hot Springs HS (SD) | 0 | ? | |
| 1921 | W | Edgemont HS (SD) | 35 | Newcastle HS (WY) | 14 | ? | |
| 1921 | W | Edgemont HS (SD) | 21 | Newcastle HS (WY) | 0 | ? | |
| 1921 | W | Edgemont HS (SD) | 31 | Newcastle HS (WY) | 0 | ? | |
| 1921 | T | Edgewood HS (PA) | 0 | Ben Avon HS (PA) | 0 | ? | |
| 1921 | L | Edison Drafting School | 14 | Gloversville HS (NY) | 34 | ? | |
| 1921 | W | Edmonds HS (WA) | 24 | Granite Falls HS (WA) | 0 | ? | |
| 1921 | W | Edmonton Eskimos (AB) | 41 | Alberta (AB) | 0 | Edmonton, AB (Canada) | |
| 1921 | W | Edmonton Eskimos (AB) | 35 | Alberta (AB) | 3 | Edmonton, AB (Canada) | Diamond Park |
| 1921 | W | El Centro Central HS (CA) | 27 | Brawley HS (CA) | 8 | ? | |
| 1921 | W | El Centro Central HS (CA) | 37 | Brawley HS (CA) | 0 | ? | |
| 1921 | W | El Centro Central HS (CA) | 53 | Calexico HS (CA) | 0 | ? | |
| 1921 | W | El Centro Central HS (CA) | 35 | Calexico HS (CA) | 0 | ? | |
| 1921 | W | El Centro Central HS (CA) | 6 | El Centro Central HS Alumni (CA) | 0 | ? | |
| 1921 | W | El Centro Central HS (CA) | 43 | Holtville HS (CA) | 0 | ? | |
| 1921 | W | El Centro Central HS (CA) | 20 | Holtville HS (CA) | 6 | ? | |
| 1921 | L | El Centro Central HS Alumni (CA) | 0 | El Centro Central HS (CA) | 6 | ? | |
| 1921 | L | El Monte HS (CA) | 0 | Chaffee HS (CA) | 47 | ? | |
| 1921 | L | El Paso Com. Cl. (TX) | 0 | El Paso HS (TX) | 48 | ? | |
| 1921 | T | El Paso HS (TX) | 0 | 1st Cavalry Division | 0 | ? | |
| 1921 | W | El Paso HS (TX) | 65 | Albuquerque HS (NM) | 0 | ? | |
| 1921 | L | El Paso HS (TX) | 0 | Columbus Club | 21 | ? | |
| 1921 | W | El Paso HS (TX) | 14 | Deming HS (NM) | 0 | ? | |
| 1921 | W | El Paso HS (TX) | 48 | El Paso Com. Cl. (TX) | 0 | ? | |
| 1921 | T | El Paso HS (TX) | 0 | Las Cruces HS (NM) | 0 | ? | |
| 1921 | L | El Paso HS (TX) | 7 | Phoenix HS (AZ) | 27 | ? | |
| 1921 | L | El Paso HS (TX) | 0 | New Mexico St. | 46 | Las Cruces, NM | Exhibition Game |
| 1921 | L | El Reno HS (OK) | 7 | Oklahoma City HS (OK) | 21 | ? | |
| 1921 | L | Eldorado HS (IL) | 0 | Murphysboro HS (IL) | 65 | ? | |
| 1921 | L | Elgin Academy (IL) | 0 | Marquette Academy (WI) | 39 | ? | |
| 1921 | L | Elgin Academy (IL) | 0 | Northern Illinois | 21 | Elgin, IL | |
| 1921 | L | Elgin HS (IL) | 0 | Ansonia HS (CT) | 13 | ? | |
| 1921 | W | Elgin HS (IL) | 7 | Aurora East HS (IL) | 0 | ? | |
| 1921 | W | Elgin HS (IL) | 10 | Aurora West HS (IL) | 7 | ? | |
| 1921 | T | Elgin HS (IL) | 7 | Chicago Hyde Park HS (IL) | 7 | ? | |
| 1921 | W | Elgin HS (IL) | 35 | DeKalb HS (IL) | 0 | ? | |
| 1921 | W | Elgin HS (IL) | 60 | Dundee HS (IL) | 0 | ? | |
| 1921 | W | Elgin HS (IL) | 35 | Freeport HS (IL) | 6 | ? | |
| 1921 | W | Elgin HS (IL) | 52 | Joliet HS (IL) | 0 | ? | |
| 1921 | W | Elgin HS (IL) | 35 | Macomb HS (IL) | 7 | ? | |
| 1921 | W | Elgin HS (IL) | 6 | Rockford HS (IL) | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 33 | All-Stars | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 28 | Bardstown HS (KY) | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 53 | Bloomfield HS (KY) | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 42 | Franklin HS (KY) | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 29 | Glasgow HS (KY) | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 65 | Glasgow HS (KY) | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 45 | Jeffersonville HS (IN) | 0 | ? | |
| 1921 | L | Elizabethtown HS (KY) | 3 | Louisville HS (KY) | 19 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 19 | Louisville Saint Xavier HS (KY) | 0 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 34 | New Albany HS (IN) | 7 | ? | |
| 1921 | W | Elizabethtown HS (KY) | 28 | Pineville HS (KY) | 14 | ? | |
| 1921 | L | Elizabethville HS (PA) | 0 | Harrisburg Academy (PA) | 21 | ? | |
| 1921 | L | Elk River HS (MN) | 7 | Anoka HS (MN) | 26 | ? | |
| 1921 | L | Elk River HS (MN) | 0 | Milaca HS (MN) | 6 | ? | |
| 1921 | L | Elkhart HS (IN) | 0 | Gary Froebel HS (IN) | 53 | ? | |
| 1921 | L | Elkhart HS (KS) | 0 | Oklahoma Panhandle St. | 6 | ? | Oklahoma Panhandle St. won - score unknown |
| 1921 | W | Elkhart HS (KS) | 6 | Oklahoma Panhandle St. | 0 | ? | Elkhart HS won - score unknown |
| 1921 | W | Elkins HS (WV) | 48 | Allegheny Co. | 0 | ? | |
| 1921 | W | Elkins HS (WV) | 34 | Belington HS (WV) | 0 | ? | |
| 1921 | W | Elkins HS (WV) | 48 | Belington HS (WV) | 7 | ? | |
| 1921 | W | Elkins HS (WV) | 18 | Charleston HS (WV) | 6 | ? | |
| 1921 | W | Elkins HS (WV) | 25 | Clarksburg Victory HS (WV) | 0 | ? | |
| 1921 | W | Elkins HS (WV) | 12 | Elkins HS Alumni (WV) | 0 | ? | |
| 1921 | W | Elkins HS (WV) | 7 | Fairmont HS (WV) | 0 | ? | |
| 1921 | W | Elkins HS (WV) | 14 | Grafton HS (WV) | 0 | ? | |
| 1921 | W | Elkins HS (WV) | 32 | Mannington HS (WV) | 0 | ? | |
| 1921 | L | Elkins HS (WV) | 0 | Parkersburg HS (WV) | 61 | ? | |
| 1921 | W | Elkins HS (WV) | 20 | Parsons HS (WV) | 0 | ? | |
| 1921 | L | Elkins HS (WV) | 14 | Weston HS (WV) | 17 | ? | |
| 1921 | L | Elkins HS Alumni (WV) | 0 | Elkins HS (WV) | 12 | ? | |
| 1921 | W | Elkton HS (MD) | 7 | Newark HS (DE) | 0 | ? | |
| 1921 | L | Elkton HS (MD) | 0 | Newark HS (DE) | 39 | ? | |
| 1921 | L | Ellicott City HS (MD) | 0 | Rock Hill College (MD) | 34 | ? | |
| 1921 | L | Ellington AFB (TX) | 0 | Sam Houston St. (TX) | 69 | Huntsville, TX | |
| 1921 | L | Ellisville HS (MS) | 0 | Southern Mississippi | 20 | Ellisville, MS | |
| 1921 | L | Ellisville Jones County HS (MS) | 0 | Southern Mississippi | 37 | Hattiesburg, MS | |
| 1921 | L | Ellsworth CC (IA) | 0 | Buena Vista (IA) | 14 | Storm Lake, IA | |
| 1921 | L | Ellsworth CC (IA) | 0 | Northern Iowa | 56 | Cedar Falls, IA | |
| 1921 | L | Ellsworth CC (IA) | 0 | Still College (IA) | 7 | Iowa Falls, IA | |
| 1921 | L | Ellsworth CC (IA) | 0 | Upper Iowa | 49 | Fayette, IA | |
| 1921 | W | Ellsworth CC (IA) | 28 | Westmar (IA) | 7 | Iowa Falls, IA | |
| 1921 | L | Ellsworth CC (IA) | 0 | Loras (IA) | 76 | Iowa Falls, IA | |
| 1921 | L | Ellsworth CC (IA) | 0 | Central (IA) | 13 | Pella, IA | |
| 1921 | L | Ellwood City HS (PA) | 7 | Rochester HS (PA) | 31 | ? | |
| 1921 | T | Ellwood HS (PA) | 0 | New Castle HS (PA) | 0 | ? | |
| 1921 | L | Elmhurst (IL) | 6 | Wheaton (IL) | 40 | Elmhurst, IL | |
| 1921 | L | Elmhurst (IL) | 10 | Northern Illinois | 91 | DeKalb, IL | |
| 1921 | L | Elmhurst (IL) | 0 | Wheaton (IL) | 20 | Wheaton, IL | |
| 1921 | L | Elmira Free Academy (NY) | 0 | Binghamton Central HS (NY) | 49 | ? | |
| 1921 | W | Elmira HS (NY) | 7 | Buffalo Technical HS (NY) | 0 | ? | |
| 1921 | W | Elon (NC) | 19 | Chapel Hill HS (NC) | 9 | Elon College, NC | |
| 1921 | L | Elon (NC) | 0 | Davidson (NC) | 47 | Davidson, NC | |
| 1921 | T | Elon (NC) | 0 | Duke (NC) | 0 | Durham, NC | |
| 1921 | W | Elon (NC) | 7 | Guilford (NC) | 0 | Elon College, NC | |
| 1921 | L | Elon (NC) | 7 | Wofford (SC) | 20 | Spartanburg, SC | |
| 1921 | W | Elon (NC) | 39 | Lenoir-Rhyne (NC) | 0 | Elon College, NC | |
| 1921 | L | Elon (NC) | 0 | Hampden-Sydney (VA) | 7 | Hampden-Sydney, VA | |
| 1921 | L | Elon (NC) | 7 | Lynchburg (VA) | 15 | Lynchburg, VA | |
| 1921 | T | Elon (NC) | 0 | Guilford (NC) | 0 | Greensboro, NC | |
| 1921 | L | Elwood HS (IN) | 0 | Indianapolis Shortridge HS (IN) | 7 | ? | |
| 1921 | W | Ely HS (MN) | 6 | Aurora HS (MN) | 0 | ? | |
| 1921 | L | Elyria HS (OH) | 7 | Dayton Steele HS (OH) | 83 | ? | |
| 1921 | L | Elyria HS (OH) | 0 | Sandusky HS (OH) | 16 | ? | |
| 1921 | T | Emmetsburg Saint Mary's HS (IA) | 13 | Windom HS (MN) | 13 | ? | |
| 1921 | W | Emory & Henry (VA) | 9 | Carson-Newman (TN) | 7 | ? | |
| 1921 | L | Emory & Henry (VA) | 0 | Duke (NC) | 7 | Emory, VA | |
| 1921 | W | Emory & Henry (VA) | 19 | King College (TN) | 7 | Bristol, TN | |
| 1921 | W | Emory & Henry (VA) | 21 | Lynchburg (VA) | 6 | Emory, VA | |
| 1921 | L | Emory & Henry (VA) | 7 | Maryville (TN) | 34 | Maryville, TN | |
| 1921 | L | Emory & Henry (VA) | 0 | Tennessee | 27 | Knoxville, TN | |
| 1921 | W | Emory & Henry (VA) | 31 | Milligan (TN) | 6 | Emory, VA | |
| 1921 | L | Emory & Henry (VA) | 14 | Roanoke (VA) | 33 | Salem, VA | |
| 1921 | L | Emory & Henry (VA) | 0 | Washington & Lee (VA) | 27 | Lexington, VA | |
| 1921 | T | Emory & Henry (VA) | 0 | Tusculum (TN) | 0 | Bristol, TN | Score unknown |
| 1921 | W | Emporia St. (KS) | 42 | Friends (KS) | 0 | Emporia, KS | |
| 1921 | W | Emporia St. (KS) | 27 | Pittsburg St. (KS) | 7 | Pittsburg, KS | |
| 1921 | W | Emporia St. (KS) | 14 | Saint Mary's (KS) | 0 | ? | |
| 1921 | W | Emporia St. (KS) | 61 | Southwestern (KS) | 0 | Emporia, KS | |
| 1921 | W | Emporia St. (KS) | 13 | Washburn (KS) | 10 | Topeka, KS | |
| 1921 | W | Emporia St. (KS) | 26 | Ottawa (KS) | 0 | Ottawa, KS | |
| 1921 | W | Emporia St. (KS) | 13 | Baker (KS) | 7 | Emporia, KS | |
| 1921 | T | Endicott Union HS (NY) | 0 | Albany HS (NY) | 0 | ? | |
| 1921 | L | Endicott Union HS (NY) | 0 | Binghamton Central HS (NY) | 10 | ? | |
| 1921 | W | Endicott Union HS (NY) | 42 | Cortland HS (NY) | 0 | ? | |
| 1921 | W | Endicott Union HS (NY) | 7 | Geneva HS (NY) | 0 | ? | |
| 1921 | W | Endicott Union HS (NY) | 7 | Mansfield JV (PA) | 0 | ? | |
| 1921 | W | Endicott Union HS (NY) | 19 | Norwich HS (NY) | 6 | ? | |
| 1921 | W | Endicott Union HS (NY) | 48 | Scranton (PA) | 0 | ? | |
| 1921 | W | Endicott Union HS (NY) | 30 | Syracuse Vocational School (NY) | 0 | ? | |
| 1921 | W | Endicott Union HS (NY) | 49 | Walton HS (NY) | 0 | ? | |
| 1921 | L | Englewood AC (MT) | 0 | Montana Tech | 28 | ? | |
| 1921 | L | Englewood HS (CO) | 0 | Canon City HS (CO) | 56 | ? | |
| 1921 | L | Englewood HS (NJ) | 0 | Cliffside Park HS (NJ) | 34 | ? | |
| 1921 | L | Englewood HS (NJ) | 0 | Hackensack HS (NJ) | 21 | ? | |
| 1921 | W | Englewood HS (NJ) | 13 | Leonia HS (NJ) | 0 | ? | |
| 1921 | W | Englewood HS (NJ) | 27 | Nyack HS (NY) | 6 | ? | |
| 1921 | W | Englewood HS (NJ) | 7 | Passaic HS (NJ) | 3 | ? | |
| 1921 | L | Englewood HS (NJ) | 0 | Ridgefield Park HS (NJ) | 34 | ? | |
| 1921 | W | Englewood HS (NJ) | 3 | Ridgewood HS (NJ) | 0 | ? | |
| 1921 | L | Englewood HS (NJ) | 7 | Rutherford HS (NJ) | 35 | ? | |
| 1921 | W | Enid HS (OK) | 7 | Oklahoma City HS (OK) | 0 | ? | |
| 1921 | L | Enid HS (OK) | 0 | Sapulpa HS (OK) | 14 | ? | |
| 1921 | W | Enterprise HS (AL) | 33 | Troy (AL) | 0 | Troy, AL | |
| 1921 | L | Enterprise HS (OR) | 3 | Pendleton HS (OR) | 42 | ? | |
| 1921 | W | Episcopal Academy (PA) | 36 | Chestnut Hill Academy (PA) | 7 | ? | |
| 1921 | W | Episcopal Academy (PA) | 35 | Friends Central School (PA) | 0 | ? | |
| 1921 | T | Episcopal Academy (PA) | 0 | Germantown Academy (PA) | 0 | ? | |
| 1921 | L | Episcopal Academy (PA) | 2 | Haverford College Grammer School (PA) | 7 | ? | |
| 1921 | L | Episcopal Academy (PA) | 0 | Penn Charter School (PA) | 12 | ? | |
| 1921 | W | Episcopal Academy (PA) | 34 | Saint Luke's School (PA) | 0 | ? | |
| 1921 | W | Episcopal Academy (PA) | 27 | Swarthmore HS (PA) | 0 | ? | |
| 1921 | L | Erie Central HS (PA) | 14 | Buffalo Masten Park HS (NY) | 27 | ? | |
| 1921 | L | Erie Central HS (PA) | 0 | Lakewood HS (OH) | 33 | ? | |
| 1921 | L | Erie Central HS (PA) | 0 | Washington HS (PA) | 32 | ? | |
| 1921 | W | Erie HS (PA) | 27 | Tonawanda HS (NY) | 16 | ? | |
| 1921 | W | Erskine (SC) | 13 | Citadel (SC) | 6 | Due West, SC | |
| 1921 | W | Erskine (SC) | 13 | Clemson (SC) | 0 | Clemson, SC | |
| 1921 | W | Erskine (SC) | 74 | College of Charleston (SC) | 0 | Due West, SC | |
| 1921 | L | Erskine (SC) | 7 | Furman (SC) | 42 | Greenville, SC | |
| 1921 | W | Erskine (SC) | 21 | Presbyterian (SC) | 7 | Clinton, SC | |
| 1921 | L | Erskine (SC) | 7 | South Carolina | 13 | Columbia, SC | |
| 1921 | W | Erskine (SC) | 19 | Wofford (SC) | 6 | Spartanburg, SC | |
| 1921 | W | Erskine (SC) | 18 | Newberry (SC) | 13 | Due West, SC | |
| 1921 | L | Essex County Agriculture School (MA) | 7 | Amesbury HS (MA) | 27 | ? | |
| 1921 | W | Essex County Agriculture School (MA) | 19 | Danvers HS (MA) | 0 | ? | |
| 1921 | W | Essex County Agriculture School (MA) | 51 | Johnson HS | 0 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Methuen HS (MA) | 9 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Newburyport HS (MA) | 7 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 6 | Norfolk Agri. | 21 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Pinkerton Academy | 7 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Salem HS (MA) | 13 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 7 | Amesbury HS (MA) | 27 | ? | |
| 1921 | W | Essex County Agriculture School (MA) | 19 | Danvers HS (MA) | 0 | ? | |
| 1921 | W | Essex County Agriculture School (MA) | 51 | Johnson HS | 0 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Methuen HS (MA) | 9 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Newburyport HS (MA) | 7 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 6 | Norfolk Agri. | 21 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Pinkerton Academy | 7 | ? | |
| 1921 | L | Essex County Agriculture School (MA) | 0 | Salem HS (MA) | 13 | ? | |
| 1921 | L | Eureka (IL) | 0 | Bradley (IL) | 3 | Eureka, IL | |
| 1921 | W | Eureka (IL) | 17 | Carthage (WI) | 12 | Carthage, IL | |
| 1921 | W | Eureka (IL) | 35 | Illinois Wesleyan | 0 | Eureka, IL | |
| 1921 | W | Eureka (IL) | 19 | Monmouth (IL) | 0 | Monmouth, IL | |
| 1921 | W | Eureka (IL) | 37 | Hedding (IL) | 0 | Abingdon, IL | |
| 1921 | W | Eureka (IL) | 8 | Illinois St. | 0 | Eureka, IL | |
| 1921 | L | Eureka (IL) | 0 | Illinois College | 14 | Jacksonville, IL | |
| 1921 | L | Eureka HS (CA) | 10 | Santa Rosa HS (CA) | 54 | ? | |
| 1921 | T | Evander Childs HS (NY) | 6 | Brooklyn Boys HS (NY) | 6 | ? | |
| 1921 | T | Evander Childs HS (NY) | 0 | City College of New York Freshmen | 0 | ? | |
| 1921 | L | Evander Childs HS (NY) | 0 | Cliffside Park HS (NJ) | 21 | ? | |
| 1921 | L | Evander Childs HS (NY) | 0 | New Utrecht HS (NY) | 7 | ? | |
| 1921 | W | Evander Childs HS (NY) | 12 | New York Columbia Grammar HS (NY) | 0 | ? | |
| 1921 | L | Evander Childs HS (NY) | 0 | New York HS of Commerce (NY) | 13 | ? | |
| 1921 | W | Evander Childs HS (NY) | 20 | New York Morris HS (NY) | 0 | ? | |
| 1921 | L | Evander Childs HS (NY) | 0 | Stuyvesant HS (NY) | 14 | ? | |
| 1921 | L | Evans City HS (PA) | 0 | New Castle HS (PA) | 14 | ? | |
| 1921 | W | Evanston HS (IL) | 7 | Chicago Nicholas Senn HS (IL) | 6 | ? | |
| 1921 | L | Evanston HS (IL) | 3 | Deerfield Shields HS (IL) | 34 | ? | |
| 1921 | L | Evanston HS (IL) | 0 | La Grange HS (IL) | 2 | ? | |
| 1921 | W | Evanston HS (IL) | 34 | Thornton HS (IL) | 0 | ? | |
| 1921 | W | Evanston HS (WY) | 14 | Westminster College (UT) | 0 | ? | |
| 1921 | L | Eveleth JC (MN) | 7 | Wisconsin-Superior | 57 | ? | |
| 1921 | T | Everett HS (MA) | 6 | Brockton HS (MA) | 6 | ? | |
| 1921 | W | Everett HS (MA) | 7 | Brookline HS (MA) | 0 | ? | |
| 1921 | T | Everett HS (MA) | 0 | Cambridge Latin & HS (MA) | 0 | ? | |
| 1921 | L | Everett HS (MA) | 7 | Malden HS (MA) | 14 | ? | |
| 1921 | L | Everett HS (MA) | 0 | Medford HS (MA) | 7 | ? | |
| 1921 | L | Everett HS (MA) | 0 | Newton North HS (MA) | 10 | ? | |
| 1921 | L | Everett HS (MA) | 7 | Rindge Tech (MA) | 15 | ? | |
| 1921 | W | Everett HS (MA) | 6 | Somerville HS (MA) | 0 | ? | |
| 1921 | L | Everett HS (MA) | 7 | Worcester Commerce HS (MA) | 9 | ? | |
| 1921 | W | Everett HS (WA) | 13 | Everett HS Alumni (WA) | 7 | ? | |
| 1921 | W | Everett HS (WA) | 74 | Mount Vernon HS (WA) | 7 | ? | |
| 1921 | W | Everett HS (WA) | 14 | Portland (OR) | 10 | ? | |
| 1921 | W | Everett HS (WA) | 48 | Portland Washington HS (OR) | 7 | ? | |
| 1921 | W | Everett HS (WA) | 42 | Walla Walla HS (WA) | 0 | ? | |
| 1921 | T | Everett HS (WA) | 7 | Washington Freshmen | 7 | ? | |
| 1921 | W | Everett HS (WA) | 48 | Wenatchee HS (WA) | 7 | ? | |
| 1921 | L | Everett HS Alumni (WA) | 7 | Everett HS (WA) | 13 | ? | |
| 1921 | W | Fairfield HS (IA) | 14 | Keokuk HS (IA) | 0 | ? | |
| 1921 | L | Fairfield HS (NE) | 0 | Cambridge HS (NE) | 47 | ? | |
| 1921 | L | Fairhaven HS (MA) | 0 | Fall River Durfee HS (MA) | 17 | ? | |
| 1921 | L | Fairhaven HS (MA) | 6 | Norwood HS (MA) | 7 | ? | |
| 1921 | L | Fairmont East Side HS (WV) | 0 | Belington HS (WV) | 13 | ? | |
| 1921 | L | Fairmont East Side HS (WV) | 7 | Fairmont HS (WV) | 14 | ? | |
| 1921 | L | Fairmont East Side HS (WV) | 6 | Grafton HS (WV) | 28 | ? | |
| 1921 | L | Fairmont East Side HS (WV) | 0 | Mannington HS (WV) | 27 | ? | |
| 1921 | L | Fairmont East Side HS (WV) | 6 | Morgantown HS (WV) | 8 | ? | |
| 1921 | W | Fairmont East Side HS (WV) | 46 | Salem HS (OH) | 7 | ? | |
| 1921 | W | Fairmont East Side HS (WV) | 26 | Shinnston HS (WV) | 0 | ? | |
| 1921 | L | Fairmont East Side HS (WV) | 7 | West Union HS (WV) | 21 | ? | |
| 1921 | L | Fairmont East Side HS (WV) | 7 | Weston HS (WV) | 47 | ? | |
| 1921 | L | Fairmont HS (WV) | 0 | Buckhannon HS (WV) | 27 | ? | |
| 1921 | L | Fairmont HS (WV) | 0 | Clarksburg HS (WV) | 26 | ? | |
| 1921 | W | Fairmont HS (WV) | 7 | Clarksburg Victory HS (WV) | 0 | ? | |
| 1921 | L | Fairmont HS (WV) | 0 | Elkins HS (WV) | 7 | ? | |
| 1921 | W | Fairmont HS (WV) | 14 | Fairmont East Side HS (WV) | 7 | ? | |
| 1921 | L | Fairmont HS (WV) | 0 | Grafton HS (WV) | 14 | ? | |
| 1921 | W | Fairmont HS (WV) | 7 | Mannington HS (WV) | 0 | ? | |
| 1921 | W | Fairmont HS (WV) | 7 | Morgantown HS (WV) | 0 | ? | |
| 1921 | L | Fairmont HS (WV) | 7 | Morgantown HS (WV) | 19 | ? | |
| 1921 | L | Fairmont HS (WV) | 0 | Parkersburg HS (WV) | 41 | ? | |
| 1921 | L | Fairmont HS (WV) | 0 | Washington Irving HS (WV) | 26 | ? | |
| 1921 | T | Fairmont HS (WV) | 0 | Weston HS (WV) | 0 | ? | |
| 1921 | L | Fairmont St. (WV) | 0 | Bethany JV (WV) | 6 | ? | |
| 1921 | L | Fairmont St. (WV) | 0 | Broaddus College (WV) | 1 | Philippi, WV | Fairmont St. Forfeits |
| 1921 | W | Fairmont St. (WV) | 6 | Broaddus College (WV) | 0 | Fairmont, WV | |
| 1921 | L | Fairmont St. (WV) | 0 | Davis & Elkins (WV) | 21 | ? | |
| 1921 | L | Fairmont St. (WV) | 7 | Keyser Prep School (WV) | 21 | ? | |
| 1921 | L | Fairmont St. (WV) | 7 | Salem College (WV) | 42 | ? | |
| 1921 | W | Fairmont St. (WV) | 17 | Waynesburg (PA) | 14 | ? | |
| 1921 | L | Fairmont St. (WV) | 21 | West Virginia Freshmen | 35 | ? | |
| 1921 | L | Fall River Durfee HS (MA) | 0 | Brockton HS (MA) | 56 | ? | |
| 1921 | W | Fall River Durfee HS (MA) | 17 | Fairhaven HS (MA) | 0 | ? | |
| 1921 | L | Fall River Durfee HS (MA) | 9 | Haverhill Saint James HS (MA) | 40 | ? | |
| 1921 | T | Fall River Durfee HS (MA) | 0 | La Salle Prep | 0 | ? | |
| 1921 | L | Fall River Durfee HS (MA) | 0 | Mansfield HS (MA) | 13 | ? | |
| 1921 | W | Fall River Durfee HS (MA) | 28 | Mansfield HS (MA) | 0 | ? | |
| 1921 | L | Fall River Durfee HS (MA) | 13 | New Bedford HS (MA) | 19 | ? | |
| 1921 | W | Fall River Durfee HS (MA) | 13 | New Bedford HS (MA) | 0 | ? | |
| 1921 | W | Fall River Durfee HS (MA) | 13 | Pawtucket HS (RI) | 6 | ? | |
| 1921 | W | Fall River Durfee HS (MA) | 7 | Taber Academy | 0 | ? | |
| 1921 | W | Fall River Durfee HS (MA) | 21 | Taunton HS (MA) | 0 | ? | |
| 1921 | W | Fall River Durfee HS (MA) | 34 | Taunton HS (MA) | 0 | ? | |
| 1921 | T | Fargo College (ND) | 7 | Concordia-Moorhead (MN) | 7 | Fargo, ND | |
| 1921 | W | Fargo College (ND) | 13 | Jamestown (ND) | 0 | Fargo, ND | |
| 1921 | L | Fargo College (ND) | 0 | North Dakota | 40 | Fargo, ND | |
| 1921 | W | Fargo College (ND) | 19 | Moorhead St. (MN) | 9 | Moorhead, MN | |
| 1921 | L | Fargo College (ND) | 7 | North Dakota St. | 19 | Fargo, ND | |
| 1921 | T | Faribault HS (MN) | 7 | Albert Lea HS (MN) | 7 | ? | |
| 1921 | W | Faribault HS (MN) | 26 | Austin HS (MN) | 6 | ? | |
| 1921 | W | Faribault HS (MN) | 31 | Kenyon HS (MN) | 0 | ? | |
| 1921 | W | Faribault HS (MN) | 35 | Northfield HS (MN) | 0 | ? | |
| 1921 | W | Faribault HS (MN) | 7 | Owatonna HS (MN) | 0 | ? | |
| 1921 | L | Faribault HS (MN) | 0 | Rochester HS (MN) | 13 | ? | |
| 1921 | L | Farmington All-Stars (MO) | 0 | Marvin College (MO) | 2 | ? | |
| 1921 | L | Farmington HS (MN) | 7 | New Prague HS (MN) | 25 | ? | |
| 1921 | L | Farmington HS (MN) | 7 | Stillwater HS (MN) | 20 | ? | |
| 1921 | L | Farrell HS (PA) | 0 | Warren HS (OH) | 34 | ? | |
| 1921 | L | Fayetteville HS (AR) | 0 | Rogers HS (AR) | 24 | ? | |
| 1921 | L | Fayetteville HS (AR) | 0 | Van Buren HS (AR) | 27 | ? | |
| 1921 | T | Fayetteville HS (NC) | 0 | Chapel Hill HS (NC) | 0 | ? | |
| 1921 | L | Fayetteville HS (NC) | 0 | New Hanover HS (NC) | 7 | ? | |
| 1921 | W | Fayetteville HS (NC) | 21 | New Hanover HS (NC) | 0 | ? | |
| 1921 | W | Fayetteville HS (NC) | 13 | New Hanover HS (NC) | 0 | ? | |
| 1921 | W | Fayetteville HS (NC) | 48 | Rocky Mount HS (NC) | 0 | ? | |
| 1921 | L | Fenton HS (MI) | 0 | Flint Central HS (MI) | 58 | ? | |
| 1921 | W | Fergus County HS (MT) | 27 | Harlowton HS (MT) | 0 | ? | |
| 1921 | W | Fergus County HS (MT) | 70 | Harlowton HS (MT) | 0 | ? | |
| 1921 | L | Fergus Falls HS (MN) | 0 | Moorhead HS (MN) | 29 | ? | |
| 1921 | L | Fergus Falls HS (MN) | 0 | Wadena HS (MN) | 51 | ? | |
| 1921 | L | Ferris St. (MI) | 0 | Central Michigan | 60 | Big Rapids, MI | |
| 1921 | W | Ferris St. (MI) | 75 | Ludington Legion (MI) | 0 | Big Rapids, MI | |
| 1921 | L | Ferris St. (MI) | 0 | Traverse City HS (MI) | 24 | Traverse City, MI | |
| 1921 | L | Ferris St. (MI) | 0 | Western Michigan | 49 | Kalamazoo, MI | |
| 1921 | L | Ferris St. (MI) | 0 | Central Michigan | 7 | Big Rapids, MI | |
| 1921 | W | Ferris St. (MI) | 7 | Mount Pleasant HS (MI) | 0 | Big Rapids, MI | |
| 1921 | L | Ferris St. (MI) | 6 | Kalamazoo (MI) | 97 | Kalamazoo, MI | |
| 1921 | L | Findlay (OH) | 0 | Bowling Green (OH) | 151 | Bowling Green, OH | |
| 1921 | L | Findlay (OH) | 0 | Defiance (OH) | 119 | Findlay, OH | |
| 1921 | L | Findlay (OH) | 0 | Toledo (OH) | 46 | Findlay, OH | |
| 1921 | L | Findlay HS (OH) | 6 | Fostoria HS (OH) | 13 | ? | |
| 1921 | W | Findlay HS (OH) | 14 | Sandusky HS (OH) | 7 | ? | |
| 1921 | W | Fishburne Military School (VA) | 13 | Augusta Military Academy (VA) | 0 | ? | |
| 1921 | L | Fishburne Military School (VA) | 0 | Greenbrier Military Academy (WV) | 3 | ? | |
| 1921 | W | Fishburne Military School (VA) | 14 | Massanutten Military Academy (VA) | 7 | ? | |
| 1921 | W | Fishburne Military School (VA) | 28 | S.C.I. | 0 | ? | |
| 1921 | L | Fishburne Military School (VA) | 0 | Staunton Military Academy (VA) | 39 | ? | |
| 1921 | W | Fishburne Military School (VA) | 26 | V.S.B.D. | 13 | ? | |
| 1921 | W | Fishburne Military School (VA) | 7 | Washington & Lee Freshmen (VA) | 0 | ? | |
| 1921 | T | Fishburne Military School (VA) | 0 | Woodberry Forest School (VA) | 0 | ? | |
| 1921 | L | Fisk (TN) | 0 | Morehouse (GA) | 6 | ? | |
| 1921 | W | Fisk (TN) | 33 | Rust (MS) | 0 | ? | |
| 1921 | W | Fisk (TN) | 13 | Simmons (KY) | 7 | ? | |
| 1921 | W | Fisk (TN) | 7 | Tuskegee (AL) | 2 | ? | |
| 1921 | W | Fisk (TN) | 14 | Wilberforce (OH) | 0 | ? | |
| 1921 | W | Fitchburg HS (MA) | 14 | Boston College HS (MA) | 7 | ? | |
| 1921 | W | Fitchburg HS (MA) | 35 | Boston Hyde Park HS (MA) | 0 | ? | |
| 1921 | L | Fitchburg HS (MA) | 12 | Cleveland West Tech HS (OH) | 13 | ? | |
| 1921 | W | Fitchburg HS (MA) | 35 | Clinton HS (MA) | 0 | ? | |
| 1921 | W | Fitchburg HS (MA) | 16 | Lawrence HS (MA) | 0 | ? | |
| 1921 | T | Fitchburg HS (MA) | 7 | Leominster HS (MA) | 7 | ? | |
| 1921 | W | Fitchburg HS (MA) | 21 | Lowell HS (MA) | 0 | ? | |
| 1921 | W | Fitchburg HS (MA) | 14 | Manchester HS (MA) | 0 | ? | |
| 1921 | W | Fitchburg HS (MA) | 14 | Manchester HS (NH) | 0 | ? | |
| 1921 | L | Fitchburg HS (MA) | 6 | Proviso Township HS (IL) | 13 | ? | |
| 1921 | L | Fitchburg HS (MA) | 13 | Waltham HS (MA) | 14 | ? | |
| 1921 | W | Fitchburg HS (MA) | 43 | Worcester North HS (MA) | 7 | ? | |
| 1921 | W | Fitchburg HS (MA) | 28 | Worcester South HS (MA) | 7 | ? | |
| 1921 | L | Fitzgerald & Clark (TN) | 2 | Tennessee Military Institute | 23 | ? | |
| 1921 | L | Flandreau HS (SD) | 0 | Pipestone HS (MN) | 6 | ? | |
| 1921 | T | Flandreau Indian School (SD) | 7 | Augustana (SD) | 7 | ? | |
| 1921 | L | Flandreau Indian School (SD) | 0 | Si Tanka (SD) | 46 | ? | |
| 1921 | L | Flemington HS (NJ) | 0 | Bernards HS (NJ) | 7 | ? | |
| 1921 | W | Flemington HS (NJ) | 21 | Clinton HS (NJ) | 6 | ? | |
| 1921 | W | Flemington HS (NJ) | 12 | Clinton HS (NJ) | 0 | ? | |
| 1921 | L | Flemington HS (NJ) | 7 | Lambertville HS (NJ) | 12 | ? | |
| 1921 | W | Flemington HS (NJ) | 28 | Lambertville HS (NJ) | 6 | ? | |
| 1921 | L | Flemington HS (NJ) | 7 | Newton HS (NJ) | 46 | ? | |
| 1921 | L | Flemington HS (NJ) | 0 | Princeton HS (NJ) | 35 | ? | |
| 1921 | T | Flemington HS (NJ) | 0 | Somerville HS (NJ) | 0 | ? | |
| 1921 | W | Flint Central HS (MI) | 20 | Alma HS (MI) | 0 | ? | |
| 1921 | L | Flint Central HS (MI) | 20 | Detroit Cass Tech (MI) | 34 | ? | |
| 1921 | W | Flint Central HS (MI) | 28 | Detroit Southeastern HS (MI) | 0 | ? | |
| 1921 | W | Flint Central HS (MI) | 58 | Fenton HS (MI) | 0 | ? | |
| 1921 | T | Flint Central HS (MI) | 0 | Flint Central HS Alumni (MI) | 0 | ? | |
| 1921 | W | Flint Central HS (MI) | 21 | Highland Park HS (MI) | 6 | ? | |
| 1921 | L | Flint Central HS (MI) | 0 | Michigan St. Freshmen | 28 | ? | |
| 1921 | L | Flint Central HS (MI) | 6 | Pontiac HS (MI) | 7 | ? | |
| 1921 | L | Flint Central HS (MI) | 0 | Toledo Scott HS (OH) | 19 | ? | |
| 1921 | T | Flint Central HS Alumni (MI) | 0 | Flint Central HS (MI) | 0 | ? | |
| 1921 | W | Florence HS (CO) | 14 | Canon City HS (CO) | 7 | ? | |
| 1921 | L | Florence HS (CO) | 0 | Canon City HS (CO) | 26 | ? | |
| 1921 | L | Florence HS (CO) | 7 | Pueblo Centennial HS (CO) | 21 | ? | |
| 1921 | L | Florence HS (CO) | 13 | Pueblo Centennial HS (CO) | 21 | ? | |
| 1921 | L | Florence HS (CO) | 0 | Pueblo Central HS (CO) | 6 | ? | |
| 1921 | L | Florence HS (CO) | 13 | Pueblo Central HS (CO) | 20 | ? | |
| 1921 | L | Florence HS (SC) | 0 | Charleston HS (SC) | 61 | ? | |
| 1921 | L | Florence HS (SC) | 0 | Porter Military Academy (SC) | 28 | ? | |
| 1921 | L | Floresville HS (TX) | 0 | Texas Lutheran | 1 | ? | Floresville Forfeits |
| 1921 | W | Florida | 7 | Mercer (GA) | 0 | Gainesville, FL | |
| 1921 | T | Florida | 7 | Mississippi College | 7 | Jacksonville, FL | |
| 1921 | W | Florida | 21 | Oglethorpe (GA) | 3 | Gainesville, FL | |
| 1921 | W | Florida | 34 | Samford (AL) | 0 | Montgomery, AL | |
| 1921 | L | Florida | 0 | Tennessee | 9 | Knoxville, TN | |
| 1921 | W | Florida | 6 | Fort Benning (GA) | 0 | Columbus, GA | |
| 1921 | L | Florida | 10 | North Carolina | 14 | Jacksonville, FL | |
| 1921 | T | Florida | 7 | South Carolina | 7 | Tampa, FL | |
| 1921 | W | Florida | 33 | Rollins (FL) | 0 | Orlando, FL | |
| 1921 | L | Florida | 0 | Carlstrom Field (FL) | 19 | Gainesville, FL | |
| 1921 | W | Florida | 9 | Alabama | 2 | Tuscaloosa, AL | |
| 1921 | L | Florida A&M | 0 | Talladega (AL) | 3 | ? | |
| 1921 | T | Florida A&M | 0 | Tuskegee (AL) | 0 | ? | |
| 1921 | W | Florida Military College | 68 | Jacksonville St. (AL) | 0 | Jacksonville, AL | |
| 1921 | W | Flushing HS (NY) | 7 | Bridgeport HS (CT) | 0 | ? | |
| 1921 | W | Flushing HS (NY) | 14 | Brooklyn Manual Training HS (NY) | 7 | ? | |
| 1921 | L | Flushing HS (NY) | 0 | Brooklyn Prep School (NY) | 6 | ? | |
| 1921 | W | Flushing HS (NY) | 13 | Jamaica HS (NY) | 0 | ? | |
| 1921 | W | Flushing HS (NY) | 21 | Mamaroneck HS (NY) | 0 | ? | |
| 1921 | W | Flushing HS (NY) | 12 | Mount Vernon HS (NY) | 7 | ? | |
| 1921 | L | Flushing HS (NY) | 0 | New York Erasmus Hall HS (NY) | 13 | ? | |
| 1921 | W | Flushing HS (NY) | 26 | New York Morris HS (NY) | 0 | ? | |
| 1921 | W | Flushing HS (NY) | 7 | Saint John's Prep (NY) | 0 | ? | |
| 1921 | L | Flushing HS (OH) | 14 | Cameron HS (WV) | 20 | ? | |
| 1921 | L | Flushing HS (OH) | 0 | Triadelphia HS (WV) | 7 | ? | |
| 1921 | W | Follansbee HS (WV) | 20 | East Liverpool HS (OH) | 16 | ? | |
| 1921 | L | Follansbee HS (WV) | 0 | Linsly Military Institute (WV) | 12 | ? | |
| 1921 | L | Follansbee HS (WV) | 0 | Mingo HS (OH) | 18 | ? | |
| 1921 | W | Follansbee HS (WV) | 27 | Moundsville HS (WV) | 0 | ? | |
| 1921 | L | Follansbee HS (WV) | 0 | Richland District HS (WV) | 6 | ? | |
| 1921 | W | Follansbee HS (WV) | 46 | Smithfield HS (WV) | 0 | ? | |
| 1921 | W | Follansbee HS (WV) | 41 | Triadelphia HS (WV) | 0 | ? | |
| 1921 | L | Follansbee HS (WV) | 0 | Warwood HS (WV) | 6 | ? | |
| 1921 | W | Follansbee HS (WV) | 7 | Wellsburg HS (WV) | 0 | ? | |
| 1921 | T | Fordham (NY) | 0 | Boston College (MA) | 0 | New York, NY | |
| 1921 | L | Fordham (NY) | 7 | Lafayette (PA) | 28 | New York, NY | |
| 1921 | W | Fordham (NY) | 25 | Maine | 14 | New York, NY | |
| 1921 | W | Fordham (NY) | 14 | Springfield (MA) | 0 | Springfield, MA | |
| 1921 | T | Fordham (NY) | 20 | Villanova (PA) | 20 | New York, NY | |
| 1921 | W | Fordham (NY) | 101 | Washington (MD) | 0 | New York, NY | |
| 1921 | L | Fordham (NY) | 7 | Georgetown (DC) | 34 | Washington, DC | |
| 1921 | W | Fordham (NY) | 10 | Catholic (DC) | 0 | New York, NY | |
| 1921 | L | Fordham (NY) | 7 | Muhlenberg (PA) | 12 | Allentown, PA | |
| 1921 | L | Fordham Freshmen (NY) | 0 | New Rochelle HS (NY) | 24 | ? | |
| 1921 | W | Fordham Prep (NY) | 42 | Brooklyn Prep School (NY) | 6 | ? | |
| 1921 | L | Fordham Prep (NY) | 2 | City College of New York Freshmen | 7 | ? | |
| 1921 | W | Fordham Prep (NY) | 25 | New York HS of Commerce (NY) | 0 | ? | |
| 1921 | L | Fordham Prep (NY) | 7 | New York Military Academy | 15 | ? | |
| 1921 | W | Fordham Prep (NY) | 21 | Saint Benedict Prep School (NJ) | 0 | ? | |
| 1921 | W | Fordham Prep (NY) | 35 | Yonkers HS (NY) | 0 | New York, NY | Fordham Field |
| 1921 | L | Ford-Kilvington HS (TN) | 0 | Memphis (TN) | 20 | Memphis, TN | |
| 1921 | L | Fordyce HS (AR) | 13 | Pine Bluff HS (AR) | 16 | ? | |
| 1921 | L | Fordyce HS (AR) | 0 | Pine Bluff HS (AR) | 13 | ? | |
| 1921 | L | Fordyce HS (AR) | 7 | Arkansas-Monticello | 52 | Monticello, AR | |
| 1921 | L | Forest HS | 0 | Toledo Waite HS (OH) | 84 | ? | |
| 1921 | L | Fork Union Military Academy (VA) | 0 | Blackstone Military Academy (VA) | 19 | ? | |
| 1921 | W | Fork Union Military Academy (VA) | 14 | Chatham Training School (VA) | 0 | ? | |
| 1921 | W | Fork Union Military Academy (VA) | 35 | John Marshall HS (VA) | 0 | ? | |
| 1921 | W | Fork Union Military Academy (VA) | 68 | Randolph-Macon Academy (VA) | 0 | ? | |
| 1921 | W | Fork Union Military Academy (VA) | 26 | Richmond Blues (VA) | 0 | ? | |
| 1921 | W | Fork Union Military Academy (VA) | 48 | Richmond JV (VA) | 0 | ? | |
| 1921 | W | Fork Union Military Academy (VA) | 55 | Staunton Deaf & Dumb School (VA) | 0 | ? | |
| 1921 | W | Forsyth HS (MT) | 35 | Glendive HS (MT) | 0 | ? | |
| 1921 | L | Forsyth HS (MT) | 6 | Miles City HS (MT) | 20 | ? | |
| 1921 | W | Forsyth HS (MT) | 65 | Roundup HS (MT) | 0 | ? | |
| 1921 | W | Forsyth HS (MT) | 48 | Sidney HS (MT) | 0 | ? | |
| 1921 | W | Forsyth HS (MT) | 28 | Worden HS (MT) | 2 | ? | |
| 1921 | L | Fort Atkinson HS (WI) | 0 | Kenosha HS (WI) | 21 | ? | |
| 1921 | L | Fort Benning (GA) | 7 | Auburn (AL) | 14 | Auburn, AL | |
| 1921 | W | Fort Benning (GA) | 24 | Mercer (GA) | 7 | Macon, GA | |
| 1921 | W | Fort Benning (GA) | 28 | Piedmont (GA) | 6 | ? | |
| 1921 | L | Fort Benning (GA) | 0 | Tuskegee (AL) | 13 | ? | |
| 1921 | L | Fort Benning (GA) | 4 | Tuskegee (AL) | 6 | ? | |
| 1921 | L | Fort Benning (GA) | 0 | Florida | 6 | Columbus, GA | |
| 1921 | W | Fort Benning (GA) | 27 | Presbyterian (SC) | 0 | Columbus, GA | |
| 1921 | L | Fort Benning (GA) | 12 | Oglethorpe (GA) | 20 | Atlanta, GA | |
| 1921 | L | Fort Bliss (TX) | 0 | New Mexico | 35 | Albuquerque, NM | |
| 1921 | W | Fort Bliss All-Stars (TX) | 14 | Texas-El Paso | 7 | El Paso, TX | |
| 1921 | W | Fort Collins HS (CO) | 14 | Boulder Prep School (CO) | 13 | ? | |
| 1921 | W | Fort Collins HS (CO) | 23 | Greeley HS (CO) | 21 | ? | |
| 1921 | L | Fort Collins HS (CO) | 0 | Gunnison HS (CO) | 18 | ? | |
| 1921 | W | Fort Collins HS (CO) | 20 | Laramie HS (WY) | 13 | ? | |
| 1921 | L | Fort Eustis (VA) | 0 | Newport News HS (VA) | 32 | ? | |
| 1921 | W | Fort Hays St. (KS) | 18 | Kansas Wesleyan | 0 | Salina, KS | |
| 1921 | W | Fort Hays St. (KS) | 32 | McPherson (KS) | 0 | Hays, KS | |
| 1921 | W | Fort Hays St. (KS) | 14 | Saint Mary's (KS) | 7 | Hays, KS | |
| 1921 | W | Fort Hays St. (KS) | 7 | Sterling (KS) | 0 | Sterling, KS | |
| 1921 | L | Fort Hays St. (KS) | 7 | Denver (CO) | 41 | Denver, CO | |
| 1921 | W | Fort Hays St. (KS) | 7 | Bethany (KS) | 0 | Hays, KS | |
| 1921 | W | Fort Hays St. (KS) | 14 | Southwestern (KS) | 7 | Hays, KS | |
| 1921 | L | Fort Knox (KY) | 0 | Kentucky St. | 39 | ? | |
| 1921 | L | Fort Knox (KY) | 7 | Transylvania (KY) | 14 | ? | |
| 1921 | T | Fort Lyon HS (CO) | 6 | Trinidad HS (CO) | 6 | ? | |
| 1921 | L | Fort Madison HS (IA) | 6 | Keokuk HS (IA) | 7 | ? | |
| 1921 | L | Fort Morgan HS (CO) | 25 | Sterling HS (CO) | 28 | ? | |
| 1921 | L | Fort Smith HS (AR) | 7 | Joplin HS (MO) | 17 | ? | |
| 1921 | L | Fort Smith HS (AR) | 0 | Little Rock HS (AR) | 21 | ? | |
| 1921 | L | Fort Smith HS (AR) | 0 | Tulsa Central HS (OK) | 17 | ? | |
| 1921 | W | Fort Valley St. (GA) | 5 | Americus Institute (GA) | 0 | ? | |
| 1921 | L | Fort Wayne HS (IN) | 0 | Toledo Scott HS (OH) | 69 | ? | |
| 1921 | L | Fort Worth HS (TX) | 0 | Terrill Prep School (TX) | 13 | ? | |
| 1921 | L | Fosston HS (MN) | 6 | Crookston HS (MN) | 53 | ? | |
| 1921 | L | Fosston HS (MN) | 7 | Thief River Falls HS (MN) | 32 | ? | |
| 1921 | W | Fostoria HS (OH) | 39 | Akron Central HS (OH) | 0 | ? | |
| 1921 | W | Fostoria HS (OH) | 35 | Akron Central HS (OH) | 0 | ? | |
| 1921 | W | Fostoria HS (OH) | 49 | Bowling Green HS (OH) | 0 | ? | |
| 1921 | W | Fostoria HS (OH) | 20 | Bryan HS (OH) | 0 | ? | |
| 1921 | W | Fostoria HS (OH) | 14 | Cambridge HS (OH) | 7 | ? | |
| 1921 | W | Fostoria HS (OH) | 21 | Chicago Lane Tech HS (IL) | 0 | ? | |
| 1921 | W | Fostoria HS (OH) | 13 | Findlay HS (OH) | 6 | ? | |
| 1921 | L | Fostoria HS (OH) | 20 | Martins Ferry HS (OH) | 26 | ? | |
| 1921 | W | Fostoria HS (OH) | 41 | Norwalk HS (OH) | 7 | ? | |
| 1921 | W | Fostoria HS (OH) | 49 | Toledo Central HS (OH) | 0 | ? | |
| 1921 | L | Fowler HS (CA) | 0 | Dinuba HS (CA) | 13 | ? | |
| 1921 | L | Fowler HS (CA) | 7 | Fresno HS (CA) | 14 | ? | |
| 1921 | L | Fowler HS (CA) | 0 | Selma HS (CA) | 69 | ? | |
| 1921 | L | Fowler HS (CO) | 0 | La Junta HS (CO) | 7 | ? | |
| 1921 | W | Framingham HS (MA) | 12 | Allen Military School (MA) | 0 | ? | |
| 1921 | W | Framingham HS (MA) | 28 | Boston Commerce HS (MA) | 10 | ? | |
| 1921 | W | Framingham HS (MA) | 42 | Concord HS (MA) | 0 | ? | |
| 1921 | W | Framingham HS (MA) | 13 | Greenfield HS (MA) | 0 | ? | |
| 1921 | W | Framingham HS (MA) | 39 | Leominster HS (MA) | 0 | ? | |
| 1921 | T | Framingham HS (MA) | 0 | Marlboro HS (VT) | 0 | ? | |
| 1921 | W | Framingham HS (MA) | 26 | Nashua HS (NH) | 0 | ? | |
| 1921 | W | Framingham HS (MA) | 10 | Natick HS (MA) | 6 | ? | |
| 1921 | W | Framingham HS (MA) | 41 | Saint Marks School (MA) | 7 | ? | |
| 1921 | L | Framingham HS (MA) | 0 | Waltham HS (MA) | 13 | ? | |
| 1921 | W | Framingham HS (MA) | 27 | Worcester Commerce HS (MA) | 0 | ? | |
| 1921 | W | Framingham HS (MA) | 35 | Worcester Trade (MA) | 0 | ? | |
| 1921 | L | Francis Parker Academy | 0 | Chicago Nicholas Senn HS (IL) | 28 | ? | |
| 1921 | T | Frankford HS (PA) | 7 | Bryn Athyn Academy (PA) | 7 | ? | |
| 1921 | W | Frankford HS (PA) | 26 | Germantown Academy (PA) | 6 | ? | |
| 1921 | W | Frankford HS (PA) | 35 | Germantown HS (PA) | 0 | ? | |
| 1921 | W | Frankford HS (PA) | 7 | Haverford College Grammer School (PA) | 0 | ? | |
| 1921 | W | Frankford HS (PA) | 13 | Philadelphia Central HS (PA) | 0 | ? | |
| 1921 | W | Frankford HS (PA) | 32 | Philadelphia Northeast HS (PA) | 0 | ? | |
| 1921 | W | Frankford HS (PA) | 38 | Philadelphia Southern Manual Training HS (PA) | 0 | ? | |
| 1921 | W | Frankford HS (PA) | 6 | Philadelphia West HS (PA) | 0 | ? | |
| 1921 | L | Frankfort HS (KY) | 7 | Louisville HS (KY) | 34 | ? | |
| 1921 | L | Frankfort West HS (IL) | 13 | Murphysboro HS (IL) | 19 | ? | |
| 1921 | W | Franklin & Marshall (PA) | 7 | Albright (PA) | 0 | Lancaster, PA | |
| 1921 | T | Franklin & Marshall (PA) | 0 | Gettysburg (PA) | 0 | Lancaster, PA | |
| 1921 | W | Franklin & Marshall (PA) | 35 | Haverford (PA) | 0 | Haverford, PA | |
| 1921 | T | Franklin & Marshall (PA) | 7 | Swarthmore (PA) | 7 | Lancaster, PA | |
| 1921 | W | Franklin & Marshall (PA) | 41 | Widener (PA) | 14 | Chester, PA | |
| 1921 | L | Franklin & Marshall (PA) | 0 | Pennsylvania | 20 | Philadelphia, PA | |
| 1921 | W | Franklin & Marshall (PA) | 21 | Dickinson (PA) | 7 | Lancaster, PA | |
| 1921 | W | Franklin & Marshall (PA) | 14 | Gallaudet (DC) | 0 | Lancaster, PA | |
| 1921 | W | Franklin & Marshall (PA) | 41 | Ursinus (PA) | 0 | Lancaster, PA | |
| 1921 | T | Franklin & Marshall Academy (PA) | 14 | Allentown Prep School (PA) | 14 | ? | |
| 1921 | W | Franklin & Marshall Academy (PA) | 68 | Gettysburg Academy (PA) | 0 | ? | |
| 1921 | W | Franklin & Marshall Academy (PA) | 35 | Harrisburg Academy (PA) | 0 | ? | |
| 1921 | W | Franklin & Marshall Academy (PA) | 28 | Mercersburg Academy JV (PA) | 0 | ? | |
| 1921 | W | Franklin & Marshall Academy (PA) | 13 | Millersville (PA) | 7 | ? | |
| 1921 | W | Franklin & Marshall Academy (PA) | 21 | Schuylkill College (PA) | 0 | ? | |
| 1921 | W | Franklin & Marshall Academy (PA) | 55 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | L | Franklin & Marshall Academy (PA) | 7 | Shippensburg (PA) | 14 | Lancaster, PA | |
| 1921 | L | Franklin (IN) | 0 | Butler (IN) | 28 | Indianapolis, IN | |
| 1921 | L | Franklin (IN) | 0 | Earlham (IN) | 7 | Richmond, IN | |
| 1921 | W | Franklin (IN) | 7 | Hanover (IN) | 0 | ? | |
| 1921 | L | Franklin (IN) | 0 | Indiana | 47 | Bloomington, IN | |
| 1921 | L | Franklin (IN) | 7 | Kalamazoo (MI) | 48 | Kalamazoo, MI | |
| 1921 | L | Franklin (IN) | 0 | Rose-Hulman Tech (IN) | 10 | ? | |
| 1921 | L | Franklin (IN) | 7 | Wilmington (OH) | 20 | Franklin, IN | |
| 1921 | L | Franklin (IN) | 0 | Detroit (MI) | 35 | Detroit, MI | |
| 1921 | W | Franklin (IN) | 35 | Transylvania (KY) | 0 | Franklin, IN | |
| 1921 | W | Franklin HS | 10 | James John HS (OR) | 0 | ? | |
| 1921 | L | Franklin HS | 0 | Los Angeles Jefferson HS (CA) | 20 | ? | |
| 1921 | L | Franklin HS | 0 | Santa Barbara HS (CA) | 28 | ? | |
| 1921 | L | Franklin HS | 10 | South Pasadena HS (CA) | 13 | ? | |
| 1921 | L | Franklin HS (KY) | 0 | Elizabethtown HS (KY) | 42 | ? | |
| 1921 | L | Franktown HS (VA) | 0 | Newport News HS (VA) | 64 | ? | |
| 1921 | L | Frederick HS (MD) | 0 | Saint James Prep School (MD) | 24 | ? | |
| 1921 | W | Frederick HS (MD) | 32 | Shepherd (WV) | 0 | Shepherdstown, WV | |
| 1921 | W | Frederick HS (MD) | 13 | Shepherd (WV) | 0 | Frederick, MD | |
| 1921 | L | Fredonia HS (KS) | 3 | Independence HS (KS) | 42 | ? | |
| 1921 | T | Freedom HS (PA) | 6 | Ben Avon HS (PA) | 6 | ? | |
| 1921 | L | Freedom HS (PA) | 0 | Monaca HS (PA) | 41 | ? | |
| 1921 | W | Freehold HS (NJ) | 9 | Dover HS (NJ) | 0 | ? | |
| 1921 | L | Freehold HS (NJ) | 6 | Lakewood HS (NJ) | 7 | ? | |
| 1921 | W | Freehold HS (NJ) | 41 | Leonardo HS (NJ) | 0 | ? | |
| 1921 | W | Freehold HS (NJ) | 20 | Long Branch Chattle HS (NJ) | 7 | ? | |
| 1921 | L | Freehold HS (NJ) | 7 | Neptune HS (NJ) | 39 | ? | |
| 1921 | L | Freehold HS (NJ) | 0 | Princeton HS (NJ) | 7 | ? | |
| 1921 | W | Freehold HS (NJ) | 28 | Red Bank HS (NJ) | 0 | ? | |
| 1921 | W | Freehold HS (NJ) | 7 | Saint Benedict Prep School (NJ) | 0 | ? | |
| 1921 | L | Freemont HS | 0 | Berkeley HS (CA) | 81 | ? | |
| 1921 | W | Freeport HS (IL) | 23 | Aurora East HS (IL) | 2 | ? | |
| 1921 | W | Freeport HS (IL) | 70 | Aurora West HS (IL) | 0 | ? | |
| 1921 | W | Freeport HS (IL) | 16 | DeKalb HS (IL) | 0 | ? | |
| 1921 | L | Freeport HS (IL) | 6 | Elgin HS (IL) | 35 | ? | |
| 1921 | W | Freeport HS (IL) | 7 | Harrison Tech | 0 | ? | |
| 1921 | W | Freeport HS (IL) | 62 | Joliet HS (IL) | 0 | ? | |
| 1921 | L | Freeport HS (IL) | 15 | Rockford HS (IL) | 26 | ? | |
| 1921 | W | Freeport HS (IL) | 62 | Warren HS (IL) | 0 | ? | |
| 1921 | L | Freeport HS (NY) | 9 | Adelphi Academy (NY) | 13 | ? | |
| 1921 | L | Freeport HS (NY) | 0 | Brooklyn Evening HS (NY) | 19 | ? | |
| 1921 | L | Freeport HS (NY) | 0 | City College of New York Freshmen | 13 | ? | |
| 1921 | L | Freeport HS (NY) | 0 | Glen Cove HS (NY) | 7 | ? | |
| 1921 | L | Freeport HS (NY) | 0 | Long Island Lawrence HS (NY) | 13 | ? | |
| 1921 | W | Freeport HS (NY) | 12 | Lynbrook HS (NY) | 0 | ? | |
| 1921 | W | Freeport HS (NY) | 7 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | L | Freeport HS (NY) | 0 | Saint Paul's School (NY) | 26 | ? | |
| 1921 | L | Fresno American Legion (CA) | 0 | Santa Clara (CA) | 49 | ? | |
| 1921 | L | Fresno HS (CA) | 7 | Bakersfield HS (CA) | 34 | ? | |
| 1921 | W | Fresno HS (CA) | 54 | Caruthers HS (CA) | 7 | ? | |
| 1921 | W | Fresno HS (CA) | 14 | Fowler HS (CA) | 7 | ? | |
| 1921 | W | Fresno HS (CA) | 7 | Fresno St. (CA) | 0 | Fresno, CA | Practice Game |
| 1921 | W | Fresno HS (CA) | 62 | Fresno St. (CA) | 7 | Fresno, CA | |
| 1921 | W | Fresno HS (CA) | 19 | Hanford HS (CA) | 0 | ? | |
| 1921 | L | Fresno HS (CA) | 7 | Kern County HS (CA) | 34 | ? | |
| 1921 | W | Fresno HS (CA) | 54 | Madera HS (CA) | 0 | ? | |
| 1921 | W | Fresno HS (CA) | 19 | Reedley HS (CA) | 7 | ? | |
| 1921 | W | Fresno HS (CA) | 47 | Sanger HS (CA) | 0 | ? | |
| 1921 | W | Fresno HS (CA) | 7 | Selma HS (CA) | 0 | ? | |
| 1921 | W | Fresno HS (CA) | 28 | Taft HS (CA) | 0 | ? | |
| 1921 | W | Fresno St. (CA) | 12 | California Tech B Team | 0 | Fresno, CA | |
| 1921 | L | Fresno St. (CA) | 0 | Fresno HS (CA) | 7 | Fresno, CA | Practice Game |
| 1921 | L | Fresno St. (CA) | 7 | Fresno HS (CA) | 62 | Fresno, CA | |
| 1921 | W | Fresno St. (CA) | 46 | La Verne (CA) | 0 | ? | |
| 1921 | L | Fresno St. (CA) | 0 | Pacific (CA) | 35 | Stockton, CA | |
| 1921 | L | Fresno St. (CA) | 2 | San Jose St. (CA) | 14 | Fresno, CA | |
| 1921 | L | Fresno St. (CA) | 0 | Cal St.-Chico | 3 | Fresno, CA | |
| 1921 | W | Fresno St. (CA) | 28 | Modesto JC (CA) | 0 | Modesto, CA | |
| 1921 | L | Fresno Tech HS (CA) | 0 | Dinuba HS (CA) | 90 | ? | |
| 1921 | L | Friends (KS) | 0 | Emporia St. (KS) | 42 | Emporia, KS | |
| 1921 | L | Friends (KS) | 7 | Haskell Indian Nations (KS) | 14 | Lawrence, KS | |
| 1921 | W | Friends (KS) | 28 | Sterling (KS) | 6 | Wichita, KS | |
| 1921 | T | Friends (KS) | 0 | Wichita St. (KS) | 0 | Wichita, KS | |
| 1921 | L | Friends (KS) | 0 | Bethany (KS) | 12 | Lindsborg, KS | |
| 1921 | W | Friends (KS) | 36 | Kansas Wesleyan | 0 | Salina, KS | |
| 1921 | L | Friends (KS) | 7 | Southwestern (KS) | 10 | Wichita, KS | |
| 1921 | W | Friends (KS) | 16 | Ottawa (KS) | 7 | Ottawa, KS | |
| 1921 | L | Friends Academy | 7 | Arkansas-Monticello | 14 | Dermott, AR | |
| 1921 | L | Friends Academy | 0 | Port Washington HS (NY) | 21 | ? | |
| 1921 | L | Friends Academy | 0 | Port Washington HS (NY) | 7 | ? | |
| 1921 | L | Friends Central School (PA) | 0 | Chestnut Hill Academy (PA) | 28 | ? | |
| 1921 | L | Friends Central School (PA) | 0 | Episcopal Academy (PA) | 35 | ? | |
| 1921 | L | Friends Central School (PA) | 0 | Germantown Academy (PA) | 55 | ? | |
| 1921 | L | Friends Central School (PA) | 0 | Germantown Friends School (PA) | 60 | ? | |
| 1921 | W | Friends Central School (PA) | 13 | Haddonfield HS (NJ) | 7 | ? | |
| 1921 | L | Friends Central School (PA) | 0 | Haverford College Grammer School (PA) | 6 | ? | |
| 1921 | L | Friends Central School (PA) | 0 | Philadelphia West Catholic HS (PA) | 40 | ? | |
| 1921 | L | Friends Central School (PA) | 0 | Swarthmore Prep School (PA) | 47 | ? | |
| 1921 | L | Fullerton College (CA) | 6 | Sherman Indian School (CA) | 14 | ? | |
| 1921 | W | Fullerton College (CA) | 20 | San Diego St. (CA) | 0 | San Diego, CA | Balboa Stadium |
| 1921 | L | Fullerton HS (CA) | 18 | Kern County HS (CA) | 23 | ? | |
| 1921 | L | Fullerton HS (CA) | 0 | Santa Ana HS (CA) | 7 | ? | |
| 1921 | L | Fullerton HS (CA) | 13 | Santa Monica HS (CA) | 14 | ? | |
| 1921 | W | Furman (SC) | 42 | Citadel (SC) | 0 | Greenville, SC | |
| 1921 | T | Furman (SC) | 0 | Clemson (SC) | 0 | Greenville, SC | |
| 1921 | W | Furman (SC) | 28 | Davidson (NC) | 0 | Greenville, SC | |
| 1921 | W | Furman (SC) | 42 | Erskine (SC) | 7 | Greenville, SC | |
| 1921 | L | Furman (SC) | 0 | Georgia Tech | 69 | Atlanta, GA | |
| 1921 | W | Furman (SC) | 62 | Wofford (SC) | 0 | Greenville, SC | |
| 1921 | W | Furman (SC) | 63 | Newberry (SC) | 0 | Greenville, SC | |
| 1921 | W | Furman (SC) | 37 | Mercer (GA) | 0 | Greenville, SC | |
| 1921 | L | Furman (SC) | 7 | Georgia | 27 | Athens, GA | |
| 1921 | W | Furman (SC) | 7 | South Carolina | 0 | Greenville, SC | |
| 1921 | L | Gadsden Independents (AL) | 0 | Jacksonville St. (AL) | 55 | ? | |
| 1921 | L | Gainesville HS (FL) | 0 | Jacksonville Duval HS (FL) | 56 | ? | |
| 1921 | L | Gainesville HS (GA) | 0 | Athens HS (GA) | 34 | ? | |
| 1921 | W | Galesburg HS (IL) | 28 | Kewanee HS (IL) | 14 | ? | |
| 1921 | W | Galesburg HS (IL) | 21 | Quincy HS (IL) | 0 | ? | |
| 1921 | L | Galileo HS | 7 | Potter School (CA) | 19 | ? | |
| 1921 | L | Galileo HS | 3 | San Francisco HS of Commerce (CA) | 14 | ? | |
| 1921 | L | Galileo HS | 0 | San Francisco University School (CA) | 7 | ? | |
| 1921 | L | Galileo HS | 7 | San Rafael HS (CA) | 60 | ? | |
| 1921 | W | Gallatin County HS (MT) | 26 | Park County HS (MT) | 0 | ? | |
| 1921 | T | Gallaudet (DC) | 14 | Drexel Institute (PA) | 14 | Philadelphia, PA | |
| 1921 | L | Gallaudet (DC) | 0 | Susquehanna (PA) | 26 | Selinsgrove, PA | |
| 1921 | L | Gallaudet (DC) | 0 | Widener (PA) | 12 | Chester, PA | |
| 1921 | L | Gallaudet (DC) | 7 | Saint John's (MD) | 31 | Annapolis, MD | |
| 1921 | L | Gallaudet (DC) | 0 | Franklin & Marshall (PA) | 14 | Lancaster, PA | |
| 1921 | T | Gallaudet (DC) | 7 | George Washington (DC) | 7 | Washington, DC | |
| 1921 | L | Gallipolis HS (OH) | 0 | Huntington HS (WV) | 47 | ? | |
| 1921 | L | Galveston Ball HS (TX) | 0 | Beaumont HS (TX) | 27 | ? | |
| 1921 | L | Galveston Ball HS (TX) | 7 | Orange HS (TX) | 15 | ? | |
| 1921 | L | Gardena HS (CA) | 6 | Loyola Marymount (CA) | 12 | ? | |
| 1921 | L | Gardner HS (MA) | 0 | Clinton HS (MA) | 21 | ? | |
| 1921 | L | Gardner HS (MA) | 0 | Clinton HS (MA) | 26 | ? | |
| 1921 | T | Gary Emerson HS (IN) | 7 | Gary Froebel HS (IN) | 7 | ? | |
| 1921 | W | Gary Froebel HS (IN) | 19 | Bloom Township HS (IL) | 2 | ? | |
| 1921 | W | Gary Froebel HS (IN) | 13 | Chicago East Side HS (IL) | 7 | ? | |
| 1921 | W | Gary Froebel HS (IN) | 53 | Elkhart HS (IN) | 0 | ? | |
| 1921 | T | Gary Froebel HS (IN) | 7 | Gary Emerson HS (IN) | 7 | ? | |
| 1921 | W | Gary Froebel HS (IN) | 41 | Hammond HS (IN) | 0 | ? | |
| 1921 | W | Gary Froebel HS (IN) | 28 | Michigan City HS (IN) | 6 | ? | |
| 1921 | W | Gary Froebel HS (IN) | 7 | Mishawaka HS (IN) | 0 | ? | |
| 1921 | W | Gary Froebel HS (IN) | 48 | Whiting HS (IN) | 0 | ? | |
| 1921 | L | Geddes HS (SD) | 0 | Dallas HS (SD) | 20 | ? | |
| 1921 | W | Geneseo HS (IL) | 20 | Kewanee HS (IL) | 7 | ? | |
| 1921 | W | Geneva (PA) | 21 | Alfred (NY) | 0 | Alfred, NY | |
| 1921 | L | Geneva (PA) | 7 | Allegheny (PA) | 14 | Meadville, PA | |
| 1921 | W | Geneva (PA) | 9 | Duquesne (PA) | 0 | Beaver Falls, PA | |
| 1921 | W | Geneva (PA) | 14 | Grove City (PA) | 0 | Beaver Falls, PA | |
| 1921 | L | Geneva (PA) | 0 | Pittsburgh (PA) | 28 | Beaver Falls, PA | |
| 1921 | L | Geneva (PA) | 0 | Carnegie Mellon (PA) | 7 | Pittsburgh, PA | |
| 1921 | W | Geneva (PA) | 1 | Hiram (OH) | 0 | Beaver Falls, PA | Hiram Forfeits |
| 1921 | T | Geneva (PA) | 0 | Westminster (PA) | 0 | Beaver Falls, PA | |
| 1921 | W | Geneva (PA) | 54 | Juniata (PA) | 0 | Huntingdon, PA | |
| 1921 | W | Geneva HS (NY) | 1 | Binghamton Central HS (NY) | 0 | ? | |
| 1921 | L | Geneva HS (NY) | 0 | Endicott Union HS (NY) | 7 | ? | |
| 1921 | L | Geneva HS (NY) | 0 | Syracuse Central HS (NY) | 12 | ? | |
| 1921 | L | George Washington (DC) | 7 | Catholic (DC) | 19 | Washington, DC | |
| 1921 | W | George Washington (DC) | 41 | Drexel Institute (PA) | 0 | Philadelphia, PA | |
| 1921 | L | George Washington (DC) | 0 | Georgetown (DC) | 28 | Washington, DC | |
| 1921 | T | George Washington (DC) | 7 | William & Mary (VA) | 7 | Norfolk, VA | |
| 1921 | L | George Washington (DC) | 0 | Virginia | 28 | Charlottesville, VA | |
| 1921 | W | George Washington (DC) | 56 | Washington (MD) | 0 | Chestertown, MD | |
| 1921 | W | George Washington (DC) | 20 | McDaniel College (MD) | 7 | Washington, DC | |
| 1921 | T | George Washington (DC) | 7 | Gallaudet (DC) | 7 | Washington, DC | |
| 1921 | W | Georgetown (DC) | 13 | Bethany (WV) | 0 | Washington, DC | |
| 1921 | W | Georgetown (DC) | 14 | Boston College (MA) | 10 | Boston, MA | |
| 1921 | W | Georgetown (DC) | 28 | George Washington (DC) | 0 | Washington, DC | |
| 1921 | W | Georgetown (DC) | 28 | Holy Cross (MA) | 7 | Worcester, MA | |
| 1921 | W | Georgetown (DC) | 66 | Westminster (PA) | 0 | Washington, DC | |
| 1921 | W | Georgetown (DC) | 7 | Lebanon Valley (PA) | 0 | Washington, DC | |
| 1921 | W | Georgetown (DC) | 34 | Fordham (NY) | 7 | Washington, DC | |
| 1921 | W | Georgetown (DC) | 48 | Ursinus (PA) | 6 | Washington, DC | |
| 1921 | L | Georgetown (DC) | 7 | Georgia Tech | 21 | Atlanta, GA | |
| 1921 | W | Georgetown (KY) | 31 | Cumberland (KY) | 7 | ? | |
| 1921 | L | Georgetown (KY) | 0 | DePauw (IN) | 67 | Greencastle, IN | |
| 1921 | L | Georgetown (KY) | 0 | Kentucky | 33 | Lexington, KY | |
| 1921 | L | Georgetown (KY) | 0 | Tennessee-Chattanooga | 31 | Chattanooga, TN | |
| 1921 | L | Georgetown (KY) | 6 | Transylvania (KY) | 14 | Georgetown, KY | |
| 1921 | W | Georgetown (KY) | 33 | Kentucky Wesleyan | 0 | Winchester, KY | |
| 1921 | L | Georgetown (KY) | 0 | Wabash (IN) | 41 | Crawfordsville, IN | |
| 1921 | L | Georgetown (KY) | 0 | Marshall (WV) | 7 | Georgetown, KY | |
| 1921 | T | Georgetown HS (IL) | 14 | Danville HS (IL) | 14 | ? | |
| 1921 | W | Georgia | 22 | Alabama | 0 | Atlanta, GA | |
| 1921 | W | Georgia | 7 | Auburn (AL) | 0 | Columbus, GA | |
| 1921 | W | Georgia | 28 | Clemson (SC) | 0 | Athens, GA | |
| 1921 | L | Georgia | 0 | Dartmouth (NH) | 7 | Atlanta, GA | |
| 1921 | L | Georgia | 7 | Harvard (MA) | 10 | Cambridge, MA | |
| 1921 | W | Georgia | 14 | Oglethorpe (GA) | 0 | Athens, GA | |
| 1921 | T | Georgia | 7 | Vanderbilt (TN) | 7 | Nashville, TN | |
| 1921 | W | Georgia | 28 | Mercer (GA) | 0 | Athens, GA | |
| 1921 | W | Georgia | 21 | Virginia | 0 | Athens, GA | |
| 1921 | W | Georgia | 27 | Furman (SC) | 7 | Athens, GA | |
| 1921 | W | Georgia Freshmen | 26 | Piedmont (GA) | 0 | ? | |
| 1921 | W | Georgia Military Academy (GA) | 20 | Atlanta Boy's HS (GA) | 6 | ? | |
| 1921 | W | Georgia Tech | 14 | Auburn (AL) | 0 | Atlanta, GA | |
| 1921 | W | Georgia Tech | 69 | Furman (SC) | 0 | Atlanta, GA | |
| 1921 | L | Georgia Tech | 7 | Penn St. | 28 | New York, NY | |
| 1921 | W | Georgia Tech | 48 | Rutgers (NJ) | 14 | Atlanta, GA | |
| 1921 | W | Georgia Tech | 42 | Wake Forest (NC) | 0 | Atlanta, GA | |
| 1921 | W | Georgia Tech | 41 | Oglethorpe (GA) | 0 | Atlanta, GA | |
| 1921 | W | Georgia Tech | 48 | Clemson (SC) | 7 | Atlanta, GA | |
| 1921 | W | Georgia Tech | 70 | Davidson (NC) | 0 | Atlanta, GA | |
| 1921 | W | Georgia Tech | 21 | Georgetown (DC) | 7 | Atlanta, GA | |
| 1921 | W | Georgia Tech Freshmen | 21 | Piedmont (GA) | 7 | ? | |
| 1921 | W | Germantown Academy (PA) | 28 | Chestnut Hill Academy (PA) | 0 | ? | |
| 1921 | T | Germantown Academy (PA) | 0 | Episcopal Academy (PA) | 0 | ? | |
| 1921 | L | Germantown Academy (PA) | 6 | Frankford HS (PA) | 26 | ? | |
| 1921 | W | Germantown Academy (PA) | 55 | Friends Central School (PA) | 0 | ? | |
| 1921 | T | Germantown Academy (PA) | 0 | Germantown Friends School (PA) | 0 | ? | |
| 1921 | L | Germantown Academy (PA) | 7 | Haverford College Grammer School (PA) | 14 | ? | |
| 1921 | L | Germantown Academy (PA) | 0 | Penn Charter School (PA) | 20 | ? | |
| 1921 | L | Germantown Academy (PA) | 6 | Saint Luke's School (PA) | 19 | ? | |
| 1921 | W | Germantown Friends School (PA) | 39 | Chestnut Hill Academy (PA) | 0 | ? | |
| 1921 | W | Germantown Friends School (PA) | 60 | Friends Central School (PA) | 0 | ? | |
| 1921 | T | Germantown Friends School (PA) | 0 | Germantown Academy (PA) | 0 | ? | |
| 1921 | W | Germantown Friends School (PA) | 3 | Ridley Park HS (PA) | 0 | ? | |
| 1921 | W | Germantown HS (PA) | 6 | Camden HS (NJ) | 0 | ? | |
| 1921 | W | Germantown HS (PA) | 9 | Collingswood HS (NJ) | 7 | ? | |
| 1921 | L | Germantown HS (PA) | 0 | Frankford HS (PA) | 35 | ? | |
| 1921 | L | Germantown HS (PA) | 7 | Norristown HS (PA) | 24 | ? | |
| 1921 | L | Germantown HS (PA) | 0 | Philadelphia Central HS (PA) | 14 | ? | |
| 1921 | W | Germantown HS (PA) | 24 | Philadelphia Northeast HS (PA) | 3 | ? | |
| 1921 | W | Germantown HS (PA) | 28 | Philadelphia Southern Manual Training HS (PA) | 0 | ? | |
| 1921 | L | Germantown HS (PA) | 6 | Philadelphia West HS (PA) | 13 | ? | |
| 1921 | L | Germantown HS (PA) | 0 | Saint Joseph's Prep School (PA) | 16 | ? | |
| 1921 | W | Gettysburg (PA) | 15 | Dickinson (PA) | 0 | Carlisle, PA | |
| 1921 | T | Gettysburg (PA) | 0 | Franklin & Marshall (PA) | 0 | Lancaster, PA | |
| 1921 | W | Gettysburg (PA) | 28 | Mount Saint Mary's (MD) | 0 | Gettysburg, PA | |
| 1921 | L | Gettysburg (PA) | 13 | Muhlenberg (PA) | 17 | Gettysburg, PA | |
| 1921 | W | Gettysburg (PA) | 34 | Ursinus (PA) | 0 | York, PA | |
| 1921 | L | Gettysburg (PA) | 0 | Penn St. | 24 | State College, PA | |
| 1921 | L | Gettysburg (PA) | 10 | Villanova (PA) | 13 | York, PA | |
| 1921 | L | Gettysburg (PA) | 0 | Pennsylvania | 7 | Philadelphia, PA | |
| 1921 | L | Gettysburg (PA) | 7 | Bucknell (PA) | 34 | Harrisburg, PA | |
| 1921 | L | Gettysburg Academy (PA) | 0 | Franklin & Marshall Academy (PA) | 68 | ? | |
| 1921 | W | Gettysburg Academy (PA) | 21 | Harrisburg Academy (PA) | 0 | ? | |
| 1921 | L | Gettysburg Academy (PA) | 0 | Lancaster HS (PA) | 98 | ? | |
| 1921 | L | Gettysburg B Team (PA) | 0 | Mercersburg Academy (PA) | 48 | ? | |
| 1921 | L | Gettysburg HS (OH) | 0 | Saint Marys HS (OH) | 18 | ? | |
| 1921 | L | Gettysburg HS (PA) | 20 | Harrisburg Academy (PA) | 23 | ? | |
| 1921 | L | Gettysburg HS (PA) | 0 | Huntingdon HS (PA) | 67 | ? | |
| 1921 | L | Gilbert HS (MN) | 0 | Aurora HS (MN) | 28 | ? | |
| 1921 | W | Gilman Country School (MD) | 14 | Alexandria Episcopal HS (VA) | 6 | ? | |
| 1921 | W | Gilman Country School (MD) | 55 | Army & Navy Prep School (DC) | 0 | ? | |
| 1921 | W | Gilman Country School (MD) | 62 | Baltimore City College (MD) | 7 | ? | |
| 1921 | W | Gilman Country School (MD) | 49 | Baltimore Friends School (MD) | 14 | ? | |
| 1921 | W | Gilman Country School (MD) | 45 | McDonogh School (MD) | 0 | ? | |
| 1921 | W | Gilman Country School (MD) | 40 | Mount Saint Joseph's College (MD) | 0 | ? | |
| 1921 | W | Gilman Country School (MD) | 31 | Peddie Institute (NJ) | 7 | ? | |
| 1921 | W | Gilman Country School (MD) | 66 | Tome Institute (MD) | 0 | ? | |
| 1921 | L | Girard HS (OH) | 0 | Youngstown South HS (OH) | 39 | ? | |
| 1921 | L | Glasgow HS (KY) | 0 | Elizabethtown HS (KY) | 29 | ? | |
| 1921 | L | Glasgow HS (KY) | 0 | Elizabethtown HS (KY) | 65 | ? | |
| 1921 | W | Glassboro HS (NJ) | 21 | Ambler HS (PA) | 0 | ? | |
| 1921 | W | Glassboro HS (NJ) | 99 | Paulsboro HS (NJ) | 6 | ? | |
| 1921 | L | Glassboro HS (NJ) | 0 | Penns Grove HS (NJ) | 21 | ? | |
| 1921 | T | Glassboro HS (NJ) | 0 | Pineland HS | 0 | ? | |
| 1921 | T | Glassboro HS (NJ) | 19 | Salem HS (NJ) | 19 | ? | |
| 1921 | W | Glassboro HS (NJ) | 32 | Upper Darby HS (PA) | 0 | ? | |
| 1921 | L | Glassboro HS (NJ) | 0 | Woodbury HS (NJ) | 10 | ? | |
| 1921 | W | Glassboro HS (NJ) | 13 | Woodstown HS (NJ) | 0 | ? | |
| 1921 | W | Glen Cove HS (NY) | 7 | Freeport HS (NY) | 0 | ? | |
| 1921 | L | Glen Cove HS (NY) | 7 | Marquand School (NY) | 27 | ? | |
| 1921 | T | Glen Cove HS (NY) | 0 | Port Washington HS (NY) | 0 | ? | |
| 1921 | W | Glen Cove HS (NY) | 42 | Saint Francis Prep (NY) | 0 | Glen Cove, NY | |
| 1921 | L | Glencoe HS (MN) | 0 | Willmar HS (MN) | 79 | ? | |
| 1921 | L | Glendive HS (MT) | 0 | Forsyth HS (MT) | 35 | ? | |
| 1921 | W | Glenn County HS (CA) | 40 | Brothers College | 0 | ? | |
| 1921 | W | Glenn County HS (CA) | 26 | Chico HS (CA) | 0 | ? | |
| 1921 | W | Glenn County HS (CA) | 41 | Marysville HS (CA) | 14 | ? | |
| 1921 | W | Glenn County HS (CA) | 13 | Oakland Tech (CA) | 0 | ? | |
| 1921 | L | Glenn County HS (CA) | 6 | Preston Industrial School (CA) | 7 | ? | |
| 1921 | L | Glenn County HS (CA) | 0 | Sacramento HS (CA) | 20 | ? | |
| 1921 | W | Glenn County HS (CA) | 32 | Woodland HS (CA) | 7 | ? | |
| 1921 | W | Glenpool HS (OK) | 52 | Collinsville HS (OK) | 0 | ? | |
| 1921 | W | Glens Falls HS (NY) | 7 | Albany HS (NY) | 0 | ? | |
| 1921 | W | Glens Falls HS (NY) | 21 | Saratoga Springs HS (NY) | 10 | ? | |
| 1921 | W | Glenville HS | 21 | Cleveland Central HS (OH) | 0 | ? | |
| 1921 | L | Glenville HS | 0 | Cleveland East Tech HS (OH) | 35 | ? | |
| 1921 | L | Glenville St. (WV) | 7 | Broaddus College (WV) | 42 | ? | |
| 1921 | L | Glenville St. (WV) | 0 | West Virginia B Team | 35 | ? | |
| 1921 | W | Glenwood HS (MN) | 7 | American Legion | 0 | ? | |
| 1921 | W | Glenwood HS (MN) | 13 | Hancock HS (MN) | 6 | ? | |
| 1921 | W | Glenwood HS (MN) | 20 | Long Prairie HS (MN) | 0 | ? | |
| 1921 | L | Glenwood HS (MN) | 0 | Montevideo HS (MN) | 12 | ? | |
| 1921 | W | Glenwood HS (MN) | 20 | Osakis HS (MN) | 0 | ? | |
| 1921 | W | Glenwood HS (MN) | 86 | West Central School of Agriculture (MN) | 0 | ? | |
| 1921 | W | Glenwood HS (MN) | 28 | Wheaton HS (MN) | 13 | ? | |
| 1921 | L | Gloucester HS (MA) | 0 | Beverly HS (MA) | 21 | ? | |
| 1921 | W | Gloucester HS (MA) | 30 | Chelsea HS (MA) | 0 | ? | |
| 1921 | L | Gloucester HS (MA) | 7 | Lynn Classical HS (MA) | 21 | ? | |
| 1921 | L | Gloucester HS (MA) | 0 | Marblehead HS (MA) | 13 | ? | |
| 1921 | L | Gloucester HS (MA) | 7 | Moorestown HS (NJ) | 14 | ? | |
| 1921 | L | Gloucester HS (MA) | 2 | Palmyra HS (NJ) | 12 | ? | |
| 1921 | L | Gloucester HS (MA) | 0 | Peabody HS (MA) | 52 | ? | |
| 1921 | W | Gloucester HS (MA) | 7 | Revere HS (MA) | 0 | ? | |
| 1921 | L | Gloucester HS (MA) | 0 | Swampscott HS (MA) | 23 | ? | |
| 1921 | W | Gloucester HS (MA) | 7 | Winthrop HS (MA) | 0 | ? | |
| 1921 | L | Gloucester HS (NJ) | 0 | Haddon Heights HS (NJ) | 6 | ? | |
| 1921 | L | Gloucester HS (NJ) | 0 | Hammonton HS (NJ) | 28 | ? | |
| 1921 | L | Gloucester HS (NJ) | 0 | Woodstown HS (NJ) | 13 | ? | |
| 1921 | W | Gloversville HS (NY) | 7 | Albany Academy (NY) | 0 | ? | |
| 1921 | L | Gloversville HS (NY) | 21 | Albany HS (NY) | 28 | ? | |
| 1921 | W | Gloversville HS (NY) | 19 | Canajoharie HS (NY) | 6 | ? | |
| 1921 | W | Gloversville HS (NY) | 34 | Edison Drafting School | 14 | ? | |
| 1921 | W | Gloversville HS (NY) | 35 | Greenwich HS (NY) | 7 | ? | |
| 1921 | W | Gloversville HS (NY) | 36 | Troy HS (NY) | 13 | ? | |
| 1921 | W | Gloversville HS (NY) | 20 | Watervliet HS (NY) | 0 | ? | |
| 1921 | W | Goldsboro HS (NC) | 27 | Chapel Hill HS (NC) | 0 | ? | |
| 1921 | L | Goldsboro HS (NC) | 0 | New Hanover HS (NC) | 13 | ? | |
| 1921 | L | Gonzaga (WA) | 7 | 9th Army Corps (WA) | 10 | Fort Lewis, WA | |
| 1921 | L | Gonzaga (WA) | 0 | Idaho | 6 | Spokane, WA | |
| 1921 | T | Gonzaga (WA) | 0 | Montana | 0 | Spokane, WA | |
| 1921 | W | Gonzaga (WA) | 7 | Montana St. | 2 | Spokane, WA | |
| 1921 | L | Gonzaga (WA) | 7 | Washington St. | 54 | Spokane, WA | |
| 1921 | L | Gonzaga (WA) | 7 | Multnomah AC (OR) | 21 | Portland, OR | |
| 1921 | W | Gonzaga (WA) | 36 | College of Idaho | 0 | Caldwell, ID | |
| 1921 | L | Gonzales HS (TX) | 0 | Texas Lutheran | 6 | ? | |
| 1921 | L | Gooding (ID) | 0 | College of Idaho | 56 | ? | |
| 1921 | L | Gooding (ID) | 10 | Idaho St. | 17 | Gooding, ID | |
| 1921 | L | Gooding (ID) | 7 | Montana Wesleyan | 27 | Gooding, ID | |
| 1921 | W | Gordon (GA) | 41 | Atlanta Boy's HS (GA) | 0 | ? | |
| 1921 | W | Gordon JV (GA) | 82 | Atlanta Boy's HS (GA) | 12 | ? | |
| 1921 | L | Gothenburg HS (NE) | 7 | Cambridge HS (NE) | 27 | ? | |
| 1921 | L | Gothenburg HS (NE) | 6 | Nebraska School of Agriculture | 20 | ? | |
| 1921 | L | Gothenburg HS (NE) | 0 | North Platte HS (NE) | 21 | ? | |
| 1921 | L | Gouveneur | 0 | Massena HS (NY) | 66 | ? | |
| 1921 | L | Governor Dummer Academy (MA) | 0 | Middlesex School (MA) | 34 | ? | |
| 1921 | L | Governor Dummer Academy (MA) | 6 | Roxbury Latin School (MA) | 7 | ? | |
| 1921 | T | Graceland (IA) | 0 | Central (IA) | 0 | Lamoni, IA | |
| 1921 | L | Graceland (IA) | 3 | Chillicothe Business College (MO) | 19 | Chillicothe, MO | |
| 1921 | W | Graceland (IA) | 31 | Simpson (IA) | 0 | Lamoni, IA | |
| 1921 | L | Graceland (IA) | 6 | Still College (IA) | 7 | Lamoni, IA | |
| 1921 | L | Graceland (IA) | 6 | Palmer College (MO) | 20 | Albany, MO | |
| 1921 | W | Graceland (IA) | 23 | Northwest Missouri St. | 19 | Maryville, MO | |
| 1921 | L | Graceland (IA) | 0 | Benedictine (KS) | 28 | Atchison, KS | |
| 1921 | T | Grafton Alumni (WV) | 0 | Grafton HS (WV) | 0 | ? | |
| 1921 | L | Grafton HS | 6 | Sewickley HS (PA) | 7 | ? | |
| 1921 | W | Grafton HS (ND) | 27 | Stephen HS (MN) | 0 | ? | |
| 1921 | W | Grafton HS (ND) | 28 | Williston HS (ND) | 14 | ? | |
| 1921 | W | Grafton HS (WV) | 42 | Belington HS (WV) | 0 | ? | |
| 1921 | W | Grafton HS (WV) | 28 | Cameron HS (WV) | 0 | ? | |
| 1921 | W | Grafton HS (WV) | 7 | Clarksburg Victory HS (WV) | 0 | ? | |
| 1921 | L | Grafton HS (WV) | 0 | Elkins HS (WV) | 14 | ? | |
| 1921 | W | Grafton HS (WV) | 28 | Fairmont East Side HS (WV) | 6 | ? | |
| 1921 | W | Grafton HS (WV) | 14 | Fairmont HS (WV) | 0 | ? | |
| 1921 | T | Grafton HS (WV) | 0 | Grafton Alumni (WV) | 0 | ? | |
| 1921 | T | Grafton HS (WV) | 7 | Mannington HS (WV) | 7 | ? | |
| 1921 | T | Grafton HS (WV) | 14 | Morgantown HS (WV) | 14 | ? | |
| 1921 | L | Grafton HS (WV) | 7 | Washington Irving HS (WV) | 27 | ? | |
| 1921 | T | Grafton HS (WV) | 6 | Weston HS (WV) | 6 | ? | |
| 1921 | L | Grand Haven HS (MI) | 0 | Muskegon HS (MI) | 28 | ? | |
| 1921 | T | Grand Island College (NE) | 0 | Cotner (NE) | 0 | ? | |
| 1921 | L | Grand Island College (NE) | 7 | Hastings (NE) | 14 | ? | |
| 1921 | L | Grand Island College (NE) | 0 | Peru St. (NE) | 27 | ? | |
| 1921 | L | Grand Island College (NE) | 0 | Wayne St. (NE) | 14 | Wayne, NE | |
| 1921 | L | Grand Island College (NE) | 7 | Colorado College | 37 | Colorado Springs, CO | |
| 1921 | W | Grand Island College (NE) | 14 | York (NE) | 3 | ? | |
| 1921 | L | Grand Island College (NE) | 0 | Nebraska Wesleyan | 17 | Grand Island, NE | |
| 1921 | L | Grand Junction HS (CO) | 0 | Gunnison HS (CO) | 56 | ? | |
| 1921 | W | Grand Junction HS (CO) | 14 | Olathe HS (CO) | 0 | ? | |
| 1921 | L | Grand Meadow HS (MN) | 0 | Austin HS (MN) | 40 | ? | |
| 1921 | L | Grand Meadow HS (MN) | 6 | Stewartville HS (MN) | 14 | ? | |
| 1921 | L | Grand Rapids Catholic Central HS (MI) | 0 | Grand Rapids Union HS (MI) | 14 | ? | |
| 1921 | W | Grand Rapids Central HS (MI) | 49 | Detroit Northern HS (MI) | 0 | ? | |
| 1921 | W | Grand Rapids Central HS (MI) | 25 | Grand Rapids Union HS (MI) | 0 | ? | |
| 1921 | L | Grand Rapids Central HS (MI) | 0 | Muskegon HS (MI) | 14 | ? | |
| 1921 | L | Grand Rapids Central HS (MI) | 0 | Saginaw East HS (MI) | 26 | ? | |
| 1921 | L | Grand Rapids HS (MN) | 0 | Coleraine HS (MN) | 41 | ? | |
| 1921 | L | Grand Rapids HS (MN) | 0 | Coleraine HS (MN) | 54 | ? | |
| 1921 | W | Grand Rapids JC (MI) | 13 | Hillsdale (MI) | 0 | ? | |
| 1921 | W | Grand Rapids JC (MI) | 7 | Hope (MI) | 3 | ? | |
| 1921 | L | Grand Rapids JC (MI) | 0 | Central Michigan | 7 | Grand Rapids, MI | |
| 1921 | L | Grand Rapids JC (MI) | 0 | Olivet (MI) | 6 | ? | |
| 1921 | L | Grand Rapids JC (MI) | 0 | Wayne St. (MI) | 39 | Detroit, MI | |
| 1921 | W | Grand Rapids Union HS (MI) | 28 | Allegan HS (MI) | 14 | ? | |
| 1921 | W | Grand Rapids Union HS (MI) | 14 | Grand Rapids Catholic Central HS (MI) | 0 | ? | |
| 1921 | L | Grand Rapids Union HS (MI) | 0 | Grand Rapids Central HS (MI) | 25 | ? | |
| 1921 | W | Grand Rapids Union HS (MI) | 12 | Grand Rapids South HS (MI) | 0 | ? | |
| 1921 | W | Grand Rapids Union HS (MI) | 13 | Grand Rapids Union HS Alumni (MI) | 12 | ? | |
| 1921 | L | Grand Rapids Union HS (MI) | 0 | Holland HS (MI) | 7 | ? | |
| 1921 | L | Grand Rapids Union HS (MI) | 0 | Kalamazoo HS (MI) | 27 | ? | |
| 1921 | L | Grand Rapids Union HS (MI) | 6 | Lansing HS (MI) | 21 | ? | |
| 1921 | L | Grand Rapids Union HS (MI) | 0 | Muskegon HS (MI) | 34 | ? | |
| 1921 | W | Grand Rapids Union HS (MI) | 32 | Plainwell HS (MI) | 0 | ? | |
| 1921 | W | Grand Rapids Union HS (MI) | 40 | Saint Joseph HS (MI) | 0 | ? | |
| 1921 | L | Grand Rapids Union HS Alumni (MI) | 12 | Grand Rapids Union HS (MI) | 13 | ? | |
| 1921 | L | Granite City HS (IL) | 0 | Principia Academy (MO) | 56 | ? | |
| 1921 | L | Granite Falls HS (WA) | 7 | Arlington HS (WA) | 34 | ? | |
| 1921 | W | Granite Falls HS (WA) | 33 | Coupeville HS (WA) | 13 | ? | |
| 1921 | L | Granite Falls HS (WA) | 0 | Edmonds HS (WA) | 24 | ? | |
| 1921 | W | Granite Falls HS (WA) | 78 | Lake Stevens HS (WA) | 0 | ? | |
| 1921 | L | Granite Falls HS (WA) | 0 | Marysville HS (WA) | 119 | ? | |
| 1921 | L | Granite Falls HS (WA) | 0 | Monroe HS (WA) | 40 | ? | |
| 1921 | L | Granite Falls HS (WA) | 0 | Snohomish HS (WA) | 28 | ? | |
| 1921 | L | Granite Falls HS (WA) | 7 | Stanwood HS (WA) | 40 | ? | |
| 1921 | L | Granite Falls HS (WA) | 0 | Sultan HS (WA) | 76 | ? | |
| 1921 | W | Granite Falls HS (WA) | 41 | Tulalip Independents (WA) | 7 | ? | |
| 1921 | W | Granite HS (UT) | 15 | Ogden HS (UT) | 0 | ? | |
| 1921 | L | Granite HS (UT) | 0 | Salt Lake City East Side HS (UT) | 26 | ? | |
| 1921 | L | Grants Pass HS (OR) | 0 | Ashland HS (OR) | 61 | ? | |
| 1921 | L | Grants Pass HS (OR) | 6 | Ashland HS (OR) | 49 | ? | |
| 1921 | W | Grantsville HS (UT) | 17 | Westminster College (UT) | 7 | ? | |
| 1921 | W | Granville HS (NY) | 14 | Saratoga Springs HS (NY) | 6 | ? | |
| 1921 | W | Great Lakes NTS (IL) | 20 | DePaul (IL) | 0 | ? | |
| 1921 | W | Greeley HS (CO) | 48 | Boulder Prep School (CO) | 6 | ? | |
| 1921 | W | Greeley HS (CO) | 27 | Denver East HS (CO) | 10 | ? | |
| 1921 | W | Greeley HS (CO) | 7 | Denver South HS (CO) | 0 | ? | |
| 1921 | W | Greeley HS (CO) | 48 | Denver West HS (CO) | 10 | ? | |
| 1921 | W | Greeley HS (CO) | 7 | Eaton HS (CO) | 0 | ? | |
| 1921 | L | Greeley HS (CO) | 21 | Fort Collins HS (CO) | 23 | ? | |
| 1921 | L | Greeley HS (CO) | 0 | Longmont HS (CO) | 7 | ? | |
| 1921 | W | Greeley HS (CO) | 14 | Loveland HS (CO) | 13 | ? | |
| 1921 | W | Greeley HS (CO) | 26 | Windsor HS (CO) | 7 | ? | |
| 1921 | W | Green Bay East HS (WI) | 27 | Saint Norbert (WI) | 6 | De Pere, WI | |
| 1921 | L | Green Bay West HS (WI) | 6 | Marquette Academy (WI) | 27 | ? | |
| 1921 | W | Green Mountain Pros | 13 | Hoosac School (NY) | 7 | ? | |
| 1921 | L | Greenbrier Military Academy (WV) | 0 | Charleston (WV) | 69 | Barboursville, WV | |
| 1921 | W | Greenbrier Military Academy (WV) | 7 | Charleston HS (WV) | 6 | Lewisburg, WV | |
| 1921 | W | Greenbrier Military Academy (WV) | 3 | Fishburne Military School (VA) | 0 | ? | |
| 1921 | W | Greenbrier Military Academy (WV) | 6 | Huntington HS (WV) | 0 | ? | |
| 1921 | L | Greenfield HS (MA) | 0 | Framingham HS (MA) | 13 | ? | |
| 1921 | L | Greenfield HS (OH) | 0 | Chillicothe HS (OH) | 47 | ? | |
| 1921 | L | Greenfield HS (OH) | 0 | Cincinnati Hughes HS (OH) | 34 | ? | |
| 1921 | L | Greenfield HS (OH) | 0 | Wilmington HS (OH) | 28 | ? | |
| 1921 | L | Greenfield HS (OH) | 0 | Xenia Central HS (OH) | 38 | ? | |
| 1921 | W | Greensboro HS (NC) | 28 | Chapel Hill HS (NC) | 0 | ? | |
| 1921 | L | Greensboro HS (NC) | 7 | Durham HS (NC) | 14 | ? | |
| 1921 | W | Greensburg HS (PA) | 21 | Harrisburg Tech HS (PA) | 6 | ? | |
| 1921 | W | Greensburg HS (PA) | 14 | Johnstown HS (PA) | 13 | ? | |
| 1921 | W | Greensburg HS (PA) | 25 | Slippery Rock (PA) | 0 | Greensburg, PA | |
| 1921 | L | Greenville HS (KY) | 0 | Morganfield HS (KY) | 7 | ? | |
| 1921 | W | Greenville HS (MS) | 34 | Belzoni HS (MS) | 0 | ? | |
| 1921 | L | Greenville HS (MS) | 0 | Chamberlain Hunt Academy (MS) | 20 | ? | |
| 1921 | L | Greenville HS (MS) | 0 | Clarksdale HS (MS) | 26 | ? | |
| 1921 | T | Greenville HS (MS) | 7 | Greenville Military Academy (MS) | 7 | ? | |
| 1921 | T | Greenville HS (MS) | 7 | Greenwood HS (MS) | 7 | ? | |
| 1921 | W | Greenville HS (MS) | 92 | Indianola HS (MS) | 0 | ? | |
| 1921 | W | Greenville HS (MS) | 54 | Lake Providence HS (LA) | 0 | ? | |
| 1921 | T | Greenville Military Academy (MS) | 7 | Greenville HS (MS) | 7 | ? | |
| 1921 | L | Greenwich HS (CT) | 0 | King School (CT) | 7 | ? | |
| 1921 | L | Greenwich HS (NY) | 7 | Gloversville HS (NY) | 35 | ? | |
| 1921 | L | Greenwood HS (MS) | 0 | Clarksdale HS (MS) | 27 | ? | |
| 1921 | T | Greenwood HS (MS) | 7 | Greenville HS (MS) | 7 | ? | |
| 1921 | W | Greenwood HS (MS) | 40 | Grenada HS (MS) | 0 | ? | |
| 1921 | W | Gregory HS (SD) | 7 | Dallas HS (SD) | 6 | ? | |
| 1921 | L | Gregory HS (SD) | 0 | Dallas HS (SD) | 7 | ? | |
| 1921 | W | Grenada HS (MS) | 21 | Calhoun City HS (MS) | 0 | ? | |
| 1921 | L | Grenada HS (MS) | 0 | Charleston HS (MS) | 13 | ? | |
| 1921 | W | Grenada HS (MS) | 34 | Durant HS (MS) | 12 | ? | |
| 1921 | L | Grenada HS (MS) | 0 | Greenwood HS (MS) | 40 | ? | |
| 1921 | W | Grenada HS (MS) | 53 | Kosciusko HS (MS) | 7 | ? | |
| 1921 | W | Grenada HS (MS) | 19 | Oxford HS (MS) | 13 | ? | |
| 1921 | W | Grenada HS (MS) | 26 | Water Valley HS (MS) | 0 | ? | |
| 1921 | W | Grenada HS (MS) | 21 | Water Valley HS (MS) | 0 | ? | |
| 1921 | W | Grenada HS (MS) | 19 | Winona HS (MS) | 13 | ? | |
| 1921 | L | Gresham HS (OR) | 0 | Astoria HS (OR) | 42 | ? | |
| 1921 | L | Gridley HS (IL) | 0 | Chicago Englewood HS (IL) | 56 | ? | |
| 1921 | L | Grinnell (IA) | 0 | Coe (IA) | 10 | Grinnell, IA | |
| 1921 | L | Grinnell (IA) | 10 | Drake (IA) | 21 | Des Moines, IA | |
| 1921 | L | Grinnell (IA) | 13 | Washington (MO) | 14 | Grinnell, IA | |
| 1921 | W | Grinnell (IA) | 35 | Simpson (IA) | 0 | Indianola, IA | |
| 1921 | L | Grinnell (IA) | 7 | Kansas St. | 21 | Manhattan, KS | |
| 1921 | L | Grinnell (IA) | 3 | Iowa St. | 21 | Ames, IA | |
| 1921 | W | Grinnell (IA) | 13 | Cornell College (IA) | 6 | Grinnell, IA | |
| 1921 | L | Groton HS (NY) | 3 | Middlesex School (MA) | 14 | ? | |
| 1921 | W | Groton School (MA) | 28 | Boston Latin School (MA) | 0 | ? | |
| 1921 | W | Grove City (PA) | 7 | Allegheny (PA) | 0 | Meadville, PA | |
| 1921 | W | Grove City (PA) | 44 | Duquesne (PA) | 0 | Pittsburgh, PA | |
| 1921 | L | Grove City (PA) | 0 | Geneva (PA) | 14 | Beaver Falls, PA | |
| 1921 | W | Grove City (PA) | 27 | Marietta (OH) | 2 | Grove City, PA | |
| 1921 | W | Grove City (PA) | 13 | Westminster (PA) | 0 | New Wilmington, PA | |
| 1921 | W | Grove City (PA) | 6 | Thiel (PA) | 0 | Greenville, PA | |
| 1921 | L | Grove City (PA) | 0 | Bethany (WV) | 14 | Grove City, PA | |
| 1921 | W | Grove City (PA) | 21 | Saint Bonaventure (NY) | 0 | Grove City, PA | |
| 1921 | W | Grove City (PA) | 28 | West Virginia Wesleyan | 0 | Grove City, PA | |
| 1921 | L | Grove City JV (PA) | 3 | Slippery Rock (PA) | 35 | Slippery Rock, PA | |
| 1921 | L | Guilford (NC) | 0 | Elon (NC) | 7 | Elon College, NC | |
| 1921 | W | Guilford (NC) | 65 | Lenoir-Rhyne (NC) | 0 | Greensboro, NC | |
| 1921 | L | Guilford (NC) | 14 | Lynchburg (VA) | 32 | Lynchburg, VA | |
| 1921 | L | Guilford (NC) | 0 | Wake Forest (NC) | 28 | Wake Forest, NC | |
| 1921 | L | Guilford (NC) | 0 | Roanoke (VA) | 14 | Salem, VA | |
| 1921 | L | Guilford (NC) | 0 | Duke (NC) | 28 | Durham, NC | |
| 1921 | T | Guilford (NC) | 0 | Elon (NC) | 0 | Greensboro, NC | |
| 1921 | L | Guilford JV (NC) | 6 | Durham HS (NC) | 13 | ? | |
| 1921 | W | Gunnison HS (CO) | 69 | Cedaredge HS (CO) | 0 | ? | |
| 1921 | W | Gunnison HS (CO) | 6 | Delta HS (CO) | 3 | ? | |
| 1921 | W | Gunnison HS (CO) | 18 | Fort Collins HS (CO) | 0 | ? | |
| 1921 | W | Gunnison HS (CO) | 56 | Grand Junction HS (CO) | 0 | ? | |
| 1921 | W | Gunnison HS (CO) | 1 | Hotchkiss HS (CO) | 0 | ? | Hotchkiss HS Forfeits |
| 1921 | W | Gunnison HS (CO) | 62 | Monte Vista HS (CO) | 0 | ? | |
| 1921 | W | Gunnison HS (CO) | 76 | Montrose HS (CO) | 0 | ? | |
| 1921 | W | Gunnison HS (CO) | 27 | Olathe HS (CO) | 0 | ? | |
| 1921 | W | Gunnison HS (CO) | 21 | Paonia HS (CO) | 0 | ? | |
| 1921 | W | Gustavus Adolphus (MN) | 20 | Gustavus Adolphus Alumni (MN) | 0 | Saint Peter, MN | |
| 1921 | L | Gustavus Adolphus (MN) | 0 | Hamline (MN) | 60 | Saint Peter, MN | |
| 1921 | W | Gustavus Adolphus (MN) | 7 | Parker College (MN) | 0 | Saint Peter, MN | |
| 1921 | L | Gustavus Adolphus (MN) | 0 | Saint Olaf (MN) | 14 | Saint Peter, MN | |
| 1921 | L | Gustavus Adolphus (MN) | 6 | Saint Thomas (MN) | 42 | Saint Peter, MN | |
| 1921 | L | Gustavus Adolphus (MN) | 0 | Macalester (MN) | 34 | Saint Paul, MN | |
| 1921 | L | Gustavus Adolphus Alumni (MN) | 0 | Gustavus Adolphus (MN) | 20 | Saint Peter, MN | |
| 1921 | L | Guthrie HS (OK) | 0 | Oklahoma City HS (OK) | 30 | ? | |
| 1921 | L | Guthrie HS (OK) | 0 | Sapulpa HS (OK) | 63 | ? | |
| 1921 | L | Guthrie HS (OK) | 0 | Tulsa Central HS (OK) | 10 | ? | |
| 1921 | L | Gwinn Legion | 0 | Northern Michigan | 29 | Marquette, MI | |
| 1921 | L | Hackensack HS (NJ) | 7 | Cliffside Park HS (NJ) | 21 | ? | |
| 1921 | L | Hackensack HS (NJ) | 14 | Clifton HS (NJ) | 21 | ? | |
| 1921 | W | Hackensack HS (NJ) | 21 | Englewood HS (NJ) | 0 | ? | |
| 1921 | W | Hackensack HS (NJ) | 40 | Leonia HS (NJ) | 0 | ? | |
| 1921 | L | Hackensack HS (NJ) | 0 | Passaic HS (NJ) | 7 | ? | |
| 1921 | L | Hackensack HS (NJ) | 0 | Paterson HS (NJ) | 7 | ? | |
| 1921 | W | Hackensack HS (NJ) | 33 | Ramsey HS (NJ) | 0 | ? | |
| 1921 | L | Hackensack HS (NJ) | 0 | Ridgewood HS (NJ) | 3 | ? | |
| 1921 | L | Hackensack HS (NJ) | 0 | Rutherford HS (NJ) | 42 | ? | |
| 1921 | L | Hackettstown HS (NJ) | 0 | Newton HS (NJ) | 59 | ? | |
| 1921 | W | Hackettstown HS (NJ) | 14 | Phillipsburg HS JV (NJ) | 0 | ? | |
| 1921 | L | Hackettstown HS (NJ) | 0 | Roxbury HS (NJ) | 21 | ? | |
| 1921 | L | Hackettstown HS (NJ) | 0 | Washington HS | 28 | ? | |
| 1921 | L | Hackettstown HS (NJ) | 0 | Washington HS | 13 | ? | |
| 1921 | L | Hackettstown HS (NJ) | 0 | Wilson HS (PA) | 14 | ? | |
| 1921 | W | Hackley School (NY) | 35 | Jersey City Kingsley HS (NJ) | 0 | ? | |
| 1921 | W | Hackley School (NY) | 48 | King School (CT) | 0 | ? | |
| 1921 | W | Hackley School (NY) | 28 | Mohegan Lake HS (NY) | 0 | ? | |
| 1921 | W | Hackley School (NY) | 33 | Morristown HS (NJ) | 0 | ? | |
| 1921 | L | Hackley School (NY) | 0 | White Plains HS (NY) | 7 | ? | |
| 1921 | W | Hackley School (NY) | 7 | Saint Paul's School (NY) | 0 | Garden City, NY | |
| 1921 | W | Hackley School (NY) | 35 | Horace Mann School (NY) | 0 | Riverdale, NY | |
| 1921 | T | Haddon Heights HS (NJ) | 0 | Burlington HS (NJ) | 0 | ? | |
| 1921 | L | Haddon Heights HS (NJ) | 0 | Collingswood HS (NJ) | 14 | ? | |
| 1921 | W | Haddon Heights HS (NJ) | 6 | Gloucester HS (NJ) | 0 | ? | |
| 1921 | W | Haddon Heights HS (NJ) | 14 | Haddon Heights HS Alumni (NJ) | 7 | ? | |
| 1921 | W | Haddon Heights HS (NJ) | 7 | Hammonton HS (NJ) | 0 | ? | |
| 1921 | L | Haddon Heights HS (NJ) | 3 | Narberth HS (PA) | 6 | ? | |
| 1921 | L | Haddon Heights HS (NJ) | 6 | Palmyra HS (NJ) | 7 | ? | |
| 1921 | L | Haddon Heights HS (NJ) | 0 | Penns Grove HS (NJ) | 7 | ? | |
| 1921 | L | Haddon Heights HS (NJ) | 12 | Salem HS (NJ) | 21 | ? | |
| 1921 | L | Haddon Heights HS (NJ) | 7 | Woodbury HS (NJ) | 21 | ? | |
| 1921 | T | Haddon Heights HS (NJ) | 0 | Woodstown HS (NJ) | 0 | ? | |
| 1921 | L | Haddon Heights HS Alumni (NJ) | 7 | Haddon Heights HS (NJ) | 14 | ? | |
| 1921 | L | Haddonfield HS (NJ) | 7 | Friends Central School (PA) | 13 | ? | |
| 1921 | L | Haddonfield HS (NJ) | 0 | Woodstown HS (NJ) | 6 | ? | |
| 1921 | L | Haines Institute (GA) | 6 | Savannah St. (GA) | 19 | ? | |
| 1921 | L | Hall | 6 | LaSalle-Peru HS (IL) | 7 | ? | |
| 1921 | L | Hallock HS (MN) | 0 | Stephen HS (MN) | 39 | ? | |
| 1921 | L | Hamilton (NY) | 0 | Amherst (MA) | 20 | Amherst, MA | |
| 1921 | L | Hamilton (NY) | 0 | Hobart (NY) | 14 | Clinton, NY | |
| 1921 | L | Hamilton (NY) | 0 | Rensselaer Tech (NY) | 49 | Troy, NY | |
| 1921 | W | Hamilton (NY) | 7 | Union (NY) | 0 | Clinton, NY | |
| 1921 | L | Hamilton (NY) | 0 | Williams (MA) | 14 | Clinton, NY | |
| 1921 | L | Hamilton (NY) | 0 | Alfred (NY) | 7 | Clinton, NY | |
| 1921 | T | Hamilton (NY) | 0 | Clarkson (NY) | 0 | Clinton, NY | |
| 1921 | L | Hamilton (NY) | 0 | Rochester (NY) | 7 | Rochester, NY | |
| 1921 | L | Hamilton HS (NY) | 0 | Herkimer HS (NY) | 28 | ? | |
| 1921 | L | Hamilton HS (OH) | 0 | Cincinnati East HS (OH) | 7 | ? | |
| 1921 | W | Hamilton HS (OH) | 41 | Springfield HS (OH) | 21 | ? | |
| 1921 | L | Hamilton Institute (NY) | 0 | Clason Military Academy (NY) | 21 | ? | |
| 1921 | L | Hamilton Institute (NY) | 0 | Concordia Prep School (NY) | 95 | ? | |
| 1921 | L | Hamlet HS (NC) | 3 | New Hanover HS (NC) | 14 | ? | |
| 1921 | W | Hamline (MN) | 60 | Gustavus Adolphus (MN) | 0 | Saint Peter, MN | |
| 1921 | W | Hamline (MN) | 21 | Macalester (MN) | 0 | Saint Paul, MN | |
| 1921 | W | Hamline (MN) | 14 | North Dakota | 0 | Saint Paul, MN | |
| 1921 | W | Hamline (MN) | 17 | Saint John's (MN) | 0 | ? | |
| 1921 | W | Hamline (MN) | 17 | Saint Thomas (MN) | 0 | Saint Paul, MN | |
| 1921 | W | Hamline (MN) | 13 | Cornell College (IA) | 2 | Mount Vernon, IA | |
| 1921 | W | Hamline (MN) | 21 | Carleton (MN) | 3 | Northfield, MN | |
| 1921 | L | Hammond HS (LA) | 0 | Baton Rouge HS (LA) | 84 | ? | |
| 1921 | W | Hammonton HS (NJ) | 35 | Atlantic City HS JV (NJ) | 0 | ? | |
| 1921 | L | Hammonton HS (NJ) | 7 | Collingswood HS (NJ) | 14 | ? | |
| 1921 | W | Hammonton HS (NJ) | 28 | Gloucester HS (NJ) | 0 | ? | |
| 1921 | L | Hammonton HS (NJ) | 0 | Haddon Heights HS (NJ) | 7 | ? | |
| 1921 | T | Hammonton HS (NJ) | 0 | Hammonton HS Alumni (NJ) | 0 | ? | |
| 1921 | W | Hammonton HS (NJ) | 34 | Moorestown HS (NJ) | 0 | ? | |
| 1921 | W | Hammonton HS (NJ) | 26 | Pleasantville HS (NJ) | 0 | ? | |
| 1921 | W | Hammonton HS (NJ) | 30 | Pleasantville HS (NJ) | 21 | ? | |
| 1921 | W | Hammonton HS (NJ) | 21 | Vineland HS (NJ) | 11 | ? | |
| 1921 | W | Hammonton HS (NJ) | 40 | Woodstown HS (NJ) | 0 | ? | |
| 1921 | T | Hammonton HS Alumni (NJ) | 0 | Hammonton HS (NJ) | 0 | ? | |
| 1921 | W | Hampden-Sydney (VA) | 7 | Richmond (VA) | 5 | Richmond, VA | |
| 1921 | W | Hampden-Sydney (VA) | 14 | Roanoke (VA) | 6 | Roanoke, VA | |
| 1921 | W | Hampden-Sydney (VA) | 21 | Union Theological Seminary (VA) | 0 | Hampden-Sydney, VA | |
| 1921 | L | Hampden-Sydney (VA) | 6 | Virginia Tech | 14 | Blacksburg, VA | |
| 1921 | W | Hampden-Sydney (VA) | 39 | Wake Forest (NC) | 14 | Norfolk, VA | |
| 1921 | L | Hampden-Sydney (VA) | 0 | Virginia Military Institute | 32 | Lexington, VA | |
| 1921 | W | Hampden-Sydney (VA) | 7 | Elon (NC) | 0 | Hampden-Sydney, VA | |
| 1921 | W | Hampden-Sydney (VA) | 21 | Randolph-Macon (VA) | 0 | Richmond, VA | |
| 1921 | T | Hampden-Sydney (VA) | 7 | Lynchburg (VA) | 7 | Lynchburg, VA | |
| 1921 | W | Hampton (VA) | 26 | Saint Paul's (VA) | 2 | ? | |
| 1921 | W | Hampton (VA) | 7 | Shaw (NC) | 6 | ? | |
| 1921 | L | Hampton (VA) | 3 | Virginia Union | 14 | Hampton, VA | |
| 1921 | L | Hampton (VA) | 0 | Howard (DC) | 34 | Hampton, VA | |
| 1921 | L | Hampton (VA) | 0 | Lincoln (PA) | 13 | Lincoln, PA | |
| 1921 | L | Hampton HS (VA) | 0 | Newport News Apprentice School (VA) | 19 | ? | |
| 1921 | L | Hampton HS (VA) | 6 | Newport News HS (VA) | 7 | ? | |
| 1921 | L | Hancock HS (MI) | 0 | Calumet HS (MI) | 7 | ? | |
| 1921 | L | Hancock HS (MI) | 0 | Calumet HS (MI) | 41 | ? | |
| 1921 | L | Hancock HS (MN) | 6 | Glenwood HS (MN) | 13 | ? | |
| 1921 | L | Hancock HS (MN) | 0 | Montevideo HS (MN) | 54 | ? | |
| 1921 | L | Hancock HS (MN) | 0 | Willmar HS (MN) | 26 | ? | |
| 1921 | L | Hanford HS (CA) | 0 | Fresno HS (CA) | 19 | ? | |
| 1921 | L | Hanford HS (CA) | 13 | Selma HS (CA) | 35 | ? | |
| 1921 | W | Hannibal HS (MO) | 23 | Carrollton HS (MO) | 0 | ? | |
| 1921 | W | Hannibal HS (MO) | 14 | Jacksonville HS (IL) | 0 | ? | |
| 1921 | W | Hannibal HS (MO) | 70 | Monroe City HS (MO) | 0 | ? | |
| 1921 | W | Hannibal HS (MO) | 28 | Palmyra HS (MO) | 0 | ? | |
| 1921 | L | Hannibal HS (MO) | 0 | Pittsfield HS (IL) | 41 | ? | |
| 1921 | T | Hannibal HS (MO) | 7 | Quincy HS (IL) | 7 | ? | |
| 1921 | W | Hannibal HS (MO) | 33 | Shelbina HS (MO) | 0 | ? | |
| 1921 | L | Hanover (IN) | 0 | Butler (IN) | 122 | Indianapolis, IN | |
| 1921 | W | Hanover (IN) | 3 | Dayton (OH) | 0 | ? | |
| 1921 | L | Hanover (IN) | 0 | Franklin (IN) | 7 | ? | |
| 1921 | L | Hanover (IN) | 8 | Louisville (KY) | 19 | Louisville, KY | Hanover Forfeits |
| 1921 | L | Hanover (IN) | 17 | Rose-Hulman Tech (IN) | 49 | ? | |
| 1921 | L | Hanover (IN) | 7 | Earlham (IN) | 14 | Hanover, IN | |
| 1921 | L | Hanover (IN) | 0 | Xavier (OH) | 34 | Hanover, IN | |
| 1921 | T | Hanover HS (PA) | 6 | Wilkes-Barre HS (PA) | 6 | ? | |
| 1921 | L | Hardin-Simmons (TX) | 0 | Austin (TX) | 7 | Sherman, TX | |
| 1921 | W | Hardin-Simmons (TX) | 24 | Daniel Baker (TX) | 21 | Brownwood, TX | |
| 1921 | L | Hardin-Simmons (TX) | 0 | Howard Payne (TX) | 28 | Abilene, TX | |
| 1921 | W | Hardin-Simmons (TX) | 35 | New Mexico Military Institute | 0 | Abilene, TX | |
| 1921 | L | Hardin-Simmons (TX) | 0 | Phillips (OK) | 9 | Abilene, TX | |
| 1921 | W | Hardin-Simmons (TX) | 7 | Trinity (TX) | 0 | Waxahachie, TX | |
| 1921 | W | Hardin-Simmons (TX) | 10 | Texas Christian | 7 | Abilene, TX | |
| 1921 | W | Hardin-Simmons (TX) | 28 | West Texas A&M | 0 | Abilene, TX | |
| 1921 | W | Hardin-Simmons (TX) | 6 | North Texas | 0 | Denton, TX | |
| 1921 | L | Hardin-Simmons (TX) | 0 | Baylor (TX) | 21 | Waco, TX | |
| 1921 | L | Harford Bulkeley HS (CT) | 6 | Bridgeport HS (CT) | 18 | ? | |
| 1921 | L | Harford Bulkeley HS (CT) | 0 | New London Vocational HS (CT) | 3 | ? | |
| 1921 | W | Harford Bulkeley HS (CT) | 19 | New London Vocational HS (CT) | 0 | ? | |
| 1921 | L | Harford Bulkeley HS (CT) | 0 | Westerly HS (RI) | 1 | ? | |
| 1921 | W | Harford Bulkeley HS (CT) | 7 | Westerly HS (RI) | 0 | ? | |
| 1921 | L | Harlowton HS (MT) | 0 | Fergus County HS (MT) | 27 | ? | |
| 1921 | L | Harlowton HS (MT) | 0 | Fergus County HS (MT) | 70 | ? | |
| 1921 | W | Harlowton HS (MT) | 133 | Roundup HS (MT) | 0 | ? | |
| 1921 | W | Harlowton HS (MT) | 7 | Roundup HS (MT) | 6 | ? | |
| 1921 | W | Harlowton HS (MT) | 52 | Stanford HS (MT) | 0 | ? | |
| 1921 | W | Harlowton HS (MT) | 26 | Winnett HS (MT) | 13 | ? | |
| 1921 | W | Harlowton HS (MT) | 35 | Winnett HS (MT) | 7 | ? | |
| 1921 | W | Harrisburg Academy (PA) | 21 | Elizabethville HS (PA) | 0 | ? | |
| 1921 | L | Harrisburg Academy (PA) | 0 | Franklin & Marshall Academy (PA) | 35 | ? | |
| 1921 | L | Harrisburg Academy (PA) | 0 | Gettysburg Academy (PA) | 21 | ? | |
| 1921 | W | Harrisburg Academy (PA) | 23 | Gettysburg HS (PA) | 20 | ? | |
| 1921 | W | Harrisburg Academy (PA) | 14 | Lykens HS (PA) | 7 | ? | |
| 1921 | L | Harrisburg Academy (PA) | 7 | Saint James Prep School (MD) | 21 | ? | |
| 1921 | L | Harrisburg Academy (PA) | 7 | Schuylkill College (PA) | 21 | ? | |
| 1921 | W | Harrisburg Academy (PA) | 21 | York HS (PA) | 0 | ? | |
| 1921 | L | Harrisburg HS (IL) | 6 | Murphysboro HS (IL) | 27 | ? | |
| 1921 | L | Harrisburg HS (IL) | 17 | Murphysboro HS (IL) | 20 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 63 | Bethlehem HS (PA) | 21 | ? | |
| 1921 | L | Harrisburg Tech HS (PA) | 6 | Greensburg HS (PA) | 21 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 69 | Milton HS (PA) | 0 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 14 | Moravian Prep | 7 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 12 | Mount Carmel HS (PA) | 0 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 70 | Perkiomen Seminary (PA) | 0 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 49 | Scranton Tech HS (PA) | 0 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 13 | Steelton HS (PA) | 0 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 38 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | W | Harrisburg Tech HS (PA) | 91 | Wilkes-Barre HS (PA) | 0 | ? | |
| 1921 | L | Harrisburg YMCA (PA) | 7 | Lincoln (PA) | 13 | ? | |
| 1921 | W | Harrisburg YMCA (PA) | 52 | Morgan St. (MD) | 0 | Harrisburg, PA | |
| 1921 | T | Harrison HS | 0 | Chicago Englewood HS (IL) | 0 | ? | |
| 1921 | L | Harrison Tech | 0 | Freeport HS (IL) | 7 | ? | |
| 1921 | L | Harrison Tech | 0 | Mooseheart HS (IL) | 55 | ? | |
| 1921 | W | Hartford All-Stars (CT) | 13 | New London Submarine Base (CT) | 0 | ? | |
| 1921 | L | Hartford All-Stars (CT) | 0 | New London Submarine Base (CT) | 14 | ? | |
| 1921 | L | Hartford HS (CT) | 0 | New Britain HS (CT) | 9 | ? | |
| 1921 | W | Hartford HS (CT) | 12 | Stamford HS (CT) | 7 | ? | |
| 1921 | W | Harvard (MA) | 10 | Boston (MA) | 0 | Cambridge, MA | |
| 1921 | L | Harvard (MA) | 0 | Centre (KY) | 6 | Cambridge, MA | |
| 1921 | W | Harvard (MA) | 10 | Georgia | 7 | Cambridge, MA | |
| 1921 | W | Harvard (MA) | 16 | Middlebury (VT) | 0 | Cambridge, MA | |
| 1921 | T | Harvard (MA) | 21 | Penn St. | 21 | Cambridge, MA | |
| 1921 | W | Harvard (MA) | 10 | Yale (CT) | 3 | Cambridge, MA | |
| 1921 | W | Harvard (MA) | 3 | Holy Cross (MA) | 0 | Cambridge, MA | |
| 1921 | L | Harvard (MA) | 3 | Princeton (NJ) | 10 | Princeton, NJ | |
| 1921 | W | Harvard (MA) | 19 | Indiana | 0 | Cambridge, MA | |
| 1921 | W | Harvard (MA) | 9 | Brown (RI) | 7 | Cambridge, MA | |
| 1921 | W | Harvard Freshmen (MA) | 7 | Worcester Academy (MA) | 0 | ? | |
| 1921 | L | Harvard HS (NE) | 0 | North Platte HS (NE) | 42 | ? | |
| 1921 | L | Harvard JV (MA) | 0 | New London Submarine Base (CT) | 7 | ? | |
| 1921 | W | Harvard Military School (CA) | 33 | Coronado HS (CA) | 12 | ? | |
| 1921 | W | Harvard Military School (CA) | 53 | Lancaster HS | 0 | ? | |
| 1921 | L | Harvard Military School (CA) | 0 | Santa Ana HS (CA) | 17 | ? | |
| 1921 | W | Harvard Military School (CA) | 7 | Santa Barbara HS (CA) | 3 | ? | |
| 1921 | L | Hasbrouck Heights HS (NJ) | 0 | Clifton HS (NJ) | 28 | ? | |
| 1921 | L | Haskell Indian Nations (KS) | 7 | Des Moines (IA) | 24 | Kansas City, MO | |
| 1921 | W | Haskell Indian Nations (KS) | 14 | Friends (KS) | 7 | Lawrence, KS | |
| 1921 | W | Haskell Indian Nations (KS) | 89 | Kansas Wesleyan | 0 | Lawrence, KS | |
| 1921 | L | Haskell Indian Nations (KS) | 0 | Nebraska | 41 | Lincoln, NE | |
| 1921 | W | Haskell Indian Nations (KS) | 14 | Pittsburg St. (KS) | 0 | Pittsburg, KS | |
| 1921 | W | Haskell Indian Nations (KS) | 14 | Texas Christian | 0 | Fort Worth, TX | |
| 1921 | W | Haskell Indian Nations (KS) | 21 | Tulsa (OK) | 0 | Kansas City, MO | |
| 1921 | L | Haskell Indian Nations (KS) | 2 | Marquette (WI) | 41 | Milwaukee, WI | |
| 1921 | L | Haskell Indian Nations (KS) | 7 | Notre Dame (IN) | 42 | Notre Dame, IN | |
| 1921 | W | Hastings (NE) | 73 | American Legion | 0 | ? | |
| 1921 | T | Hastings (NE) | 0 | Doane (NE) | 0 | ? | |
| 1921 | W | Hastings (NE) | 14 | Grand Island College (NE) | 7 | ? | |
| 1921 | W | Hastings (NE) | 21 | Nebraska Central | 6 | ? | |
| 1921 | L | Hastings (NE) | 0 | Nebraska Wesleyan | 14 | Hastings, NE | |
| 1921 | T | Hastings (NE) | 7 | Nebraska-Kearney | 7 | ? | |
| 1921 | L | Hastings (NE) | 7 | Peru St. (NE) | 32 | Peru, NE | |
| 1921 | L | Hastings (NE) | 0 | York (NE) | 7 | ? | York Forfeits? |
| 1921 | W | Hastings (NE) | 17 | Cotner (NE) | 0 | Hastings, NE | |
| 1921 | L | Hastings HS (MI) | 0 | Marshall HS (MI) | 28 | ? | |
| 1921 | W | Havana AC (Cuba) | 14 | Mississippi | 0 | Havana, Cuba | Bacardi Bowl |
| 1921 | L | Haverford (PA) | 0 | Delaware | 13 | Haverford, PA | |
| 1921 | L | Haverford (PA) | 0 | Franklin & Marshall (PA) | 35 | Haverford, PA | |
| 1921 | L | Haverford (PA) | 0 | Swarthmore (PA) | 55 | Swarthmore, PA | |
| 1921 | L | Haverford (PA) | 7 | Ursinus (PA) | 13 | Collegeville, PA | |
| 1921 | L | Haverford (PA) | 3 | Johns Hopkins (MD) | 28 | Baltimore, MD | |
| 1921 | T | Haverford (PA) | 0 | Stevens Tech (NJ) | 0 | Hoboken, NJ | |
| 1921 | W | Haverford (PA) | 6 | Trinity (CT) | 0 | Haverford, PA | |
| 1921 | W | Haverford College Grammer School (PA) | 7 | Episcopal Academy (PA) | 2 | ? | |
| 1921 | L | Haverford College Grammer School (PA) | 0 | Frankford HS (PA) | 7 | ? | |
| 1921 | W | Haverford College Grammer School (PA) | 6 | Friends Central School (PA) | 0 | ? | |
| 1921 | W | Haverford College Grammer School (PA) | 14 | Germantown Academy (PA) | 7 | ? | |
| 1921 | W | Haverford College Grammer School (PA) | 14 | Hill School (PA) | 7 | ? | |
| 1921 | L | Haverford College Grammer School (PA) | 7 | Penn Charter School (PA) | 13 | ? | |
| 1921 | W | Haverford College Grammer School (PA) | 33 | Saint Luke's School (PA) | 14 | ? | |
| 1921 | L | Haverford College Grammer School JV (PA) | 6 | Saint Luke's School (PA) | 16 | ? | |
| 1921 | L | Haverford HS (PA) | 0 | Darby HS (PA) | 13 | ? | |
| 1921 | L | Haverford HS (PA) | 0 | Media HS (PA) | 6 | ? | |
| 1921 | W | Haverhill HS (MA) | 21 | Brockton HS (MA) | 13 | ? | |
| 1921 | W | Haverhill HS (MA) | 21 | Brookline HS (MA) | 7 | ? | |
| 1921 | W | Haverhill HS (MA) | 40 | Durfee School | 0 | ? | |
| 1921 | W | Haverhill HS (MA) | 14 | Lawrence HS (MA) | 6 | ? | |
| 1921 | W | Haverhill HS (MA) | 21 | Lowell HS (MA) | 0 | ? | |
| 1921 | W | Haverhill HS (MA) | 7 | Lynn Classical HS (MA) | 0 | ? | |
| 1921 | T | Haverhill HS (MA) | 7 | Malden HS (MA) | 7 | ? | |
| 1921 | W | Haverhill HS (MA) | 28 | Manchester HS (MA) | 14 | ? | |
| 1921 | W | Haverhill HS (MA) | 28 | Manchester HS (NH) | 14 | ? | |
| 1921 | W | Haverhill HS (MA) | 32 | New Bedford HS (MA) | 0 | ? | |
| 1921 | W | Haverhill HS (MA) | 19 | Saint John's Prep (MA) | 0 | ? | |
| 1921 | T | Haverhill HS (MA) | 0 | Waltham HS (MA) | 0 | ? | |
| 1921 | W | Haverling | 13 | Cook Academy (NY) | 6 | ? | |
| 1921 | T | Hawaii | 0 | Hawaii Marines | 0 | Honolulu, HI | |
| 1921 | W | Hawaii | 29 | Hawaii National Guard | 7 | Honolulu, HI | |
| 1921 | L | Hawaii | 0 | Oregon | 47 | Honolulu, HI | |
| 1921 | T | Hawaii | 12 | Outrigger Canoe Club (HI) | 12 | Honolulu, HI | |
| 1921 | W | Hawaii | 7 | Honolulu Town Team (HI) | 0 | Honolulu, HI | |
| 1921 | L | Hawaii | 0 | Pearl Harbor Navy (HI) | 35 | Honolulu, HI | |
| 1921 | L | Hawaii | 6 | Honolulu AC (HI) | 7 | Honolulu, HI | |
| 1921 | W | Hawaii | 13 | Palama | 6 | Honolulu, HI | |
| 1921 | T | Hawaii Marines | 0 | Hawaii | 0 | Honolulu, HI | |
| 1921 | L | Hawaii National Guard | 7 | Hawaii | 29 | Honolulu, HI | |
| 1921 | W | Hayward HS (CA) | 33 | Potter School (CA) | 6 | ? | |
| 1921 | L | Hazleton HS (PA) | 0 | Mount Carmel HS (PA) | 47 | ? | |
| 1921 | L | Hector HS (MN) | 13 | Willmar HS (MN) | 16 | ? | |
| 1921 | L | Hedding (IL) | 0 | Carthage (WI) | 45 | Carthage, IL | |
| 1921 | L | Hedding (IL) | 0 | Knox (IL) | 34 | Galesburg, IL | |
| 1921 | W | Hedding (IL) | 54 | Lincoln College (IL) | 6 | Abingdon, IL | |
| 1921 | L | Hedding (IL) | 0 | Western Illinois | 14 | Abingdon, IL | |
| 1921 | L | Hedding (IL) | 0 | Bradley (IL) | 62 | Peoria, IL | |
| 1921 | L | Hedding (IL) | 0 | Eureka (IL) | 37 | Abingdon, IL | |
| 1921 | W | Hedding (IL) | 21 | Culver-Stockton (MO) | 4 | Abingdon, IL | |
| 1921 | W | Hedding (IL) | 7 | Quincy (IL) | 6 | Quincy, IL | |
| 1921 | L | Heidelberg (OH) | 0 | Akron (OH) | 14 | Akron, OH | |
| 1921 | L | Heidelberg (OH) | 7 | Case Institute of Technology (OH) | 14 | Tiffin, OH | |
| 1921 | T | Heidelberg (OH) | 0 | Defiance (OH) | 0 | Tiffin, OH | |
| 1921 | L | Heidelberg (OH) | 0 | Denison (OH) | 7 | Granville, OH | |
| 1921 | L | Heidelberg (OH) | 2 | Otterbein (OH) | 13 | ? | |
| 1921 | L | Heidelberg (OH) | 0 | Western Reserve (OH) | 29 | Cleveland, OH | |
| 1921 | L | Heidelberg (OH) | 7 | Ohio Wesleyan | 26 | Delaware, OH | |
| 1921 | L | Heidelberg (OH) | 0 | Ohio Northern | 13 | Ada, OH | |
| 1921 | T | Hempstead HS (NY) | 0 | Adelphi Academy (NY) | 0 | ? | |
| 1921 | T | Hempstead HS (NY) | 0 | Jamaica HS (NY) | 0 | ? | |
| 1921 | L | Henderson HS (KY) | 0 | Louisville HS (KY) | 94 | ? | |
| 1921 | L | Henderson HS (NC) | 0 | Durham HS (NC) | 79 | ? | |
| 1921 | L | Henderson HS (NC) | 6 | Durham HS (NC) | 34 | ? | |
| 1921 | L | Henderson St. (AR) | 7 | Arkansas Tech | 21 | Russellville, AR | |
| 1921 | L | Henderson St. (AR) | 7 | Austin (TX) | 14 | Sherman, TX | |
| 1921 | L | Henderson St. (AR) | 0 | Ouachita Baptist (AR) | 14 | Arkadelphia, AR | |
| 1921 | W | Henderson St. (AR) | 37 | Southern Arkansas | 7 | Arkadelphia, AR | |
| 1921 | W | Henderson St. (AR) | 29 | Arkansas College | 7 | Arkadelphia, AR | |
| 1921 | T | Henderson St. (AR) | 7 | Ozarks (AR) | 7 | Clarksville, AR | |
| 1921 | W | Henderson St. (AR) | 21 | Hendrix (AR) | 7 | Conway, AR | Morning Game |
| 1921 | W | Henderson St. (AR) | 9 | Hendrix (AR) | 7 | Conway, AR | Afternoon Game |
| 1921 | L | Henderson St. JV (AR) | 6 | Pine Bluff HS (AR) | 7 | ? | |
| 1921 | W | Hendrix (AR) | 13 | Arkansas College | 0 | Batesville, AR | |
| 1921 | W | Hendrix (AR) | 20 | Ozarks (AR) | 0 | Clarksville, AR | |
| 1921 | L | Hendrix (AR) | 0 | Arkansas | 28 | Fayetteville, AR | |
| 1921 | L | Hendrix (AR) | 7 | Henderson St. (AR) | 21 | Conway, AR | Morning Game |
| 1921 | L | Hendrix (AR) | 7 | Henderson St. (AR) | 9 | Conway, AR | Afternoon Game |
| 1921 | L | Hendrix (AR) | 0 | Ouachita Baptist (AR) | 35 | Conway, AR | |
| 1921 | T | Hendrix College Academy (AR) | 7 | Little Rock HS (AR) | 7 | ? | |
| 1921 | L | Hendrix JV (AR) | 7 | Arkansas-Monticello | 27 | Monticello, AR | |
| 1921 | L | Herkimer HS (NY) | 0 | Cazenovia Seminary (NY) | 28 | ? | |
| 1921 | W | Herkimer HS (NY) | 33 | Clinton HS (NY) | 0 | ? | |
| 1921 | W | Herkimer HS (NY) | 48 | Dolgeville HS (NY) | 0 | ? | |
| 1921 | W | Herkimer HS (NY) | 28 | Hamilton HS (NY) | 0 | ? | |
| 1921 | T | Herkimer HS (NY) | 14 | Ilion HS (NY) | 14 | ? | |
| 1921 | L | Herkimer HS (NY) | 0 | Oneida HS (NY) | 19 | ? | |
| 1921 | L | Herkimer HS (NY) | 0 | Rome Free Academy (NY) | 13 | ? | |
| 1921 | W | Herkimer HS (NY) | 14 | Utica Free Academy (NY) | 9 | ? | |
| 1921 | L | Hibbing HS (MN) | 0 | Alexandria HS (MN) | 28 | ? | |
| 1921 | L | Hibbing HS (MN) | 0 | Coleraine HS (MN) | 13 | ? | |
| 1921 | L | Highland Falls HS (NY) | 7 | Middletown HS (NY) | 61 | ? | |
| 1921 | L | Highland Falls HS (NY) | 0 | Nyack HS (NY) | 46 | ? | |
| 1921 | L | Highland Park HS (MI) | 0 | Detroit Northeastern HS (MI) | 7 | ? | |
| 1921 | L | Highland Park HS (MI) | 6 | Flint Central HS (MI) | 21 | ? | |
| 1921 | L | Highlands HS | 0 | Cincinnati East HS (OH) | 74 | ? | |
| 1921 | L | Hill School (PA) | 7 | Haverford College Grammer School (PA) | 14 | ? | |
| 1921 | W | Hill School (PA) | 16 | Hotchkiss Academy (CT) | 0 | ? | |
| 1921 | L | Hill School (PA) | 7 | Lawrenceville School (NJ) | 10 | ? | |
| 1921 | W | Hill School (PA) | 14 | Princeton Prep School (NJ) | 0 | ? | |
| 1921 | W | Hill School (PA) | 14 | Tome Institute (MD) | 7 | ? | |
| 1921 | W | Hill School (PA) | 34 | Williamson Trade School (PA) | 0 | ? | |
| 1921 | W | Hill School (PA) | 42 | Perkiomen Seminary (PA) | 0 | Pottstown, PA | |
| 1921 | L | Hillsboro HS (ND) | 0 | Moorhead HS (MN) | 69 | ? | |
| 1921 | W | Hillsdale (MI) | 1 | Adrian (MI) | 0 | ? | |
| 1921 | L | Hillsdale (MI) | 0 | Albion (MI) | 14 | Albion, MI | |
| 1921 | W | Hillsdale (MI) | 7 | Assumption College (ON) | 2 | ? | |
| 1921 | W | Hillsdale (MI) | 14 | Central Michigan | 10 | Mount Pleasant, MI | |
| 1921 | W | Hillsdale (MI) | 35 | Defiance (OH) | 0 | Hillsdale, MI | |
| 1921 | L | Hillsdale (MI) | 0 | Grand Rapids JC (MI) | 13 | ? | |
| 1921 | W | Hillsdale (MI) | 34 | Hope (MI) | 0 | ? | |
| 1921 | W | Hillsdale (MI) | 21 | Olivet (MI) | 13 | ? | |
| 1921 | W | Hillsdale (MI) | 14 | Alma (MI) | 0 | ? | |
| 1921 | L | Hillsdale (MI) | 7 | Eastern Michigan | 13 | Hillsdale, MI | |
| 1921 | W | Hillsdale HS (MI) | 21 | Albion HS (MI) | 0 | ? | |
| 1921 | W | Hillsdale HS (MI) | 14 | Marshall HS (MI) | 0 | ? | |
| 1921 | W | Hinton HS (WV) | 21 | A.I.C. | 6 | ? | |
| 1921 | L | Hinton HS (WV) | 0 | Charleston HS (WV) | 34 | ? | |
| 1921 | W | Hinton HS (WV) | 7 | Concord (WV) | 0 | ? | |
| 1921 | L | Hinton HS (WV) | 0 | Covington HS | 20 | ? | |
| 1921 | L | Hinton HS (WV) | 7 | East Bank HS (WV) | 14 | ? | |
| 1921 | W | Hinton HS (WV) | 81 | Oak Hill HS (WV) | 0 | ? | |
| 1921 | W | Hinton HS (WV) | 19 | Ronceverte HS (WV) | 13 | ? | |
| 1921 | L | Hiram (OH) | 0 | Case Institute of Technology (OH) | 14 | Cleveland, OH | |
| 1921 | W | Hiram (OH) | 14 | John Carroll (OH) | 0 | Cleveland, OH | |
| 1921 | L | Hiram (OH) | 6 | Oberlin (OH) | 38 | Hiram, OH | |
| 1921 | L | Hiram (OH) | 0 | Ohio Northern | 35 | Hiram, OH | |
| 1921 | T | Hiram (OH) | 0 | Otterbein (OH) | 0 | Hiram, OH | |
| 1921 | L | Hiram (OH) | 0 | Wooster (OH) | 14 | Wooster, OH | |
| 1921 | L | Hiram (OH) | 0 | Geneva (PA) | 1 | Beaver Falls, PA | Hiram Forfeits |
| 1921 | W | Hiram (OH) | 6 | Akron (OH) | 0 | Hiram, OH | |
| 1921 | T | Hiram (OH) | 0 | Kenyon (OH) | 0 | Hiram, OH | |
| 1921 | W | Hitchcock Military Academy (CA) | 35 | Potter School (CA) | 7 | ? | |
| 1921 | W | Hobart (NY) | 24 | Clarkson (NY) | 0 | Geneva, NY | |
| 1921 | W | Hobart (NY) | 14 | Hamilton (NY) | 0 | Clinton, NY | |
| 1921 | W | Hobart (NY) | 14 | Rochester (NY) | 0 | Rochester, NY | |
| 1921 | L | Hobart (NY) | 0 | Syracuse (NY) | 35 | Syracuse, NY | |
| 1921 | W | Hobart (NY) | 21 | Union (NY) | 7 | Schenectady, NY | |
| 1921 | L | Hobart (NY) | 0 | New York (NY) | 26 | New York, NY | Ohio Field |
| 1921 | L | Hobart (NY) | 0 | Rensselaer Tech (NY) | 21 | Troy, NY | |
| 1921 | W | Hobart (NY) | 10 | Niagara (NY) | 7 | Geneva, NY | |
| 1921 | W | Hobart (NY) | 37 | Buffalo (NY) | 0 | Geneva, NY | |
| 1921 | W | Hoboken Stevens Prep HS (NJ) | 18 | Jersey City Kingsley HS (NJ) | 6 | ? | |
| 1921 | W | Hoboken Stevens Prep HS (NJ) | 13 | Leonia HS (NJ) | 0 | ? | |
| 1921 | W | Hoboken Stevens Prep HS (NJ) | 1 | Mamaroneck HS (NY) | 0 | ? | |
| 1921 | L | Hoboken Stevens Prep HS (NJ) | 0 | Montclair Military Academy (NJ) | 40 | ? | |
| 1921 | L | Hoboken Stevens Prep HS (NJ) | 7 | New York Military Academy | 28 | ? | |
| 1921 | L | Hoboken Stevens Prep HS (NJ) | 0 | Newark Academy (NJ) | 33 | ? | |
| 1921 | L | Hoboken Stevens Prep HS (NJ) | 0 | Newark Academy (NJ) | 30 | ? | |
| 1921 | W | Hoboken Stevens Prep HS (NJ) | 18 | Union City Emerson HS (NJ) | 7 | ? | |
| 1921 | L | Holbrook HS (AZ) | 0 | Northern Arizona | 6 | Holbrook, AZ | |
| 1921 | W | Holbrook HS (AZ) | 18 | Northern Arizona | 14 | Flagstaff, AZ | |
| 1921 | L | Holderness HS (NH) | 0 | Tilton Seminary (NH) | 19 | ? | |
| 1921 | L | Holdrege HS (NE) | 7 | Alma HS (NE) | 48 | ? | |
| 1921 | L | Holdrege HS (NE) | 0 | Alma HS (NE) | 14 | ? | |
| 1921 | W | Holdrege HS (NE) | 86 | Beaver City HS (NE) | 0 | ? | |
| 1921 | L | Holdrege HS (NE) | 6 | McCook HS (NE) | 62 | ? | |
| 1921 | W | Holdrege HS (NE) | 33 | Minden HS (NE) | 0 | ? | |
| 1921 | W | Holdrege HS (NE) | 13 | Minden HS (NE) | 0 | ? | |
| 1921 | L | Holdrege HS (NE) | 0 | Nebraska School of Agriculture | 36 | ? | |
| 1921 | W | Holdrege HS (NE) | 13 | Orleans HS (NE) | 6 | ? | |
| 1921 | W | Holdrege HS (NE) | 36 | Orleans HS (NE) | 0 | ? | |
| 1921 | W | Holdrege HS (NE) | 27 | Oxford HS (NE) | 0 | ? | |
| 1921 | W | Holland HS (MI) | 7 | Grand Rapids Union HS (MI) | 0 | ? | |
| 1921 | L | Hollis FC | 6 | Jamaica HS (NY) | 26 | ? | |
| 1921 | L | Hollister HS (CA) | 7 | Salinas HS (CA) | 14 | ? | |
| 1921 | L | Hollister HS (CA) | 9 | Santa Cruz HS (CA) | 21 | ? | |
| 1921 | W | Hollister HS (CA) | 21 | William Warren Military School (CA) | 7 | ? | |
| 1921 | W | Hollister JC (CA) | 30 | San Jose St. (CA) | 14 | ? | |
| 1921 | L | Holtville HS (CA) | 0 | El Centro Central HS (CA) | 43 | ? | |
| 1921 | L | Holtville HS (CA) | 6 | El Centro Central HS (CA) | 20 | ? | |
| 1921 | W | Holy Cross (MA) | 28 | Bates (ME) | 0 | Worcester, MA | |
| 1921 | W | Holy Cross (MA) | 41 | Boston College (MA) | 0 | Boston, MA | |
| 1921 | L | Holy Cross (MA) | 7 | Georgetown (DC) | 28 | Worcester, MA | |
| 1921 | L | Holy Cross (MA) | 7 | New Hampshire | 13 | Manchester, NH | |
| 1921 | L | Holy Cross (MA) | 0 | Harvard (MA) | 3 | Cambridge, MA | |
| 1921 | W | Holy Cross (MA) | 44 | Canisius (NY) | 0 | Worcester, MA | |
| 1921 | W | Holy Cross (MA) | 12 | Springfield (MA) | 0 | Springfield, MA | |
| 1921 | W | Holy Cross (MA) | 14 | Colby (ME) | 0 | Worcester, MA | |
| 1921 | W | Holy Cross B Team (MA) | 19 | Providence (RI) | 7 | Providence, RI | Hope High School |
| 1921 | L | Holyoke HS (CO) | 0 | Nebraska School of Agriculture | 103 | ? | |
| 1921 | L | Holyoke HS (CO) | 14 | Sterling HS (CO) | 16 | ? | |
| 1921 | L | Holyoke HS (CO) | 0 | Yuma County HS (CO) | 27 | ? | |
| 1921 | L | Holyoke HS (MA) | 0 | Ansonia HS (CT) | 26 | ? | |
| 1921 | L | Holyoke HS (MA) | 0 | New Britain HS (CT) | 6 | ? | |
| 1921 | L | Homer HS (MI) | 0 | Marshall HS (MI) | 41 | ? | |
| 1921 | L | Homestead HS (PA) | 0 | Duquesne HS (PA) | 7 | ? | |
| 1921 | W | Homestead HS (PA) | 13 | North Braddock HS (PA) | 0 | ? | |
| 1921 | L | Homestead HS (PA) | 0 | Wilkinsburg HS (PA) | 7 | ? | |
| 1921 | W | Honolulu AC (HI) | 7 | Hawaii | 6 | Honolulu, HI | |
| 1921 | L | Honolulu Town Team (HI) | 0 | Hawaii | 7 | Honolulu, HI | |
| 1921 | L | Hooker HS (OK) | 0 | Oklahoma Panhandle St. | 6 | Goodwell, OK | Oklahoma Panhandle St. won - score unknown |
| 1921 | L | Hoopeston HS (IL) | 2 | Danville HS (IL) | 14 | ? | |
| 1921 | T | Hoosac School (NY) | 0 | Albany Academy (NY) | 0 | ? | |
| 1921 | W | Hoosac School (NY) | 7 | Bennington HS (NY) | 0 | ? | |
| 1921 | L | Hoosac School (NY) | 7 | Green Mountain Pros | 13 | ? | |
| 1921 | L | Hoosac School (NY) | 6 | Williamstown HS (NY) | 19 | ? | |
| 1921 | L | Hoosac School (NY) | 0 | Williamstown HS (NY) | 26 | ? | |
| 1921 | L | Hoosick Falls HS (NY) | 0 | Albany Academy (NY) | 26 | ? | |
| 1921 | L | Hope (MI) | 0 | Alma (MI) | 32 | ? | |
| 1921 | L | Hope (MI) | 3 | Grand Rapids JC (MI) | 7 | ? | |
| 1921 | L | Hope (MI) | 0 | Hillsdale (MI) | 34 | ? | |
| 1921 | L | Hope (MI) | 0 | Western Michigan | 65 | Kalamazoo, MI | |
| 1921 | W | Hope Street HS (RI) | 7 | Moses Brown School (RI) | 0 | ? | |
| 1921 | W | Hopkins Grammar School (CT) | 22 | Commercial HS | 0 | ? | |
| 1921 | W | Hopkins Grammar School (CT) | 19 | Crosby HS (CT) | 12 | ? | |
| 1921 | W | Hopkins Grammar School (CT) | 6 | New Haven HS (CT) | 0 | ? | |
| 1921 | L | Hopkins Grammar School (CT) | 2 | Roxbury HS (MA) | 14 | ? | |
| 1921 | L | Hopkins Grammar School (CT) | 2 | Roxbury School (CT) | 14 | ? | |
| 1921 | W | Hopkins Grammar School (CT) | 3 | Westminster School (CT) | 0 | ? | |
| 1921 | L | Hopkins Grammar School (CT) | 0 | Williston Seminary (MA) | 7 | ? | |
| 1921 | W | Hopkins Prep (CT) | 19 | Crosby HS (CT) | 12 | ? | |
| 1921 | L | Hoquiam HS (WA) | 0 | Chehalis HS (WA) | 7 | ? | |
| 1921 | L | Horace Mann School (NY) | 0 | City College of New York Freshmen | 34 | ? | |
| 1921 | T | Horace Mann School (NY) | 0 | Marquand School (NY) | 0 | ? | |
| 1921 | W | Horace Mann School (NY) | 14 | Mount Pleasant HS (NY) | 0 | ? | |
| 1921 | W | Horace Mann School (NY) | 38 | Pleasantville HS (NJ) | 6 | ? | |
| 1921 | L | Horace Mann School (NY) | 0 | Hackley School (NY) | 35 | Riverdale, NY | |
| 1921 | L | Horicon HS (WI) | 0 | Wayland Academy (WI) | 46 | ? | |
| 1921 | L | Hot Springs HS (AR) | 0 | Pine Bluff HS (AR) | 48 | ? | |
| 1921 | L | Hot Springs HS (SD) | 0 | Edgemont HS (SD) | 12 | ? | |
| 1921 | L | Hot Springs HS (SD) | 0 | Lead HS (SD) | 33 | ? | |
| 1921 | W | Hot Springs HS (SD) | 7 | Lead HS (SD) | 0 | ? | |
| 1921 | L | Hotchkiss Academy (CT) | 0 | Columbia Freshmen (NY) | 21 | ? | |
| 1921 | L | Hotchkiss Academy (CT) | 0 | Hill School (PA) | 16 | ? | |
| 1921 | W | Hotchkiss Academy (CT) | 13 | Kent School (CT) | 9 | ? | |
| 1921 | L | Hotchkiss Academy (CT) | 6 | Taft School (CT) | 20 | ? | |
| 1921 | T | Hotchkiss Academy (CT) | 7 | Trinity Freshmen (CT) | 7 | ? | |
| 1921 | L | Hotchkiss Academy (CT) | 0 | Yale Freshmen (CT) | 40 | Lakeville, CT | |
| 1921 | L | Hotchkiss HS (CO) | 0 | Gunnison HS (CO) | 1 | ? | Hotchkiss HS Forfeits |
| 1921 | L | Houghton HS (MI) | 0 | Calumet HS (MI) | 37 | ? | |
| 1921 | L | Houghton HS (MI) | 0 | Calumet HS (MI) | 25 | ? | |
| 1921 | L | Houma HS (LA) | 0 | Baton Rouge HS (LA) | 55 | ? | |
| 1921 | T | Houston Central HS (TX) | 0 | Beaumont HS (TX) | 0 | ? | |
| 1921 | L | Houston Heights HS (TX) | 0 | Beaumont HS (TX) | 10 | ? | |
| 1921 | L | Howard (DC) | 7 | Lincoln (PA) | 13 | Philadelphia, PA | |
| 1921 | W | Howard (DC) | 19 | Lynchburg (VA) | 0 | ? | |
| 1921 | W | Howard (DC) | 33 | North Carolina A&T | 0 | ? | |
| 1921 | W | Howard (DC) | 24 | Shaw (NC) | 0 | ? | |
| 1921 | W | Howard (DC) | 19 | Virginia St. | 0 | Washington, DC | |
| 1921 | W | Howard (DC) | 26 | Virginia-Lynchburg | 0 | ? | |
| 1921 | W | Howard (DC) | 3 | West Virginia St. | 0 | ? | |
| 1921 | W | Howard (DC) | 34 | Hampton (VA) | 0 | Hampton, VA | |
| 1921 | W | Howard Payne (TX) | 56 | Abilene Christian (TX) | 0 | Brownwood, TX | |
| 1921 | W | Howard Payne (TX) | 28 | Hardin-Simmons (TX) | 0 | Abilene, TX | |
| 1921 | L | Howard Payne (TX) | 0 | Texas | 21 | Austin, TX | |
| 1921 | L | Howard Payne (TX) | 7 | Texas A&M | 14 | College Station, TX | |
| 1921 | W | Howard Payne (TX) | 29 | Trinity (TX) | 0 | Brownwood, TX | |
| 1921 | W | Howard Payne (TX) | 21 | Austin (TX) | 14 | Brownwood, TX | |
| 1921 | L | Howard Payne (TX) | 0 | Southern Methodist (TX) | 3 | Dallas, TX | |
| 1921 | W | Howard Payne (TX) | 34 | Southwestern (TX) | 7 | Brownwood, TX | |
| 1921 | L | Howe HS | 0 | Punchard HS (MA) | 34 | ? | |
| 1921 | L | Hudson Falls HS (NY) | 0 | Saratoga Springs HS (NY) | 55 | ? | |
| 1921 | L | Hudson HS (MA) | 0 | Hudson HS Alumni (MA) | 13 | ? | |
| 1921 | L | Hudson HS (MA) | 0 | Leominster HS (MA) | 25 | ? | |
| 1921 | W | Hudson HS (MA) | 7 | Magnard HS | 0 | ? | |
| 1921 | L | Hudson HS (MA) | 7 | Marlboro HS (VT) | 21 | ? | |
| 1921 | L | Hudson HS (MA) | 0 | Milford HS (MA) | 21 | ? | |
| 1921 | L | Hudson HS (MA) | 3 | Natick HS (MA) | 32 | ? | |
| 1921 | T | Hudson HS (MA) | 7 | Needham HS (MA) | 7 | ? | |
| 1921 | L | Hudson HS (MA) | 0 | Saint Marks School (MA) | 30 | ? | |
| 1921 | W | Hudson HS (MA) | 24 | Westboro HS (MA) | 0 | ? | |
| 1921 | W | Hudson HS (MA) | 24 | Whitinsville HS (MA) | 6 | ? | |
| 1921 | L | Hudson HS (MI) | 0 | Tecumseh HS (MI) | 12 | ? | |
| 1921 | L | Hudson HS (WI) | 0 | Stillwater HS (MN) | 27 | ? | |
| 1921 | W | Hudson HS Alumni (MA) | 13 | Hudson HS (MA) | 0 | ? | |
| 1921 | W | Hugoton HS (KS) | 6 | Oklahoma Panhandle St. | 0 | ? | Hugoton HS won - score unknown |
| 1921 | W | Huntingdon HS (PA) | 57 | Altoona Apprentice School (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 34 | Altoona HS (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 35 | Clearfield HS (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 62 | Cumberland HS | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 1 | DuBois HS (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 67 | Gettysburg HS (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 27 | Juniata HS | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 101 | Lewistown HS (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 1 | Lock Haven HS (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 62 | Sunbury HS (PA) | 0 | ? | |
| 1921 | W | Huntingdon HS (PA) | 72 | Yeagertown HS (PA) | 0 | ? | |
| 1921 | L | Huntington HS (MA) | 7 | Worcester Academy (MA) | 42 | ? | |
| 1921 | W | Huntington HS (WV) | 28 | Ashland HS (KY) | 0 | ? | |
| 1921 | W | Huntington HS (WV) | 14 | Athens HS (OH) | 0 | ? | |
| 1921 | W | Huntington HS (WV) | 7 | Charleston HS (WV) | 0 | ? | |
| 1921 | L | Huntington HS (WV) | 13 | Clarksburg HS (WV) | 14 | ? | |
| 1921 | W | Huntington HS (WV) | 21 | Dayton Stivers Manual Training HS (OH) | 13 | ? | |
| 1921 | W | Huntington HS (WV) | 47 | Gallipolis HS (OH) | 0 | ? | |
| 1921 | L | Huntington HS (WV) | 0 | Greenbrier Military Academy (WV) | 6 | ? | |
| 1921 | T | Huntington HS (WV) | 0 | Huntington HS Alumni (WV) | 0 | ? | |
| 1921 | W | Huntington HS (WV) | 20 | Marietta HS (OH) | 0 | ? | |
| 1921 | L | Huntington HS (WV) | 6 | Parkersburg HS (WV) | 27 | ? | |
| 1921 | W | Huntington HS (WV) | 28 | Portsmouth HS (OH) | 0 | ? | |
| 1921 | L | Huntington HS (WV) | 13 | Washington Irving HS (WV) | 14 | ? | |
| 1921 | T | Huntington HS Alumni (WV) | 0 | Huntington HS (WV) | 0 | ? | |
| 1921 | L | Huntington School (MA) | 13 | Cushing Academy (MA) | 20 | ? | |
| 1921 | L | Huron HS (SD) | 0 | Clark HS (SD) | 33 | ? | |
| 1921 | L | Hutchinson Central HS (NY) | 0 | Buffalo Masten Park HS (NY) | 14 | ? | |
| 1921 | L | Hutchinson Central HS (NY) | 0 | Buffalo Technical HS (NY) | 34 | ? | |
| 1921 | L | Hutchinson Central HS (NY) | 6 | Tonawanda HS (NY) | 27 | ? | |
| 1921 | L | Hutchinson KSIR | 0 | McPherson (KS) | 75 | McPherson, KS | |
| 1921 | W | Idaho | 6 | Gonzaga (WA) | 0 | Spokane, WA | |
| 1921 | T | Idaho | 7 | Oregon | 7 | Portland, OR | |
| 1921 | L | Idaho | 7 | Utah | 17 | Salt Lake City, UT | |
| 1921 | L | Idaho | 3 | Washington St. | 20 | Pullman, WA | |
| 1921 | L | Idaho | 3 | Whitman (WA) | 14 | Moscow, ID | |
| 1921 | W | Idaho | 6 | 9th Army Corps (WA) | 0 | Moscow, ID | |
| 1921 | W | Idaho | 35 | Montana | 7 | Moscow, ID | |
| 1921 | W | Idaho | 31 | Wyoming | 3 | Boise, ID | |
| 1921 | L | Idaho Falls HS (ID) | 0 | Brigham Young College (UT) | 34 | ? | |
| 1921 | L | Idaho Falls HS (ID) | 0 | Salt Lake City East Side HS (UT) | 50 | ? | |
| 1921 | W | Idaho Freshmen | 55 | Central Washington | 0 | Ellensburg, WA | |
| 1921 | W | Idaho Freshmen | 34 | Eastern Washington | 0 | Moscow, ID | |
| 1921 | W | Idaho St. | 71 | Blackfoot HS (ID) | 0 | Pocatello, ID | |
| 1921 | W | Idaho St. | 6 | Brigham Young College (UT) | 0 | Logan, UT | |
| 1921 | W | Idaho St. | 13 | College of Idaho | 7 | Pocatello, ID | |
| 1921 | W | Idaho St. | 17 | Gooding (ID) | 10 | Gooding, ID | |
| 1921 | W | Idaho St. | 37 | Ricks JC (ID) | 13 | Pocatello, ID | |
| 1921 | L | Idaho St. | 0 | Utah Freshmen | 3 | Pocatello, ID | |
| 1921 | W | Idaho St. | 34 | Utah St. Freshmen | 0 | Pocatello, ID | |
| 1921 | L | Idaho St. | 0 | Montana | 25 | Missoula, MT | |
| 1921 | T | Ilion HS (NY) | 14 | Herkimer HS (NY) | 14 | ? | |
| 1921 | L | Ilion HS (NY) | 13 | Sherrill HS (NY) | 27 | ? | |
| 1921 | L | Illinois | 2 | Iowa | 14 | Iowa City, IA | |
| 1921 | L | Illinois | 0 | Michigan | 3 | Champaign, IL | |
| 1921 | W | Illinois | 7 | Ohio St. | 0 | Columbus, OH | |
| 1921 | L | Illinois | 0 | Wisconsin | 20 | Champaign, IL | |
| 1921 | W | Illinois | 21 | DePauw (IN) | 0 | Urbana, IL | |
| 1921 | W | Illinois | 52 | South Dakota | 0 | Urbana, IL | |
| 1921 | L | Illinois | 6 | Chicago (IL) | 14 | Champaign, IL | |
| 1921 | W | Illinois College | 87 | Blackburn (IL) | 0 | Jacksonville, IL | |
| 1921 | L | Illinois College | 0 | Bradley (IL) | 20 | Peoria, IL | |
| 1921 | W | Illinois College | 35 | Illinois St. | 0 | Jacksonville, IL | |
| 1921 | L | Illinois College | 6 | Illinois Wesleyan | 17 | Bloomington, IL | |
| 1921 | W | Illinois College | 59 | Shurtleff (IL) | 0 | Jacksonville, IL | |
| 1921 | W | Illinois College | 38 | Monmouth (IL) | 7 | Jacksonville, IL | |
| 1921 | L | Illinois College | 13 | Truman St. (MO) | 16 | Kirksville, MO | |
| 1921 | W | Illinois College | 14 | Eureka (IL) | 0 | Jacksonville, IL | |
| 1921 | L | Illinois St. | 0 | Bradley (IL) | 14 | Normal, IL | |
| 1921 | L | Illinois St. | 0 | Illinois College | 35 | Jacksonville, IL | |
| 1921 | T | Illinois St. | 0 | Illinois Wesleyan | 0 | Bloomington, IL | |
| 1921 | W | Illinois St. | 40 | Lincoln College (IL) | 7 | Normal, IL | |
| 1921 | W | Illinois St. | 42 | Eastern Illinois | 3 | Normal, IL | |
| 1921 | L | Illinois St. | 0 | Eureka (IL) | 8 | Eureka, IL | |
| 1921 | W | Illinois St. | 74 | Blackburn (IL) | 0 | Carlinville, IL | |
| 1921 | L | Illinois Wesleyan | 0 | Augustana (IL) | 14 | Bloomington, IL | |
| 1921 | W | Illinois Wesleyan | 6 | Blackburn (IL) | 0 | Bloomington, IL | |
| 1921 | W | Illinois Wesleyan | 74 | Eastern Illinois | 3 | Bloomington, IL | |
| 1921 | L | Illinois Wesleyan | 0 | Eureka (IL) | 35 | Eureka, IL | |
| 1921 | W | Illinois Wesleyan | 17 | Illinois College | 6 | Bloomington, IL | |
| 1921 | T | Illinois Wesleyan | 0 | Illinois St. | 0 | Bloomington, IL | |
| 1921 | L | Illinois Wesleyan | 7 | Bradley (IL) | 21 | Bloomington, IL | |
| 1921 | W | Illinois Wesleyan | 12 | Knox (IL) | 7 | Bloomington, IL | |
| 1921 | T | Illinois Wesleyan | 7 | Millikin (IL) | 7 | Decatur, IL | |
| 1921 | L | Independence HS (IA) | 0 | Waterloo East HS (IA) | 105 | ? | |
| 1921 | W | Independence HS (KS) | 26 | Caney HS (KS) | 0 | ? | |
| 1921 | W | Independence HS (KS) | 34 | Cherryvale HS (KS) | 0 | ? | |
| 1921 | W | Independence HS (KS) | 35 | Coffeyville HS (KS) | 0 | ? | |
| 1921 | W | Independence HS (KS) | 42 | Fredonia HS (KS) | 3 | ? | |
| 1921 | W | Independence HS (KS) | 13 | Neodesha HS (KS) | 7 | ? | |
| 1921 | T | Independence HS (KS) | 0 | Nowata HS (OK) | 0 | ? | |
| 1921 | W | Independence HS (KS) | 48 | Oltamont HS | 0 | ? | |
| 1921 | W | Independence HS (KS) | 41 | Oswego HS (KS) | 0 | ? | |
| 1921 | W | Indiana | 47 | Franklin (IN) | 0 | Bloomington, IN | |
| 1921 | L | Indiana | 0 | Minnesota | 6 | Minneapolis, MN | |
| 1921 | L | Indiana | 7 | Notre Dame (IN) | 28 | Indianapolis, IN | |
| 1921 | W | Indiana | 3 | Purdue (IN) | 0 | Bloomington, IN | |
| 1921 | W | Indiana | 29 | Kalamazoo (MI) | 0 | Bloomington, IN | |
| 1921 | L | Indiana | 0 | Harvard (MA) | 19 | Cambridge, MA | |
| 1921 | L | Indiana | 0 | Iowa | 41 | Iowa City, IA | |
| 1921 | W | Indiana (PA) | 7 | Blacklick | 0 | Indiana, PA | |
| 1921 | L | Indiana (PA) | 0 | California (PA) | 14 | ? | |
| 1921 | W | Indiana (PA) | 47 | Curwensville HS (PA) | 0 | ? | |
| 1921 | L | Indiana (PA) | 0 | DuBois HS (PA) | 3 | ? | |
| 1921 | W | Indiana (PA) | 19 | Saint Francis (PA) | 0 | ? | |
| 1921 | L | Indiana (PA) | 0 | Slippery Rock (PA) | 42 | Indiana, PA | |
| 1921 | W | Indiana (PA) | 15 | Pittsburgh Academy (PA) | 7 | Indiana, PA | |
| 1921 | W | Indiana (PA) | 7 | Clarion (PA) | 0 | Clarion, PA | Pinks Field |
| 1921 | L | Indiana St. | 0 | Rose-Hulman Tech (IN) | 19 | ? | |
| 1921 | L | Indianapolis Arsenal Technical School (IN) | 14 | Dayton Steele HS (OH) | 49 | ? | |
| 1921 | T | Indianapolis Arsenal Technical School (IN) | 0 | Indianapolis Shortridge HS (IN) | 0 | ? | |
| 1921 | T | Indianapolis HS (IN) | 7 | Louisville HS (KY) | 7 | ? | |
| 1921 | W | Indianapolis Manual Training HS (IN) | 50 | Indianapolis Shortridge HS (IN) | 0 | ? | |
| 1921 | W | Indianapolis Shortridge HS (IN) | 6 | Bloomfield HS (IN) | 0 | ? | |
| 1921 | L | Indianapolis Shortridge HS (IN) | 0 | Brazil HS (IN) | 6 | ? | |
| 1921 | W | Indianapolis Shortridge HS (IN) | 7 | Elwood HS (IN) | 0 | ? | |
| 1921 | T | Indianapolis Shortridge HS (IN) | 0 | Indianapolis Arsenal Technical School (IN) | 0 | ? | |
| 1921 | L | Indianapolis Shortridge HS (IN) | 0 | Indianapolis Manual Training HS (IN) | 50 | ? | |
| 1921 | W | Indianapolis Shortridge HS (IN) | 32 | Wabash HS (IN) | 7 | ? | |
| 1921 | L | Indianola HS (MS) | 0 | Greenville HS (MS) | 92 | ? | |
| 1921 | W | Iowa | 14 | Illinois | 2 | Iowa City, IA | |
| 1921 | W | Iowa | 14 | Northwestern (IL) | 0 | Evanston, IL | |
| 1921 | W | Iowa | 13 | Purdue (IN) | 6 | West Lafayette, IN | |
| 1921 | W | Iowa | 52 | Knox (IL) | 14 | Iowa City, IA | |
| 1921 | W | Iowa | 41 | Minnesota | 7 | Minneapolis, MN | |
| 1921 | W | Iowa | 10 | Notre Dame (IN) | 7 | Iowa City, IA | |
| 1921 | W | Iowa | 41 | Indiana | 0 | Iowa City, IA | |
| 1921 | L | Iowa Falls HS (IA) | 7 | Waterloo East HS (IA) | 13 | ? | |
| 1921 | L | Iowa St. | 7 | Kansas | 14 | Ames, IA | |
| 1921 | L | Iowa St. | 14 | Missouri | 17 | Columbia, MO | |
| 1921 | L | Iowa St. | 3 | Nebraska | 35 | Ames, IA | |
| 1921 | L | Iowa St. | 0 | Washington (MO) | 2 | Saint Louis, MO | |
| 1921 | W | Iowa St. | 28 | Coe (IA) | 3 | Ames, IA | |
| 1921 | W | Iowa St. | 7 | Drake (IA) | 0 | Des Moines, IA | |
| 1921 | W | Iowa St. | 21 | Grinnell (IA) | 3 | Ames, IA | |
| 1921 | W | Iowa St. | 7 | Kansas St. | 0 | Ames, IA | |
| 1921 | L | Iowa State Teachers College HS | 0 | Osage HS (IA) | 28 | ? | |
| 1921 | W | Iowa Wesleyan | 26 | Carthage (WI) | 0 | Mount Pleasant, IA | |
| 1921 | L | Iowa Wesleyan | 7 | Cornell College (IA) | 27 | Mount Pleasant, IA | |
| 1921 | W | Iowa Wesleyan | 7 | Parsons (IA) | 0 | Fairfield, IA | |
| 1921 | W | Iowa Wesleyan | 28 | Central (IA) | 0 | Mount Pleasant, IA | |
| 1921 | L | Iowa Wesleyan | 3 | Monmouth (IL) | 7 | Mount Pleasant, IA | |
| 1921 | T | Iowa Wesleyan | 7 | Simpson (IA) | 7 | Mount Pleasant, IA | |
| 1921 | L | Ironton HS (OH) | 13 | Chillicothe HS (OH) | 14 | ? | |
| 1921 | W | Ironton Tanks | 19 | Charleston (WV) | 14 | ? | |
| 1921 | L | Ironwood HS (MI) | 13 | Calumet HS (MI) | 19 | ? | |
| 1921 | W | Irving School (NY) | 35 | Concordia Prep School (NY) | 0 | ? | |
| 1921 | W | Irving School (NY) | 38 | Jersey City Kingsley HS (NJ) | 0 | ? | |
| 1921 | W | Irving School (NY) | 19 | Pleasantville HS (NY) | 0 | ? | |
| 1921 | T | Irving School (NY) | 7 | Port Chester HS (NY) | 7 | ? | |
| 1921 | W | Irving School (NY) | 21 | White Plains HS (NY) | 7 | ? | |
| 1921 | L | Irvington HS (NJ) | 7 | Battin HS (NJ) | 21 | ? | |
| 1921 | L | Irvington HS (NJ) | 0 | Bloomfield HS (NJ) | 39 | ? | |
| 1921 | L | Irvington HS (NJ) | 6 | Clifton HS (NJ) | 13 | ? | |
| 1921 | L | Irvington HS (NJ) | 13 | Newark South Side HS (NJ) | 20 | ? | |
| 1921 | L | Irvington HS (NJ) | 0 | Nutley HS (NJ) | 17 | ? | |
| 1921 | L | Irvington HS (NJ) | 0 | Orange HS (NJ) | 28 | ? | |
| 1921 | L | Irvington HS (NJ) | 0 | Plainfield HS (NJ) | 42 | ? | |
| 1921 | T | Irvington HS (NJ) | 13 | Somerville HS (NJ) | 13 | ? | |
| 1921 | L | Irvington HS (NJ) | 6 | Union Hill HS (NJ) | 7 | ? | |
| 1921 | W | Irvington HS (NJ) | 21 | West Orange HS (NJ) | 0 | ? | |
| 1921 | W | Ithaca HS (NY) | 14 | Binghamton Central HS (NY) | 0 | ? | |
| 1921 | T | Ithaca HS (NY) | 0 | Syracuse North HS (NY) | 0 | ? | |
| 1921 | W | Jackson Agricultural School (AL) | 54 | Bay Minette HS (AL) | 0 | ? | |
| 1921 | W | Jackson Agricultural School (AL) | 102 | Camden HS (AL) | 0 | ? | |
| 1921 | L | Jackson Agricultural School (AL) | 0 | Clarke County HS (AL) | 26 | ? | |
| 1921 | W | Jackson Agricultural School (AL) | 26 | Repton HS (AL) | 0 | ? | |
| 1921 | W | Jackson Agricultural School (AL) | 21 | Spring Hill AC | 0 | ? | |
| 1921 | T | Jackson Agricultural School (AL) | 0 | Spring Hill HS (AL) | 0 | ? | |
| 1921 | W | Jackson Agricultural School (AL) | 26 | Thomaston HS (AL) | 0 | ? | |
| 1921 | L | Jackson Agricultural School (AL) | 0 | Thomasville HS (AL) | 13 | ? | |
| 1921 | L | Jackson HS (MI) | 14 | Albion HS (MI) | 23 | ? | |
| 1921 | T | Jackson HS (MI) | 7 | Ann Arbor HS (MI) | 7 | ? | |
| 1921 | L | Jackson HS (MI) | 0 | Lansing HS (MI) | 14 | ? | |
| 1921 | L | Jackson HS (MO) | 0 | Marvin College (MO) | 1 | ? | Jackson HS Forfeits |
| 1921 | W | Jackson HS (MO) | 13 | Marvin College (MO) | 0 | ? | |
| 1921 | W | Jackson HS (MS) | 21 | Brookhaven HS (MS) | 2 | ? | |
| 1921 | W | Jackson HS (MS) | 14 | Canton HS (MS) | 0 | ? | |
| 1921 | W | Jackson HS (MS) | 19 | Clinton HS (MS) | 0 | ? | |
| 1921 | T | Jackson HS (MS) | 0 | McComb County HS (MS) | 0 | ? | |
| 1921 | L | Jackson HS (MS) | 7 | Shreveport HS (LA) | 28 | ? | |
| 1921 | W | Jackson HS (MS) | 47 | Yazoo City HS (MS) | 0 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 21 | Charleston HS (SC) | 3 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 21 | Dayton Steele HS (OH) | 0 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 56 | Gainesville HS (FL) | 0 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 77 | Lake City HS (FL) | 0 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 34 | Montgomery HS (AL) | 0 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 44 | Moultrie HS (GA) | 0 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 39 | Saint Petersburg HS (FL) | 0 | ? | |
| 1921 | W | Jacksonville Duval HS (FL) | 74 | Tampa HS (FL) | 0 | ? | |
| 1921 | L | Jacksonville HS (IL) | 7 | Alton HS (IL) | 21 | ? | |
| 1921 | L | Jacksonville HS (IL) | 0 | Hannibal HS (MO) | 14 | ? | |
| 1921 | W | Jacksonville HS (IL) | 21 | Lincoln HS (IL) | 0 | ? | |
| 1921 | L | Jacksonville HS (IL) | 14 | Peoria Manual HS (IL) | 21 | ? | |
| 1921 | L | Jacksonville HS (IL) | 7 | Pittsfield HS (IL) | 14 | ? | |
| 1921 | W | Jacksonville HS (IL) | 13 | Quincy HS (IL) | 6 | ? | |
| 1921 | W | Jacksonville HS (IL) | 7 | Springfield HS (IL) | 0 | ? | |
| 1921 | W | Jacksonville HS (IL) | 49 | Waverly HS (IL) | 0 | ? | |
| 1921 | L | Jacksonville HS (IL) | 0 | Western Military Academy (IL) | 7 | ? | |
| 1921 | W | Jacksonville HS (IL) | 28 | White Hall HS (IL) | 7 | ? | |
| 1921 | T | Jacksonville St. (AL) | 0 | Anniston Independents (AL) | 0 | ? | |
| 1921 | W | Jacksonville St. (AL) | 55 | Gadsden Independents (AL) | 0 | ? | |
| 1921 | W | Jacksonville St. (AL) | 48 | Lineville HS (AL) | 0 | ? | |
| 1921 | T | Jacksonville St. (AL) | 0 | Marion Military Institute (AL) | 0 | ? | |
| 1921 | W | Jacksonville St. (AL) | 55 | Oneonta HS (AL) | 0 | ? | |
| 1921 | W | Jacksonville St. (AL) | 42 | Oneonta HS (AL) | 0 | ? | |
| 1921 | L | Jacksonville St. (AL) | 7 | Samford (AL) | 39 | Birmingham, AL | |
| 1921 | W | Jacksonville St. (AL) | 68 | Sylacauga Agriculture School (AL) | 0 | ? | |
| 1921 | L | Jacksonville St. (AL) | 0 | Florida Military College | 68 | Jacksonville, AL | |
| 1921 | L | Jamaica HS (NY) | 0 | Flushing HS (NY) | 13 | ? | |
| 1921 | T | Jamaica HS (NY) | 0 | Hempstead HS (NY) | 0 | ? | |
| 1921 | W | Jamaica HS (NY) | 26 | Hollis FC | 6 | ? | |
| 1921 | T | Jamaica HS (NY) | 7 | Lynbrook HS (NY) | 7 | ? | |
| 1921 | L | Jamaica HS (NY) | 0 | Montclair HS (NJ) | 55 | ? | |
| 1921 | L | Jamaica HS (NY) | 0 | Saint Francis Prep (NY) | 13 | ? | |
| 1921 | T | James John HS (OR) | 0 | Castle Rock HS (WA) | 0 | ? | |
| 1921 | L | James John HS (OR) | 0 | Franklin HS | 10 | ? | |
| 1921 | L | James John HS (OR) | 0 | Jefferson HS (OR) | 28 | ? | |
| 1921 | L | James John HS (OR) | 0 | Lincoln HS | 25 | ? | |
| 1921 | L | James John HS (OR) | 7 | Portland Benson Polytechnic School (OR) | 58 | ? | |
| 1921 | L | James John HS (OR) | 6 | Portland HS of Commerce (OR) | 7 | ? | |
| 1921 | L | James John HS (OR) | 0 | Portland Washington HS (OR) | 56 | ? | |
| 1921 | T | James John HS (OR) | 6 | Ridgefield HS (WA) | 6 | ? | |
| 1921 | L | James John HS (OR) | 7 | Vancouver HS (WA) | 28 | ? | |
| 1921 | L | Jamestown (ND) | 0 | Concordia-Moorhead (MN) | 28 | Moorhead, MN | |
| 1921 | L | Jamestown (ND) | 0 | Fargo College (ND) | 13 | Fargo, ND | |
| 1921 | W | Jamestown (ND) | 28 | Valley City St. (ND) | 7 | ? | |
| 1921 | T | Jamestown (ND) | 0 | North Dakota St. | 0 | Jamestown, ND | |
| 1921 | L | Jamestown (ND) | 0 | North Dakota | 64 | Grand Forks, ND | |
| 1921 | W | Jamestown HS (NY) | 13 | Kane HS (PA) | 0 | ? | |
| 1921 | L | Jarvis Christian (TX) | 0 | Texas College | 6 | ? | |
| 1921 | L | Jarvis Christian (TX) | 0 | Wiley (TX) | 40 | ? | |
| 1921 | L | Jasper Marion County HS (TN) | 6 | Baylor Military Academy (TN) | 45 | ? | |
| 1921 | L | Jefferson (LA) | 7 | Loyola (LA) | 27 | New Orleans, LA | |
| 1921 | L | Jefferson (LA) | 6 | Spring Hill (AL) | 84 | Mobile, AL | |
| 1921 | L | Jefferson (LA) | 0 | Louisiana-Lafayette | 35 | Lafayette, LA | |
| 1921 | W | Jefferson HS (OR) | 28 | James John HS (OR) | 0 | ? | |
| 1921 | L | Jeffersonville HS (IN) | 0 | Elizabethtown HS (KY) | 45 | ? | |
| 1921 | W | Jersey City Dickinson HS (NJ) | 28 | Bayonne HS (NJ) | 0 | ? | |
| 1921 | L | Jersey City Dickinson HS (NJ) | 0 | Dewitt Clinton HS (NY) | 6 | ? | |
| 1921 | T | Jersey City Dickinson HS (NJ) | 0 | Dover HS (NJ) | 0 | ? | |
| 1921 | L | Jersey City Dickinson HS (NJ) | 0 | East Orange HS (NJ) | 28 | ? | |
| 1921 | W | Jersey City Dickinson HS (NJ) | 40 | Jersey City Lincoln HS (NJ) | 0 | ? | |
| 1921 | L | Jersey City Dickinson HS (NJ) | 2 | Montclair HS (NJ) | 28 | ? | |
| 1921 | L | Jersey City Dickinson HS (NJ) | 6 | Newark Barringer HS (NJ) | 7 | ? | |
| 1921 | W | Jersey City Dickinson HS (NJ) | 28 | Red Bank HS (NJ) | 0 | ? | |
| 1921 | L | Jersey City Dickinson HS (NJ) | 7 | Saint Peter's Prep (NJ) | 13 | ? | |
| 1921 | L | Jersey City Kingsley HS (NJ) | 6 | Carlton Academy (NJ) | 19 | ? | |
| 1921 | L | Jersey City Kingsley HS (NJ) | 0 | Hackley School (NY) | 35 | ? | |
| 1921 | L | Jersey City Kingsley HS (NJ) | 6 | Hoboken Stevens Prep HS (NJ) | 18 | ? | |
| 1921 | L | Jersey City Kingsley HS (NJ) | 0 | Irving School (NY) | 38 | ? | |
| 1921 | W | Jersey City Lincoln HS (NJ) | 1 | Bloomfield HS (NJ) | 0 | ? | |
| 1921 | L | Jersey City Lincoln HS (NJ) | 0 | Jersey City Dickinson HS (NJ) | 40 | ? | |
| 1921 | L | Jersey City Lincoln HS (NJ) | 0 | Montclair Military Academy (NJ) | 42 | ? | |
| 1921 | L | Jersey City Lincoln HS (NJ) | 0 | Newark Academy (NJ) | 13 | ? | |
| 1921 | L | Jersey City Lincoln HS (NJ) | 0 | Nutley HS (NJ) | 48 | ? | |
| 1921 | L | Jersey City Lincoln HS (NJ) | 0 | Orange HS (NJ) | 14 | ? | |
| 1921 | L | Jersey City Lincoln HS (NJ) | 0 | Saint Peter's Prep (NJ) | 12 | ? | |
| 1921 | W | Jersey City Lincoln HS (NJ) | 6 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | W | Jersey City Lincoln HS (NJ) | 36 | Union Hill HS (NJ) | 0 | ? | |
| 1921 | L | Jersey Shore HS (PA) | 12 | Williamsport HS (PA) | 25 | ? | |
| 1921 | L | John C. Fremont HS (CA) | 6 | San Francisco Lick Wilmerling HS (CA) | 13 | ? | |
| 1921 | W | John Carroll (OH) | 19 | Baldwin-Wallace (OH) | 13 | Berea, OH | |
| 1921 | L | John Carroll (OH) | 6 | Dayton (OH) | 13 | Dayton, OH | |
| 1921 | L | John Carroll (OH) | 0 | Hiram (OH) | 14 | Cleveland, OH | |
| 1921 | L | John Carroll (OH) | 7 | Niagara (NY) | 13 | Cleveland, OH | |
| 1921 | L | John Carroll (OH) | 21 | Westminster (PA) | 28 | New Wilmington, PA | |
| 1921 | L | John Carroll (OH) | 0 | Xavier (OH) | 28 | Cincinnati, OH | |
| 1921 | W | John Carroll (OH) | 13 | Kent St. (OH) | 0 | Kent, OH | |
| 1921 | L | John Carroll (OH) | 6 | Canisius (NY) | 24 | Cleveland, OH | |
| 1921 | L | John Marshall HS (VA) | 0 | Fork Union Military Academy (VA) | 35 | ? | |
| 1921 | L | John Tarleton College (TX) | 0 | Baylor (TX) | 35 | Waco, TX | |
| 1921 | W | John Tarleton College (TX) | 20 | Baylor Freshmen (TX) | 6 | ? | |
| 1921 | W | John Tarleton College (TX) | 34 | Clarendon College (TX) | 3 | ? | |
| 1921 | W | John Tarleton College (TX) | 47 | Clifton JC (TX) | 0 | ? | |
| 1921 | W | John Tarleton College (TX) | 38 | Decatur Baptist College (TX) | 0 | ? | |
| 1921 | W | John Tarleton College (TX) | 21 | Meridian College (TX) | 0 | ? | |
| 1921 | W | John Tarleton College (TX) | 13 | North Texas | 0 | ? | |
| 1921 | T | John Tarleton College (TX) | 7 | Texas-Arlington | 7 | ? | |
| 1921 | W | John Tarleton College (TX) | 49 | Weatherford (TX) | 6 | ? | |
| 1921 | W | John Tarleton College (TX) | 13 | Daniel Baker (TX) | 7 | Brownwood, TX | |
| 1921 | W | Johns Hopkins (MD) | 6 | Dickinson (PA) | 0 | Baltimore, MD | |
| 1921 | W | Johns Hopkins (MD) | 44 | McDaniel College (MD) | 0 | Baltimore, MD | |
| 1921 | W | Johns Hopkins (MD) | 17 | Saint John's (MD) | 3 | Baltimore, MD | |
| 1921 | L | Johns Hopkins (MD) | 7 | Virginia | 14 | Charlottesville, VA | |
| 1921 | L | Johns Hopkins (MD) | 0 | Washington & Lee (VA) | 7 | Baltimore, MD | |
| 1921 | W | Johns Hopkins (MD) | 3 | Mount Saint Mary's (MD) | 2 | Baltimore, MD | |
| 1921 | W | Johns Hopkins (MD) | 28 | Haverford (PA) | 3 | Baltimore, MD | |
| 1921 | W | Johns Hopkins (MD) | 27 | Delaware | 0 | Baltimore, MD | |
| 1921 | L | Johns Hopkins (MD) | 0 | Swarthmore (PA) | 7 | Swarthmore, PA | |
| 1921 | L | Johns Hopkins Freshmen (MD) | 0 | Severn School (MD) | 27 | ? | |
| 1921 | L | Johnson C. Smith (NC) | 6 | Livingstone (NC) | 25 | ? | |
| 1921 | L | Johnson C. Smith (NC) | 0 | Morehouse (GA) | 41 | ? | |
| 1921 | T | Johnson C. Smith (NC) | 0 | Virginia St. | 0 | ? | |
| 1921 | L | Johnson City All-Stars (TN) | 7 | East Tennessee St. | 14 | ? | |
| 1921 | L | Johnson City All-Stars (TN) | 0 | Milligan (TN) | 21 | ? | |
| 1921 | L | Johnson City HS | 0 | Murphysboro HS (IL) | 39 | ? | |
| 1921 | L | Johnson HS | 0 | Essex County Agriculture School (MA) | 51 | ? | |
| 1921 | T | Johnson HS | 7 | Punchard HS (MA) | 7 | ? | |
| 1921 | W | Johnstown HS (PA) | 85 | Altoona HS (PA) | 0 | ? | |
| 1921 | W | Johnstown HS (PA) | 35 | Apollo HS (PA) | 0 | ? | |
| 1921 | W | Johnstown HS (PA) | 70 | Avalon HS (PA) | 0 | ? | |
| 1921 | W | Johnstown HS (PA) | 42 | Connellsville HS (PA) | 0 | ? | |
| 1921 | L | Johnstown HS (PA) | 13 | Greensburg HS (PA) | 14 | ? | |
| 1921 | W | Johnstown HS (PA) | 67 | Mount Union HS (PA) | 0 | ? | |
| 1921 | W | Johnstown HS (PA) | 41 | Norwin HS | 0 | ? | |
| 1921 | W | Johnstown HS (PA) | 28 | Pittsburg Academy | 0 | ? | |
| 1921 | W | Johnstown HS (PA) | 73 | Pittsburgh 5th Ave. HS (PA) | 0 | ? | |
| 1921 | L | Johnstown HS (PA) | 0 | Toledo Scott HS (OH) | 34 | ? | |
| 1921 | W | Johnstown HS (PA) | 27 | Windber HS (PA) | 0 | ? | |
| 1921 | L | Joliet HS (IL) | 0 | Elgin HS (IL) | 52 | ? | |
| 1921 | L | Joliet HS (IL) | 0 | Freeport HS (IL) | 62 | ? | |
| 1921 | L | Jonesboro HS (AR) | 0 | Memphis Central HS (TN) | 21 | ? | |
| 1921 | L | Jonesboro HS (AR) | 0 | Memphis Central HS (TN) | 21 | ? | |
| 1921 | W | Joplin HS (MO) | 41 | Baxter Springs HS (KS) | 0 | ? | |
| 1921 | W | Joplin HS (MO) | 20 | Carl Junction HS (MO) | 0 | ? | |
| 1921 | L | Joplin HS (MO) | 0 | Carthage HS (MO) | 19 | ? | |
| 1921 | W | Joplin HS (MO) | 20 | Columbus HS (KS) | 3 | ? | |
| 1921 | W | Joplin HS (MO) | 17 | Fort Smith HS (AR) | 7 | ? | |
| 1921 | L | Joplin HS (MO) | 0 | Monett HS (MO) | 12 | ? | |
| 1921 | W | Joplin HS (MO) | 38 | Mount Vernon HS (MO) | 0 | ? | |
| 1921 | L | Joplin HS (MO) | 6 | Muskogee HS (OK) | 21 | ? | |
| 1921 | L | Joplin HS (MO) | 0 | Neosho HS (MO) | 20 | ? | |
| 1921 | T | Joplin HS (MO) | 7 | Springfield HS (MO) | 7 | ? | |
| 1921 | W | Joplin HS (MO) | 48 | Webb City HS (MO) | 0 | ? | |
| 1921 | W | Joplin HS (MO) | 41 | Wheaton HS (MO) | 0 | ? | |
| 1921 | L | Jordan HS | 7 | Salt Lake City East Side HS (UT) | 58 | ? | |
| 1921 | W | Jordan HS | 41 | Westminster College (UT) | 0 | ? | |
| 1921 | L | Jordan HS (MN) | 6 | New Prague HS (MN) | 7 | ? | |
| 1921 | L | Jordan HS JV | 0 | Westminster College (UT) | 19 | ? | |
| 1921 | L | Juniata (PA) | 0 | Albright (PA) | 41 | Westminster, MD | |
| 1921 | L | Juniata (PA) | 0 | Bellefonte Academy (PA) | 64 | Huntingdon, PA | Juniata HS? |
| 1921 | L | Juniata (PA) | 0 | Drexel Institute (PA) | 13 | Philadelphia, PA | |
| 1921 | L | Juniata (PA) | 0 | Thiel (PA) | 6 | Huntingdon, PA | |
| 1921 | L | Juniata (PA) | 0 | Dickinson (PA) | 45 | Carlisle, PA | |
| 1921 | L | Juniata (PA) | 0 | Lebanon Valley (PA) | 34 | Huntingdon, PA | |
| 1921 | L | Juniata (PA) | 0 | Geneva (PA) | 54 | Huntingdon, PA | |
| 1921 | L | Juniata (PA) | 0 | Saint Bonaventure (NY) | 12 | Saint Bonaventure, NY | YMCA Field |
| 1921 | W | Juniata HS | 57 | Browning HS | 0 | ? | |
| 1921 | W | Juniata HS | 7 | Brunswick | 0 | ? | |
| 1921 | W | Juniata HS | 7 | Greenwich HS (CT) | 0 | ? | |
| 1921 | L | Juniata HS | 0 | Hackley School (NY) | 48 | ? | |
| 1921 | L | Juniata HS | 0 | Huntingdon HS (PA) | 27 | ? | |
| 1921 | W | Juniata HS | 38 | Sanford HS (ME) | 0 | ? | |
| 1921 | L | Juniata HS | 0 | Stamford HS JV (CT) | 21 | ? | |
| 1921 | T | Juniata JV (PA) | 7 | Altoona HS (PA) | 7 | ? | |
| 1921 | T | K. of C. | 0 | Regis (CO) | 0 | ? | |
| 1921 | W | Kalamazoo (MI) | 15 | Alma (MI) | 0 | Alma, MI | |
| 1921 | W | Kalamazoo (MI) | 48 | Franklin (IN) | 7 | Kalamazoo, MI | |
| 1921 | W | Kalamazoo (MI) | 21 | North Central (IL) | 6 | Kalamazoo, MI | |
| 1921 | L | Kalamazoo (MI) | 0 | Notre Dame (IN) | 56 | South Bend, IN | |
| 1921 | W | Kalamazoo (MI) | 34 | Olivet (MI) | 0 | Olivet, MI | |
| 1921 | L | Kalamazoo (MI) | 0 | Indiana | 29 | Bloomington, IN | |
| 1921 | W | Kalamazoo (MI) | 7 | Albion (MI) | 0 | Kalamazoo, MI | |
| 1921 | W | Kalamazoo (MI) | 97 | Ferris St. (MI) | 6 | Kalamazoo, MI | |
| 1921 | W | Kalamazoo (MI) | 12 | Valparaiso (IN) | 0 | Valparaiso, IN | |
| 1921 | W | Kalamazoo HS (MI) | 13 | Ann Arbor HS (MI) | 7 | ? | |
| 1921 | W | Kalamazoo HS (MI) | 27 | Grand Rapids Union HS (MI) | 0 | ? | |
| 1921 | W | Kalamazoo HS (MI) | 13 | Marshall HS (MI) | 3 | ? | |
| 1921 | L | Kalamazoo HS (MI) | 0 | Muskegon HS (MI) | 20 | ? | |
| 1921 | L | Kane HS (PA) | 0 | Jamestown HS (NY) | 13 | ? | |
| 1921 | W | Kane HS (PA) | 39 | Ludlow HS (PA) | 0 | ? | |
| 1921 | W | Kane HS (PA) | 6 | Olean HS (NY) | 0 | ? | |
| 1921 | L | Kane HS (PA) | 7 | Ridgway HS (PA) | 12 | ? | |
| 1921 | W | Kane HS (PA) | 12 | Ridgway HS (PA) | 10 | ? | |
| 1921 | L | Kane HS (PA) | 7 | Warren HS (PA) | 33 | ? | |
| 1921 | W | Kane HS (PA) | 21 | Warren HS (PA) | 0 | ? | |
| 1921 | W | Kankakee HS (IL) | 16 | Danville HS (IL) | 9 | ? | |
| 1921 | L | Kankakee HS (IL) | 0 | Proviso Township HS (IL) | 20 | ? | |
| 1921 | L | Kansas | 7 | Drake (IA) | 15 | Lawrence, KS | |
| 1921 | W | Kansas | 14 | Iowa St. | 7 | Ames, IA | |
| 1921 | W | Kansas | 21 | Kansas St. | 7 | Lawrence, KS | |
| 1921 | W | Kansas | 15 | Missouri | 9 | Lawrence, KS | |
| 1921 | W | Kansas | 28 | Washburn (KS) | 7 | Topeka, KS | |
| 1921 | L | Kansas | 7 | Oklahoma | 24 | Norman, OK | |
| 1921 | L | Kansas | 0 | Nebraska | 28 | Lincoln, NE | |
| 1921 | W | Kansas City (KS) | 6 | Central Missouri St. | 0 | Warrensburg, MO | |
| 1921 | W | Kansas City (KS) | 21 | Wentworth Military Academy (MO) | 0 | ? | |
| 1921 | L | Kansas City (KS) | 0 | Saint Louis (MO) | 12 | Saint Louis, MO | |
| 1921 | L | Kansas City Manual HS (MO) | 0 | Sapulpa HS (OK) | 54 | ? | |
| 1921 | W | Kansas Industrial and Educational Institute | 7 | Lincoln (MO) | 0 | ? | |
| 1921 | L | Kansas School for the Deaf and Dumb | 6 | Benedictine (KS) | 41 | Atchison, KS | |
| 1921 | L | Kansas St. | 7 | Creighton (NE) | 14 | Omaha, NE | |
| 1921 | L | Kansas St. | 7 | Kansas | 21 | Lawrence, KS | |
| 1921 | W | Kansas St. | 7 | Missouri | 5 | Manhattan, KS | |
| 1921 | W | Kansas St. | 14 | Oklahoma | 7 | Manhattan, KS | |
| 1921 | W | Kansas St. | 7 | College of Emporia (KS) | 3 | Manhattan, KS | |
| 1921 | W | Kansas St. | 21 | Grinnell (IA) | 7 | Manhattan, KS | |
| 1921 | W | Kansas St. | 21 | Washington (MO) | 0 | Manhattan, KS | |
| 1921 | L | Kansas St. | 0 | Iowa St. | 7 | Ames, IA | |
| 1921 | L | Kansas Wesleyan | 0 | Baker (KS) | 13 | Baldwin City, KS | |
| 1921 | L | Kansas Wesleyan | 6 | Bethany (KS) | 16 | Salina, KS | |
| 1921 | L | Kansas Wesleyan | 0 | Fort Hays St. (KS) | 18 | Salina, KS | |
| 1921 | L | Kansas Wesleyan | 0 | Haskell Indian Nations (KS) | 89 | Lawrence, KS | |
| 1921 | L | Kansas Wesleyan | 0 | McPherson (KS) | 19 | McPherson, KS | |
| 1921 | L | Kansas Wesleyan | 0 | Wichita St. (KS) | 24 | Wichita, KS | Kansas Wesleyan left field during game |
| 1921 | L | Kansas Wesleyan | 0 | Friends (KS) | 36 | Salina, KS | |
| 1921 | L | Kansas Wesleyan | 0 | Sterling (KS) | 6 | Salina, KS | |
| 1921 | L | Kasson HS (MN) | 3 | Owatonna HS (MN) | 12 | ? | |
| 1921 | L | Kasson HS (MN) | 0 | Rochester HS (MN) | 20 | ? | |
| 1921 | W | Kasson HS (MN) | 40 | Stewartville HS (MN) | 0 | ? | |
| 1921 | L | Kearney Military Academy (NE) | 0 | Cambridge HS (NE) | 57 | ? | |
| 1921 | L | Keene HS (NH) | 7 | Manchester HS (NH) | 57 | ? | |
| 1921 | W | Kemper Military School (MO) | 49 | Central Missouri St. | 0 | Boonville, MO | |
| 1921 | W | Kemper Military School (MO) | 7 | Culver Military Academy (IN) | 3 | ? | |
| 1921 | L | Kemper Military School (MO) | 6 | Missouri Military Academy | 7 | ? | |
| 1921 | L | Kemper Military School (MO) | 0 | Saint John's Military Academy (WI) | 56 | ? | |
| 1921 | W | Kemper Military School (MO) | 89 | Sedalia HS (MO) | 0 | ? | |
| 1921 | W | Kemper Military School (MO) | 13 | Wentworth Military Academy (MO) | 0 | ? | |
| 1921 | L | Kemper Military School (MO) | 6 | Central Methodist (MO) | 14 | Fayette, MO | |
| 1921 | W | Kemper Military School (MO) | 7 | Chillicothe Business College (MO) | 6 | Boonville, MO | |
| 1921 | L | Kenmore HS | 6 | Canton McKinley HS (OH) | 14 | ? | |
| 1921 | L | Kennewick HS (WA) | 3 | Pendleton HS (OR) | 7 | ? | |
| 1921 | L | Kenosha HS (WI) | 7 | Beloit HS (WI) | 9 | ? | |
| 1921 | W | Kenosha HS (WI) | 21 | Fort Atkinson HS (WI) | 0 | ? | |
| 1921 | W | Kenosha HS (WI) | 14 | Madison HS (WI) | 13 | ? | |
| 1921 | L | Kenosha HS (WI) | 7 | Milwaukee South Division HS (WI) | 28 | ? | |
| 1921 | L | Kenosha HS (WI) | 0 | Milwaukee Washington HS (WI) | 69 | ? | |
| 1921 | L | Kenosha HS (WI) | 0 | Sheboygan HS (WI) | 32 | ? | |
| 1921 | W | Kenosha HS (WI) | 6 | Waukesha HS (WI) | 0 | ? | |
| 1921 | T | Kenosha HS (WI) | 6 | West Allis HS (WI) | 6 | ? | |
| 1921 | L | Kent School (CT) | 9 | Hotchkiss Academy (CT) | 13 | ? | |
| 1921 | W | Kent School (CT) | 13 | Pawling School (NY) | 7 | ? | |
| 1921 | L | Kent St. (OH) | 0 | Ashland (OH) | 7 | Kent, OH | |
| 1921 | T | Kent St. (OH) | 0 | Bowling Green (OH) | 0 | Bowling Green, OH | |
| 1921 | L | Kent St. (OH) | 0 | John Carroll (OH) | 13 | Kent, OH | |
| 1921 | L | Kenton HS (OH) | 0 | Mount Cory HS (OH) | 9 | ? | |
| 1921 | W | Kentucky | 33 | Georgetown (KY) | 0 | Lexington, KY | |
| 1921 | L | Kentucky | 0 | Sewanee (TN) | 6 | Louisville, KY | |
| 1921 | T | Kentucky | 0 | Tennessee | 0 | Lexington, KY | |
| 1921 | L | Kentucky | 14 | Vanderbilt (TN) | 21 | Lexington, KY | |
| 1921 | W | Kentucky | 68 | Kentucky Wesleyan | 0 | Lexington, KY | |
| 1921 | L | Kentucky | 0 | Centre (KY) | 55 | Danville, KY | |
| 1921 | W | Kentucky | 28 | Marshall (WV) | 0 | Lexington, KY | |
| 1921 | W | Kentucky | 14 | Virginia Military Institute | 7 | Louisville, KY | |
| 1921 | W | Kentucky JV | 20 | Eastern Kentucky | 0 | Richmond, KY | |
| 1921 | W | Kentucky St. | 33 | Bowling Green Academy (KY) | 0 | ? | |
| 1921 | W | Kentucky St. | 39 | Fort Knox (KY) | 0 | ? | |
| 1921 | L | Kentucky St. | 0 | Simmons (KY) | 39 | ? | |
| 1921 | L | Kentucky St. | 0 | West Virginia St. | 41 | ? | |
| 1921 | L | Kentucky St. | 0 | Wilberforce (OH) | 33 | ? | |
| 1921 | L | Kentucky Wesleyan | 0 | Cincinnati (OH) | 115 | Cincinnati, OH | |
| 1921 | L | Kentucky Wesleyan | 6 | Cumberland (KY) | 13 | ? | |
| 1921 | W | Kentucky Wesleyan | 6 | Cumberland (KY) | 3 | ? | |
| 1921 | T | Kentucky Wesleyan | 0 | Eastern Kentucky | 0 | Richmond, KY | |
| 1921 | L | Kentucky Wesleyan | 0 | Louisville (KY) | 30 | Louisville, KY | |
| 1921 | L | Kentucky Wesleyan | 0 | Transylvania (KY) | 37 | Winchester, KY | |
| 1921 | L | Kentucky Wesleyan | 0 | Kentucky | 68 | Lexington, KY | |
| 1921 | L | Kentucky Wesleyan | 0 | Georgetown (KY) | 33 | Winchester, KY | |
| 1921 | L | Kentucky Wesleyan | 0 | Charleston (WV) | 27 | Barboursville, WV | |
| 1921 | L | Kenyon (OH) | 0 | Case Institute of Technology (OH) | 28 | Cleveland, OH | |
| 1921 | T | Kenyon (OH) | 0 | Mount Union (OH) | 0 | Alliance, OH | |
| 1921 | T | Kenyon (OH) | 7 | Otterbein (OH) | 7 | Westerville, OH | |
| 1921 | W | Kenyon (OH) | 3 | Wooster (OH) | 0 | Gambier, OH | |
| 1921 | T | Kenyon (OH) | 0 | Wittenberg (OH) | 0 | Springfield, OH | |
| 1921 | T | Kenyon (OH) | 7 | Muskingum (OH) | 7 | Gambier, OH | |
| 1921 | T | Kenyon (OH) | 0 | Hiram (OH) | 0 | Hiram, OH | |
| 1921 | L | Kenyon HS (MN) | 0 | Faribault HS (MN) | 31 | ? | |
| 1921 | W | Keokuk HS (IA) | 7 | Carthage HS (IL) | 0 | ? | |
| 1921 | L | Keokuk HS (IA) | 0 | Centerville HS (IA) | 7 | ? | |
| 1921 | L | Keokuk HS (IA) | 0 | Fairfield HS (IA) | 14 | ? | |
| 1921 | W | Keokuk HS (IA) | 7 | Fort Madison HS (IA) | 6 | ? | |
| 1921 | T | Keokuk HS (IA) | 6 | Keosauqua HS (IA) | 6 | ? | |
| 1921 | L | Keokuk HS (IA) | 0 | Milton HS (IA) | 14 | ? | |
| 1921 | W | Keokuk HS (IA) | 7 | Mount Pleasant HS (IA) | 0 | ? | |
| 1921 | W | Keokuk HS (IA) | 2 | Quincy HS (IL) | 0 | ? | |
| 1921 | W | Keokuk HS (IA) | 19 | Stronghurst HS (IL) | 13 | ? | |
| 1921 | T | Keosauqua HS (IA) | 6 | Keokuk HS (IA) | 6 | ? | |
| 1921 | L | Keota HS (OK) | 0 | Van Buren HS (AR) | 34 | ? | |
| 1921 | T | Kern County HS (CA) | 0 | Berkeley HS (CA) | 0 | ? | |
| 1921 | W | Kern County HS (CA) | 63 | California Freshmen | 0 | ? | |
| 1921 | W | Kern County HS (CA) | 27 | Dinuba HS (CA) | 0 | ? | |
| 1921 | W | Kern County HS (CA) | 34 | Fresno HS (CA) | 7 | ? | |
| 1921 | W | Kern County HS (CA) | 23 | Fullerton HS (CA) | 18 | ? | |
| 1921 | W | Kern County HS (CA) | 70 | Los Angeles Poly HS (CA) | 0 | ? | |
| 1921 | W | Kern County HS (CA) | 42 | Occidental Freshmen (CA) | 0 | ? | |
| 1921 | W | Kern County HS (CA) | 27 | Pomona HS (CA) | 0 | ? | |
| 1921 | W | Kern County HS (CA) | 42 | Porterville HS (CA) | 7 | ? | |
| 1921 | W | Kern County HS (CA) | 35 | Santa Ana HS (CA) | 7 | ? | |
| 1921 | L | Kewanee HS (IL) | 0 | Canton HS (IL) | 6 | ? | |
| 1921 | L | Kewanee HS (IL) | 14 | Galesburg HS (IL) | 28 | ? | |
| 1921 | W | Kewanee HS (IL) | 19 | Galva HS (IL) | 3 | ? | |
| 1921 | L | Kewanee HS (IL) | 7 | Geneseo HS (IL) | 20 | ? | |
| 1921 | L | Kewanee HS (IL) | 0 | LaSalle-Peru HS (IL) | 72 | ? | |
| 1921 | L | Kewanee HS (IL) | 0 | Mendota HS (IL) | 20 | ? | |
| 1921 | L | Kewanee HS (IL) | 7 | Monmouth HS (IL) | 32 | ? | |
| 1921 | W | Kewanee HS (IL) | 45 | Neponset HS (IL) | 0 | ? | |
| 1921 | W | Keyser Prep School (WV) | 21 | Fairmont St. (WV) | 7 | ? | |
| 1921 | W | Keyser Prep School (WV) | 42 | Thomas HS (WV) | 0 | ? | |
| 1921 | W | Keyser Prep School (WV) | 27 | Thomas HS (WV) | 7 | ? | |
| 1921 | L | Keystone Academy (PA) | 7 | Wilkes-Barre HS (PA) | 13 | ? | |
| 1921 | W | Keystone Academy (PA) | 6 | Bloomsburg (PA) | 0 | Factoryville, PA | |
| 1921 | L | Killingly HS (CT) | 6 | New London Vocational HS (CT) | 44 | ? | |
| 1921 | L | Kimball Union Academy (NH) | 0 | Colby Academy (NH) | 28 | ? | |
| 1921 | L | Kimberley HS | 0 | Filer HS (ID) | 75 | ? | |
| 1921 | L | King College (TN) | 14 | Carson-Newman (TN) | 17 | Jefferson City, TN | |
| 1921 | W | King College (TN) | 35 | East Tennessee St. | 0 | Johnson City, TN | |
| 1921 | L | King College (TN) | 7 | Emory & Henry (VA) | 19 | Bristol, TN | |
| 1921 | W | King College (TN) | 7 | Roanoke (VA) | 0 | Bristol, TN | |
| 1921 | W | King College (TN) | 28 | Tusculum (TN) | 0 | Greeneville, TN | |
| 1921 | W | King College (TN) | 42 | East Tennessee St. | 7 | Bristol, TN | |
| 1921 | W | King College (TN) | 54 | Washington College Academy (TN) | 0 | Bristol, TN | |
| 1921 | L | Kingfisher (OK) | 13 | Central Oklahoma | 21 | ? | |
| 1921 | W | Kingfisher (OK) | 32 | East Central (OK) | 0 | Ada, OK | |
| 1921 | L | Kingfisher (OK) | 0 | Oklahoma Baptist University | 6 | Shawnee, OK | |
| 1921 | L | Kingfisher (OK) | 0 | Southwestern Oklahoma St. | 14 | ? | |
| 1921 | L | Kingfisher (OK) | 7 | Tulsa (OK) | 24 | Tulsa, OK | |
| 1921 | L | Kingfisher (OK) | 7 | Phillips (OK) | 42 | Enid, OK | |
| 1921 | W | Kingfisher (OK) | 20 | Oklahoma City (OK) | 9 | Kingfisher, OK | |
| 1921 | W | Kingman HS (KS) | 59 | Anthony HS (KS) | 0 | ? | |
| 1921 | W | Kingman HS (KS) | 54 | Conway Springs HS (KS) | 6 | ? | |
| 1921 | W | Kingman HS (KS) | 73 | Nickerson HS (KS) | 0 | ? | |
| 1921 | W | Kingman HS (KS) | 20 | Pratt HS (KS) | 0 | ? | |
| 1921 | W | Kingman HS (KS) | 46 | Saint John HS (KS) | 0 | ? | |
| 1921 | W | Kingman HS (KS) | 102 | Salina HS (KS) | 0 | ? | |
| 1921 | W | Kingman HS (KS) | 40 | Stafford HS (KS) | 0 | ? | |
| 1921 | W | Kingman HS (KS) | 50 | Wellington HS (KS) | 0 | ? | |
| 1921 | W | Kingman HS (KS) | 47 | Wichita HS (KS) | 0 | ? | |
| 1921 | W | Kingston Academy (NY) | 7 | Brooklyn Evening HS (NY) | 0 | ? | |
| 1921 | L | Kingston HS (NY) | 0 | Albany HS (NY) | 34 | ? | |
| 1921 | T | Kingston HS (NY) | 7 | Albany HS (NY) | 7 | ? | |
| 1921 | T | Kingston HS (NY) | 0 | Poughkeepsie HS (NY) | 0 | ? | |
| 1921 | T | Kingston HS (NY) | 0 | Poughkeepsie HS (NY) | 0 | ? | |
| 1921 | L | Kingston HS (NY) | 0 | Saratoga Springs HS (NY) | 7 | ? | |
| 1921 | L | Kingston HS (RI) | 7 | Westerly HS (RI) | 20 | ? | |
| 1921 | L | Kingwood HS | 7 | Morgantown HS (WV) | 34 | ? | |
| 1921 | T | Kinston HS (NC) | 7 | New Hanover HS (NC) | 7 | ? | |
| 1921 | L | Kinston HS (NC) | 7 | New Hanover HS (NC) | 34 | ? | |
| 1921 | L | Kirbyville HS (TX) | 0 | Orange HS (TX) | 21 | ? | |
| 1921 | W | Kirksville Osteopath (MO) | 21 | Central (IA) | 0 | Kirksville, MO | |
| 1921 | W | Kirksville Osteopath (MO) | 40 | Missouri Military Academy | 0 | ? | |
| 1921 | W | Kirksville Osteopath (MO) | 19 | Saint Ambrose (IA) | 0 | Kirksville, MO | |
| 1921 | W | Kirksville Osteopath (MO) | 28 | Truman St. (MO) | 6 | Kirksville, MO | |
| 1921 | L | Kirksville Osteopath (MO) | 0 | Texas Christian | 7 | Fort Worth, TX | |
| 1921 | W | Kirksville Osteopath (MO) | 41 | Chillicothe Business College (MO) | 0 | Kirksville, MO | |
| 1921 | W | Kirksville Osteopath (MO) | 42 | Lake Forest (IL) | 7 | Kirksville, MO | |
| 1921 | W | Kiski Academy (PA) | 19 | Cornell Freshmen (NY) | 0 | ? | |
| 1921 | T | Kiski Academy (PA) | 0 | Penn St. Freshmen | 0 | ? | |
| 1921 | L | Kiski Academy (PA) | 0 | Pittsburgh Freshmen (PA) | 9 | ? | |
| 1921 | W | Kiski Academy (PA) | 35 | Princeton Freshmen (NJ) | 0 | ? | |
| 1921 | W | Kiski Academy (PA) | 14 | Slippery Rock (PA) | 0 | ? | |
| 1921 | T | Kiski Academy (PA) | 0 | Washington & Jefferson JV (PA) | 0 | ? | |
| 1921 | W | Kiski Academy (PA) | 38 | West Virginia Freshmen | 0 | ? | |
| 1921 | L | Kittrell College (NC) | 0 | Saint Paul's (VA) | 33 | ? | |
| 1921 | L | Kittrell College (NC) | 0 | Virginia-Lynchburg | 72 | ? | |
| 1921 | W | Klamath Falls HS (OR) | 17 | Ashland HS (OR) | 7 | ? | |
| 1921 | L | Klamath Falls HS (OR) | 7 | Ashland HS (OR) | 23 | ? | |
| 1921 | L | Knox (IL) | 7 | Beloit (WI) | 13 | Beloit, WI | |
| 1921 | L | Knox (IL) | 7 | Carleton (MN) | 13 | Galesburg, IL | |
| 1921 | W | Knox (IL) | 34 | Hedding (IL) | 0 | Galesburg, IL | |
| 1921 | L | Knox (IL) | 0 | Lombard (IL) | 14 | Galesburg, IL | |
| 1921 | L | Knox (IL) | 0 | Millikin (IL) | 7 | Galesburg, IL | |
| 1921 | W | Knox (IL) | 17 | Monmouth (IL) | 7 | Galesburg, IL | |
| 1921 | L | Knox (IL) | 14 | Iowa | 52 | Iowa City, IA | |
| 1921 | L | Knox (IL) | 7 | Illinois Wesleyan | 12 | Bloomington, IL | |
| 1921 | L | Knox (IL) | 0 | Coe (IA) | 38 | Cedar Rapids, IA | |
| 1921 | L | Knox County Central HS (TN) | 0 | Tennessee Military Institute | 7 | ? | |
| 1921 | W | Knox Institute (GA) | 10 | Clark Atlanta (GA) | 0 | ? | |
| 1921 | W | Knox JV (IL) | 6 | Western Illinois | 0 | Macomb, IL | |
| 1921 | L | Knoxville (TN) | 0 | Clark Atlanta (GA) | 10 | ? | |
| 1921 | L | Knoxville (TN) | 0 | Morehouse (GA) | 13 | ? | |
| 1921 | L | Knoxville Central HS (TN) | 6 | Cumberland (KY) | 13 | ? | |
| 1921 | L | Knoxville Central HS (TN) | 0 | Maryville (TN) | 27 | Maryville, TN | |
| 1921 | W | Knoxville HS (PA) | 32 | Ben Avon HS (PA) | 0 | ? | |
| 1921 | W | Knoxville HS (TN) | 21 | Asheville HS (NC) | 9 | ? | |
| 1921 | L | Knoxville HS (TN) | 12 | Baylor Military Academy (TN) | 35 | ? | |
| 1921 | L | Knoxville HS (TN) | 0 | Tennessee Military Institute | 7 | ? | |
| 1921 | L | Kosciusko HS (MS) | 7 | Grenada HS (MS) | 53 | ? | |
| 1921 | L | La Crosse HS (WI) | 0 | Winona St. (MN) | 49 | ? | |
| 1921 | L | La Grande HS (OR) | 0 | Pendleton HS (OR) | 13 | ? | |
| 1921 | W | La Junta HS (CO) | 7 | Fowler HS (CO) | 0 | ? | |
| 1921 | T | La Junta HS (CO) | 7 | Lamar HS (CO) | 7 | ? | |
| 1921 | W | La Junta HS (CO) | 7 | Las Animas HS (CO) | 0 | ? | |
| 1921 | W | La Junta HS (CO) | 26 | Ordway HS (CO) | 0 | ? | |
| 1921 | L | La Junta HS (CO) | 0 | Pueblo Centennial HS (CO) | 7 | ? | |
| 1921 | L | La Junta HS (CO) | 7 | Pueblo Central HS (CO) | 20 | ? | |
| 1921 | T | La Junta HS (CO) | 9 | Rocky Ford HS (CO) | 9 | ? | |
| 1921 | W | La Junta HS (CO) | 7 | Rocky Ford HS (CO) | 6 | ? | |
| 1921 | L | La Junta HS (CO) | 6 | Trinidad HS (CO) | 9 | ? | |
| 1921 | W | La Salle Academy | 17 | Providence (RI) | 12 | Providence, RI | Hope High School |
| 1921 | T | La Salle Prep | 0 | Fall River Durfee HS (MA) | 0 | ? | |
| 1921 | W | La Salle Prep School (PA) | 12 | Atlantic City HS (NJ) | 0 | ? | |
| 1921 | W | La Salle Prep School (PA) | 48 | Brown Prep School (PA) | 0 | ? | |
| 1921 | L | La Salle Prep School (PA) | 6 | La Grange HS (IL) | 7 | ? | |
| 1921 | W | La Salle Prep School (PA) | 14 | Morristown HS (NJ) | 0 | ? | |
| 1921 | W | La Salle Prep School (PA) | 14 | Norristown HS (PA) | 0 | ? | |
| 1921 | W | La Salle Prep School (PA) | 15 | Philadelphia Southern Manual Training HS (PA) | 0 | ? | |
| 1921 | W | La Salle Prep School (PA) | 18 | Wenonah Military Academy (NJ) | 0 | ? | |
| 1921 | W | La Salle Prep School (PA) | 3 | Woodbury HS (NJ) | 0 | ? | |
| 1921 | L | La Verne (CA) | 0 | Fresno St. (CA) | 46 | ? | |
| 1921 | L | La Verne (CA) | 0 | Loyola Marymount (CA) | 33 | ? | |
| 1921 | T | Laconia HS (NH) | 0 | Tilton Seminary (NH) | 0 | ? | |
| 1921 | W | Lafayette (PA) | 20 | Bucknell (PA) | 7 | Lewisburg, PA | |
| 1921 | W | Lafayette (PA) | 28 | Fordham (NY) | 7 | New York, NY | |
| 1921 | W | Lafayette (PA) | 28 | Lehigh (PA) | 6 | Bethlehem, PA | |
| 1921 | W | Lafayette (PA) | 48 | Muhlenberg (PA) | 0 | Easton, PA | |
| 1921 | W | Lafayette (PA) | 35 | Rutgers (NJ) | 0 | Easton, PA | |
| 1921 | W | Lafayette (PA) | 6 | Pittsburgh (PA) | 0 | Easton, PA | |
| 1921 | W | Lafayette (PA) | 38 | Pennsylvania | 6 | Philadelphia, PA | |
| 1921 | W | Lafayette (PA) | 27 | Dickinson (PA) | 0 | Easton, PA | |
| 1921 | W | Lafayette (PA) | 44 | Delaware | 0 | Easton, PA | |
| 1921 | L | Lafayette Club | 0 | Benedictine (IL) | 38 | Lisle, IL | |
| 1921 | L | Lafayette Freshmen (PA) | 0 | Allentown Prep School (PA) | 3 | ? | |
| 1921 | L | Lafayette Freshmen (PA) | 7 | Blair Hall Academy (NJ) | 14 | ? | |
| 1921 | L | Lafayette Freshmen (PA) | 0 | Delaware Valley (PA) | 7 | ? | |
| 1921 | W | Lafayette Freshmen (PA) | 18 | East Stroudsburg (PA) | 7 | ? | |
| 1921 | L | Lake Charles HS (LA) | 0 | Baton Rouge HS (LA) | 13 | ? | |
| 1921 | L | Lake City HS (FL) | 0 | Charleston HS (SC) | 68 | ? | |
| 1921 | L | Lake City HS (FL) | 0 | Jacksonville Duval HS (FL) | 77 | ? | |
| 1921 | L | Lake City HS (MN) | 0 | Red Wing HS (MN) | 66 | ? | |
| 1921 | L | Lake City HS (MN) | 0 | Rochester HS (MN) | 1 | ? | Lake City HS Forfeits |
| 1921 | W | Lake Forest (IL) | 10 | Millikin (IL) | 3 | Decatur, IL | |
| 1921 | W | Lake Forest (IL) | 26 | Monmouth (IL) | 0 | Lake Forest, IL | |
| 1921 | L | Lake Forest (IL) | 0 | North Central (IL) | 7 | Naperville, IL | |
| 1921 | W | Lake Forest (IL) | 28 | Wheaton (IL) | 0 | Wheaton, IL | |
| 1921 | W | Lake Forest (IL) | 26 | DePaul (IL) | 7 | Chicago, IL | |
| 1921 | L | Lake Forest (IL) | 14 | Beloit (WI) | 21 | Lake Forest, IL | |
| 1921 | L | Lake Forest (IL) | 0 | Chicago YMCA College (IL) | 7 | Lake Forest, IL | |
| 1921 | L | Lake Forest (IL) | 7 | Kirksville Osteopath (MO) | 42 | Kirksville, MO | |
| 1921 | W | Lake Forest Academy (IL) | 34 | Culver Military Academy (IN) | 7 | Culver, IN | |
| 1921 | W | Lake Forest Academy (IL) | 21 | Marquette Academy (WI) | 0 | ? | |
| 1921 | L | Lake Linden HS (MI) | 6 | Calumet HS (MI) | 46 | ? | |
| 1921 | L | Lake Linden HS (MI) | 0 | Calumet HS (MI) | 48 | ? | |
| 1921 | L | Lake Providence HS (LA) | 0 | Greenville HS (MS) | 54 | ? | |
| 1921 | L | Lakewood HS (NJ) | 0 | Asbury Park HS (NJ) | 6 | ? | |
| 1921 | W | Lakewood HS (NJ) | 7 | Freehold HS (NJ) | 6 | ? | |
| 1921 | L | Lakewood HS (NJ) | 7 | Long Branch Chattle HS (NJ) | 13 | ? | |
| 1921 | W | Lakewood HS (NJ) | 21 | Mount Holly HS (NJ) | 7 | ? | |
| 1921 | T | Lakewood HS (NJ) | 7 | Neptune HS (NJ) | 7 | ? | |
| 1921 | W | Lakewood HS (NJ) | 21 | Point Pleasant HS (NJ) | 6 | ? | |
| 1921 | W | Lakewood HS (NJ) | 7 | Princeton HS (NJ) | 0 | ? | |
| 1921 | W | Lakewood HS (NJ) | 54 | Toms River HS (NJ) | 0 | ? | |
| 1921 | W | Lakewood HS (OH) | 39 | Cleveland Heights HS (OH) | 6 | ? | |
| 1921 | W | Lakewood HS (OH) | 32 | Cleveland Lincoln HS (OH) | 6 | ? | |
| 1921 | T | Lakewood HS (OH) | 6 | Cleveland University School (OH) | 6 | ? | |
| 1921 | L | Lakewood HS (OH) | 6 | East Cleveland Shaw HS (OH) | 17 | ? | |
| 1921 | W | Lakewood HS (OH) | 33 | Erie Central HS (PA) | 0 | ? | |
| 1921 | W | Lakewood HS (OH) | 44 | Lorain HS (OH) | 0 | ? | |
| 1921 | W | Lakewood HS (OH) | 68 | Medina HS (OH) | 0 | ? | |
| 1921 | W | Lakewood HS (OH) | 13 | Oberlin HS (OH) | 7 | ? | |
| 1921 | L | Lakewood HS (OH) | 14 | Toledo Waite HS (OH) | 27 | ? | |
| 1921 | L | Lamar HS (CO) | 0 | Colorado Springs HS (CO) | 10 | ? | |
| 1921 | T | Lamar HS (CO) | 7 | La Junta HS (CO) | 7 | ? | |
| 1921 | L | Lamberton HS (MN) | 0 | Sleepy Eye HS (MN) | 108 | ? | |
| 1921 | W | Lambertville HS (NJ) | 6 | Bristol HS (PA) | 0 | ? | |
| 1921 | W | Lambertville HS (NJ) | 12 | Flemington HS (NJ) | 7 | ? | |
| 1921 | L | Lambertville HS (NJ) | 6 | Flemington HS (NJ) | 28 | ? | |
| 1921 | L | Lambertville HS (NJ) | 0 | New Jersey (NJ) | 38 | ? | |
| 1921 | L | Lambertville HS (NJ) | 0 | Phillipsburg HS (NJ) | 35 | ? | |
| 1921 | L | Lambertville HS (NJ) | 0 | Princeton HS (NJ) | 6 | ? | |
| 1921 | L | Lambertville HS (NJ) | 0 | Trenton HS (NJ) | 26 | ? | |
| 1921 | L | Lancaster HS | 0 | Harvard Military School (CA) | 53 | ? | |
| 1921 | W | Lancaster HS (OH) | 12 | Chillicothe HS (OH) | 7 | ? | |
| 1921 | W | Lancaster HS (OH) | 6 | Columbus South HS (OH) | 0 | ? | |
| 1921 | W | Lancaster HS (PA) | 28 | Allentown Prep School (PA) | 0 | ? | |
| 1921 | L | Lancaster HS (PA) | 3 | Coatesville HS (PA) | 7 | ? | |
| 1921 | W | Lancaster HS (PA) | 10 | Delaware Valley (PA) | 0 | ? | |
| 1921 | W | Lancaster HS (PA) | 98 | Gettysburg Academy (PA) | 0 | ? | |
| 1921 | W | Lancaster HS (PA) | 37 | Lebanon Valley JV (PA) | 0 | ? | |
| 1921 | W | Lancaster HS (PA) | 35 | Mount Carmel HS (PA) | 7 | ? | |
| 1921 | W | Lancaster HS (PA) | 34 | Pottsville HS (PA) | 0 | ? | |
| 1921 | W | Lancaster HS (PA) | 49 | Waynesboro Business College (PA) | 0 | ? | |
| 1921 | W | Lancaster HS (PA) | 21 | York HS (PA) | 0 | ? | |
| 1921 | W | Lane (TN) | 20 | East Saint Louis Lincoln HS (IL) | 2 | ? | |
| 1921 | W | Lane (TN) | 7 | Mississippi Industrial Training School | 0 | ? | |
| 1921 | W | Lane (TN) | 7 | Tennessee St. | 0 | ? | |
| 1921 | W | Lanesboro HS (MN) | 61 | Chatfield HS (MN) | 0 | ? | |
| 1921 | L | Lanesboro HS (MN) | 21 | Cresco HS (IA) | 32 | ? | |
| 1921 | W | Lanesboro HS (MN) | 41 | Preston HS (MN) | 0 | ? | |
| 1921 | W | Lanesboro HS (MN) | 26 | Rushford HS (MN) | 0 | ? | |
| 1921 | W | Lanesboro HS (MN) | 63 | Rushford HS (MN) | 0 | ? | |
| 1921 | W | Lanesboro HS (MN) | 14 | Spring Valley HS (MN) | 0 | ? | |
| 1921 | W | Lanesboro HS (MN) | 28 | Spring Valley HS (MN) | 0 | ? | |
| 1921 | L | Lansdale HS (PA) | 0 | Abington HS (PA) | 7 | ? | |
| 1921 | W | Lansdale HS (PA) | 28 | Palmyra HS (NJ) | 7 | ? | |
| 1921 | L | Lansdale HS (PA) | 7 | Quakertown HS (PA) | 24 | ? | |
| 1921 | W | Lansdowne HS (PA) | 28 | Darby HS (PA) | 0 | ? | |
| 1921 | W | Lansdowne HS (PA) | 21 | Lower Merion HS (PA) | 0 | ? | |
| 1921 | W | Lansdowne HS (PA) | 35 | Media HS (PA) | 0 | ? | |
| 1921 | L | Lansdowne HS (PA) | 6 | Penn Charter School (PA) | 7 | ? | |
| 1921 | W | Lansdowne HS (PA) | 7 | Radnor HS (PA) | 0 | ? | |
| 1921 | W | Lansdowne HS (PA) | 28 | Ridley Park HS (PA) | 0 | ? | |
| 1921 | W | Lansdowne HS (PA) | 84 | Swarthmore HS (PA) | 0 | ? | |
| 1921 | L | Lansford HS (PA) | 0 | Allentown HS (PA) | 46 | ? | |
| 1921 | L | Lansford HS (PA) | 0 | Bethlehem HS (PA) | 76 | ? | |
| 1921 | L | Lansford HS (PA) | 7 | Easton HS (PA) | 56 | ? | |
| 1921 | W | Lansing HS (MI) | 26 | Albion HS (MI) | 7 | ? | |
| 1921 | T | Lansing HS (MI) | 14 | Ann Arbor HS (MI) | 14 | ? | |
| 1921 | W | Lansing HS (MI) | 27 | Battle Creek HS (MI) | 0 | ? | |
| 1921 | W | Lansing HS (MI) | 35 | Detroit Central HS (MI) | 0 | ? | |
| 1921 | W | Lansing HS (MI) | 26 | Dowagiac HS (MI) | 0 | ? | |
| 1921 | W | Lansing HS (MI) | 21 | Grand Rapids Union HS (MI) | 6 | ? | |
| 1921 | W | Lansing HS (MI) | 14 | Jackson HS (MI) | 0 | ? | |
| 1921 | L | Lansing HS (MI) | 0 | Michigan St. Freshmen | 21 | ? | |
| 1921 | L | Lansing HS (MI) | 0 | Saginaw Arthur Hill HS (MI) | 14 | ? | |
| 1921 | L | Lansing HS (MI) | 0 | Saginaw East HS (MI) | 7 | ? | |
| 1921 | L | Lapeer HS (MI) | 6 | Saginaw Arthur Hill HS (MI) | 47 | ? | |
| 1921 | W | Laramie HS (WY) | 3 | Cheyenne HS (WY) | 0 | ? | |
| 1921 | W | Laramie HS (WY) | 10 | Cheyenne HS (WY) | 0 | ? | |
| 1921 | W | Laramie HS (WY) | 36 | Colorado St. JV | 6 | ? | Colorado St. JV in question |
| 1921 | L | Laramie HS (WY) | 13 | Fort Collins HS (CO) | 20 | ? | |
| 1921 | L | Laramie HS (WY) | 0 | Sheridan HS (WY) | 20 | ? | |
| 1921 | W | Laramie HS (WY) | 52 | University School | 0 | ? | |
| 1921 | L | Las Animas HS (CO) | 0 | La Junta HS (CO) | 7 | ? | |
| 1921 | T | Las Animas HS (CO) | 6 | Trinidad HS (CO) | 6 | ? | |
| 1921 | T | Las Cruces HS (NM) | 0 | El Paso HS (TX) | 0 | ? | |
| 1921 | W | LaSalle-Peru HS (IL) | 7 | Hall | 6 | ? | |
| 1921 | W | LaSalle-Peru HS (IL) | 72 | Kewanee HS (IL) | 0 | ? | |
| 1921 | W | LaSalle-Peru HS (IL) | 14 | Mendota HS (IL) | 3 | ? | |
| 1921 | L | LaSalle-Peru HS (IL) | 14 | Moline HS (IL) | 17 | ? | |
| 1921 | W | LaSalle-Peru HS (IL) | 82 | Momence HS (IL) | 14 | ? | |
| 1921 | W | LaSalle-Peru HS (IL) | 21 | Ottawa HS (IL) | 0 | ? | |
| 1921 | L | LaSalle-Peru HS (IL) | 0 | Peoria Central HS (IL) | 16 | ? | |
| 1921 | W | LaSalle-Peru HS (IL) | 20 | Princeton HS (IL) | 7 | ? | |
| 1921 | L | Latrobe HS (PA) | 0 | Washington HS (PA) | 41 | ? | |
| 1921 | L | Latrobe HS (PA) | 6 | Wilkinsburg HS (PA) | 13 | ? | |
| 1921 | W | Latter Day Saints HS (UT) | 19 | Ogden HS (UT) | 6 | ? | |
| 1921 | L | Latter Day Saints HS (UT) | 7 | Salt Lake City East Side HS (UT) | 114 | ? | |
| 1921 | W | Lawrence (WI) | 36 | Beloit (WI) | 0 | Appleton, WI | |
| 1921 | W | Lawrence (WI) | 6 | Carroll (WI) | 0 | Waukesha, WI | |
| 1921 | W | Lawrence (WI) | 26 | Northwestern (WI) | 6 | Watertown, WI | |
| 1921 | L | Lawrence (WI) | 0 | Wisconsin-Oshkosh | 3 | Appleton, WI | |
| 1921 | L | Lawrence (WI) | 0 | Wisconsin | 28 | Madison, WI | |
| 1921 | W | Lawrence (WI) | 22 | Wisconsin-Stevens Point | 0 | Appleton, WI | |
| 1921 | W | Lawrence (WI) | 7 | Ripon (WI) | 3 | Appleton, WI | |
| 1921 | L | Lawrence HS (MA) | 0 | Fitchburg HS (MA) | 16 | ? | |
| 1921 | L | Lawrence HS (MA) | 6 | Haverhill HS (MA) | 14 | ? | |
| 1921 | L | Lawrence HS (MA) | 7 | Manchester HS (NH) | 27 | ? | |
| 1921 | L | Lawrence HS (MA) | 0 | Medford HS (MA) | 26 | ? | |
| 1921 | L | Lawrence HS (MA) | 0 | Peabody HS (MA) | 21 | ? | |
| 1921 | W | Lawrence HS (MA) | 40 | Punchard HS (MA) | 6 | ? | |
| 1921 | L | Lawrence HS (NY) | 6 | New York Morris HS (NY) | 7 | ? | |
| 1921 | L | Lawrence HS (NY) | 3 | Port Washington HS (NY) | 19 | ? | |
| 1921 | L | Lawrence JV (WI) | 14 | Saint John's Military Academy (WI) | 34 | ? | |
| 1921 | L | Lawrenceville School (NJ) | 0 | East Orange HS (NJ) | 6 | ? | |
| 1921 | W | Lawrenceville School (NJ) | 10 | Hill School (PA) | 7 | ? | |
| 1921 | W | Lawrenceville School (NJ) | 26 | Newark Barringer HS (NJ) | 0 | ? | |
| 1921 | L | Lawrenceville School (NJ) | 7 | Peddie Institute (NJ) | 14 | ? | |
| 1921 | W | Lawrenceville School (NJ) | 33 | Perkiomen Seminary (PA) | 6 | ? | |
| 1921 | W | Lawrenceville School (NJ) | 14 | Princeton Prep School (NJ) | 0 | ? | |
| 1921 | W | Lawrenceville School (NJ) | 35 | Tome Institute (MD) | 0 | ? | |
| 1921 | L | Lawton HS (OK) | 7 | Oklahoma City HS (OK) | 21 | ? | |
| 1921 | L | Lawton HS (OK) | 0 | Sapulpa HS (OK) | 49 | ? | |
| 1921 | L | Lead HS (SD) | 0 | Belle Fourche HS (SD) | 7 | ? | |
| 1921 | W | Lead HS (SD) | 14 | Belle Fourche HS (SD) | 12 | ? | |
| 1921 | W | Lead HS (SD) | 13 | Black Hills St. (SD) | 0 | ? | |
| 1921 | L | Lead HS (SD) | 0 | Deadwood HS (SD) | 6 | ? | |
| 1921 | W | Lead HS (SD) | 37 | Deadwood HS (SD) | 0 | ? | |
| 1921 | L | Lead HS (SD) | 0 | Hot Springs HS (SD) | 7 | ? | |
| 1921 | W | Lead HS (SD) | 33 | Hot Springs HS (SD) | 0 | ? | |
| 1921 | L | Lebanon HS (OR) | 7 | Ashland HS (OR) | 38 | ? | |
| 1921 | L | Lebanon HS (PA) | 0 | Easton HS (PA) | 7 | ? | |
| 1921 | W | Lebanon HS (PA) | 11 | Norristown HS (PA) | 7 | ? | |
| 1921 | L | Lebanon HS (PA) | 2 | Williamsport HS (PA) | 6 | ? | |
| 1921 | T | Lebanon Valley (PA) | 21 | Muhlenberg (PA) | 21 | Allentown, PA | |
| 1921 | L | Lebanon Valley (PA) | 0 | Penn St. | 53 | State College, PA | |
| 1921 | W | Lebanon Valley (PA) | 6 | Saint John's (MD) | 0 | Annapolis, MD | |
| 1921 | L | Lebanon Valley (PA) | 0 | Susquehanna (PA) | 2 | Sunbury, PA | |
| 1921 | L | Lebanon Valley (PA) | 7 | Villanova (PA) | 41 | Norristown, PA | |
| 1921 | L | Lebanon Valley (PA) | 0 | Georgetown (DC) | 7 | Washington, DC | |
| 1921 | W | Lebanon Valley (PA) | 34 | Juniata (PA) | 0 | Huntingdon, PA | |
| 1921 | L | Lebanon Valley (PA) | 0 | Army (NY) | 33 | West Point, NY | |
| 1921 | L | Lebanon Valley (PA) | 7 | Lehigh (PA) | 55 | Bethlehem, PA | |
| 1921 | L | Lebanon Valley JV (PA) | 0 | Lancaster HS (PA) | 37 | ? | |
| 1921 | T | Lebanon Valley JV (PA) | 0 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | L | Lebanon Valley JV (PA) | 0 | Shippensburg (PA) | 33 | Shippensburg, PA | |
| 1921 | L | Lehi HS (UT) | 13 | Westminster College (UT) | 21 | ? | |
| 1921 | L | Lehigh (PA) | 6 | Lafayette (PA) | 28 | Bethlehem, PA | |
| 1921 | L | Lehigh (PA) | 7 | Penn St. | 28 | State College, PA | |
| 1921 | L | Lehigh (PA) | 7 | Washington & Jefferson (PA) | 14 | Bethlehem, PA | |
| 1921 | W | Lehigh (PA) | 21 | West Virginia | 14 | Bethlehem, PA | |
| 1921 | W | Lehigh (PA) | 22 | Susquehanna (PA) | 0 | Bethlehem, PA | |
| 1921 | L | Lehigh (PA) | 13 | Muhlenberg (PA) | 14 | Allentown, PA | |
| 1921 | W | Lehigh (PA) | 7 | Rutgers (NJ) | 0 | New Brunswick, NJ | |
| 1921 | W | Lehigh (PA) | 55 | Lebanon Valley (PA) | 7 | Bethlehem, PA | |
| 1921 | W | Lehigh B Team (PA) | 6 | East Stroudsburg (PA) | 2 | ? | |
| 1921 | L | Lehigh B Team (PA) | 0 | Mercersburg Academy (PA) | 14 | ? | |
| 1921 | L | Leipsic HS (OH) | 0 | Mount Cory HS (OH) | 44 | ? | |
| 1921 | L | Lenoir HS (NC) | 0 | Lenoir-Rhyne (NC) | 40 | ? | |
| 1921 | L | Lenoir-Rhyne (NC) | 0 | Asheville HS (NC) | 72 | ? | |
| 1921 | L | Lenoir-Rhyne (NC) | 14 | Charlotte University School (NC) | 33 | ? | |
| 1921 | L | Lenoir-Rhyne (NC) | 0 | Guilford (NC) | 65 | Greensboro, NC | |
| 1921 | W | Lenoir-Rhyne (NC) | 40 | Lenoir HS (NC) | 0 | ? | |
| 1921 | W | Lenoir-Rhyne (NC) | 50 | Newton HS (NC) | 0 | ? | |
| 1921 | L | Lenoir-Rhyne (NC) | 0 | Elon (NC) | 39 | Elon College, NC | |
| 1921 | T | Leominster HS (MA) | 7 | Fitchburg HS (MA) | 7 | ? | |
| 1921 | L | Leominster HS (MA) | 0 | Framingham HS (MA) | 39 | ? | |
| 1921 | W | Leominster HS (MA) | 25 | Hudson HS (MA) | 0 | ? | |
| 1921 | L | Leonardo HS (NJ) | 0 | Freehold HS (NJ) | 41 | ? | |
| 1921 | T | Leonardo HS (NJ) | 0 | Red Bank HS (NJ) | 0 | ? | |
| 1921 | L | Leonardo HS (NJ) | 0 | Red Bank HS (NJ) | 6 | ? | |
| 1921 | L | Leonia HS (NJ) | 0 | Englewood HS (NJ) | 13 | ? | |
| 1921 | L | Leonia HS (NJ) | 0 | Hackensack HS (NJ) | 40 | ? | |
| 1921 | L | Leonia HS (NJ) | 0 | Hoboken Stevens Prep HS (NJ) | 13 | ? | |
| 1921 | T | Leonia HS (NJ) | 6 | Ramsey HS (NJ) | 6 | ? | |
| 1921 | W | Leonia HS (NJ) | 7 | Union Hill HS (NJ) | 6 | ? | |
| 1921 | L | Leonia HS (NJ) | 0 | Yonkers HS (NY) | 6 | ? | |
| 1921 | L | Lewis & Clark (OR) | 7 | Pacific (OR) | 28 | Albany, OR | |
| 1921 | L | Lewiston HS (ME) | 0 | Portland HS (ME) | 7 | ? | |
| 1921 | L | Lewiston HS (MN) | 6 | Stewartville HS (MN) | 7 | ? | |
| 1921 | L | Lewiston HS (MN) | 0 | Stewartville HS (MN) | 66 | ? | |
| 1921 | L | Lewistown HS (PA) | 0 | Huntingdon HS (PA) | 101 | ? | |
| 1921 | L | Lexington HS (MA) | 7 | Wakefield HS (MA) | 14 | ? | |
| 1921 | L | Lexington HS (MA) | 0 | Woburn HS (MA) | 7 | ? | |
| 1921 | L | Lexington HS (NE) | 2 | Nebraska School of Agriculture | 27 | ? | |
| 1921 | L | Lexington Mod. (KY) | 7 | Louisville HS (KY) | 39 | ? | |
| 1921 | L | Lexington Sr. (KY) | 6 | Louisville HS (KY) | 7 | ? | |
| 1921 | W | Lima South HS (OH) | 38 | Saint Marys HS (OH) | 0 | ? | |
| 1921 | L | Lincoln (MO) | 0 | Kansas Industrial and Educational Institute | 7 | ? | |
| 1921 | L | Lincoln (MO) | 0 | Simmons (KY) | 68 | ? | |
| 1921 | W | Lincoln (PA) | 26 | Bordentown Manual Training (NJ) | 0 | Bordentown, NJ | |
| 1921 | W | Lincoln (PA) | 13 | Harrisburg YMCA (PA) | 7 | ? | |
| 1921 | W | Lincoln (PA) | 13 | Howard (DC) | 7 | Philadelphia, PA | |
| 1921 | W | Lincoln (PA) | 63 | Morgan St. (MD) | 0 | Baltimore, MD | |
| 1921 | W | Lincoln (PA) | 7 | Steelton AA (PA) | 0 | ? | |
| 1921 | W | Lincoln (PA) | 20 | Wilberforce (OH) | 6 | Lincoln, PA | |
| 1921 | W | Lincoln (PA) | 13 | Hampton (VA) | 0 | Lincoln, PA | |
| 1921 | W | Lincoln (PA) | 6 | Annapolis AC (MD) | 0 | Annapolis, MD | |
| 1921 | L | Lincoln (PA) | 0 | Virginia Union | 1 | Richmond, VA | Lincoln Forfeits |
| 1921 | L | Lincoln College (IL) | 0 | Bradley (IL) | 40 | Lincoln, IL | |
| 1921 | W | Lincoln College (IL) | 14 | Eastern Illinois | 6 | Charleston, IL | |
| 1921 | L | Lincoln College (IL) | 6 | Hedding (IL) | 54 | Abingdon, IL | |
| 1921 | L | Lincoln College (IL) | 7 | Illinois St. | 40 | Normal, IL | |
| 1921 | L | Lincoln College (IL) | 0 | Saint Viator (IL) | 80 | Bourbonnais, IL | |
| 1921 | L | Lincoln College (IL) | 0 | Carthage (WI) | 28 | Lincoln, IL | |
| 1921 | L | Lincoln HS | 0 | Country Day School (WI) | 35 | ? | |
| 1921 | W | Lincoln HS | 25 | James John HS (OR) | 0 | ? | |
| 1921 | W | Lincoln HS | 7 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | W | Lincoln HS | 20 | Western (KS) | 13 | Kansas City, MO | |
| 1921 | W | Lincoln HS (IL) | 27 | Atlanta HS (IL) | 0 | ? | |
| 1921 | W | Lincoln HS (IL) | 1 | Blue Mound HS (IL) | 0 | ? | |
| 1921 | W | Lincoln HS (IL) | 18 | Clinton HS (IL) | 7 | ? | |
| 1921 | L | Lincoln HS (IL) | 14 | Illiopolis HS (IL) | 26 | ? | |
| 1921 | L | Lincoln HS (IL) | 0 | Jacksonville HS (IL) | 21 | ? | |
| 1921 | W | Lincoln HS (IL) | 27 | McLean HS (IL) | 9 | ? | |
| 1921 | W | Lincoln HS (IL) | 7 | Normal HS (IL) | 0 | ? | |
| 1921 | W | Lincoln HS (IL) | 20 | Pekin HS (IL) | 0 | ? | |
| 1921 | L | Lincoln HS (IL) | 0 | Springfield HS (IL) | 14 | ? | |
| 1921 | W | Lincoln HS (IL) | 33 | Stonington HS (IL) | 6 | ? | |
| 1921 | W | Lincoln HS (IL) | 27 | Virginia HS (IL) | 3 | ? | |
| 1921 | W | Lincoln HS (NE) | 6 | Cambridge HS (NE) | 0 | ? | |
| 1921 | L | Lincoln HS (NE) | 6 | North Platte HS (NE) | 27 | ? | |
| 1921 | L | Lineville HS (AL) | 0 | Jacksonville St. (AL) | 48 | ? | |
| 1921 | W | Linsly Military Institute (WV) | 56 | Cameron HS (WV) | 0 | ? | |
| 1921 | W | Linsly Military Institute (WV) | 12 | Follansbee HS (WV) | 0 | ? | |
| 1921 | L | Linsly Military Institute (WV) | 0 | Martins Ferry HS (OH) | 20 | ? | |
| 1921 | W | Linsly Military Institute (WV) | 27 | Richland District HS (WV) | 0 | ? | |
| 1921 | L | Linsly Military Institute (WV) | 0 | Shady Side Academy (PA) | 8 | ? | |
| 1921 | W | Linsly Military Institute (WV) | 23 | Triadelphia HS (WV) | 0 | ? | |
| 1921 | L | Linsly Military Institute (WV) | 0 | Wheeling HS (WV) | 10 | ? | |
| 1921 | T | Lisbon HS (OH) | 13 | Alliance HS (OH) | 13 | ? | |
| 1921 | L | Lisbon HS (OH) | 0 | Warren HS (OH) | 32 | ? | |
| 1921 | L | Lisbon HS (OH) | 7 | Youngstown South HS (OH) | 48 | ? | |
| 1921 | L | Litchfield HS (MN) | 7 | Willmar HS (MN) | 64 | ? | |
| 1921 | L | Little Falls HS (MN) | 0 | Alexandria HS (MN) | 45 | ? | |
| 1921 | W | Little Falls HS (MN) | 59 | Brainerd HS (MN) | 0 | ? | |
| 1921 | W | Little Falls HS (MN) | 47 | Crosby HS (MN) | 0 | ? | |
| 1921 | W | Little Falls HS (MN) | 64 | Long Prairie HS (MN) | 0 | ? | |
| 1921 | L | Little Falls HS (MN) | 6 | Saint Cloud HS (MN) | 19 | ? | |
| 1921 | W | Little Falls HS (MN) | 17 | Saint Cloud St. (MN) | 13 | ? | |
| 1921 | W | Little Rock College (AR) | 13 | Arkansas St. | 0 | Jonesboro, AR | |
| 1921 | L | Little Rock College (AR) | 0 | Arkansas Tech | 21 | Little Rock, AR | |
| 1921 | W | Little Rock College (AR) | 19 | Central Arkansas | 0 | Conway, AR | |
| 1921 | L | Little Rock College (AR) | 0 | Ouachita Baptist (AR) | 16 | Little Rock, AR | |
| 1921 | L | Little Rock College (AR) | 13 | Ozarks (AR) | 19 | Clarksville, AR | |
| 1921 | W | Little Rock HS (AR) | 7 | Arkadelphia HS (AR) | 0 | ? | |
| 1921 | W | Little Rock HS (AR) | 75 | Camden HS (AR) | 0 | ? | |
| 1921 | W | Little Rock HS (AR) | 21 | Fort Smith HS (AR) | 0 | ? | |
| 1921 | T | Little Rock HS (AR) | 7 | Hendrix College Academy (AR) | 7 | ? | |
| 1921 | W | Little Rock HS (AR) | 34 | Memphis Central HS (TN) | 0 | ? | |
| 1921 | W | Little Rock HS (AR) | 14 | Muskogee Central HS (OK) | 7 | ? | |
| 1921 | W | Little Rock HS (AR) | 49 | Springfield Central HS (MO) | 9 | ? | |
| 1921 | W | Little Rock HS (AR) | 21 | Texarkana HS (AR) | 13 | ? | |
| 1921 | W | Little Rock HS (AR) | 21 | Warren Easton Boys HS (LA) | 3 | ? | |
| 1921 | W | Livermore HS (CA) | 31 | Mount Diablo HS (CA) | 7 | ? | |
| 1921 | W | Livermore HS (CA) | 28 | Mount Diablo HS (CA) | 14 | ? | |
| 1921 | L | Livingston Independents (MT) | 0 | Park County HS (MT) | 6 | ? | |
| 1921 | W | Livingstone (NC) | 25 | Johnson C. Smith (NC) | 6 | ? | |
| 1921 | T | Livingstone (NC) | 0 | North Carolina A&T | 0 | ? | |
| 1921 | W | Lock Haven HS (PA) | 26 | Altoona HS (PA) | 0 | ? | |
| 1921 | L | Lock Haven HS (PA) | 0 | Huntingdon HS (PA) | 1 | ? | |
| 1921 | L | Lock Haven HS (PA) | 0 | Mount Carmel HS (PA) | 6 | ? | |
| 1921 | T | Lock Haven HS (PA) | 0 | Williamsport HS (PA) | 0 | ? | |
| 1921 | L | Logan HS (UT) | 0 | Salt Lake City East Side HS (UT) | 30 | ? | |
| 1921 | W | Lombard (IL) | 7 | Des Moines (IA) | 0 | ? | |
| 1921 | W | Lombard (IL) | 14 | Knox (IL) | 0 | Galesburg, IL | |
| 1921 | W | Lombard (IL) | 90 | Monmouth (IL) | 0 | Galesburg, IL | |
| 1921 | W | Lombard (IL) | 103 | Palmer College of Chiropractic (IA) | 0 | ? | |
| 1921 | W | Lombard (IL) | 61 | Saint Louis (MO) | 0 | Saint Louis, MO | |
| 1921 | W | Lombard (IL) | 27 | Saint Viator (IL) | 7 | Galesburg, IL | |
| 1921 | W | Lombard (IL) | 54 | North Central (IL) | 7 | Naperville, IL | |
| 1921 | W | Lombard (IL) | 58 | Bradley (IL) | 0 | Peoria, IL | |
| 1921 | W | Lombard (IL) | 27 | DePaul (IL) | 0 | Chicago, IL | |
| 1921 | L | Lombard JV (IL) | 0 | Culver-Stockton (MO) | 2 | ? | |
| 1921 | L | Lon Morris (TX) | 13 | College of Marshall (TX) | 14 | ? | |
| 1921 | T | Lon Morris (TX) | 6 | Sam Houston St. (TX) | 6 | Jacksonville, TX | |
| 1921 | L | London HS (OH) | 6 | Bellefontaine HS (OH) | 7 | ? | |
| 1921 | W | London HS (OH) | 24 | Col. Academy | 0 | ? | |
| 1921 | W | London HS (OH) | 26 | Columbus HS of Commerce (OH) | 6 | ? | |
| 1921 | L | London HS (OH) | 0 | Columbus North HS (OH) | 14 | ? | |
| 1921 | W | London HS (OH) | 33 | Columbus Trades School (OH) | 12 | ? | |
| 1921 | L | London HS (OH) | 0 | Doane Academy (OH) | 20 | ? | |
| 1921 | W | London HS (OH) | 26 | Marysville HS (OH) | 7 | ? | |
| 1921 | W | London HS (OH) | 19 | Mechanicsburg HS (OH) | 0 | ? | |
| 1921 | W | London HS (OH) | 66 | Urbana HS (OH) | 0 | ? | |
| 1921 | W | London HS (OH) | 27 | Woodstock HS (OH) | 0 | ? | |
| 1921 | W | Long Beach HS (CA) | 43 | Loyola Marymount (CA) | 0 | ? | |
| 1921 | W | Long Beach HS (CA) | 7 | Sherman Indian School (CA) | 0 | ? | |
| 1921 | L | Long Branch Chattle HS (NJ) | 0 | Asbury Park HS (NJ) | 14 | ? | |
| 1921 | W | Long Branch Chattle HS (NJ) | 13 | Battin HS (NJ) | 6 | ? | |
| 1921 | L | Long Branch Chattle HS (NJ) | 7 | Freehold HS (NJ) | 20 | ? | |
| 1921 | W | Long Branch Chattle HS (NJ) | 13 | Lakewood HS (NJ) | 7 | ? | |
| 1921 | L | Long Branch Chattle HS (NJ) | 0 | Neptune HS (NJ) | 55 | ? | |
| 1921 | L | Long Branch Chattle HS (NJ) | 0 | Rutherford HS (NJ) | 35 | ? | |
| 1921 | L | Long Branch Chattle HS (NJ) | 0 | Trenton HS (NJ) | 12 | ? | |
| 1921 | L | Long Island Lawrence HS (NY) | 6 | Dover HS (NJ) | 28 | ? | |
| 1921 | W | Long Island Lawrence HS (NY) | 13 | Freeport HS (NY) | 0 | ? | |
| 1921 | L | Long Island Lawrence HS (NY) | 0 | New Utrecht HS (NY) | 7 | ? | |
| 1921 | L | Long Prairie HS (MN) | 0 | Glenwood HS (MN) | 20 | ? | |
| 1921 | L | Long Prairie HS (MN) | 0 | Little Falls HS (MN) | 64 | ? | |
| 1921 | L | Long Prairie HS (MN) | 0 | Wadena HS (MN) | 38 | ? | |
| 1921 | L | Longhorne | 0 | Bristol HS (PA) | 49 | ? | |
| 1921 | W | Longmont HS (CO) | 7 | Boulder Prep School (CO) | 3 | ? | |
| 1921 | L | Longmont HS (CO) | 0 | Colorado Springs HS (CO) | 16 | ? | |
| 1921 | W | Longmont HS (CO) | 7 | Greeley HS (CO) | 0 | ? | |
| 1921 | W | Longmont HS (CO) | 3 | Yuma County HS (CO) | 0 | ? | |
| 1921 | L | Longwood | 0 | Cleveland Central HS (OH) | 12 | ? | |
| 1921 | T | Lonoke HS (AR) | 0 | Pine Bluff HS (AR) | 0 | ? | |
| 1921 | L | Lorain HS (OH) | 0 | Lakewood HS (OH) | 44 | ? | |
| 1921 | L | Lorain HS (OH) | 0 | Sandusky HS (OH) | 6 | ? | |
| 1921 | W | Loras (IA) | 6 | Campion College (WI) | 4 | Dubuque, IA | |
| 1921 | W | Loras (IA) | 14 | DePaul (IL) | 0 | Dubuque, IA | |
| 1921 | W | Loras (IA) | 20 | Luther (IA) | 7 | Dubuque, IA | |
| 1921 | W | Loras (IA) | 42 | Mount Morris (IL) | 0 | Dubuque, IA | |
| 1921 | W | Loras (IA) | 24 | Upper Iowa | 7 | Fayette, IA | |
| 1921 | L | Loras (IA) | 6 | Wisconsin-Platteville | 7 | Platteville, WI | |
| 1921 | W | Loras (IA) | 76 | Ellsworth CC (IA) | 0 | Iowa Falls, IA | |
| 1921 | W | Loras (IA) | 20 | Wisconsin Tech | 6 | Dubuque, IA | |
| 1921 | L | Los Angeles Hollywood HS (CA) | 0 | Los Angeles Hollywood HS Alumni (CA) | 14 | ? | |
| 1921 | L | Los Angeles Hollywood HS (CA) | 10 | Los Angeles HS (CA) | 14 | ? | |
| 1921 | L | Los Angeles Hollywood HS (CA) | 7 | Los Angeles Jefferson HS (CA) | 20 | ? | |
| 1921 | W | Los Angeles Hollywood HS (CA) | 6 | Los Angeles Lincoln HS (CA) | 0 | ? | |
| 1921 | L | Los Angeles Hollywood HS (CA) | 10 | Los Angeles Manual Arts HS (CA) | 49 | ? | |
| 1921 | L | Los Angeles Hollywood HS (CA) | 3 | Los Angeles Poly HS (CA) | 21 | ? | |
| 1921 | L | Los Angeles Hollywood HS (CA) | 0 | Pasadena HS (CA) | 7 | ? | |
| 1921 | L | Los Angeles Hollywood HS (CA) | 0 | Santa Barbara HS (CA) | 7 | ? | |
| 1921 | W | Los Angeles Hollywood HS Alumni (CA) | 14 | Los Angeles Hollywood HS (CA) | 0 | ? | |
| 1921 | W | Los Angeles HS (CA) | 14 | Los Angeles Hollywood HS (CA) | 10 | ? | |
| 1921 | W | Los Angeles HS (CA) | 33 | Los Angeles Jefferson HS (CA) | 0 | ? | |
| 1921 | L | Los Angeles HS (CA) | 7 | Los Angeles Manual Arts HS (CA) | 21 | ? | |
| 1921 | W | Los Angeles HS (CA) | 26 | Pasadena HS (CA) | 12 | ? | |
| 1921 | W | Los Angeles HS (CA) | 7 | Santa Ana HS (CA) | 0 | ? | |
| 1921 | W | Los Angeles Jefferson HS (CA) | 20 | Franklin HS | 0 | ? | |
| 1921 | W | Los Angeles Jefferson HS (CA) | 20 | Los Angeles Hollywood HS (CA) | 7 | ? | |
| 1921 | L | Los Angeles Jefferson HS (CA) | 0 | Los Angeles HS (CA) | 33 | ? | |
| 1921 | L | Los Angeles Jefferson HS (CA) | 7 | Los Angeles Lincoln HS (CA) | 28 | ? | |
| 1921 | W | Los Angeles Jefferson HS (CA) | 7 | Los Angeles Manual Arts HS (CA) | 0 | ? | |
| 1921 | W | Los Angeles Jefferson HS (CA) | 14 | Los Angeles Poly HS (CA) | 13 | ? | |
| 1921 | W | Los Angeles Jefferson HS (CA) | 20 | Pasadena HS (CA) | 7 | ? | |
| 1921 | W | Los Angeles Jefferson HS (CA) | 13 | Santa Barbara HS (CA) | 0 | ? | |
| 1921 | L | Los Angeles Jefferson HS (CA) | 0 | Santa Monica HS (CA) | 42 | ? | |
| 1921 | W | Los Angeles Jefferson HS (CA) | 21 | Venice HS (CA) | 0 | ? | |
| 1921 | L | Los Angeles Lincoln HS (CA) | 0 | Los Angeles Hollywood HS (CA) | 6 | ? | |
| 1921 | W | Los Angeles Lincoln HS (CA) | 28 | Los Angeles Jefferson HS (CA) | 7 | ? | |
| 1921 | L | Los Angeles Lincoln HS (CA) | 14 | Los Angeles Manual Arts HS (CA) | 21 | ? | |
| 1921 | W | Los Angeles Lincoln HS (CA) | 21 | Pasadena HS (CA) | 14 | ? | |
| 1921 | W | Los Angeles Manual Arts HS (CA) | 49 | Los Angeles Hollywood HS (CA) | 10 | ? | |
| 1921 | W | Los Angeles Manual Arts HS (CA) | 21 | Los Angeles HS (CA) | 7 | ? | |
| 1921 | L | Los Angeles Manual Arts HS (CA) | 0 | Los Angeles Jefferson HS (CA) | 7 | ? | |
| 1921 | W | Los Angeles Manual Arts HS (CA) | 21 | Los Angeles Lincoln HS (CA) | 14 | ? | |
| 1921 | W | Los Angeles Manual Arts HS (CA) | 21 | Los Angeles Poly HS (CA) | 6 | ? | |
| 1921 | W | Los Angeles Manual Arts HS (CA) | 21 | Pasadena HS (CA) | 3 | ? | |
| 1921 | L | Los Angeles Manual Arts HS (CA) | 14 | San Diego HS (CA) | 48 | ? | |
| 1921 | L | Los Angeles Military Academy (CA) | 0 | Loyola Marymount (CA) | 21 | ? | |
| 1921 | L | Los Angeles Poly HS (CA) | 0 | Kern County HS (CA) | 70 | ? | |
| 1921 | W | Los Angeles Poly HS (CA) | 21 | Los Angeles Hollywood HS (CA) | 3 | ? | |
| 1921 | L | Los Angeles Poly HS (CA) | 13 | Los Angeles Jefferson HS (CA) | 14 | ? | |
| 1921 | L | Los Angeles Poly HS (CA) | 6 | Los Angeles Manual Arts HS (CA) | 21 | ? | |
| 1921 | L | Los Angeles Poly HS (CA) | 6 | Pasadena HS (CA) | 30 | ? | |
| 1921 | L | Los Angeles Poly HS (CA) | 0 | San Diego HS (CA) | 6 | ? | |
| 1921 | L | Louisiana American Legion (MO) | 0 | Culver-Stockton (MO) | 68 | ? | |
| 1921 | L | Louisiana College | 6 | Centenary (LA) | 7 | ? | |
| 1921 | L | Louisiana College | 0 | Louisiana-Lafayette | 46 | Lafayette, LA | |
| 1921 | L | Louisiana College | 6 | Northwestern St. (LA) | 14 | Pineville, LA | |
| 1921 | W | Louisiana College | 6 | Saint Charles (LA) | 0 | ? | |
| 1921 | L | Louisiana College | 0 | Mississippi College | 68 | Clinton, MS | |
| 1921 | T | Louisiana St. | 7 | Alabama | 7 | New Orleans, LA | |
| 1921 | W | Louisiana St. | 41 | Spring Hill (AL) | 7 | Baton Rouge, LA | |
| 1921 | W | Louisiana St. | 6 | Texas A&M | 0 | Baton Rouge, LA | |
| 1921 | L | Louisiana St. | 0 | Tulane (LA) | 21 | New Orleans, LA | |
| 1921 | W | Louisiana St. | 17 | Mississippi St. | 14 | Starkville, MS | |
| 1921 | W | Louisiana St. | 10 | Arkansas | 7 | Shreveport, LA | |
| 1921 | W | Louisiana St. | 78 | Northwestern St. (LA) | 0 | Baton Rouge, LA | |
| 1921 | W | Louisiana St. | 21 | Mississippi | 0 | Baton Rouge, LA | |
| 1921 | L | Louisiana St. Freshmen | 0 | Louisiana-Lafayette | 3 | Lafayette, LA | |
| 1921 | L | Louisiana St. JV | 0 | Louisiana-Lafayette | 3 | Lafayette, LA | |
| 1921 | W | Louisiana Tech | 13 | Arkansas-Monticello | 0 | Ruston, LA | |
| 1921 | W | Louisiana Tech | 14 | Centenary (LA) | 7 | Shreveport, LA | |
| 1921 | W | Louisiana Tech | 17 | Northwestern St. (LA) | 0 | Ruston, LA | |
| 1921 | W | Louisiana Tech | 22 | Southern Arkansas | 13 | Magnolia, AR | |
| 1921 | W | Louisiana Tech | 20 | Ouachita Baptist (AR) | 0 | Ruston, LA | |
| 1921 | W | Louisiana Tech | 20 | Louisiana-Lafayette | 0 | Ruston, LA | |
| 1921 | W | Louisiana-Lafayette | 46 | Louisiana College | 0 | Lafayette, LA | |
| 1921 | W | Louisiana-Lafayette | 3 | Louisiana St. JV | 0 | Lafayette, LA | |
| 1921 | W | Louisiana-Lafayette | 33 | Northwestern St. (LA) | 2 | Lafayette, LA | |
| 1921 | W | Louisiana-Lafayette | 26 | Patterson HS (LA) | 0 | Patterson, LA | |
| 1921 | W | Louisiana-Lafayette | 13 | Tulane JV (LA) | 7 | ? | |
| 1921 | L | Louisiana-Lafayette | 0 | Rice (TX) | 54 | Houston, TX | |
| 1921 | W | Louisiana-Lafayette | 40 | Saint Charles (LA) | 21 | Lafayette, LA | |
| 1921 | W | Louisiana-Lafayette | 20 | Loyola (LA) | 0 | New Orleans, LA | |
| 1921 | W | Louisiana-Lafayette | 35 | Jefferson (LA) | 0 | Lafayette, LA | |
| 1921 | W | Louisiana-Lafayette | 1 | Centenary (LA) | 0 | Lafayette, LA | Centenary Forfeits |
| 1921 | L | Louisiana-Lafayette | 0 | Louisiana Tech | 20 | Ruston, LA | |
| 1921 | T | Louisville (KY) | 0 | Bethel (KY) | 0 | Russellville, KY | |
| 1921 | W | Louisville (KY) | 19 | Hanover (IN) | 8 | Louisville, KY | Hanover Forfeits |
| 1921 | W | Louisville (KY) | 30 | Kentucky Wesleyan | 0 | Louisville, KY | |
| 1921 | L | Louisville (KY) | 0 | Marshall (WV) | 14 | Huntington, WV | |
| 1921 | L | Louisville (KY) | 0 | Transylvania (KY) | 7 | Lexington, KY | |
| 1921 | W | Louisville Central HS (KY) | 13 | Simmons (KY) | 7 | ? | |
| 1921 | W | Louisville HS (KY) | 19 | Elizabethtown HS (KY) | 3 | ? | |
| 1921 | W | Louisville HS (KY) | 34 | Frankfort HS (KY) | 7 | ? | |
| 1921 | W | Louisville HS (KY) | 94 | Henderson HS (KY) | 0 | ? | |
| 1921 | T | Louisville HS (KY) | 7 | Indianapolis HS (IN) | 7 | ? | |
| 1921 | W | Louisville HS (KY) | 39 | Lexington Mod. (KY) | 7 | ? | |
| 1921 | W | Louisville HS (KY) | 7 | Lexington Sr. (KY) | 6 | ? | |
| 1921 | T | Louisville HS (KY) | 0 | Louisville Manual HS (KY) | 0 | ? | |
| 1921 | W | Louisville HS (KY) | 34 | Newport HS (KY) | 0 | ? | |
| 1921 | W | Louisville HS (KY) | 21 | Owensboro HS (KY) | 0 | ? | |
| 1921 | W | Louisville HS (KY) | 21 | Winchester HS (KY) | 14 | ? | |
| 1921 | W | Louisville HS (MS) | 20 | Ackerman HS (MS) | 0 | ? | |
| 1921 | T | Louisville Manual HS (KY) | 0 | Louisville HS (KY) | 0 | ? | |
| 1921 | L | Louisville Saint Xavier HS (KY) | 0 | Cincinnati Hughes HS (OH) | 25 | ? | |
| 1921 | L | Louisville Saint Xavier HS (KY) | 0 | Elizabethtown HS (KY) | 19 | ? | |
| 1921 | W | Loveland HS (CO) | 14 | Boulder Prep School (CO) | 0 | ? | |
| 1921 | L | Loveland HS (CO) | 13 | Greeley HS (CO) | 14 | ? | |
| 1921 | L | Lowell HS (MA) | 0 | Boston College HS (MA) | 13 | ? | |
| 1921 | L | Lowell HS (MA) | 0 | Fitchburg HS (MA) | 21 | ? | |
| 1921 | L | Lowell HS (MA) | 0 | Haverhill HS (MA) | 21 | ? | |
| 1921 | L | Lowell HS (MA) | 0 | Manchester HS (NH) | 14 | ? | |
| 1921 | W | Lowell HS (MA) | 25 | Wakefield HS (MA) | 0 | ? | |
| 1921 | L | Lowell HS (MA) | 6 | Woburn HS (MA) | 12 | ? | |
| 1921 | L | Lower Merion HS (PA) | 7 | Abington HS (PA) | 21 | ? | |
| 1921 | W | Lower Merion HS (PA) | 13 | Cheltenham HS (PA) | 0 | ? | |
| 1921 | L | Lower Merion HS (PA) | 0 | Lansdowne HS (PA) | 21 | ? | |
| 1921 | L | Lower Merion HS (PA) | 7 | Lansdowne HS (PA) | 21 | ? | |
| 1921 | W | Lower Merion HS (PA) | 14 | Narberth HS (PA) | 0 | ? | |
| 1921 | L | Lower Merion HS (PA) | 0 | Philadelphia Central HS (PA) | 14 | ? | |
| 1921 | L | Lower Merion HS (PA) | 7 | Radnor HS (PA) | 21 | ? | |
| 1921 | L | Lower Merion HS (PA) | 6 | Ridley Park HS (PA) | 7 | ? | |
| 1921 | L | Lower Merion HS (PA) | 0 | Tredyffun-Easttown HS (PA) | 13 | ? | |
| 1921 | W | Lower Merion HS (PA) | 52 | Upper Darby HS (PA) | 0 | ? | |
| 1921 | L | Loyola | 3 | Chaminade College HS (MO) | 14 | ? | |
| 1921 | L | Loyola | 0 | Cleveland University School (OH) | 41 | ? | |
| 1921 | L | Loyola | 0 | Cleveland West HS (OH) | 42 | ? | |
| 1921 | W | Loyola (LA) | 27 | Jefferson (LA) | 7 | New Orleans, LA | |
| 1921 | L | Loyola (LA) | 0 | Saint Stanislaus College (MS) | 21 | Bay Saint Louis, MS | |
| 1921 | W | Loyola (LA) | 25 | Southern Mississippi | 13 | Hattiesburg, MS | |
| 1921 | L | Loyola (LA) | 7 | Spring Hill (AL) | 28 | Mobile, AL | |
| 1921 | L | Loyola (LA) | 0 | Louisiana-Lafayette | 20 | New Orleans, LA | |
| 1921 | L | Loyola (LA) | 0 | Saint Charles (LA) | 21 | New Orleans, LA | |
| 1921 | W | Loyola Academy (IL) | 20 | Chicago Nicholas Senn HS (IL) | 0 | ? | |
| 1921 | L | Loyola Academy (IL) | 0 | Culver Military Academy (IN) | 30 | ? | |
| 1921 | W | Loyola Academy (IL) | 13 | Loyola Academy Alumni (IL) | 0 | ? | |
| 1921 | T | Loyola Academy (IL) | 0 | Milwaukee Riverside HS (WI) | 0 | ? | |
| 1921 | T | Loyola Academy (IL) | 0 | Notre Dame Seniors | 0 | ? | |
| 1921 | W | Loyola Academy (IL) | 48 | Pio Nono HS (WI) | 0 | ? | |
| 1921 | W | Loyola Academy (IL) | 7 | Saint Ignatius Prep (IL) | 0 | ? | |
| 1921 | W | Loyola Academy (IL) | 14 | Saint Viator Academy | 7 | ? | |
| 1921 | L | Loyola Academy Alumni (IL) | 0 | Loyola Academy (IL) | 13 | ? | |
| 1921 | L | Loyola HS (MD) | 0 | Severn School (MD) | 14 | ? | |
| 1921 | W | Loyola Marymount (CA) | 68 | California-Santa Barbara | 0 | Santa Barbara, CA | |
| 1921 | W | Loyola Marymount (CA) | 12 | Gardena HS (CA) | 6 | ? | |
| 1921 | W | Loyola Marymount (CA) | 33 | La Verne (CA) | 0 | ? | |
| 1921 | L | Loyola Marymount (CA) | 0 | Long Beach HS (CA) | 43 | ? | |
| 1921 | W | Loyola Marymount (CA) | 21 | Los Angeles Military Academy (CA) | 0 | ? | |
| 1921 | L | Loyola Marymount (CA) | 4 | San Diego Army & Navy (CA) | 12 | ? | |
| 1921 | L | Loyola Marymount (CA) | 0 | Santa Monica All-Stars (CA) | 41 | ? | |
| 1921 | W | Loyola Marymount (CA) | 9 | Santa Monica HS (CA) | 3 | Santa Monica, CA | |
| 1921 | W | Loyola Marymount (CA) | 13 | UCLA Freshmen | 0 | ? | |
| 1921 | T | Loyola Marymount (CA) | 0 | Whittier (CA) | 0 | ? | |
| 1921 | L | Ludington Legion (MI) | 0 | Ferris St. (MI) | 75 | Big Rapids, MI | |
| 1921 | L | Ludlow HS (PA) | 0 | Kane HS (PA) | 39 | ? | |
| 1921 | L | Luther (IA) | 3 | Campion College (WI) | 6 | Decorah, IA | |
| 1921 | L | Luther (IA) | 7 | Loras (IA) | 20 | Dubuque, IA | |
| 1921 | L | Luther (IA) | 0 | Saint Olaf (MN) | 10 | ? | |
| 1921 | W | Luther (IA) | 35 | Trinity (IA) | 0 | ? | |
| 1921 | L | Luther (IA) | 0 | Dubuque (IA) | 20 | Dubuque, IA | |
| 1921 | W | Luther (IA) | 33 | Upper Iowa | 7 | Decorah, IA | |
| 1921 | W | Luverne HS (AL) | 30 | Troy (AL) | 0 | Luverne, AL | |
| 1921 | W | Luverne HS (AL) | 34 | Troy (AL) | 0 | Troy, AL | |
| 1921 | L | Luverne HS (MN) | 0 | Pipestone HS (MN) | 23 | ? | |
| 1921 | L | Luverne HS (MN) | 0 | Windom HS (MN) | 25 | ? | |
| 1921 | W | Lycoming (PA) | 28 | Bloomsburg (PA) | 0 | Bloomsburg, PA | |
| 1921 | L | Lycoming (PA) | 0 | Wyoming Seminary (PA) | 21 | ? | |
| 1921 | L | Lykens HS (PA) | 7 | Harrisburg Academy (PA) | 14 | ? | |
| 1921 | L | Lykens HS (PA) | 7 | Minersville HS (PA) | 27 | ? | |
| 1921 | L | Lynbrook HS (NY) | 0 | Freeport HS (NY) | 12 | ? | |
| 1921 | T | Lynbrook HS (NY) | 7 | Jamaica HS (NY) | 7 | ? | |
| 1921 | L | Lynbrook HS (NY) | 0 | Port Washington HS (NY) | 1 | ? | |
| 1921 | L | Lynchburg (VA) | 6 | Emory & Henry (VA) | 21 | Emory, VA | |
| 1921 | W | Lynchburg (VA) | 32 | Guilford (NC) | 14 | Lynchburg, VA | |
| 1921 | L | Lynchburg (VA) | 0 | Howard (DC) | 19 | ? | |
| 1921 | W | Lynchburg (VA) | 8 | Roanoke (VA) | 7 | Lynchburg, VA | |
| 1921 | L | Lynchburg (VA) | 13 | Duke (NC) | 14 | Durham, NC | |
| 1921 | W | Lynchburg (VA) | 15 | Elon (NC) | 7 | Lynchburg, VA | |
| 1921 | T | Lynchburg (VA) | 7 | Hampden-Sydney (VA) | 7 | Lynchburg, VA | |
| 1921 | L | Lynchburg HS (VA) | 0 | Roanoke HS (VA) | 3 | ? | |
| 1921 | W | Lynchburg HS (VA) | 9 | Salem HS (VA) | 0 | ? | |
| 1921 | W | Lynchburg HS (VA) | 6 | Virginia Episcopal School (VA) | 0 | ? | |
| 1921 | L | Lynchburg JV (VA) | 0 | Chatham Training School (VA) | 39 | ? | |
| 1921 | W | Lynn Classical HS (MA) | 21 | Gloucester HS (MA) | 7 | ? | |
| 1921 | L | Lynn Classical HS (MA) | 0 | Haverhill HS (MA) | 7 | ? | |
| 1921 | W | Lynn Classical HS (MA) | 7 | Marblehead HS (MA) | 0 | ? | |
| 1921 | L | Lynn Classical HS (MA) | 0 | Peabody HS (MA) | 21 | ? | |
| 1921 | W | Lynn Classical HS (MA) | 7 | Revere HS (MA) | 0 | ? | |
| 1921 | W | Lynn Classical HS (MA) | 28 | Thayer Academy (MA) | 0 | ? | |
| 1921 | L | Lynn English HS (MA) | 6 | Marblehead HS (MA) | 27 | ? | |
| 1921 | L | Lynn English HS (MA) | 0 | Peabody HS (MA) | 21 | ? | |
| 1921 | L | Lynn English HS (MA) | 0 | Revere HS (MA) | 6 | ? | |
| 1921 | L | Lyon College (AR) | 7 | Arkansas St. | 14 | Jonesboro, AR | |
| 1921 | L | Lyon College (AR) | 0 | Hendrix (AR) | 13 | Batesville, AR | |
| 1921 | L | Lyon College (AR) | 0 | Tennessee Medical College | 19 | ? | |
| 1921 | L | Lyon College (AR) | 7 | Henderson St. (AR) | 29 | Arkadelphia, AR | |
| 1921 | L | Lyon College (AR) | 0 | Union (TN) | 28 | Jackson, TN | |
| 1921 | L | Macalester (MN) | 0 | Hamline (MN) | 21 | Saint Paul, MN | |
| 1921 | L | Macalester (MN) | 6 | Saint Olaf (MN) | 7 | Northfield, MN | |
| 1921 | T | Macalester (MN) | 0 | Wisconsin-Stout | 0 | Saint Paul, MN | |
| 1921 | W | Macalester (MN) | 34 | Gustavus Adolphus (MN) | 0 | Saint Paul, MN | |
| 1921 | W | Macalester (MN) | 14 | Saint John's (MN) | 0 | Saint Paul, MN | |
| 1921 | L | MacKenzie School (NY) | 0 | Ramsey HS (NJ) | 13 | ? | |
| 1921 | L | Macomb HS (IL) | 7 | Elgin HS (IL) | 35 | ? | |
| 1921 | W | Macomb HS (IL) | 13 | Quincy HS (IL) | 7 | ? | |
| 1921 | L | Madera HS (CA) | 0 | Fresno HS (CA) | 54 | ? | |
| 1921 | L | Madera HS (CA) | 0 | Selma HS (CA) | 75 | ? | |
| 1921 | L | Madison HS (GA) | 0 | Athens HS (GA) | 55 | ? | |
| 1921 | L | Madison HS (WI) | 13 | Kenosha HS (WI) | 14 | ? | |
| 1921 | T | Madisonville HS (KY) | 0 | Morganfield HS (KY) | 0 | ? | |
| 1921 | L | Madisonville HS (KY) | 6 | Morganfield HS (KY) | 7 | ? | |
| 1921 | T | Madisonville HS (KY) | 0 | Sturgis HS (KY) | 0 | ? | |
| 1921 | L | Magnard HS | 0 | Hudson HS (MA) | 7 | ? | |
| 1921 | L | Mahanoy City HS (PA) | 0 | Mount Carmel HS (PA) | 5 | ? | |
| 1921 | T | Maine | 7 | Bates (ME) | 7 | Lewiston, ME | |
| 1921 | L | Maine | 0 | Colby (ME) | 3 | Waterville, ME | |
| 1921 | L | Maine | 14 | Fordham (NY) | 25 | New York, NY | |
| 1921 | W | Maine | 7 | Rhode Island | 3 | Orono, ME | |
| 1921 | L | Maine | 0 | Norwich (VT) | 14 | Orono, ME | |
| 1921 | L | Maine | 7 | Bowdoin (ME) | 14 | Orono, ME | |
| 1921 | W | Maine | 34 | Massachusetts-Lowell | 0 | Orono, ME | |
| 1921 | L | Maine | 7 | Stevens Tech (NJ) | 34 | Hoboken, NJ | |
| 1921 | W | Malden HS (MA) | 10 | Boston College HS (MA) | 0 | ? | |
| 1921 | W | Malden HS (MA) | 7 | Brookline HS (MA) | 0 | ? | |
| 1921 | W | Malden HS (MA) | 14 | Cambridge Latin & HS (MA) | 6 | ? | |
| 1921 | W | Malden HS (MA) | 14 | Everett HS (MA) | 7 | ? | |
| 1921 | T | Malden HS (MA) | 7 | Haverhill HS (MA) | 7 | ? | |
| 1921 | W | Malden HS (MA) | 10 | Medford HS (MA) | 7 | ? | |
| 1921 | L | Malden HS (MA) | 7 | Newton North HS (MA) | 13 | ? | |
| 1921 | W | Malden HS (MA) | 10 | Rindge Tech (MA) | 0 | ? | |
| 1921 | W | Malden HS (MA) | 14 | Saugus HS (MA) | 6 | ? | |
| 1921 | W | Malden HS (MA) | 17 | Somerville HS (MA) | 7 | ? | |
| 1921 | L | Malden HS (MA) | 0 | Toledo Waite HS (OH) | 13 | ? | |
| 1921 | W | Malden HS (MA) | 32 | Woburn HS (MA) | 6 | ? | |
| 1921 | L | Malone HS (NY) | 12 | Massena HS (NY) | 35 | ? | |
| 1921 | W | Mamaroneck HS (NY) | 14 | City College of New York Freshmen | 6 | ? | |
| 1921 | L | Mamaroneck HS (NY) | 0 | Flushing HS (NY) | 21 | ? | |
| 1921 | L | Mamaroneck HS (NY) | 0 | Hoboken Stevens Prep HS (NJ) | 1 | ? | |
| 1921 | L | Mamaroneck HS (NY) | 6 | Mount Vernon HS (NY) | 41 | ? | |
| 1921 | L | Mamaroneck HS (NY) | 0 | New Rochelle HS (NY) | 14 | ? | |
| 1921 | L | Mamaroneck HS (NY) | 0 | Port Chester HS (NY) | 20 | ? | |
| 1921 | W | Mamaroneck HS (NY) | 21 | White Plains HS (NY) | 0 | ? | |
| 1921 | L | Mamaroneck HS (NY) | 0 | Yonkers HS (NY) | 14 | ? | |
| 1921 | L | Manchester HS (IA) | 0 | Cedar Rapids HS (IA) | 85 | ? | |
| 1921 | L | Manchester HS (MA) | 0 | Fitchburg HS (MA) | 14 | ? | |
| 1921 | L | Manchester HS (MA) | 14 | Haverhill HS (MA) | 28 | ? | |
| 1921 | W | Manchester HS (NH) | 23 | Brewster Academy (NH) | 0 | ? | |
| 1921 | W | Manchester HS (NH) | 14 | Concord HS (NH) | 0 | ? | |
| 1921 | L | Manchester HS (NH) | 0 | Fitchburg HS (MA) | 14 | ? | |
| 1921 | L | Manchester HS (NH) | 14 | Haverhill HS (MA) | 28 | ? | |
| 1921 | W | Manchester HS (NH) | 57 | Keene HS (NH) | 7 | ? | |
| 1921 | W | Manchester HS (NH) | 27 | Lawrence HS (MA) | 7 | ? | |
| 1921 | W | Manchester HS (NH) | 14 | Lowell HS (MA) | 0 | ? | |
| 1921 | W | Manchester HS (NH) | 28 | Nashua HS (NH) | 0 | ? | |
| 1921 | W | Manchester HS (NH) | 26 | Pinkerton Academy | 0 | ? | |
| 1921 | W | Manchester HS (NH) | 13 | Portland HS (ME) | 0 | ? | |
| 1921 | W | Manchester HS (NH) | 26 | Worcester South HS (MA) | 0 | ? | |
| 1921 | W | Mankato HS (MN) | 45 | Blue Earth HS (MN) | 0 | ? | |
| 1921 | W | Mankato HS (MN) | 65 | New Ulm HS (MN) | 0 | ? | |
| 1921 | W | Mankato HS (MN) | 53 | Northfield HS (MN) | 0 | ? | |
| 1921 | W | Mankato HS (MN) | 40 | Owatonna HS (MN) | 0 | ? | |
| 1921 | W | Mankato HS (MN) | 21 | Rochester HS (MN) | 7 | ? | |
| 1921 | W | Mankato HS (MN) | 3 | Saint Peter HS (MN) | 0 | ? | |
| 1921 | T | Mankato HS (MN) | 0 | Sleepy Eye HS (MN) | 0 | ? | |
| 1921 | W | Mankato HS (MN) | 7 | Waseca HS (MN) | 0 | ? | |
| 1921 | W | Mankato HS (MN) | 48 | Wells HS (MN) | 0 | ? | |
| 1921 | W | Mannington HS (WV) | 34 | Belington HS (WV) | 0 | ? | |
| 1921 | W | Mannington HS (WV) | 20 | Clarksburg Victory HS (WV) | 0 | ? | |
| 1921 | L | Mannington HS (WV) | 0 | Elkins HS (WV) | 32 | ? | |
| 1921 | W | Mannington HS (WV) | 27 | Fairmont East Side HS (WV) | 0 | ? | |
| 1921 | L | Mannington HS (WV) | 0 | Fairmont HS (WV) | 7 | ? | |
| 1921 | T | Mannington HS (WV) | 7 | Grafton HS (WV) | 7 | ? | |
| 1921 | W | Mannington HS (WV) | 42 | Shinnston HS (WV) | 0 | ? | |
| 1921 | W | Mannington HS (WV) | 42 | Triadelphia HS (WV) | 0 | ? | |
| 1921 | W | Mannington HS (WV) | 44 | West Union HS (WV) | 0 | ? | |
| 1921 | L | Mannington HS (WV) | 0 | Weston HS (WV) | 7 | ? | |
| 1921 | W | Mansfield (PA) | 14 | Alfred (NY) | 13 | Mansfield, PA | Disputed Game |
| 1921 | W | Mansfield (PA) | 20 | Bucknell B Team (PA) | 7 | ? | |
| 1921 | L | Mansfield (PA) | 0 | Penn St. Freshmen | 49 | State College, PA | |
| 1921 | W | Mansfield (PA) | 27 | Saint John's Military Academy (NY) | 0 | Manlius, NY | |
| 1921 | W | Mansfield (PA) | 120 | Ulysses HS (PA) | 0 | ? | |
| 1921 | W | Mansfield (PA) | 40 | East Stroudsburg (PA) | 0 | Mansfield, PA | Smythe Field |
| 1921 | W | Mansfield (PA) | 85 | Sayre Mechanical School (PA) | 0 | Mansfield, PA | |
| 1921 | W | Mansfield HS (MA) | 7 | Dedham HS (MA) | 6 | ? | |
| 1921 | L | Mansfield HS (MA) | 0 | Fall River Durfee HS (MA) | 28 | ? | |
| 1921 | W | Mansfield HS (MA) | 13 | Fall River Durfee HS (MA) | 0 | ? | |
| 1921 | L | Mansfield HS (MA) | 7 | Norwood HS (MA) | 28 | ? | |
| 1921 | L | Mansfield HS (OH) | 6 | Sandusky HS (OH) | 16 | ? | |
| 1921 | W | Mansfield HS (PA) | 13 | Athens HS (PA) | 0 | ? | |
| 1921 | L | Mansfield JV (PA) | 0 | Endicott Union HS (NY) | 7 | ? | |
| 1921 | L | Maplewood HS (MO) | 0 | Principia Academy (MO) | 10 | ? | |
| 1921 | L | Maplewood HS (MO) | 0 | Webster Groves HS (MO) | 7 | ? | |
| 1921 | W | Marblehead HS (MA) | 13 | Beverly HS (MA) | 7 | ? | |
| 1921 | W | Marblehead HS (MA) | 74 | Chelsea HS (MA) | 0 | ? | |
| 1921 | W | Marblehead HS (MA) | 23 | Danvers HS (MA) | 0 | ? | |
| 1921 | W | Marblehead HS (MA) | 13 | Gloucester HS (MA) | 0 | ? | |
| 1921 | L | Marblehead HS (MA) | 0 | Lynn Classical HS (MA) | 7 | ? | |
| 1921 | W | Marblehead HS (MA) | 27 | Lynn English HS (MA) | 6 | ? | |
| 1921 | L | Marblehead HS (MA) | 7 | Peabody HS (MA) | 14 | ? | |
| 1921 | W | Marblehead HS (MA) | 20 | Quincy HS (MA) | 0 | ? | |
| 1921 | L | Marblehead HS (MA) | 0 | Revere HS (MA) | 14 | ? | |
| 1921 | W | Marblehead HS (MA) | 10 | Salem HS (MA) | 7 | ? | |
| 1921 | W | Marblehead HS (MA) | 21 | Swampscott HS (MA) | 0 | ? | |
| 1921 | W | Marblehead HS (MA) | 27 | Winthrop HS (MA) | 6 | ? | |
| 1921 | L | Mare Island Marines (CA) | 0 | California-Davis | 7 | ? | |
| 1921 | W | Mare Island Marines (CA) | 39 | Pacific (CA) | 14 | ? | |
| 1921 | L | Mare Island Marines (CA) | 6 | Saint Mary's (CA) | 46 | Vallejo, CA | |
| 1921 | L | Mare Island Marines (CA) | 0 | Santa Clara (CA) | 14 | Santa Clara, CA | |
| 1921 | W | Marietta (OH) | 48 | Davis & Elkins (WV) | 0 | ? | |
| 1921 | L | Marietta (OH) | 2 | Grove City (PA) | 27 | Grove City, PA | |
| 1921 | T | Marietta (OH) | 0 | Marshall (WV) | 0 | ? | |
| 1921 | T | Marietta (OH) | 0 | Ohio | 0 | Athens, OH | |
| 1921 | W | Marietta (OH) | 22 | Thiel (PA) | 0 | Marietta, OH | |
| 1921 | W | Marietta (OH) | 20 | West Virginia Wesleyan | 0 | Marietta, OH | |
| 1921 | L | Marietta (OH) | 7 | Bethany (WV) | 28 | Marietta, OH | |
| 1921 | L | Marietta (OH) | 0 | Boston College (MA) | 14 | Chestnut Hill, MA | |
| 1921 | T | Marietta (OH) | 7 | Duquesne (PA) | 7 | New Wilmington, PA | |
| 1921 | L | Marietta (OH) | 0 | Detroit (MI) | 34 | Detroit, MI | |
| 1921 | L | Marietta HS (OH) | 0 | Huntington HS (WV) | 20 | ? | |
| 1921 | L | Marietta HS (OH) | 6 | Parkersburg HS (WV) | 35 | ? | |
| 1921 | L | Marietta HS (OH) | 0 | Parkersburg HS (WV) | 7 | ? | |
| 1921 | W | Marietta JV (OH) | 14 | Sistersville HS (WV) | 6 | ? | |
| 1921 | L | Marine Barracks (NH) | 0 | New London Submarine Base (CT) | 85 | ? | |
| 1921 | W | Marinette HS (WI) | 14 | Superior HS (WI) | 0 | ? | |
| 1921 | L | Marion HS (IL) | 0 | Murphysboro HS (IL) | 41 | ? | |
| 1921 | L | Marion HS (KS) | 0 | Sapulpa HS (OK) | 10 | ? | |
| 1921 | L | Marion Military Institute (AL) | 3 | Auburn (AL) | 49 | ? | |
| 1921 | L | Marion Military Institute (AL) | 0 | Auburn JV (AL) | 49 | ? | Auburn JV in question |
| 1921 | L | Marion Military Institute (AL) | 0 | Birmingham-Southern (AL) | 19 | Birmingham, AL | |
| 1921 | T | Marion Military Institute (AL) | 0 | Jacksonville St. (AL) | 0 | ? | |
| 1921 | L | Marion Military Institute (AL) | 0 | Spring Hill (AL) | 41 | Mobile, AL | |
| 1921 | L | Marion Military Institute (AL) | 0 | Samford (AL) | 21 | Montgomery, AL | |
| 1921 | L | Marion Military Institute (AL) | 0 | Alabama | 55 | Tuscaloosa, AL | |
| 1921 | L | Marksville HS (LA) | 0 | Baton Rouge HS (LA) | 54 | ? | |
| 1921 | L | Marlboro HS (VT) | 0 | Clinton HS (MA) | 21 | ? | |
| 1921 | T | Marlboro HS (VT) | 0 | Framingham HS (MA) | 0 | ? | |
| 1921 | W | Marlboro HS (VT) | 21 | Hudson HS (MA) | 7 | ? | |
| 1921 | L | Marlboro HS (VT) | 7 | Natick HS (MA) | 46 | ? | |
| 1921 | T | Marquand School (NY) | 0 | Brooklyn Commercial HS (NY) | 0 | ? | |
| 1921 | L | Marquand School (NY) | 0 | Brooklyn Poly Prep School (NY) | 52 | ? | |
| 1921 | W | Marquand School (NY) | 26 | Chelsea HS (MA) | 0 | ? | |
| 1921 | W | Marquand School (NY) | 27 | Glen Cove HS (NY) | 7 | ? | |
| 1921 | T | Marquand School (NY) | 0 | Horace Mann School (NY) | 0 | ? | |
| 1921 | L | Marquand School (NY) | 6 | Clason Military Academy (NY) | 7 | ? | |
| 1921 | W | Marquand School (NY) | 29 | Adelphi Academy (NY) | 0 | Brooklyn, NY | Ozone Park |
| 1921 | W | Marquette (WI) | 55 | Campion College (WI) | 0 | Milwaukee, WI | |
| 1921 | L | Marquette (WI) | 0 | Creighton (NE) | 3 | Omaha, NE | |
| 1921 | W | Marquette (WI) | 7 | Michigan St. | 0 | Milwaukee, WI | |
| 1921 | L | Marquette (WI) | 7 | Notre Dame (IN) | 21 | Milwaukee, WI | |
| 1921 | W | Marquette (WI) | 7 | Wabash (IN) | 0 | Milwaukee, WI | |
| 1921 | W | Marquette (WI) | 14 | Carroll (WI) | 0 | Milwaukee, WI | |
| 1921 | W | Marquette (WI) | 41 | Haskell Indian Nations (KS) | 2 | Milwaukee, WI | |
| 1921 | T | Marquette (WI) | 0 | Ripon (WI) | 0 | Milwaukee, WI | |
| 1921 | W | Marquette (WI) | 7 | North Dakota | 3 | Milwaukee, WI | |
| 1921 | W | Marquette Academy (WI) | 39 | Elgin Academy (IL) | 0 | ? | |
| 1921 | W | Marquette Academy (WI) | 27 | Green Bay West HS (WI) | 6 | ? | |
| 1921 | L | Marquette Academy (WI) | 0 | Lake Forest Academy (IL) | 21 | ? | |
| 1921 | W | Marquette Academy (WI) | 7 | Marquette Academy Alumni (WI) | 0 | ? | |
| 1921 | T | Marquette Academy (WI) | 0 | Wisconsin-Whitewater | 0 | ? | |
| 1921 | W | Marquette Academy (WI) | 39 | Saint Norbert (WI) | 0 | Milwaukee, WI | |
| 1921 | W | Marquette Academy (WI) | 42 | Campion College (WI) | 0 | Praire Du Chien, WI | |
| 1921 | L | Marquette Academy Alumni (WI) | 0 | Marquette Academy (WI) | 7 | ? | |
| 1921 | L | Mars Hill JC (NC) | 7 | Asheville HS (NC) | 19 | ? | |
| 1921 | L | Mars Hill JC (NC) | 0 | Bingham Military School (NC) | 55 | ? | |
| 1921 | L | Mars Hill JC (NC) | 0 | Weaver College (NC) | 21 | ? | |
| 1921 | L | Mars Hill JC (NC) | 9 | Weaver College (NC) | 13 | ? | |
| 1921 | W | Marshall (WV) | 14 | Louisville (KY) | 0 | Huntington, WV | |
| 1921 | T | Marshall (WV) | 0 | Marietta (OH) | 0 | ? | |
| 1921 | W | Marshall (WV) | 33 | Rio Grande (OH) | 3 | ? | |
| 1921 | W | Marshall (WV) | 6 | Salem College (WV) | 0 | ? | |
| 1921 | W | Marshall (WV) | 13 | Transylvania (KY) | 0 | Lexington, KY | |
| 1921 | L | Marshall (WV) | 0 | West Virginia Tech | 7 | ? | |
| 1921 | W | Marshall (WV) | 13 | Broaddus College (WV) | 3 | ? | |
| 1921 | L | Marshall (WV) | 0 | Kentucky | 28 | Lexington, KY | |
| 1921 | W | Marshall (WV) | 7 | Georgetown (KY) | 0 | Georgetown, KY | |
| 1921 | L | Marshall All-Stars (TX) | 0 | College of Marshall (TX) | 13 | ? | |
| 1921 | L | Marshall HS (IL) | 6 | Chicago Bowen HS (IL) | 7 | ? | |
| 1921 | W | Marshall HS (MI) | 31 | Adrian HS (MI) | 0 | ? | |
| 1921 | T | Marshall HS (MI) | 6 | Albion HS (MI) | 6 | ? | |
| 1921 | L | Marshall HS (MI) | 0 | Ann Arbor HS (MI) | 20 | ? | |
| 1921 | W | Marshall HS (MI) | 100 | Charlotte HS (MI) | 0 | ? | |
| 1921 | W | Marshall HS (MI) | 33 | Coldwater HS (MI) | 0 | ? | |
| 1921 | W | Marshall HS (MI) | 42 | East Lansing HS (MI) | 0 | ? | |
| 1921 | W | Marshall HS (MI) | 28 | Hastings HS (MI) | 0 | ? | |
| 1921 | L | Marshall HS (MI) | 0 | Hillsdale HS (MI) | 14 | ? | |
| 1921 | W | Marshall HS (MI) | 41 | Homer HS (MI) | 0 | ? | |
| 1921 | L | Marshall HS (MI) | 3 | Kalamazoo HS (MI) | 13 | ? | |
| 1921 | L | Marshall HS (MN) | 0 | Montevideo HS (MN) | 53 | ? | |
| 1921 | W | Marshall HS (MN) | 21 | Pipestone HS (MN) | 6 | ? | |
| 1921 | T | Marshall HS (MN) | 7 | Windom HS (MN) | 7 | ? | |
| 1921 | L | Marshall JV (WV) | 0 | Ceredo-Kenova HS (WV) | 1 | ? | |
| 1921 | T | Marshalltown HS (IA) | 0 | Waterloo East HS (IA) | 0 | ? | |
| 1921 | L | Marston's University School (MD) | 0 | Baltimore Friends School (MD) | 79 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 26 | Alliance HS (OH) | 7 | ? | |
| 1921 | L | Martins Ferry HS (OH) | 0 | Bellaire HS (OH) | 7 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 7 | Cambridge HS (OH) | 2 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 25 | Columbus East HS (OH) | 0 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 41 | Coshocton HS (OH) | 0 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 40 | Crafton HS (PA) | 7 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 26 | Fostoria HS (OH) | 20 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 20 | Linsly Military Institute (WV) | 0 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 34 | Massillon HS (OH) | 12 | ? | |
| 1921 | W | Martins Ferry HS (OH) | 6 | Mingo HS (OH) | 0 | ? | |
| 1921 | L | Martinsburg HS (WV) | 0 | Shenandoah Military Academy (VA) | 33 | ? | |
| 1921 | L | Martinsburg HS (WV) | 6 | Shepherd (WV) | 18 | Shepherdstown, WV | |
| 1921 | L | Martinsville HS (VA) | 2 | Roanoke HS (VA) | 107 | ? | |
| 1921 | L | Marvin College (MO) | 6 | Charleston HS (MO) | 17 | ? | |
| 1921 | L | Marvin College (MO) | 6 | Charleston HS (MO) | 26 | ? | |
| 1921 | W | Marvin College (MO) | 2 | Farmington All-Stars (MO) | 0 | ? | |
| 1921 | L | Marvin College (MO) | 0 | Jackson HS (MO) | 13 | ? | |
| 1921 | W | Marvin College (MO) | 1 | Jackson HS (MO) | 0 | ? | Jackson HS Forfeits |
| 1921 | W | Marvin College (MO) | 53 | Perryville HS (MO) | 0 | ? | |
| 1921 | W | Marvin College (MO) | 1 | Perryville HS (MO) | 0 | ? | Perryville HS Forfetis |
| 1921 | W | Marvin College (MO) | 34 | Saint Vincent's Academy | 0 | ? | |
| 1921 | W | Marvin College (MO) | 6 | Will Mayfield College (MO) | 0 | ? | |
| 1921 | L | Maryland | 0 | Carnegie Mellon (PA) | 21 | Pittsburgh, PA | |
| 1921 | L | Maryland | 7 | North Carolina | 16 | Baltimore, MD | |
| 1921 | T | Maryland | 6 | North Carolina St. | 6 | Baltimore, MD | |
| 1921 | L | Maryland | 3 | Saint John's (MD) | 7 | College Park, MD | |
| 1921 | W | Maryland | 10 | Virginia Tech | 7 | Washington, DC | |
| 1921 | W | Maryland | 3 | Rutgers (NJ) | 0 | New Brunswick, NJ | |
| 1921 | L | Maryland | 0 | Yale (CT) | 28 | New Haven, CT | |
| 1921 | L | Maryland | 0 | Syracuse (NY) | 42 | Syracuse, NY | |
| 1921 | W | Maryland | 16 | Catholic (DC) | 0 | Washington, DC | |
| 1921 | W | Maryland Freshmen | 13 | Army & Navy Prep School (DC) | 9 | ? | |
| 1921 | L | Maryland Freshmen | 0 | Washington Central HS (DC) | 10 | ? | |
| 1921 | L | Maryland Freshmen | 0 | Washington Technical HS (DC) | 14 | ? | |
| 1921 | L | Marysville HS (CA) | 0 | Cal St.-Chico | 46 | ? | |
| 1921 | L | Marysville HS (CA) | 14 | Glenn County HS (CA) | 41 | ? | |
| 1921 | L | Marysville HS (OH) | 7 | London HS (OH) | 26 | ? | |
| 1921 | W | Marysville HS (OH) | 28 | Richmond HS (OH) | 6 | ? | |
| 1921 | L | Marysville HS (OH) | 18 | Richmond HS (OH) | 20 | ? | |
| 1921 | L | Marysville HS (OH) | 0 | Springfield HS (OH) | 27 | ? | |
| 1921 | W | Marysville HS (WA) | 119 | Granite Falls HS (WA) | 0 | ? | |
| 1921 | W | Maryville (TN) | 34 | Emory & Henry (VA) | 7 | Maryville, TN | |
| 1921 | W | Maryville (TN) | 27 | Knoxville Central HS (TN) | 0 | Maryville, TN | |
| 1921 | W | Maryville (TN) | 54 | Milligan (TN) | 0 | Maryville, TN | |
| 1921 | W | Maryville (TN) | 16 | Roanoke (VA) | 0 | Bluefield, VA | |
| 1921 | W | Maryville (TN) | 34 | Tennessee-Chattanooga | 0 | Chattanooga, TN | |
| 1921 | L | Maryville (TN) | 0 | Tennessee | 7 | Knoxville, TN | |
| 1921 | W | Maryville (TN) | 47 | Cumberland (TN) | 7 | Maryville, TN | |
| 1921 | T | Maryville (TN) | 7 | Cumberland (KY) | 7 | Williamsburg, KY | |
| 1921 | W | Maryville (TN) | 5 | Carson-Newman (TN) | 0 | Jefferson City, TN | |
| 1921 | W | Mason City HS (IA) | 21 | Osage HS (IA) | 0 | ? | |
| 1921 | L | Massachusetts | 0 | Amherst (MA) | 13 | Amherst, MA | |
| 1921 | W | Massachusetts | 14 | Tufts (MA) | 0 | Amherst, MA | |
| 1921 | L | Massachusetts | 7 | Vermont | 14 | Amherst, MA | |
| 1921 | W | Massachusetts | 35 | Worcester Tech (MA) | 0 | Worcester, MA | |
| 1921 | W | Massachusetts | 13 | Connecticut | 0 | Storrs, CT | |
| 1921 | L | Massachusetts | 2 | Rhode Island | 7 | Kingston, RI | |
| 1921 | T | Massachusetts | 0 | Bates (ME) | 0 | Lewiston, ME | |
| 1921 | L | Massachusetts | 7 | New Hampshire | 56 | Durham, NH | |
| 1921 | L | Massachusetts-Dartmouth | 0 | Norwood HS (MA) | 13 | ? | |
| 1921 | T | Massachusetts-Lowell | 7 | Connecticut | 7 | Lowell, MA | |
| 1921 | L | Massachusetts-Lowell | 7 | New Hampshire | 41 | Dover, NH | |
| 1921 | W | Massachusetts-Lowell | 3 | Worcester Tech (MA) | 0 | Lowell, MA | |
| 1921 | L | Massachusetts-Lowell | 0 | Maine | 34 | Orono, ME | |
| 1921 | L | Massanutten Military Academy (VA) | 7 | Fishburne Military School (VA) | 14 | ? | |
| 1921 | L | Massee Country | 0 | Barnard School (NY) | 53 | ? | |
| 1921 | W | Massena HS (NY) | 34 | Canton HS (NY) | 6 | ? | |
| 1921 | W | Massena HS (NY) | 66 | Gouveneur | 0 | ? | |
| 1921 | W | Massena HS (NY) | 35 | Malone HS (NY) | 12 | ? | |
| 1921 | T | Massena HS (NY) | 13 | Ogdensburg HS (NY) | 13 | ? | |
| 1921 | L | Massena HS (NY) | 0 | Potsdam HS (NY) | 7 | ? | |
| 1921 | W | Massena HS (NY) | 34 | Potsdam HS (NY) | 6 | ? | |
| 1921 | L | Massena HS (NY) | 13 | Saint John's Military Academy (NY) | 28 | ? | |
| 1921 | W | Massena HS (NY) | 19 | Saint Mary's Academy | 0 | ? | |
| 1921 | T | Massey Military Academy (TN) | 0 | Nashville Hume-Fogg HS (TN) | 0 | ? | |
| 1921 | L | Massey School | 7 | Peekskill Military Academy (NY) | 68 | ? | |
| 1921 | L | Massillon HS (OH) | 0 | Alliance HS (OH) | 25 | ? | |
| 1921 | W | Massillon HS (OH) | 13 | Canton McKinley HS (OH) | 12 | ? | |
| 1921 | L | Massillon HS (OH) | 0 | Dayton Steele HS (OH) | 68 | ? | |
| 1921 | L | Massillon HS (OH) | 12 | Martins Ferry HS (OH) | 34 | ? | |
| 1921 | L | Massillon HS (OH) | 0 | Warren HS (OH) | 13 | ? | |
| 1921 | W | Massillon HS (OH) | 17 | Youngstown South HS (OH) | 6 | ? | |
| 1921 | L | Maxwell HS (NE) | 0 | Nebraska School of Agriculture | 93 | ? | |
| 1921 | L | Mayfield HS (KY) | 0 | Morganfield HS (KY) | 14 | ? | |
| 1921 | W | Mayville HS (WI) | 20 | Watertown HS (WI) | 0 | ? | |
| 1921 | L | Mayville HS (WI) | 0 | Wayland Academy (WI) | 7 | ? | |
| 1921 | L | McAlester HS (OK) | 0 | Oklahoma City HS (OK) | 21 | ? | |
| 1921 | L | McBurney School | 0 | Clason Military Academy (NY) | 38 | Bronx, NY | |
| 1921 | W | McCallie School (TN) | 12 | Baylor Military Academy (TN) | 6 | ? | |
| 1921 | T | McComb County HS (MS) | 0 | Jackson HS (MS) | 0 | ? | |
| 1921 | L | McComb HS (OH) | 20 | Mount Cory HS (OH) | 21 | ? | |
| 1921 | L | McCook HS (NE) | 14 | Cambridge HS (NE) | 26 | ? | |
| 1921 | W | McCook HS (NE) | 62 | Holdrege HS (NE) | 6 | ? | |
| 1921 | L | McCook HS (NE) | 0 | Nebraska School of Agriculture | 10 | ? | |
| 1921 | L | McCook HS (NE) | 0 | North Platte HS (NE) | 28 | ? | |
| 1921 | L | McDaniel College (MD) | 7 | Albright (PA) | 20 | Westminster, MD | |
| 1921 | L | McDaniel College (MD) | 0 | Johns Hopkins (MD) | 44 | Baltimore, MD | |
| 1921 | L | McDaniel College (MD) | 0 | Mount Saint Mary's (MD) | 21 | Westminster, MD | |
| 1921 | T | McDaniel College (MD) | 0 | Washington (MD) | 0 | Westminster, MD | |
| 1921 | L | McDaniel College (MD) | 0 | Saint John's (MD) | 29 | Annapolis, MD | |
| 1921 | L | McDaniel College (MD) | 6 | Delaware | 48 | Newark, DE | |
| 1921 | L | McDaniel College (MD) | 7 | George Washington (DC) | 20 | Washington, DC | |
| 1921 | W | McDaniel College (MD) | 14 | Drexel Institute (PA) | 0 | Westminster, MD | |
| 1921 | W | McDonogh School (MD) | 21 | Baltimore Friends School (MD) | 14 | ? | |
| 1921 | L | McDonogh School (MD) | 0 | Gilman Country School (MD) | 45 | ? | |
| 1921 | L | McDonogh School (MD) | 0 | Mount Saint Joseph's College (MD) | 17 | ? | |
| 1921 | L | McGill (QC) | 0 | Syracuse (NY) | 13 | Montreal, QC (Canada) | |
| 1921 | L | McGuffey Prep (OH) | 0 | Miami Military Institute (OH) | 47 | ? | |
| 1921 | L | McGuire's University School | 0 | Virginia Episcopal School (VA) | 48 | ? | |
| 1921 | W | McKees Rocks HS (PA) | 6 | North Braddock HS (PA) | 0 | ? | |
| 1921 | W | McKeesport HS (PA) | 14 | Duquesne HS (PA) | 0 | ? | |
| 1921 | L | McKeesport HS (PA) | 0 | New Castle HS (PA) | 12 | ? | |
| 1921 | W | McKendree (IL) | 46 | Blackburn (IL) | 0 | ? | |
| 1921 | W | McKendree (IL) | 94 | Country Day School (MO) | 0 | ? | |
| 1921 | W | McKendree (IL) | 7 | Shurtleff (IL) | 0 | Lebanon, IL | |
| 1921 | W | McKendree (IL) | 20 | Southern Illinois | 0 | Lebanon, IL | |
| 1921 | L | McKendree (IL) | 0 | Southern Illinois | 7 | Carbondale, IL | |
| 1921 | W | McKinley Manual Training HS | 60 | Army & Navy Prep School (DC) | 0 | ? | |
| 1921 | L | McLean HS (IL) | 9 | Lincoln HS (IL) | 27 | ? | |
| 1921 | L | McPherson (KS) | 0 | Baker (KS) | 3 | Baldwin City, KS | |
| 1921 | W | McPherson (KS) | 35 | Chilocco Indian School (OK) | 0 | McPherson, KS | |
| 1921 | L | McPherson (KS) | 0 | Fort Hays St. (KS) | 32 | Hays, KS | |
| 1921 | W | McPherson (KS) | 75 | Hutchinson KSIR | 0 | McPherson, KS | |
| 1921 | W | McPherson (KS) | 19 | Kansas Wesleyan | 0 | McPherson, KS | |
| 1921 | L | McPherson (KS) | 0 | Ottawa (KS) | 7 | ? | |
| 1921 | W | McPherson (KS) | 21 | Saint John's American Legion (KS) | 7 | McPherson, KS | |
| 1921 | L | McPherson (KS) | 0 | Wichita St. (KS) | 24 | McPherson, KS | |
| 1921 | W | McPherson (KS) | 13 | Sterling (KS) | 0 | McPherson, KS | |
| 1921 | L | McPherson (KS) | 14 | Saint Mary's (KS) | 17 | Saint Mary's, KS | |
| 1921 | L | McPherson (KS) | 6 | Bethany (KS) | 7 | Lindsborg, KS | |
| 1921 | L | Mechanics Arts HS | 0 | Boston Latin School (MA) | 34 | ? | |
| 1921 | L | Mechanics Arts HS | 0 | Saint John's Prep (MA) | 67 | ? | |
| 1921 | L | Mechanicsburg HS (OH) | 0 | London HS (OH) | 19 | ? | |
| 1921 | W | Medford HS (MA) | 7 | Brookline HS (MA) | 0 | ? | |
| 1921 | L | Medford HS (MA) | 0 | Cambridge Latin & HS (MA) | 21 | ? | |
| 1921 | W | Medford HS (MA) | 3 | Concord HS (MA) | 0 | ? | |
| 1921 | W | Medford HS (MA) | 7 | Everett HS (MA) | 0 | ? | |
| 1921 | W | Medford HS (MA) | 26 | Lawrence HS (MA) | 0 | ? | |
| 1921 | L | Medford HS (MA) | 7 | Malden HS (MA) | 10 | ? | |
| 1921 | L | Medford HS (MA) | 0 | Newton North HS (MA) | 7 | ? | |
| 1921 | T | Medford HS (MA) | 0 | Rindge Tech (MA) | 0 | ? | |
| 1921 | W | Medford HS (MA) | 30 | Saint John's Prep (MA) | 0 | ? | |
| 1921 | T | Medford HS (MA) | 0 | Somerville HS (MA) | 0 | ? | |
| 1921 | L | Medford HS (OR) | 7 | Ashland HS (OR) | 54 | ? | |
| 1921 | L | Medford HS (OR) | 0 | Ashland HS (OR) | 12 | ? | |
| 1921 | L | Media HS (PA) | 0 | Abington HS (PA) | 27 | ? | |
| 1921 | L | Media HS (PA) | 0 | Berwyn HS (PA) | 21 | ? | |
| 1921 | L | Media HS (PA) | 7 | Chester HS (PA) | 14 | ? | |
| 1921 | W | Media HS (PA) | 16 | Darby HS (PA) | 13 | ? | |
| 1921 | W | Media HS (PA) | 6 | Haverford HS (PA) | 0 | ? | |
| 1921 | L | Media HS (PA) | 0 | Lansdowne HS (PA) | 35 | ? | |
| 1921 | L | Media HS (PA) | 0 | Media HS Alumni (PA) | 13 | ? | |
| 1921 | L | Media HS (PA) | 7 | Ridley Park HS (PA) | 13 | ? | |
| 1921 | W | Media HS (PA) | 35 | Swarthmore HS (PA) | 0 | ? | |
| 1921 | W | Media HS Alumni (PA) | 13 | Media HS (PA) | 0 | ? | |
| 1921 | L | Medina HS (OH) | 0 | Lakewood HS (OH) | 68 | ? | |
| 1921 | W | Memphis (TN) | 12 | Brownsville Haywood County HS (TN) | 7 | Brownsville, TN | |
| 1921 | L | Memphis (TN) | 13 | Christian Brothers (TN) | 25 | Memphis, TN | |
| 1921 | W | Memphis (TN) | 20 | Ford-Kilvington HS (TN) | 0 | Memphis, TN | |
| 1921 | T | Memphis (TN) | 7 | Tennessee Medical College JV | 7 | Memphis, TN | |
| 1921 | L | Memphis (TN) | 7 | Union (TN) | 27 | Jackson, TN | |
| 1921 | W | Memphis (TN) | 14 | Wilson HS (AR) | 0 | Wilson, AR | |
| 1921 | L | Memphis (TN) | 0 | Mississippi | 82 | Oxford, MS | |
| 1921 | W | Memphis (TN) | 13 | Memphis Tech HS (TN) | 6 | Memphis, TN | |
| 1921 | L | Memphis (TN) | 0 | Memphis University School (TN) | 32 | Memphis, TN | |
| 1921 | L | Memphis (TN) | 0 | Arkansas St. | 19 | Jonesboro, AR | |
| 1921 | T | Memphis Central HS (TN) | 0 | Christian Brothers (TN) | 0 | ? | |
| 1921 | W | Memphis Central HS (TN) | 41 | Columbia HS (TN) | 6 | ? | |
| 1921 | W | Memphis Central HS (TN) | 21 | Jonesboro HS (AR) | 0 | ? | |
| 1921 | L | Memphis Central HS (TN) | 0 | Little Rock HS (AR) | 34 | ? | |
| 1921 | W | Memphis Central HS (TN) | 28 | Memphis Tech HS (TN) | 6 | ? | |
| 1921 | T | Memphis Central HS (TN) | 0 | Memphis University School (TN) | 0 | ? | |
| 1921 | L | Memphis Tech HS (TN) | 6 | Memphis Central HS (TN) | 28 | ? | |
| 1921 | L | Memphis Tech HS (TN) | 6 | Memphis (TN) | 13 | Memphis, TN | |
| 1921 | T | Memphis University School (TN) | 0 | Memphis Central HS (TN) | 0 | ? | |
| 1921 | W | Memphis University School (TN) | 32 | Memphis (TN) | 0 | Memphis, TN | |
| 1921 | W | Mendota HS (IL) | 20 | Kewanee HS (IL) | 0 | ? | |
| 1921 | L | Mendota HS (IL) | 3 | LaSalle-Peru HS (IL) | 14 | ? | |
| 1921 | L | Menlo Park HS (CA) | 0 | William Warren Military School (CA) | 14 | ? | |
| 1921 | T | Menominee HS (MI) | 6 | Saint Norbert (WI) | 6 | De Pere, WI | |
| 1921 | W | Mercer (GA) | 20 | Birmingham-Southern (AL) | 0 | Macon, GA | |
| 1921 | L | Mercer (GA) | 0 | Florida | 7 | Gainesville, FL | |
| 1921 | L | Mercer (GA) | 7 | Fort Benning (GA) | 24 | Macon, GA | |
| 1921 | W | Mercer (GA) | 41 | Stetson (FL) | 0 | Macon, GA | |
| 1921 | W | Mercer (GA) | 18 | Tennessee-Chattanooga | 0 | Macon, GA | |
| 1921 | L | Mercer (GA) | 0 | Georgia | 28 | Athens, GA | |
| 1921 | L | Mercer (GA) | 0 | Furman (SC) | 37 | Greenville, SC | |
| 1921 | L | Mercer (GA) | 0 | Vanderbilt (TN) | 42 | Nashville, TN | |
| 1921 | L | Mercer (GA) | 6 | Oglethorpe (GA) | 7 | Atlanta, GA | |
| 1921 | W | Mercersburg Academy (PA) | 14 | Baltimore Poly HS (MD) | 0 | ? | |
| 1921 | W | Mercersburg Academy (PA) | 48 | Gettysburg B Team (PA) | 0 | ? | |
| 1921 | W | Mercersburg Academy (PA) | 14 | Lehigh B Team (PA) | 0 | ? | |
| 1921 | L | Mercersburg Academy (PA) | 0 | Penn St. Freshmen | 19 | ? | |
| 1921 | W | Mercersburg Academy (PA) | 27 | Pennsylvania Freshmen | 0 | ? | |
| 1921 | W | Mercersburg Academy (PA) | 7 | Princeton Freshmen (NJ) | 0 | ? | |
| 1921 | W | Mercersburg Academy (PA) | 60 | Tarsus AC | 0 | ? | |
| 1921 | L | Mercersburg Academy JV (PA) | 0 | Franklin & Marshall Academy (PA) | 28 | ? | |
| 1921 | T | Mercersburg Academy JV (PA) | 7 | Shippensburg (PA) | 7 | ? | Shippensburg JV? |
| 1921 | L | Merchantville HS (NJ) | 0 | Bordentown Manual Training (NJ) | 46 | ? | |
| 1921 | L | Merchantville HS (NJ) | 0 | Moorestown Friends School (NJ) | 75 | ? | |
| 1921 | L | Merchantville HS (NJ) | 0 | Moorestown HS (NJ) | 78 | ? | |
| 1921 | L | Merchantville HS (NJ) | 0 | Palmyra HS (NJ) | 75 | ? | |
| 1921 | L | Meriden HS (CT) | 0 | Ansonia HS (CT) | 28 | ? | |
| 1921 | L | Meriden HS (CT) | 0 | New Britain HS (CT) | 3 | ? | |
| 1921 | W | Meriden HS (CT) | 13 | Port Chester HS (NY) | 12 | ? | |
| 1921 | L | Meriden HS (CT) | 7 | Torrington HS (CT) | 10 | ? | |
| 1921 | L | Meridian College (TX) | 0 | Burleson College (TX) | 13 | Greenville, TX | |
| 1921 | L | Meridian College (TX) | 0 | Dallas (TX) | 1 | ? | Meridian College Forfeits |
| 1921 | L | Meridian College (TX) | 0 | Daniel Baker (TX) | 34 | Brownwood, TX | |
| 1921 | L | Meridian College (TX) | 0 | John Tarleton College (TX) | 21 | ? | |
| 1921 | L | Meridian College (TX) | 3 | Terrill Prep School (TX) | 91 | ? | |
| 1921 | L | Meridian College (TX) | 0 | Abilene Christian (TX) | 37 | Meridian, TX | |
| 1921 | W | Merino HS (CO) | 19 | Sterling HS (CO) | 6 | ? | |
| 1921 | L | Merino HS (CO) | 0 | Sterling HS (CO) | 13 | ? | |
| 1921 | T | Merryville HS (LA) | 6 | Beaumont HS (TX) | 6 | ? | |
| 1921 | W | Mesa HS (AZ) | 88 | Northern Arizona | 0 | Mesa, AZ | |
| 1921 | L | Metuchen HS (NJ) | 0 | Pingry School (NJ) | 27 | ? | |
| 1921 | L | Metuchen HS (NJ) | 13 | Roselle HS (NJ) | 14 | ? | |
| 1921 | W | Miami (OH) | 15 | Cincinnati (OH) | 7 | Cincinnati, OH | |
| 1921 | W | Miami (OH) | 21 | Denison (OH) | 6 | Dayton, OH | |
| 1921 | W | Miami (OH) | 27 | Ohio Northern | 0 | Ada, OH | |
| 1921 | W | Miami (OH) | 56 | Ohio Wesleyan | 0 | Oxford, OH | |
| 1921 | W | Miami (OH) | 55 | Dayton (OH) | 0 | Oxford, OH | |
| 1921 | W | Miami (OH) | 21 | Otterbein (OH) | 0 | Oxford, OH | |
| 1921 | W | Miami (OH) | 14 | Wittenberg (OH) | 0 | Oxford, OH | |
| 1921 | W | Miami (OH) | 29 | Mount Union (OH) | 0 | Alliance, OH | |
| 1921 | W | Miami Military Institute (OH) | 26 | Cincinnati Woodward HS (OH) | 0 | ? | |
| 1921 | W | Miami Military Institute (OH) | 47 | McGuffey Prep (OH) | 0 | ? | |
| 1921 | W | Miami Military Institute (OH) | 46 | Milford HS (OH) | 0 | ? | |
| 1921 | W | Miami Military Institute (OH) | 20 | Saint Xavier Prep | 18 | ? | |
| 1921 | W | Miami Military Institute (OH) | 7 | University of Dayton Prep | 0 | ? | |
| 1921 | L | Miamisburg HS (OH) | 12 | Springfield HS (OH) | 14 | ? | |
| 1921 | L | Miamisburg HS (OH) | 0 | Xenia Central HS (OH) | 21 | ? | |
| 1921 | W | Michigan | 3 | Illinois | 0 | Champaign, IL | |
| 1921 | W | Michigan | 30 | Michigan St. | 0 | Ann Arbor, MI | |
| 1921 | W | Michigan | 38 | Minnesota | 0 | Ann Arbor, MI | |
| 1921 | L | Michigan | 0 | Ohio St. | 14 | Ann Arbor, MI | |
| 1921 | W | Michigan | 44 | Mount Union (OH) | 0 | Ann Arbor, MI | |
| 1921 | W | Michigan | 65 | Case Institute of Technology (OH) | 0 | Ann Arbor, MI | |
| 1921 | T | Michigan | 7 | Wisconsin | 7 | Madison, WI | |
| 1921 | L | Michigan City HS (IN) | 6 | Gary Froebel HS (IN) | 28 | ? | |
| 1921 | L | Michigan St. | 0 | Marquette (WI) | 7 | Milwaukee, WI | |
| 1921 | L | Michigan St. | 0 | Michigan | 30 | Ann Arbor, MI | |
| 1921 | L | Michigan St. | 0 | Notre Dame (IN) | 48 | South Bend, IN | |
| 1921 | W | Michigan St. | 17 | Western Michigan | 14 | East Lansing, MI | |
| 1921 | W | Michigan St. | 28 | Alma (MI) | 0 | East Lansing, MI | |
| 1921 | W | Michigan St. | 14 | South Dakota | 0 | East Lansing, MI | |
| 1921 | L | Michigan St. | 7 | Albion (MI) | 24 | East Lansing, MI | |
| 1921 | L | Michigan St. | 2 | Butler (IN) | 3 | Indianapolis, IN | |
| 1921 | W | Michigan St. Freshmen | 28 | Flint Central HS (MI) | 0 | ? | |
| 1921 | W | Michigan St. Freshmen | 21 | Lansing HS (MI) | 0 | ? | |
| 1921 | L | Michigan Tech | 6 | Northern Michigan | 7 | Marquette, MI | |
| 1921 | W | Michigan Tech | 12 | Northern Michigan | 7 | Houghton, MI | |
| 1921 | W | Middle Tennessee St. | 7 | Sewanee JV (TN) | 0 | Murfreesboro, TN | |
| 1921 | L | Middle Tennessee St. | 0 | Tennessee Medical College | 20 | Memphis, TN | |
| 1921 | T | Middle Tennessee St. | 0 | Union (TN) | 0 | Jackson, TN | |
| 1921 | W | Middle Tennessee St. | 14 | Vanderbilt JV (TN) | 13 | Murfreesboro, TN | |
| 1921 | L | Middle Tennessee St. | 0 | Vanderbilt (TN) | 34 | Nashville, TN | |
| 1921 | W | Middle Tennessee St. | 15 | Western Kentucky | 7 | Murfreesboro, TN | |
| 1921 | L | Middlebury (VT) | 0 | Harvard (MA) | 16 | Cambridge, MA | |
| 1921 | W | Middlebury (VT) | 3 | Norwich (VT) | 0 | Middlebury, VT | |
| 1921 | W | Middlebury (VT) | 26 | Saint Lawrence (NY) | 6 | Canton, NY | |
| 1921 | W | Middlebury (VT) | 7 | Williams (MA) | 3 | Williamstown, MA | |
| 1921 | L | Middlebury (VT) | 3 | Dartmouth (NH) | 28 | Hanover, NH | |
| 1921 | W | Middlebury (VT) | 14 | Clarkson (NY) | 0 | Middlebury, VT | |
| 1921 | L | Middlebury (VT) | 0 | Army (NY) | 19 | West Point, NY | |
| 1921 | L | Middlebury (VT) | 7 | Vermont | 14 | Burlington, VT | |
| 1921 | L | Middlesboro HS (KY) | 0 | Cumberland (KY) | 51 | ? | |
| 1921 | W | Middlesex School (MA) | 49 | Allen Military School (MA) | 0 | ? | |
| 1921 | W | Middlesex School (MA) | 13 | Browne & Nichols School (MA) | 0 | ? | |
| 1921 | W | Middlesex School (MA) | 34 | Dorchester HS (MA) | 0 | ? | |
| 1921 | W | Middlesex School (MA) | 34 | Governor Dummer Academy (MA) | 0 | ? | |
| 1921 | W | Middlesex School (MA) | 14 | Groton HS (NY) | 3 | ? | |
| 1921 | W | Middlesex School (MA) | 14 | Saint George HS | 0 | ? | |
| 1921 | L | Middlesex School (MA) | 6 | Saint Marks School (MA) | 13 | ? | |
| 1921 | L | Middletown HS (NJ) | 7 | Ridgewood HS (NJ) | 14 | ? | |
| 1921 | W | Middletown HS (NY) | 18 | Eastman Business College (NY) | 0 | ? | |
| 1921 | W | Middletown HS (NY) | 61 | Highland Falls HS (NY) | 7 | ? | |
| 1921 | W | Middletown HS (NY) | 7 | Newburgh Free Academy (NY) | 2 | ? | |
| 1921 | W | Middletown HS (NY) | 13 | Port Jervis HS (NY) | 0 | ? | |
| 1921 | W | Middletown HS (NY) | 20 | Poughkeepsie HS (NY) | 0 | ? | |
| 1921 | W | Middletown HS (NY) | 46 | Ramsey HS (NJ) | 0 | ? | |
| 1921 | L | Middletown HS (NY) | 7 | Ridgewood HS (NY) | 14 | ? | |
| 1921 | W | Middletown HS (OH) | 31 | Cincinnati Hughes HS (OH) | 27 | ? | |
| 1921 | W | Middletown HS (OH) | 41 | Springfield HS (OH) | 0 | ? | |
| 1921 | L | Midland College (TX) | 0 | Abilene Christian (TX) | 7 | Abilene, TX | |
| 1921 | W | Midland HS (PA) | 3 | Monaca HS (PA) | 0 | ? | |
| 1921 | L | Midland Lutheran (NE) | 6 | Doane (NE) | 10 | ? | |
| 1921 | W | Midland Lutheran (NE) | 26 | Nebraska Central | 6 | ? | |
| 1921 | W | Midland Lutheran (NE) | 13 | Nebraska-Kearney | 0 | ? | |
| 1921 | W | Midland Lutheran (NE) | 3 | Nebraska-Omaha | 6 | Omaha, NE | Nebraska-Omaha Forfeits |
| 1921 | L | Midland Lutheran (NE) | 0 | Peru St. (NE) | 14 | ? | |
| 1921 | L | Midland Lutheran (NE) | 0 | Wayne St. (NE) | 7 | ? | |
| 1921 | L | Midland Lutheran (NE) | 0 | York (NE) | 6 | ? | |
| 1921 | W | Milaca HS (MN) | 21 | Anoka HS (MN) | 0 | ? | |
| 1921 | W | Milaca HS (MN) | 48 | Cambridge HS (OH) | 0 | ? | |
| 1921 | W | Milaca HS (MN) | 6 | Elk River HS (MN) | 0 | ? | |
| 1921 | W | Milaca HS (MN) | 52 | Princeton HS (MN) | 0 | ? | |
| 1921 | T | Milaca HS (MN) | 13 | Saint Cloud HS (MN) | 13 | ? | |
| 1921 | T | Milaca HS (MN) | 14 | Saint Cloud HS (MN) | 14 | ? | |
| 1921 | T | Miles (AL) | 7 | Alabama St. | 7 | ? | |
| 1921 | T | Miles (AL) | 0 | Stillman (AL) | 0 | ? | |
| 1921 | L | Miles (AL) | 0 | Talladega (AL) | 27 | ? | |
| 1921 | W | Miles City HS (MT) | 20 | Forsyth HS (MT) | 6 | ? | |
| 1921 | T | Milford Academy (NY) | 0 | Pawling School (NY) | 0 | ? | |
| 1921 | T | Milford Academy (NY) | 7 | Pomfret School (CT) | 7 | ? | |
| 1921 | W | Milford HS (CT) | 7 | Roxbury School (CT) | 6 | ? | |
| 1921 | W | Milford HS (MA) | 21 | Hudson HS (MA) | 0 | ? | |
| 1921 | L | Milford HS (MA) | 0 | Natick HS (MA) | 7 | ? | |
| 1921 | L | Milford HS (OH) | 0 | Cincinnati Hughes HS (OH) | 40 | ? | |
| 1921 | L | Milford HS (OH) | 0 | Miami Military Institute (OH) | 46 | ? | |
| 1921 | T | Millersville (PA) | 0 | Bloomsburg (PA) | 0 | Bloomsburg, PA | |
| 1921 | L | Millersville (PA) | 7 | Franklin & Marshall Academy (PA) | 13 | ? | |
| 1921 | W | Millersville (PA) | 34 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | W | Millersville (PA) | 38 | West Chester (PA) | 7 | ? | |
| 1921 | T | Millersville (PA) | 7 | York HS (PA) | 7 | ? | |
| 1921 | T | Millersville (PA) | 7 | Shippensburg (PA) | 7 | Millersville, PA | |
| 1921 | L | Milligan (TN) | 0 | Carson-Newman (TN) | 6 | ? | |
| 1921 | L | Milligan (TN) | 7 | East Tennessee St. | 12 | ? | |
| 1921 | W | Milligan (TN) | 21 | Johnson City All-Stars (TN) | 0 | ? | |
| 1921 | L | Milligan (TN) | 0 | Maryville (TN) | 54 | Maryville, TN | |
| 1921 | W | Milligan (TN) | 14 | Tusculum (TN) | 0 | ? | |
| 1921 | L | Milligan (TN) | 6 | Emory & Henry (VA) | 31 | Emory, VA | |
| 1921 | W | Millikin (IL) | 28 | Augustana (IL) | 0 | Rock Island, IL | |
| 1921 | W | Millikin (IL) | 7 | Knox (IL) | 0 | Galesburg, IL | |
| 1921 | L | Millikin (IL) | 3 | Lake Forest (IL) | 10 | Decatur, IL | |
| 1921 | W | Millikin (IL) | 7 | Missouri S&T | 0 | Rolla, MO | |
| 1921 | W | Millikin (IL) | 69 | Shurtleff (IL) | 0 | Alton, IL | |
| 1921 | L | Millikin (IL) | 3 | Wabash (IN) | 14 | Crawfordsville, IN | |
| 1921 | W | Millikin (IL) | 63 | Northern Illinois | 0 | DeKalb, IL | |
| 1921 | T | Millikin (IL) | 7 | Illinois Wesleyan | 7 | Decatur, IL | |
| 1921 | L | Millsaps (MS) | 7 | Centenary (LA) | 21 | ? | |
| 1921 | L | Millsaps (MS) | 0 | Mississippi | 49 | Oxford, MS | |
| 1921 | W | Millsaps (MS) | 27 | Southern Mississippi | 0 | Jackson, MS | |
| 1921 | L | Millsaps (MS) | 0 | Tennessee Medical College | 14 | ? | |
| 1921 | T | Millsaps (MS) | 7 | Birmingham-Southern (AL) | 7 | Jackson, MS | |
| 1921 | L | Millsaps (MS) | 0 | Samford (AL) | 45 | Birmingham, AL | |
| 1921 | L | Millsaps (MS) | 0 | Mississippi College | 56 | Clinton, MS | |
| 1921 | L | Millville HS (NJ) | 0 | Bridgeton HS (NJ) | 6 | ? | |
| 1921 | L | Millville HS (NJ) | 0 | Collingswood HS (NJ) | 35 | ? | |
| 1921 | L | Millville HS (NJ) | 0 | Moorestown HS (NJ) | 14 | ? | |
| 1921 | L | Millville HS (NJ) | 0 | Penns Grove HS (NJ) | 21 | ? | |
| 1921 | T | Millville HS (NJ) | 0 | Vineland HS (NJ) | 0 | ? | |
| 1921 | L | Millville HS (NJ) | 0 | Woodbury HS (NJ) | 7 | ? | |
| 1921 | W | Millville HS (NJ) | 13 | Woodstown HS (NJ) | 0 | ? | |
| 1921 | L | Milton (WI) | 0 | Northwestern (WI) | 20 | Milton, WI | |
| 1921 | L | Milton (WI) | 0 | Wisconsin-Milwaukee | 44 | Milwaukee, WI | |
| 1921 | L | Milton (WI) | 0 | Wisconsin-Whitewater | 34 | Whitewater, WI | |
| 1921 | W | Milton Academy (MA) | 18 | Boston Hyde Park HS (MA) | 0 | ? | |
| 1921 | W | Milton Academy (MA) | 7 | Browne & Nichols School (MA) | 0 | ? | |
| 1921 | L | Milton Academy (MA) | 0 | Pomfret School (CT) | 14 | ? | |
| 1921 | W | Milton HS (IA) | 14 | Keokuk HS (IA) | 0 | ? | |
| 1921 | L | Milton HS (MA) | 0 | Norwood HS (MA) | 13 | ? | |
| 1921 | L | Milton HS (MA) | 0 | Quincy HS (MA) | 20 | ? | |
| 1921 | T | Milton HS (MA) | 0 | Thayer Academy (MA) | 0 | ? | |
| 1921 | L | Milton HS (OR) | 13 | Pendleton HS (OR) | 20 | ? | |
| 1921 | L | Milton HS (PA) | 0 | Harrisburg Tech HS (PA) | 69 | ? | |
| 1921 | L | Milwaukee County School of Agriculture (WI) | 0 | Watertown HS (WI) | 34 | ? | |
| 1921 | L | Milwaukee East Division HS (WI) | 0 | Milwaukee South Division HS (WI) | 7 | ? | |
| 1921 | L | Milwaukee East Division HS (WI) | 0 | Milwaukee Washington HS (WI) | 58 | ? | |
| 1921 | L | Milwaukee North Division HS (WI) | 0 | Milwaukee South Division HS (WI) | 52 | ? | |
| 1921 | L | Milwaukee North Division HS (WI) | 0 | Milwaukee Washington HS (WI) | 55 | ? | |
| 1921 | T | Milwaukee Riverside HS (WI) | 0 | Loyola Academy (IL) | 0 | ? | |
| 1921 | L | Milwaukee School of Engineering (WI) | 13 | Saint Louis (MO) | 14 | Saint Louis, MO | |
| 1921 | W | Milwaukee School of Engineering (WI) | 14 | Wisconsin Tech | 6 | Milwaukee, WI | |
| 1921 | L | Milwaukee School of Engineering (WI) | 7 | Wisconsin-Stevens Point | 9 | Stevens Point, WI | |
| 1921 | L | Milwaukee School of Engineering (WI) | 0 | Valparaiso (IN) | 14 | Valparaiso, IN | |
| 1921 | L | Milwaukee School of Engineering (WI) | 0 | Western Michigan | 62 | Kalamazoo, MI | |
| 1921 | W | Milwaukee South Division HS (WI) | 28 | Kenosha HS (WI) | 7 | ? | |
| 1921 | W | Milwaukee South Division HS (WI) | 67 | Milwaukee Bay View HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee South Division HS (WI) | 7 | Milwaukee East Division HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee South Division HS (WI) | 52 | Milwaukee North Division HS (WI) | 0 | ? | |
| 1921 | T | Milwaukee South Division HS (WI) | 0 | Milwaukee Washington HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee South Division HS (WI) | 6 | Milwaukee West Division HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee South Division HS (WI) | 67 | Mukwonago HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee South Division HS (WI) | 23 | Wayland Academy (WI) | 0 | ? | |
| 1921 | L | Milwaukee Tech HS (WI) | 0 | Milwaukee Washington HS (WI) | 83 | ? | |
| 1921 | W | Milwaukee Washington HS (WI) | 69 | Kenosha HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee Washington HS (WI) | 93 | Milwaukee Bay View HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee Washington HS (WI) | 58 | Milwaukee East Division HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee Washington HS (WI) | 55 | Milwaukee North Division HS (WI) | 0 | ? | |
| 1921 | T | Milwaukee Washington HS (WI) | 0 | Milwaukee South Division HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee Washington HS (WI) | 83 | Milwaukee Tech HS (WI) | 0 | ? | |
| 1921 | W | Milwaukee Washington HS (WI) | 4 | Milwaukee West Side HS (WI) | 0 | ? | |
| 1921 | L | Milwaukee West Division HS (WI) | 0 | Milwaukee South Division HS (WI) | 6 | ? | |
| 1921 | L | Milwaukee West Side HS (WI) | 0 | Milwaukee Washington HS (WI) | 4 | ? | |
| 1921 | L | Minden HS (NE) | 0 | Holdrege HS (NE) | 33 | ? | |
| 1921 | L | Minden HS (NE) | 0 | Holdrege HS (NE) | 13 | ? | |
| 1921 | L | Mineola Aviators | 0 | SUNY-Farmingdale (NY) | 48 | ? | |
| 1921 | W | Minersville HS (PA) | 19 | Ashland HS (PA) | 14 | ? | |
| 1921 | W | Minersville HS (PA) | 35 | Coaldale HS (PA) | 0 | ? | |
| 1921 | W | Minersville HS (PA) | 27 | Lykens HS (PA) | 7 | ? | |
| 1921 | L | Minersville HS (PA) | 0 | Mount Carmel HS (PA) | 61 | ? | |
| 1921 | L | Minersville HS (PA) | 0 | Mount Carmel HS (PA) | 61 | ? | |
| 1921 | W | Minersville HS (PA) | 8 | Pottstown HS (PA) | 6 | ? | |
| 1921 | W | Minersville HS (PA) | 24 | Shamokin HS (PA) | 0 | ? | |
| 1921 | W | Minersville HS (PA) | 14 | Shenandoah HS (PA) | 0 | ? | |
| 1921 | L | Minersville HS (PA) | 7 | Sunbury HS (PA) | 18 | ? | |
| 1921 | T | Minersville HS (PA) | 6 | Tamaqua HS (PA) | 6 | ? | |
| 1921 | W | Mingo HS (OH) | 18 | Follansbee HS (WV) | 0 | ? | |
| 1921 | L | Mingo HS (OH) | 0 | Martins Ferry HS (OH) | 6 | ? | |
| 1921 | L | Mining & Mechanical Institute (PA) | 0 | Allentown Prep School (PA) | 39 | ? | |
| 1921 | L | Mining & Mechanical Institute (PA) | 0 | Bethlehem HS (PA) | 45 | ? | |
| 1921 | L | Minneapolis Central HS (MN) | 3 | Minneapolis East HS (MN) | 7 | ? | |
| 1921 | W | Minneapolis Central HS (MN) | 20 | Minneapolis North HS (MN) | 0 | ? | |
| 1921 | W | Minneapolis Central HS (MN) | 3 | Minneapolis South HS (MN) | 0 | ? | |
| 1921 | L | Minneapolis Central HS (MN) | 6 | Minneapolis West HS (MN) | 13 | ? | |
| 1921 | W | Minneapolis Central HS (MN) | 13 | Saint Paul Central HS (MN) | 7 | ? | |
| 1921 | W | Minneapolis East HS (MN) | 7 | Minneapolis Central HS (MN) | 3 | ? | |
| 1921 | W | Minneapolis East HS (MN) | 28 | Minneapolis North HS (MN) | 7 | ? | |
| 1921 | W | Minneapolis East HS (MN) | 28 | Minneapolis South HS (MN) | 0 | ? | |
| 1921 | W | Minneapolis East HS (MN) | 7 | Minneapolis West HS (MN) | 0 | ? | |
| 1921 | W | Minneapolis East HS (MN) | 32 | Minnesota Freshmen | 0 | ? | |
| 1921 | W | Minneapolis East HS (MN) | 34 | Saint Thomas HS | 0 | ? | |
| 1921 | T | Minneapolis North HS (MN) | 7 | Dunwoody College of Tech. (MN) | 7 | ? | |
| 1921 | L | Minneapolis North HS (MN) | 0 | Minneapolis Central HS (MN) | 20 | ? | |
| 1921 | L | Minneapolis North HS (MN) | 7 | Minneapolis East HS (MN) | 28 | ? | |
| 1921 | L | Minneapolis South HS (MN) | 0 | Minneapolis Central HS (MN) | 3 | ? | |
| 1921 | L | Minneapolis South HS (MN) | 0 | Minneapolis East HS (MN) | 28 | ? | |
| 1921 | W | Minneapolis West HS (MN) | 13 | Minneapolis Central HS (MN) | 6 | ? | |
| 1921 | L | Minneapolis West HS (MN) | 0 | Minneapolis East HS (MN) | 7 | ? | |
| 1921 | W | Minnesota | 6 | Indiana | 0 | Minneapolis, MN | |
| 1921 | L | Minnesota | 0 | Michigan | 38 | Ann Arbor, MI | |
| 1921 | L | Minnesota | 0 | Ohio St. | 27 | Columbus, OH | |
| 1921 | L | Minnesota | 0 | Wisconsin | 35 | Madison, WI | |
| 1921 | W | Minnesota | 19 | North Dakota | 0 | Minneapolis, MN | |
| 1921 | L | Minnesota | 7 | Iowa | 41 | Minneapolis, MN | |
| 1921 | W | Minnesota | 28 | Northwestern (IL) | 0 | Minneapolis, MN | |
| 1921 | L | Minnesota Freshmen | 0 | Minneapolis East HS (MN) | 32 | ? | |
| 1921 | L | Mishawaka HS (IN) | 0 | Gary Froebel HS (IN) | 7 | ? | |
| 1921 | L | Mississippi | 0 | Havana AC (Cuba) | 14 | Havana, Cuba | Bacardi Bowl |
| 1921 | W | Mississippi | 49 | Millsaps (MS) | 0 | Oxford, MS | |
| 1921 | L | Mississippi | 0 | Mississippi St. | 21 | Greenwood, MS | |
| 1921 | W | Mississippi | 35 | Rhodes (TN) | 0 | Oxford, MS | |
| 1921 | L | Mississippi | 6 | Tennessee Medical College | 24 | Memphis, TN | |
| 1921 | W | Mississippi | 82 | Memphis (TN) | 0 | Oxford, MS | |
| 1921 | L | Mississippi | 7 | Mississippi College | 27 | Vicksburg, MS | |
| 1921 | L | Mississippi | 0 | Tulane (LA) | 26 | New Orleans, LA | |
| 1921 | L | Mississippi | 0 | Louisiana St. | 21 | Baton Rouge, LA | |
| 1921 | W | Mississippi College | 27 | Birmingham-Southern (AL) | 6 | Birmingham, AL | |
| 1921 | T | Mississippi College | 7 | Florida | 7 | Jacksonville, FL | |
| 1921 | L | Mississippi College | 13 | Mississippi St. | 14 | Jackson, MS | |
| 1921 | W | Mississippi College | 28 | Spring Hill (AL) | 7 | Mobile, AL | |
| 1921 | W | Mississippi College | 34 | Union (TN) | 0 | Clinton, MS | |
| 1921 | W | Mississippi College | 14 | Tulane (LA) | 0 | New Orleans, LA | |
| 1921 | L | Mississippi College | 0 | Baylor (TX) | 24 | Dallas, TX | |
| 1921 | W | Mississippi College | 27 | Mississippi | 7 | Vicksburg, MS | |
| 1921 | W | Mississippi College | 68 | Louisiana College | 0 | Clinton, MS | |
| 1921 | W | Mississippi College | 56 | Millsaps (MS) | 0 | Clinton, MS | |
| 1921 | L | Mississippi Industrial Training School | 0 | Lane (TN) | 7 | ? | |
| 1921 | T | Mississippi St. | 7 | Alabama | 7 | Birmingham, AL | |
| 1921 | W | Mississippi St. | 21 | Mississippi | 0 | Greenwood, MS | |
| 1921 | W | Mississippi St. | 14 | Mississippi College | 13 | Jackson, MS | |
| 1921 | L | Mississippi St. | 0 | Tulane (LA) | 7 | New Orleans, LA | |
| 1921 | W | Mississippi St. | 20 | Birmingham-Southern (AL) | 7 | Starkville, MS | |
| 1921 | L | Mississippi St. | 14 | Louisiana St. | 17 | Starkville, MS | |
| 1921 | L | Mississippi St. | 7 | Tennessee | 14 | Memphis, TN | |
| 1921 | W | Mississippi St. | 21 | Ouachita Baptist (AR) | 6 | Starkville, MS | |
| 1921 | L | Mississippi St. | 7 | Texas | 54 | Austin, TX | |
| 1921 | W | Missouri | 6 | Drake (IA) | 0 | Columbia, MO | |
| 1921 | W | Missouri | 17 | Iowa St. | 14 | Columbia, MO | |
| 1921 | L | Missouri | 9 | Kansas | 15 | Lawrence, KS | |
| 1921 | L | Missouri | 5 | Kansas St. | 7 | Manhattan, KS | |
| 1921 | W | Missouri | 36 | Oklahoma St. | 0 | Columbia, MO | |
| 1921 | W | Missouri | 7 | Washington (MO) | 0 | Saint Louis, MO | |
| 1921 | W | Missouri | 32 | Saint Louis (MO) | 0 | Saint Louis, MO | |
| 1921 | W | Missouri | 24 | Oklahoma | 14 | Columbia, MO | |
| 1921 | W | Missouri Military Academy | 28 | Central Wesleyan (MO) | 6 | Warrenton, MO | |
| 1921 | L | Missouri Military Academy | 6 | Chillicothe Business College (MO) | 14 | Mexico, MO | |
| 1921 | W | Missouri Military Academy | 7 | Kemper Military School (MO) | 6 | ? | |
| 1921 | L | Missouri Military Academy | 0 | Kirksville Osteopath (MO) | 40 | ? | |
| 1921 | L | Missouri Military Academy | 10 | Missouri Valley | 26 | ? | |
| 1921 | W | Missouri Military Academy | 68 | Saint Louis University HS (MO) | 0 | ? | |
| 1921 | L | Missouri Military Academy | 7 | Westminster (MO) | 18 | ? | |
| 1921 | W | Missouri Military Academy | 2 | Wentworth Military Academy (MO) | 0 | ? | |
| 1921 | W | Missouri S&T | 21 | Central Methodist (MO) | 2 | Rolla, MO | |
| 1921 | L | Missouri S&T | 0 | Millikin (IL) | 7 | Rolla, MO | |
| 1921 | W | Missouri S&T | 66 | Missouri St. | 6 | Rolla, MO | |
| 1921 | L | Missouri S&T | 3 | Missouri Wesleyan | 14 | Rolla, MO | |
| 1921 | L | Missouri S&T | 0 | Washington (MO) | 10 | Saint Louis, MO | |
| 1921 | L | Missouri S&T | 3 | Rose-Hulman Tech (IN) | 7 | Rolla, MO | |
| 1921 | W | Missouri S&T | 24 | Southeast Missouri St. | 0 | Cape Girardeau, MO | |
| 1921 | W | Missouri S&T | 31 | Drury (MO) | 0 | Rolla, MO | |
| 1921 | W | Missouri St. | 16 | Drury (MO) | 13 | Springfield, MO | |
| 1921 | L | Missouri St. | 6 | Missouri S&T | 66 | Rolla, MO | |
| 1921 | W | Missouri St. | 14 | Missouri Valley | 7 | Marshall, MO | |
| 1921 | W | Missouri St. | 7 | Southeast Missouri St. | 0 | Springfield, MO | |
| 1921 | L | Missouri St. | 0 | Tarkio (MO) | 7 | Springfield, MO | 2-0? |
| 1921 | L | Missouri St. | 0 | William Jewell (MO) | 10 | Springfield, MO | |
| 1921 | L | Missouri St. | 0 | Arkansas Tech | 21 | Russellville, AR | |
| 1921 | L | Missouri St. | 0 | Missouri Wesleyan | 10 | Springfield, MO | |
| 1921 | T | Missouri Valley | 7 | Drury (MO) | 7 | Marshall, MO | |
| 1921 | W | Missouri Valley | 26 | Missouri Military Academy | 10 | ? | |
| 1921 | L | Missouri Valley | 7 | Missouri St. | 14 | Marshall, MO | |
| 1921 | W | Missouri Valley | 55 | Northwest Missouri St. | 14 | ? | |
| 1921 | L | Missouri Valley | 0 | Truman St. (MO) | 20 | Kirksville, MO | |
| 1921 | T | Missouri Valley | 7 | Wentworth Military Academy (MO) | 7 | ? | |
| 1921 | T | Missouri Valley | 0 | Westminster (MO) | 0 | ? | |
| 1921 | W | Missouri Wesleyan | 6 | Benedictine (KS) | 0 | Atchison, KS | |
| 1921 | W | Missouri Wesleyan | 26 | Central Methodist (MO) | 6 | Cameron, MO | |
| 1921 | W | Missouri Wesleyan | 14 | Missouri S&T | 3 | Rolla, MO | |
| 1921 | L | Missouri Wesleyan | 0 | William Jewell (MO) | 3 | Cameron, MO | |
| 1921 | W | Missouri Wesleyan | 23 | Tarkio (MO) | 7 | Cameron, MO | |
| 1921 | W | Missouri Wesleyan | 36 | Westminster (MO) | 0 | Saint Joseph, MO | |
| 1921 | W | Missouri Wesleyan | 10 | Missouri St. | 0 | Springfield, MO | |
| 1921 | W | Missouri Wesleyan | 65 | Culver-Stockton (MO) | 0 | Cameron, MO | |
| 1921 | W | MIT (MA) | 6 | Providence (RI) | 0 | Cambridge, MA | |
| 1921 | L | MIT Freshmen (MA) | 0 | Saint John's Prep (MA) | 14 | ? | |
| 1921 | L | Mobile Tigers (AL) | 0 | Talladega (AL) | 21 | ? | |
| 1921 | L | Modesto JC (CA) | 0 | Fresno St. (CA) | 28 | Modesto, CA | |
| 1921 | L | Mohegan Lake HS (NY) | 12 | Drum Hill HS (NY) | 33 | ? | |
| 1921 | L | Mohegan Lake HS (NY) | 0 | Hackley School (NY) | 28 | ? | |
| 1921 | W | Moline HS (IL) | 17 | LaSalle-Peru HS (IL) | 14 | ? | |
| 1921 | W | Moline HS (IL) | 9 | Peoria Central HS (IL) | 0 | ? | |
| 1921 | L | Momence HS (IL) | 14 | LaSalle-Peru HS (IL) | 82 | ? | |
| 1921 | W | Monaca HS (PA) | 33 | Ambridge HS (PA) | 0 | ? | |
| 1921 | W | Monaca HS (PA) | 25 | Beaver HS (PA) | 6 | ? | |
| 1921 | W | Monaca HS (PA) | 20 | Chester HS (PA) | 0 | ? | |
| 1921 | W | Monaca HS (PA) | 53 | Coraopolis HS (PA) | 0 | ? | |
| 1921 | W | Monaca HS (PA) | 7 | East Palestine HS (OH) | 6 | ? | |
| 1921 | W | Monaca HS (PA) | 41 | Freedom HS (PA) | 0 | ? | |
| 1921 | L | Monaca HS (PA) | 0 | Midland HS (PA) | 3 | ? | |
| 1921 | W | Monaca HS (PA) | 3 | Monaca HS Alumni (PA) | 0 | ? | |
| 1921 | L | Monaca HS (PA) | 0 | Rochester HS (PA) | 18 | ? | |
| 1921 | T | Monaca HS (PA) | 0 | Sewickley HS (PA) | 0 | ? | |
| 1921 | W | Monaca HS (PA) | 27 | Woodlawn HS | 7 | ? | |
| 1921 | L | Monaca HS Alumni (PA) | 0 | Monaca HS (PA) | 3 | ? | |
| 1921 | W | Monessen HS (PA) | 20 | Duquesne HS (PA) | 0 | ? | |
| 1921 | L | Monessen HS (PA) | 6 | Rochester HS (PA) | 7 | ? | |
| 1921 | W | Monett HS (MO) | 12 | Joplin HS (MO) | 0 | ? | |
| 1921 | W | Monett HS (MO) | 56 | Rogers HS (AR) | 0 | ? | |
| 1921 | L | Monmouth (IL) | 7 | Augustana (IL) | 19 | Monmouth, IL | |
| 1921 | L | Monmouth (IL) | 7 | Knox (IL) | 17 | Galesburg, IL | |
| 1921 | L | Monmouth (IL) | 0 | Lake Forest (IL) | 26 | Lake Forest, IL | |
| 1921 | L | Monmouth (IL) | 0 | Lombard (IL) | 90 | Galesburg, IL | |
| 1921 | L | Monmouth (IL) | 0 | North Central (IL) | 2 | Monmouth, IL | |
| 1921 | L | Monmouth (IL) | 0 | Eureka (IL) | 19 | Monmouth, IL | |
| 1921 | L | Monmouth (IL) | 7 | Illinois College | 38 | Jacksonville, IL | |
| 1921 | W | Monmouth (IL) | 7 | Iowa Wesleyan | 3 | Mount Pleasant, IA | |
| 1921 | W | Monmouth HS (IL) | 32 | Kewanee HS (IL) | 7 | ? | |
| 1921 | T | Monmouth HS (IL) | 0 | Quincy HS (IL) | 0 | ? | |
| 1921 | W | Monroe Agricultural College (GA) | 14 | Atlanta Boy's HS (GA) | 0 | ? | |
| 1921 | L | Monroe City HS (MO) | 0 | Hannibal HS (MO) | 70 | ? | |
| 1921 | L | Monroe HS (NC) | 0 | Asheville HS (NC) | 34 | ? | |
| 1921 | W | Monroe HS (WA) | 40 | Granite Falls HS (WA) | 0 | ? | |
| 1921 | L | Montabello | 0 | San Diego HS (CA) | 70 | ? | |
| 1921 | T | Montana | 0 | Gonzaga (WA) | 0 | Spokane, WA | |
| 1921 | W | Montana | 7 | North Dakota St. | 6 | Missoula, MT | |
| 1921 | L | Montana | 7 | Washington | 28 | Seattle, WA | |
| 1921 | L | Montana | 6 | Whitman (WA) | 14 | Missoula, MT | |
| 1921 | L | Montana | 7 | Idaho | 35 | Moscow, ID | |
| 1921 | W | Montana | 25 | Idaho St. | 0 | Missoula, MT | |
| 1921 | W | Montana | 14 | Montana St. | 7 | Bozeman, MT | |
| 1921 | L | Montana St. | 2 | Gonzaga (WA) | 7 | Spokane, WA | |
| 1921 | W | Montana St. | 26 | Montana Tech | 0 | Bozeman, MT | |
| 1921 | L | Montana St. | 7 | Utah St. | 30 | Logan, UT | |
| 1921 | L | Montana St. | 0 | Montana Wesleyan | 16 | Helena, MT | |
| 1921 | W | Montana St. | 21 | Carroll (MT) | 7 | Bozeman, MT | |
| 1921 | L | Montana St. | 7 | Montana | 14 | Bozeman, MT | |
| 1921 | W | Montana Tech | 28 | Englewood AC (MT) | 0 | ? | |
| 1921 | L | Montana Tech | 0 | Montana St. | 26 | Bozeman, MT | |
| 1921 | T | Montana Tech | 0 | Montana Wesleyan | 0 | Butte, MT | |
| 1921 | T | Montana Tech | 0 | South Dakota Tech | 0 | Rapid City, SD | |
| 1921 | L | Montana Tech | 0 | Utah St. | 3 | Butte, MT | |
| 1921 | W | Montana Tech | 26 | Carroll (MT) | 0 | Butte, MT | |
| 1921 | W | Montana Tech | 55 | Billings Poly (MT) | 0 | Billings, MT | |
| 1921 | W | Montana Tech | 23 | Black Hills St. (SD) | 14 | Lead, SD | |
| 1921 | W | Montana Wesleyan | 98 | Billings Poly (MT) | 0 | Helena, MT | |
| 1921 | W | Montana Wesleyan | 20 | Carroll (MT) | 0 | Helena, MT | |
| 1921 | L | Montana Wesleyan | 7 | College of Idaho | 28 | Caldwell, ID | |
| 1921 | W | Montana Wesleyan | 27 | Gooding (ID) | 7 | Gooding, ID | |
| 1921 | T | Montana Wesleyan | 0 | Montana Tech | 0 | Butte, MT | |
| 1921 | W | Montana Wesleyan | 16 | Montana St. | 0 | Helena, MT | |
| 1921 | W | Montana Wesleyan | 28 | Carroll (MT) | 6 | Helena, MT | |
| 1921 | W | Montclair HS (NJ) | 37 | Asbury Park HS (NJ) | 10 | ? | |
| 1921 | W | Montclair HS (NJ) | 16 | Battin HS (NJ) | 12 | ? | |
| 1921 | L | Montclair HS (NJ) | 21 | East Orange HS (NJ) | 26 | ? | |
| 1921 | W | Montclair HS (NJ) | 55 | Jamaica HS (NY) | 0 | ? | |
| 1921 | W | Montclair HS (NJ) | 28 | Jersey City Dickinson HS (NJ) | 2 | ? | |
| 1921 | L | Montclair HS (NJ) | 0 | Newark Barringer HS (NJ) | 13 | ? | |
| 1921 | L | Montclair HS (NJ) | 6 | Newark Central HS (NJ) | 7 | ? | |
| 1921 | W | Montclair HS (NJ) | 27 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | T | Montclair HS (NJ) | 7 | Plainfield HS (NJ) | 7 | ? | |
| 1921 | L | Montclair HS (NJ) | 0 | Rutherford HS (NJ) | 28 | ? | |
| 1921 | L | Montclair HS JV (NJ) | 0 | Chatham HS (NJ) | 41 | ? | |
| 1921 | L | Montclair HS JV (NJ) | 7 | West Orange HS (NJ) | 14 | ? | |
| 1921 | W | Montclair Military Academy (NJ) | 51 | Bordentown Military Institute (NJ) | 6 | ? | |
| 1921 | W | Montclair Military Academy (NJ) | 27 | Carlton Academy (NJ) | 0 | ? | |
| 1921 | W | Montclair Military Academy (NJ) | 19 | East Orange HS (NJ) | 7 | ? | |
| 1921 | W | Montclair Military Academy (NJ) | 40 | Hoboken Stevens Prep HS (NJ) | 0 | ? | |
| 1921 | W | Montclair Military Academy (NJ) | 42 | Jersey City Lincoln HS (NJ) | 0 | ? | |
| 1921 | W | Montclair Military Academy (NJ) | 20 | Peekskill Military Academy (NY) | 0 | ? | |
| 1921 | W | Montclair Military Academy (NJ) | 27 | Ridgewood HS (NJ) | 7 | ? | |
| 1921 | L | Montclair Military Academy (NJ) | 7 | Rutgers Prep School (NJ) | 14 | ? | |
| 1921 | L | Monte Vista HS (CO) | 0 | Gunnison HS (CO) | 62 | ? | |
| 1921 | L | Montesano HS (WA) | 0 | Chehalis HS (WA) | 6 | ? | |
| 1921 | W | Montevideo HS (MN) | 33 | Benson HS (MN) | 0 | ? | |
| 1921 | W | Montevideo HS (MN) | 12 | Glenwood HS (MN) | 0 | ? | |
| 1921 | W | Montevideo HS (MN) | 54 | Hancock HS (MN) | 0 | ? | |
| 1921 | W | Montevideo HS (MN) | 53 | Marshall HS (MN) | 0 | ? | |
| 1921 | W | Montevideo HS (MN) | 80 | Ortonville HS (MN) | 0 | ? | |
| 1921 | W | Montevideo HS (MN) | 41 | Redwood Falls HS (MN) | 0 | ? | |
| 1921 | W | Montevideo HS (MN) | 7 | Willman HS (MN) | 6 | ? | |
| 1921 | W | Montevideo HS (MN) | 7 | Willmar HS (MN) | 6 | ? | |
| 1921 | L | Montgomery Bell Academy (TN) | 6 | Baylor Military Academy (TN) | 34 | ? | |
| 1921 | L | Montgomery Bell Academy (TN) | 0 | Nashville Hume-Fogg HS (TN) | 51 | ? | |
| 1921 | L | Montgomery HS (AL) | 0 | Jacksonville Duval HS (FL) | 34 | ? | |
| 1921 | L | Montgomery Sidney Lanier HS (AL) | 9 | Atlanta Boy's HS (GA) | 10 | ? | |
| 1921 | W | Montgomery Sidney Lanier HS (AL) | 62 | Troy (AL) | 0 | Montgomery, AL | |
| 1921 | L | Monticello HS (MN) | 0 | Anoka HS (MN) | 108 | ? | |
| 1921 | L | Montpelier Seminary (VT) | 0 | Colby Academy (NH) | 45 | ? | |
| 1921 | L | Montrose HS (CO) | 0 | Gunnison HS (CO) | 76 | ? | |
| 1921 | L | Montrose HS (CO) | 0 | Olathe HS (CO) | 37 | ? | |
| 1921 | W | Moorestown Friends School (NJ) | 31 | Bordentown Manual Training (NJ) | 0 | ? | |
| 1921 | L | Moorestown Friends School (NJ) | 7 | Burlington HS (NJ) | 13 | ? | |
| 1921 | W | Moorestown Friends School (NJ) | 75 | Merchantville HS (NJ) | 0 | ? | |
| 1921 | L | Moorestown Friends School (NJ) | 6 | Mount Holly HS (NJ) | 14 | ? | |
| 1921 | L | Moorestown Friends School (NJ) | 14 | Palmyra HS (NJ) | 21 | ? | |
| 1921 | W | Moorestown HS (NJ) | 22 | Ambler HS (PA) | 0 | ? | |
| 1921 | W | Moorestown HS (NJ) | 55 | Bordentown Manual Training (NJ) | 0 | ? | |
| 1921 | W | Moorestown HS (NJ) | 21 | Burlington HS (NJ) | 0 | ? | |
| 1921 | L | Moorestown HS (NJ) | 0 | Collingswood HS (NJ) | 14 | ? | |
| 1921 | W | Moorestown HS (NJ) | 14 | Gloucester HS (MA) | 7 | ? | |
| 1921 | L | Moorestown HS (NJ) | 0 | Hammonton HS (NJ) | 34 | ? | |
| 1921 | W | Moorestown HS (NJ) | 78 | Merchantville HS (NJ) | 0 | ? | |
| 1921 | W | Moorestown HS (NJ) | 14 | Millville HS (NJ) | 0 | ? | |
| 1921 | W | Moorestown HS (NJ) | 13 | Mount Holly HS (NJ) | 0 | ? | |
| 1921 | W | Moorestown HS (NJ) | 34 | Mount Holly HS (NJ) | 23 | ? | |
| 1921 | T | Moorestown HS (NJ) | 0 | Vineland HS (NJ) | 0 | ? | |
| 1921 | L | Moorhead Agriculture (MS) | 21 | Clarksdale HS (MS) | 26 | ? | |
| 1921 | W | Moorhead HS (MN) | 21 | Ada HS (MN) | 7 | ? | |
| 1921 | L | Moorhead HS (MN) | 0 | Alexandria HS (MN) | 46 | ? | |
| 1921 | W | Moorhead HS (MN) | 25 | Casselton HS (ND) | 0 | ? | |
| 1921 | W | Moorhead HS (MN) | 45 | Detroit HS (MN) | 0 | ? | |
| 1921 | L | Moorhead HS (MN) | 0 | Fargo HS (ND) | 3 | ? | |
| 1921 | W | Moorhead HS (MN) | 29 | Fergus Falls HS (MN) | 0 | ? | |
| 1921 | W | Moorhead HS (MN) | 69 | Hillsboro HS (ND) | 0 | ? | |
| 1921 | W | Moorhead HS (MN) | 26 | Wahpeton HS (ND) | 0 | ? | |
| 1921 | W | Moorhead St. (MN) | 7 | North Dakota Science | 0 | ? | |
| 1921 | L | Moorhead St. (MN) | 0 | North Dakota St. | 35 | Fargo, ND | |
| 1921 | W | Moorhead St. (MN) | 21 | Saint Cloud St. (MN) | 0 | ? | |
| 1921 | L | Moorhead St. (MN) | 6 | Valley City St. (ND) | 7 | ? | |
| 1921 | L | Moorhead St. (MN) | 9 | Fargo College (ND) | 19 | Moorhead, MN | |
| 1921 | W | Moorhead St. (MN) | 18 | Concordia-Moorhead (MN) | 6 | Moorhead, MN | |
| 1921 | W | Mooseheart HS (IL) | 14 | Aurora East HS (IL) | 7 | ? | |
| 1921 | W | Mooseheart HS (IL) | 6 | Aurora West HS (IL) | 0 | ? | |
| 1921 | W | Mooseheart HS (IL) | 75 | Batavia HS (IL) | 0 | ? | |
| 1921 | L | Mooseheart HS (IL) | 7 | Chicago Englewood HS (IL) | 13 | ? | |
| 1921 | W | Mooseheart HS (IL) | 49 | Dundee HS (IL) | 0 | ? | |
| 1921 | W | Mooseheart HS (IL) | 55 | Harrison Tech | 0 | ? | |
| 1921 | W | Mooseheart HS (IL) | 60 | Benedictine (IL) | 0 | Mooseheart, IL | |
| 1921 | L | Moravian Prep | 7 | Harrisburg Tech HS (PA) | 14 | ? | |
| 1921 | L | Moravian Prep | 0 | Peddie Institute (NJ) | 14 | ? | |
| 1921 | T | Moravian Prep | 7 | West Chester (PA) | 7 | West Chester, PA | |
| 1921 | W | Morehouse (GA) | 41 | 24th Infantry (GA) | 18 | ? | |
| 1921 | W | Morehouse (GA) | 7 | Atlanta (GA) | 0 | ? | |
| 1921 | W | Morehouse (GA) | 6 | Fisk (TN) | 0 | ? | |
| 1921 | W | Morehouse (GA) | 41 | Johnson C. Smith (NC) | 0 | ? | |
| 1921 | W | Morehouse (GA) | 13 | Knoxville (TN) | 0 | ? | |
| 1921 | W | Morehouse (GA) | 7 | Morris Brown (GA) | 0 | ? | |
| 1921 | L | Morenci HS (MI) | 0 | Tecumseh HS (MI) | 6 | ? | |
| 1921 | T | Morgan City HS (LA) | 0 | Baton Rouge HS (LA) | 0 | ? | |
| 1921 | W | Morgan HS | 27 | Nashville Hume-Fogg HS (TN) | 0 | ? | |
| 1921 | L | Morgan Park HS (MN) | 7 | Duluth Cathedral HS (MN) | 62 | ? | |
| 1921 | L | Morgan Park HS (MN) | 7 | Duluth Denfeld HS (MN) | 99 | ? | |
| 1921 | T | Morgan Park Military Academy (IL) | 0 | Chicago Bowen HS (IL) | 0 | ? | |
| 1921 | W | Morgan Prep School (TN) | 54 | Bryson (TN) | 0 | Fayetteville, TN | |
| 1921 | L | Morgan St. (MD) | 0 | Harrisburg YMCA (PA) | 52 | Harrisburg, PA | |
| 1921 | L | Morgan St. (MD) | 0 | Lincoln (PA) | 63 | Baltimore, MD | |
| 1921 | L | Morgan St. (MD) | 0 | Virginia Union | 85 | Richmond, VA | |
| 1921 | L | Morgan St. (MD) | 0 | Storer College (WV) | 25 | Baltimore, MD | |
| 1921 | W | Morganfield HS (KY) | 42 | Clay HS (KY) | 6 | ? | |
| 1921 | W | Morganfield HS (KY) | 7 | Greenville HS (KY) | 0 | ? | |
| 1921 | T | Morganfield HS (KY) | 0 | Madisonville HS (KY) | 0 | ? | |
| 1921 | W | Morganfield HS (KY) | 7 | Madisonville HS (KY) | 6 | ? | |
| 1921 | W | Morganfield HS (KY) | 20 | Marion HS (KY) | 0 | ? | |
| 1921 | W | Morganfield HS (KY) | 14 | Mayfield HS (KY) | 0 | ? | |
| 1921 | W | Morganfield HS (KY) | 21 | Mount Vernon HS (IN) | 0 | ? | |
| 1921 | W | Morganfield HS (KY) | 7 | Sturgis HS (KY) | 6 | ? | |
| 1921 | L | Morganfield HS (KY) | 0 | Winchester HS (KY) | 16 | ? | |
| 1921 | L | Morgantown HS (WV) | 0 | Buckhannon HS (WV) | 35 | ? | |
| 1921 | W | Morgantown HS (WV) | 8 | Fairmont East Side HS (WV) | 6 | ? | |
| 1921 | L | Morgantown HS (WV) | 0 | Fairmont HS (WV) | 7 | ? | |
| 1921 | W | Morgantown HS (WV) | 19 | Fairmont HS (WV) | 7 | ? | |
| 1921 | T | Morgantown HS (WV) | 14 | Grafton HS (WV) | 14 | ? | |
| 1921 | W | Morgantown HS (WV) | 34 | Kingwood HS | 7 | ? | |
| 1921 | L | Morgantown HS (WV) | 7 | Pennsboro HS (WV) | 24 | ? | |
| 1921 | L | Morgantown HS (WV) | 0 | Pittsburgh Allegheny HS (PA) | 7 | ? | |
| 1921 | W | Morgantown HS (WV) | 24 | Shinnston HS (WV) | 0 | ? | |
| 1921 | L | Morgantown HS (WV) | 0 | Uniontown HS (PA) | 16 | ? | |
| 1921 | W | Morgantown HS (WV) | 14 | Waynesburg HS (PA) | 7 | ? | |
| 1921 | L | Morgantown HS (WV) | 0 | Weston HS (WV) | 21 | ? | |
| 1921 | W | Morningside (IA) | 9 | Buena Vista (IA) | 0 | ? | Game in question |
| 1921 | W | Morningside (IA) | 14 | Des Moines (IA) | 0 | Sioux City, IA | |
| 1921 | W | Morningside (IA) | 27 | Upper Iowa | 0 | Sioux City, IA | |
| 1921 | W | Morningside (IA) | 49 | Wayne St. (NE) | 0 | ? | |
| 1921 | L | Morningside (IA) | 6 | Yankton (SD) | 7 | Yankton, SD | |
| 1921 | W | Morningside (IA) | 9 | Westmar (IA) | 0 | Sioux City, IA | |
| 1921 | W | Morningside (IA) | 31 | Nebraska Wesleyan | 7 | Lincoln, NE | |
| 1921 | L | Morningside (IA) | 10 | Drake (IA) | 30 | Des Moines, IA | |
| 1921 | L | Morrilton HS (AR) | 6 | Russellville HS (AR) | 57 | ? | |
| 1921 | L | Morris (SC) | 0 | South Carolina St. | 14 | Orangeburg, SC | |
| 1921 | T | Morris Brown (GA) | 0 | 24th Infantry (GA) | 0 | ? | |
| 1921 | W | Morris Brown (GA) | 19 | Atlanta (GA) | 7 | ? | |
| 1921 | L | Morris Brown (GA) | 0 | Morehouse (GA) | 7 | ? | |
| 1921 | L | Morris Brown (GA) | 13 | Talladega (AL) | 23 | ? | |
| 1921 | T | Morris Brown (GA) | 13 | Tuskegee (AL) | 13 | ? | |
| 1921 | L | Morristown HS (NJ) | 0 | Bethlehem HS (PA) | 14 | ? | |
| 1921 | L | Morristown HS (NJ) | 0 | Carlton Academy (NJ) | 28 | ? | |
| 1921 | L | Morristown HS (NJ) | 0 | Hackley School (NY) | 33 | ? | |
| 1921 | L | Morristown HS (NJ) | 0 | La Salle Prep School (PA) | 14 | ? | |
| 1921 | L | Morristown HS (NJ) | 21 | Pingry School (NJ) | 41 | ? | |
| 1921 | L | Morristown HS (NJ) | 13 | Summit HS (NJ) | 14 | ? | |
| 1921 | T | Morristown School (NJ) | 21 | Newark Academy (NJ) | 21 | ? | |
| 1921 | L | Morrisville HS (PA) | 7 | Bristol HS (PA) | 81 | ? | |
| 1921 | L | Morton HS (IL) | 0 | Proviso Township HS (IL) | 57 | ? | |
| 1921 | L | Moultrie HS (GA) | 0 | Jacksonville Duval HS (FL) | 44 | ? | |
| 1921 | L | Mounds Legion | 0 | Sapulpa HS (OK) | 73 | ? | |
| 1921 | W | Moundsville HS (WV) | 20 | Cameron HS (WV) | 0 | ? | |
| 1921 | L | Moundsville HS (WV) | 0 | Follansbee HS (WV) | 27 | ? | |
| 1921 | L | Moundsville HS (WV) | 3 | Parkersburg HS (WV) | 53 | ? | |
| 1921 | W | Moundsville HS (WV) | 24 | Richland District HS (WV) | 0 | ? | |
| 1921 | W | Moundsville HS (WV) | 53 | Sistersville HS (WV) | 0 | ? | |
| 1921 | L | Moundsville HS (WV) | 0 | Spencer HS (WV) | 7 | ? | |
| 1921 | L | Moundsville HS (WV) | 0 | Triadelphia HS (WV) | 6 | ? | |
| 1921 | L | Mount Angel (OR) | 6 | Pacific (OR) | 20 | ? | |
| 1921 | L | Mount Blanchard HS (OH) | 0 | Arlington HS (OH) | 14 | ? | |
| 1921 | W | Mount Blanchard HS (OH) | 10 | Carey HS (OH) | 7 | ? | |
| 1921 | W | Mount Blanchard HS (OH) | 7 | Carey HS (OH) | 6 | ? | |
| 1921 | W | Mount Blanchard HS (OH) | 23 | Findlay JV (OH) | 0 | ? | |
| 1921 | T | Mount Blanchard HS (OH) | 12 | Mount Blanchard HS Alumni (OH) | 12 | ? | |
| 1921 | L | Mount Blanchard HS (OH) | 0 | Mount Cory HS (OH) | 13 | ? | |
| 1921 | T | Mount Blanchard HS (OH) | 0 | Rawson HS (OH) | 0 | ? | |
| 1921 | W | Mount Blanchard HS (OH) | 13 | Vanlue HS (OH) | 0 | ? | |
| 1921 | W | Mount Blanchard HS (OH) | 10 | Vanlue HS (OH) | 0 | ? | |
| 1921 | T | Mount Blanchard HS Alumni (OH) | 12 | Mount Blanchard HS (OH) | 12 | ? | |
| 1921 | W | Mount Carmel HS (PA) | 47 | Centralia | 0 | ? | |
| 1921 | L | Mount Carmel HS (PA) | 0 | Harrisburg Tech HS (PA) | 12 | ? | |
| 1921 | W | Mount Carmel HS (PA) | 47 | Hazleton HS (PA) | 0 | ? | |
| 1921 | L | Mount Carmel HS (PA) | 7 | Lancaster HS (PA) | 35 | ? | |
| 1921 | W | Mount Carmel HS (PA) | 6 | Lock Haven HS (PA) | 0 | ? | |
| 1921 | W | Mount Carmel HS (PA) | 5 | Mahanoy City HS (PA) | 0 | ? | |
| 1921 | W | Mount Carmel HS (PA) | 61 | Minersville HS (PA) | 0 | ? | |
| 1921 | W | Mount Carmel HS (PA) | 71 | Shamokin HS (PA) | 0 | ? | |
| 1921 | W | Mount Carmel HS (PA) | 66 | Shenandoah HS (PA) | 0 | ? | |
| 1921 | T | Mount Carmel HS (PA) | 7 | Steelton HS (PA) | 7 | ? | |
| 1921 | T | Mount Clemens HS (MI) | 0 | Detroit Northeastern HS (MI) | 0 | ? | |
| 1921 | W | Mount Cory HS (OH) | 19 | Ada HS (OH) | 0 | ? | |
| 1921 | W | Mount Cory HS (OH) | 9 | Arlington HS (OH) | 6 | ? | |
| 1921 | W | Mount Cory HS (OH) | 9 | Kenton HS (OH) | 0 | ? | |
| 1921 | W | Mount Cory HS (OH) | 44 | Leipsic HS (OH) | 0 | ? | |
| 1921 | W | Mount Cory HS (OH) | 21 | McComb HS (OH) | 20 | ? | |
| 1921 | W | Mount Cory HS (OH) | 13 | Mount Blanchard HS (OH) | 0 | ? | |
| 1921 | W | Mount Cory HS (OH) | 72 | Van Buren HS (OH) | 0 | ? | |
| 1921 | W | Mount Cory HS (OH) | 20 | Van Buren HS (OH) | 6 | ? | |
| 1921 | W | Mount Diablo HS (CA) | 21 | Alhambra HS (CA) | 6 | ? | |
| 1921 | W | Mount Diablo HS (CA) | 19 | Antioch HS (CA) | 6 | ? | |
| 1921 | W | Mount Diablo HS (CA) | 28 | California Institute for the Deaf | 0 | ? | |
| 1921 | W | Mount Diablo HS (CA) | 76 | De La Rosas HS | 0 | ? | |
| 1921 | L | Mount Diablo HS (CA) | 7 | Livermore HS (CA) | 31 | ? | |
| 1921 | L | Mount Diablo HS (CA) | 14 | Livermore HS (CA) | 28 | ? | |
| 1921 | L | Mount Diablo HS (CA) | 0 | Napa HS (CA) | 19 | ? | |
| 1921 | L | Mount Diablo HS (CA) | 0 | Richmond HS (CA) | 45 | ? | |
| 1921 | W | Mount Diablo HS (CA) | 13 | Vallejo Moose HS | 0 | ? | |
| 1921 | L | Mount Gilead HS (OH) | 7 | Richmond HS (OH) | 18 | ? | |
| 1921 | W | Mount Holly HS (NJ) | 14 | Burlington HS (NJ) | 0 | ? | |
| 1921 | L | Mount Holly HS (NJ) | 7 | Lakewood HS (NJ) | 21 | ? | |
| 1921 | W | Mount Holly HS (NJ) | 14 | Moorestown Friends School (NJ) | 6 | ? | |
| 1921 | L | Mount Holly HS (NJ) | 0 | Moorestown HS (NJ) | 13 | ? | |
| 1921 | L | Mount Holly HS (NJ) | 23 | Moorestown HS (NJ) | 34 | ? | |
| 1921 | L | Mount Holly HS (NJ) | 14 | Palmyra HS (NJ) | 21 | ? | |
| 1921 | L | Mount Holly HS (NJ) | 0 | Palmyra HS (NJ) | 18 | ? | |
| 1921 | L | Mount Morris (IL) | 0 | Loras (IA) | 42 | Dubuque, IA | |
| 1921 | L | Mount Morris (IL) | 9 | Northern Illinois | 62 | DeKalb, IL | |
| 1921 | L | Mount Morris (IL) | 6 | Wheaton (IL) | 7 | Mount Morris, IL | |
| 1921 | L | Mount Pleasant HS (IA) | 0 | Keokuk HS (IA) | 7 | ? | |
| 1921 | L | Mount Pleasant HS (MI) | 0 | Ferris St. (MI) | 7 | Big Rapids, MI | |
| 1921 | W | Mount Pleasant HS (NY) | 19 | Barnard School (NY) | 7 | ? | |
| 1921 | L | Mount Pleasant HS (NY) | 0 | Horace Mann School (NY) | 14 | ? | |
| 1921 | L | Mount Pleasant Military Academy (NY) | 7 | Peekskill Military Academy (NY) | 25 | ? | |
| 1921 | L | Mount Saint Joseph's College (MD) | 0 | Annapolis HS (MD) | 6 | ? | |
| 1921 | W | Mount Saint Joseph's College (MD) | 3 | Army & Navy Prep School (DC) | 0 | ? | |
| 1921 | W | Mount Saint Joseph's College (MD) | 7 | Baltimore City College (MD) | 0 | ? | |
| 1921 | W | Mount Saint Joseph's College (MD) | 41 | Calvert Hall | 0 | ? | |
| 1921 | L | Mount Saint Joseph's College (MD) | 0 | Gilman Country School (MD) | 40 | ? | |
| 1921 | W | Mount Saint Joseph's College (MD) | 17 | McDonogh School (MD) | 0 | ? | |
| 1921 | L | Mount Saint Joseph's College (MD) | 0 | Severn School (MD) | 14 | ? | |
| 1921 | L | Mount Saint Mary's (MD) | 0 | Catholic (DC) | 7 | Washington, DC | |
| 1921 | L | Mount Saint Mary's (MD) | 0 | Gettysburg (PA) | 28 | Gettysburg, PA | |
| 1921 | W | Mount Saint Mary's (MD) | 21 | McDaniel College (MD) | 0 | Westminster, MD | |
| 1921 | L | Mount Saint Mary's (MD) | 0 | Villanova (PA) | 7 | Villanova, PA | |
| 1921 | L | Mount Saint Mary's (MD) | 2 | Johns Hopkins (MD) | 3 | Baltimore, MD | |
| 1921 | W | Mount Saint Mary's (MD) | 27 | Davis & Elkins (WV) | 0 | Emmitsburg, MD | |
| 1921 | T | Mount Saint Mary's (MD) | 0 | Susquehanna (PA) | 0 | Selinsgrove, PA | |
| 1921 | W | Mount Saint Mary's (MD) | 6 | Saint John's (MD) | 0 | Emmitsburg, MD | |
| 1921 | L | Mount Saint Mary's Prep | 0 | Army & Navy Prep School (DC) | 6 | ? | |
| 1921 | L | Mount Union (OH) | 14 | Akron (OH) | 28 | Akron, OH | |
| 1921 | W | Mount Union (OH) | 35 | Canton McKinley HS (OH) | 7 | Alliance, OH | |
| 1921 | T | Mount Union (OH) | 0 | Kenyon (OH) | 0 | Alliance, OH | |
| 1921 | L | Mount Union (OH) | 0 | Oberlin (OH) | 13 | Alliance, OH | |
| 1921 | L | Mount Union (OH) | 0 | Wooster (OH) | 6 | Alliance, OH | |
| 1921 | L | Mount Union (OH) | 0 | Michigan | 44 | Ann Arbor, MI | |
| 1921 | L | Mount Union (OH) | 7 | Case Institute of Technology (OH) | 13 | Alliance, OH | |
| 1921 | L | Mount Union (OH) | 0 | Miami (OH) | 29 | Alliance, OH | |
| 1921 | W | Mount Union HS (PA) | 21 | Clearfield HS (PA) | 14 | ? | |
| 1921 | L | Mount Union HS (PA) | 0 | Johnstown HS (PA) | 67 | ? | |
| 1921 | L | Mount Vernon HS (MO) | 0 | Joplin HS (MO) | 38 | ? | |
| 1921 | W | Mount Vernon HS (NY) | 20 | Brooklyn Manual Training HS (NY) | 2 | ? | |
| 1921 | W | Mount Vernon HS (NY) | 14 | Concordia Prep School (NY) | 9 | ? | |
| 1921 | L | Mount Vernon HS (NY) | 7 | Flushing HS (NY) | 12 | ? | |
| 1921 | W | Mount Vernon HS (NY) | 41 | Mamaroneck HS (NY) | 6 | ? | |
| 1921 | W | Mount Vernon HS (NY) | 20 | New Rochelle HS (NY) | 7 | ? | |
| 1921 | W | Mount Vernon HS (NY) | 19 | Stamford HS (CT) | 10 | ? | |
| 1921 | W | Mount Vernon HS (NY) | 21 | Yonkers HS (NY) | 6 | ? | |
| 1921 | L | Mount Vernon HS (OH) | 6 | Canton McKinley HS (OH) | 48 | ? | |
| 1921 | L | Mount Vernon HS (OH) | 0 | Toledo Scott HS (OH) | 87 | ? | |
| 1921 | L | Mount Vernon HS (WA) | 7 | Everett HS (WA) | 74 | ? | |
| 1921 | W | Mount Vernon HS JV (NY) | 12 | Bronxville HS (NY) | 7 | ? | |
| 1921 | L | Mountain Iron HS (MN) | 0 | Aurora HS (MN) | 24 | ? | |
| 1921 | L | Mountain Iron HS (MN) | 0 | Coleraine HS (MN) | 82 | ? | |
| 1921 | W | Mountain View HS (CA) | 34 | Mountain View HS Alumni (CA) | 0 | ? | |
| 1921 | L | Mountain View HS (CA) | 0 | Palo Alto HS (CA) | 7 | ? | |
| 1921 | W | Mountain View HS (CA) | 26 | Redwood City HS (CA) | 7 | ? | |
| 1921 | W | Mountain View HS (CA) | 2 | San Francisco South HS (CA) | 0 | ? | |
| 1921 | L | Mountain View HS (CA) | 0 | San Jose HS (CA) | 35 | ? | |
| 1921 | W | Mountain View HS (CA) | 7 | San Mateo HS (CA) | 0 | ? | |
| 1921 | W | Mountain View HS (CA) | 24 | Santa Clara HS (CA) | 0 | ? | |
| 1921 | W | Mountain View HS (CA) | 27 | William Warren Military School (CA) | 0 | ? | |
| 1921 | L | Mountain View HS Alumni (CA) | 0 | Mountain View HS (CA) | 34 | ? | |
| 1921 | W | Muhlenberg (PA) | 15 | Albright (PA) | 7 | Myerstown, PA | |
| 1921 | W | Muhlenberg (PA) | 17 | Gettysburg (PA) | 13 | Gettysburg, PA | |
| 1921 | L | Muhlenberg (PA) | 0 | Lafayette (PA) | 48 | Easton, PA | |
| 1921 | T | Muhlenberg (PA) | 21 | Lebanon Valley (PA) | 21 | Allentown, PA | |
| 1921 | W | Muhlenberg (PA) | 7 | Swarthmore (PA) | 6 | Allentown, PA | |
| 1921 | W | Muhlenberg (PA) | 68 | Ursinus (PA) | 0 | Allentown, PA | |
| 1921 | W | Muhlenberg (PA) | 21 | Delaware | 0 | Newark, DE | |
| 1921 | W | Muhlenberg (PA) | 14 | Lehigh (PA) | 13 | Allentown, PA | |
| 1921 | L | Muhlenberg (PA) | 0 | Bucknell (PA) | 14 | Allentown, PA | |
| 1921 | W | Muhlenberg (PA) | 12 | Fordham (NY) | 7 | Allentown, PA | |
| 1921 | L | Muhlenberg Freshmen (PA) | 0 | Allentown Prep School (PA) | 14 | ? | |
| 1921 | L | Mukwonago HS (WI) | 0 | Milwaukee South Division HS (WI) | 67 | ? | |
| 1921 | T | Mullens American Legion (WV) | 0 | Concord (WV) | 0 | Mullins, WV | |
| 1921 | L | Mullens American Legion (WV) | 0 | West Virginia Tech | 28 | ? | |
| 1921 | W | Multnomah AC (OR) | 18 | Whitman (WA) | 6 | Portland, OR | |
| 1921 | W | Multnomah AC (OR) | 21 | Gonzaga (WA) | 7 | Portland, OR | |
| 1921 | T | Multnomah AC (OR) | 7 | Oregon St. | 7 | Corvallis, OR | |
| 1921 | L | Multnomah AC (OR) | 7 | Oregon | 21 | Eugene, OR | |
| 1921 | W | Munhall HS (PA) | 14 | Ben Avon HS (PA) | 0 | ? | |
| 1921 | L | Munhall HS (PA) | 0 | Duquesne HS (PA) | 35 | ? | |
| 1921 | L | Munhall HS (PA) | 6 | North Braddock HS (PA) | 15 | ? | |
| 1921 | W | Murphy College (TN) | 35 | East Tennessee St. | 0 | ? | |
| 1921 | W | Murphysboro HS (IL) | 48 | Anna HS (IL) | 0 | ? | |
| 1921 | W | Murphysboro HS (IL) | 35 | Benton HS (IL) | 13 | ? | |
| 1921 | W | Murphysboro HS (IL) | 28 | Cairo HS (IL) | 13 | ? | |
| 1921 | W | Murphysboro HS (IL) | 124 | Carbondale HS (IL) | 7 | ? | |
| 1921 | W | Murphysboro HS (IL) | 68 | Carbondale HS (IL) | 3 | ? | |
| 1921 | W | Murphysboro HS (IL) | 65 | Eldorado HS (IL) | 0 | ? | |
| 1921 | W | Murphysboro HS (IL) | 19 | Frankfort West HS (IL) | 13 | ? | |
| 1921 | W | Murphysboro HS (IL) | 27 | Harrisburg HS (IL) | 6 | ? | |
| 1921 | W | Murphysboro HS (IL) | 20 | Harrisburg HS (IL) | 17 | ? | |
| 1921 | W | Murphysboro HS (IL) | 39 | Johnson City HS | 0 | ? | |
| 1921 | W | Murphysboro HS (IL) | 41 | Marion HS (IL) | 0 | ? | |
| 1921 | L | Murray City HS (OH) | 0 | Rio Grande (OH) | 58 | ? | |
| 1921 | L | Murray St. (OK) | 0 | Southeastern Oklahoma St. | 34 | ? | |
| 1921 | W | Muskegon HS (MI) | 27 | Benton Harbor HS (MI) | 14 | ? | |
| 1921 | W | Muskegon HS (MI) | 48 | Detroit Eastern HS (MI) | 0 | ? | |
| 1921 | W | Muskegon HS (MI) | 28 | Grand Haven HS (MI) | 0 | ? | |
| 1921 | W | Muskegon HS (MI) | 14 | Grand Rapids Central HS (MI) | 0 | ? | |
| 1921 | W | Muskegon HS (MI) | 42 | Grand Rapids South HS (MI) | 0 | ? | |
| 1921 | W | Muskegon HS (MI) | 34 | Grand Rapids Union HS (MI) | 0 | ? | |
| 1921 | W | Muskegon HS (MI) | 20 | Kalamazoo HS (MI) | 0 | ? | |
| 1921 | W | Muskegon HS (MI) | 79 | Traverse City HS (MI) | 0 | ? | |
| 1921 | T | Muskingum (OH) | 0 | Baldwin-Wallace (OH) | 0 | New Concord, OH | |
| 1921 | W | Muskingum (OH) | 30 | Dayton (OH) | 14 | New Concord, OH | |
| 1921 | W | Muskingum (OH) | 27 | Rio Grande (OH) | 14 | New Concord, OH | |
| 1921 | L | Muskingum (OH) | 0 | Wilmington (OH) | 32 | New Concord, OH | |
| 1921 | L | Muskingum (OH) | 6 | Wittenberg (OH) | 28 | Springfield, OH | |
| 1921 | W | Muskingum (OH) | 34 | Defiance (OH) | 0 | New Concord, OH | |
| 1921 | L | Muskingum (OH) | 8 | Akron (OH) | 35 | Akron, OH | |
| 1921 | T | Muskingum (OH) | 7 | Kenyon (OH) | 7 | Gambier, OH | |
| 1921 | W | Muskingum (OH) | 9 | Earlham (IN) | 7 | Richmond, IN | |
| 1921 | L | Muskogee Central HS (OK) | 7 | Little Rock HS (AR) | 14 | ? | |
| 1921 | W | Muskogee HS (OK) | 21 | Joplin HS (MO) | 6 | ? | |
| 1921 | L | Myers Bears | 0 | Dubuque (IA) | 7 | Dubuque, IA | |
| 1921 | T | Nanticoke HS (PA) | 0 | Wilkes-Barre HS (PA) | 0 | ? | |
| 1921 | L | Narberth HS (PA) | 0 | Abington HS (PA) | 34 | ? | |
| 1921 | W | Narberth HS (PA) | 6 | Haddon Heights HS (NJ) | 3 | ? | |
| 1921 | L | Narberth HS (PA) | 0 | Lower Merion HS (PA) | 14 | ? | |
| 1921 | L | Narberth HS (PA) | 0 | Norristown HS (PA) | 66 | ? | |
| 1921 | L | Nashua HS | 0 | Woburn HS (MA) | 14 | ? | |
| 1921 | L | Nashua HS (NH) | 0 | Framingham HS (MA) | 26 | ? | |
| 1921 | L | Nashua HS (NH) | 0 | Manchester HS (NH) | 28 | ? | |
| 1921 | L | Nashville Central HS (TN) | 0 | Baylor Military Academy (TN) | 21 | ? | |
| 1921 | W | Nashville Hume-Fogg HS (TN) | 14 | Clarksville HS (TN) | 0 | ? | |
| 1921 | W | Nashville Hume-Fogg HS (TN) | 52 | Columbia HS (TN) | 0 | ? | |
| 1921 | T | Nashville Hume-Fogg HS (TN) | 0 | Massey Military Academy (TN) | 0 | ? | |
| 1921 | W | Nashville Hume-Fogg HS (TN) | 51 | Montgomery Bell Academy (TN) | 0 | ? | |
| 1921 | L | Nashville Hume-Fogg HS (TN) | 0 | Morgan HS | 27 | ? | |
| 1921 | W | Nashville Hume-Fogg HS (TN) | 20 | Peabody HS | 0 | ? | |
| 1921 | W | Nashville Hume-Fogg HS (TN) | 77 | Wallace University School | 6 | ? | |
| 1921 | W | Nashville Hume-Fogg HS (TN) | 10 | Castle Heights Military Institute (TN) | 0 | Nashville, TN | |
| 1921 | L | Nashville Pearl HS (TN) | 0 | Roger Williams (TN) | 12 | ? | |
| 1921 | L | Natchitoches HS (LA) | 0 | Northwestern St. (LA) | 14 | Natchitoches, LA | |
| 1921 | W | Natick HS (MA) | 13 | Concord HS (MA) | 6 | ? | |
| 1921 | L | Natick HS (MA) | 6 | Framingham HS (MA) | 10 | ? | |
| 1921 | W | Natick HS (MA) | 32 | Hudson HS (MA) | 3 | ? | |
| 1921 | W | Natick HS (MA) | 46 | Marlboro HS (VT) | 7 | ? | |
| 1921 | W | Natick HS (MA) | 7 | Milford HS (MA) | 0 | ? | |
| 1921 | L | Natick HS (MA) | 14 | Needham HS (MA) | 20 | ? | |
| 1921 | W | Natick HS (MA) | 6 | Providence Tech HS (RI) | 0 | ? | |
| 1921 | L | Natick HS (MA) | 6 | Quincy HS (MA) | 7 | ? | |
| 1921 | L | Natick HS (MA) | 0 | Waltham HS (MA) | 12 | ? | |
| 1921 | W | Natick HS (MA) | 2 | Worcester Trade (MA) | 0 | ? | |
| 1921 | T | Naugatuck | 0 | Ansonia HS (CT) | 0 | ? | |
| 1921 | W | Naugatuck HS (CT) | 7 | Crosby HS (CT) | 0 | ? | |
| 1921 | W | Naugatuck HS (CT) | 10 | Torrington HS (CT) | 0 | ? | |
| 1921 | L | Naval Gun. Fac. | 0 | Washington Dunbar HS (DC) | 6 | ? | |
| 1921 | W | Navy (MD) | 7 | Army (NY) | 0 | New York, NY | |
| 1921 | W | Navy (MD) | 21 | Bethany (WV) | 0 | Annapolis, MD | |
| 1921 | W | Navy (MD) | 13 | Princeton (NJ) | 0 | Annapolis, MD | |
| 1921 | W | Navy (MD) | 40 | North Carolina St. | 0 | Annapolis, MD | |
| 1921 | W | Navy (MD) | 6 | Bucknell (PA) | 0 | Annapolis, MD | |
| 1921 | W | Navy (MD) | 53 | Western Reserve (OH) | 0 | Annapolis, MD | |
| 1921 | L | Navy (MD) | 7 | Penn St. | 13 | Philadelphia, PA | |
| 1921 | W | Navy Freshmen (MD) | 9 | Staunton Military Academy (VA) | 7 | ? | |
| 1921 | W | Navy Freshmen (MD) | 40 | Williamson Trade School (PA) | 0 | ? | |
| 1921 | L | Nazareth Hall Military Academy (PA) | 0 | Quakertown HS (PA) | 98 | ? | |
| 1921 | W | Nebraska | 70 | Colorado St. | 7 | Lincoln, NE | |
| 1921 | W | Nebraska | 41 | Haskell Indian Nations (KS) | 0 | Lincoln, NE | |
| 1921 | W | Nebraska | 35 | Iowa St. | 3 | Ames, IA | |
| 1921 | L | Nebraska | 0 | Notre Dame (IN) | 7 | South Bend, IN | |
| 1921 | W | Nebraska | 44 | Oklahoma | 0 | Lincoln, NE | |
| 1921 | W | Nebraska | 55 | Nebraska Wesleyan | 0 | Lincoln, NE | |
| 1921 | W | Nebraska | 10 | Pittsburgh (PA) | 0 | Pittsburgh, PA | |
| 1921 | W | Nebraska | 28 | Kansas | 0 | Lincoln, NE | |
| 1921 | L | Nebraska Central | 0 | Doane (NE) | 33 | ? | |
| 1921 | L | Nebraska Central | 6 | Hastings (NE) | 21 | ? | |
| 1921 | L | Nebraska Central | 6 | Midland Lutheran (NE) | 26 | ? | |
| 1921 | L | Nebraska Central | 0 | Nebraska-Kearney | 6 | ? | |
| 1921 | L | Nebraska Central | 12 | Wayne St. (NE) | 47 | ? | |
| 1921 | L | Nebraska School of Agriculture | 0 | Cambridge HS (NE) | 34 | ? | |
| 1921 | W | Nebraska School of Agriculture | 40 | Cozad HS (NE) | 0 | ? | |
| 1921 | W | Nebraska School of Agriculture | 20 | Gothenburg HS (NE) | 6 | ? | |
| 1921 | W | Nebraska School of Agriculture | 36 | Holdrege HS (NE) | 0 | ? | |
| 1921 | W | Nebraska School of Agriculture | 103 | Holyoke HS (CO) | 0 | ? | |
| 1921 | W | Nebraska School of Agriculture | 27 | Lexington HS (NE) | 2 | ? | |
| 1921 | W | Nebraska School of Agriculture | 93 | Maxwell HS (NE) | 0 | ? | |
| 1921 | W | Nebraska School of Agriculture | 10 | McCook HS (NE) | 0 | ? | |
| 1921 | L | Nebraska School of Agriculture | 10 | North Platte HS (NE) | 14 | ? | |
| 1921 | W | Nebraska Wesleyan | 14 | Benedictine (KS) | 12 | ? | |
| 1921 | W | Nebraska Wesleyan | 20 | Chadron St. (NE) | 10 | Lincoln, NE | |
| 1921 | L | Nebraska Wesleyan | 3 | Denver (CO) | 21 | Denver, CO | |
| 1921 | W | Nebraska Wesleyan | 3 | Doane (NE) | 0 | Crete, NE | |
| 1921 | W | Nebraska Wesleyan | 14 | Hastings (NE) | 0 | Hastings, NE | |
| 1921 | W | Nebraska Wesleyan | 17 | York (NE) | 0 | Lincoln, NE | |
| 1921 | L | Nebraska Wesleyan | 0 | Nebraska | 55 | Lincoln, NE | |
| 1921 | W | Nebraska Wesleyan | 17 | Wayne St. (NE) | 3 | Lincoln, NE | State Championship |
| 1921 | L | Nebraska Wesleyan | 7 | Morningside (IA) | 31 | Lincoln, NE | |
| 1921 | W | Nebraska Wesleyan | 35 | Tarkio (MO) | 0 | Lincoln, NE | |
| 1921 | W | Nebraska Wesleyan | 17 | Grand Island College (NE) | 0 | Grand Island, NE | |
| 1921 | W | Nebraska-Kearney | 3 | Cotner (NE) | 0 | Bethany, NE | |
| 1921 | T | Nebraska-Kearney | 7 | Hastings (NE) | 7 | ? | |
| 1921 | L | Nebraska-Kearney | 0 | Midland Lutheran (NE) | 13 | ? | |
| 1921 | W | Nebraska-Kearney | 6 | Nebraska Central | 0 | ? | |
| 1921 | L | Nebraska-Kearney | 0 | Peru St. (NE) | 3 | ? | |
| 1921 | W | Nebraska-Kearney | 7 | Chadron St. (NE) | 6 | Chadron, NE | |
| 1921 | L | Nebraska-Omaha | 6 | Midland Lutheran (NE) | 3 | Omaha, NE | Nebraska-Omaha Forfeits |
| 1921 | W | Nebraska-Omaha | 49 | Tabor (IA) | 0 | Tabor, IA | |
| 1921 | W | Nebraska-Omaha | 14 | Tarkio (MO) | 3 | Tarkio, MO | |
| 1921 | L | Nebraska-Omaha | 0 | Trinity (IA) | 10 | Omaha, NE | |
| 1921 | T | Nebraska-Omaha | 0 | Cotner (NE) | 0 | Omaha, NE | |
| 1921 | T | Needham HS (MA) | 7 | Hudson HS (MA) | 7 | ? | |
| 1921 | W | Needham HS (MA) | 20 | Natick HS (MA) | 14 | ? | |
| 1921 | L | Needham HS (MA) | 7 | Norwood HS (MA) | 34 | ? | |
| 1921 | L | Negaunee Legion (MI) | 15 | Northern Michigan | 27 | Marquette, MI | |
| 1921 | L | Neodesha HS (KS) | 7 | Independence HS (KS) | 13 | ? | |
| 1921 | W | Neosho HS (MO) | 20 | Joplin HS (MO) | 0 | ? | |
| 1921 | W | Neptune HS (NJ) | 6 | Asbury Park HS (NJ) | 0 | ? | |
| 1921 | W | Neptune HS (NJ) | 7 | Atlantic City HS (NJ) | 0 | ? | |
| 1921 | W | Neptune HS (NJ) | 9 | Battin HS (NJ) | 6 | ? | |
| 1921 | L | Neptune HS (NJ) | 0 | East Orange HS (NJ) | 20 | ? | |
| 1921 | W | Neptune HS (NJ) | 39 | Freehold HS (NJ) | 7 | ? | |
| 1921 | T | Neptune HS (NJ) | 7 | Lakewood HS (NJ) | 7 | ? | |
| 1921 | W | Neptune HS (NJ) | 55 | Long Branch Chattle HS (NJ) | 0 | ? | |
| 1921 | W | Neptune HS (NJ) | 15 | Neptune HS Alumni (NJ) | 0 | ? | |
| 1921 | W | Neptune HS (NJ) | 7 | Trenton HS (NJ) | 0 | ? | |
| 1921 | L | Neptune HS Alumni (NJ) | 0 | Neptune HS (NJ) | 15 | ? | |
| 1921 | W | Nevada | 21 | California-Davis | 13 | Reno, NV | |
| 1921 | L | Nevada | 6 | Saint Mary's (CA) | 14 | Reno, NV | |
| 1921 | W | Nevada | 41 | Utah St. | 0 | Logan, UT | |
| 1921 | T | Nevada | 0 | Outrigger AC (HI) | 0 | Honolulu, HI | |
| 1921 | L | Nevada | 13 | Pacific Fleet (CA) | 14 | Reno, NV | |
| 1921 | W | Nevada | 28 | Utah | 7 | Reno, NV | |
| 1921 | L | Nevada | 6 | California | 51 | Berkeley, CA | |
| 1921 | W | Nevada | 54 | Agnetian AC (CA) | 0 | Reno, NV | |
| 1921 | T | Nevada | 14 | Stanford (CA) | 14 | Stanford, CA | |
| 1921 | L | New Albany HS (IN) | 7 | Elizabethtown HS (KY) | 34 | ? | |
| 1921 | T | New Albany HS (MS) | 0 | Clarksdale HS (MS) | 0 | ? | |
| 1921 | L | New Bedford HS (MA) | 0 | Brockton HS (MA) | 40 | ? | |
| 1921 | W | New Bedford HS (MA) | 19 | Fall River Durfee HS (MA) | 13 | ? | |
| 1921 | L | New Bedford HS (MA) | 0 | Fall River Durfee HS (MA) | 13 | ? | |
| 1921 | L | New Bedford HS (MA) | 0 | Haverhill HS (MA) | 32 | ? | |
| 1921 | L | New Bedford HS (MA) | 0 | Moses Brown School (RI) | 12 | ? | |
| 1921 | W | New Bern HS (NC) | 32 | Rocky Mount HS (NC) | 0 | ? | |
| 1921 | L | New Brighton HS (PA) | 0 | New Castle HS (PA) | 7 | ? | |
| 1921 | L | New Brighton HS (PA) | 0 | Rochester HS (PA) | 6 | ? | |
| 1921 | W | New Britain HS (CT) | 19 | Ansonia HS (CT) | 13 | ? | |
| 1921 | W | New Britain HS (CT) | 46 | Bristol HS (CT) | 0 | ? | |
| 1921 | W | New Britain HS (CT) | 6 | Connecticut JV | 0 | ? | |
| 1921 | W | New Britain HS (CT) | 9 | Hartford HS (CT) | 0 | ? | |
| 1921 | W | New Britain HS (CT) | 6 | Holyoke HS (MA) | 0 | ? | |
| 1921 | W | New Britain HS (CT) | 3 | Meriden HS (CT) | 0 | ? | |
| 1921 | W | New Britain HS (CT) | 10 | New Haven HS (CT) | 6 | ? | |
| 1921 | W | New Britain HS (CT) | 21 | New York Columbia Grammar HS (NY) | 0 | ? | |
| 1921 | W | New Brunswick HS (NJ) | 9 | Battin HS (NJ) | 0 | ? | |
| 1921 | W | New Brunswick HS (NJ) | 19 | Bordentown Military Institute (NJ) | 0 | ? | |
| 1921 | L | New Brunswick HS (NJ) | 0 | Newark Central HS (NJ) | 14 | ? | |
| 1921 | W | New Brunswick HS (NJ) | 1 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | L | New Brunswick HS (NJ) | 13 | Passaic HS (NJ) | 14 | ? | |
| 1921 | W | New Brunswick HS (NJ) | 14 | Plainfield HS (NJ) | 7 | ? | |
| 1921 | W | New Brunswick HS (NJ) | 13 | Princeton HS (NJ) | 7 | ? | |
| 1921 | W | New Brunswick HS (NJ) | 16 | Rutgers Prep School (NJ) | 0 | ? | |
| 1921 | T | New Brunswick HS JV (NJ) | 0 | Plainfield HS JV (NJ) | 0 | ? | |
| 1921 | L | New Castle HS (DE) | 6 | Newark HS (DE) | 20 | ? | |
| 1921 | L | New Castle HS (DE) | 7 | Newark HS (DE) | 26 | ? | |
| 1921 | L | New Castle HS (PA) | 0 | Beaver Falls HS (PA) | 6 | ? | |
| 1921 | W | New Castle HS (PA) | 7 | Butler HS (PA) | 0 | ? | |
| 1921 | T | New Castle HS (PA) | 0 | Ellwood HS (PA) | 0 | ? | |
| 1921 | W | New Castle HS (PA) | 14 | Evans City HS (PA) | 0 | ? | |
| 1921 | W | New Castle HS (PA) | 12 | McKeesport HS (PA) | 0 | ? | |
| 1921 | W | New Castle HS (PA) | 7 | New Brighton HS (PA) | 0 | ? | |
| 1921 | W | New Castle HS (PA) | 21 | New Wilmington HS (PA) | 0 | ? | |
| 1921 | L | New Castle HS (PA) | 0 | Penns Grove HS (NJ) | 44 | ? | |
| 1921 | L | New Castle HS (PA) | 0 | Sharon HS (PA) | 7 | ? | |
| 1921 | W | New Castle HS (PA) | 18 | South Hills HS (PA) | 0 | ? | |
| 1921 | W | New Hampshire | 14 | Bates (ME) | 0 | Lewiston, ME | |
| 1921 | W | New Hampshire | 13 | Holy Cross (MA) | 7 | Manchester, NH | |
| 1921 | W | New Hampshire | 41 | Massachusetts-Lowell | 7 | Dover, NH | |
| 1921 | T | New Hampshire | 0 | Springfield (MA) | 0 | Springfield, MA | |
| 1921 | W | New Hampshire | 55 | USMC Portsmouth (NH) | 0 | Dover, NH | |
| 1921 | W | New Hampshire | 21 | Vermont | 7 | Burlington, VT | |
| 1921 | W | New Hampshire | 10 | Army (NY) | 7 | West Point, NY | |
| 1921 | W | New Hampshire | 24 | Colby (ME) | 7 | Waterville, ME | |
| 1921 | L | New Hampshire | 0 | Dartmouth (NH) | 24 | Hanover, NH | |
| 1921 | W | New Hampshire | 56 | Massachusetts | 7 | Durham, NH | |
| 1921 | T | New Hampshire Freshmen | 0 | Saint John's Prep (MA) | 0 | ? | |
| 1921 | L | New Hampshire Freshmen | 0 | Tilton Seminary (NH) | 6 | ? | |
| 1921 | L | New Hampshire Institute | 0 | Colby Academy (NH) | 21 | ? | |
| 1921 | L | New Hampton HS (IA) | 0 | Osage HS (IA) | 42 | ? | |
| 1921 | L | New Hampton School (NH) | 7 | Tilton Seminary (NH) | 14 | ? | |
| 1921 | W | New Hanover HS (NC) | 7 | Fayetteville HS (NC) | 0 | ? | |
| 1921 | L | New Hanover HS (NC) | 0 | Fayetteville HS (NC) | 21 | ? | |
| 1921 | L | New Hanover HS (NC) | 0 | Fayetteville HS (NC) | 13 | ? | |
| 1921 | W | New Hanover HS (NC) | 13 | Goldsboro HS (NC) | 0 | ? | |
| 1921 | W | New Hanover HS (NC) | 14 | Hamlet HS (NC) | 3 | ? | |
| 1921 | T | New Hanover HS (NC) | 7 | Kinston HS (NC) | 7 | ? | |
| 1921 | W | New Hanover HS (NC) | 34 | Kinston HS (NC) | 7 | ? | |
| 1921 | W | New Jersey (NJ) | 64 | Cathedral HS | 0 | ? | |
| 1921 | W | New Jersey (NJ) | 38 | Lambertville HS (NJ) | 0 | ? | |
| 1921 | W | New Jersey (NJ) | 48 | Peddie Institute (NJ) | 0 | ? | |
| 1921 | W | New Jersey (NJ) | 27 | Pennsylvania Institution for the Deaf | 0 | ? | |
| 1921 | W | New Jersey (NJ) | 27 | Princeton HS (NJ) | 0 | ? | |
| 1921 | W | New Jersey (NJ) | 17 | Rider (NJ) | 0 | Ewing, NJ | |
| 1921 | W | New Jersey School for the Deaf | 31 | Bristol HS (PA) | 0 | ? | |
| 1921 | L | New Jersey School for the Deaf | 0 | Delaware Valley (PA) | 7 | ? | |
| 1921 | L | New London HS (CT) | 0 | Crosby HS (CT) | 35 | ? | |
| 1921 | L | New London HS (CT) | 0 | Stamford HS (CT) | 13 | ? | |
| 1921 | W | New London Submarine Base (CT) | 84 | Crasho AC (CT) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 25 | Harris AC (MA) | 0 | ? | |
| 1921 | L | New London Submarine Base (CT) | 0 | Hartford All-Stars (CT) | 13 | ? | |
| 1921 | W | New London Submarine Base (CT) | 14 | Hartford All-Stars (CT) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 7 | Harvard JV (MA) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 87 | Lenox AC (CT) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 85 | Marine Barracks (NH) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 55 | Newport American Legion (RI) | 0 | ? | |
| 1921 | L | New London Submarine Base (CT) | 7 | Newport News Apprentice School (VA) | 33 | ? | |
| 1921 | W | New London Submarine Base (CT) | 31 | Newport Torpedo Station (RI) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 112 | Receiving Ship (NY) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 13 | Rhode Island | 0 | New London, CT | |
| 1921 | W | New London Submarine Base (CT) | 42 | Steam Rollers (RI) | 0 | ? | |
| 1921 | W | New London Submarine Base (CT) | 68 | Worcester Trade (MA) | 0 | ? | |
| 1921 | L | New London Vocational HS (CT) | 0 | Connecticut JV | 13 | ? | Connecticut JV in question |
| 1921 | L | New London Vocational HS (CT) | 0 | Harford Bulkeley HS (CT) | 19 | ? | |
| 1921 | W | New London Vocational HS (CT) | 3 | Harford Bulkeley HS (CT) | 0 | ? | |
| 1921 | W | New London Vocational HS (CT) | 44 | Killingly HS (CT) | 6 | ? | |
| 1921 | W | New London Vocational HS (CT) | 24 | Norwich Free Academy (CT) | 0 | ? | |
| 1921 | W | New London Vocational HS (CT) | 19 | Norwich Free Academy (CT) | 0 | ? | |
| 1921 | W | New London Vocational HS (CT) | 41 | Stonington HS (CT) | 0 | ? | |
| 1921 | W | New London Vocational HS (CT) | 1 | Stonington HS (CT) | 0 | ? | |
| 1921 | W | New London Vocational HS (CT) | 13 | Westerly HS (RI) | 0 | ? | |
| 1921 | W | New London Vocational HS (CT) | 13 | Westerly HS (RI) | 7 | ? | |
| 1921 | W | New London Vocational HS (CT) | 20 | Windham HS (CT) | 0 | ? | |
| 1921 | W | New Martinsville HS (WV) | 30 | Richland District HS (WV) | 0 | ? | |
| 1921 | L | New Martinsville HS (WV) | 19 | Spencer HS (WV) | 21 | ? | |
| 1921 | T | New Martinsville HS (WV) | 0 | Triadelphia HS (WV) | 0 | ? | |
| 1921 | L | New Martinsville HS (WV) | 0 | Wheeling HS (WV) | 6 | ? | |
| 1921 | L | New Mexico | 0 | Arizona | 24 | Albuquerque, NM | |
| 1921 | L | New Mexico | 0 | Colorado College | 7 | Colorado Springs, CO | |
| 1921 | W | New Mexico | 6 | New Mexico St. | 0 | Albuquerque, NM | |
| 1921 | W | New Mexico | 35 | Fort Bliss (TX) | 0 | Albuquerque, NM | |
| 1921 | L | New Mexico Military Institute | 0 | Arizona | 110 | Tucson, AZ | |
| 1921 | L | New Mexico Military Institute | 0 | Hardin-Simmons (TX) | 35 | Abilene, TX | |
| 1921 | W | New Mexico Military Institute | 27 | Texas-El Paso | 7 | Roswell, NM | |
| 1921 | W | New Mexico Military Institute | 19 | West Texas A&M | 10 | Roswell, NM | |
| 1921 | L | New Mexico Mines | 0 | New Mexico St. | 32 | Las Cruces, NM | |
| 1921 | L | New Mexico St. | 0 | New Mexico | 6 | Albuquerque, NM | |
| 1921 | W | New Mexico St. | 32 | New Mexico Mines | 0 | Las Cruces, NM | |
| 1921 | W | New Mexico St. | 35 | Texas AC | 0 | Las Cruces, NM | Exhibition Game |
| 1921 | L | New Mexico St. | 0 | Arizona | 31 | Las Cruces, NM | |
| 1921 | W | New Mexico St. | 46 | El Paso HS (TX) | 0 | Las Cruces, NM | Exhibition Game |
| 1921 | W | New Mexico St. | 13 | Texas-El Paso | 0 | El Paso, TX | |
| 1921 | L | New Orleans (LA) | 6 | Southern (LA) | 20 | ? | |
| 1921 | L | New Orleans (LA) | 12 | Southern (LA) | 16 | ? | |
| 1921 | W | New Orleans HS (LA) | 21 | Baton Rouge HS (LA) | 6 | ? | |
| 1921 | L | New Philadelphia HS (OH) | 7 | Akron Central HS (OH) | 28 | ? | |
| 1921 | L | New Richmond HS (WI) | 20 | Stillwater HS (MN) | 26 | ? | |
| 1921 | W | New Rochelle HS (NY) | 24 | Fordham Freshmen (NY) | 0 | ? | |
| 1921 | W | New Rochelle HS (NY) | 14 | Mamaroneck HS (NY) | 0 | ? | |
| 1921 | L | New Rochelle HS (NY) | 7 | Mount Vernon HS (NY) | 20 | ? | |
| 1921 | W | New Rochelle HS (NY) | 14 | Port Chester HS (NY) | 0 | ? | |
| 1921 | L | New Rochelle HS (NY) | 7 | Princeton Prep School (NJ) | 12 | ? | |
| 1921 | T | New Rochelle HS (NY) | 14 | White Plains HS (NY) | 14 | ? | |
| 1921 | W | New Rochelle HS (NY) | 13 | Yonkers HS (NY) | 0 | ? | |
| 1921 | L | New Trier HS | 0 | Deerfield Shields HS (IL) | 43 | ? | |
| 1921 | L | New Trier HS | 0 | La Grange HS (IL) | 38 | ? | |
| 1921 | L | New Trier HS | 0 | Proviso Township HS (IL) | 27 | ? | |
| 1921 | L | New Ulm HS (MN) | 0 | Mankato HS (MN) | 65 | ? | |
| 1921 | L | New Ulm HS (MN) | 0 | Saint Peter HS (MN) | 67 | ? | |
| 1921 | L | New Ulm HS (MN) | 6 | Sleepy Eye HS (MN) | 35 | ? | |
| 1921 | T | New Utrecht HS (NY) | 0 | Brooklyn Boys HS (NY) | 0 | ? | |
| 1921 | T | New Utrecht HS (NY) | 0 | Brooklyn Commercial HS (NY) | 0 | ? | |
| 1921 | T | New Utrecht HS (NY) | 7 | Brooklyn Manual Training HS (NY) | 7 | ? | |
| 1921 | L | New Utrecht HS (NY) | 0 | Brooklyn Poly Prep School (NY) | 35 | ? | |
| 1921 | T | New Utrecht HS (NY) | 7 | City College of New York Freshmen | 7 | ? | |
| 1921 | W | New Utrecht HS (NY) | 7 | Evander Childs HS (NY) | 0 | ? | |
| 1921 | W | New Utrecht HS (NY) | 7 | Long Island Lawrence HS (NY) | 0 | ? | |
| 1921 | L | New Wilmington HS (PA) | 0 | New Castle HS (PA) | 21 | ? | |
| 1921 | T | New York (NY) | 7 | Colgate (NY) | 7 | Johnson City, NY | |
| 1921 | L | New York (NY) | 0 | Columbia (NY) | 19 | New York, NY | |
| 1921 | T | New York (NY) | 7 | Duke (NC) | 7 | New York, NY | Ohio Field |
| 1921 | T | New York (NY) | 7 | Wesleyan (CT) | 7 | New York, NY | Ohio Field |
| 1921 | W | New York (NY) | 26 | Hobart (NY) | 0 | New York, NY | Ohio Field |
| 1921 | L | New York (NY) | 0 | Brown (RI) | 13 | Providence, RI | |
| 1921 | W | New York (NY) | 28 | Trinity (CT) | 0 | New York, NY | Ohio Field |
| 1921 | L | New York (NY) | 7 | Rutgers (NJ) | 21 | New York, NY | Ohio Field |
| 1921 | L | New York Columbia Grammar HS (NY) | 0 | Evander Childs HS (NY) | 12 | ? | |
| 1921 | L | New York Columbia Grammar HS (NY) | 0 | New Britain HS (CT) | 21 | ? | |
| 1921 | W | New York Erasmus Hall HS (NY) | 6 | Brooklyn Boys HS (NY) | 0 | ? | |
| 1921 | W | New York Erasmus Hall HS (NY) | 31 | Brooklyn Commercial HS (NY) | 0 | ? | |
| 1921 | L | New York Erasmus Hall HS (NY) | 0 | Brooklyn Manual Training HS (NY) | 7 | ? | |
| 1921 | T | New York Erasmus Hall HS (NY) | 0 | Brooklyn Poly Prep School (NY) | 0 | ? | |
| 1921 | W | New York Erasmus Hall HS (NY) | 13 | Flushing HS (NY) | 0 | ? | |
| 1921 | W | New York Erasmus Hall HS (NY) | 13 | Saint John's HS | 0 | ? | |
| 1921 | T | New York Freshmen (NY) | 0 | City College of New York Freshmen | 0 | ? | |
| 1921 | W | New York Freshmen (NY) | 51 | Saint Francis Prep (NY) | 0 | ? | |
| 1921 | W | New York Freshmen (NY) | 6 | Bridgeport HS (CT) | 0 | New York, NY | Ohio Field |
| 1921 | L | New York HS of Commerce (NY) | 7 | Bridgeport HS (CT) | 13 | ? | |
| 1921 | T | New York HS of Commerce (NY) | 0 | Brooklyn Boys HS (NY) | 0 | ? | |
| 1921 | T | New York HS of Commerce (NY) | 0 | Concordia Prep School (NY) | 0 | ? | |
| 1921 | L | New York HS of Commerce (NY) | 0 | Dewitt Clinton HS (NY) | 7 | ? | |
| 1921 | W | New York HS of Commerce (NY) | 13 | Evander Childs HS (NY) | 0 | ? | |
| 1921 | L | New York HS of Commerce (NY) | 0 | Fordham Prep (NY) | 25 | ? | |
| 1921 | L | New York HS of Commerce (NY) | 0 | Stuyvesant HS (NY) | 13 | ? | |
| 1921 | W | New York HS of Commerce (NY) | 13 | New York Morris HS (NY) | 7 | Bronx, NY | Catholic Protectory Grounds |
| 1921 | L | New York Military Academy | 0 | Columbia Freshmen (NY) | 14 | ? | |
| 1921 | W | New York Military Academy | 15 | Fordham Prep (NY) | 7 | ? | |
| 1921 | W | New York Military Academy | 28 | Hoboken Stevens Prep HS (NJ) | 7 | ? | |
| 1921 | L | New York Military Academy | 7 | Peddie Institute (NJ) | 13 | ? | |
| 1921 | W | New York Military Academy | 6 | Port Jervis HS (NY) | 0 | ? | |
| 1921 | T | New York Military Academy | 13 | Saint Stephen's College (NY) | 13 | ? | |
| 1921 | W | New York Military Academy | 61 | SUNY-Farmingdale (NY) | 0 | ? | |
| 1921 | W | New York Military Academy JV | 15 | Spring Valley HS (NY) | 6 | ? | |
| 1921 | T | New York Morris HS (NY) | 0 | Clason Military Academy (NY) | 0 | ? | |
| 1921 | L | New York Morris HS (NY) | 0 | Concordia Prep School (NY) | 32 | ? | |
| 1921 | L | New York Morris HS (NY) | 6 | Dewitt Clinton HS (NY) | 21 | ? | |
| 1921 | L | New York Morris HS (NY) | 0 | Evander Childs HS (NY) | 20 | ? | |
| 1921 | L | New York Morris HS (NY) | 0 | Flushing HS (NY) | 26 | ? | |
| 1921 | W | New York Morris HS (NY) | 7 | Lawrence HS (NY) | 6 | ? | |
| 1921 | L | New York Morris HS (NY) | 0 | Stuyvesant HS (NY) | 28 | ? | |
| 1921 | L | New York Morris HS (NY) | 7 | New York HS of Commerce (NY) | 13 | Bronx, NY | Catholic Protectory Grounds |
| 1921 | L | Newark Academy (NJ) | 6 | Chatham HS (NJ) | 13 | ? | |
| 1921 | W | Newark Academy (NJ) | 30 | Hoboken Stevens Prep HS (NJ) | 0 | ? | |
| 1921 | W | Newark Academy (NJ) | 33 | Hoboken Stevens Prep HS (NJ) | 0 | ? | |
| 1921 | W | Newark Academy (NJ) | 13 | Jersey City Lincoln HS (NJ) | 0 | ? | |
| 1921 | T | Newark Academy (NJ) | 21 | Morristown School (NJ) | 21 | ? | |
| 1921 | L | Newark Academy (NJ) | 0 | Orange HS (NJ) | 19 | ? | |
| 1921 | L | Newark Academy (NJ) | 0 | Orange HS (NJ) | 18 | ? | |
| 1921 | L | Newark Academy (NJ) | 7 | Stone School (NY) | 14 | ? | |
| 1921 | L | Newark Barringer HS (NJ) | 6 | East Orange HS (NJ) | 14 | ? | |
| 1921 | W | Newark Barringer HS (NJ) | 7 | Jersey City Dickinson HS (NJ) | 6 | ? | |
| 1921 | L | Newark Barringer HS (NJ) | 0 | Lawrenceville School (NJ) | 26 | ? | |
| 1921 | W | Newark Barringer HS (NJ) | 13 | Montclair HS (NJ) | 0 | ? | |
| 1921 | L | Newark Barringer HS (NJ) | 0 | Newark Central HS (NJ) | 14 | ? | |
| 1921 | T | Newark Barringer HS (NJ) | 7 | Newark East Side HS (NJ) | 7 | ? | |
| 1921 | W | Newark Barringer HS (NJ) | 13 | Newark South Side HS (NJ) | 7 | ? | |
| 1921 | T | Newark Barringer HS (NJ) | 0 | Paterson HS (NJ) | 0 | ? | |
| 1921 | W | Newark Barringer HS (NJ) | 6 | Phillipsburg HS (NJ) | 0 | ? | |
| 1921 | W | Newark Central HS (NJ) | 28 | Bloomfield HS (NJ) | 0 | ? | |
| 1921 | W | Newark Central HS (NJ) | 7 | Montclair HS (NJ) | 6 | ? | |
| 1921 | W | Newark Central HS (NJ) | 14 | New Brunswick HS (NJ) | 0 | ? | |
| 1921 | W | Newark Central HS (NJ) | 14 | Newark Barringer HS (NJ) | 0 | ? | |
| 1921 | W | Newark Central HS (NJ) | 23 | Newark East Side HS (NJ) | 0 | ? | |
| 1921 | W | Newark Central HS (NJ) | 21 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | L | Newark Central HS (NJ) | 0 | Rutherford HS (NJ) | 10 | ? | |
| 1921 | L | Newark Central HS (NJ) | 6 | Rutherford HS (NJ) | 10 | ? | |
| 1921 | W | Newark Central HS (NJ) | 21 | Saint Benedict Prep School (NJ) | 7 | ? | |
| 1921 | W | Newark Central HS (NJ) | 24 | South Orange Columbia HS (NJ) | 0 | ? | |
| 1921 | W | Newark Central HS (NJ) | 60 | White Plains HS (NY) | 0 | ? | |
| 1921 | W | Newark HS (DE) | 26 | Bridgeville HS (DE) | 0 | ? | |
| 1921 | W | Newark HS (DE) | 14 | Chestertown HS (MD) | 3 | ? | |
| 1921 | L | Newark HS (DE) | 0 | Elkton HS (MD) | 7 | ? | |
| 1921 | W | Newark HS (DE) | 39 | Elkton HS (MD) | 0 | ? | |
| 1921 | W | Newark HS (DE) | 20 | New Castle HS (DE) | 6 | ? | |
| 1921 | W | Newark HS (DE) | 26 | New Castle HS (DE) | 7 | ? | |
| 1921 | L | Newark HS (DE) | 6 | Salesianum HS (DE) | 20 | ? | |
| 1921 | W | Newark HS (DE) | 67 | Smyrna HS (DE) | 0 | ? | |
| 1921 | L | Newark HS (DE) | 0 | Wilmington HS (OH) | 20 | ? | |
| 1921 | W | Newark HS (OH) | 14 | Columbus South HS (OH) | 0 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 7 | Adelphi Academy (NY) | 20 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | Battin HS (NJ) | 21 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | Bloomfield HS (NJ) | 25 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | Freeport HS (NY) | 7 | ? | |
| 1921 | W | Newark South Side HS (NJ) | 20 | Irvington HS (NJ) | 13 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | Montclair HS (NJ) | 27 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | New Brunswick HS (NJ) | 1 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 7 | Newark Barringer HS (NJ) | 13 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | Newark Central HS (NJ) | 21 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 7 | Nutley HS (NJ) | 27 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | Passaic HS (NJ) | 23 | ? | |
| 1921 | L | Newark South Side HS (NJ) | 0 | Plainfield HS (NJ) | 41 | ? | |
| 1921 | W | Newbern HS | 34 | Durham HS (NC) | 7 | ? | |
| 1921 | W | Newberry (SC) | 41 | College of Charleston (SC) | 0 | Newberry, SC | |
| 1921 | W | Newberry (SC) | 15 | Presbyterian (SC) | 7 | Newberry, SC | |
| 1921 | W | Newberry (SC) | 33 | Wofford (SC) | 21 | Spartanburg, SC | |
| 1921 | L | Newberry (SC) | 0 | Furman (SC) | 63 | Greenville, SC | |
| 1921 | T | Newberry (SC) | 7 | Citadel (SC) | 7 | Newberry, SC | |
| 1921 | L | Newberry (SC) | 0 | South Carolina | 7 | Columbia, SC | |
| 1921 | L | Newberry (SC) | 13 | Erskine (SC) | 18 | Due West, SC | |
| 1921 | L | Newburg HS (NY) | 10 | Poughkeepsie HS (NY) | 48 | ? | |
| 1921 | L | Newburgh Free Academy (NY) | 0 | Binghamton Central HS (NY) | 35 | ? | |
| 1921 | L | Newburgh Free Academy (NY) | 2 | Middletown HS (NY) | 7 | ? | |
| 1921 | L | Newburgh HS (NY) | 7 | Poughkeepsie HS (NY) | 19 | ? | |
| 1921 | W | Newburyport HS (MA) | 7 | Essex County Agriculture School (MA) | 0 | ? | |
| 1921 | W | Newburyport HS (MA) | 7 | Phillips Exeter Academy (NH) | 0 | ? | |
| 1921 | L | Newcastle HS (WY) | 14 | Edgemont HS (SD) | 35 | ? | |
| 1921 | L | Newcastle HS (WY) | 0 | Edgemont HS (SD) | 21 | ? | |
| 1921 | L | Newcastle HS (WY) | 0 | Edgemont HS (SD) | 31 | ? | |
| 1921 | L | Newcastle HS (WY) | 0 | Sheridan HS (WY) | 59 | ? | |
| 1921 | W | Newman School (NJ) | 7 | Park Ridge HS (NJ) | 0 | ? | |
| 1921 | L | Newman School (NJ) | 0 | Pingry School (NJ) | 14 | ? | |
| 1921 | L | Newman School (NJ) | 0 | Princeton Prep School (NJ) | 47 | ? | |
| 1921 | W | Newman School (NJ) | 13 | Red Bank HS (NJ) | 0 | ? | |
| 1921 | W | Newman School (NJ) | 33 | Saint Francis Xavier | 0 | ? | |
| 1921 | W | Newman School (NJ) | 33 | Saint Mary's HS | 0 | ? | |
| 1921 | W | Newman School (NJ) | 27 | Toms River HS (NJ) | 0 | ? | |
| 1921 | L | Newport American Legion (RI) | 0 | New London Submarine Base (CT) | 55 | ? | |
| 1921 | L | Newport HS (KY) | 0 | Louisville HS (KY) | 34 | ? | |
| 1921 | W | Newport News Apprentice School (VA) | 19 | Hampton HS (VA) | 0 | ? | |
| 1921 | W | Newport News Apprentice School (VA) | 33 | New London Submarine Base (CT) | 7 | ? | |
| 1921 | W | Newport News Apprentice School (VA) | 18 | Norfolk Maury HS (VA) | 0 | ? | |
| 1921 | W | Newport News Apprentice School (VA) | 38 | Norfolk Navy Yard (VA) | 0 | ? | |
| 1921 | W | Newport News Apprentice School (VA) | 8 | Virginia Freshmen | 0 | ? | |
| 1921 | L | Newport News Apprentice School (VA) | 6 | Virginia Tech JV | 14 | ? | |
| 1921 | L | Newport News Apprentice School (VA) | 3 | Washington Technical HS (DC) | 12 | ? | |
| 1921 | L | Newport News Apprentice School (VA) | 0 | William & Mary JV (VA) | 23 | ? | |
| 1921 | W | Newport News HS (VA) | 32 | Fort Eustis (VA) | 0 | ? | |
| 1921 | W | Newport News HS (VA) | 64 | Franktown HS (VA) | 0 | ? | |
| 1921 | W | Newport News HS (VA) | 7 | Hampton HS (VA) | 6 | ? | |
| 1921 | L | Newport News HS (VA) | 0 | Norfolk Maury HS (VA) | 7 | ? | |
| 1921 | W | Newport News HS (VA) | 21 | Norfolk South HS (VA) | 7 | ? | |
| 1921 | W | Newport News HS (VA) | 41 | Petersburg HS (VA) | 0 | ? | |
| 1921 | W | Newport News HS (VA) | 7 | Portsmouth HS (VA) | 0 | ? | |
| 1921 | W | Newport News HS (VA) | 20 | Richmond HS (VA) | 6 | ? | |
| 1921 | W | Newport News HS (VA) | 49 | Richmond Oceana HS (VA) | 0 | ? | |
| 1921 | W | Newport News HS (VA) | 41 | Suffolk HS (VA) | 0 | ? | |
| 1921 | L | Newport Torpedo Station (RI) | 0 | New London Submarine Base (CT) | 31 | ? | |
| 1921 | L | Newton HS (NC) | 0 | Lenoir-Rhyne (NC) | 50 | ? | |
| 1921 | L | Newton HS (NJ) | 7 | Blair Hall Academy (NJ) | 26 | ? | |
| 1921 | W | Newton HS (NJ) | 35 | Butler HS (NJ) | 0 | ? | |
| 1921 | L | Newton HS (NJ) | 0 | Dover HS (NJ) | 7 | ? | |
| 1921 | W | Newton HS (NJ) | 46 | Flemington HS (NJ) | 7 | ? | |
| 1921 | W | Newton HS (NJ) | 59 | Hackettstown HS (NJ) | 0 | ? | |
| 1921 | L | Newton HS (NJ) | 0 | Port Jervis HS (NY) | 19 | ? | |
| 1921 | W | Newton HS (NJ) | 19 | Roxbury HS (NJ) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 12 | Brookline HS (MA) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 14 | Cambridge Latin & HS (MA) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 10 | Everett HS (MA) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 13 | Malden HS (MA) | 7 | ? | |
| 1921 | W | Newton North HS (MA) | 7 | Medford HS (MA) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 7 | Quincy HS (MA) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 16 | Rindge Tech (MA) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 41 | Somerville HS (MA) | 0 | ? | |
| 1921 | W | Newton North HS (MA) | 27 | Waltham HS (MA) | 0 | ? | |
| 1921 | L | Newtown HS (PA) | 0 | Bordentown Manual Training (NJ) | 6 | ? | |
| 1921 | L | Newtown HS (PA) | 0 | Bristol HS (PA) | 59 | ? | |
| 1921 | L | Newtown HS (PA) | 0 | Burlington HS (NJ) | 58 | ? | |
| 1921 | T | Niagara (NY) | 0 | Alfred (NY) | 0 | Alfred, NY | |
| 1921 | W | Niagara (NY) | 21 | Canisius (NY) | 0 | Buffalo, NY | |
| 1921 | W | Niagara (NY) | 13 | John Carroll (OH) | 7 | Cleveland, OH | |
| 1921 | T | Niagara (NY) | 0 | Rochester Optometry (NY) | 0 | ? | |
| 1921 | W | Niagara (NY) | 6 | Saint Bonaventure (NY) | 3 | Niagara Falls, NY | |
| 1921 | L | Niagara (NY) | 0 | Springfield (MA) | 40 | Springfield, MA | |
| 1921 | L | Niagara (NY) | 0 | Rochester (NY) | 7 | Rochester, NY | |
| 1921 | L | Niagara (NY) | 7 | Hobart (NY) | 10 | Geneva, NY | |
| 1921 | L | Niagara Falls HS (NY) | 0 | Tonawanda HS (NY) | 28 | ? | |
| 1921 | L | Nichols Prep School (NY) | 14 | Buffalo Technical HS (NY) | 21 | ? | |
| 1921 | L | Nichols School (NY) | 0 | Shady Side Academy (PA) | 27 | ? | |
| 1921 | L | Nickerson HS (KS) | 0 | Kingman HS (KS) | 73 | ? | |
| 1921 | T | Niles HS (OH) | 0 | Warren HS (OH) | 0 | ? | |
| 1921 | L | Niles HS (OH) | 6 | Youngstown South HS (OH) | 21 | ? | |
| 1921 | W | Noble & Greenough (MA) | 13 | Browne & Nichols School (MA) | 0 | ? | |
| 1921 | L | Noble & Greenough (MA) | 0 | Roxbury Latin School (MA) | 14 | ? | |
| 1921 | W | Noble & Greenough (MA) | 7 | Thayer Academy (MA) | 6 | ? | |
| 1921 | T | Nor. & West (Ath.) | 13 | Chatham Training School (VA) | 13 | ? | |
| 1921 | W | Norfolk Agri. | 21 | Essex County Agriculture School (MA) | 6 | ? | |
| 1921 | L | Norfolk Maury HS (VA) | 0 | Newport News Apprentice School (VA) | 18 | ? | |
| 1921 | W | Norfolk Maury HS (VA) | 7 | Newport News HS (VA) | 0 | ? | |
| 1921 | W | Norfolk Maury HS (VA) | 28 | Roanoke HS (VA) | 0 | ? | |
| 1921 | L | Norfolk Navy Yard (VA) | 0 | Newport News Apprentice School (VA) | 38 | ? | |
| 1921 | L | Norfolk Navy Yard (VA) | 0 | Staunton Military Academy (VA) | 14 | ? | |
| 1921 | L | Norfolk South HS (VA) | 7 | Newport News HS (VA) | 21 | ? | |
| 1921 | L | Normal HS (IL) | 0 | Lincoln HS (IL) | 7 | ? | |
| 1921 | L | Norristown HS (PA) | 14 | Allentown HS (PA) | 46 | ? | |
| 1921 | L | Norristown HS (PA) | 0 | Bethlehem HS (PA) | 14 | ? | |
| 1921 | W | Norristown HS (PA) | 24 | Germantown HS (PA) | 7 | ? | |
| 1921 | L | Norristown HS (PA) | 0 | La Salle Prep School (PA) | 14 | ? | |
| 1921 | L | Norristown HS (PA) | 7 | Lebanon HS (PA) | 11 | ? | |
| 1921 | W | Norristown HS (PA) | 66 | Narberth HS (PA) | 0 | ? | |
| 1921 | L | Norristown HS (PA) | 0 | Phoenixville HS (PA) | 6 | ? | |
| 1921 | W | Norristown HS (PA) | 19 | Pottstown HS (PA) | 0 | ? | |
| 1921 | W | Norristown HS (PA) | 25 | Reading HS (PA) | 7 | ? | |
| 1921 | W | North Braddock HS (PA) | 25 | Charleroi HS (PA) | 0 | ? | |
| 1921 | L | North Braddock HS (PA) | 0 | Homestead HS (PA) | 13 | ? | |
| 1921 | L | North Braddock HS (PA) | 0 | McKees Rocks HS (PA) | 6 | ? | |
| 1921 | W | North Braddock HS (PA) | 15 | Munhall HS (PA) | 6 | ? | |
| 1921 | W | North Braddock HS (PA) | 6 | Norwin HS | 0 | ? | |
| 1921 | T | North Braddock HS (PA) | 7 | Swissvale HS (PA) | 7 | ? | |
| 1921 | W | North Braddock HS (PA) | 33 | Verona HS (PA) | 0 | ? | |
| 1921 | W | North Carolina | 16 | Maryland | 7 | Baltimore, MD | |
| 1921 | L | North Carolina | 0 | North Carolina St. | 7 | Raleigh, NC | |
| 1921 | T | North Carolina | 7 | South Carolina | 7 | Columbia, SC | |
| 1921 | W | North Carolina | 7 | Virginia | 3 | Chapel Hill, NC | |
| 1921 | W | North Carolina | 21 | Wake Forest (NC) | 0 | Chapel Hill, NC | |
| 1921 | W | North Carolina | 14 | Florida | 10 | Jacksonville, FL | |
| 1921 | W | North Carolina | 20 | Virginia Military Institute | 7 | Richmond, VA | |
| 1921 | L | North Carolina | 0 | Yale (CT) | 34 | New Haven, CT | |
| 1921 | T | North Carolina | 0 | Davidson (NC) | 0 | Winston-Salem, NC | |
| 1921 | L | North Carolina A&T | 0 | Howard (DC) | 33 | ? | |
| 1921 | T | North Carolina A&T | 0 | Livingstone (NC) | 0 | ? | |
| 1921 | L | North Carolina A&T | 6 | Saint Paul's (VA) | 20 | ? | |
| 1921 | L | North Carolina A&T | 0 | Virginia Union | 14 | ? | |
| 1921 | L | North Carolina Central | 0 | Saint Paul's (VA) | 111 | ? | |
| 1921 | L | North Carolina Freshmen | 6 | Bingham Military School (NC) | 20 | ? | |
| 1921 | W | North Carolina Freshmen | 21 | Woodberry Forest School (VA) | 0 | ? | |
| 1921 | T | North Carolina St. | 6 | Maryland | 6 | Baltimore, MD | |
| 1921 | W | North Carolina St. | 7 | North Carolina | 0 | Raleigh, NC | |
| 1921 | W | North Carolina St. | 21 | Randolph-Macon (VA) | 0 | Raleigh, NC | |
| 1921 | T | North Carolina St. | 7 | Virginia Military Institute | 7 | Raleigh, NC | |
| 1921 | W | North Carolina St. | 14 | Wake Forest (NC) | 0 | Raleigh, NC | |
| 1921 | L | North Carolina St. | 0 | Navy (MD) | 40 | Annapolis, MD | |
| 1921 | T | North Carolina St. | 3 | Davidson (NC) | 3 | Charlotte, NC | |
| 1921 | L | North Carolina St. | 0 | Penn St. | 35 | State College, PA | |
| 1921 | L | North Carolina St. | 3 | Virginia Tech | 7 | Norfolk, VA | |
| 1921 | W | North Carolina St. Freshmen | 12 | Chapel Hill HS (NC) | 0 | ? | |
| 1921 | L | North Central (IL) | 6 | Kalamazoo (MI) | 21 | Kalamazoo, MI | |
| 1921 | W | North Central (IL) | 7 | Lake Forest (IL) | 0 | Naperville, IL | |
| 1921 | W | North Central (IL) | 2 | Monmouth (IL) | 0 | Monmouth, IL | |
| 1921 | L | North Central (IL) | 6 | Saint Viator (IL) | 7 | Naperville, IL | |
| 1921 | W | North Central (IL) | 18 | Crane JC (IL) | 0 | Naperville, IL | |
| 1921 | L | North Central (IL) | 7 | Lombard (IL) | 54 | Naperville, IL | |
| 1921 | L | North Central (IL) | 0 | Chicago YMCA College (IL) | 20 | Naperville, IL | |
| 1921 | W | North Dakota | 40 | Fargo College (ND) | 0 | Fargo, ND | |
| 1921 | L | North Dakota | 0 | Hamline (MN) | 14 | Saint Paul, MN | |
| 1921 | W | North Dakota | 38 | North Dakota St. | 3 | Grand Forks, ND | |
| 1921 | W | North Dakota | 21 | South Dakota | 0 | Grand Forks, ND | |
| 1921 | L | North Dakota | 0 | Wisconsin-Superior | 1 | ? | North Dakota Forfeits |
| 1921 | L | North Dakota | 0 | Minnesota | 19 | Minneapolis, MN | |
| 1921 | L | North Dakota | 14 | South Dakota St. | 27 | Brookings, SD | |
| 1921 | W | North Dakota | 64 | Jamestown (ND) | 0 | Grand Forks, ND | |
| 1921 | L | North Dakota | 3 | Marquette (WI) | 7 | Milwaukee, WI | |
| 1921 | L | North Dakota Science | 7 | Concordia-Moorhead (MN) | 42 | Moorhead, MN | |
| 1921 | L | North Dakota Science | 0 | Moorhead St. (MN) | 7 | ? | |
| 1921 | L | North Dakota St. | 6 | Montana | 7 | Missoula, MT | |
| 1921 | W | North Dakota St. | 35 | Moorhead St. (MN) | 0 | Fargo, ND | |
| 1921 | L | North Dakota St. | 3 | North Dakota | 38 | Grand Forks, ND | |
| 1921 | L | North Dakota St. | 0 | South Dakota St. | 54 | Fargo, ND | |
| 1921 | T | North Dakota St. | 0 | Jamestown (ND) | 0 | Jamestown, ND | |
| 1921 | W | North Dakota St. | 19 | Fargo College (ND) | 7 | Fargo, ND | |
| 1921 | W | North Dakota St. | 7 | Northern St. (SD) | 0 | Fargo, ND | |
| 1921 | L | North Georgia | 0 | Oglethorpe (GA) | 37 | Atlanta, GA | |
| 1921 | L | North Georgia | 0 | Wofford (SC) | 22 | Spartanburg, SC | |
| 1921 | W | North Island NAS (CA) | 12 | San Diego St. (CA) | 7 | San Diego, CA | Navy "Sports" Field |
| 1921 | W | North Lewisburg HS (OH) | 32 | Richmond HS (OH) | 6 | ? | |
| 1921 | W | North Platte HS (NE) | 23 | Ansley HS (NE) | 19 | ? | |
| 1921 | W | North Platte HS (NE) | 16 | Columbus HS (NE) | 13 | ? | |
| 1921 | W | North Platte HS (NE) | 176 | Cozad HS (NE) | 0 | ? | |
| 1921 | W | North Platte HS (NE) | 40 | Creighton HS (NE) | 0 | ? | |
| 1921 | W | North Platte HS (NE) | 21 | Gothenburg HS (NE) | 0 | ? | |
| 1921 | W | North Platte HS (NE) | 42 | Harvard HS (NE) | 0 | ? | |
| 1921 | W | North Platte HS (NE) | 27 | Lincoln HS (NE) | 6 | ? | |
| 1921 | W | North Platte HS (NE) | 28 | McCook HS (NE) | 0 | ? | |
| 1921 | W | North Platte HS (NE) | 14 | Nebraska School of Agriculture | 10 | ? | |
| 1921 | W | North Texas | 61 | Burleson College (TX) | 12 | ? | |
| 1921 | L | North Texas | 0 | John Tarleton College (TX) | 13 | ? | |
| 1921 | L | North Texas | 0 | Texas St. | 14 | ? | |
| 1921 | W | North Texas | 41 | Texas-Arlington | 6 | ? | |
| 1921 | W | North Texas | 33 | Wesley College (TX) | 6 | ? | |
| 1921 | L | North Texas | 0 | Hardin-Simmons (TX) | 6 | Denton, TX | |
| 1921 | W | North Tonawanda HS (NY) | 20 | Buffalo Technical HS (NY) | 6 | ? | |
| 1921 | L | North Tonawanda HS (NY) | 0 | Saint John's Military Academy (NY) | 20 | ? | |
| 1921 | L | North Tonawanda HS (NY) | 10 | Syracuse Central HS (NY) | 22 | ? | |
| 1921 | L | North Tonawanda HS (NY) | 0 | Tonawanda HS (NY) | 22 | ? | |
| 1921 | W | Northeastern Oklahoma A&M | 12 | Northeastern St. (OK) | 6 | ? | |
| 1921 | L | Northeastern St. (OK) | 6 | Northeastern Oklahoma A&M | 12 | ? | |
| 1921 | L | Northeastern St. (OK) | 3 | Oklahoma Baptist University | 30 | Tahlequah, OK | |
| 1921 | L | Northeastern St. (OK) | 7 | Southeastern Oklahoma St. | 28 | ? | |
| 1921 | L | Northern Arizona | 14 | Holbrook HS (AZ) | 18 | Flagstaff, AZ | |
| 1921 | W | Northern Arizona | 6 | Holbrook HS (AZ) | 0 | Holbrook, AZ | |
| 1921 | L | Northern Arizona | 0 | Mesa HS (AZ) | 88 | Mesa, AZ | |
| 1921 | L | Northern Arizona | 0 | Phoenix College (AZ) | 77 | Phoenix, AZ | |
| 1921 | L | Northern Arizona | 6 | Prescott HS (AZ) | 27 | Prescott, AZ | |
| 1921 | L | Northern Arizona | 0 | Winslow HS (AZ) | 18 | Flagstaff, AZ | |
| 1921 | L | Northern Colorado | 0 | Colorado College Freshmen | 14 | Colorado Springs, CO | |
| 1921 | T | Northern Colorado | 7 | Colorado School of Mines Freshmen | 7 | Greeley, CO | |
| 1921 | W | Northern Colorado | 3 | Colorado School of Mines Freshmen | 0 | Greeley, CO | |
| 1921 | L | Northern Colorado | 10 | Colorado St. Freshmen | 21 | Greeley, CO | |
| 1921 | L | Northern Colorado | 10 | Denver Freshmen (CO) | 62 | Greeley, CO | |
| 1921 | L | Northern Illinois | 0 | Bradley (IL) | 41 | Peoria, IL | |
| 1921 | W | Northern Illinois | 21 | Elgin Academy (IL) | 0 | Elgin, IL | |
| 1921 | W | Northern Illinois | 62 | Mount Morris (IL) | 9 | DeKalb, IL | |
| 1921 | L | Northern Illinois | 10 | Saint Viator (IL) | 19 | DeKalb, IL | |
| 1921 | L | Northern Illinois | 7 | Wheaton (IL) | 10 | Wheaton, IL | |
| 1921 | W | Northern Illinois | 91 | Elmhurst (IL) | 10 | DeKalb, IL | |
| 1921 | L | Northern Illinois | 0 | Millikin (IL) | 63 | DeKalb, IL | |
| 1921 | L | Northern Illinois | 0 | Wisconsin-Milwaukee | 26 | DeKalb, IL | |
| 1921 | L | Northern Iowa | 7 | Coe (IA) | 13 | Cedar Rapids, IA | |
| 1921 | W | Northern Iowa | 56 | Ellsworth CC (IA) | 0 | Cedar Falls, IA | |
| 1921 | W | Northern Iowa | 66 | Still College (IA) | 0 | ? | |
| 1921 | T | Northern Iowa | 0 | Upper Iowa | 0 | Cedar Falls, IA | |
| 1921 | W | Northern Iowa | 19 | Parsons (IA) | 7 | Cedar Falls, IA | |
| 1921 | W | Northern Iowa | 18 | Buena Vista (IA) | 0 | Storm Lake, IA | |
| 1921 | W | Northern Iowa | 14 | William Penn (IA) | 6 | Oskaloosa, IA | |
| 1921 | L | Northern Michigan | 7 | Michigan Tech | 12 | Houghton, MI | |
| 1921 | W | Northern Michigan | 7 | Michigan Tech | 6 | Marquette, MI | |
| 1921 | W | Northern Michigan | 29 | Gwinn Legion | 0 | Marquette, MI | |
| 1921 | W | Northern Michigan | 27 | Negaunee Legion (MI) | 15 | Marquette, MI | |
| 1921 | L | Northern St. (SD) | 3 | Columbus (SD) | 21 | Sioux Falls, SD | |
| 1921 | L | Northern St. (SD) | 0 | Dakota Wesleyan (SD) | 14 | Aberdeen, SD | |
| 1921 | L | Northern St. (SD) | 0 | South Dakota St. | 40 | Brookings, SD | |
| 1921 | L | Northern St. (SD) | 0 | North Dakota St. | 7 | Fargo, ND | |
| 1921 | W | Northern St. (SD) | 7 | Yankton (SD) | 0 | Aberdeen, SD | |
| 1921 | L | Northfield HS (MN) | 0 | Faribault HS (MN) | 35 | ? | |
| 1921 | L | Northfield HS (MN) | 0 | Mankato HS (MN) | 53 | ? | |
| 1921 | L | Northfield HS (MN) | 0 | New Prague HS (MN) | 39 | ? | |
| 1921 | T | Northfield HS (MN) | 0 | Owatonna HS (MN) | 0 | ? | |
| 1921 | W | Northumberland HS (PA) | 21 | Bloomsburg (PA) | 0 | Bloomsburg, PA | |
| 1921 | W | Northwest Missouri St. | 7 | Central Wesleyan (MO) | 0 | Warrenton, MO | |
| 1921 | L | Northwest Missouri St. | 14 | Missouri Valley | 55 | ? | |
| 1921 | W | Northwest Missouri St. | 9 | Palmer College of Chiropractic (IA) | 7 | ? | |
| 1921 | L | Northwest Missouri St. | 0 | Still College (IA) | 19 | ? | |
| 1921 | L | Northwest Missouri St. | 0 | Truman St. (MO) | 13 | Maryville, MO | |
| 1921 | L | Northwest Missouri St. | 6 | Tarkio (MO) | 23 | ? | |
| 1921 | L | Northwest Missouri St. | 19 | Graceland (IA) | 23 | Maryville, MO | |
| 1921 | L | Northwest Missouri St. | 7 | Central Missouri St. | 33 | Warrensburg, MO | |
| 1921 | L | Northwest School of Agriculture (MN) | 0 | Crookston HS (MN) | 21 | ? | |
| 1921 | L | Northwestern (IL) | 0 | Beloit (WI) | 7 | Evanston, IL | |
| 1921 | W | Northwestern (IL) | 34 | DePaul (IL) | 0 | Evanston, IL | |
| 1921 | L | Northwestern (IL) | 0 | Iowa | 14 | Evanston, IL | |
| 1921 | L | Northwestern (IL) | 0 | Wisconsin | 27 | Evanston, IL | |
| 1921 | L | Northwestern (IL) | 0 | Chicago (IL) | 41 | Chicago, IL | |
| 1921 | L | Northwestern (IL) | 0 | Purdue (IN) | 3 | West Lafayette, IN | |
| 1921 | L | Northwestern (IL) | 0 | Minnesota | 28 | Minneapolis, MN | |
| 1921 | L | Northwestern (WI) | 0 | Carroll (WI) | 7 | Waukesha, WI | |
| 1921 | L | Northwestern (WI) | 6 | Lawrence (WI) | 26 | Watertown, WI | |
| 1921 | W | Northwestern (WI) | 20 | Milton (WI) | 0 | Milton, WI | |
| 1921 | L | Northwestern (WI) | 0 | Ripon (WI) | 28 | Ripon, WI | |
| 1921 | W | Northwestern (WI) | 26 | Wayland Academy (WI) | 14 | ? | |
| 1921 | L | Northwestern (WI) | 0 | Wisconsin-Milwaukee | 13 | ? | |
| 1921 | T | Northwestern (WI) | 0 | Beloit (WI) | 0 | Watertown, WI | |
| 1921 | L | Northwestern Academy (IL) | 0 | Benedictine (IL) | 22 | ? | |
| 1921 | L | Northwestern Academy (IL) | 7 | Benedictine (IL) | 54 | ? | |
| 1921 | L | Northwestern Oklahoma St. | 0 | Central Oklahoma | 42 | ? | |
| 1921 | W | Northwestern Oklahoma St. | 14 | Oklahoma Baptist University | 7 | Alva, OK | |
| 1921 | L | Northwestern Oklahoma St. | 7 | Southeastern Oklahoma St. | 34 | ? | |
| 1921 | T | Northwestern Oklahoma St. | 14 | Southwestern Oklahoma St. | 14 | ? | |
| 1921 | L | Northwestern Oklahoma St. | 7 | Tulsa (OK) | 17 | Tulsa, OK | |
| 1921 | W | Northwestern Oklahoma St. | 23 | University Prep School (OK) | 0 | ? | |
| 1921 | W | Northwestern Oklahoma St. | 14 | West Texas A&M | 7 | Canyon, TX | |
| 1921 | W | Northwestern Oklahoma St. | 69 | Oklahoma City (OK) | 0 | Alva, OK | |
| 1921 | W | Northwestern St. (LA) | 7 | Centenary (LA) | 0 | Shreveport, LA | |
| 1921 | W | Northwestern St. (LA) | 14 | Louisiana College | 6 | Pineville, LA | |
| 1921 | L | Northwestern St. (LA) | 0 | Louisiana Tech | 17 | Ruston, LA | |
| 1921 | L | Northwestern St. (LA) | 2 | Louisiana-Lafayette | 33 | Lafayette, LA | |
| 1921 | W | Northwestern St. (LA) | 14 | Natchitoches HS (LA) | 0 | Natchitoches, LA | |
| 1921 | T | Northwestern St. (LA) | 0 | Saint Charles (LA) | 0 | Grand Coteau, LA | |
| 1921 | L | Northwestern St. (LA) | 0 | Louisiana St. | 78 | Baton Rouge, LA | |
| 1921 | L | Norwalk HS (CT) | 0 | Ansonia HS (CT) | 28 | ? | |
| 1921 | L | Norwalk HS (CT) | 0 | Port Chester HS (NY) | 41 | ? | |
| 1921 | L | Norwalk HS (CT) | 0 | Stamford HS (CT) | 69 | ? | |
| 1921 | L | Norwalk HS (OH) | 7 | Fostoria HS (OH) | 41 | ? | |
| 1921 | L | Norwalk HS (OH) | 0 | Sandusky HS (OH) | 7 | ? | |
| 1921 | W | Norwich (VT) | 39 | Clarkson (NY) | 0 | Northfield, VT | |
| 1921 | L | Norwich (VT) | 3 | Dartmouth (NH) | 34 | Hanover, NH | |
| 1921 | L | Norwich (VT) | 0 | Middlebury (VT) | 3 | Middlebury, VT | |
| 1921 | L | Norwich (VT) | 0 | Tufts (MA) | 6 | Medford, MA | |
| 1921 | W | Norwich (VT) | 14 | Maine | 0 | Orono, ME | |
| 1921 | L | Norwich (VT) | 2 | Vermont | 14 | Northfield, VT | |
| 1921 | T | Norwich (VT) | 0 | Rensselaer Tech (NY) | 0 | Northfield, VT | |
| 1921 | L | Norwich (VT) | 14 | Boston (MA) | 20 | Boston, MA | |
| 1921 | L | Norwich Academy (CT) | 0 | Westerly HS (RI) | 12 | ? | |
| 1921 | W | Norwich Academy (CT) | 7 | Westerly HS (RI) | 6 | ? | |
| 1921 | L | Norwich Free Academy (CT) | 0 | New London Vocational HS (CT) | 24 | ? | |
| 1921 | L | Norwich Free Academy (CT) | 0 | New London Vocational HS (CT) | 19 | ? | |
| 1921 | L | Norwich HS (NY) | 6 | Endicott Union HS (NY) | 19 | ? | |
| 1921 | L | Norwich HS (NY) | 6 | Syracuse North HS (NY) | 7 | ? | |
| 1921 | L | Norwin HS | 0 | Johnstown HS (PA) | 41 | ? | |
| 1921 | L | Norwin HS | 0 | North Braddock HS (PA) | 6 | ? | |
| 1921 | L | Norwin HS | 0 | Wilkinsburg HS (PA) | 14 | ? | |
| 1921 | W | Norwood HS (MA) | 7 | Boston College HS (MA) | 0 | ? | |
| 1921 | W | Norwood HS (MA) | 14 | Boston Commerce HS (MA) | 0 | ? | |
| 1921 | W | Norwood HS (MA) | 48 | Bridgewater HS (MA) | 7 | ? | |
| 1921 | W | Norwood HS (MA) | 21 | Dedham HS (MA) | 6 | ? | |
| 1921 | W | Norwood HS (MA) | 7 | Fairhaven HS (MA) | 6 | ? | |
| 1921 | W | Norwood HS (MA) | 28 | Mansfield HS (MA) | 7 | ? | |
| 1921 | W | Norwood HS (MA) | 13 | Massachusetts-Dartmouth | 0 | ? | |
| 1921 | W | Norwood HS (MA) | 13 | Milton HS (MA) | 0 | ? | |
| 1921 | W | Norwood HS (MA) | 34 | Needham HS (MA) | 7 | ? | |
| 1921 | W | Norwood HS (MA) | 7 | Norwood HS Alumni (MA) | 6 | ? | |
| 1921 | L | Norwood HS Alumni (MA) | 6 | Norwood HS (MA) | 7 | ? | |
| 1921 | W | Notre Dame (IN) | 28 | Indiana | 7 | Indianapolis, IN | |
| 1921 | W | Notre Dame (IN) | 56 | Kalamazoo (MI) | 0 | South Bend, IN | |
| 1921 | W | Notre Dame (IN) | 21 | Marquette (WI) | 7 | Milwaukee, WI | |
| 1921 | W | Notre Dame (IN) | 48 | Michigan St. | 0 | South Bend, IN | |
| 1921 | W | Notre Dame (IN) | 7 | Nebraska | 0 | South Bend, IN | |
| 1921 | W | Notre Dame (IN) | 33 | Purdue (IN) | 0 | West Lafayette, IN | |
| 1921 | W | Notre Dame (IN) | 57 | DePauw (IN) | 10 | South Bend, IN | |
| 1921 | W | Notre Dame (IN) | 28 | Army (NY) | 0 | West Point, NY | |
| 1921 | L | Notre Dame (IN) | 7 | Iowa | 10 | Iowa City, IA | |
| 1921 | W | Notre Dame (IN) | 48 | Rutgers (NJ) | 0 | New York, NY | |
| 1921 | W | Notre Dame (IN) | 42 | Haskell Indian Nations (KS) | 7 | Notre Dame, IN | |
| 1921 | L | Notre Dame Freshmen (IN) | 7 | Albion (MI) | 14 | ? | |
| 1921 | W | Notre Dame Freshmen (IN) | 48 | Culver Military Academy (IN) | 3 | Culver, IN | |
| 1921 | L | Notre Dame Freshmen (IN) | 0 | Western Michigan | 7 | Kalamazoo, MI | |
| 1921 | T | Notre Dame Seniors | 0 | Loyola Academy (IL) | 0 | ? | |
| 1921 | L | Notre Dame Walsh Hall (IN) | 0 | Culver Military Academy (IN) | 50 | ? | |
| 1921 | W | Noxapater HS (MS) | 13 | Ackerman HS (MS) | 0 | ? | |
| 1921 | L | Noxapater HS (MS) | 12 | Ackerman HS (MS) | 21 | ? | |
| 1921 | W | Nutley HS (NJ) | 25 | Asbury Park HS (NJ) | 0 | ? | |
| 1921 | T | Nutley HS (NJ) | 0 | Dover HS (NJ) | 0 | ? | |
| 1921 | W | Nutley HS (NJ) | 17 | Irvington HS (NJ) | 0 | ? | |
| 1921 | W | Nutley HS (NJ) | 48 | Jersey City Lincoln HS (NJ) | 0 | ? | |
| 1921 | W | Nutley HS (NJ) | 27 | Newark South Side HS (NJ) | 7 | ? | |
| 1921 | L | Nutley HS (NJ) | 6 | Passaic HS (NJ) | 14 | ? | |
| 1921 | L | Nutley HS (NJ) | 0 | Phillipsburg HS (NJ) | 13 | ? | |
| 1921 | W | Nutley HS (NJ) | 31 | Rahway HS (NJ) | 0 | ? | |
| 1921 | W | Nutley HS (NJ) | 45 | Summit HS (NJ) | 0 | ? | |
| 1921 | W | Nutley HS (NJ) | 67 | Union Hill HS (NJ) | 0 | ? | |
| 1921 | L | Nutley HS JV (NJ) | 0 | Plainfield HS JV (NJ) | 6 | ? | |
| 1921 | L | Nyack HS (NY) | 0 | Brooklyn Evening HS (NY) | 19 | ? | |
| 1921 | L | Nyack HS (NY) | 0 | Drake AC | 6 | ? | |
| 1921 | L | Nyack HS (NY) | 0 | Drum Hill HS (NY) | 10 | ? | |
| 1921 | L | Nyack HS (NY) | 6 | Englewood HS (NJ) | 27 | ? | |
| 1921 | W | Nyack HS (NY) | 46 | Highland Falls HS (NY) | 0 | ? | |
| 1921 | W | Nyack HS (NY) | 7 | Nyack HS Alumni (NY) | 0 | ? | |
| 1921 | W | Nyack HS (NY) | 20 | Oakside HS | 0 | ? | |
| 1921 | W | Nyack HS (NY) | 19 | Park Ridge HS (NJ) | 7 | ? | |
| 1921 | W | Nyack HS (NY) | 12 | Park Ridge HS (NJ) | 0 | ? | |
| 1921 | W | Nyack HS (NY) | 7 | Spring Valley HS (NY) | 0 | ? | |
| 1921 | L | Nyack HS (NY) | 7 | Spring Valley HS (NY) | 19 | ? | |
| 1921 | T | Nyack HS (NY) | 0 | Yonkers HS (NY) | 0 | ? | |
| 1921 | L | Nyack HS Alumni (NY) | 0 | Nyack HS (NY) | 7 | ? | |
| 1921 | L | Oak Hill HS (WV) | 0 | Alderson (WV) | 6 | ? | Alderson won - score unknown |
| 1921 | L | Oak Hill HS (WV) | 0 | Hinton HS (WV) | 81 | ? | |
| 1921 | L | Oak Park HS (IL) | 0 | Deerfield Shields HS (IL) | 14 | ? | |
| 1921 | L | Oak Park HS (IL) | 7 | La Grange HS (IL) | 10 | ? | |
| 1921 | T | Oak Park HS (IL) | 7 | Proviso Township HS (IL) | 7 | ? | |
| 1921 | L | Oak Ridge Military Academy (TN) | 0 | Chatham Training School (VA) | 14 | ? | |
| 1921 | L | Oakland Tech (CA) | 0 | Berkeley HS (CA) | 55 | ? | |
| 1921 | L | Oakland Tech (CA) | 0 | Glenn County HS (CA) | 13 | ? | |
| 1921 | L | Oakside HS | 0 | Drum Hill HS (NY) | 21 | ? | |
| 1921 | L | Oakside HS | 0 | Nyack HS (NY) | 20 | ? | |
| 1921 | L | Oakside HS | 0 | Peekskill Military Academy (NY) | 20 | ? | |
| 1921 | W | Oberlin (OH) | 38 | Hiram (OH) | 6 | Hiram, OH | |
| 1921 | W | Oberlin (OH) | 13 | Mount Union (OH) | 0 | Alliance, OH | |
| 1921 | W | Oberlin (OH) | 21 | Ohio Wesleyan | 0 | Delaware, OH | |
| 1921 | W | Oberlin (OH) | 7 | Western Reserve (OH) | 0 | Oberlin, OH | |
| 1921 | W | Oberlin (OH) | 16 | Wittenberg (OH) | 0 | Oberlin, OH | |
| 1921 | W | Oberlin (OH) | 14 | Wooster (OH) | 6 | Oberlin, OH | |
| 1921 | W | Oberlin (OH) | 7 | Ohio St. | 6 | Columbus, OH | |
| 1921 | T | Oberlin (OH) | 7 | Case Institute of Technology (OH) | 7 | Cleveland, OH | |
| 1921 | T | Oberlin HS (KS) | 7 | Cambridge HS (NE) | 7 | ? | |
| 1921 | L | Oberlin HS (OH) | 7 | Lakewood HS (OH) | 13 | ? | |
| 1921 | W | Oberlin HS (OH) | 7 | Sandusky HS (OH) | 0 | ? | |
| 1921 | T | Occidental (CA) | 7 | Pomona-Pitzer (CA) | 7 | Pomona, CA | |
| 1921 | L | Occidental (CA) | 7 | Redlands (CA) | 24 | Los Angeles, CA | |
| 1921 | L | Occidental (CA) | 7 | San Pedro Submarine Base (CA) | 14 | ? | |
| 1921 | L | Occidental (CA) | 0 | Southern California | 42 | Los Angeles, CA | |
| 1921 | W | Occidental (CA) | 35 | UCLA | 0 | Los Angeles, CA | |
| 1921 | W | Occidental (CA) | 14 | California Tech | 3 | Los Angeles, CA | |
| 1921 | L | Occidental (CA) | 6 | Whittier (CA) | 10 | Whittier, CA | |
| 1921 | L | Occidental Freshmen (CA) | 0 | Kern County HS (CA) | 42 | ? | |
| 1921 | T | Ocean City HS (NJ) | 7 | Pleasantville HS (NJ) | 7 | ? | |
| 1921 | L | Ocean City HS (NJ) | 0 | Pleasantville HS (NJ) | 7 | ? | |
| 1921 | W | Ocean City HS (NJ) | 13 | Wildwood HS (NJ) | 0 | ? | |
| 1921 | W | Ocean City HS (NJ) | 6 | Wildwood HS (NJ) | 0 | ? | |
| 1921 | L | Oconomowoc HS (WI) | 6 | Watertown HS (WI) | 19 | ? | |
| 1921 | L | Odd Fellows Orphanage | 0 | Smithfield HS (NC) | 12 | ? | |
| 1921 | W | Odd Fellows Orphanage | 14 | Smithfield HS (NC) | 7 | ? | |
| 1921 | L | Oelwein HS (IA) | 0 | Waterloo East HS (IA) | 13 | ? | |
| 1921 | L | Ogden AC (UT) | 7 | Brigham Young (UT) | 48 | Provo, UT | |
| 1921 | W | Ogden AC (UT) | 17 | Brigham Young (UT) | 12 | Ogden, UT | |
| 1921 | L | Ogden AC (UT) | 21 | Utah St. | 47 | Logan, UT | |
| 1921 | L | Ogden College (KY) | 0 | Rhodes (TN) | 30 | ? | |
| 1921 | L | Ogden College (KY) | 14 | Rhodes (TN) | 21 | ? | |
| 1921 | L | Ogden HS (UT) | 13 | Box Elder HS (MT) | 14 | ? | |
| 1921 | W | Ogden HS (UT) | 20 | Davis County HS (UT) | 0 | ? | |
| 1921 | L | Ogden HS (UT) | 0 | Granite HS (UT) | 15 | ? | |
| 1921 | L | Ogden HS (UT) | 6 | Latter Day Saints HS (UT) | 19 | ? | |
| 1921 | W | Ogden HS (UT) | 35 | Park City HS (UT) | 0 | ? | |
| 1921 | W | Ogden HS (UT) | 20 | Tooele HS (UT) | 7 | ? | |
| 1921 | W | Ogden HS (UT) | 22 | Weber JC (UT) | 7 | ? | |
| 1921 | T | Ogdensburg HS (NY) | 13 | Massena HS (NY) | 13 | ? | |
| 1921 | L | Oglethorpe (GA) | 3 | Florida | 21 | Gainesville, FL | |
| 1921 | L | Oglethorpe (GA) | 0 | Georgia | 14 | Athens, GA | |
| 1921 | W | Oglethorpe (GA) | 37 | North Georgia | 0 | Atlanta, GA | |
| 1921 | L | Oglethorpe (GA) | 0 | Sewanee (TN) | 21 | Sewanee, TN | |
| 1921 | W | Oglethorpe (GA) | 7 | Tennessee-Chattanooga | 0 | Atlanta, GA | |
| 1921 | L | Oglethorpe (GA) | 0 | Georgia Tech | 41 | Atlanta, GA | |
| 1921 | W | Oglethorpe (GA) | 41 | Stetson (FL) | 0 | Deland, FL | |
| 1921 | W | Oglethorpe (GA) | 20 | Fort Benning (GA) | 12 | Atlanta, GA | |
| 1921 | W | Oglethorpe (GA) | 7 | Mercer (GA) | 6 | Atlanta, GA | |
| 1921 | L | Oglethorpe JV (GA) | 0 | Piedmont (GA) | 6 | ? | |
| 1921 | W | Ohio | 35 | Baldwin-Wallace (OH) | 0 | Athens, OH | |
| 1921 | W | Ohio | 40 | Charleston (WV) | 0 | Athens, OH | |
| 1921 | L | Ohio | 7 | Denison (OH) | 14 | Granville, OH | |
| 1921 | T | Ohio | 0 | Marietta (OH) | 0 | Athens, OH | |
| 1921 | L | Ohio | 0 | West Virginia | 7 | Morgantown, WV | |
| 1921 | L | Ohio | 0 | Syracuse (NY) | 38 | Syracuse, NY | |
| 1921 | W | Ohio | 7 | Cincinnati (OH) | 6 | Athens, OH | |
| 1921 | L | Ohio | 0 | Bethany (WV) | 13 | Bethany, WV | High School field |
| 1921 | W | Ohio | 23 | Columbia (NY) | 21 | New York, NY | |
| 1921 | L | Ohio Military Institute | 0 | Cincinnati East HS (OH) | 35 | ? | |
| 1921 | L | Ohio Northern | 7 | Akron (OH) | 26 | Akron, OH | |
| 1921 | W | Ohio Northern | 47 | Bluffton (OH) | 0 | Bluffton, OH | Practice Game |
| 1921 | W | Ohio Northern | 35 | Hiram (OH) | 0 | Hiram, OH | |
| 1921 | L | Ohio Northern | 0 | Miami (OH) | 27 | Ada, OH | |
| 1921 | W | Ohio Northern | 7 | Wittenberg (OH) | 0 | Ada, OH | |
| 1921 | L | Ohio Northern | 0 | Xavier (OH) | 13 | Cincinnati, OH | |
| 1921 | W | Ohio Northern | 6 | Western Reserve (OH) | 0 | Ada, OH | |
| 1921 | L | Ohio Northern | 0 | Detroit (MI) | 35 | Detroit, MI | |
| 1921 | W | Ohio Northern | 13 | Heidelberg (OH) | 0 | Ada, OH | |
| 1921 | L | Ohio St. | 0 | Illinois | 7 | Columbus, OH | |
| 1921 | W | Ohio St. | 14 | Michigan | 0 | Ann Arbor, MI | |
| 1921 | W | Ohio St. | 27 | Minnesota | 0 | Columbus, OH | |
| 1921 | L | Ohio St. | 0 | California | 28 | Pasadena, CA | Tournament of Roses Game |
| 1921 | W | Ohio St. | 28 | Ohio Wesleyan | 0 | Columbus, OH | |
| 1921 | W | Ohio St. | 7 | Chicago (IL) | 0 | Chicago, IL | |
| 1921 | L | Ohio St. | 6 | Oberlin (OH) | 7 | Columbus, OH | |
| 1921 | W | Ohio St. | 28 | Purdue (IN) | 0 | Columbus, OH | |
| 1921 | L | Ohio Wesleyan | 14 | Case Institute of Technology (OH) | 19 | Cleveland, OH | |
| 1921 | L | Ohio Wesleyan | 0 | Miami (OH) | 56 | Oxford, OH | |
| 1921 | L | Ohio Wesleyan | 0 | Oberlin (OH) | 21 | Delaware, OH | |
| 1921 | T | Ohio Wesleyan | 0 | Wittenberg (OH) | 0 | Springfield, OH | |
| 1921 | L | Ohio Wesleyan | 0 | Ohio St. | 28 | Columbus, OH | |
| 1921 | L | Ohio Wesleyan | 0 | Denison (OH) | 7 | Delaware, OH | |
| 1921 | W | Ohio Wesleyan | 26 | Heidelberg (OH) | 7 | Delaware, OH | |
| 1921 | L | Ohio Wesleyan | 0 | Western Reserve (OH) | 7 | Delaware, OH | |
| 1921 | W | Oil City HS (PA) | 7 | Clarion (PA) | 0 | Oil City, PA | West End Park |
| 1921 | L | Oklahoma | 7 | Kansas St. | 14 | Manhattan, KS | |
| 1921 | L | Oklahoma | 0 | Nebraska | 44 | Lincoln, NE | |
| 1921 | W | Oklahoma | 6 | Oklahoma St. | 0 | Norman, OK | |
| 1921 | W | Oklahoma | 27 | Rice (TX) | 0 | Houston, TX | |
| 1921 | W | Oklahoma | 28 | Washington (MO) | 13 | Norman, OK | |
| 1921 | W | Oklahoma | 24 | Kansas | 7 | Norman, OK | |
| 1921 | W | Oklahoma | 21 | Central Oklahoma | 0 | Norman, OK | |
| 1921 | L | Oklahoma | 14 | Missouri | 24 | Columbia, MO | |
| 1921 | L | Oklahoma Baptist University | 0 | Central Oklahoma | 7 | Edmond, OK | |
| 1921 | T | Oklahoma Baptist University | 0 | Chilocco Indian School (OK) | 0 | Chilocco, OK | |
| 1921 | W | Oklahoma Baptist University | 6 | Kingfisher (OK) | 0 | Shawnee, OK | |
| 1921 | W | Oklahoma Baptist University | 30 | Northeastern St. (OK) | 3 | Tahlequah, OK | |
| 1921 | L | Oklahoma Baptist University | 7 | Northwestern Oklahoma St. | 14 | Alva, OK | |
| 1921 | W | Oklahoma Baptist University | 12 | Oklahoma City (OK) | 0 | Shawnee, OK | |
| 1921 | L | Oklahoma Baptist University | 0 | Southwestern Oklahoma St. | 13 | Shawnee, OK | |
| 1921 | L | Oklahoma Baptist University | 0 | Tulsa (OK) | 28 | Shawnee, OK | |
| 1921 | L | Oklahoma Baptist University | 3 | Wichita St. (KS) | 28 | Wichita, KS | |
| 1921 | L | Oklahoma City (OK) | 14 | Chilocco Indian School (OK) | 20 | Oklahoma City, OK | |
| 1921 | W | Oklahoma City (OK) | 59 | East Central (OK) | 14 | Oklahoma City, OK | |
| 1921 | L | Oklahoma City (OK) | 0 | Oklahoma Baptist University | 12 | Shawnee, OK | |
| 1921 | W | Oklahoma City (OK) | 20 | University Prep School (OK) | 0 | ? | |
| 1921 | T | Oklahoma City (OK) | 7 | Southwestern Oklahoma St. | 7 | Weatherford, OK | |
| 1921 | L | Oklahoma City (OK) | 9 | Kingfisher (OK) | 20 | Kingfisher, OK | |
| 1921 | L | Oklahoma City (OK) | 0 | Northwestern Oklahoma St. | 69 | Alva, OK | |
| 1921 | T | Oklahoma City HS (OK) | 7 | Altus HS (OK) | 7 | ? | |
| 1921 | W | Oklahoma City HS (OK) | 21 | El Reno HS (OK) | 7 | ? | |
| 1921 | L | Oklahoma City HS (OK) | 0 | Enid HS (OK) | 7 | ? | |
| 1921 | W | Oklahoma City HS (OK) | 30 | Guthrie HS (OK) | 0 | ? | |
| 1921 | W | Oklahoma City HS (OK) | 21 | Lawton HS (OK) | 7 | ? | |
| 1921 | W | Oklahoma City HS (OK) | 21 | McAlester HS (OK) | 0 | ? | |
| 1921 | W | Oklahoma City HS (OK) | 21 | Okmulgee HS (OK) | 7 | ? | |
| 1921 | L | Oklahoma City HS (OK) | 10 | Sapulpa HS (OK) | 37 | ? | |
| 1921 | W | Oklahoma City HS (OK) | 17 | Shawnee HS (OK) | 0 | ? | |
| 1921 | L | Oklahoma City HS (OK) | 7 | Tulsa Central HS (OK) | 14 | ? | |
| 1921 | L | Oklahoma Panhandle St. | 0 | Elkhart HS (KS) | 6 | ? | Elkhart HS won - score unknown |
| 1921 | W | Oklahoma Panhandle St. | 6 | Elkhart HS (KS) | 0 | ? | Oklahoma Panhandle St. won - score unknown |
| 1921 | L | Oklahoma Panhandle St. | 0 | Guymon HS (OK) | 6 | ? | Guymon HS won - score unknown |
| 1921 | W | Oklahoma Panhandle St. | 6 | Hooker HS (OK) | 0 | Goodwell, OK | Oklahoma Panhandle St. won - score unknown |
| 1921 | L | Oklahoma Panhandle St. | 0 | Hugoton HS (KS) | 6 | ? | Hugoton HS won - score unknown |
| 1921 | W | Oklahoma Panhandle St. | 9 | Liberal HS (KS) | 6 | Liberal, KS | |
| 1921 | W | Oklahoma St. | 7 | Arkansas | 0 | Stillwater, OK | |
| 1921 | L | Oklahoma St. | 0 | Oklahoma | 6 | Norman, OK | |
| 1921 | W | Oklahoma St. | 7 | Phillips (OK) | 6 | Enid, OK | |
| 1921 | W | Oklahoma St. | 53 | Southwestern Oklahoma St. | 0 | Stillwater, OK | |
| 1921 | L | Oklahoma St. | 7 | Texas A&M | 23 | College Station, TX | |
| 1921 | W | Oklahoma St. | 13 | Washburn (KS) | 0 | Stillwater, OK | |
| 1921 | L | Oklahoma St. | 0 | Missouri | 36 | Columbia, MO | |
| 1921 | T | Oklahoma St. | 7 | College of Emporia (KS) | 7 | Stillwater, OK | |
| 1921 | W | Oklahoma St. | 28 | Texas Christian | 21 | Stillwater, OK | |
| 1921 | L | Oklahoma St. | 13 | Creighton (NE) | 26 | Omaha, NE | |
| 1921 | L | Okmulgee HS (OK) | 7 | Oklahoma City HS (OK) | 21 | ? | |
| 1921 | L | Okmulgee HS (OK) | 6 | Sapulpa HS (OK) | 40 | ? | |
| 1921 | L | Okmulgee HS (OK) | 0 | Tulsa Central HS (OK) | 27 | ? | |
| 1921 | W | Olathe HS (CO) | 53 | Cedaredge HS (CO) | 0 | ? | |
| 1921 | W | Olathe HS (CO) | 33 | Delta HS (CO) | 3 | ? | |
| 1921 | L | Olathe HS (CO) | 0 | Grand Junction HS (CO) | 14 | ? | |
| 1921 | L | Olathe HS (CO) | 0 | Gunnison HS (CO) | 27 | ? | |
| 1921 | W | Olathe HS (CO) | 37 | Montrose HS (CO) | 0 | ? | |
| 1921 | W | Olathe HS (CO) | 27 | Paonia HS (CO) | 7 | ? | |
| 1921 | L | Olean HS (NY) | 0 | Kane HS (PA) | 6 | ? | |
| 1921 | W | Olivet (MI) | 7 | Adrian (MI) | 0 | ? | |
| 1921 | L | Olivet (MI) | 7 | Albion (MI) | 34 | Olivet, MI | |
| 1921 | W | Olivet (MI) | 21 | Alma (MI) | 0 | ? | |
| 1921 | L | Olivet (MI) | 13 | Hillsdale (MI) | 21 | ? | |
| 1921 | L | Olivet (MI) | 0 | Kalamazoo (MI) | 34 | Olivet, MI | |
| 1921 | L | Olivet (MI) | 0 | Wayne St. (MI) | 26 | Detroit, MI | |
| 1921 | L | Olivet (MI) | 0 | Central Michigan | 25 | Mount Pleasant, MI | |
| 1921 | W | Olivet (MI) | 6 | Grand Rapids JC (MI) | 0 | ? | |
| 1921 | T | Olivet (MI) | 14 | Assumption College (ON) | 14 | ? | |
| 1921 | L | Oltamont HS | 0 | Independence HS (KS) | 48 | ? | |
| 1921 | L | Olympia HS (WA) | 0 | Chehalis HS (WA) | 27 | ? | |
| 1921 | L | Olympia HS (WA) | 0 | Saint Martin's (WA) | 26 | ? | |
| 1921 | W | Oneida HS (NY) | 42 | Cazenovia Seminary (NY) | 0 | ? | |
| 1921 | W | Oneida HS (NY) | 19 | Herkimer HS (NY) | 0 | ? | |
| 1921 | W | Oneida HS (NY) | 7 | Saint John's Military Academy (NY) | 0 | ? | |
| 1921 | W | Oneida HS (NY) | 28 | Sherrill HS (NY) | 7 | ? | |
| 1921 | W | Oneida HS (NY) | 62 | Solvay HS (NY) | 0 | ? | |
| 1921 | W | Oneida HS (NY) | 7 | Syracuse Central HS (NY) | 0 | ? | |
| 1921 | W | Oneida HS (NY) | 48 | Syracuse Vocational School (NY) | 0 | ? | |
| 1921 | L | Oneonta HS (AL) | 0 | Jacksonville St. (AL) | 55 | ? | |
| 1921 | L | Oneonta HS (AL) | 0 | Jacksonville St. (AL) | 42 | ? | |
| 1921 | L | Orange HS (CA) | 0 | San Diego HS (CA) | 48 | ? | |
| 1921 | L | Orange HS (CA) | 0 | Santa Ana HS (CA) | 91 | ? | |
| 1921 | L | Orange HS (CA) | 0 | Sherman Indian School (CA) | 40 | ? | |
| 1921 | W | Orange HS (NJ) | 28 | Bayonne HS (NJ) | 0 | ? | |
| 1921 | L | Orange HS (NJ) | 6 | Bloomfield HS (NJ) | 20 | ? | |
| 1921 | W | Orange HS (NJ) | 28 | Irvington HS (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 14 | Jersey City Lincoln HS (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 18 | Newark Academy (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 19 | Newark Academy (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 18 | Orange HS Alumni (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 34 | Seton Hall Prep School (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 17 | South Orange Columbia HS (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 18 | Summit HS (NJ) | 0 | ? | |
| 1921 | W | Orange HS (NJ) | 41 | West Orange HS (NJ) | 0 | ? | |
| 1921 | W | Orange HS (TX) | 9 | Beaumont HS (TX) | 0 | ? | |
| 1921 | W | Orange HS (TX) | 15 | Galveston Ball HS (TX) | 7 | ? | |
| 1921 | W | Orange HS (TX) | 21 | Kirbyville HS (TX) | 0 | ? | |
| 1921 | T | Orange HS (TX) | 7 | Sour Lake HS (TX) | 7 | ? | |
| 1921 | W | Orange HS (TX) | 33 | South Park HS | 0 | ? | |
| 1921 | L | Orange HS Alumni (NJ) | 0 | Orange HS (NJ) | 18 | ? | |
| 1921 | L | Orangeburg HS (SC) | 0 | Charleston HS (SC) | 51 | ? | |
| 1921 | L | Ordway HS (CO) | 0 | La Junta HS (CO) | 26 | ? | |
| 1921 | L | Ordway HS (CO) | 0 | Pueblo Centennial HS (CO) | 27 | ? | |
| 1921 | L | Oregon | 0 | California | 39 | Berkeley, CA | |
| 1921 | W | Oregon | 47 | Hawaii | 0 | Honolulu, HI | |
| 1921 | T | Oregon | 7 | Idaho | 7 | Portland, OR | |
| 1921 | T | Oregon | 0 | Oregon St. | 0 | Eugene, OR | |
| 1921 | W | Oregon | 7 | Willamette (OR) | 3 | Salem, OR | |
| 1921 | T | Oregon | 7 | Washington St. | 7 | Pullman, WA | |
| 1921 | W | Oregon | 21 | Pacific (OR) | 7 | Forest Grove, OR | |
| 1921 | W | Oregon | 21 | Multnomah AC (OR) | 7 | Eugene, OR | |
| 1921 | T | Oregon St. | 0 | Oregon | 0 | Eugene, OR | |
| 1921 | W | Oregon St. | 68 | Oregon St. Freshmen | 7 | Corvallis, OR | |
| 1921 | L | Oregon St. | 0 | Southern California | 7 | Pasadena, CA | |
| 1921 | L | Oregon St. | 7 | Stanford (CA) | 14 | Stanford, CA | |
| 1921 | W | Oregon St. | 24 | Washington | 0 | Corvallis, OR | |
| 1921 | W | Oregon St. | 54 | Willamette (OR) | 0 | Salem, OR | |
| 1921 | W | Oregon St. | 68 | Chemawa Indian School (OR) | 0 | Corvallis, OR | |
| 1921 | T | Oregon St. | 7 | Multnomah AC (OR) | 7 | Corvallis, OR | |
| 1921 | L | Oregon St. | 3 | Washington St. | 7 | Corvallis, OR | |
| 1921 | L | Oregon St. Freshmen | 7 | Oregon St. | 68 | Corvallis, OR | |
| 1921 | L | Orlando American Legion (FL) | 6 | Rollins (FL) | 31 | Winter Park, FL | |
| 1921 | T | Orlando American Legion (FL) | 0 | Rollins (FL) | 0 | ? | |
| 1921 | L | Orlando American Legion (FL) | 0 | Stetson (FL) | 25 | ? | |
| 1921 | L | Orleans HS (NE) | 6 | Holdrege HS (NE) | 13 | ? | |
| 1921 | L | Orleans HS (NE) | 0 | Holdrege HS (NE) | 36 | ? | |
| 1921 | L | Orosi HS (CA) | 0 | Dinuba HS (CA) | 54 | ? | |
| 1921 | L | Ortonville HS (MN) | 0 | Montevideo HS (MN) | 80 | ? | |
| 1921 | W | Osage HS (IA) | 21 | Austin HS (MN) | 0 | ? | |
| 1921 | W | Osage HS (IA) | 14 | Charles City HS (IA) | 13 | ? | |
| 1921 | W | Osage HS (IA) | 38 | Cresco HS (IA) | 0 | ? | |
| 1921 | W | Osage HS (IA) | 28 | Iowa State Teachers College HS | 0 | ? | |
| 1921 | L | Osage HS (IA) | 0 | Mason City HS (IA) | 21 | ? | |
| 1921 | W | Osage HS (IA) | 19 | Nashua HS (IA) | 0 | ? | |
| 1921 | W | Osage HS (IA) | 42 | New Hampton HS (IA) | 0 | ? | |
| 1921 | W | Osage HS (IA) | 62 | Saint Ansgar HS (IA) | 0 | ? | |
| 1921 | W | Osage HS (IA) | 17 | Waterloo West HS (IA) | 0 | ? | |
| 1921 | L | Osakis HS (MN) | 0 | Glenwood HS (MN) | 20 | ? | |
| 1921 | L | Oswego HS (KS) | 0 | Independence HS (KS) | 41 | ? | |
| 1921 | L | Oswego St. (NY) | 0 | Rochester Tech (NY) | 13 | ? | |
| 1921 | L | Ottawa (KS) | 7 | Baker (KS) | 28 | Ottawa, KS | |
| 1921 | W | Ottawa (KS) | 14 | Benedictine (KS) | 0 | Atchison, KS | |
| 1921 | L | Ottawa (KS) | 0 | College of Emporia (KS) | 28 | Emporia, KS | |
| 1921 | W | Ottawa (KS) | 7 | McPherson (KS) | 0 | ? | |
| 1921 | W | Ottawa (KS) | 10 | Saint Mary's (KS) | 7 | Saint Mary's, KS | |
| 1921 | T | Ottawa (KS) | 0 | Washburn (KS) | 0 | Ottawa, KS | |
| 1921 | L | Ottawa (KS) | 0 | Pittsburg St. (KS) | 7 | Pittsburg, KS | |
| 1921 | L | Ottawa (KS) | 0 | Emporia St. (KS) | 26 | Ottawa, KS | |
| 1921 | L | Ottawa (KS) | 7 | Friends (KS) | 16 | Ottawa, KS | |
| 1921 | L | Ottawa HS (IL) | 0 | LaSalle-Peru HS (IL) | 21 | ? | |
| 1921 | L | Otterbein (OH) | 0 | Denison (OH) | 49 | Granville, OH | |
| 1921 | W | Otterbein (OH) | 13 | Heidelberg (OH) | 2 | ? | |
| 1921 | T | Otterbein (OH) | 0 | Hiram (OH) | 0 | Hiram, OH | |
| 1921 | T | Otterbein (OH) | 7 | Kenyon (OH) | 7 | Westerville, OH | |
| 1921 | L | Otterbein (OH) | 13 | Wilmington (OH) | 14 | ? | |
| 1921 | L | Otterbein (OH) | 0 | Miami (OH) | 21 | Oxford, OH | |
| 1921 | L | Otterbein (OH) | 0 | Ashland (OH) | 7 | ? | |
| 1921 | L | Otterbein (OH) | 0 | Wittenberg (OH) | 20 | Springfield, OH | |
| 1921 | L | Ottumwa HS (IA) | 0 | Cedar Rapids HS (IA) | 20 | ? | |
| 1921 | L | Ouachita Baptist (AR) | 0 | Arkansas | 28 | Little Rock, AR | |
| 1921 | W | Ouachita Baptist (AR) | 58 | Central Arkansas | 0 | Arkadelphia, AR | |
| 1921 | W | Ouachita Baptist (AR) | 14 | Henderson St. (AR) | 0 | Arkadelphia, AR | |
| 1921 | W | Ouachita Baptist (AR) | 16 | Little Rock College (AR) | 0 | Little Rock, AR | |
| 1921 | W | Ouachita Baptist (AR) | 40 | Southern Arkansas | 0 | Arkadelphia, AR | |
| 1921 | L | Ouachita Baptist (AR) | 0 | Louisiana Tech | 20 | Ruston, LA | |
| 1921 | L | Ouachita Baptist (AR) | 6 | Mississippi St. | 21 | Starkville, MS | |
| 1921 | W | Ouachita Baptist (AR) | 35 | Hendrix (AR) | 0 | Conway, AR | |
| 1921 | L | Ouachita Baptist JV (AR) | 7 | Pine Bluff HS (AR) | 39 | ? | |
| 1921 | L | Outlaws | 0 | Santa Ana HS (CA) | 34 | ? | |
| 1921 | T | Outrigger AC (HI) | 0 | Nevada | 0 | Honolulu, HI | |
| 1921 | T | Outrigger Canoe Club (HI) | 12 | Hawaii | 12 | Honolulu, HI | |
| 1921 | L | Owasso HS (OK) | 6 | Collinsville HS (OK) | 21 | ? | |
| 1921 | W | Owatonna HS (MN) | 7 | Austin HS (MN) | 0 | ? | |
| 1921 | L | Owatonna HS (MN) | 0 | Faribault HS (MN) | 7 | ? | |
| 1921 | W | Owatonna HS (MN) | 12 | Kasson HS (MN) | 3 | ? | |
| 1921 | L | Owatonna HS (MN) | 0 | Mankato HS (MN) | 40 | ? | |
| 1921 | T | Owatonna HS (MN) | 0 | Northfield HS (MN) | 0 | ? | |
| 1921 | W | Owatonna HS (MN) | 27 | Pillsbury Military Academy (MN) | 0 | ? | |
| 1921 | L | Owatonna HS (MN) | 13 | Shattuck School (MN) | 14 | ? | |
| 1921 | L | Owensboro HS (KY) | 0 | Louisville HS (KY) | 21 | ? | |
| 1921 | L | Owosso HS (MI) | 0 | Saginaw Arthur Hill HS (MI) | 64 | ? | |
| 1921 | L | Owosso HS (MI) | 12 | Saginaw East HS (MI) | 20 | ? | |
| 1921 | L | Oxford HS (MS) | 13 | Grenada HS (MS) | 19 | ? | |
| 1921 | L | Oxford HS (NC) | 0 | Durham HS (NC) | 31 | ? | |
| 1921 | L | Oxford HS (NC) | 0 | Durham HS (NC) | 7 | ? | |
| 1921 | W | Oxford HS (NC) | 7 | Smithfield HS (NC) | 0 | ? | |
| 1921 | L | Oxford HS (NE) | 0 | Holdrege HS (NE) | 27 | ? | |
| 1921 | L | Oyster Bay HS (NY) | 0 | Port Washington HS (NY) | 34 | ? | |
| 1921 | L | Ozark HS (AR) | 0 | Russellville HS (AR) | 91 | ? | |
| 1921 | L | Ozark HS (AR) | 0 | Russellville HS (AR) | 97 | ? | |
| 1921 | L | Ozark HS (AR) | 0 | Van Buren HS (AR) | 75 | ? | |
| 1921 | L | Ozark Wesleyan (MO) | 13 | Drury (MO) | 34 | Marionville, MO | |
| 1921 | L | Ozarks (AR) | 0 | Arkansas Tech | 25 | Clarksville, AR | |
| 1921 | L | Ozarks (AR) | 0 | Hendrix (AR) | 20 | Clarksville, AR | |
| 1921 | W | Ozarks (AR) | 19 | Little Rock College (AR) | 13 | Clarksville, AR | |
| 1921 | T | Ozarks (AR) | 7 | Henderson St. (AR) | 7 | Clarksville, AR | |
| 1921 | W | Ozarks (AR) | 14 | Central Arkansas | 0 | Conway, AR | |
| 1921 | W | Pacific (CA) | 28 | Cal St.-Chico | 0 | Stockton, CA | |
| 1921 | L | Pacific (CA) | 0 | California Freshmen | 42 | ? | |
| 1921 | W | Pacific (CA) | 35 | Fresno St. (CA) | 0 | Stockton, CA | |
| 1921 | L | Pacific (CA) | 14 | Mare Island Marines (CA) | 39 | ? | |
| 1921 | W | Pacific (CA) | 34 | San Jose St. (CA) | 0 | Stockton, CA | |
| 1921 | L | Pacific (CA) | 6 | Stanford Freshmen (CA) | 49 | Stanford, CA | |
| 1921 | W | Pacific (OR) | 14 | Chemawa Indian School (OR) | 0 | Forest Grove, OR | |
| 1921 | W | Pacific (OR) | 28 | Lewis & Clark (OR) | 7 | Albany, OR | |
| 1921 | W | Pacific (OR) | 20 | Mount Angel (OR) | 6 | ? | |
| 1921 | W | Pacific (OR) | 27 | Willamette (OR) | 10 | ? | |
| 1921 | L | Pacific (OR) | 7 | Oregon | 21 | Forest Grove, OR | |
| 1921 | W | Pacific (OR) | 21 | Puget Sound (WA) | 14 | Tacoma, WA | |
| 1921 | L | Pacific Fleet (CA) | 10 | California | 21 | Berkeley, CA | |
| 1921 | W | Pacific Fleet (CA) | 20 | Saint Mary's (CA) | 0 | ? | |
| 1921 | W | Pacific Fleet (CA) | 27 | Stanford (CA) | 7 | Stanford, CA | |
| 1921 | W | Pacific Fleet (CA) | 14 | Nevada | 13 | Reno, NV | |
| 1921 | L | Pacific Grove HS (CA) | 0 | Salinas HS (CA) | 12 | ? | |
| 1921 | L | Pacific Grove HS (CA) | 6 | Santa Cruz HS (CA) | 39 | ? | |
| 1921 | L | Paine (GA) | 0 | Tuskegee (AL) | 21 | ? | |
| 1921 | L | Paint Lick Military Prep School (KY) | 0 | Eastern Kentucky | 7 | Richmond, KY | |
| 1921 | L | Paintsville HS (KY) | 0 | Ceredo-Kenova HS (WV) | 30 | ? | |
| 1921 | L | Palama | 6 | Hawaii | 13 | Honolulu, HI | |
| 1921 | L | Palmer College of Chiropractic (IA) | 0 | Benedictine (IL) | 103 | ? | |
| 1921 | L | Palmer College of Chiropractic (IA) | 0 | Lombard (IL) | 103 | ? | |
| 1921 | L | Palmer College of Chiropractic (IA) | 7 | Northwest Missouri St. | 9 | ? | |
| 1921 | L | Palmer College of Chiropractic (IA) | 0 | Dubuque (IA) | 70 | Dubuque, IA | |
| 1921 | L | Palmer HS (MA) | 0 | Ansonia HS (CT) | 83 | ? | |
| 1921 | L | Palmyra HS (MO) | 0 | Hannibal HS (MO) | 28 | ? | |
| 1921 | L | Palmyra HS (MO) | 0 | Pittsfield HS (IL) | 14 | ? | |
| 1921 | T | Palmyra HS (NJ) | 0 | Bordentown Manual Training (NJ) | 0 | ? | |
| 1921 | W | Palmyra HS (NJ) | 26 | Bristol HS (PA) | 0 | ? | |
| 1921 | T | Palmyra HS (NJ) | 7 | Burlington HS (NJ) | 7 | ? | |
| 1921 | W | Palmyra HS (NJ) | 13 | Burlington HS (NJ) | 7 | ? | |
| 1921 | W | Palmyra HS (NJ) | 27 | Burlington HS (NJ) | 7 | ? | |
| 1921 | W | Palmyra HS (NJ) | 12 | Gloucester HS (MA) | 2 | ? | |
| 1921 | W | Palmyra HS (NJ) | 7 | Haddon Heights HS (NJ) | 6 | ? | |
| 1921 | L | Palmyra HS (NJ) | 7 | Lansdale HS (PA) | 28 | ? | |
| 1921 | W | Palmyra HS (NJ) | 75 | Merchantville HS (NJ) | 0 | ? | |
| 1921 | W | Palmyra HS (NJ) | 21 | Moorestown Friends School (NJ) | 14 | ? | |
| 1921 | W | Palmyra HS (NJ) | 21 | Mount Holly HS (NJ) | 14 | ? | |
| 1921 | W | Palmyra HS (NJ) | 18 | Mount Holly HS (NJ) | 0 | ? | |
| 1921 | T | Palmyra HS (NJ) | 6 | Princeton HS (NJ) | 6 | ? | |
| 1921 | W | Palmyra HS (NJ) | 33 | Upper Darby HS (PA) | 6 | ? | |
| 1921 | L | Palmyra HS (NJ) | 3 | West Chester HS (PA) | 32 | ? | |
| 1921 | W | Palmyra HS (PA) | 26 | Bristol HS (PA) | 0 | ? | |
| 1921 | T | Palmyra HS (PA) | 7 | Burlington HS (NJ) | 7 | ? | |
| 1921 | W | Palmyra HS (PA) | 13 | Burlington HS (NJ) | 7 | ? | |
| 1921 | W | Palmyra HS (PA) | 27 | Burlington HS (NJ) | 7 | ? | |
| 1921 | L | Palo Alto HS (CA) | 0 | Berkeley HS (CA) | 42 | ? | |
| 1921 | W | Palo Alto HS (CA) | 7 | Mountain View HS (CA) | 0 | ? | |
| 1921 | W | Palo Alto HS (CA) | 7 | Salinas HS (CA) | 6 | ? | |
| 1921 | W | Palo Alto HS (CA) | 14 | San Francisco Lick Wilmerding HS (CA) | 7 | ? | |
| 1921 | W | Palo Alto HS (CA) | 12 | San Jose HS (CA) | 8 | ? | |
| 1921 | W | Palo Alto HS (CA) | 21 | San Mateo HS (CA) | 7 | ? | |
| 1921 | W | Palo Alto HS (CA) | 42 | Santa Clara HS (CA) | 0 | ? | |
| 1921 | W | Palo Alto HS (CA) | 38 | Sequoia HS | 7 | ? | |
| 1921 | W | Palo Alto HS (CA) | 42 | South City HS | 7 | ? | |
| 1921 | W | Palo Alto HS (CA) | 30 | William Warren Military School (CA) | 0 | ? | |
| 1921 | L | Paonia HS (CO) | 0 | Gunnison HS (CO) | 21 | ? | |
| 1921 | L | Paonia HS (CO) | 7 | Olathe HS (CO) | 27 | ? | |
| 1921 | L | Park City HS (UT) | 0 | Ogden HS (UT) | 35 | ? | |
| 1921 | L | Park City HS (UT) | 7 | Salt Lake City East Side HS (UT) | 55 | ? | |
| 1921 | W | Park City HS (UT) | 6 | Westminster College (UT) | 0 | ? | |
| 1921 | W | Park County HS (MT) | 60 | Belgrade HS (MT) | 0 | ? | |
| 1921 | W | Park County HS (MT) | 59 | Columbus HS (MT) | 0 | ? | |
| 1921 | L | Park County HS (MT) | 0 | Gallatin County HS (MT) | 26 | ? | |
| 1921 | W | Park County HS (MT) | 6 | Livingston Independents (MT) | 0 | ? | |
| 1921 | W | Park County HS (MT) | 61 | Whitehall HS (MT) | 0 | ? | |
| 1921 | W | Park County HS (MT) | 26 | Whitehall HS (MT) | 6 | ? | |
| 1921 | L | Park Rapids HS (MN) | 0 | Wadena HS (MN) | 27 | ? | |
| 1921 | L | Park Ridge HS (NJ) | 19 | Clifton HS (NJ) | 26 | ? | |
| 1921 | L | Park Ridge HS (NJ) | 0 | Newman School (NJ) | 7 | ? | |
| 1921 | L | Park Ridge HS (NJ) | 7 | Nyack HS (NY) | 19 | ? | |
| 1921 | L | Park Ridge HS (NJ) | 0 | Nyack HS (NY) | 12 | ? | |
| 1921 | W | Park Ridge HS (NJ) | 26 | Ramsey HS (NJ) | 3 | ? | |
| 1921 | W | Park Ridge HS (NJ) | 6 | Ramsey HS (NJ) | 3 | ? | |
| 1921 | L | Parker College (MN) | 0 | Gustavus Adolphus (MN) | 7 | Saint Peter, MN | |
| 1921 | W | Parkersburg HS (WV) | 47 | Charleston HS (WV) | 7 | ? | |
| 1921 | W | Parkersburg HS (WV) | 61 | Elkins HS (WV) | 0 | ? | |
| 1921 | W | Parkersburg HS (WV) | 41 | Fairmont HS (WV) | 0 | ? | |
| 1921 | W | Parkersburg HS (WV) | 27 | Huntington HS (WV) | 6 | ? | |
| 1921 | W | Parkersburg HS (WV) | 35 | Marietta HS (OH) | 6 | ? | |
| 1921 | W | Parkersburg HS (WV) | 7 | Marietta HS (OH) | 0 | ? | |
| 1921 | W | Parkersburg HS (WV) | 53 | Moundsville HS (WV) | 3 | ? | |
| 1921 | W | Parkersburg HS (WV) | 39 | Pennsboro HS (WV) | 0 | ? | |
| 1921 | W | Parkersburg HS (WV) | 6 | Wheeling HS (WV) | 0 | ? | |
| 1921 | L | Parkesburg HS (PA) | 6 | West Chester HS (PA) | 47 | ? | |
| 1921 | L | Parnassus HS | 0 | Rochester HS (PA) | 47 | ? | |
| 1921 | L | Parris Island Marines (SC) | 0 | Citadel (SC) | 37 | Charleston, SC | |
| 1921 | L | Parsons (IA) | 0 | Iowa Wesleyan | 7 | Fairfield, IA | |
| 1921 | L | Parsons (IA) | 0 | Simpson (IA) | 7 | Indianola, IA | |
| 1921 | W | Parsons (IA) | 3 | Tarkio (MO) | 0 | Fairfield, IA | |
| 1921 | L | Parsons (IA) | 0 | William Penn (IA) | 3 | Fairfield, IA | |
| 1921 | L | Parsons (IA) | 0 | Des Moines (IA) | 34 | Des Moines, IA | |
| 1921 | L | Parsons (IA) | 7 | Northern Iowa | 19 | Cedar Falls, IA | |
| 1921 | L | Parsons (IA) | 14 | Augustana (IL) | 28 | Rock Island, IL | |
| 1921 | L | Parsons HS (WV) | 0 | Elkins HS (WV) | 20 | ? | |
| 1921 | W | Parsons HS (WV) | 37 | Thomas HS (WV) | 0 | ? | |
| 1921 | W | Parsons HS (WV) | 63 | Thomas HS (WV) | 0 | ? | |
| 1921 | W | Pasadena HS (CA) | 7 | Los Angeles Hollywood HS (CA) | 0 | ? | |
| 1921 | L | Pasadena HS (CA) | 12 | Los Angeles HS (CA) | 26 | ? | |
| 1921 | L | Pasadena HS (CA) | 7 | Los Angeles Jefferson HS (CA) | 20 | ? | |
| 1921 | L | Pasadena HS (CA) | 14 | Los Angeles Lincoln HS (CA) | 21 | ? | |
| 1921 | L | Pasadena HS (CA) | 3 | Los Angeles Manual Arts HS (CA) | 21 | ? | |
| 1921 | W | Pasadena HS (CA) | 30 | Los Angeles Poly HS (CA) | 6 | ? | |
| 1921 | L | Pasadena HS (CA) | 0 | Santa Ana HS (CA) | 3 | ? | |
| 1921 | W | Paso Robles HS (CA) | 7 | Cal Poly-San Luis Obispo | 6 | San Luis Obispo, CA | |
| 1921 | L | Passaic HS (NJ) | 0 | Bloomfield HS (NJ) | 19 | ? | |
| 1921 | W | Passaic HS (NJ) | 23 | Cliffside Park HS (NJ) | 10 | ? | |
| 1921 | L | Passaic HS (NJ) | 3 | Englewood HS (NJ) | 7 | ? | |
| 1921 | W | Passaic HS (NJ) | 7 | Hackensack HS (NJ) | 0 | ? | |
| 1921 | W | Passaic HS (NJ) | 14 | New Brunswick HS (NJ) | 13 | ? | |
| 1921 | W | Passaic HS (NJ) | 23 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | W | Passaic HS (NJ) | 14 | Nutley HS (NJ) | 6 | ? | |
| 1921 | T | Passaic HS (NJ) | 7 | Paterson HS (NJ) | 7 | ? | |
| 1921 | L | Passaic HS (NJ) | 7 | Ridgewood HS (NJ) | 14 | ? | |
| 1921 | L | Passaic HS (NJ) | 0 | Rutherford HS (NJ) | 34 | ? | |
| 1921 | L | Paterson HS (NJ) | 0 | Dewitt Clinton HS (NY) | 14 | ? | |
| 1921 | W | Paterson HS (NJ) | 7 | Hackensack HS (NJ) | 0 | ? | |
| 1921 | T | Paterson HS (NJ) | 0 | Newark Barringer HS (NJ) | 0 | ? | |
| 1921 | T | Paterson HS (NJ) | 7 | Passaic HS (NJ) | 7 | ? | |
| 1921 | L | Paterson HS (NJ) | 0 | Paterson HS Alumni (NJ) | 6 | ? | |
| 1921 | L | Paterson HS (NJ) | 0 | Ridgewood HS (NJ) | 7 | ? | |
| 1921 | W | Paterson HS (NJ) | 14 | Saint Peter's Prep (NJ) | 13 | ? | |
| 1921 | L | Paterson HS (NJ) | 0 | Stuyvesant HS (NY) | 13 | ? | |
| 1921 | W | Paterson HS Alumni (NJ) | 6 | Paterson HS (NJ) | 0 | ? | |
| 1921 | L | Patterson HS (LA) | 0 | Louisiana-Lafayette | 26 | Patterson, LA | |
| 1921 | L | Paul Quinn (TX) | 10 | Wiley (TX) | 14 | Waco, TX | |
| 1921 | L | Paulsboro HS (NJ) | 6 | Glassboro HS (NJ) | 99 | ? | |
| 1921 | L | Pawling School (NY) | 0 | Choate School | 49 | ? | |
| 1921 | L | Pawling School (NY) | 3 | Eastman Business College (NY) | 6 | ? | |
| 1921 | L | Pawling School (NY) | 7 | Kent School (CT) | 13 | ? | |
| 1921 | T | Pawling School (NY) | 0 | Milford Academy (NY) | 0 | ? | |
| 1921 | L | Pawling School (NY) | 0 | Salisbury HS (CT) | 69 | ? | |
| 1921 | T | Pawling School (NY) | 0 | Taft School (CT) | 0 | ? | |
| 1921 | L | Pawtucket HS (RI) | 6 | Fall River Durfee HS (MA) | 13 | ? | |
| 1921 | L | Payson HS (UT) | 0 | Salt Lake City East Side HS (UT) | 56 | ? | |
| 1921 | L | Peabody HS | 0 | Nashville Hume-Fogg HS (TN) | 20 | ? | |
| 1921 | W | Peabody HS (MA) | 7 | Beverly HS (MA) | 0 | ? | |
| 1921 | L | Peabody HS (MA) | 6 | Charleston HS (SC) | 13 | ? | |
| 1921 | W | Peabody HS (MA) | 1 | Chelsea HS (MA) | 0 | ? | |
| 1921 | W | Peabody HS (MA) | 52 | Gloucester HS (MA) | 0 | ? | |
| 1921 | W | Peabody HS (MA) | 21 | Lawrence HS (MA) | 0 | ? | |
| 1921 | W | Peabody HS (MA) | 21 | Lynn Classical HS (MA) | 0 | ? | |
| 1921 | W | Peabody HS (MA) | 21 | Lynn English HS (MA) | 0 | ? | |
| 1921 | W | Peabody HS (MA) | 14 | Marblehead HS (MA) | 7 | ? | |
| 1921 | W | Peabody HS (MA) | 21 | Revere HS (MA) | 0 | ? | |
| 1921 | W | Peabody HS (MA) | 12 | Salem HS (MA) | 0 | ? | |
| 1921 | W | Peabody HS (MA) | 35 | Swampscott HS (MA) | 7 | ? | |
| 1921 | W | Peabody HS (MA) | 34 | Winthrop HS (MA) | 0 | ? | |
| 1921 | W | Pearl Harbor Navy (HI) | 35 | Hawaii | 0 | Honolulu, HI | |
| 1921 | L | Peekskill Military Academy (NY) | 0 | Drum Hill HS (NY) | 38 | ? | |
| 1921 | W | Peekskill Military Academy (NY) | 6 | Eastman Business College (NY) | 0 | ? | |
| 1921 | W | Peekskill Military Academy (NY) | 68 | Massey School | 7 | ? | |
| 1921 | L | Peekskill Military Academy (NY) | 0 | Montclair Military Academy (NJ) | 20 | ? | |
| 1921 | W | Peekskill Military Academy (NY) | 25 | Mount Pleasant Military Academy (NY) | 7 | ? | |
| 1921 | W | Peekskill Military Academy (NY) | 20 | Oakside HS | 0 | ? | |
| 1921 | W | Peekskill Military Academy (NY) | 7 | Saint John's Prep (NY) | 0 | ? | |
| 1921 | L | Pekin HS (IL) | 0 | Lincoln HS (IL) | 20 | ? | |
| 1921 | L | Pelham Manor HS (NY) | 0 | Cliffside Park HS (NJ) | 73 | ? | |
| 1921 | L | Pen Argyl HS (PA) | 0 | Bethlehem HS (PA) | 82 | ? | |
| 1921 | W | Pendleton HS (OR) | 49 | Athena HS (OR) | 7 | ? | |
| 1921 | W | Pendleton HS (OR) | 13 | Baker HS (OR) | 0 | ? | |
| 1921 | W | Pendleton HS (OR) | 42 | Enterprise HS (OR) | 3 | ? | |
| 1921 | W | Pendleton HS (OR) | 7 | Kennewick HS (WA) | 3 | ? | |
| 1921 | W | Pendleton HS (OR) | 13 | La Grande HS (OR) | 0 | ? | |
| 1921 | W | Pendleton HS (OR) | 20 | Milton HS (OR) | 13 | ? | |
| 1921 | W | Pendleton HS (OR) | 21 | The Dalles HS (OR) | 0 | ? | |
| 1921 | L | Pendleton HS (OR) | 0 | Walla Walla HS (WA) | 6 | ? | |
| 1921 | W | Penn Charter School (PA) | 27 | Chestnut Hill Academy (PA) | 7 | ? | |
| 1921 | W | Penn Charter School (PA) | 12 | Episcopal Academy (PA) | 0 | ? | |
| 1921 | W | Penn Charter School (PA) | 20 | Germantown Academy (PA) | 0 | ? | |
| 1921 | W | Penn Charter School (PA) | 13 | Haverford College Grammer School (PA) | 7 | ? | |
| 1921 | W | Penn Charter School (PA) | 7 | Lansdowne HS (PA) | 6 | ? | |
| 1921 | W | Penn Charter School (PA) | 13 | Philadelphia Central HS (PA) | 7 | ? | |
| 1921 | L | Penn Charter School (PA) | 0 | Radnor HS (PA) | 7 | ? | |
| 1921 | W | Penn Charter School (PA) | 61 | Saint Luke's School (PA) | 0 | ? | |
| 1921 | L | Penn Charter School (PA) | 0 | Swarthmore Prep School (PA) | 7 | ? | |
| 1921 | W | Penn St. | 28 | Georgia Tech | 7 | New York, NY | |
| 1921 | T | Penn St. | 21 | Harvard (MA) | 21 | Cambridge, MA | |
| 1921 | W | Penn St. | 53 | Lebanon Valley (PA) | 0 | State College, PA | |
| 1921 | W | Penn St. | 28 | Lehigh (PA) | 7 | State College, PA | |
| 1921 | T | Penn St. | 0 | Pittsburgh (PA) | 0 | Pittsburgh, PA | |
| 1921 | W | Penn St. | 24 | Gettysburg (PA) | 0 | State College, PA | |
| 1921 | W | Penn St. | 21 | Washington | 7 | Seattle, WA | |
| 1921 | W | Penn St. | 28 | Carnegie Mellon (PA) | 7 | State College, PA | |
| 1921 | W | Penn St. | 35 | North Carolina St. | 0 | State College, PA | |
| 1921 | W | Penn St. | 13 | Navy (MD) | 7 | Philadelphia, PA | |
| 1921 | W | Penn St. Freshmen | 13 | Bellefonte Academy (PA) | 0 | ? | |
| 1921 | T | Penn St. Freshmen | 0 | Kiski Academy (PA) | 0 | ? | |
| 1921 | W | Penn St. Freshmen | 49 | Mansfield (PA) | 0 | State College, PA | |
| 1921 | W | Penn St. Freshmen | 19 | Mercersburg Academy (PA) | 0 | ? | |
| 1921 | L | Pennington Seminary (NJ) | 0 | Bethlehem Prep School (PA) | 7 | ? | |
| 1921 | T | Pennington Seminary (NJ) | 0 | Blair Hall Academy (NJ) | 0 | ? | |
| 1921 | L | Pennington Seminary (NJ) | 0 | Delaware Valley (PA) | 1 | ? | Pennington Seminary Forfeits |
| 1921 | W | Pennington Seminary (NJ) | 27 | Rider-Moore Business College (NJ) | 0 | ? | |
| 1921 | L | Pennington Seminary (NJ) | 7 | Saint Benedict Prep School (NJ) | 13 | ? | |
| 1921 | L | Pennington Seminary (NJ) | 0 | Swarthmore Prep School (PA) | 41 | ? | |
| 1921 | T | Pennington Seminary (NJ) | 0 | Wenonah Military Academy (NJ) | 0 | ? | |
| 1921 | T | Pennington Seminary (NJ) | 7 | Williamson Trade School (PA) | 7 | ? | |
| 1921 | L | Pennington Seminary (NJ) | 0 | Bordentown Military Institute (NJ) | 6 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 13 | Bridgeton HS (NJ) | 7 | ? | |
| 1921 | L | Penns Grove HS (NJ) | 7 | Collingswood HS (NJ) | 23 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 21 | Glassboro HS (NJ) | 0 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 7 | Haddon Heights HS (NJ) | 0 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 21 | Millville HS (NJ) | 0 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 44 | New Castle HS (PA) | 0 | ? | |
| 1921 | T | Penns Grove HS (NJ) | 14 | Salem HS (NJ) | 14 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 39 | Salem HS (NJ) | 6 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 6 | Vineland HS (NJ) | 0 | ? | |
| 1921 | W | Penns Grove HS (NJ) | 45 | Woodstown HS (NJ) | 7 | ? | |
| 1921 | L | Pennsboro HS (WV) | 0 | Buckhannon HS (WV) | 34 | ? | |
| 1921 | W | Pennsboro HS (WV) | 24 | Morgantown HS (WV) | 7 | ? | |
| 1921 | L | Pennsboro HS (WV) | 0 | Parkersburg HS (WV) | 39 | ? | |
| 1921 | L | Pennsboro HS (WV) | 0 | Washington Irving HS (WV) | 13 | ? | |
| 1921 | L | Pennsylvania | 0 | Cornell (NY) | 41 | Philadelphia, PA | |
| 1921 | W | Pennsylvania | 89 | Delaware | 0 | Philadelphia, PA | |
| 1921 | L | Pennsylvania | 0 | Pittsburgh (PA) | 28 | Philadelphia, PA | |
| 1921 | T | Pennsylvania | 7 | Swarthmore (PA) | 7 | Philadelphia, PA | |
| 1921 | W | Pennsylvania | 21 | Virginia Military Institute | 7 | Philadelphia, PA | |
| 1921 | W | Pennsylvania | 20 | Franklin & Marshall (PA) | 0 | Philadelphia, PA | |
| 1921 | L | Pennsylvania | 6 | Lafayette (PA) | 38 | Philadelphia, PA | |
| 1921 | W | Pennsylvania | 7 | Gettysburg (PA) | 0 | Philadelphia, PA | |
| 1921 | T | Pennsylvania | 14 | Dartmouth (NH) | 14 | Hanover, NH | |
| 1921 | W | Pennsylvania Freshmen | 33 | Blair Hall (NJ) | 0 | ? | |
| 1921 | L | Pennsylvania Freshmen | 0 | Mercersburg Academy (PA) | 27 | ? | |
| 1921 | W | Pennsylvania Freshmen | 32 | Perkiomen Seminary (PA) | 7 | ? | |
| 1921 | W | Pennsylvania Freshmen | 24 | West Chester (PA) | 7 | Philadelphia, PA | |
| 1921 | L | Pennsylvania Institution for the Deaf | 7 | Bryn Athyn Academy (PA) | 21 | ? | |
| 1921 | W | Pennsylvania Institution for the Deaf | 27 | Chestnut Hill Academy (PA) | 6 | ? | |
| 1921 | T | Pennsylvania Institution for the Deaf | 28 | Coatesville HS (PA) | 28 | ? | |
| 1921 | L | Pennsylvania Institution for the Deaf | 0 | Delaware Valley (PA) | 27 | ? | |
| 1921 | W | Pennsylvania Institution for the Deaf | 55 | Downingtown HS (PA) | 0 | ? | |
| 1921 | L | Pennsylvania Institution for the Deaf | 0 | New Jersey (NJ) | 27 | ? | |
| 1921 | W | Pennsylvania Institution for the Deaf | 69 | Philadelphia South HS (PA) | 0 | ? | |
| 1921 | W | Pennsylvania Institution for the Deaf | 104 | Saint Luke's School (PA) | 0 | ? | |
| 1921 | W | Pennsylvania Institution for the Deaf | 98 | Williamson Trade School JV (PA) | 0 | ? | |
| 1921 | W | Pennsylvania Institution for the Deaf | 28 | Wilmington HS (DE) | 0 | ? | |
| 1921 | W | Peoria Central HS (IL) | 6 | Bloomington HS (IL) | 0 | ? | |
| 1921 | W | Peoria Central HS (IL) | 66 | Clinton HS (IL) | 0 | ? | |
| 1921 | W | Peoria Central HS (IL) | 45 | Decatur HS (IL) | 6 | ? | |
| 1921 | W | Peoria Central HS (IL) | 16 | LaSalle-Peru HS (IL) | 0 | ? | |
| 1921 | L | Peoria Central HS (IL) | 0 | Moline HS (IL) | 9 | ? | |
| 1921 | W | Peoria Central HS (IL) | 27 | Peoria Manual HS (IL) | 0 | ? | |
| 1921 | W | Peoria Manual HS (IL) | 21 | Jacksonville HS (IL) | 14 | ? | |
| 1921 | L | Peoria Manual HS (IL) | 0 | Peoria Central HS (IL) | 27 | ? | |
| 1921 | T | Perkasie HS (PA) | 7 | Quakertown HS (PA) | 7 | ? | |
| 1921 | W | Perkiomen Seminary (PA) | 15 | Bethlehem Prep School (PA) | 6 | ? | |
| 1921 | L | Perkiomen Seminary (PA) | 0 | Harrisburg Tech HS (PA) | 70 | ? | |
| 1921 | L | Perkiomen Seminary (PA) | 6 | Lawrenceville School (NJ) | 33 | ? | |
| 1921 | L | Perkiomen Seminary (PA) | 7 | Pennsylvania Freshmen | 32 | ? | |
| 1921 | W | Perkiomen Seminary (PA) | 51 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | L | Perkiomen Seminary (PA) | 7 | West Chester (PA) | 21 | ? | |
| 1921 | L | Perkiomen Seminary (PA) | 0 | Wyoming Seminary (PA) | 55 | ? | |
| 1921 | L | Perkiomen Seminary (PA) | 0 | Hill School (PA) | 42 | Pottstown, PA | |
| 1921 | L | Perryville HS (MO) | 0 | Marvin College (MO) | 53 | ? | |
| 1921 | L | Perryville HS (MO) | 0 | Marvin College (MO) | 1 | ? | Perryville HS Forfetis |
| 1921 | W | Peru HS (IN) | 27 | East Greenwich Academy (RI) | 0 | ? | |
| 1921 | L | Peru HS (IN) | 0 | Hope Street HS (RI) | 7 | ? | |
| 1921 | W | Peru HS (IN) | 12 | New Bedford HS (MA) | 0 | ? | |
| 1921 | W | Peru HS (IN) | 54 | Powder Point School | 0 | ? | |
| 1921 | W | Peru HS (IN) | 15 | Providence Tech HS (RI) | 7 | ? | |
| 1921 | W | Peru HS (IN) | 21 | Saint George HS | 7 | ? | |
| 1921 | W | Peru HS (IN) | 14 | Worcester North HS (MA) | 0 | ? | |
| 1921 | W | Peru St. (NE) | 28 | Cotner (NE) | 3 | ? | |
| 1921 | L | Peru St. (NE) | 0 | Doane (NE) | 3 | ? | |
| 1921 | W | Peru St. (NE) | 27 | Grand Island College (NE) | 0 | ? | |
| 1921 | W | Peru St. (NE) | 32 | Hastings (NE) | 7 | Peru, NE | |
| 1921 | W | Peru St. (NE) | 14 | Midland Lutheran (NE) | 0 | ? | |
| 1921 | W | Peru St. (NE) | 3 | Nebraska-Kearney | 0 | ? | |
| 1921 | L | Peru St. (NE) | 0 | Wayne St. (NE) | 6 | ? | |
| 1921 | L | Peru St. (NE) | 13 | York (NE) | 16 | ? | |
| 1921 | L | Petaluma HS (CA) | 0 | San Rafael HS (CA) | 47 | ? | |
| 1921 | W | Petaluma HS (CA) | 27 | San Rafael HS (CA) | 21 | ? | |
| 1921 | L | Petaluma HS (CA) | 0 | Santa Rosa HS (CA) | 33 | ? | |
| 1921 | L | Petaluma HS (CA) | 6 | Santa Rosa HS (CA) | 35 | ? | |
| 1921 | L | Petaluma HS (CA) | 7 | Tamalpais HS (CA) | 14 | ? | |
| 1921 | L | Petersburg HS (VA) | 0 | Newport News HS (VA) | 41 | ? | |
| 1921 | T | Phalen Luther Seminary (MN) | 7 | Bethel Academy | 7 | ? | |
| 1921 | W | Phalen Luther Seminary (MN) | 9 | Bethel Academy | 7 | ? | |
| 1921 | T | Phalen Luther Seminary (MN) | 0 | Saint Paul Academy (MN) | 0 | ? | |
| 1921 | L | Phalen Luther Seminary (MN) | 0 | Saint Paul Central HS (MN) | 38 | ? | |
| 1921 | L | Phalen Luther Seminary (MN) | 2 | Saint Paul Humboldt HS (MN) | 13 | ? | |
| 1921 | T | Phalen Luther Seminary (MN) | 6 | Saint Paul Johnson HS (MN) | 6 | ? | |
| 1921 | L | Phalen Luther Seminary (MN) | 13 | Wayzata HS (MN) | 21 | ? | |
| 1921 | L | Pharm. Mater | 0 | Staunton Military Academy (VA) | 41 | ? | |
| 1921 | L | Pheba HS (MS) | 0 | Ackerman HS (MS) | 21 | ? | |
| 1921 | L | Philadelphia Catholic HS (PA) | 0 | Haverhill Saint James HS (MA) | 20 | ? | |
| 1921 | W | Philadelphia Catholic HS (PA) | 14 | Philadelphia Southern Manual Training HS (PA) | 6 | ? | |
| 1921 | L | Philadelphia Catholic HS (PA) | 0 | Philadelphia West Catholic HS (PA) | 20 | ? | |
| 1921 | L | Philadelphia Catholic HS (PA) | 0 | Radnor HS (PA) | 21 | ? | |
| 1921 | L | Philadelphia Catholic HS (PA) | 0 | Saint Joseph's Prep School (PA) | 24 | ? | |
| 1921 | L | Philadelphia Catholic HS (PA) | 7 | Villanova Prep School (PA) | 13 | ? | |
| 1921 | W | Philadelphia Catholic HS (PA) | 6 | Washington Eastern HS (DC) | 0 | ? | |
| 1921 | W | Philadelphia Catholic HS (PA) | 6 | West Chester HS (PA) | 3 | ? | |
| 1921 | T | Philadelphia Central HS (PA) | 0 | Bryn Athyn Academy (PA) | 0 | ? | |
| 1921 | L | Philadelphia Central HS (PA) | 0 | Frankford HS (PA) | 13 | ? | |
| 1921 | W | Philadelphia Central HS (PA) | 14 | Germantown HS (PA) | 0 | ? | |
| 1921 | W | Philadelphia Central HS (PA) | 14 | Lower Merion HS (PA) | 0 | ? | |
| 1921 | L | Philadelphia Central HS (PA) | 7 | Penn Charter School (PA) | 13 | ? | |
| 1921 | W | Philadelphia Central HS (PA) | 20 | Philadelphia Northeast HS (PA) | 10 | ? | |
| 1921 | W | Philadelphia Central HS (PA) | 19 | Philadelphia Southern Manual Training HS (PA) | 10 | ? | |
| 1921 | L | Philadelphia Central HS (PA) | 0 | Philadelphia West HS (PA) | 14 | ? | |
| 1921 | L | Philadelphia Northeast HS (PA) | 6 | Camden HS (NJ) | 7 | ? | |
| 1921 | L | Philadelphia Northeast HS (PA) | 0 | Frankford HS (PA) | 32 | ? | |
| 1921 | L | Philadelphia Northeast HS (PA) | 3 | Germantown HS (PA) | 24 | ? | |
| 1921 | L | Philadelphia Northeast HS (PA) | 10 | Philadelphia Central HS (PA) | 20 | ? | |
| 1921 | W | Philadelphia Northeast HS (PA) | 33 | Philadelphia South HS (PA) | 0 | ? | |
| 1921 | L | Philadelphia Northeast HS (PA) | 7 | Philadelphia West HS (PA) | 26 | ? | |
| 1921 | L | Philadelphia Northeast HS (PA) | 0 | Tome Institute (MD) | 12 | ? | |
| 1921 | L | Philadelphia Northeast HS (PA) | 7 | Williamson Trade School (PA) | 13 | ? | |
| 1921 | L | Philadelphia South HS (PA) | 0 | Pennsylvania Institution for the Deaf | 69 | ? | |
| 1921 | L | Philadelphia South HS (PA) | 0 | Philadelphia Northeast HS (PA) | 33 | ? | |
| 1921 | L | Philadelphia Southern Manual Training HS (PA) | 0 | Frankford HS (PA) | 38 | ? | |
| 1921 | L | Philadelphia Southern Manual Training HS (PA) | 0 | Germantown HS (PA) | 28 | ? | |
| 1921 | L | Philadelphia Southern Manual Training HS (PA) | 0 | La Salle Prep School (PA) | 15 | ? | |
| 1921 | L | Philadelphia Southern Manual Training HS (PA) | 6 | Philadelphia Catholic HS (PA) | 14 | ? | |
| 1921 | L | Philadelphia Southern Manual Training HS (PA) | 10 | Philadelphia Central HS (PA) | 19 | ? | |
| 1921 | L | Philadelphia Southern Manual Training HS (PA) | 7 | Philadelphia West HS (PA) | 49 | ? | |
| 1921 | T | Philadelphia West Catholic HS (PA) | 7 | Bryn Athyn HS (PA) | 7 | ? | |
| 1921 | W | Philadelphia West Catholic HS (PA) | 40 | Friends Central School (PA) | 0 | ? | |
| 1921 | W | Philadelphia West Catholic HS (PA) | 20 | Philadelphia Catholic HS (PA) | 0 | ? | |
| 1921 | W | Philadelphia West Catholic HS (PA) | 26 | Philadelphia West HS (PA) | 7 | ? | |
| 1921 | L | Philadelphia West Catholic HS (PA) | 6 | Saint Joseph's Prep School (PA) | 7 | ? | |
| 1921 | W | Philadelphia West Catholic HS (PA) | 28 | Tredyffun-Easttown HS (PA) | 7 | ? | |
| 1921 | W | Philadelphia West Catholic HS (PA) | 7 | Villanova Prep School (PA) | 6 | ? | |
| 1921 | L | Philadelphia West Catholic HS (PA) | 0 | Villanova Prep School (PA) | 7 | ? | |
| 1921 | T | Philadelphia West Catholic HS (PA) | 7 | Wenonah Military Academy (NJ) | 7 | ? | |
| 1921 | L | Philadelphia West HS (PA) | 12 | Bryn Athyn HS (PA) | 16 | ? | |
| 1921 | L | Philadelphia West HS (PA) | 0 | Frankford HS (PA) | 6 | ? | |
| 1921 | W | Philadelphia West HS (PA) | 13 | Germantown HS (PA) | 6 | ? | |
| 1921 | W | Philadelphia West HS (PA) | 14 | Philadelphia Central HS (PA) | 0 | ? | |
| 1921 | W | Philadelphia West HS (PA) | 26 | Philadelphia Northeast HS (PA) | 7 | ? | |
| 1921 | W | Philadelphia West HS (PA) | 49 | Philadelphia Southern Manual Training HS (PA) | 7 | ? | |
| 1921 | L | Philadelphia West HS (PA) | 7 | Philadelphia West Catholic HS (PA) | 26 | ? | |
| 1921 | L | Philadelphia West HS (PA) | 0 | Radnor HS (PA) | 6 | ? | |
| 1921 | L | Philander-Smith (AR) | 0 | Arkansas Baptist | 28 | ? | |
| 1921 | T | Philander-Smith (AR) | 0 | Arkansas-Pine Bluff | 0 | ? | |
| 1921 | W | Philander-Smith (AR) | 7 | Shorter College (AR) | 0 | ? | |
| 1921 | L | Philippi HS (WV) | 0 | Belington HS (WV) | 27 | ? | |
| 1921 | L | Philippi HS (WV) | 0 | Belington HS (WV) | 21 | ? | |
| 1921 | L | Phillips (OK) | 6 | Baylor (TX) | 34 | Waco, TX | |
| 1921 | W | Phillips (OK) | 9 | Hardin-Simmons (TX) | 0 | Abilene, TX | |
| 1921 | L | Phillips (OK) | 6 | Oklahoma St. | 7 | Enid, OK | |
| 1921 | T | Phillips (OK) | 0 | Texas Christian | 0 | Enid, OK | |
| 1921 | L | Phillips (OK) | 10 | Tulsa (OK) | 21 | Tulsa, OK | |
| 1921 | W | Phillips (OK) | 42 | Kingfisher (OK) | 7 | Enid, OK | |
| 1921 | L | Phillips (OK) | 3 | Central Oklahoma | 28 | Enid, OK | |
| 1921 | W | Phillips (OK) | 14 | Southwestern Oklahoma St. | 0 | Enid, OK | |
| 1921 | T | Phillips (OK) | 0 | Arkansas | 0 | Fayetteville, AR | |
| 1921 | W | Phillips Andover Academy (MA) | 28 | Worcester Academy (MA) | 13 | ? | |
| 1921 | L | Phillips Exeter Academy (NH) | 0 | Amesbury HS (MA) | 13 | ? | |
| 1921 | L | Phillips Exeter Academy (NH) | 6 | Dover HS (NH) | 7 | ? | |
| 1921 | W | Phillips Exeter Academy (NH) | 26 | Dover HS (NH) | 0 | ? | |
| 1921 | L | Phillips Exeter Academy (NH) | 0 | Newburyport HS (MA) | 7 | ? | |
| 1921 | W | Phillips Exeter Academy (NH) | 21 | Pinkerton Academy | 0 | ? | |
| 1921 | L | Phillips Exeter Academy (NH) | 0 | Portsmouth HS (NH) | 6 | ? | |
| 1921 | L | Phillips Exeter Academy (NH) | 0 | Punchard HS (MA) | 7 | ? | |
| 1921 | W | Phillips Exeter Academy (NH) | 7 | Rochester HS (NH) | 0 | ? | |
| 1921 | W | Phillips Exeter Academy (NH) | 41 | Sanborn Seminary (NH) | 0 | ? | |
| 1921 | W | Phillips Exeter Academy (NH) | 12 | Sanborn Seminary (NH) | 0 | ? | |
| 1921 | W | Phillips Exeter Academy (NH) | 8 | Ward Hill HS (MA) | 0 | ? | |
| 1921 | W | Phillips Exeter Academy (NH) | 13 | Worcester Academy (MA) | 0 | ? | |
| 1921 | L | Phillipsburg HS (NJ) | 7 | Blair Hall Academy (NJ) | 14 | ? | |
| 1921 | L | Phillipsburg HS (NJ) | 7 | Easton HS (PA) | 44 | ? | |
| 1921 | W | Phillipsburg HS (NJ) | 35 | Lambertville HS (NJ) | 0 | ? | |
| 1921 | L | Phillipsburg HS (NJ) | 0 | Newark Barringer HS (NJ) | 6 | ? | |
| 1921 | W | Phillipsburg HS (NJ) | 13 | Nutley HS (NJ) | 0 | ? | |
| 1921 | L | Phillipsburg HS (NJ) | 0 | Rutherford HS (NJ) | 42 | ? | |
| 1921 | L | Phillipsburg HS JV (NJ) | 0 | Hackettstown HS (NJ) | 14 | ? | |
| 1921 | W | Phoenix College (AZ) | 77 | Northern Arizona | 0 | Phoenix, AZ | |
| 1921 | L | Phoenix Indian School (AZ) | 0 | Arizona | 75 | Tucson, AZ | |
| 1921 | L | Phoenixville HS (PA) | 2 | Bethlehem HS (PA) | 17 | ? | |
| 1921 | L | Phoenixville HS (PA) | 0 | Coatesville HS (PA) | 14 | ? | |
| 1921 | W | Phoenixville HS (PA) | 6 | Norristown HS (PA) | 0 | ? | |
| 1921 | L | Phoenixville HS (PA) | 0 | Ridley Park HS (PA) | 6 | ? | |
| 1921 | W | Phoenixville HS (PA) | 21 | West Chester HS (PA) | 7 | ? | |
| 1921 | L | Piedmont (GA) | 0 | Clarkesville A&M School (GA) | 6 | ? | Clarkesville A&M School won - score unknown |
| 1921 | L | Piedmont (GA) | 6 | Fort Benning (GA) | 28 | ? | |
| 1921 | L | Piedmont (GA) | 0 | Georgia Freshmen | 26 | ? | |
| 1921 | L | Piedmont (GA) | 7 | Georgia Tech Freshmen | 21 | ? | |
| 1921 | W | Piedmont (GA) | 6 | Oglethorpe JV (GA) | 0 | ? | |
| 1921 | T | Piedmont HS (CA) | 0 | Potter School (CA) | 0 | ? | |
| 1921 | T | Piedmont HS (CA) | 7 | San Rafael HS (CA) | 7 | ? | |
| 1921 | T | Piedmont HS (CA) | 0 | Tamalpais HS (CA) | 0 | ? | |
| 1921 | L | Pillsbury Military Academy (MN) | 0 | Owatonna HS (MN) | 27 | ? | |
| 1921 | L | Pillsbury Military Academy (MN) | 0 | Rochester HS (MN) | 36 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 54 | Conway HS (AR) | 0 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 16 | Fordyce HS (AR) | 13 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 13 | Fordyce HS (AR) | 0 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 7 | Henderson St. JV (AR) | 6 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 48 | Hot Springs HS (AR) | 0 | ? | |
| 1921 | T | Pine Bluff HS (AR) | 0 | Lonoke HS (AR) | 0 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 39 | Ouachita Baptist JV (AR) | 7 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 42 | Shreveport HS (LA) | 7 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 41 | Texarkana HS (AR) | 0 | ? | |
| 1921 | W | Pine Bluff HS (AR) | 27 | Tupelo Military Institute (MS) | 0 | ? | |
| 1921 | W | Pine Island HS (MN) | 33 | Stewartville HS (MN) | 6 | ? | |
| 1921 | T | Pineland HS | 0 | Glassboro HS (NJ) | 0 | ? | |
| 1921 | L | Pineville HS (KY) | 14 | Elizabethtown HS (KY) | 28 | ? | |
| 1921 | W | Pingry School (NJ) | 1 | Clifton HS (NJ) | 0 | ? | |
| 1921 | W | Pingry School (NJ) | 62 | Cranford HS (NJ) | 0 | ? | |
| 1921 | W | Pingry School (NJ) | 27 | Metuchen HS (NJ) | 0 | ? | |
| 1921 | W | Pingry School (NJ) | 41 | Morristown HS (NJ) | 21 | ? | |
| 1921 | W | Pingry School (NJ) | 14 | Newman School (NJ) | 0 | ? | |
| 1921 | W | Pingry School (NJ) | 69 | Riverdale School (NJ) | 0 | ? | |
| 1921 | W | Pingry School (NJ) | 42 | Roselle Park HS (NJ) | 10 | ? | |
| 1921 | L | Pingry School JV (NJ) | 0 | Plainfield HS JV (NJ) | 6 | ? | |
| 1921 | L | Pio Nomo College (WI) | 0 | Saint Norbert (WI) | 38 | De Pere, WI | |
| 1921 | L | Pio Nono HS (WI) | 0 | Loyola Academy (IL) | 48 | ? | |
| 1921 | W | Pipestone HS (MN) | 42 | Brookings HS (SD) | 0 | ? | |
| 1921 | W | Pipestone HS (MN) | 6 | Flandreau HS (SD) | 0 | ? | |
| 1921 | W | Pipestone HS (MN) | 23 | Luverne HS (MN) | 0 | ? | |
| 1921 | L | Pipestone HS (MN) | 6 | Marshall HS (MN) | 21 | ? | |
| 1921 | W | Pipestone HS (MN) | 49 | Slayton HS (MN) | 0 | ? | |
| 1921 | W | Pipestone HS (MN) | 6 | Tracy HS (MN) | 0 | ? | |
| 1921 | T | Pipestone HS (MN) | 0 | Windom HS (MN) | 0 | ? | |
| 1921 | L | Pipestone HS (MN) | 0 | Worthington HS (MN) | 48 | ? | |
| 1921 | L | Pittsburg Academy | 0 | Johnstown HS (PA) | 28 | ? | |
| 1921 | T | Pittsburg St. (KS) | 0 | Baker (KS) | 0 | Baldwin City, KS | |
| 1921 | W | Pittsburg St. (KS) | 14 | College of Emporia (KS) | 10 | Emporia, KS | |
| 1921 | L | Pittsburg St. (KS) | 7 | Emporia St. (KS) | 27 | Pittsburg, KS | |
| 1921 | L | Pittsburg St. (KS) | 0 | Haskell Indian Nations (KS) | 14 | Pittsburg, KS | |
| 1921 | W | Pittsburg St. (KS) | 14 | Southwestern (KS) | 0 | Pittsburg, KS | |
| 1921 | W | Pittsburg St. (KS) | 39 | Carthage American Legion (MO) | 0 | Pittsburg, KS | |
| 1921 | W | Pittsburg St. (KS) | 7 | Ottawa (KS) | 0 | Pittsburg, KS | |
| 1921 | W | Pittsburg St. (KS) | 21 | Washburn (KS) | 7 | Topeka, KS | |
| 1921 | W | Pittsburg St. (KS) | 13 | Saint Mary's (KS) | 7 | Saint Mary's, KS | |
| 1921 | W | Pittsburg St. (KS) | 40 | Eastern Oklahoma St. | 0 | Pittsburg, KS | |
| 1921 | W | Pittsburgh (PA) | 21 | Cincinnati (OH) | 14 | Pittsburgh, PA | |
| 1921 | W | Pittsburgh (PA) | 28 | Geneva (PA) | 0 | Beaver Falls, PA | |
| 1921 | T | Pittsburgh (PA) | 0 | Penn St. | 0 | Pittsburgh, PA | |
| 1921 | W | Pittsburgh (PA) | 28 | Pennsylvania | 0 | Philadelphia, PA | |
| 1921 | W | Pittsburgh (PA) | 35 | Syracuse (NY) | 0 | Pittsburgh, PA | |
| 1921 | L | Pittsburgh (PA) | 0 | Lafayette (PA) | 6 | Easton, PA | |
| 1921 | L | Pittsburgh (PA) | 0 | Nebraska | 10 | Pittsburgh, PA | |
| 1921 | W | Pittsburgh (PA) | 21 | West Virginia | 14 | Pittsburgh, PA | |
| 1921 | L | Pittsburgh (PA) | 0 | Washington & Jefferson (PA) | 7 | Pittsburgh, PA | |
| 1921 | L | Pittsburgh 5th Ave. HS (PA) | 0 | Johnstown HS (PA) | 73 | ? | |
| 1921 | L | Pittsburgh 5th Ave. HS (PA) | 0 | Pittsburgh Allegheny HS (PA) | 55 | ? | |
| 1921 | L | Pittsburgh 5th Ave. HS (PA) | 0 | South Hills HS (PA) | 33 | ? | |
| 1921 | L | Pittsburgh 5th Ave. HS (PA) | 0 | Westinghouse HS (PA) | 51 | ? | |
| 1921 | L | Pittsburgh Academy (PA) | 0 | Shady Side Academy (PA) | 55 | ? | |
| 1921 | L | Pittsburgh Academy (PA) | 7 | Indiana (PA) | 15 | Indiana, PA | |
| 1921 | W | Pittsburgh Allegheny HS (PA) | 7 | Morgantown HS (WV) | 0 | ? | |
| 1921 | W | Pittsburgh Allegheny HS (PA) | 55 | Pittsburgh 5th Ave. HS (PA) | 0 | ? | |
| 1921 | L | Pittsburgh Allegheny HS (PA) | 0 | Pittsburgh Peabody HS (PA) | 6 | ? | |
| 1921 | W | Pittsburgh Allegheny HS (PA) | 27 | Pittsburgh South HS (PA) | 0 | ? | |
| 1921 | T | Pittsburgh Allegheny HS (PA) | 7 | Schenley HS (PA) | 7 | ? | |
| 1921 | T | Pittsburgh Allegheny HS (PA) | 13 | South Hills HS (PA) | 13 | ? | |
| 1921 | L | Pittsburgh Allegheny HS (PA) | 0 | Washington HS (PA) | 19 | ? | |
| 1921 | L | Pittsburgh Allegheny HS (PA) | 0 | Westinghouse HS (PA) | 6 | ? | |
| 1921 | W | Pittsburgh Freshmen (PA) | 28 | Bellefonte Academy (PA) | 0 | ? | |
| 1921 | W | Pittsburgh Freshmen (PA) | 9 | Kiski Academy (PA) | 0 | ? | |
| 1921 | W | Pittsburgh Freshmen (PA) | 26 | Slippery Rock (PA) | 0 | ? | |
| 1921 | W | Pittsburgh Peabody HS (PA) | 6 | Pittsburgh Allegheny HS (PA) | 0 | ? | |
| 1921 | W | Pittsburgh Peabody HS (PA) | 20 | South Hills HS (PA) | 0 | ? | |
| 1921 | L | Pittsburgh Peabody HS (PA) | 7 | Westinghouse HS (PA) | 13 | ? | |
| 1921 | L | Pittsburgh Peabody HS (PA) | 0 | Wilkinsburg HS (PA) | 6 | ? | |
| 1921 | L | Pittsburgh South HS (PA) | 0 | Pittsburgh Allegheny HS (PA) | 27 | ? | |
| 1921 | W | Pittsburgh South HS (PA) | 13 | South Hills HS (PA) | 0 | ? | |
| 1921 | L | Pittsburgh South HS (PA) | 0 | Westinghouse HS (PA) | 7 | ? | |
| 1921 | W | Pittsfield HS (IL) | 102 | Barry HS (IL) | 0 | ? | |
| 1921 | W | Pittsfield HS (IL) | 33 | Canton HS (IL) | 6 | ? | |
| 1921 | W | Pittsfield HS (IL) | 41 | Hannibal HS (MO) | 0 | ? | |
| 1921 | W | Pittsfield HS (IL) | 14 | Jacksonville HS (IL) | 7 | ? | |
| 1921 | W | Pittsfield HS (IL) | 14 | Palmyra HS (MO) | 0 | ? | |
| 1921 | W | Pittsfield HS (IL) | 36 | Quincy HS (IL) | 0 | ? | |
| 1921 | W | Pittsfield HS (IL) | 34 | Roodhouse HS (IL) | 0 | ? | |
| 1921 | L | Pittsfield HS (IL) | 6 | Waverly HS (IL) | 15 | ? | |
| 1921 | W | Pittsfield HS (IL) | 13 | White Hall HS (IL) | 12 | ? | |
| 1921 | W | Plainfield HS (NJ) | 24 | Battin HS (NJ) | 7 | ? | |
| 1921 | W | Plainfield HS (NJ) | 28 | Bayonne HS (NJ) | 0 | ? | |
| 1921 | W | Plainfield HS (NJ) | 7 | Bloomfield HS (NJ) | 0 | ? | |
| 1921 | W | Plainfield HS (NJ) | 42 | Irvington HS (NJ) | 0 | ? | |
| 1921 | T | Plainfield HS (NJ) | 7 | Montclair HS (NJ) | 7 | ? | |
| 1921 | L | Plainfield HS (NJ) | 7 | New Brunswick HS (NJ) | 14 | ? | |
| 1921 | W | Plainfield HS (NJ) | 41 | Newark South Side HS (NJ) | 0 | ? | |
| 1921 | W | Plainfield HS (NJ) | 28 | Westfield HS (NJ) | 0 | ? | |
| 1921 | T | Plainfield HS JV (NJ) | 0 | New Brunswick HS JV (NJ) | 0 | ? | |
| 1921 | W | Plainfield HS JV (NJ) | 6 | Nutley HS JV (NJ) | 0 | ? | |
| 1921 | W | Plainfield HS JV (NJ) | 6 | Pingry School JV (NJ) | 0 | ? | |
| 1921 | L | Plainwell HS (MI) | 0 | Grand Rapids Union HS (MI) | 32 | ? | |
| 1921 | L | Platte HS (SD) | 0 | Dallas HS (SD) | 88 | ? | |
| 1921 | L | Pleasantville HS (NJ) | 0 | Bridgeton HS (NJ) | 19 | ? | |
| 1921 | L | Pleasantville HS (NJ) | 0 | Hammonton HS (NJ) | 26 | ? | |
| 1921 | L | Pleasantville HS (NJ) | 21 | Hammonton HS (NJ) | 30 | ? | |
| 1921 | L | Pleasantville HS (NJ) | 6 | Horace Mann School (NY) | 38 | ? | |
| 1921 | T | Pleasantville HS (NJ) | 7 | Ocean City HS (NJ) | 7 | ? | |
| 1921 | W | Pleasantville HS (NJ) | 7 | Ocean City HS (NJ) | 0 | ? | |
| 1921 | L | Pleasantville HS (NJ) | 7 | Port Chester HS (NY) | 41 | ? | |
| 1921 | W | Pleasantville HS (NJ) | 21 | Wildwood HS (NJ) | 0 | ? | |
| 1921 | L | Pleasantville HS (NY) | 0 | Irving School (NY) | 19 | ? | |
| 1921 | W | Plymouth HS (PA) | 7 | Wilkes-Barre HS (PA) | 0 | ? | |
| 1921 | L | Plymouth HS (PA) | 0 | Williamsport HS (PA) | 51 | ? | |
| 1921 | L | Point Pleasant HS (NJ) | 0 | Clifton HS (NJ) | 2 | ? | |
| 1921 | L | Point Pleasant HS (NJ) | 6 | Lakewood HS (NJ) | 21 | ? | |
| 1921 | W | Point Pleasant HS (NJ) | 21 | Red Bank HS (NJ) | 0 | ? | |
| 1921 | W | Pomfret School (CT) | 7 | Choate School | 0 | ? | |
| 1921 | T | Pomfret School (CT) | 7 | Milford Academy (NY) | 7 | ? | |
| 1921 | W | Pomfret School (CT) | 14 | Milton Academy (MA) | 0 | ? | |
| 1921 | L | Pomfret School (CT) | 0 | Roxbury HS (MA) | 35 | ? | |
| 1921 | L | Pomfret School (CT) | 0 | Roxbury School (CT) | 35 | ? | |
| 1921 | L | Pomfret School (CT) | 10 | Taft School (CT) | 16 | ? | |
| 1921 | T | Pomfret School (CT) | 7 | Tufts Freshmen (MA) | 7 | ? | |
| 1921 | W | Pomfret School (CT) | 3 | Worcester Commerce HS (MA) | 0 | ? | |
| 1921 | W | Pomona HS (CA) | 7 | Chaffee HS (CA) | 3 | ? | |
| 1921 | L | Pomona HS (CA) | 0 | Kern County HS (CA) | 27 | ? | |
| 1921 | W | Pomona-Pitzer (CA) | 10 | California Tech | 0 | Pasadena, CA | |
| 1921 | T | Pomona-Pitzer (CA) | 7 | Occidental (CA) | 7 | Pomona, CA | |
| 1921 | L | Pomona-Pitzer (CA) | 7 | Southern California | 35 | Los Angeles, CA | |
| 1921 | W | Pomona-Pitzer (CA) | 55 | UCLA | 7 | Los Angeles, CA | |
| 1921 | L | Pomona-Pitzer (CA) | 7 | Redlands (CA) | 17 | Redlands, CA | |
| 1921 | L | Pomona-Pitzer (CA) | 9 | Whittier (CA) | 42 | Claremont, CA | |
| 1921 | T | Pontiac HS (MI) | 7 | Ann Arbor HS (MI) | 7 | ? | |
| 1921 | W | Pontiac HS (MI) | 28 | Detroit Central HS (MI) | 0 | ? | |
| 1921 | W | Pontiac HS (MI) | 7 | Flint Central HS (MI) | 6 | ? | |
| 1921 | W | Poplarville HS (MS) | 40 | Southern Mississippi | 0 | Hattiesburg, MS | |
| 1921 | L | Port Chester HS (NY) | 13 | Drum Hill HS (NY) | 26 | ? | |
| 1921 | T | Port Chester HS (NY) | 7 | Irving School (NY) | 7 | ? | |
| 1921 | W | Port Chester HS (NY) | 20 | Mamaroneck HS (NY) | 0 | ? | |
| 1921 | L | Port Chester HS (NY) | 12 | Meriden HS (CT) | 13 | ? | |
| 1921 | L | Port Chester HS (NY) | 0 | New Rochelle HS (NY) | 14 | ? | |
| 1921 | W | Port Chester HS (NY) | 41 | Norwalk HS (CT) | 0 | ? | |
| 1921 | W | Port Chester HS (NY) | 41 | Pleasantville HS (NJ) | 7 | ? | |
| 1921 | W | Port Chester HS (NY) | 18 | Rye HS (NY) | 0 | ? | |
| 1921 | W | Port Chester HS (NY) | 13 | Washington Irving HS | 0 | ? | |
| 1921 | L | Port Huron HS (MI) | 0 | Detroit Northwestern HS (MI) | 45 | ? | |
| 1921 | L | Port Huron HS (MI) | 0 | Saginaw Arthur Hill HS (MI) | 6 | ? | |
| 1921 | L | Port Huron HS (MI) | 7 | Saginaw East HS (MI) | 55 | ? | |
| 1921 | L | Port Jervis HS (NY) | 0 | Middletown HS (NY) | 13 | ? | |
| 1921 | L | Port Jervis HS (NY) | 0 | New York Military Academy | 6 | ? | |
| 1921 | W | Port Jervis HS (NY) | 19 | Newton HS (NJ) | 0 | ? | |
| 1921 | W | Port Jervis HS (NY) | 13 | Poughkeepsie HS (NY) | 12 | ? | |
| 1921 | W | Port Washington HS (NY) | 21 | Friends Academy | 0 | ? | |
| 1921 | W | Port Washington HS (NY) | 7 | Friends Academy | 0 | ? | |
| 1921 | T | Port Washington HS (NY) | 0 | Glen Cove HS (NY) | 0 | ? | |
| 1921 | W | Port Washington HS (NY) | 19 | Lawrence HS (NY) | 3 | ? | |
| 1921 | W | Port Washington HS (NY) | 1 | Lynbrook HS (NY) | 0 | ? | |
| 1921 | W | Port Washington HS (NY) | 34 | Oyster Bay HS (NY) | 0 | ? | |
| 1921 | W | Portage HS (WI) | 2 | Watertown HS (WI) | 0 | ? | |
| 1921 | L | Portales HS (NM) | 0 | Roswell HS (NM) | 66 | ? | |
| 1921 | L | Portales HS (NM) | 0 | Roswell HS (NM) | 33 | ? | |
| 1921 | L | Porter Military Academy (SC) | 7 | Bailey Military Institute (SC) | 14 | ? | |
| 1921 | W | Porter Military Academy (SC) | 37 | Benedict (SC) | 0 | ? | |
| 1921 | W | Porter Military Academy (SC) | 37 | Benedictine College (GA) | 0 | ? | |
| 1921 | W | Porter Military Academy (SC) | 35 | Carlisle Fitting School (SC) | 7 | ? | |
| 1921 | W | Porter Military Academy (SC) | 14 | Chatham Academy | 0 | ? | |
| 1921 | W | Porter Military Academy (SC) | 28 | Florence HS (SC) | 0 | ? | |
| 1921 | W | Porter Military Academy (SC) | 14 | Richmond Academy (GA) | 6 | ? | |
| 1921 | W | Porter Military Academy (SC) | 33 | Wofford Fitting School (SC) | 0 | ? | |
| 1921 | W | Porterville HS (CA) | 21 | Dinuba HS (CA) | 0 | ? | |
| 1921 | L | Porterville HS (CA) | 7 | Kern County HS (CA) | 42 | ? | |
| 1921 | W | Portland Benson Polytechnic School (OR) | 58 | James John HS (OR) | 7 | ? | |
| 1921 | L | Portland Benson Polytechnic School (OR) | 0 | Portland Washington HS (OR) | 21 | ? | |
| 1921 | L | Portland Franklin HS (OR) | 7 | Portland Washington HS (OR) | 25 | ? | |
| 1921 | W | Portland HS (ME) | 7 | Bangor HS (ME) | 0 | ? | |
| 1921 | W | Portland HS (ME) | 14 | Bangor HS (ME) | 6 | ? | |
| 1921 | L | Portland HS (ME) | 6 | Deering HS | 7 | ? | |
| 1921 | W | Portland HS (ME) | 7 | Deering HS | 0 | ? | |
| 1921 | W | Portland HS (ME) | 7 | Lewiston HS (ME) | 0 | ? | |
| 1921 | L | Portland HS (ME) | 0 | Manchester HS (NH) | 13 | ? | |
| 1921 | T | Portland HS (ME) | 0 | Waltham HS (MA) | 0 | ? | |
| 1921 | W | Portland HS of Commerce (OR) | 7 | James John HS (OR) | 6 | ? | |
| 1921 | L | Portland HS of Commerce (OR) | 0 | Portland Washington HS (OR) | 13 | ? | |
| 1921 | L | Portland Jefferson HS (OR) | 0 | Portland Washington HS (OR) | 16 | ? | |
| 1921 | L | Portland Lincoln HS (OR) | 0 | Portland Washington HS (OR) | 42 | ? | |
| 1921 | L | Portland Washington HS (OR) | 7 | Everett HS (WA) | 48 | ? | |
| 1921 | W | Portland Washington HS (OR) | 56 | James John HS (OR) | 0 | ? | |
| 1921 | W | Portland Washington HS (OR) | 21 | Portland Benson Polytechnic School (OR) | 0 | ? | |
| 1921 | W | Portland Washington HS (OR) | 25 | Portland Franklin HS (OR) | 7 | ? | |
| 1921 | W | Portland Washington HS (OR) | 13 | Portland HS of Commerce (OR) | 0 | ? | |
| 1921 | W | Portland Washington HS (OR) | 16 | Portland Jefferson HS (OR) | 0 | ? | |
| 1921 | W | Portland Washington HS (OR) | 42 | Portland Lincoln HS (OR) | 0 | ? | |
| 1921 | L | Portsmouth HS (NH) | 0 | Haverhill Saint James HS (MA) | 49 | ? | |
| 1921 | W | Portsmouth HS (NH) | 6 | Phillips Exeter Academy (NH) | 0 | ? | |
| 1921 | L | Portsmouth HS (OH) | 0 | Chillicothe HS (OH) | 7 | ? | |
| 1921 | L | Portsmouth HS (OH) | 0 | Huntington HS (WV) | 28 | ? | |
| 1921 | L | Portsmouth HS (VA) | 0 | Newport News HS (VA) | 7 | ? | |
| 1921 | T | Potomac School | 0 | Bellefonte Academy (PA) | 0 | ? | |
| 1921 | W | Potomac St. (WV) | 12 | Broaddus College (WV) | 0 | ? | |
| 1921 | T | Potomac St. (WV) | 0 | Davis & Elkins (WV) | 0 | ? | |
| 1921 | T | Potomac St. (WV) | 0 | West Virginia Tech | 0 | ? | |
| 1921 | W | Potsdam HS (NY) | 7 | Massena HS (NY) | 0 | ? | |
| 1921 | L | Potsdam HS (NY) | 6 | Massena HS (NY) | 34 | ? | |
| 1921 | W | Potter School (CA) | 9 | Centerville HS (CA) | 8 | ? | |
| 1921 | W | Potter School (CA) | 19 | Galileo HS | 7 | ? | |
| 1921 | L | Potter School (CA) | 6 | Hayward HS (CA) | 33 | ? | |
| 1921 | L | Potter School (CA) | 7 | Hitchcock Military Academy (CA) | 35 | ? | |
| 1921 | T | Potter School (CA) | 0 | Piedmont HS (CA) | 0 | ? | |
| 1921 | W | Potter School (CA) | 33 | Sacred Heart College (CA) | 7 | ? | |
| 1921 | L | Potter School (CA) | 0 | San Francisco HS of Commerce (CA) | 19 | ? | |
| 1921 | W | Potter School (CA) | 12 | San Francisco Mission HS (CA) | 6 | ? | |
| 1921 | L | Potter School (CA) | 0 | Stanford B Team (CA) | 7 | ? | |
| 1921 | W | Potter School (CA) | 14 | Tamalpais HS (CA) | 0 | ? | |
| 1921 | W | Potter School (CA) | 35 | William Warren Military School (CA) | 7 | ? | |
| 1921 | L | Pottstown HS (PA) | 0 | Coatesville HS (PA) | 14 | ? | |
| 1921 | L | Pottstown HS (PA) | 6 | Minersville HS (PA) | 8 | ? | |
| 1921 | L | Pottstown HS (PA) | 0 | Norristown HS (PA) | 19 | ? | |
| 1921 | L | Pottsville HS (AR) | 0 | Russellville HS (AR) | 46 | ? | |
| 1921 | L | Pottsville HS (PA) | 0 | Lancaster HS (PA) | 34 | ? | |
| 1921 | T | Poughkeepsie HS (NY) | 0 | Kingston HS (NY) | 0 | ? | |
| 1921 | L | Poughkeepsie HS (NY) | 0 | Middletown HS (NY) | 20 | ? | |
| 1921 | W | Poughkeepsie HS (NY) | 48 | Newburg HS (NY) | 10 | ? | |
| 1921 | W | Poughkeepsie HS (NY) | 19 | Newburgh HS (NY) | 7 | ? | |
| 1921 | L | Poughkeepsie HS (NY) | 12 | Port Jervis HS (NY) | 13 | ? | |
| 1921 | W | Poughkeepsie HS (NY) | 13 | Saint Stephen's College JV (NY) | 0 | ? | |
| 1921 | W | Poughkeepsie HS (NY) | 6 | Stone School (NY) | 0 | ? | |
| 1921 | L | Powder Point School | 0 | Moses Brown School (RI) | 54 | ? | |
| 1921 | L | Powell University Training School (TX) | 0 | Terrill Prep School (TX) | 7 | ? | |
| 1921 | L | Prairie Grove HS (AR) | 3 | Rogers HS (AR) | 40 | ? | |
| 1921 | L | Prairie View A&M (TX) | 3 | Wiley (TX) | 7 | ? | |
| 1921 | L | Presbyterian (SC) | 0 | Citadel (SC) | 20 | Clinton, SC | |
| 1921 | L | Presbyterian (SC) | 0 | Davidson (NC) | 7 | Davidson, NC | |
| 1921 | L | Presbyterian (SC) | 7 | Erskine (SC) | 21 | Clinton, SC | |
| 1921 | L | Presbyterian (SC) | 7 | Newberry (SC) | 15 | Newberry, SC | |
| 1921 | L | Presbyterian (SC) | 0 | South Carolina | 48 | Columbia, SC | |
| 1921 | L | Presbyterian (SC) | 0 | Fort Benning (GA) | 27 | Columbus, GA | |
| 1921 | L | Presbyterian (SC) | 0 | Clemson (SC) | 34 | Clemson, SC | |
| 1921 | W | Presbyterian (SC) | 27 | Wofford (SC) | 0 | Clinton, SC | |
| 1921 | W | Prescott HS (AZ) | 27 | Northern Arizona | 6 | Prescott, AZ | |
| 1921 | L | Presidio of San Francisco (CA) | 0 | William Warren Military School (CA) | 60 | ? | |
| 1921 | L | Preston HS (MN) | 0 | Lanesboro HS (MN) | 41 | ? | |
| 1921 | L | Preston Industrial School (CA) | 7 | California-Davis | 13 | ? | |
| 1921 | W | Preston Industrial School (CA) | 14 | Sacramento HS (CA) | 12 | ? | |
| 1921 | L | Princeton (NJ) | 0 | Chicago (IL) | 9 | Princeton, NJ | |
| 1921 | L | Princeton (NJ) | 0 | Navy (MD) | 13 | Annapolis, MD | |
| 1921 | W | Princeton (NJ) | 34 | Virginia | 0 | Princeton, NJ | |
| 1921 | W | Princeton (NJ) | 21 | Swarthmore (PA) | 7 | Princeton, NJ | |
| 1921 | W | Princeton (NJ) | 10 | Harvard (MA) | 3 | Princeton, NJ | |
| 1921 | W | Princeton (NJ) | 19 | Colgate (NY) | 0 | Princeton, NJ | |
| 1921 | L | Princeton (NJ) | 7 | Yale (CT) | 13 | New Haven, CT | |
| 1921 | L | Princeton Freshmen (NJ) | 0 | Kiski Academy (PA) | 35 | ? | |
| 1921 | L | Princeton Freshmen (NJ) | 0 | Mercersburg Academy (PA) | 7 | ? | |
| 1921 | W | Princeton Freshmen (NJ) | 33 | Peddie Institute (NJ) | 0 | ? | |
| 1921 | L | Princeton HS (IL) | 7 | LaSalle-Peru HS (IL) | 20 | ? | |
| 1921 | L | Princeton HS (MN) | 0 | Anoka HS (MN) | 54 | ? | |
| 1921 | L | Princeton HS (MN) | 0 | Milaca HS (MN) | 52 | ? | |
| 1921 | T | Princeton HS (NJ) | 0 | Bordentown Manual Training (NJ) | 0 | ? | |
| 1921 | W | Princeton HS (NJ) | 35 | Flemington HS (NJ) | 0 | ? | |
| 1921 | W | Princeton HS (NJ) | 7 | Freehold HS (NJ) | 0 | ? | |
| 1921 | L | Princeton HS (NJ) | 0 | Lakewood HS (NJ) | 7 | ? | |
| 1921 | W | Princeton HS (NJ) | 6 | Lambertville HS (NJ) | 0 | ? | |
| 1921 | L | Princeton HS (NJ) | 7 | New Brunswick HS (NJ) | 13 | ? | |
| 1921 | L | Princeton HS (NJ) | 0 | New Jersey (NJ) | 27 | ? | |
| 1921 | T | Princeton HS (NJ) | 6 | Palmyra HS (NJ) | 6 | ? | |
| 1921 | T | Princeton HS (NJ) | 0 | Princeton HS Alumni (NJ) | 0 | ? | |
| 1921 | W | Princeton HS (NJ) | 33 | Toms River HS (NJ) | 0 | ? | |
| 1921 | T | Princeton HS Alumni (NJ) | 0 | Princeton HS (NJ) | 0 | ? | |
| 1921 | W | Princeton Prep School (NJ) | 32 | Bordentown Military Institute (NJ) | 0 | Bordentown, NJ | |
| 1921 | L | Princeton Prep School (NJ) | 0 | Hill School (PA) | 14 | ? | |
| 1921 | L | Princeton Prep School (NJ) | 0 | Lawrenceville School (NJ) | 14 | ? | |
| 1921 | W | Princeton Prep School (NJ) | 12 | New Rochelle HS (NY) | 7 | ? | |
| 1921 | W | Princeton Prep School (NJ) | 47 | Newman School (NJ) | 0 | ? | |
| 1921 | W | Princeton Prep School (NJ) | 13 | Rutgers Prep School (NJ) | 0 | ? | |
| 1921 | T | Principia Academy (MO) | 0 | Central Wesleyan (MO) | 0 | Saint Louis, MO | |
| 1921 | W | Principia Academy (MO) | 56 | Granite City HS (IL) | 0 | ? | |
| 1921 | W | Principia Academy (MO) | 10 | Maplewood HS (MO) | 0 | ? | |
| 1921 | T | Principia Academy (MO) | 7 | Saint Louis Central HS (MO) | 7 | ? | |
| 1921 | W | Principia Academy (MO) | 35 | Saint Louis McKinley HS (MO) | 0 | ? | |
| 1921 | W | Principia Academy (MO) | 27 | Saint Louis Yeatman HS (MO) | 0 | ? | |
| 1921 | L | Principia Academy (MO) | 0 | Washington Freshmen (MO) | 28 | ? | |
| 1921 | L | Providence (RI) | 7 | Holy Cross B Team (MA) | 19 | Providence, RI | Hope High School |
| 1921 | L | Providence (RI) | 12 | La Salle Academy | 17 | Providence, RI | Hope High School |
| 1921 | L | Providence (RI) | 0 | MIT (MA) | 6 | Cambridge, MA | |
| 1921 | W | Providence (RI) | 87 | RISD | 0 | Providence, RI | Hope High School |
| 1921 | W | Providence (RI) | 28 | East Greenwich Academy (RI) | 0 | East Greenwich, RI | |
| 1921 | L | Providence (RI) | 0 | Boston College (MA) | 25 | Chestnut Hill, MA | |
| 1921 | L | Providence Tech HS (RI) | 7 | Moses Brown School (RI) | 15 | ? | |
| 1921 | L | Providence Tech HS (RI) | 0 | Natick HS (MA) | 6 | ? | |
| 1921 | L | Providence Tech HS (RI) | 0 | Waltham HS (MA) | 34 | ? | |
| 1921 | W | Proviso Township HS (IL) | 14 | Chicago Austin HS (IL) | 6 | ? | |
| 1921 | L | Proviso Township HS (IL) | 0 | Deerfield Shields HS (IL) | 27 | ? | |
| 1921 | W | Proviso Township HS (IL) | 13 | Fitchburg HS (MA) | 6 | ? | |
| 1921 | W | Proviso Township HS (IL) | 20 | Kankakee HS (IL) | 0 | ? | |
| 1921 | W | Proviso Township HS (IL) | 6 | La Grange HS (IL) | 0 | ? | |
| 1921 | W | Proviso Township HS (IL) | 57 | Morton HS (IL) | 0 | ? | |
| 1921 | W | Proviso Township HS (IL) | 27 | New Trier HS | 0 | ? | |
| 1921 | T | Proviso Township HS (IL) | 7 | Oak Park HS (IL) | 7 | ? | |
| 1921 | W | Proviso Township HS (IL) | 27 | Riverside HS (IL) | 13 | ? | |
| 1921 | W | Proviso Township HS (IL) | 33 | Thornton HS (IL) | 0 | ? | |
| 1921 | L | Pryor HS (OK) | 7 | Sapulpa HS (OK) | 33 | ? | |
| 1921 | L | Pueblo Centennial HS (CO) | 0 | Colorado Springs HS (CO) | 31 | ? | |
| 1921 | L | Pueblo Centennial HS (CO) | 6 | Colorado Springs HS (CO) | 18 | ? | |
| 1921 | W | Pueblo Centennial HS (CO) | 21 | Florence HS (CO) | 7 | ? | |
| 1921 | W | Pueblo Centennial HS (CO) | 21 | Florence HS (CO) | 13 | ? | |
| 1921 | W | Pueblo Centennial HS (CO) | 7 | La Junta HS (CO) | 0 | ? | |
| 1921 | W | Pueblo Centennial HS (CO) | 27 | Ordway HS (CO) | 0 | ? | |
| 1921 | L | Pueblo Centennial HS (CO) | 0 | Pueblo Central HS (CO) | 13 | ? | |
| 1921 | L | Pueblo Centennial HS (CO) | 14 | Trinidad HS (CO) | 16 | ? | |
| 1921 | L | Puget Sound (WA) | 10 | 9th Army Corps (WA) | 28 | Tacoma, WA | |
| 1921 | L | Puget Sound (WA) | 6 | Western Washington | 17 | Bellingham, WA | |
| 1921 | W | Puget Sound (WA) | 18 | Willamette (OR) | 7 | Tacoma, WA | |
| 1921 | W | Puget Sound (WA) | 6 | Central Washington | 0 | Ellensburg, WA | |
| 1921 | W | Puget Sound (WA) | 26 | Bremerton Navy (WA) | 0 | Tacoma, WA | |
| 1921 | L | Puget Sound (WA) | 14 | Pacific (OR) | 21 | Tacoma, WA | |
| 1921 | L | Puget Sound Freshmen (WA) | 14 | Chehalis HS (WA) | 39 | ? | |
| 1921 | L | Pullman HS (WV) | 0 | West Union HS (WV) | 34 | ? | |
| 1921 | L | Pullman Tech (IL) | 0 | Chicago Bowen HS (IL) | 12 | ? | |
| 1921 | L | Punchard HS (MA) | 0 | Danvers HS (MA) | 12 | ? | |
| 1921 | W | Punchard HS (MA) | 34 | Howe HS | 0 | ? | |
| 1921 | T | Punchard HS (MA) | 7 | Johnson HS | 7 | ? | |
| 1921 | L | Punchard HS (MA) | 6 | Lawrence HS (MA) | 40 | ? | |
| 1921 | W | Punchard HS (MA) | 7 | Methuen HS (MA) | 0 | ? | |
| 1921 | W | Punchard HS (MA) | 12 | Methuen HS (MA) | 7 | ? | |
| 1921 | W | Punchard HS (MA) | 7 | Phillips Exeter Academy (NH) | 0 | ? | |
| 1921 | T | Punchard HS (MA) | 7 | Pinkerton Academy | 7 | ? | |
| 1921 | W | Punchard HS (MA) | 13 | Ward Hill HS (MA) | 0 | ? | |
| 1921 | L | Purdue (IN) | 0 | Indiana | 3 | Bloomington, IN | |
| 1921 | L | Purdue (IN) | 6 | Iowa | 13 | West Lafayette, IN | |
| 1921 | L | Purdue (IN) | 0 | Notre Dame (IN) | 33 | West Lafayette, IN | |
| 1921 | L | Purdue (IN) | 0 | Wabash (IN) | 9 | West Lafayette, IN | |
| 1921 | W | Purdue (IN) | 3 | Northwestern (IL) | 0 | West Lafayette, IN | |
| 1921 | L | Purdue (IN) | 0 | Chicago (IL) | 9 | Chicago, IL | |
| 1921 | L | Purdue (IN) | 0 | Ohio St. | 28 | Columbus, OH | |
| 1921 | L | Pyramid AA (IL) | 0 | Benedictine (IL) | 40 | Lisle, IL | |
| 1921 | W | Quakertown HS (PA) | 37 | Ambler HS (PA) | 0 | ? | |
| 1921 | W | Quakertown HS (PA) | 68 | Bristol HS (PA) | 0 | ? | |
| 1921 | L | Quakertown HS (PA) | 0 | Delaware Valley (PA) | 7 | ? | |
| 1921 | W | Quakertown HS (PA) | 24 | Lansdale HS (PA) | 7 | ? | |
| 1921 | W | Quakertown HS (PA) | 98 | Nazareth Hall Military Academy (PA) | 0 | ? | |
| 1921 | T | Quakertown HS (PA) | 7 | Perkasie HS (PA) | 7 | ? | |
| 1921 | W | Quakertown HS (PA) | 19 | Perkiomen Seminary JV (PA) | 7 | ? | |
| 1921 | W | Quakertown HS (PA) | 21 | Sellersville HS (PA) | 0 | ? | |
| 1921 | L | Quakertown HS (PA) | 6 | Upper Darby HS (PA) | 7 | ? | |
| 1921 | W | Quakertown HS (PA) | 7 | Wilson HS (PA) | 6 | ? | |
| 1921 | L | Quincy (IL) | 0 | Culver-Stockton (MO) | 26 | Quincy, IL | |
| 1921 | L | Quincy (IL) | 6 | Quincy All-Stars (IL) | 20 | ? | |
| 1921 | L | Quincy (IL) | 0 | Saint Ambrose (IA) | 46 | Davenport, IA | |
| 1921 | L | Quincy (IL) | 7 | Western Illinois | 14 | Macomb, IL | |
| 1921 | L | Quincy (IL) | 0 | Carthage (WI) | 48 | Quincy, IL | |
| 1921 | L | Quincy (IL) | 6 | Hedding (IL) | 7 | Quincy, IL | |
| 1921 | W | Quincy All-Stars (IL) | 20 | Quincy (IL) | 6 | ? | |
| 1921 | W | Quincy HS (IL) | 56 | Barry HS (IL) | 0 | ? | |
| 1921 | W | Quincy HS (IL) | 21 | Camp Point HS (IL) | 0 | ? | |
| 1921 | W | Quincy HS (IL) | 23 | Carthage HS (IL) | 7 | ? | |
| 1921 | L | Quincy HS (IL) | 0 | Galesburg HS (IL) | 21 | ? | |
| 1921 | T | Quincy HS (IL) | 7 | Hannibal HS (MO) | 7 | ? | |
| 1921 | L | Quincy HS (IL) | 6 | Jacksonville HS (IL) | 13 | ? | |
| 1921 | L | Quincy HS (IL) | 0 | Keokuk HS (IA) | 2 | ? | |
| 1921 | L | Quincy HS (IL) | 7 | Macomb HS (IL) | 13 | ? | |
| 1921 | T | Quincy HS (IL) | 0 | Monmouth HS (IL) | 0 | ? | |
| 1921 | L | Quincy HS (IL) | 0 | Pittsfield HS (IL) | 36 | ? | |
| 1921 | W | Quincy HS (IL) | 41 | Shelbina HS (MO) | 14 | ? | |
| 1921 | L | Quincy HS (MA) | 0 | Boston Latin School (MA) | 7 | ? | |
| 1921 | W | Quincy HS (MA) | 43 | Braintree HS (MA) | 0 | ? | |
| 1921 | L | Quincy HS (MA) | 0 | Brockton HS (MA) | 34 | ? | |
| 1921 | L | Quincy HS (MA) | 0 | Marblehead HS (MA) | 20 | ? | |
| 1921 | W | Quincy HS (MA) | 20 | Milton HS (MA) | 0 | ? | |
| 1921 | W | Quincy HS (MA) | 7 | Natick HS (MA) | 6 | ? | |
| 1921 | L | Quincy HS (MA) | 0 | Newton North HS (MA) | 7 | ? | |
| 1921 | W | Quincy HS (MA) | 7 | Quincy HS Alumni (MA) | 0 | ? | |
| 1921 | W | Quincy HS (MA) | 29 | Rockland HS (MA) | 0 | ? | |
| 1921 | W | Quincy HS (MA) | 27 | Thayer Academy (MA) | 7 | ? | |
| 1921 | L | Quincy HS (MA) | 0 | Waltham HS (MA) | 14 | ? | |
| 1921 | L | Quincy HS Alumni (MA) | 0 | Quincy HS (MA) | 7 | ? | |
| 1921 | L | R. Ascham | 0 | Bronxville HS (NY) | 1 | ? | |
| 1921 | L | Radnor HS (PA) | 0 | Bryn Athyn HS (PA) | 7 | ? | |
| 1921 | W | Radnor HS (PA) | 39 | Cheltenham HS (PA) | 0 | ? | |
| 1921 | L | Radnor HS (PA) | 0 | Lansdowne HS (PA) | 7 | ? | |
| 1921 | W | Radnor HS (PA) | 21 | Lower Merion HS (PA) | 7 | ? | |
| 1921 | W | Radnor HS (PA) | 7 | Penn Charter School (PA) | 0 | ? | |
| 1921 | W | Radnor HS (PA) | 21 | Philadelphia Catholic HS (PA) | 0 | ? | |
| 1921 | W | Radnor HS (PA) | 6 | Philadelphia West HS (PA) | 0 | ? | |
| 1921 | W | Radnor HS (PA) | 20 | Tredyffun-Easttown HS (PA) | 0 | ? | |
| 1921 | L | Raeford HS (NC) | 0 | Chapel Hill HS (NC) | 6 | ? | |
| 1921 | L | Rahway HS (NJ) | 0 | Chatham HS (NJ) | 12 | ? | |
| 1921 | L | Rahway HS (NJ) | 0 | Nutley HS (NJ) | 31 | ? | |
| 1921 | W | Rahway HS (NJ) | 33 | Roselle HS (NJ) | 0 | ? | |
| 1921 | W | Rahway HS (NJ) | 13 | Roselle Park HS (NJ) | 0 | ? | |
| 1921 | W | Rahway HS (NJ) | 6 | Summit HS (NJ) | 0 | ? | |
| 1921 | W | Rahway HS (NJ) | 30 | Westfield HS (NJ) | 0 | ? | |
| 1921 | L | Raleigh HS (NC) | 0 | Durham HS (NC) | 20 | ? | |
| 1921 | L | Raleigh HS (NC) | 0 | Durham HS (NC) | 41 | ? | |
| 1921 | L | Raleigh HS (NC) | 0 | Rocky Mount HS (NC) | 42 | ? | |
| 1921 | L | Raleigh HS (NC) | 0 | Smithfield HS (NC) | 7 | ? | |
| 1921 | L | Raleigh Smith County HS (MS) | 0 | Southern Mississippi | 113 | Hattiesburg, MS | |
| 1921 | W | Ramer HS (AL) | 13 | Troy (AL) | 7 | Troy, AL | |
| 1921 | W | Ramer HS (AL) | 65 | Troy (AL) | 0 | Ramer, AL | |
| 1921 | W | Ramona HS (OK) | 54 | Collinsville HS (OK) | 0 | ? | |
| 1921 | L | Ramona HS (OK) | 6 | Tulsa Central HS (OK) | 14 | ? | |
| 1921 | L | Ramsey HS (NJ) | 0 | Hackensack HS (NJ) | 33 | ? | |
| 1921 | T | Ramsey HS (NJ) | 6 | Leonia HS (NJ) | 6 | ? | |
| 1921 | W | Ramsey HS (NJ) | 13 | MacKenzie School (NY) | 0 | ? | |
| 1921 | L | Ramsey HS (NJ) | 0 | Middletown HS (NY) | 46 | ? | |
| 1921 | L | Ramsey HS (NJ) | 3 | Park Ridge HS (NJ) | 26 | ? | |
| 1921 | L | Ramsey HS (NJ) | 3 | Park Ridge HS (NJ) | 6 | ? | |
| 1921 | T | Ramsey HS (NJ) | 6 | Spring Valley HS (NY) | 6 | ? | |
| 1921 | W | Ramsey HS (NJ) | 31 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | L | Randolph-Macon (VA) | 0 | Duke (NC) | 6 | Durham, NC | |
| 1921 | L | Randolph-Macon (VA) | 0 | North Carolina St. | 21 | Raleigh, NC | |
| 1921 | L | Randolph-Macon (VA) | 0 | William & Mary (VA) | 35 | Williamsburg, VA | |
| 1921 | L | Randolph-Macon (VA) | 0 | Washington & Lee (VA) | 41 | Lexington, VA | |
| 1921 | L | Randolph-Macon (VA) | 0 | Hampden-Sydney (VA) | 21 | Richmond, VA | |
| 1921 | L | Randolph-Macon (VA) | 0 | Richmond (VA) | 49 | Richmond, VA | |
| 1921 | L | Randolph-Macon Academy (VA) | 0 | Alexandria Episcopal HS (VA) | 47 | ? | |
| 1921 | L | Randolph-Macon Academy (VA) | 8 | Chatham Training School (VA) | 39 | ? | |
| 1921 | L | Randolph-Macon Academy (VA) | 0 | Fork Union Military Academy (VA) | 68 | ? | |
| 1921 | L | Randolph-Macon Academy (VA) | 0 | Roanoke (VA) | 41 | ? | |
| 1921 | W | Randolph-Macon Academy (VA) | 13 | Salem HS (VA) | 7 | ? | |
| 1921 | L | Randolph-Macon Academy (VA) | 0 | Shenandoah Military Academy (VA) | 26 | ? | |
| 1921 | L | Randolph-Macon Academy (VA) | 0 | Shenandoah Military Academy (VA) | 28 | ? | |
| 1921 | W | Randolph-Macon Academy (VA) | 78 | Shepherd (WV) | 0 | Shepherdstown, WV | |
| 1921 | L | Randolph-Macon Academy (VA) | 7 | Virginia Episcopal School (VA) | 13 | ? | |
| 1921 | L | Ranier HS | 0 | Astoria HS (OR) | 7 | ? | |
| 1921 | L | Rankea Trade | 7 | Chaminade College HS (MO) | 28 | ? | |
| 1921 | L | Raton HS (NM) | 7 | Clayton HS (NM) | 34 | ? | |
| 1921 | L | Raton HS (NM) | 0 | Clayton HS (NM) | 6 | ? | |
| 1921 | L | Raton HS (NM) | 3 | Trinidad HS (CO) | 27 | ? | |
| 1921 | T | Rawson HS (OH) | 0 | Mount Blanchard HS (OH) | 0 | ? | |
| 1921 | L | Reading HS (PA) | 6 | Allentown HS (PA) | 34 | ? | |
| 1921 | L | Reading HS (PA) | 0 | Easton HS (PA) | 35 | ? | |
| 1921 | L | Reading HS (PA) | 7 | Norristown HS (PA) | 25 | ? | |
| 1921 | W | Reading HS (PA) | 14 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | L | Receiving Ship (NY) | 0 | New London Submarine Base (CT) | 112 | ? | |
| 1921 | W | Receiving Ship (NY) | 3 | SUNY-Farmingdale (NY) | 2 | ? | |
| 1921 | W | Red Bank HS (NJ) | 24 | Atlantic Highlands HS (NJ) | 6 | ? | |
| 1921 | L | Red Bank HS (NJ) | 0 | Freehold HS (NJ) | 28 | ? | |
| 1921 | L | Red Bank HS (NJ) | 0 | Jersey City Dickinson HS (NJ) | 28 | ? | |
| 1921 | T | Red Bank HS (NJ) | 0 | Leonardo HS (NJ) | 0 | ? | |
| 1921 | W | Red Bank HS (NJ) | 6 | Leonardo HS (NJ) | 0 | ? | |
| 1921 | L | Red Bank HS (NJ) | 0 | Newman School (NJ) | 13 | ? | |
| 1921 | L | Red Bank HS (NJ) | 0 | Point Pleasant HS (NJ) | 21 | ? | |
| 1921 | L | Red Bank HS (NJ) | 0 | South Orange Columbia HS (NJ) | 53 | ? | |
| 1921 | W | Red Bank HS (NJ) | 24 | Toms River HS (NJ) | 0 | ? | |
| 1921 | L | Red Lake Falls HS (MN) | 13 | Thief River Falls HS (MN) | 31 | ? | |
| 1921 | T | Red Oak HS (NC) | 13 | Rocky Mount HS (NC) | 13 | ? | |
| 1921 | W | Red Oak HS (NC) | 32 | Rocky Mount HS (NC) | 0 | ? | |
| 1921 | W | Red Wing HS (MN) | 66 | Lake City HS (MN) | 0 | ? | |
| 1921 | W | Red Wing HS (MN) | 42 | River Falls HS (WI) | 0 | ? | |
| 1921 | L | Red Wing HS (MN) | 7 | Rochester HS (MN) | 17 | ? | |
| 1921 | W | Red Wing HS (MN) | 51 | Wabasha HS (MN) | 3 | ? | |
| 1921 | W | Red Wing HS (MN) | 13 | Winona HS (MN) | 3 | ? | |
| 1921 | L | Redfield HS (SD) | 12 | Clark HS (SD) | 35 | ? | |
| 1921 | L | Redfield HS (SD) | 0 | Clark HS (SD) | 7 | ? | |
| 1921 | W | Redlands (CA) | 30 | California Tech | 6 | Pasadena, CA | |
| 1921 | W | Redlands (CA) | 24 | Occidental (CA) | 7 | Los Angeles, CA | |
| 1921 | W | Redlands (CA) | 63 | San Bernardino HS (CA) | 0 | ? | |
| 1921 | W | Redlands (CA) | 47 | Santa Fe Shops | 7 | ? | |
| 1921 | T | Redlands (CA) | 0 | Sherman Indian School (CA) | 0 | ? | |
| 1921 | L | Redlands (CA) | 2 | Submarine Base | 6 | ? | |
| 1921 | L | Redlands (CA) | 7 | Whittier (CA) | 16 | Redlands, CA | |
| 1921 | W | Redlands (CA) | 17 | Pomona-Pitzer (CA) | 7 | Redlands, CA | |
| 1921 | W | Redlands (CA) | 35 | UCLA | 7 | Los Angeles, CA | |
| 1921 | T | Redlands HS (CA) | 0 | Chaffee HS (CA) | 0 | ? | |
| 1921 | L | Reedley College (CA) | 7 | Selma HS (CA) | 21 | ? | |
| 1921 | L | Reedley HS (CA) | 7 | Fresno HS (CA) | 19 | ? | |
| 1921 | L | Regis (CO) | 0 | Colorado College Freshmen | 7 | ? | |
| 1921 | W | Regis (CO) | 14 | Colorado Freshmen | 0 | ? | |
| 1921 | W | Regis (CO) | 27 | Colorado School of Mines Freshmen | 7 | ? | |
| 1921 | L | Regis (CO) | 7 | Colorado St. Freshmen | 21 | ? | |
| 1921 | W | Regis (CO) | 21 | Denver East HS (CO) | 0 | ? | |
| 1921 | L | Regis (CO) | 0 | Denver Freshmen (CO) | 7 | ? | |
| 1921 | W | Regis (CO) | 3 | Denver Freshmen (CO) | 0 | ? | |
| 1921 | W | Regis (CO) | 21 | Denver Manual HS (CO) | 0 | ? | |
| 1921 | W | Regis (CO) | 21 | Denver West HS (CO) | 0 | ? | |
| 1921 | T | Regis (CO) | 0 | K. of C. | 0 | ? | |
| 1921 | T | Reno HS (NV) | 7 | Bishop HS (CA) | 7 | ? | |
| 1921 | W | Rensselaer Independents (IN) | 20 | Saint Joseph's (IN) | 0 | ? | |
| 1921 | T | Rensselaer Tech (NY) | 0 | Buffalo (NY) | 0 | Buffalo, NY | |
| 1921 | W | Rensselaer Tech (NY) | 49 | Hamilton (NY) | 0 | Troy, NY | |
| 1921 | L | Rensselaer Tech (NY) | 3 | Rochester (NY) | 6 | Rochester, NY | |
| 1921 | W | Rensselaer Tech (NY) | 23 | Stevens Tech (NJ) | 0 | Troy, NY | |
| 1921 | T | Rensselaer Tech (NY) | 6 | Saint Lawrence (NY) | 6 | Troy, NY | |
| 1921 | W | Rensselaer Tech (NY) | 21 | Hobart (NY) | 0 | Troy, NY | |
| 1921 | T | Rensselaer Tech (NY) | 0 | Norwich (VT) | 0 | Northfield, VT | |
| 1921 | W | Rensselaer Tech (NY) | 7 | Worcester Tech (MA) | 6 | Worcester, MA | |
| 1921 | L | Repton HS (AL) | 0 | Jackson Agricultural School (AL) | 26 | ? | |
| 1921 | L | Repton HS (AL) | 6 | Troy (AL) | 12 | Troy, AL | |
| 1921 | W | Reserve Destroyers (CA) | 3 | San Diego St. (CA) | 0 | San Diego, CA | College Field |
| 1921 | L | Revere HS (MA) | 0 | Beverly HS (MA) | 7 | ? | |
| 1921 | W | Revere HS (MA) | 33 | Chelsea HS (MA) | 0 | ? | |
| 1921 | L | Revere HS (MA) | 0 | Gloucester HS (MA) | 7 | ? | |
| 1921 | L | Revere HS (MA) | 0 | Lynn Classical HS (MA) | 7 | ? | |
| 1921 | W | Revere HS (MA) | 6 | Lynn English HS (MA) | 0 | ? | |
| 1921 | W | Revere HS (MA) | 14 | Marblehead HS (MA) | 0 | ? | |
| 1921 | L | Revere HS (MA) | 0 | Peabody HS (MA) | 21 | ? | |
| 1921 | L | Revere HS (MA) | 0 | Swampscott HS (MA) | 6 | ? | |
| 1921 | W | Revere HS (MA) | 13 | Winthrop HS (MA) | 0 | ? | |
| 1921 | L | Rhode Island | 0 | Boston (MA) | 14 | Boston, MA | |
| 1921 | L | Rhode Island | 0 | Brown (RI) | 6 | Providence, RI | |
| 1921 | W | Rhode Island | 27 | Connecticut | 21 | Kingston, RI | |
| 1921 | L | Rhode Island | 3 | Maine | 7 | Orono, ME | |
| 1921 | L | Rhode Island | 0 | New London Submarine Base (CT) | 13 | New London, CT | |
| 1921 | W | Rhode Island | 27 | Worcester Tech (MA) | 0 | Worcester, MA | |
| 1921 | L | Rhode Island | 0 | Bowdoin (ME) | 9 | Brunswick, ME | |
| 1921 | W | Rhode Island | 7 | Massachusetts | 2 | Kingston, RI | |
| 1921 | L | Rhodes (TN) | 0 | Bryson (TN) | 7 | ? | |
| 1921 | W | Rhodes (TN) | 13 | Cumberland (TN) | 0 | ? | |
| 1921 | L | Rhodes (TN) | 0 | Mississippi | 35 | Oxford, MS | |
| 1921 | W | Rhodes (TN) | 30 | Ogden College (KY) | 0 | ? | |
| 1921 | W | Rhodes (TN) | 21 | Ogden College (KY) | 14 | ? | |
| 1921 | L | Rhodes (TN) | 0 | Union (TN) | 27 | Jackson, TN | |
| 1921 | L | Rhodes (TN) | 0 | Western Kentucky | 12 | ? | |
| 1921 | L | Rhodes (TN) | 6 | Birmingham-Southern (AL) | 38 | Birmingham, AL | |
| 1921 | L | Rice (TX) | 0 | Oklahoma | 27 | Houston, TX | |
| 1921 | W | Rice (TX) | 27 | Southwestern (TX) | 0 | Houston, TX | |
| 1921 | L | Rice (TX) | 0 | Texas | 56 | Austin, TX | |
| 1921 | W | Rice (TX) | 28 | Trinity (TX) | 14 | San Antonio, TX | |
| 1921 | L | Rice (TX) | 6 | Tulane (LA) | 7 | Houston, TX | |
| 1921 | W | Rice (TX) | 54 | Louisiana-Lafayette | 0 | Houston, TX | |
| 1921 | W | Rice (TX) | 7 | Southern Methodist (TX) | 0 | Houston, TX | |
| 1921 | L | Rice (TX) | 14 | Baylor (TX) | 17 | Waco, TX | |
| 1921 | T | Rice (TX) | 7 | Texas A&M | 7 | Houston, TX | |
| 1921 | W | Rice Freshmen (TX) | 28 | Terrill Prep School (TX) | 0 | ? | |
| 1921 | W | Richland District HS (WV) | 13 | Bridgeport HS (WV) | 0 | ? | |
| 1921 | W | Richland District HS (WV) | 6 | Follansbee HS (WV) | 0 | ? | |
| 1921 | L | Richland District HS (WV) | 0 | Linsly Military Institute (WV) | 27 | ? | |
| 1921 | L | Richland District HS (WV) | 0 | Moundsville HS (WV) | 24 | ? | |
| 1921 | L | Richland District HS (WV) | 0 | New Martinsville HS (WV) | 30 | ? | |
| 1921 | T | Richland District HS (WV) | 0 | Shadyside HS (OH) | 0 | ? | |
| 1921 | W | Richland District HS (WV) | 28 | Smithfield HS (WV) | 0 | ? | |
| 1921 | T | Richland District HS (WV) | 6 | Toronto HS (OH) | 6 | ? | |
| 1921 | L | Richland District HS (WV) | 9 | Toronto HS (OH) | 19 | ? | |
| 1921 | T | Richland District HS (WV) | 0 | Triadelphia HS (WV) | 0 | ? | |
| 1921 | L | Richland District HS (WV) | 0 | Wheeling HS (WV) | 20 | ? | |
| 1921 | T | Richmond (VA) | 14 | Davidson (NC) | 14 | Richmond, VA | |
| 1921 | L | Richmond (VA) | 5 | Hampden-Sydney (VA) | 7 | Richmond, VA | |
| 1921 | L | Richmond (VA) | 0 | Virginia Tech | 34 | Richmond, VA | |
| 1921 | W | Richmond (VA) | 17 | William & Mary (VA) | 7 | Richmond, VA | |
| 1921 | W | Richmond (VA) | 14 | Catholic (DC) | 0 | Richmond, VA | |
| 1921 | W | Richmond (VA) | 41 | Wake Forest (NC) | 0 | Richmond, VA | |
| 1921 | L | Richmond (VA) | 0 | Virginia | 14 | Charlottesville, VA | |
| 1921 | W | Richmond (VA) | 49 | Randolph-Macon (VA) | 0 | Richmond, VA | |
| 1921 | L | Richmond Academy (GA) | 6 | Porter Military Academy (SC) | 14 | ? | |
| 1921 | L | Richmond Blues (VA) | 0 | Fork Union Military Academy (VA) | 26 | ? | |
| 1921 | L | Richmond County Academy | 7 | Athens HS (GA) | 13 | ? | |
| 1921 | W | Richmond HS (CA) | 45 | Mount Diablo HS (CA) | 0 | ? | |
| 1921 | W | Richmond HS (CA) | 12 | San Francisco University School (CA) | 0 | ? | |
| 1921 | W | Richmond HS (CA) | 14 | Santa Rosa HS (CA) | 13 | ? | |
| 1921 | L | Richmond HS (OH) | 0 | Ashley HS (OH) | 49 | ? | |
| 1921 | L | Richmond HS (OH) | 6 | Marysville HS (OH) | 28 | ? | |
| 1921 | W | Richmond HS (OH) | 20 | Marysville HS (OH) | 18 | ? | |
| 1921 | W | Richmond HS (OH) | 18 | Mount Gilead HS (OH) | 7 | ? | |
| 1921 | L | Richmond HS (OH) | 6 | North Lewisburg HS (OH) | 32 | ? | |
| 1921 | W | Richmond HS (OH) | 6 | Richmond HS Alumni (OH) | 0 | ? | |
| 1921 | L | Richmond HS (OH) | 0 | Saint Mary's HS | 18 | ? | |
| 1921 | L | Richmond HS (OH) | 6 | Woodstock HS (OH) | 18 | ? | |
| 1921 | L | Richmond HS (VA) | 6 | Newport News HS (VA) | 20 | ? | |
| 1921 | L | Richmond HS Alumni (OH) | 0 | Richmond HS (OH) | 6 | ? | |
| 1921 | L | Richmond JV (VA) | 0 | Fork Union Military Academy (VA) | 48 | ? | |
| 1921 | L | Richmond Oceana HS (VA) | 0 | Newport News HS (VA) | 49 | ? | |
| 1921 | T | Ricks JC (ID) | 0 | Brigham Young College (UT) | 0 | ? | |
| 1921 | L | Ricks JC (ID) | 13 | Idaho St. | 37 | Pocatello, ID | |
| 1921 | T | Rider (NJ) | 0 | Burlington HS (NJ) | 0 | ? | |
| 1921 | L | Rider (NJ) | 0 | New Jersey (NJ) | 17 | Ewing, NJ | |
| 1921 | L | Rider (NJ) | 0 | Bordentown Manual Training (NJ) | 14 | Bordentown, NJ | |
| 1921 | L | Rider-Moore Business College (NJ) | 0 | Pennington Seminary (NJ) | 27 | ? | |
| 1921 | T | Ridgefield HS (WA) | 6 | James John HS (OR) | 6 | ? | |
| 1921 | W | Ridgefield Park HS (NJ) | 34 | Englewood HS (NJ) | 0 | ? | |
| 1921 | W | Ridgefield Park HS (NJ) | 20 | Union Hill HS (NJ) | 0 | ? | |
| 1921 | W | Ridgeway HS (PA) | 69 | Curwensville HS (PA) | 0 | ? | |
| 1921 | L | Ridgewood HS (NJ) | 7 | Cliffside Park HS (NJ) | 12 | ? | |
| 1921 | L | Ridgewood HS (NJ) | 13 | Dover HS (NJ) | 14 | ? | |
| 1921 | L | Ridgewood HS (NJ) | 0 | Englewood HS (NJ) | 3 | ? | |
| 1921 | W | Ridgewood HS (NJ) | 3 | Hackensack HS (NJ) | 0 | ? | |
| 1921 | W | Ridgewood HS (NJ) | 14 | Middletown HS (NJ) | 7 | ? | |
| 1921 | L | Ridgewood HS (NJ) | 7 | Montclair Military Academy (NJ) | 27 | ? | |
| 1921 | W | Ridgewood HS (NJ) | 14 | Passaic HS (NJ) | 7 | ? | |
| 1921 | W | Ridgewood HS (NJ) | 7 | Paterson HS (NJ) | 0 | ? | |
| 1921 | L | Ridgewood HS (NJ) | 2 | Rutherford HS (NJ) | 56 | ? | |
| 1921 | W | Ridgewood HS (NY) | 14 | Middletown HS (NY) | 7 | ? | |
| 1921 | W | Ridgway HS (PA) | 12 | Kane HS (PA) | 7 | ? | |
| 1921 | L | Ridgway HS (PA) | 10 | Kane HS (PA) | 12 | ? | |
| 1921 | T | Ridley Park HS (PA) | 7 | Chester HS (PA) | 7 | ? | |
| 1921 | W | Ridley Park HS (PA) | 7 | Darby HS (PA) | 0 | ? | |
| 1921 | L | Ridley Park HS (PA) | 0 | Germantown Friends School (PA) | 3 | ? | |
| 1921 | L | Ridley Park HS (PA) | 0 | Lansdowne HS (PA) | 28 | ? | |
| 1921 | W | Ridley Park HS (PA) | 7 | Lower Merion HS (PA) | 6 | ? | |
| 1921 | W | Ridley Park HS (PA) | 13 | Media HS (PA) | 7 | ? | |
| 1921 | W | Ridley Park HS (PA) | 6 | Phoenixville HS (PA) | 0 | ? | |
| 1921 | T | Ridley Park HS (PA) | 0 | Ridley Park HS Alumni (PA) | 0 | ? | |
| 1921 | W | Ridley Park HS (PA) | 13 | Swarthmore HS (PA) | 0 | ? | |
| 1921 | T | Ridley Park HS Alumni (PA) | 0 | Ridley Park HS (PA) | 0 | ? | |
| 1921 | W | Rindge Tech (MA) | 21 | Brookline HS (MA) | 0 | ? | |
| 1921 | L | Rindge Tech (MA) | 0 | Cambridge Latin & HS (MA) | 3 | ? | |
| 1921 | W | Rindge Tech (MA) | 15 | Everett HS (MA) | 7 | ? | |
| 1921 | L | Rindge Tech (MA) | 0 | Malden HS (MA) | 10 | ? | |
| 1921 | T | Rindge Tech (MA) | 0 | Medford HS (MA) | 0 | ? | |
| 1921 | L | Rindge Tech (MA) | 0 | Newton North HS (MA) | 16 | ? | |
| 1921 | W | Rio Grande (OH) | 48 | Cedarville (OH) | 0 | ? | |
| 1921 | L | Rio Grande (OH) | 0 | Charleston (WV) | 33 | Barboursville, WV | |
| 1921 | W | Rio Grande (OH) | 17 | Doane Academy (OH) | 0 | ? | |
| 1921 | L | Rio Grande (OH) | 3 | Marshall (WV) | 33 | ? | |
| 1921 | W | Rio Grande (OH) | 58 | Murray City HS (OH) | 0 | ? | |
| 1921 | L | Rio Grande (OH) | 14 | Muskingum (OH) | 27 | New Concord, OH | |
| 1921 | L | Rio Grande (OH) | 0 | Salem College (WV) | 37 | ? | |
| 1921 | W | Rio Grande (OH) | 21 | West Virginia Tech | 0 | ? | |
| 1921 | L | Ripon (WI) | 9 | Beloit (WI) | 16 | Beloit, WI | |
| 1921 | W | Ripon (WI) | 61 | Carroll (WI) | 0 | Ripon, WI | |
| 1921 | W | Ripon (WI) | 28 | Northwestern (WI) | 0 | Ripon, WI | |
| 1921 | W | Ripon (WI) | 21 | Wisconsin-Oshkosh | 6 | Ripon, WI | |
| 1921 | T | Ripon (WI) | 0 | Marquette (WI) | 0 | Milwaukee, WI | |
| 1921 | L | Ripon (WI) | 3 | Lawrence (WI) | 7 | Appleton, WI | |
| 1921 | L | Ripon HS (WI) | 0 | Wayland Academy (WI) | 20 | ? | |
| 1921 | L | Ripon JV (WI) | 6 | Saint John's Military Academy (WI) | 83 | ? | |
| 1921 | L | RISD | 0 | Providence (RI) | 87 | Providence, RI | Hope High School |
| 1921 | L | River Falls HS (WI) | 0 | Red Wing HS (MN) | 42 | ? | |
| 1921 | L | River Falls HS (WI) | 0 | Stillwater HS (MN) | 20 | ? | |
| 1921 | L | Riverdale School (NJ) | 0 | Pingry School (NJ) | 69 | ? | |
| 1921 | L | Riverside HS (CA) | 0 | Chaffee HS (CA) | 24 | ? | |
| 1921 | L | Riverside HS (CA) | 0 | Chaffee HS (CA) | 6 | ? | |
| 1921 | L | Riverside HS (IL) | 0 | Deerfield Shields HS (IL) | 28 | ? | |
| 1921 | L | Riverside HS (IL) | 13 | Proviso Township HS (IL) | 27 | ? | |
| 1921 | L | Riverside HS (IL) | 7 | Thornton HS (IL) | 14 | ? | |
| 1921 | W | Riverside JC (CA) | 19 | San Diego St. (CA) | 7 | Riverside, CA | Riverside Poly HS Field |
| 1921 | W | Riverside Military Academy (GA) | 38 | Atlanta Boy's HS (GA) | 0 | ? | |
| 1921 | L | RJSC | 7 | Saint Joseph's (IN) | 28 | ? | |
| 1921 | L | Roanoke (VA) | 6 | Hampden-Sydney (VA) | 14 | Roanoke, VA | |
| 1921 | L | Roanoke (VA) | 0 | King College (TN) | 7 | Bristol, TN | |
| 1921 | L | Roanoke (VA) | 7 | Lynchburg (VA) | 8 | Lynchburg, VA | |
| 1921 | L | Roanoke (VA) | 0 | Maryville (TN) | 16 | Bluefield, VA | |
| 1921 | W | Roanoke (VA) | 41 | Randolph-Macon Academy (VA) | 0 | ? | |
| 1921 | L | Roanoke (VA) | 0 | Virginia Military Institute | 13 | Lexington, VA | |
| 1921 | L | Roanoke (VA) | 0 | Virginia Tech | 35 | Blacksburg, VA | |
| 1921 | W | Roanoke (VA) | 14 | Guilford (NC) | 0 | Salem, VA | |
| 1921 | W | Roanoke (VA) | 33 | Emory & Henry (VA) | 14 | Salem, VA | |
| 1921 | L | Roanoke (VA) | 0 | Washington & Lee (VA) | 41 | Lexington, VA | |
| 1921 | W | Roanoke HS (VA) | 13 | Blacksburg HS (VA) | 6 | ? | |
| 1921 | W | Roanoke HS (VA) | 53 | Bristol HS (VA) | 7 | ? | |
| 1921 | W | Roanoke HS (VA) | 34 | Charlottesville HS (VA) | 0 | ? | |
| 1921 | W | Roanoke HS (VA) | 25 | Christiansburg Institute (VA) | 0 | ? | |
| 1921 | T | Roanoke HS (VA) | 0 | Danville HS (VA) | 0 | ? | |
| 1921 | W | Roanoke HS (VA) | 3 | Lynchburg HS (VA) | 0 | ? | |
| 1921 | W | Roanoke HS (VA) | 107 | Martinsville HS (VA) | 2 | ? | |
| 1921 | L | Roanoke HS (VA) | 0 | Norfolk Maury HS (VA) | 28 | ? | |
| 1921 | W | Roanoke HS (VA) | 20 | Salem HS (VA) | 0 | ? | |
| 1921 | L | Roanoke HS (VA) | 0 | Virginia Episcopal School (VA) | 13 | ? | |
| 1921 | L | Roanoke HS (VA) | 0 | Washington & Lee Freshmen (VA) | 14 | ? | |
| 1921 | L | Roaring Springs HS (PA) | 0 | Altoona HS (PA) | 47 | ? | |
| 1921 | L | Roaring Springs HS (PA) | 6 | Curwensville HS (PA) | 57 | ? | |
| 1921 | L | Rochester (NY) | 0 | Clarkson (NY) | 6 | Potsdam, NY | |
| 1921 | L | Rochester (NY) | 0 | Hobart (NY) | 14 | Rochester, NY | |
| 1921 | W | Rochester (NY) | 6 | Rensselaer Tech (NY) | 3 | Rochester, NY | |
| 1921 | W | Rochester (NY) | 29 | Saint Lawrence (NY) | 0 | Rochester, NY | |
| 1921 | W | Rochester (NY) | 28 | Union (NY) | 7 | Schenectady, NY | |
| 1921 | W | Rochester (NY) | 7 | Niagara (NY) | 0 | Rochester, NY | |
| 1921 | L | Rochester (NY) | 0 | Colgate (NY) | 41 | Hamilton, NY | |
| 1921 | L | Rochester (NY) | 0 | Cornell (NY) | 55 | Ithaca, NY | |
| 1921 | W | Rochester (NY) | 7 | Hamilton (NY) | 0 | Rochester, NY | |
| 1921 | T | Rochester C&T College (MN) | 14 | Winona St. (MN) | 14 | ? | |
| 1921 | W | Rochester Freshmen (NY) | 7 | Rochester Tech (NY) | 0 | ? | |
| 1921 | W | Rochester HS (MN) | 13 | Faribault HS (MN) | 0 | ? | |
| 1921 | W | Rochester HS (MN) | 20 | Kasson HS (MN) | 0 | ? | |
| 1921 | W | Rochester HS (MN) | 1 | Lake City HS (MN) | 0 | ? | Lake City HS Forfeits |
| 1921 | L | Rochester HS (MN) | 7 | Mankato HS (MN) | 21 | ? | |
| 1921 | W | Rochester HS (MN) | 36 | Pillsbury Military Academy (MN) | 0 | ? | |
| 1921 | W | Rochester HS (MN) | 17 | Red Wing HS (MN) | 7 | ? | |
| 1921 | L | Rochester HS (NH) | 0 | Phillips Exeter Academy (NH) | 7 | ? | |
| 1921 | W | Rochester HS (PA) | 35 | Beaver Falls HS (PA) | 6 | ? | |
| 1921 | W | Rochester HS (PA) | 61 | Beaver HS (PA) | 0 | ? | |
| 1921 | W | Rochester HS (PA) | 13 | Carnegie Mellon JV (PA) | 7 | ? | |
| 1921 | W | Rochester HS (PA) | 62 | Charleroi HS (PA) | 3 | ? | |
| 1921 | W | Rochester HS (PA) | 31 | Ellwood City HS (PA) | 7 | ? | |
| 1921 | W | Rochester HS (PA) | 18 | Monaca HS (PA) | 0 | ? | |
| 1921 | W | Rochester HS (PA) | 7 | Monessen HS (PA) | 6 | ? | |
| 1921 | W | Rochester HS (PA) | 6 | New Brighton HS (PA) | 0 | ? | |
| 1921 | W | Rochester HS (PA) | 47 | Parnassus HS | 0 | ? | |
| 1921 | W | Rochester HS (PA) | 13 | Rochester HS Alumni (PA) | 6 | ? | |
| 1921 | T | Rochester HS (PA) | 0 | Westinghouse HS (PA) | 0 | ? | |
| 1921 | W | Rochester HS (PA) | 34 | Woodlawn HS | 7 | ? | |
| 1921 | L | Rochester HS Alumni (PA) | 6 | Rochester HS (PA) | 13 | ? | |
| 1921 | L | Rochester JV (NY) | 0 | Rochester Tech (NY) | 14 | ? | |
| 1921 | L | Rochester JV (NY) | 0 | Saint John's Military Academy (NY) | 34 | ? | |
| 1921 | L | Rochester Optometry (NY) | 0 | Clarkson (NY) | 45 | Potsdam, NY | |
| 1921 | T | Rochester Optometry (NY) | 0 | Niagara (NY) | 0 | ? | |
| 1921 | W | Rochester Optometry (NY) | 7 | Rochester Tech (NY) | 0 | ? | |
| 1921 | L | Rochester Optometry (NY) | 0 | Canisius (NY) | 28 | Buffalo, NY | |
| 1921 | L | Rochester Tech (NY) | 0 | Alfred (NY) | 14 | ? | |
| 1921 | L | Rochester Tech (NY) | 0 | Canisius (NY) | 30 | Buffalo, NY | |
| 1921 | L | Rochester Tech (NY) | 0 | Clarkson (NY) | 45 | Potsdam, NY | |
| 1921 | W | Rochester Tech (NY) | 13 | Oswego St. (NY) | 0 | ? | |
| 1921 | L | Rochester Tech (NY) | 0 | Rochester Freshmen (NY) | 7 | ? | |
| 1921 | W | Rochester Tech (NY) | 14 | Rochester JV (NY) | 0 | ? | |
| 1921 | L | Rochester Tech (NY) | 0 | Rochester Optometry (NY) | 7 | ? | |
| 1921 | T | Rock Hill College (MD) | 0 | Calvert Hall | 0 | ? | |
| 1921 | L | Rock Hill College (MD) | 3 | Charlotte Hall Military Academy (MD) | 24 | ? | |
| 1921 | W | Rock Hill College (MD) | 34 | Ellicott City HS (MD) | 0 | ? | |
| 1921 | L | Rock Hill College (MD) | 7 | Saint John's (MD) | 13 | Ellicott City, MD | |
| 1921 | L | Rock Hill College (MD) | 0 | Washington Business HS (DC) | 60 | ? | |
| 1921 | W | Rock Hill College (MD) | 7 | Wilkens AA | 0 | ? | |
| 1921 | L | Rockford HS (IL) | 0 | Elgin HS (IL) | 6 | ? | |
| 1921 | W | Rockford HS (IL) | 26 | Freeport HS (IL) | 15 | ? | |
| 1921 | L | Rockhurst (MO) | 0 | Benedictine (KS) | 35 | ? | |
| 1921 | L | Rockland HS (MA) | 0 | Quincy HS (MA) | 29 | ? | |
| 1921 | T | Rocky Ford HS (CO) | 9 | La Junta HS (CO) | 9 | ? | |
| 1921 | L | Rocky Ford HS (CO) | 6 | La Junta HS (CO) | 7 | ? | |
| 1921 | L | Rocky Ford HS (CO) | 0 | Pueblo Central HS (CO) | 6 | ? | |
| 1921 | L | Rocky Mount HS (NC) | 0 | Fayetteville HS (NC) | 48 | ? | |
| 1921 | L | Rocky Mount HS (NC) | 0 | New Bern HS (NC) | 32 | ? | |
| 1921 | W | Rocky Mount HS (NC) | 42 | Raleigh HS (NC) | 0 | ? | |
| 1921 | T | Rocky Mount HS (NC) | 13 | Red Oak HS (NC) | 13 | ? | |
| 1921 | L | Rocky Mount HS (NC) | 0 | Red Oak HS (NC) | 32 | ? | |
| 1921 | W | Rocky Mount HS (NC) | 14 | Warsaw HS (NC) | 7 | ? | |
| 1921 | W | Rocky Mount HS (NC) | 48 | Wilson HS (NC) | 7 | ? | |
| 1921 | W | Rocky Mount HS (NC) | 54 | Wilson HS (NC) | 7 | ? | |
| 1921 | L | Roff American Legion | 0 | Southeastern Oklahoma St. | 48 | ? | |
| 1921 | W | Roger Williams (TN) | 12 | Nashville Pearl HS (TN) | 0 | ? | |
| 1921 | L | Roger Williams (TN) | 0 | Wilberforce (OH) | 20 | ? | |
| 1921 | W | Rogers HS (AR) | 26 | Bentonville HS (AR) | 12 | ? | |
| 1921 | L | Rogers HS (AR) | 13 | Bentonville HS (AR) | 19 | ? | |
| 1921 | W | Rogers HS (AR) | 24 | Fayetteville HS (AR) | 0 | ? | |
| 1921 | L | Rogers HS (AR) | 0 | Monett HS (MO) | 56 | ? | |
| 1921 | W | Rogers HS (AR) | 40 | Prairie Grove HS (AR) | 3 | ? | |
| 1921 | W | Rogers HS (AR) | 25 | Siloam Springs HS (AR) | 14 | ? | |
| 1921 | W | Rogers HS (AR) | 60 | Siloam Springs HS (AR) | 0 | ? | |
| 1921 | W | Rogers HS (AR) | 10 | University of Arkansas HS | 7 | ? | |
| 1921 | L | Rogers HS (AR) | 0 | Van Buren HS (AR) | 7 | ? | |
| 1921 | W | Rollins (FL) | 3 | Birmingham-Southern (AL) | 0 | Tampa, FL | |
| 1921 | W | Rollins (FL) | 41 | College of Charleston (SC) | 0 | ? | |
| 1921 | T | Rollins (FL) | 0 | Orlando American Legion (FL) | 0 | ? | |
| 1921 | W | Rollins (FL) | 31 | Orlando American Legion (FL) | 6 | Winter Park, FL | |
| 1921 | W | Rollins (FL) | 33 | Sanford Legion | 0 | ? | |
| 1921 | W | Rollins (FL) | 13 | Stetson (FL) | 0 | Deland, FL | |
| 1921 | L | Rollins (FL) | 0 | Florida | 33 | Orlando, FL | |
| 1921 | L | Rome Free Academy (NY) | 0 | Cazenovia Seminary (NY) | 21 | Cazenovia, NY | |
| 1921 | W | Rome Free Academy (NY) | 13 | Herkimer HS (NY) | 0 | ? | |
| 1921 | L | Rome Free Academy (NY) | 0 | Sherrill HS (NY) | 13 | ? | |
| 1921 | L | Ronceverte HS (WV) | 13 | Hinton HS (WV) | 19 | ? | |
| 1921 | L | Roodhouse HS (IL) | 0 | Pittsfield HS (IL) | 34 | ? | |
| 1921 | L | Rosary HS | 0 | Haverhill Saint James HS (MA) | 42 | ? | |
| 1921 | L | Roseburg HS (OR) | 0 | Ashland HS (OR) | 54 | ? | |
| 1921 | T | Rose-Hulman Tech (IN) | 7 | Culver Military Academy (IN) | 7 | Culver, IN | |
| 1921 | L | Rose-Hulman Tech (IN) | 0 | Eastern Illinois | 28 | Charleston, IL | |
| 1921 | W | Rose-Hulman Tech (IN) | 10 | Franklin (IN) | 0 | ? | |
| 1921 | W | Rose-Hulman Tech (IN) | 49 | Hanover (IN) | 17 | ? | |
| 1921 | W | Rose-Hulman Tech (IN) | 19 | Indiana St. | 0 | ? | |
| 1921 | L | Rose-Hulman Tech (IN) | 0 | Xavier (OH) | 49 | Cincinnati, OH | |
| 1921 | W | Rose-Hulman Tech (IN) | 7 | Missouri S&T | 3 | Rolla, MO | |
| 1921 | T | Rose-Hulman Tech (IN) | 0 | Eastern Illinois | 0 | Charleston, IL | |
| 1921 | L | Rose-Hulman Tech (IN) | 6 | Butler (IN) | 70 | Indianapolis, IN | |
| 1921 | L | Rose-Hulman Tech (IN) | 0 | Wabash (IN) | 39 | Crawfordsville, IN | |
| 1921 | W | Roselle HS (NJ) | 26 | Cranford HS (NJ) | 0 | ? | |
| 1921 | W | Roselle HS (NJ) | 14 | Metuchen HS (NJ) | 13 | ? | |
| 1921 | L | Roselle HS (NJ) | 0 | Rahway HS (NJ) | 33 | ? | |
| 1921 | L | Roselle HS (NJ) | 0 | Roselle Park HS (NJ) | 29 | ? | |
| 1921 | L | Roselle HS (NJ) | 7 | Somerville HS (NJ) | 20 | ? | |
| 1921 | L | Roselle HS (NJ) | 0 | Summit HS (NJ) | 13 | ? | |
| 1921 | L | Roselle HS (NJ) | 0 | Westfield HS (NJ) | 15 | ? | |
| 1921 | W | Roselle Park HS (NJ) | 65 | Cranford HS (NJ) | 0 | ? | |
| 1921 | L | Roselle Park HS (NJ) | 10 | Pingry School (NJ) | 42 | ? | |
| 1921 | L | Roselle Park HS (NJ) | 0 | Rahway HS (NJ) | 13 | ? | |
| 1921 | W | Roselle Park HS (NJ) | 29 | Roselle HS (NJ) | 0 | ? | |
| 1921 | W | Roselle Park HS (NJ) | 27 | Roselle Park HS Alumni (NJ) | 0 | ? | |
| 1921 | L | Roselle Park HS (NJ) | 0 | Summit HS (NJ) | 27 | ? | |
| 1921 | W | Roselle Park HS (NJ) | 12 | West Orange HS (NJ) | 7 | ? | |
| 1921 | T | Roselle Park HS (NJ) | 7 | Westfield HS (NJ) | 7 | ? | |
| 1921 | L | Roselle Park HS Alumni (NJ) | 0 | Roselle Park HS (NJ) | 27 | ? | |
| 1921 | W | Roswell HS (NM) | 39 | Albuquerque HS (NM) | 0 | ? | |
| 1921 | W | Roswell HS (NM) | 20 | Artesia HS (NM) | 0 | ? | |
| 1921 | W | Roswell HS (NM) | 29 | Artesia HS (NM) | 0 | ? | |
| 1921 | W | Roswell HS (NM) | 25 | Clovis HS (NM) | 0 | ? | |
| 1921 | W | Roswell HS (NM) | 14 | Clovis HS (NM) | 0 | ? | |
| 1921 | W | Roswell HS (NM) | 66 | Portales HS (NM) | 0 | ? | |
| 1921 | W | Roswell HS (NM) | 33 | Portales HS (NM) | 0 | ? | |
| 1921 | T | Round Valley Independents (CA) | 7 | Bishop HS (CA) | 7 | ? | |
| 1921 | L | Round Valley Independents (CA) | 0 | Bishop HS (CA) | 36 | ? | |
| 1921 | L | Roundup HS (MT) | 0 | Forsyth HS (MT) | 65 | ? | |
| 1921 | L | Roundup HS (MT) | 0 | Harlowton HS (MT) | 133 | ? | |
| 1921 | L | Roundup HS (MT) | 6 | Harlowton HS (MT) | 7 | ? | |
| 1921 | W | Roxbury HS (MA) | 14 | Hopkins Grammar School (CT) | 2 | ? | |
| 1921 | W | Roxbury HS (MA) | 35 | Pomfret School (CT) | 0 | ? | |
| 1921 | L | Roxbury HS (NJ) | 0 | Bernards HS (NJ) | 55 | ? | |
| 1921 | L | Roxbury HS (NJ) | 0 | Dover HS (NJ) | 49 | ? | |
| 1921 | W | Roxbury HS (NJ) | 21 | Hackettstown HS (NJ) | 0 | ? | |
| 1921 | L | Roxbury HS (NJ) | 0 | Newton HS (NJ) | 19 | ? | |
| 1921 | T | Roxbury Latin School (MA) | 14 | Browne & Nichols School (MA) | 14 | ? | |
| 1921 | L | Roxbury Latin School (MA) | 0 | Country Day School (MA) | 7 | ? | |
| 1921 | W | Roxbury Latin School (MA) | 7 | Governor Dummer Academy (MA) | 6 | ? | |
| 1921 | W | Roxbury Latin School (MA) | 14 | Noble & Greenough (MA) | 0 | ? | |
| 1921 | L | Roxbury Latin School (MA) | 12 | Saint George Academy | 13 | ? | |
| 1921 | L | Roxbury Latin School (MA) | 0 | Thayer Academy (MA) | 3 | ? | |
| 1921 | L | Roxbury School (CT) | 0 | Choate School | 3 | ? | |
| 1921 | W | Roxbury School (CT) | 14 | Hopkins Grammar School (CT) | 2 | ? | |
| 1921 | L | Roxbury School (CT) | 6 | Milford HS (CT) | 7 | ? | |
| 1921 | W | Roxbury School (CT) | 35 | Pomfret School (CT) | 0 | ? | |
| 1921 | L | Roxbury School (CT) | 7 | Suffield School (CT) | 21 | ? | |
| 1921 | W | Roxbury School (CT) | 16 | Yale Freshmen (CT) | 0 | ? | |
| 1921 | W | Royal Oak HS (MI) | 13 | Detroit Northeastern HS (MI) | 0 | ? | |
| 1921 | L | Rushford HS (MN) | 0 | Lanesboro HS (MN) | 26 | ? | |
| 1921 | L | Rushford HS (MN) | 0 | Lanesboro HS (MN) | 63 | ? | |
| 1921 | W | Rusk Baptist College (TX) | 6 | College of Marshall (TX) | 0 | ? | Rusk Baptist College won - score unknown |
| 1921 | L | Rusk Baptist College (TX) | 7 | Wesley College (TX) | 17 | ? | |
| 1921 | W | Russellville HS (AR) | 7 | Clarksville HS (AR) | 0 | ? | |
| 1921 | W | Russellville HS (AR) | 21 | Conway HS (AR) | 0 | ? | |
| 1921 | W | Russellville HS (AR) | 35 | Conway HS (AR) | 0 | ? | |
| 1921 | W | Russellville HS (AR) | 40 | Dardanelle HS (AR) | 0 | ? | |
| 1921 | W | Russellville HS (AR) | 57 | Morrilton HS (AR) | 6 | ? | |
| 1921 | W | Russellville HS (AR) | 91 | Ozark HS (AR) | 0 | ? | |
| 1921 | W | Russellville HS (AR) | 97 | Ozark HS (AR) | 0 | ? | |
| 1921 | W | Russellville HS (AR) | 46 | Pottsville HS (AR) | 0 | ? | |
| 1921 | W | Russellville HS (AR) | 21 | Van Buren HS (AR) | 0 | ? | |
| 1921 | L | Rust (MS) | 0 | Fisk (TN) | 33 | ? | |
| 1921 | W | Rust (MS) | 19 | Tougaloo (MS) | 0 | ? | |
| 1921 | L | Rutgers (NJ) | 14 | Georgia Tech | 48 | Atlanta, GA | |
| 1921 | L | Rutgers (NJ) | 0 | Lafayette (PA) | 35 | Easton, PA | |
| 1921 | W | Rutgers (NJ) | 33 | Ursinus (PA) | 0 | Collegeville, PA | |
| 1921 | W | Rutgers (NJ) | 14 | Washington & Lee (VA) | 13 | New Brunswick, NJ | |
| 1921 | W | Rutgers (NJ) | 17 | West Virginia | 7 | New Brunswick, NJ | |
| 1921 | L | Rutgers (NJ) | 0 | Maryland | 3 | New Brunswick, NJ | |
| 1921 | L | Rutgers (NJ) | 0 | Lehigh (PA) | 7 | New Brunswick, NJ | |
| 1921 | L | Rutgers (NJ) | 0 | Notre Dame (IN) | 48 | New York, NY | |
| 1921 | W | Rutgers (NJ) | 21 | New York (NY) | 7 | New York, NY | Ohio Field |
| 1921 | W | Rutgers Prep School (NJ) | 44 | Bordentown Military Institute (NJ) | 0 | ? | |
| 1921 | W | Rutgers Prep School (NJ) | 7 | Brooklyn Boys HS (NY) | 6 | ? | |
| 1921 | W | Rutgers Prep School (NJ) | 14 | Montclair Military Academy (NJ) | 7 | ? | |
| 1921 | L | Rutgers Prep School (NJ) | 0 | New Brunswick HS (NJ) | 16 | ? | |
| 1921 | L | Rutgers Prep School (NJ) | 0 | Princeton Prep School (NJ) | 13 | ? | |
| 1921 | W | Rutgers Prep School (NJ) | 7 | Somerville HS (NJ) | 0 | ? | |
| 1921 | L | Rutgers Prep School (NJ) | 6 | Trenton HS (NJ) | 7 | ? | |
| 1921 | L | Rutherford East HS (NJ) | 6 | Clifton HS (NJ) | 13 | ? | |
| 1921 | L | Rutherford East HS (NJ) | 0 | Spring Valley HS (NY) | 17 | ? | |
| 1921 | T | Rutherford East HS (NJ) | 7 | Union Hill HS (NJ) | 7 | ? | |
| 1921 | T | Rutherford East HS (NJ) | 0 | West Orange HS (NJ) | 0 | ? | |
| 1921 | W | Rutherford HS (NJ) | 12 | Asbury Park HS (NJ) | 3 | ? | |
| 1921 | W | Rutherford HS (NJ) | 28 | Cliffside Park HS (NJ) | 7 | ? | |
| 1921 | W | Rutherford HS (NJ) | 35 | Englewood HS (NJ) | 7 | ? | |
| 1921 | W | Rutherford HS (NJ) | 42 | Hackensack HS (NJ) | 0 | ? | |
| 1921 | W | Rutherford HS (NJ) | 35 | Long Branch Chattle HS (NJ) | 0 | ? | |
| 1921 | W | Rutherford HS (NJ) | 28 | Montclair HS (NJ) | 0 | ? | |
| 1921 | W | Rutherford HS (NJ) | 10 | Newark Central HS (NJ) | 0 | ? | |
| 1921 | W | Rutherford HS (NJ) | 10 | Newark Central HS (NJ) | 6 | ? | |
| 1921 | W | Rutherford HS (NJ) | 34 | Passaic HS (NJ) | 0 | ? | |
| 1921 | W | Rutherford HS (NJ) | 42 | Phillipsburg HS (NJ) | 0 | ? | |
| 1921 | W | Rutherford HS (NJ) | 56 | Ridgewood HS (NJ) | 2 | ? | |
| 1921 | L | Rye HS (NY) | 0 | Port Chester HS (NY) | 18 | ? | |
| 1921 | L | S.C.I. | 0 | Fishburne Military School (VA) | 28 | ? | |
| 1921 | W | Sacramento HS (CA) | 48 | Alameda HS (CA) | 8 | ? | |
| 1921 | L | Sacramento HS (CA) | 7 | Berkeley HS (CA) | 28 | ? | |
| 1921 | L | Sacramento HS (CA) | 14 | Berkeley HS (CA) | 49 | ? | |
| 1921 | L | Sacramento HS (CA) | 7 | Cal St.-Chico | 14 | ? | |
| 1921 | W | Sacramento HS (CA) | 20 | Glenn County HS (CA) | 0 | ? | |
| 1921 | L | Sacramento HS (CA) | 12 | Preston Industrial School (CA) | 14 | ? | |
| 1921 | W | Sacramento HS (CA) | 20 | Stockton HS (CA) | 7 | ? | |
| 1921 | W | Sacramento HS (CA) | 39 | Stockton HS (CA) | 0 | ? | |
| 1921 | W | Sacramento HS (CA) | 20 | Willows HS (CA) | 0 | ? | |
| 1921 | W | Sacramento HS (CA) | 55 | Woodland HS (CA) | 7 | ? | |
| 1921 | W | Sacramento HS (CA) | 68 | Woodland HS (CA) | 0 | ? | |
| 1921 | L | Sacred Heart College (CA) | 7 | Potter School (CA) | 33 | ? | |
| 1921 | L | Sacred Heart College (CA) | 14 | San Francisco HS of Commerce (CA) | 48 | ? | |
| 1921 | L | Sacred Heart College (CA) | 0 | San Francisco Lick Wilmerling HS (CA) | 33 | ? | |
| 1921 | L | Sacred Heart College (CA) | 12 | San Francisco University School (CA) | 24 | ? | |
| 1921 | L | Sacred Heart College (CA) | 0 | Santa Clara University HS (CA) | 72 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 21 | Battle Creek Eastern HS (MI) | 0 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 14 | Battle Creek HS (MI) | 6 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 1 | Benton Harbor HS (MI) | 0 | ? | Benton Harbor HS Forfeits |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 35 | Detroit Central HS (MI) | 0 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 14 | Lansing HS (MI) | 0 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 47 | Lapeer HS (MI) | 6 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 64 | Owosso HS (MI) | 0 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 6 | Port Huron HS (MI) | 0 | ? | |
| 1921 | L | Saginaw Arthur Hill HS (MI) | 0 | Saginaw East HS (MI) | 10 | ? | |
| 1921 | W | Saginaw Arthur Hill HS (MI) | 24 | Traverse City HS (MI) | 0 | ? | |
| 1921 | W | Saginaw East HS (MI) | 16 | Alma HS (MI) | 0 | ? | |
| 1921 | W | Saginaw East HS (MI) | 25 | Bay City Eastern HS (MI) | 6 | ? | |
| 1921 | W | Saginaw East HS (MI) | 52 | Bay City Western HS (MI) | 0 | ? | |
| 1921 | W | Saginaw East HS (MI) | 44 | Calumet HS (MI) | 7 | ? | |
| 1921 | L | Saginaw East HS (MI) | 10 | Detroit Northwestern HS (MI) | 38 | ? | |
| 1921 | W | Saginaw East HS (MI) | 26 | Grand Rapids Central HS (MI) | 0 | ? | |
| 1921 | W | Saginaw East HS (MI) | 7 | Lansing HS (MI) | 0 | ? | |
| 1921 | W | Saginaw East HS (MI) | 20 | Owosso HS (MI) | 12 | ? | |
| 1921 | W | Saginaw East HS (MI) | 55 | Port Huron HS (MI) | 7 | ? | |
| 1921 | W | Saginaw East HS (MI) | 10 | Saginaw Arthur Hill HS (MI) | 0 | ? | |
| 1921 | L | Saint Albans HS | 0 | Charleston HS (WV) | 20 | ? | |
| 1921 | L | Saint Albans School | 6 | Saint James Prep School (MD) | 7 | ? | |
| 1921 | W | Saint Ambrose (IA) | 14 | Campion College (WI) | 0 | Prairie du Chien, WI | |
| 1921 | L | Saint Ambrose (IA) | 0 | Kirksville Osteopath (MO) | 19 | Kirksville, MO | |
| 1921 | W | Saint Ambrose (IA) | 46 | Quincy (IL) | 0 | Davenport, IA | |
| 1921 | L | Saint Ambrose (IA) | 7 | Wisconsin-Platteville | 9 | Davenport, IA | |
| 1921 | W | Saint Ambrose (IA) | 26 | Davenport Battery B (IA) | 0 | Davenport, IA | |
| 1921 | L | Saint Ambrose (IA) | 0 | Augustana (IL) | 14 | Rock Island, IL | |
| 1921 | T | Saint Ambrose (IA) | 7 | Still College (IA) | 7 | Des Moines, IA | |
| 1921 | L | Saint Anselm Prep | 0 | Cushing Academy (MA) | 6 | ? | |
| 1921 | T | Saint Anselm Prep | 0 | Haverhill Saint James HS (MA) | 0 | ? | |
| 1921 | L | Saint Anselm Prep | 0 | Saint John's Prep (MA) | 14 | ? | |
| 1921 | L | Saint Ansgar HS (IA) | 0 | Osage HS (IA) | 62 | ? | |
| 1921 | L | Saint Augustine's (NC) | 0 | Saint Paul's (VA) | 7 | ? | |
| 1921 | L | Saint Augustine's (NC) | 0 | Virginia-Lynchburg | 13 | ? | |
| 1921 | L | Saint Augustine's (NC) | 0 | Virginia St. | 7 | Petersburg, VA | |
| 1921 | L | Saint Benedict Prep School (NJ) | 0 | Fordham Prep (NY) | 21 | ? | |
| 1921 | L | Saint Benedict Prep School (NJ) | 0 | Freehold HS (NJ) | 7 | ? | |
| 1921 | L | Saint Benedict Prep School (NJ) | 7 | Newark Central HS (NJ) | 21 | ? | |
| 1921 | W | Saint Benedict Prep School (NJ) | 14 | Newark East Side HS (NJ) | 0 | ? | |
| 1921 | L | Saint Benedict Prep School (NJ) | 0 | Peddie Institute (NJ) | 41 | ? | |
| 1921 | W | Saint Benedict Prep School (NJ) | 13 | Pennington Seminary (NJ) | 7 | ? | |
| 1921 | L | Saint Benedict Prep School (NJ) | 3 | Saint Peter's Prep (NJ) | 6 | ? | |
| 1921 | T | Saint Benedict Prep School (NJ) | 0 | South Orange Columbia HS (NJ) | 0 | ? | |
| 1921 | L | Saint Benedict Prep School (NJ) | 7 | Stamford HS (CT) | 14 | ? | |
| 1921 | L | Saint Benedict Prep School (NJ) | 0 | Upsala (NJ) | 7 | ? | |
| 1921 | L | Saint Bernard JC (AL) | 13 | Bryson (TN) | 28 | Fayetteville, TN | |
| 1921 | T | Saint Bonaventure (NY) | 0 | Canisius (NY) | 0 | Saint Bonaventure, NY | |
| 1921 | W | Saint Bonaventure (NY) | 3 | Canisius (NY) | 0 | Saint Bonaventure, NY | |
| 1921 | L | Saint Bonaventure (NY) | 0 | Carnegie Mellon (PA) | 42 | Pittsburgh, PA | |
| 1921 | T | Saint Bonaventure (NY) | 7 | Colgate (NY) | 7 | Hamilton, NY | |
| 1921 | L | Saint Bonaventure (NY) | 3 | Niagara (NY) | 6 | Niagara Falls, NY | |
| 1921 | T | Saint Bonaventure (NY) | 0 | Westminster (PA) | 0 | New Wilmington, PA | |
| 1921 | L | Saint Bonaventure (NY) | 0 | Cornell (NY) | 41 | Ithaca, NY | |
| 1921 | L | Saint Bonaventure (NY) | 0 | Brown (RI) | 55 | Providence, RI | |
| 1921 | L | Saint Bonaventure (NY) | 0 | Grove City (PA) | 21 | Grove City, PA | |
| 1921 | W | Saint Bonaventure (NY) | 12 | Juniata (PA) | 0 | Saint Bonaventure, NY | YMCA Field |
| 1921 | W | Saint Charles (LA) | 28 | Centenary (LA) | 0 | ? | |
| 1921 | L | Saint Charles (LA) | 0 | Louisiana College | 6 | ? | |
| 1921 | T | Saint Charles (LA) | 0 | Northwestern St. (LA) | 0 | Grand Coteau, LA | |
| 1921 | L | Saint Charles (LA) | 21 | Louisiana-Lafayette | 40 | Lafayette, LA | |
| 1921 | W | Saint Charles (LA) | 21 | Loyola (LA) | 0 | New Orleans, LA | |
| 1921 | L | Saint Charles HS (MO) | 0 | Chaminade College HS (MO) | 26 | ? | |
| 1921 | L | Saint Charles HS (MO) | 7 | Webster Groves HS (MO) | 13 | ? | |
| 1921 | W | Saint Cloud HS (MN) | 27 | Anoka HS (MN) | 7 | ? | |
| 1921 | W | Saint Cloud HS (MN) | 19 | Little Falls HS (MN) | 6 | ? | |
| 1921 | T | Saint Cloud HS (MN) | 13 | Milaca HS (MN) | 13 | ? | |
| 1921 | T | Saint Cloud HS (MN) | 14 | Milaca HS (MN) | 14 | ? | |
| 1921 | W | Saint Cloud HS (MN) | 35 | Saint Paul Humboldt HS (MN) | 0 | ? | |
| 1921 | L | Saint Cloud HS (MN) | 0 | Stillwater HS (MN) | 13 | ? | |
| 1921 | L | Saint Cloud HS (MN) | 6 | Willmar HS (MN) | 7 | ? | |
| 1921 | L | Saint Cloud St. (MN) | 6 | Alexandria HS (MN) | 52 | ? | |
| 1921 | L | Saint Cloud St. (MN) | 13 | Little Falls HS (MN) | 17 | ? | |
| 1921 | L | Saint Cloud St. (MN) | 0 | Moorhead St. (MN) | 21 | ? | |
| 1921 | L | Saint Cloud St. (MN) | 0 | Saint John's (MN) | 28 | ? | |
| 1921 | W | Saint Cloud St. (MN) | 7 | Winona St. (MN) | 0 | ? | |
| 1921 | L | Saint Cloud St. (MN) | 0 | Wisconsin-Superior | 62 | ? | |
| 1921 | L | Saint Edward's (TX) | 0 | Dallas (TX) | 34 | Dallas, TX | |
| 1921 | W | Saint Edward's (TX) | 27 | San Marcos Baptist (TX) | 0 | ? | |
| 1921 | L | Saint Edward's (TX) | 7 | Texas St. | 31 | San Marcos, TX | |
| 1921 | L | Saint Edward's (TX) | 0 | Texas | 33 | Austin, TX | |
| 1921 | T | Saint Edward's (TX) | 0 | Daniel Baker (TX) | 0 | Brownwood, TX | |
| 1921 | L | Saint Francis (KS) | 0 | Yuma County HS (CO) | 6 | ? | |
| 1921 | L | Saint Francis (PA) | 0 | Altoona HS (PA) | 34 | ? | |
| 1921 | L | Saint Francis (PA) | 0 | Indiana (PA) | 19 | ? | |
| 1921 | L | Saint Francis de Sales | 7 | Cook Academy (NY) | 19 | ? | |
| 1921 | L | Saint Francis Xavier | 0 | Newman School (NJ) | 33 | ? | |
| 1921 | L | Saint Francis Xavier (NY) | 0 | Clason Military Academy (NY) | 14 | ? | |
| 1921 | W | Saint George Academy | 13 | Roxbury Latin School (MA) | 12 | ? | |
| 1921 | W | Saint George Academy | 3 | Thayer Academy (MA) | 0 | ? | |
| 1921 | L | Saint George HS | 0 | Middlesex School (MA) | 14 | ? | |
| 1921 | L | Saint George HS | 7 | Moses Brown School (RI) | 21 | ? | |
| 1921 | L | Saint Helens HS (OR) | 7 | Astoria HS (OR) | 27 | ? | |
| 1921 | W | Saint Ignatius College (OH) | 21 | Cleveland Central HS (OH) | 0 | ? | |
| 1921 | L | Saint Ignatius Prep (IL) | 0 | Loyola Academy (IL) | 7 | ? | |
| 1921 | L | Saint James Prep School (MD) | 0 | Baltimore Friends School (MD) | 21 | ? | |
| 1921 | W | Saint James Prep School (MD) | 24 | Frederick HS (MD) | 0 | ? | |
| 1921 | W | Saint James Prep School (MD) | 21 | Harrisburg Academy (PA) | 7 | ? | |
| 1921 | W | Saint James Prep School (MD) | 7 | Saint Albans School | 6 | ? | |
| 1921 | W | Saint James Prep School (MD) | 26 | Saint Luke's School (PA) | 0 | ? | |
| 1921 | W | Saint James Prep School (MD) | 40 | Shepherd (WV) | 0 | Saint James, MD | |
| 1921 | L | Saint John HS (KS) | 0 | Kingman HS (KS) | 46 | ? | |
| 1921 | L | Saint John's (MA) | 0 | Clinton HS (MA) | 33 | ? | |
| 1921 | W | Saint John's (MD) | 35 | Drexel Institute (PA) | 0 | Philadelphia, PA | |
| 1921 | L | Saint John's (MD) | 3 | Johns Hopkins (MD) | 17 | Baltimore, MD | |
| 1921 | L | Saint John's (MD) | 0 | Lebanon Valley (PA) | 6 | Annapolis, MD | |
| 1921 | W | Saint John's (MD) | 7 | Maryland | 3 | College Park, MD | |
| 1921 | W | Saint John's (MD) | 13 | Rock Hill College (MD) | 7 | Ellicott City, MD | |
| 1921 | L | Saint John's (MD) | 0 | Widener (PA) | 3 | Chester, PA | |
| 1921 | W | Saint John's (MD) | 29 | McDaniel College (MD) | 0 | Annapolis, MD | |
| 1921 | W | Saint John's (MD) | 31 | Gallaudet (DC) | 7 | Annapolis, MD | |
| 1921 | W | Saint John's (MD) | 58 | Washington (MD) | 7 | Chestertown, MD | |
| 1921 | L | Saint John's (MD) | 0 | Mount Saint Mary's (MD) | 6 | Emmitsburg, MD | |
| 1921 | L | Saint John's (MN) | 14 | Alexandria HS (MN) | 20 | ? | |
| 1921 | L | Saint John's (MN) | 0 | Hamline (MN) | 17 | ? | |
| 1921 | W | Saint John's (MN) | 28 | Saint Cloud St. (MN) | 0 | ? | |
| 1921 | L | Saint John's (MN) | 7 | Saint Mary's (MN) | 14 | Collegeville, MN | |
| 1921 | L | Saint John's (MN) | 0 | Macalester (MN) | 14 | Saint Paul, MN | |
| 1921 | T | Saint John's Academy | 0 | Buffalo Masten Park HS (NY) | 0 | ? | |
| 1921 | L | Saint John's American Legion (KS) | 7 | McPherson (KS) | 21 | McPherson, KS | |
| 1921 | L | Saint John's HS | 0 | Country Day School (WI) | 7 | ? | |
| 1921 | L | Saint John's HS | 0 | New York Erasmus Hall HS (NY) | 13 | ? | |
| 1921 | L | Saint John's HS | 0 | Saint John's Prep (MA) | 56 | ? | |
| 1921 | L | Saint John's Literary Institute (MA) | 0 | Haverhill Saint James HS (MA) | 51 | ? | |
| 1921 | W | Saint John's Military Academy (WI) | 10 | Carroll (WI) | 0 | Waukesha, WI | |
| 1921 | W | Saint John's Military Academy (WI) | 56 | Kemper Military School (MO) | 0 | ? | |
| 1921 | W | Saint John's Military Academy (WI) | 34 | Lawrence JV (WI) | 14 | ? | |
| 1921 | W | Saint John's Military Academy (WI) | 83 | Ripon JV (WI) | 6 | ? | |
| 1921 | W | Saint John's Military Academy (WI) | 28 | Wisconsin Tech | 0 | ? | |
| 1921 | L | Saint John's Military Academy (WI) | 0 | Wisconsin-Oshkosh | 28 | Oshkosh, WI | |
| 1921 | T | Saint John's Military School (KS) | 0 | Buffalo Masten Park HS (NY) | 0 | Manlius, NY | |
| 1921 | W | Saint John's Military School (KS) | 60 | Christian Brothers Academy (NY) | 14 | Manlius, NY | |
| 1921 | W | Saint John's Military School (KS) | 14 | Colgate Freshmen (NY) | 0 | ? | |
| 1921 | L | Saint John's Military School (KS) | 0 | Mansfield (PA) | 27 | Manlius, NY | |
| 1921 | W | Saint John's Military School (KS) | 28 | Massena HS (NY) | 13 | ? | |
| 1921 | W | Saint John's Military School (KS) | 20 | North Tonawanda HS (NY) | 0 | ? | |
| 1921 | L | Saint John's Military School (KS) | 0 | Oneida HS (NY) | 7 | ? | |
| 1921 | W | Saint John's Military School (KS) | 34 | Rochester JV (NY) | 0 | ? | |
| 1921 | L | Saint John's Prep (MA) | 0 | Haverhill HS (MA) | 19 | ? | |
| 1921 | W | Saint John's Prep (MA) | 67 | Mechanics Arts HS | 0 | ? | |
| 1921 | L | Saint John's Prep (MA) | 0 | Medford HS (MA) | 30 | ? | |
| 1921 | W | Saint John's Prep (MA) | 14 | MIT Freshmen (MA) | 0 | ? | |
| 1921 | T | Saint John's Prep (MA) | 0 | New Hampshire Freshmen | 0 | ? | |
| 1921 | W | Saint John's Prep (MA) | 14 | Saint Anselm Prep | 0 | ? | |
| 1921 | W | Saint John's Prep (MA) | 56 | Saint John's HS | 0 | ? | |
| 1921 | W | Saint John's Prep (MA) | 7 | Salem HS (MA) | 0 | ? | |
| 1921 | W | Saint John's Prep (MA) | 7 | Tufts Freshmen (MA) | 0 | ? | |
| 1921 | W | Saint John's Prep (MA) | 19 | Wakefield HS (MA) | 7 | ? | |
| 1921 | L | Saint John's Prep (NY) | 0 | Brooklyn Evening HS (NY) | 7 | ? | |
| 1921 | W | Saint John's Prep (NY) | 7 | Cooper Union (NY) | 0 | Brooklyn, NY | |
| 1921 | L | Saint John's Prep (NY) | 0 | Flushing HS (NY) | 7 | ? | |
| 1921 | L | Saint John's Prep (NY) | 0 | Peekskill Military Academy (NY) | 7 | ? | |
| 1921 | L | Saint Joseph HS (MI) | 0 | Grand Rapids Union HS (MI) | 40 | ? | |
| 1921 | L | Saint Joseph's (IN) | 6 | Benedictine (IL) | 14 | Lisle, IL | |
| 1921 | W | Saint Joseph's (IN) | 20 | Benedictine (IL) | 7 | Collegeville, IN | |
| 1921 | L | Saint Joseph's (IN) | 0 | Rensselaer Independents (IN) | 20 | ? | |
| 1921 | W | Saint Joseph's (IN) | 28 | RJSC | 7 | ? | |
| 1921 | W | Saint Joseph's (IN) | 29 | Saint Xavier's Hall | 0 | ? | |
| 1921 | W | Saint Joseph's (IN) | 1 | West Lafayette | 0 | ? | West Lafayette Forfeits |
| 1921 | L | Saint Joseph's (IN) | 0 | Valparaiso (IN) | 59 | Collegeville, IN | |
| 1921 | L | Saint Joseph's Prep School (PA) | 0 | Brooklyn Prep School (NY) | 6 | ? | |
| 1921 | W | Saint Joseph's Prep School (PA) | 63 | Brown Prep School (PA) | 0 | ? | |
| 1921 | W | Saint Joseph's Prep School (PA) | 16 | Germantown HS (PA) | 0 | ? | |
| 1921 | W | Saint Joseph's Prep School (PA) | 24 | Philadelphia Catholic HS (PA) | 0 | ? | |
| 1921 | W | Saint Joseph's Prep School (PA) | 7 | Philadelphia West Catholic HS (PA) | 6 | ? | |
| 1921 | W | Saint Joseph's Prep School (PA) | 21 | Saint Joseph's Prep School Alumni (PA) | 0 | ? | |
| 1921 | W | Saint Joseph's Prep School (PA) | 12 | Swarthmore Prep School (PA) | 6 | ? | |
| 1921 | L | Saint Joseph's Prep School (PA) | 0 | Villanova Prep School (PA) | 6 | ? | |
| 1921 | W | Saint Joseph's Prep School (PA) | 21 | Villanova Prep School (PA) | 10 | ? | |
| 1921 | L | Saint Joseph's Prep School Alumni (PA) | 0 | Saint Joseph's Prep School (PA) | 21 | ? | |
| 1921 | L | Saint Lawrence (NY) | 6 | Middlebury (VT) | 26 | Canton, NY | |
| 1921 | L | Saint Lawrence (NY) | 0 | Rochester (NY) | 29 | Rochester, NY | |
| 1921 | W | Saint Lawrence (NY) | 10 | Saint Stephen's College (NY) | 0 | Canton, NY | |
| 1921 | T | Saint Lawrence (NY) | 6 | Rensselaer Tech (NY) | 6 | Troy, NY | |
| 1921 | L | Saint Lawrence (NY) | 14 | Connecticut | 39 | Storrs, CT | |
| 1921 | L | Saint Lawrence (NY) | 7 | Union (NY) | 9 | Schenectady, NY | |
| 1921 | L | Saint Lawrence (NY) | 0 | Clarkson (NY) | 9 | Canton, NY | |
| 1921 | L | Saint Louis (MO) | 7 | DePauw (IN) | 21 | Saint Louis, MO | |
| 1921 | L | Saint Louis (MO) | 0 | Lombard (IL) | 61 | Saint Louis, MO | |
| 1921 | W | Saint Louis (MO) | 14 | Milwaukee School of Engineering (WI) | 13 | Saint Louis, MO | |
| 1921 | W | Saint Louis (MO) | 7 | Southeast Missouri St. | 0 | Saint Louis, MO | |
| 1921 | T | Saint Louis (MO) | 0 | Washington (MO) | 0 | Saint Louis, MO | |
| 1921 | W | Saint Louis (MO) | 12 | Kansas City (KS) | 0 | Saint Louis, MO | |
| 1921 | L | Saint Louis (MO) | 0 | Creighton (NE) | 21 | Omaha, NE | |
| 1921 | L | Saint Louis (MO) | 0 | Missouri | 32 | Saint Louis, MO | |
| 1921 | W | Saint Louis (MO) | 36 | Westminster (MO) | 0 | Saint Louis, MO | |
| 1921 | T | Saint Louis Central HS (MO) | 7 | Principia Academy (MO) | 7 | ? | |
| 1921 | L | Saint Louis College (TX) | 0 | San Marcos Baptist (TX) | 41 | ? | |
| 1921 | L | Saint Louis East HS (MO) | 0 | Webster Groves HS (MO) | 7 | ? | |
| 1921 | L | Saint Louis McKinley HS (MO) | 0 | Principia Academy (MO) | 35 | ? | |
| 1921 | W | Saint Louis University Academy (MO) | 49 | Chaminade College HS (MO) | 0 | ? | |
| 1921 | L | Saint Louis University HS (MO) | 0 | Missouri Military Academy | 68 | ? | |
| 1921 | L | Saint Louis Yeatman HS (MO) | 0 | Principia Academy (MO) | 27 | ? | |
| 1921 | W | Saint Luke's School (PA) | 14 | Chestnut Hill Academy (PA) | 7 | ? | |
| 1921 | L | Saint Luke's School (PA) | 0 | Episcopal Academy (PA) | 34 | ? | |
| 1921 | W | Saint Luke's School (PA) | 19 | Germantown Academy (PA) | 6 | ? | |
| 1921 | L | Saint Luke's School (PA) | 14 | Haverford College Grammer School (PA) | 33 | ? | |
| 1921 | W | Saint Luke's School (PA) | 16 | Haverford College Grammer School JV (PA) | 6 | ? | |
| 1921 | L | Saint Luke's School (PA) | 0 | Penn Charter School (PA) | 61 | ? | |
| 1921 | L | Saint Luke's School (PA) | 0 | Pennsylvania Institution for the Deaf | 104 | ? | |
| 1921 | L | Saint Luke's School (PA) | 0 | Saint James Prep School (MD) | 26 | ? | |
| 1921 | L | Saint Marks School (MA) | 0 | Cambridge Latin & HS (MA) | 20 | ? | |
| 1921 | L | Saint Marks School (MA) | 7 | Framingham HS (MA) | 41 | ? | |
| 1921 | W | Saint Marks School (MA) | 30 | Hudson HS (MA) | 0 | ? | |
| 1921 | W | Saint Marks School (MA) | 13 | Middlesex School (MA) | 6 | ? | |
| 1921 | L | Saint Marks School JV (MA) | 0 | Clinton HS (MA) | 6 | ? | |
| 1921 | T | Saint Martin's (WA) | 7 | 9th Aerial Corps | 7 | ? | |
| 1921 | L | Saint Martin's (WA) | 0 | Aberdeen American Legion (WA) | 13 | ? | |
| 1921 | W | Saint Martin's (WA) | 87 | Balloon Corps | 0 | ? | |
| 1921 | L | Saint Martin's (WA) | 0 | Chehalis HS (WA) | 3 | ? | |
| 1921 | W | Saint Martin's (WA) | 26 | Olympia HS (WA) | 0 | ? | |
| 1921 | L | Saint Martin's (WA) | 7 | Saint Martin's Freshmen (WA) | 42 | ? | |
| 1921 | L | Saint Martin's (WA) | 0 | Washington Freshmen | 30 | ? | |
| 1921 | L | Saint Martin's (WA) | 0 | Western Washington | 6 | Bellingham, WA | |
| 1921 | W | Saint Martin's Freshmen (WA) | 42 | Saint Martin's (WA) | 7 | ? | |
| 1921 | L | Saint Mary's (CA) | 0 | California | 21 | Berkeley, CA | |
| 1921 | W | Saint Mary's (CA) | 46 | Mare Island Marines (CA) | 6 | Vallejo, CA | |
| 1921 | W | Saint Mary's (CA) | 14 | Nevada | 6 | Reno, NV | |
| 1921 | L | Saint Mary's (CA) | 0 | Pacific Fleet (CA) | 20 | ? | |
| 1921 | W | Saint Mary's (CA) | 20 | San Francisco Olympic Club (CA) | 7 | ? | |
| 1921 | W | Saint Mary's (CA) | 68 | Santa Maria Legion | 0 | ? | |
| 1921 | L | Saint Mary's (CA) | 7 | Stanford (CA) | 10 | Stanford, CA | |
| 1921 | L | Saint Mary's (KS) | 0 | Emporia St. (KS) | 14 | ? | |
| 1921 | L | Saint Mary's (KS) | 7 | Fort Hays St. (KS) | 14 | Hays, KS | |
| 1921 | L | Saint Mary's (KS) | 7 | Ottawa (KS) | 10 | Saint Mary's, KS | |
| 1921 | W | Saint Mary's (KS) | 14 | Washburn (KS) | 3 | Topeka, KS | |
| 1921 | W | Saint Mary's (KS) | 14 | York (NE) | 7 | ? | |
| 1921 | L | Saint Mary's (KS) | 3 | Baker (KS) | 33 | Baldwin City, KS | |
| 1921 | W | Saint Mary's (KS) | 17 | McPherson (KS) | 14 | Saint Mary's, KS | |
| 1921 | L | Saint Mary's (KS) | 7 | Pittsburg St. (KS) | 13 | Saint Mary's, KS | |
| 1921 | L | Saint Mary's (MN) | 0 | Columbus (SD) | 14 | Sioux Falls, SD | |
| 1921 | L | Saint Mary's (MN) | 0 | Wisconsin-Eau Claire | 20 | Winona, MN | |
| 1921 | L | Saint Mary's (MN) | 0 | Wisconsin-River Falls | 21 | River Falls, WI | |
| 1921 | W | Saint Mary's (MN) | 34 | Saint Norbert (WI) | 0 | Winona, MN | |
| 1921 | W | Saint Mary's (MN) | 14 | Saint John's (MN) | 7 | Collegeville, MN | |
| 1921 | L | Saint Mary's (MN) | 0 | Saint Thomas (MN) | 7 | Saint Paul, MN | |
| 1921 | T | Saint Mary's (MN) | 7 | Wisconsin-Stout | 7 | Winona, MN | |
| 1921 | L | Saint Mary's (TX) | 0 | San Marcos Baptist (TX) | 41 | ? | |
| 1921 | L | Saint Mary's Academy | 0 | Massena HS (NY) | 19 | ? | |
| 1921 | L | Saint Mary's HS | 0 | Newman School (NJ) | 33 | ? | |
| 1921 | W | Saint Mary's HS | 18 | Richmond HS (OH) | 0 | ? | |
| 1921 | L | Saint Mary's HS (CA) | 0 | Berkeley HS (CA) | 48 | ? | |
| 1921 | L | Saint Marys HS (OH) | 6 | Delphos HS (OH) | 22 | ? | |
| 1921 | W | Saint Marys HS (OH) | 18 | Gettysburg HS (OH) | 0 | ? | |
| 1921 | L | Saint Marys HS (OH) | 0 | Lima South HS (OH) | 38 | ? | |
| 1921 | L | Saint Marys HS (OH) | 0 | Sidney HS (OH) | 53 | ? | |
| 1921 | L | Saint Marys HS (OH) | 0 | Sidney HS (OH) | 22 | ? | |
| 1921 | W | Saint Marys HS (OH) | 17 | Wapakoneta HS (OH) | 0 | ? | |
| 1921 | W | Saint Marys HS (OH) | 24 | Wapakoneta HS (OH) | 0 | ? | |
| 1921 | L | Saint Marys HS (WV) | 0 | Sistersville HS (WV) | 13 | ? | |
| 1921 | L | Saint Marys HS (WV) | 0 | Sistersville HS (WV) | 7 | ? | |
| 1921 | L | Saint Matthew's Prep | 0 | Villanova Prep School (PA) | 41 | ? | |
| 1921 | T | Saint Norbert (WI) | 6 | Menominee HS (MI) | 6 | De Pere, WI | |
| 1921 | W | Saint Norbert (WI) | 38 | Pio Nomo College (WI) | 0 | De Pere, WI | |
| 1921 | L | Saint Norbert (WI) | 0 | Wisconsin-Stevens Point | 108 | Stevens Point, WI | |
| 1921 | L | Saint Norbert (WI) | 0 | Saint Mary's (MN) | 34 | Winona, MN | |
| 1921 | L | Saint Norbert (WI) | 0 | Marquette Academy (WI) | 39 | Milwaukee, WI | |
| 1921 | L | Saint Norbert (WI) | 6 | Green Bay East HS (WI) | 27 | De Pere, WI | |
| 1921 | W | Saint Olaf (MN) | 14 | Gustavus Adolphus (MN) | 0 | Saint Peter, MN | |
| 1921 | W | Saint Olaf (MN) | 10 | Luther (IA) | 0 | ? | |
| 1921 | W | Saint Olaf (MN) | 7 | Macalester (MN) | 6 | Northfield, MN | |
| 1921 | L | Saint Olaf (MN) | 2 | Saint Thomas (MN) | 7 | ? | |
| 1921 | L | Saint Olaf (MN) | 3 | Carleton (MN) | 20 | ? | 20-2? |
| 1921 | W | Saint Olaf (MN) | 97 | Concordia-Moorhead (MN) | 0 | Northfield, MN | |
| 1921 | T | Saint Paul Academy (MN) | 0 | Phalen Luther Seminary (MN) | 0 | ? | |
| 1921 | L | Saint Paul Central HS (MN) | 7 | Minneapolis Central HS (MN) | 13 | ? | |
| 1921 | W | Saint Paul Central HS (MN) | 38 | Phalen Luther Seminary (MN) | 0 | ? | |
| 1921 | W | Saint Paul Humboldt HS (MN) | 13 | Phalen Luther Seminary (MN) | 2 | ? | |
| 1921 | L | Saint Paul Humboldt HS (MN) | 0 | Saint Cloud HS (MN) | 35 | ? | |
| 1921 | L | Saint Paul Humboldt HS (MN) | 0 | Stillwater HS (MN) | 13 | ? | |
| 1921 | T | Saint Paul Johnson HS (MN) | 6 | Phalen Luther Seminary (MN) | 6 | ? | |
| 1921 | W | Saint Paul's (VA) | 6 | Attucks AC | 0 | ? | |
| 1921 | L | Saint Paul's (VA) | 2 | Hampton (VA) | 26 | ? | |
| 1921 | W | Saint Paul's (VA) | 33 | Kittrell College (NC) | 0 | ? | |
| 1921 | W | Saint Paul's (VA) | 20 | North Carolina A&T | 6 | ? | |
| 1921 | W | Saint Paul's (VA) | 111 | North Carolina Central | 0 | ? | |
| 1921 | W | Saint Paul's (VA) | 7 | Saint Augustine's (NC) | 0 | ? | |
| 1921 | L | Saint Paul's (VA) | 7 | Virginia Union | 52 | Richmond, VA | |
| 1921 | W | Saint Paul's (VA) | 7 | Virginia-Lynchburg | 6 | ? | |
| 1921 | T | Saint Paul's School (NY) | 0 | Brooklyn Boys HS (NY) | 0 | ? | |
| 1921 | L | Saint Paul's School (NY) | 3 | Brooklyn Manual Training HS (NY) | 33 | ? | |
| 1921 | W | Saint Paul's School (NY) | 26 | Freeport HS (NY) | 0 | ? | |
| 1921 | L | Saint Paul's School (NY) | 0 | Hackley School (NY) | 7 | Garden City, NY | |
| 1921 | W | Saint Peter HS (MN) | 48 | Blue Earth HS (MN) | 0 | ? | |
| 1921 | L | Saint Peter HS (MN) | 0 | Mankato HS (MN) | 3 | ? | |
| 1921 | T | Saint Peter HS (MN) | 0 | New Prague HS (MN) | 0 | ? | |
| 1921 | W | Saint Peter HS (MN) | 67 | New Ulm HS (MN) | 0 | ? | |
| 1921 | W | Saint Peter HS (MN) | 34 | Redwood Falls HS (MN) | 0 | ? | |
| 1921 | W | Saint Peter HS (MN) | 13 | Sleepy Eye HS (MN) | 0 | ? | |
| 1921 | W | Saint Peter HS (MN) | 46 | Waseca HS (MN) | 0 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 31 | Bayonne HS (NJ) | 0 | ? | |
| 1921 | L | Saint Peter's Prep (NJ) | 0 | Brooklyn Prep School (NY) | 13 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 27 | Carlton Academy (NJ) | 0 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 20 | Clason Military Academy (NY) | 0 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 7 | Cliffside Park HS (NJ) | 3 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 13 | Jersey City Dickinson HS (NJ) | 7 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 12 | Jersey City Lincoln HS (NJ) | 0 | ? | |
| 1921 | L | Saint Peter's Prep (NJ) | 13 | Paterson HS (NJ) | 14 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 6 | Saint Benedict Prep School (NJ) | 3 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 36 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | W | Saint Peter's Prep (NJ) | 26 | Upsala (NJ) | 6 | ? | |
| 1921 | L | Saint Petersburg HS (FL) | 0 | Jacksonville Duval HS (FL) | 39 | ? | |
| 1921 | W | Saint Stanislaus College (MS) | 21 | Loyola (LA) | 0 | Bay Saint Louis, MS | |
| 1921 | W | Saint Stanislaus College (MS) | 49 | Southern Mississippi | 0 | Bay Saint Louis, MS | |
| 1921 | L | Saint Stephen's College (NY) | 0 | Buffalo (NY) | 54 | Buffalo, NY | |
| 1921 | L | Saint Stephen's College (NY) | 0 | Connecticut | 21 | Storrs, CT | |
| 1921 | T | Saint Stephen's College (NY) | 13 | New York Military Academy | 13 | ? | |
| 1921 | L | Saint Stephen's College (NY) | 0 | Saint Lawrence (NY) | 10 | Canton, NY | |
| 1921 | L | Saint Stephen's College JV (NY) | 0 | Poughkeepsie HS (NY) | 13 | ? | |
| 1921 | L | Saint Thomas (MN) | 7 | Carleton (MN) | 14 | ? | |
| 1921 | W | Saint Thomas (MN) | 42 | Gustavus Adolphus (MN) | 6 | Saint Peter, MN | |
| 1921 | L | Saint Thomas (MN) | 0 | Hamline (MN) | 17 | Saint Paul, MN | |
| 1921 | W | Saint Thomas (MN) | 7 | Saint Olaf (MN) | 2 | ? | |
| 1921 | W | Saint Thomas (MN) | 28 | Wisconsin-La Crosse | 13 | La Crosse, WI | |
| 1921 | W | Saint Thomas (MN) | 7 | Saint Mary's (MN) | 0 | Saint Paul, MN | |
| 1921 | L | Saint Thomas HS | 6 | Alexandria HS (MN) | 48 | ? | |
| 1921 | L | Saint Thomas HS | 0 | Minneapolis East HS (MN) | 34 | ? | |
| 1921 | W | Saint Viator (IL) | 67 | Crane JC (IL) | 0 | Bourbonnais, IL | |
| 1921 | L | Saint Viator (IL) | 7 | Lombard (IL) | 27 | Galesburg, IL | |
| 1921 | W | Saint Viator (IL) | 7 | North Central (IL) | 6 | Naperville, IL | |
| 1921 | W | Saint Viator (IL) | 19 | Northern Illinois | 10 | DeKalb, IL | |
| 1921 | T | Saint Viator (IL) | 0 | Valparaiso (IN) | 0 | Bourbonnais, IL | |
| 1921 | W | Saint Viator (IL) | 19 | DePaul (IL) | 0 | Chicago, IL | |
| 1921 | W | Saint Viator (IL) | 80 | Lincoln College (IL) | 0 | Bourbonnais, IL | |
| 1921 | W | Saint Viator (IL) | 86 | Shurtleff (IL) | 0 | Bourbonnais, IL | |
| 1921 | L | Saint Viator Academy | 7 | Loyola Academy (IL) | 14 | ? | |
| 1921 | L | Saint Vincent's Academy | 0 | Marvin College (MO) | 34 | ? | |
| 1921 | L | Saint Vincent's HS | 0 | Akron Central HS (OH) | 58 | ? | |
| 1921 | L | Saint Xavier Prep | 18 | Miami Military Institute (OH) | 20 | ? | |
| 1921 | L | Saint Xavier's Hall | 0 | Saint Joseph's (IN) | 29 | ? | |
| 1921 | W | Salem College (WV) | 7 | Broaddus College (WV) | 0 | ? | |
| 1921 | W | Salem College (WV) | 16 | Davis & Elkins (WV) | 0 | ? | |
| 1921 | W | Salem College (WV) | 42 | Fairmont St. (WV) | 7 | ? | |
| 1921 | L | Salem College (WV) | 0 | Marshall (WV) | 6 | ? | |
| 1921 | W | Salem College (WV) | 37 | Rio Grande (OH) | 0 | ? | |
| 1921 | W | Salem College (WV) | 7 | West Virginia Wesleyan | 0 | ? | |
| 1921 | W | Salem HS (MA) | 13 | Essex County Agriculture School (MA) | 0 | ? | |
| 1921 | L | Salem HS (MA) | 7 | Marblehead HS (MA) | 10 | ? | |
| 1921 | L | Salem HS (MA) | 0 | Peabody HS (MA) | 12 | ? | |
| 1921 | L | Salem HS (MA) | 0 | Saint John's Prep (MA) | 7 | ? | |
| 1921 | L | Salem HS (MA) | 0 | Woburn HS (MA) | 7 | ? | |
| 1921 | T | Salem HS (NJ) | 19 | Glassboro HS (NJ) | 19 | ? | |
| 1921 | W | Salem HS (NJ) | 21 | Haddon Heights HS (NJ) | 12 | ? | |
| 1921 | T | Salem HS (NJ) | 14 | Penns Grove HS (NJ) | 14 | ? | |
| 1921 | L | Salem HS (NJ) | 6 | Penns Grove HS (NJ) | 39 | ? | |
| 1921 | W | Salem HS (OH) | 14 | Alliance HS (OH) | 6 | ? | |
| 1921 | L | Salem HS (OH) | 7 | Fairmont East Side HS (WV) | 46 | ? | |
| 1921 | L | Salem HS (OH) | 6 | Warren HS (OH) | 7 | ? | |
| 1921 | L | Salem HS (OH) | 0 | Youngstown South HS (OH) | 7 | ? | |
| 1921 | T | Salem HS (VA) | 7 | Blacksburg HS (VA) | 7 | ? | |
| 1921 | L | Salem HS (VA) | 7 | Chatham Training School (VA) | 19 | ? | |
| 1921 | W | Salem HS (VA) | 41 | Christiansburg Institute (VA) | 0 | ? | |
| 1921 | W | Salem HS (VA) | 14 | Danville HS (VA) | 6 | ? | |
| 1921 | L | Salem HS (VA) | 0 | Lynchburg HS (VA) | 9 | ? | |
| 1921 | L | Salem HS (VA) | 7 | Randolph-Macon Academy (VA) | 13 | ? | |
| 1921 | L | Salem HS (VA) | 0 | Roanoke HS (VA) | 20 | ? | |
| 1921 | L | Salem HS (WV) | 0 | West Union HS (WV) | 48 | ? | |
| 1921 | L | Salem HS (WV) | 0 | West Union HS (WV) | 46 | ? | |
| 1921 | L | Salesianum HS (DE) | 7 | Chester HS (PA) | 25 | ? | |
| 1921 | W | Salesianum HS (DE) | 20 | Newark HS (DE) | 6 | ? | |
| 1921 | L | Salina HS (KS) | 0 | Kingman HS (KS) | 102 | ? | |
| 1921 | W | Salinas HS (CA) | 14 | Hollister HS (CA) | 7 | ? | |
| 1921 | W | Salinas HS (CA) | 12 | Pacific Grove HS (CA) | 0 | ? | |
| 1921 | L | Salinas HS (CA) | 6 | Palo Alto HS (CA) | 7 | ? | |
| 1921 | W | Salinas HS (CA) | 7 | Santa Cruz HS (CA) | 2 | ? | |
| 1921 | W | Salinas HS (CA) | 72 | Watsonville HS (CA) | 0 | ? | |
| 1921 | W | Salisbury HS (CT) | 69 | Pawling School (NY) | 0 | ? | |
| 1921 | W | Salisbury Prep (CT) | 26 | Torrington HS (CT) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 28 | Colorado Springs HS (CO) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 41 | Davis County HS (UT) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 26 | Granite HS (UT) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 50 | Idaho Falls HS (ID) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 58 | Jordan HS | 7 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 114 | Latter Day Saints HS (UT) | 7 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 30 | Logan HS (UT) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 55 | Park City HS (UT) | 7 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 56 | Payson HS (UT) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 30 | Salt Lake City West Side HS (UT) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 14 | Twin Falls HS (ID) | 0 | ? | |
| 1921 | W | Salt Lake City East Side HS (UT) | 20 | Westminster College (UT) | 7 | ? | |
| 1921 | L | Salt Lake City West Side HS (UT) | 0 | Salt Lake City East Side HS (UT) | 30 | ? | |
| 1921 | W | Sam Houston St. (TX) | 32 | Allen Academy (TX) | 0 | Huntsville, TX | |
| 1921 | W | Sam Houston St. (TX) | 69 | Ellington AFB (TX) | 0 | Huntsville, TX | |
| 1921 | T | Sam Houston St. (TX) | 6 | Lon Morris (TX) | 6 | Jacksonville, TX | |
| 1921 | T | Sam Houston St. (TX) | 7 | Texas A&M B Team | 7 | Huntsville, TX | |
| 1921 | W | Sam Houston St. (TX) | 7 | Texas A&M-Commerce | 0 | Commerce, TX | |
| 1921 | L | Sam Houston St. (TX) | 13 | Texas St. | 14 | Huntsville, TX | |
| 1921 | L | Samford (AL) | 14 | Alabama | 34 | Tuscaloosa, AL | |
| 1921 | L | Samford (AL) | 14 | Birmingham-Southern (AL) | 16 | Birmingham, AL | |
| 1921 | L | Samford (AL) | 0 | Florida | 34 | Montgomery, AL | |
| 1921 | W | Samford (AL) | 39 | Jacksonville St. (AL) | 7 | Birmingham, AL | |
| 1921 | L | Samford (AL) | 3 | Tennessee-Chattanooga | 26 | Gadsden, AL | |
| 1921 | L | Samford (AL) | 3 | Auburn (AL) | 34 | Birmingham, AL | |
| 1921 | W | Samford (AL) | 21 | Marion Military Institute (AL) | 0 | Montgomery, AL | |
| 1921 | W | Samford (AL) | 45 | Millsaps (MS) | 0 | Birmingham, AL | |
| 1921 | L | Samford (AL) | 0 | Spring Hill (AL) | 7 | Mobile, AL | |
| 1921 | L | San Bernardino American Legion (CA) | 0 | Sherman Indian School (CA) | 28 | ? | |
| 1921 | L | San Bernardino HS (CA) | 0 | Chaffee HS (CA) | 26 | ? | |
| 1921 | L | San Bernardino HS (CA) | 0 | Redlands (CA) | 63 | ? | |
| 1921 | W | San Diego Army & Navy (CA) | 12 | Loyola Marymount (CA) | 4 | ? | |
| 1921 | W | San Diego HS (CA) | 49 | Citrus Union HS (CA) | 0 | ? | |
| 1921 | W | San Diego HS (CA) | 48 | Los Angeles Manual Arts HS (CA) | 14 | ? | |
| 1921 | W | San Diego HS (CA) | 6 | Los Angeles Poly HS (CA) | 0 | ? | |
| 1921 | W | San Diego HS (CA) | 70 | Montabello | 0 | ? | |
| 1921 | W | San Diego HS (CA) | 40 | National City HS (CA) | 0 | ? | |
| 1921 | W | San Diego HS (CA) | 48 | Orange HS (CA) | 0 | ? | |
| 1921 | L | San Diego HS (CA) | 0 | Santa Ana HS (CA) | 14 | ? | |
| 1921 | L | San Diego HS (CA) | 3 | Santa Ana HS (CA) | 34 | ? | |
| 1921 | W | San Diego HS (CA) | 21 | Santa Monica HS (CA) | 0 | ? | |
| 1921 | W | San Diego HS (CA) | 35 | USS Charleston | 0 | ? | |
| 1921 | W | San Diego HS (CA) | 25 | USS Melville | 0 | ? | |
| 1921 | W | San Diego St. (CA) | 12 | Army-Navy Academy (CA) | 0 | San Diego, CA | College Field |
| 1921 | L | San Diego St. (CA) | 7 | North Island NAS (CA) | 12 | San Diego, CA | Navy "Sports" Field |
| 1921 | L | San Diego St. (CA) | 7 | Riverside JC (CA) | 19 | Riverside, CA | Riverside Poly HS Field |
| 1921 | L | San Diego St. (CA) | 0 | Santa Ana College (CA) | 26 | Santa Ana, CA | Santa Ana HS Field |
| 1921 | L | San Diego St. (CA) | 0 | USS Birmingham | 14 | San Diego, CA | College Field |
| 1921 | W | San Diego St. (CA) | 14 | USS Birmingham | 6 | San Diego, CA | College Field |
| 1921 | W | San Diego St. (CA) | 6 | Army-Navy Academy (CA) | 0 | Pacific Beach, CA | Academy Field, Pacific Beach |
| 1921 | L | San Diego St. (CA) | 0 | Fullerton College (CA) | 20 | San Diego, CA | Balboa Stadium |
| 1921 | L | San Diego St. (CA) | 0 | Reserve Destroyers (CA) | 3 | San Diego, CA | College Field |
| 1921 | W | San Diego St. (CA) | 14 | Chaffey CC (CA) | 0 | San Diego, CA | Balboa Stadium |
| 1921 | L | San Francisco American Legion (CA) | 0 | Santa Clara (CA) | 7 | ? | |
| 1921 | L | San Francisco HS of Commerce (CA) | 0 | Alameda HS (CA) | 47 | ? | |
| 1921 | L | San Francisco HS of Commerce (CA) | 0 | California Freshmen | 97 | ? | |
| 1921 | W | San Francisco HS of Commerce (CA) | 33 | Cogswell Polytechnical College (CA) | 0 | ? | |
| 1921 | W | San Francisco HS of Commerce (CA) | 14 | Galileo HS | 3 | ? | |
| 1921 | W | San Francisco HS of Commerce (CA) | 19 | Potter School (CA) | 0 | ? | |
| 1921 | W | San Francisco HS of Commerce (CA) | 48 | Sacred Heart College (CA) | 14 | ? | |
| 1921 | L | San Francisco HS of Commerce (CA) | 0 | San Francisco Lick Wilmerling HS (CA) | 20 | ? | |
| 1921 | L | San Francisco HS of Commerce (CA) | 0 | San Francisco Lowell HS (CA) | 61 | ? | |
| 1921 | W | San Francisco HS of Commerce (CA) | 27 | San Francisco Mission HS (CA) | 0 | ? | |
| 1921 | L | San Francisco HS of Commerce (CA) | 0 | San Francisco Polytechnic HS (CA) | 39 | ? | |
| 1921 | W | San Francisco HS of Commerce (CA) | 41 | San Francisco South HS (CA) | 6 | ? | |
| 1921 | W | San Francisco HS of Commerce (CA) | 7 | San Rafael HS (CA) | 6 | ? | |
| 1921 | L | San Francisco HS of Commerce (CA) | 6 | San Rafael HS (CA) | 7 | ? | |
| 1921 | W | San Francisco Lick Wilmerling HS (CA) | 28 | Cogswell Polytechnical College (CA) | 0 | ? | |
| 1921 | W | San Francisco Lick Wilmerling HS (CA) | 13 | John C. Fremont HS (CA) | 6 | ? | |
| 1921 | L | San Francisco Lick Wilmerling HS (CA) | 7 | Palo Alto HS (CA) | 14 | ? | |
| 1921 | W | San Francisco Lick Wilmerling HS (CA) | 33 | Sacred Heart College (CA) | 0 | ? | |
| 1921 | W | San Francisco Lick Wilmerling HS (CA) | 20 | San Francisco HS of Commerce (CA) | 0 | ? | |
| 1921 | T | San Francisco Lick Wilmerling HS (CA) | 7 | San Francisco Lowell HS (CA) | 7 | ? | |
| 1921 | W | San Francisco Lick Wilmerling HS (CA) | 35 | San Francisco Mission HS (CA) | 6 | ? | |
| 1921 | W | San Francisco Lick Wilmerling HS (CA) | 7 | San Francisco Polytechnic HS (CA) | 0 | ? | |
| 1921 | L | San Francisco Lick Wilmerling HS (CA) | 0 | San Francisco University School (CA) | 7 | ? | |
| 1921 | W | San Francisco Lick Wilmerling HS (CA) | 13 | Santa Cruz HS (CA) | 7 | ? | |
| 1921 | L | San Francisco Lick Wilmerling HS (CA) | 7 | Tamalpais HS (CA) | 14 | ? | |
| 1921 | L | San Francisco Lowell Boys HS (CA) | 0 | Berkeley HS (CA) | 20 | ? | |
| 1921 | W | San Francisco Lowell HS (CA) | 61 | San Francisco HS of Commerce (CA) | 0 | ? | |
| 1921 | T | San Francisco Lowell HS (CA) | 7 | San Francisco Lick Wilmerling HS (CA) | 7 | ? | |
| 1921 | W | San Francisco Lowell HS (CA) | 14 | Santa Rosa HS (CA) | 6 | ? | |
| 1921 | L | San Francisco Mission HS (CA) | 6 | Potter School (CA) | 12 | ? | |
| 1921 | L | San Francisco Mission HS (CA) | 0 | San Francisco HS of Commerce (CA) | 27 | ? | |
| 1921 | L | San Francisco Mission HS (CA) | 6 | San Francisco Lick Wilmerling HS (CA) | 35 | ? | |
| 1921 | L | San Francisco Mission HS (CA) | 0 | San Rafael HS (CA) | 21 | ? | |
| 1921 | T | San Francisco Mission HS (CA) | 0 | Tamalpais HS (CA) | 0 | ? | |
| 1921 | T | San Francisco Olympic Club (CA) | 0 | 9th Army Corps (WA) | 0 | San Francisco, CA | Score unknown |
| 1921 | L | San Francisco Olympic Club (CA) | 7 | Saint Mary's (CA) | 20 | ? | |
| 1921 | L | San Francisco Olympic Club (CA) | 0 | Stanford (CA) | 7 | Stanford, CA | |
| 1921 | L | San Francisco Olympic Club (CA) | 0 | California | 14 | Berkeley, CA | |
| 1921 | W | San Francisco Polytechnic HS (CA) | 39 | San Francisco HS of Commerce (CA) | 0 | ? | |
| 1921 | L | San Francisco Polytechnic HS (CA) | 0 | San Francisco Lick Wilmerling HS (CA) | 7 | ? | |
| 1921 | L | San Francisco University School (CA) | 0 | Centerville HS (CA) | 12 | ? | |
| 1921 | W | San Francisco University School (CA) | 7 | Galileo HS | 0 | ? | |
| 1921 | L | San Francisco University School (CA) | 0 | Richmond HS (CA) | 12 | ? | |
| 1921 | W | San Francisco University School (CA) | 24 | Sacred Heart College (CA) | 12 | ? | |
| 1921 | W | San Francisco University School (CA) | 7 | San Francisco Lick Wilmerling HS (CA) | 0 | ? | |
| 1921 | W | San Francisco University School (CA) | 7 | Tamalpais Military Academy (CA) | 0 | ? | |
| 1921 | W | San Jose HS (CA) | 35 | Mountain View HS (CA) | 0 | ? | |
| 1921 | L | San Jose HS (CA) | 8 | Palo Alto HS (CA) | 12 | ? | |
| 1921 | W | San Jose HS (CA) | 14 | Redwood City HS (CA) | 0 | ? | |
| 1921 | W | San Jose HS (CA) | 20 | San Jose St. (CA) | 7 | ? | |
| 1921 | W | San Jose HS (CA) | 7 | San Jose St. (CA) | 0 | ? | |
| 1921 | W | San Jose HS (CA) | 36 | San Mateo HS (CA) | 0 | ? | |
| 1921 | L | San Jose HS (CA) | 2 | Santa Cruz HS (CA) | 19 | ? | |
| 1921 | W | San Jose HS (CA) | 14 | William Warren Military School (CA) | 0 | ? | |
| 1921 | W | San Jose St. (CA) | 14 | Fresno St. (CA) | 2 | Fresno, CA | |
| 1921 | L | San Jose St. (CA) | 14 | Hollister JC (CA) | 30 | ? | |
| 1921 | L | San Jose St. (CA) | 0 | Pacific (CA) | 34 | Stockton, CA | |
| 1921 | L | San Jose St. (CA) | 7 | San Jose HS (CA) | 20 | ? | |
| 1921 | L | San Jose St. (CA) | 0 | San Jose HS (CA) | 7 | ? | |
| 1921 | L | San Jose St. (CA) | 0 | Santa Clara University HS (CA) | 48 | ? | |
| 1921 | W | San Marcos Baptist (TX) | 14 | Allen Academy (TX) | 6 | ? | |
| 1921 | W | San Marcos Baptist (TX) | 24 | Baylor Freshmen (TX) | 9 | ? | |
| 1921 | L | San Marcos Baptist (TX) | 0 | Saint Edward's (TX) | 27 | ? | |
| 1921 | W | San Marcos Baptist (TX) | 41 | Saint Mary's (TX) | 0 | ? | |
| 1921 | L | San Marcos Baptist (TX) | 0 | Texas Freshmen | 72 | ? | |
| 1921 | L | San Marcos Baptist (TX) | 3 | Texas St. | 62 | ? | |
| 1921 | W | San Marcos Baptist (TX) | 62 | West Texas Military Academy | 7 | ? | |
| 1921 | W | San Pedro Submarine Base (CA) | 14 | Occidental (CA) | 7 | ? | |
| 1921 | L | San Pedro Submarine Base (CA) | 0 | Southern California | 28 | ? | |
| 1921 | L | San Pedro Submarine Base (CA) | 0 | Southern California | 34 | Los Angeles, CA | |
| 1921 | L | Sanborn Seminary (NH) | 0 | Phillips Exeter Academy (NH) | 41 | ? | |
| 1921 | L | Sanborn Seminary (NH) | 0 | Phillips Exeter Academy (NH) | 12 | ? | |
| 1921 | W | Sand Springs HS (OK) | 35 | Collinsville HS (OK) | 6 | ? | |
| 1921 | W | Sandusky HS (OH) | 31 | Bellevue HS (OH) | 0 | ? | |
| 1921 | W | Sandusky HS (OH) | 28 | Bucyrus HS (OH) | 0 | ? | |
| 1921 | T | Sandusky HS (OH) | 0 | Cleveland Lincoln HS (OH) | 0 | ? | |
| 1921 | W | Sandusky HS (OH) | 16 | Elyria HS (OH) | 0 | ? | |
| 1921 | L | Sandusky HS (OH) | 7 | Findlay HS (OH) | 14 | ? | |
| 1921 | W | Sandusky HS (OH) | 6 | Lorain HS (OH) | 0 | ? | |
| 1921 | W | Sandusky HS (OH) | 16 | Mansfield HS (OH) | 6 | ? | |
| 1921 | W | Sandusky HS (OH) | 7 | Norwalk HS (OH) | 0 | ? | |
| 1921 | L | Sandusky HS (OH) | 0 | Oberlin HS (OH) | 7 | ? | |
| 1921 | W | Sandusky HS (OH) | 13 | Tiffin HS (OH) | 7 | ? | |
| 1921 | L | Sanford HS (ME) | 0 | King School (CT) | 38 | ? | |
| 1921 | W | Sanford HS (NC) | 20 | Smithfield HS (NC) | 0 | ? | |
| 1921 | L | Sanford Legion | 0 | Rollins (FL) | 33 | ? | |
| 1921 | L | Sanger HS (CA) | 0 | Dinuba HS (CA) | 60 | ? | |
| 1921 | L | Sanger HS (CA) | 0 | Fresno HS (CA) | 47 | ? | |
| 1921 | L | Sanger HS (CA) | 0 | Selma HS (CA) | 61 | ? | |
| 1921 | W | Santa Ana College (CA) | 26 | San Diego St. (CA) | 0 | Santa Ana, CA | Santa Ana HS Field |
| 1921 | W | Santa Ana HS (CA) | 55 | Anaheim HS (CA) | 0 | ? | |
| 1921 | W | Santa Ana HS (CA) | 21 | Chaffee HS (CA) | 7 | ? | |
| 1921 | W | Santa Ana HS (CA) | 7 | Fullerton HS (CA) | 0 | ? | |
| 1921 | W | Santa Ana HS (CA) | 17 | Harvard Military School (CA) | 0 | ? | |
| 1921 | L | Santa Ana HS (CA) | 7 | Kern County HS (CA) | 35 | ? | |
| 1921 | L | Santa Ana HS (CA) | 0 | Los Angeles HS (CA) | 7 | ? | |
| 1921 | W | Santa Ana HS (CA) | 91 | Orange HS (CA) | 0 | ? | |
| 1921 | W | Santa Ana HS (CA) | 34 | Outlaws | 0 | ? | |
| 1921 | W | Santa Ana HS (CA) | 3 | Pasadena HS (CA) | 0 | ? | |
| 1921 | W | Santa Ana HS (CA) | 14 | San Diego HS (CA) | 0 | ? | |
| 1921 | W | Santa Ana HS (CA) | 34 | San Diego HS (CA) | 3 | ? | |
| 1921 | W | Santa Ana HS (CA) | 13 | Santa Monica HS (CA) | 0 | ? | |
| 1921 | W | Santa Ana HS (CA) | 55 | Van Nuys HS (CA) | 7 | ? | |
| 1921 | W | Santa Ana HS (CA) | 66 | Whittier HS (CA) | 0 | ? | |
| 1921 | L | Santa Barbara City JC (CA) | 0 | Cal Poly-San Luis Obispo | 42 | San Luis Obispo, CA | |
| 1921 | W | Santa Barbara HS (CA) | 48 | Alhambra HS (CA) | 7 | ? | |
| 1921 | W | Santa Barbara HS (CA) | 14 | California-Santa Barbara | 0 | ? | |
| 1921 | W | Santa Barbara HS (CA) | 28 | Franklin HS | 0 | ? | |
| 1921 | L | Santa Barbara HS (CA) | 3 | Harvard Military School (CA) | 7 | ? | |
| 1921 | W | Santa Barbara HS (CA) | 21 | Huntington Park HS (CA) | 7 | ? | |
| 1921 | W | Santa Barbara HS (CA) | 7 | Los Angeles Hollywood HS (CA) | 0 | ? | |
| 1921 | L | Santa Barbara HS (CA) | 0 | Los Angeles Jefferson HS (CA) | 13 | ? | |
| 1921 | W | Santa Barbara HS (CA) | 37 | Santa Maria HS (CA) | 0 | ? | |
| 1921 | L | Santa Barbara HS (CA) | 21 | Venice HS (CA) | 27 | ? | |
| 1921 | W | Santa Clara (CA) | 41 | Agnetian AC (CA) | 0 | Santa Clara, CA | |
| 1921 | W | Santa Clara (CA) | 73 | Antioch American Legion (CA) | 0 | ? | |
| 1921 | W | Santa Clara (CA) | 49 | California-Davis | 0 | Santa Clara, CA | |
| 1921 | W | Santa Clara (CA) | 49 | Fresno American Legion (CA) | 0 | ? | |
| 1921 | W | Santa Clara (CA) | 14 | Mare Island Marines (CA) | 0 | Santa Clara, CA | |
| 1921 | W | Santa Clara (CA) | 7 | San Francisco American Legion (CA) | 0 | ? | |
| 1921 | L | Santa Clara HS (CA) | 0 | Mountain View HS (CA) | 24 | ? | |
| 1921 | L | Santa Clara HS (CA) | 0 | Palo Alto HS (CA) | 42 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 32 | Alameda HS (CA) | 0 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 35 | Bates University School (CA) | 0 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 72 | Sacred Heart College (CA) | 0 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 48 | San Jose St. (CA) | 0 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 56 | Santa Rosa JC (CA) | 0 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 39 | Tamalpais Military Academy (CA) | 0 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 54 | Watsonville HS (CA) | 0 | ? | |
| 1921 | W | Santa Clara University HS (CA) | 19 | William Warren Military School (CA) | 16 | ? | |
| 1921 | W | Santa Cruz HS (CA) | 21 | Hollister HS (CA) | 9 | ? | |
| 1921 | W | Santa Cruz HS (CA) | 39 | Pacific Grove HS (CA) | 6 | ? | |
| 1921 | L | Santa Cruz HS (CA) | 2 | Salinas HS (CA) | 7 | ? | |
| 1921 | L | Santa Cruz HS (CA) | 7 | San Francisco Lick Wilmerling HS (CA) | 13 | ? | |
| 1921 | W | Santa Cruz HS (CA) | 19 | San Jose HS (CA) | 2 | ? | |
| 1921 | W | Santa Cruz HS (CA) | 13 | San Mateo HS (CA) | 0 | ? | |
| 1921 | W | Santa Cruz HS (CA) | 42 | Watsonville HS (CA) | 6 | ? | |
| 1921 | L | Santa Fe Shops | 7 | Redlands (CA) | 47 | ? | |
| 1921 | L | Santa Maria HS (CA) | 7 | Cal Poly-San Luis Obispo | 14 | San Luis Obispo, CA | |
| 1921 | L | Santa Maria HS (CA) | 0 | Santa Barbara HS (CA) | 37 | ? | |
| 1921 | T | Santa Maria HS (CA) | 7 | Cal Poly-San Luis Obispo | 7 | San Luis Obispo, CA | |
| 1921 | L | Santa Maria Legion | 0 | Saint Mary's (CA) | 68 | ? | |
| 1921 | W | Santa Monica All-Stars (CA) | 41 | Loyola Marymount (CA) | 0 | ? | |
| 1921 | W | Santa Monica HS (CA) | 14 | Fullerton HS (CA) | 13 | ? | |
| 1921 | W | Santa Monica HS (CA) | 42 | Los Angeles Jefferson HS (CA) | 0 | ? | |
| 1921 | L | Santa Monica HS (CA) | 3 | Loyola Marymount (CA) | 9 | Santa Monica, CA | |
| 1921 | L | Santa Monica HS (CA) | 0 | San Diego HS (CA) | 21 | ? | |
| 1921 | W | Santa Monica HS (CA) | 42 | San Pedro HS (CA) | 0 | ? | |
| 1921 | L | Santa Monica HS (CA) | 0 | Santa Ana HS (CA) | 13 | ? | |
| 1921 | W | Santa Monica HS (CA) | 30 | Whittier HS (CA) | 0 | ? | |
| 1921 | L | Santa Rosa HS (CA) | 0 | Berkeley HS (CA) | 83 | ? | |
| 1921 | W | Santa Rosa HS (CA) | 1 | Calistoga HS (CA) | 0 | ? | Calistoga HS Forfeits |
| 1921 | W | Santa Rosa HS (CA) | 54 | Eureka HS (CA) | 10 | ? | |
| 1921 | T | Santa Rosa HS (CA) | 7 | Napa HS (CA) | 7 | ? | |
| 1921 | W | Santa Rosa HS (CA) | 33 | Petaluma HS (CA) | 0 | ? | |
| 1921 | W | Santa Rosa HS (CA) | 35 | Petaluma HS (CA) | 6 | ? | |
| 1921 | L | Santa Rosa HS (CA) | 13 | Richmond HS (CA) | 14 | ? | |
| 1921 | L | Santa Rosa HS (CA) | 6 | San Francisco Lowell HS (CA) | 14 | ? | |
| 1921 | T | Santa Rosa HS (CA) | 7 | Santa Rosa JC (CA) | 7 | ? | |
| 1921 | W | Santa Rosa HS (CA) | 49 | Tamalpais HS (CA) | 0 | ? | |
| 1921 | L | Santa Rosa HS (CA) | 7 | Tamalpais Military Academy (CA) | 35 | ? | |
| 1921 | W | Santa Rosa HS (CA) | 26 | Ukiah HS (CA) | 13 | ? | |
| 1921 | L | Santa Rosa JC (CA) | 0 | Santa Clara University HS (CA) | 56 | ? | |
| 1921 | T | Santa Rosa JC (CA) | 7 | Santa Rosa HS (CA) | 7 | ? | |
| 1921 | W | Sapulpa HS (OK) | 21 | Ardmore HS (OK) | 14 | ? | |
| 1921 | W | Sapulpa HS (OK) | 14 | Bristow HS (OK) | 0 | ? | |
| 1921 | W | Sapulpa HS (OK) | 14 | Enid HS (OK) | 0 | ? | |
| 1921 | W | Sapulpa HS (OK) | 63 | Guthrie HS (OK) | 0 | ? | |
| 1921 | W | Sapulpa HS (OK) | 54 | Kansas City Manual HS (MO) | 0 | ? | |
| 1921 | W | Sapulpa HS (OK) | 49 | Lawton HS (OK) | 0 | ? | |
| 1921 | W | Sapulpa HS (OK) | 10 | Marion HS (KS) | 0 | ? | |
| 1921 | W | Sapulpa HS (OK) | 73 | Mounds Legion | 0 | ? | |
| 1921 | W | Sapulpa HS (OK) | 37 | Oklahoma City HS (OK) | 10 | ? | |
| 1921 | W | Sapulpa HS (OK) | 40 | Okmulgee HS (OK) | 6 | ? | |
| 1921 | W | Sapulpa HS (OK) | 33 | Pryor HS (OK) | 7 | ? | |
| 1921 | W | Sapulpa HS (OK) | 33 | Tulsa Central HS (OK) | 0 | ? | |
| 1921 | L | Sapulpa HS (OK) | 0 | Tulsa JV (OK) | 3 | ? | Tulsa JV in question |
| 1921 | W | Sapulpa HS (OK) | 21 | Warner HS (OK) | 9 | ? | |
| 1921 | W | Saratoga Springs HS (NY) | 38 | Cambridge HS (NY) | 0 | ? | |
| 1921 | L | Saratoga Springs HS (NY) | 10 | Glens Falls HS (NY) | 21 | ? | |
| 1921 | L | Saratoga Springs HS (NY) | 6 | Granville HS (NY) | 14 | ? | |
| 1921 | W | Saratoga Springs HS (NY) | 55 | Hudson Falls HS (NY) | 0 | ? | |
| 1921 | W | Saratoga Springs HS (NY) | 7 | Kingston HS (NY) | 0 | ? | |
| 1921 | W | Saratoga Springs HS (NY) | 7 | Troy HS (NY) | 0 | ? | |
| 1921 | W | Saratoga Springs HS (NY) | 19 | Union Freshmen (NY) | 7 | ? | |
| 1921 | W | Saratoga Springs HS (NY) | 36 | Whitehall HS (NY) | 0 | ? | |
| 1921 | L | Saugus HS (MA) | 6 | Brighton HS (MA) | 20 | ? | |
| 1921 | L | Saugus HS (MA) | 6 | Malden HS (MA) | 14 | ? | |
| 1921 | T | Saugus HS (MA) | 0 | Melrose HS (MA) | 0 | ? | |
| 1921 | W | Savannah St. (GA) | 19 | Haines Institute (GA) | 6 | ? | |
| 1921 | T | Sayre HS (PA) | 7 | Athens HS (PA) | 7 | ? | |
| 1921 | W | Sayre HS (PA) | 7 | Athens HS (PA) | 0 | ? | |
| 1921 | W | Sayre HS (PA) | 14 | Cook Academy (NY) | 6 | ? | |
| 1921 | L | Sayre Mechanical School (PA) | 0 | Mansfield (PA) | 85 | Mansfield, PA | |
| 1921 | W | Scarborough HS (NY) | 40 | Barnard School (NY) | 14 | ? | |
| 1921 | L | Scarsdale HS (NY) | 7 | Bronxville HS (NY) | 19 | ? | |
| 1921 | T | Schenley HS (PA) | 7 | Pittsburgh Allegheny HS (PA) | 7 | ? | |
| 1921 | W | Schenley HS (PA) | 18 | South Hills HS (PA) | 0 | ? | |
| 1921 | L | Schenley HS (PA) | 0 | Westinghouse HS (PA) | 20 | ? | |
| 1921 | L | Schuylkill College (PA) | 6 | Allentown Prep School (PA) | 26 | ? | |
| 1921 | L | Schuylkill College (PA) | 0 | Franklin & Marshall Academy (PA) | 21 | ? | |
| 1921 | W | Schuylkill College (PA) | 21 | Harrisburg Academy (PA) | 7 | ? | |
| 1921 | W | Schuylkill College (PA) | 20 | West Chester (PA) | 0 | West Chester, PA | |
| 1921 | L | Scotland School (PA) | 0 | Shippensburg (PA) | 1 | Shippensburg, PA | Scotland School Forfeits |
| 1921 | L | Scottsbluff HS (NE) | 14 | Alliance HS (NE) | 23 | ? | |
| 1921 | W | Scottsbluff HS (NE) | 35 | Sterling HS (CO) | 0 | ? | |
| 1921 | L | Scranton (PA) | 0 | East Stroudsburg (PA) | 14 | ? | |
| 1921 | L | Scranton (PA) | 0 | Endicott Union HS (NY) | 48 | ? | |
| 1921 | W | Scranton (PA) | 21 | Wilkes-Barre HS (PA) | 7 | ? | |
| 1921 | W | Scranton (PA) | 6 | Bloomsburg (PA) | 0 | Scranton, PA | |
| 1921 | L | Scranton Central HS (PA) | 2 | Easton HS (PA) | 27 | ? | |
| 1921 | L | Scranton Tech HS (PA) | 0 | Harrisburg Tech HS (PA) | 49 | ? | |
| 1921 | W | Scranton Tech HS (PA) | 32 | Wilkes-Barre HS (PA) | 0 | ? | |
| 1921 | T | Seattle Ballard HS (WA) | 0 | Seattle Broadway HS (WA) | 0 | ? | |
| 1921 | T | Seattle Ballard HS (WA) | 0 | Seattle Franklin HS (WA) | 0 | ? | |
| 1921 | T | Seattle Ballard HS (WA) | 0 | Seattle Lincoln HS (WA) | 0 | ? | |
| 1921 | L | Seattle Ballard HS (WA) | 3 | Seattle Queen Anne HS (WA) | 10 | ? | |
| 1921 | W | Seattle Ballard HS (WA) | 13 | West Seattle HS (WA) | 0 | ? | |
| 1921 | T | Seattle Broadway HS (WA) | 0 | Seattle Ballard HS (WA) | 0 | ? | |
| 1921 | L | Seattle Broadway HS (WA) | 0 | Seattle Franklin HS (WA) | 14 | ? | |
| 1921 | W | Seattle Broadway HS (WA) | 7 | Seattle Lincoln HS (WA) | 0 | ? | |
| 1921 | L | Seattle Broadway HS (WA) | 0 | Seattle Queen Anne HS (WA) | 14 | ? | |
| 1921 | L | Seattle Broadway HS (WA) | 0 | West Seattle HS (WA) | 14 | ? | |
| 1921 | T | Seattle Franklin HS (WA) | 0 | Seattle Ballard HS (WA) | 0 | ? | |
| 1921 | W | Seattle Franklin HS (WA) | 14 | Seattle Broadway HS (WA) | 0 | ? | |
| 1921 | W | Seattle Franklin HS (WA) | 20 | Seattle Lincoln HS (WA) | 0 | ? | |
| 1921 | W | Seattle Franklin HS (WA) | 7 | Seattle Queen Anne HS (WA) | 0 | ? | |
| 1921 | W | Seattle Franklin HS (WA) | 16 | West Seattle HS (WA) | 0 | ? | |
| 1921 | T | Seattle Lincoln HS (WA) | 0 | Seattle Ballard HS (WA) | 0 | ? | |
| 1921 | L | Seattle Lincoln HS (WA) | 0 | Seattle Broadway HS (WA) | 7 | ? | |
| 1921 | L | Seattle Lincoln HS (WA) | 0 | Seattle Franklin HS (WA) | 20 | ? | |
| 1921 | W | Seattle Lincoln HS (WA) | 21 | Seattle Queen Anne HS (WA) | 0 | ? | |
| 1921 | W | Seattle Queen Anne HS (WA) | 10 | Seattle Ballard HS (WA) | 3 | ? | |
| 1921 | W | Seattle Queen Anne HS (WA) | 14 | Seattle Broadway HS (WA) | 0 | ? | |
| 1921 | L | Seattle Queen Anne HS (WA) | 0 | Seattle Franklin HS (WA) | 7 | ? | |
| 1921 | L | Seattle Queen Anne HS (WA) | 0 | Seattle Lincoln HS (WA) | 21 | ? | |
| 1921 | W | Seattle Queen Anne HS (WA) | 13 | West Seattle HS (WA) | 6 | ? | |
| 1921 | L | Sedalia HS (MO) | 0 | Kemper Military School (MO) | 89 | ? | |
| 1921 | L | Sedro-Woolley HS (WA) | 0 | Western Washington | 14 | Ellensburg, WA | |
| 1921 | L | Seguin HS (TX) | 0 | Texas Lutheran | 47 | ? | |
| 1921 | L | Sellersville HS (PA) | 0 | Quakertown HS (PA) | 21 | ? | |
| 1921 | W | Selma HS (CA) | 69 | Fowler HS (CA) | 0 | ? | |
| 1921 | L | Selma HS (CA) | 0 | Fresno HS (CA) | 7 | ? | |
| 1921 | W | Selma HS (CA) | 35 | Hanford HS (CA) | 13 | ? | |
| 1921 | W | Selma HS (CA) | 75 | Madera HS (CA) | 0 | ? | |
| 1921 | W | Selma HS (CA) | 21 | Reedley College (CA) | 7 | ? | |
| 1921 | W | Selma HS (CA) | 61 | Sanger HS (CA) | 0 | ? | |
| 1921 | L | Selma HS (CA) | 0 | Stanford Freshmen (CA) | 23 | ? | |
| 1921 | W | Selma HS (CA) | 27 | Stockton HS (CA) | 0 | ? | |
| 1921 | W | Selma HS (CA) | 12 | Tulare HS (CA) | 0 | ? | |
| 1921 | L | Senatobia Agriculture HS (MS) | 7 | Clarksdale HS (MS) | 51 | ? | |
| 1921 | L | Sequoia HS | 7 | Palo Alto HS (CA) | 38 | ? | |
| 1921 | T | Sesser Athletics (IL) | 0 | Southern Illinois | 0 | Carbondale, IL | |
| 1921 | W | Seton Hall Prep School (NJ) | 24 | Carlton Academy (NJ) | 0 | ? | |
| 1921 | L | Seton Hall Prep School (NJ) | 0 | Orange HS (NJ) | 34 | ? | |
| 1921 | W | Severn School (MD) | 21 | Annapolis HS (MD) | 0 | ? | |
| 1921 | W | Severn School (MD) | 14 | Army & Navy Prep School (DC) | 7 | ? | |
| 1921 | L | Severn School (MD) | 0 | Baltimore City College (MD) | 7 | ? | |
| 1921 | W | Severn School (MD) | 20 | Calvert Hall | 0 | ? | |
| 1921 | W | Severn School (MD) | 14 | Charlotte Hall Military Academy (MD) | 0 | ? | |
| 1921 | W | Severn School (MD) | 27 | Johns Hopkins Freshmen (MD) | 0 | ? | |
| 1921 | W | Severn School (MD) | 14 | Loyola HS (MD) | 0 | ? | |
| 1921 | W | Severn School (MD) | 14 | Mount Saint Joseph's College (MD) | 0 | ? | |
| 1921 | W | Sewanee (TN) | 17 | Alabama | 0 | Birmingham, AL | |
| 1921 | W | Sewanee (TN) | 6 | Kentucky | 0 | Louisville, KY | |
| 1921 | W | Sewanee (TN) | 21 | Oglethorpe (GA) | 0 | Sewanee, TN | |
| 1921 | L | Sewanee (TN) | 0 | Vanderbilt (TN) | 9 | Nashville, TN | |
| 1921 | W | Sewanee (TN) | 28 | Cumberland (TN) | 0 | Sewanee, TN | |
| 1921 | W | Sewanee (TN) | 47 | Tennessee-Chattanooga | 0 | Chattanooga, TN | |
| 1921 | W | Sewanee (TN) | 102 | Bryson (TN) | 0 | Sewanee, TN | |
| 1921 | L | Sewanee (TN) | 0 | Tennessee | 21 | Knoxville, TN | |
| 1921 | L | Sewanee JV (TN) | 0 | Middle Tennessee St. | 7 | Murfreesboro, TN | |
| 1921 | L | Sewanee Military Academy (TN) | 6 | Tennessee Military Institute | 27 | ? | |
| 1921 | T | Sewickley HS (PA) | 0 | Ambridge HS (PA) | 0 | ? | |
| 1921 | L | Sewickley HS (PA) | 0 | Avalon HS (PA) | 7 | ? | |
| 1921 | W | Sewickley HS (PA) | 3 | Beaver Falls HS (PA) | 0 | ? | |
| 1921 | W | Sewickley HS (PA) | 14 | Beaver HS (PA) | 0 | ? | |
| 1921 | W | Sewickley HS (PA) | 7 | Ben Avon HS (PA) | 0 | ? | |
| 1921 | W | Sewickley HS (PA) | 41 | Coraopolis HS (PA) | 0 | ? | |
| 1921 | W | Sewickley HS (PA) | 7 | Grafton HS | 6 | ? | |
| 1921 | T | Sewickley HS (PA) | 0 | Monaca HS (PA) | 0 | ? | |
| 1921 | W | Shady Side Academy (PA) | 35 | Bellevue HS (PA) | 0 | ? | |
| 1921 | W | Shady Side Academy (PA) | 8 | Linsly Military Institute (WV) | 0 | ? | |
| 1921 | W | Shady Side Academy (PA) | 27 | Nichols School (NY) | 0 | ? | |
| 1921 | W | Shady Side Academy (PA) | 55 | Pittsburgh Academy (PA) | 0 | ? | |
| 1921 | W | Shady Side Academy (PA) | 95 | Sharpsburg HS (PA) | 0 | ? | |
| 1921 | W | Shady Side Academy (PA) | 41 | Swissvale HS (PA) | 3 | ? | |
| 1921 | L | Shady Side Academy (PA) | 0 | Wilkinsburg HS (PA) | 7 | ? | |
| 1921 | T | Shadyside HS (OH) | 0 | Richland District HS (WV) | 0 | ? | |
| 1921 | W | Shadyside HS (OH) | 14 | Sistersville HS (WV) | 2 | ? | |
| 1921 | L | Shakopee HS (MN) | 0 | New Prague HS (MN) | 26 | ? | |
| 1921 | L | Shamokin HS (PA) | 0 | Minersville HS (PA) | 24 | ? | |
| 1921 | L | Shamokin HS (PA) | 0 | Mount Carmel HS (PA) | 71 | ? | |
| 1921 | L | Shamokin HS (PA) | 0 | Williamsport HS (PA) | 56 | ? | |
| 1921 | W | Sharon HS (PA) | 7 | New Castle HS (PA) | 0 | ? | |
| 1921 | W | Sharon HS (PA) | 14 | Warren HS (OH) | 0 | ? | |
| 1921 | L | Sharpsburg HS (PA) | 7 | Ben Avon HS (PA) | 41 | ? | |
| 1921 | L | Sharpsburg HS (PA) | 0 | Shady Side Academy (PA) | 95 | ? | |
| 1921 | W | Shattuck School (MN) | 3 | Dunwoody College of Tech. (MN) | 0 | ? | |
| 1921 | W | Shattuck School (MN) | 14 | Owatonna HS (MN) | 13 | ? | |
| 1921 | W | Shattuck School (MN) | 16 | Winona St. (MN) | 0 | ? | |
| 1921 | L | Shattuck School (MN) | 0 | Wisconsin-River Falls | 7 | ? | |
| 1921 | L | Shaw (NC) | 6 | Hampton (VA) | 7 | ? | |
| 1921 | L | Shaw (NC) | 0 | Howard (DC) | 24 | ? | |
| 1921 | L | Shawnee HS (OK) | 0 | Oklahoma City HS (OK) | 17 | ? | |
| 1921 | W | Shawnee HS (OK) | 7 | Tulsa Central HS (OK) | 0 | ? | |
| 1921 | W | Sheboygan HS (WI) | 32 | Kenosha HS (WI) | 0 | ? | |
| 1921 | L | Shelbina HS (MO) | 0 | Hannibal HS (MO) | 33 | ? | |
| 1921 | L | Shelbina HS (MO) | 14 | Quincy HS (IL) | 41 | ? | |
| 1921 | W | Shelby HS (NC) | 7 | Asheville HS (NC) | 6 | ? | |
| 1921 | L | Shelbyville YMCA (IN) | 0 | Franklin (IN) | 26 | Franklin, IN | |
| 1921 | L | Shenandoah HS (PA) | 0 | Minersville HS (PA) | 14 | ? | |
| 1921 | L | Shenandoah HS (PA) | 0 | Mount Carmel HS (PA) | 66 | ? | |
| 1921 | L | Shenandoah HS (PA) | 0 | Bloomsburg (PA) | 32 | Bloomsburg, PA | |
| 1921 | L | Shenandoah Military Academy (VA) | 0 | Alexandria Episcopal HS (VA) | 34 | ? | |
| 1921 | W | Shenandoah Military Academy (VA) | 33 | Martinsburg HS (WV) | 0 | ? | |
| 1921 | W | Shenandoah Military Academy (VA) | 26 | Randolph-Macon Academy (VA) | 0 | ? | |
| 1921 | W | Shenandoah Military Academy (VA) | 28 | Randolph-Macon Academy (VA) | 0 | ? | |
| 1921 | W | Shenandoah Military Academy (VA) | 40 | Shepherd (WV) | 0 | Shepherdstown, WV | |
| 1921 | W | Shenandoah Military Academy (VA) | 10 | Staunton Deaf & Dumb School (VA) | 7 | ? | |
| 1921 | L | Shenandoah Military Academy (VA) | 0 | Virginia Episcopal School (VA) | 14 | ? | |
| 1921 | L | Shenandoah Military Academy (VA) | 2 | Washington Central HS (DC) | 7 | ? | |
| 1921 | W | Shenandoah Military Academy (VA) | 7 | Winchester HS (VA) | 0 | ? | |
| 1921 | W | Shepherd (WV) | 18 | Martinsburg HS (WV) | 6 | Shepherdstown, WV | |
| 1921 | L | Shepherd (WV) | 0 | Randolph-Macon Academy (VA) | 78 | Shepherdstown, WV | |
| 1921 | L | Shepherd (WV) | 0 | Saint James Prep School (MD) | 40 | Saint James, MD | |
| 1921 | L | Shepherd (WV) | 0 | Shenandoah Military Academy (VA) | 40 | Shepherdstown, WV | |
| 1921 | T | Shepherd (WV) | 7 | Waynesboro Business School (VA) | 7 | Waynesboro, VA | |
| 1921 | L | Shepherd (WV) | 0 | Frederick HS (MD) | 32 | Shepherdstown, WV | |
| 1921 | L | Shepherd (WV) | 0 | Frederick HS (MD) | 13 | Frederick, MD | |
| 1921 | W | Sheridan HS (WY) | 28 | Big Horn Academy (WY) | 0 | ? | |
| 1921 | W | Sheridan HS (WY) | 21 | Billings HS (MT) | 6 | ? | |
| 1921 | W | Sheridan HS (WY) | 58 | Buffalo HS (WY) | 0 | ? | |
| 1921 | W | Sheridan HS (WY) | 7 | Casper HS (WY) | 0 | ? | |
| 1921 | W | Sheridan HS (WY) | 20 | Laramie HS (WY) | 0 | ? | |
| 1921 | W | Sheridan HS (WY) | 59 | Newcastle HS (WY) | 0 | ? | |
| 1921 | W | Sheridan HS (WY) | 74 | Yellowstone County HS (WY) | 0 | ? | |
| 1921 | T | Sherman Indian School (CA) | 0 | California Freshmen | 0 | ? | |
| 1921 | W | Sherman Indian School (CA) | 14 | Fullerton College (CA) | 6 | ? | |
| 1921 | L | Sherman Indian School (CA) | 0 | Long Beach HS (CA) | 7 | ? | |
| 1921 | W | Sherman Indian School (CA) | 40 | Orange HS (CA) | 0 | ? | |
| 1921 | T | Sherman Indian School (CA) | 0 | Redlands (CA) | 0 | ? | |
| 1921 | W | Sherman Indian School (CA) | 28 | San Bernardino American Legion (CA) | 0 | ? | |
| 1921 | W | Sherman Indian School (CA) | 9 | Whittier B Team (CA) | 0 | ? | |
| 1921 | W | Sherrill HS (NY) | 14 | Auburn HS (NY) | 3 | ? | |
| 1921 | L | Sherrill HS (NY) | 0 | Cortland HS (NY) | 7 | ? | |
| 1921 | W | Sherrill HS (NY) | 27 | Ilion HS (NY) | 13 | ? | |
| 1921 | L | Sherrill HS (NY) | 7 | Oneida HS (NY) | 28 | ? | |
| 1921 | W | Sherrill HS (NY) | 13 | Rome Free Academy (NY) | 0 | ? | |
| 1921 | W | Sherrill HS (NY) | 55 | Syracuse East HS (NY) | 0 | ? | |
| 1921 | W | Sherrill HS (NY) | 12 | Utica Free Academy (NY) | 0 | ? | |
| 1921 | L | Shinnston HS (WV) | 0 | Belington HS (WV) | 12 | ? | |
| 1921 | W | Shinnston HS (WV) | 13 | Belington HS (WV) | 0 | ? | |
| 1921 | L | Shinnston HS (WV) | 0 | Fairmont East Side HS (WV) | 26 | ? | |
| 1921 | L | Shinnston HS (WV) | 0 | Mannington HS (WV) | 42 | ? | |
| 1921 | L | Shinnston HS (WV) | 0 | Morgantown HS (WV) | 24 | ? | |
| 1921 | L | Shinnston HS (WV) | 0 | West Union HS (WV) | 45 | ? | |
| 1921 | L | Shinnston HS (WV) | 0 | Weston HS (WV) | 59 | ? | |
| 1921 | W | Shippensburg (PA) | 13 | Bloomsburg (PA) | 0 | Shippensburg, PA | |
| 1921 | W | Shippensburg (PA) | 14 | Dickinson JV (PA) | 7 | Shippensburg, PA | |
| 1921 | T | Shippensburg (PA) | 7 | Mercersburg Academy JV (PA) | 7 | ? | Shippensburg JV? |
| 1921 | W | Shippensburg (PA) | 1 | Scotland School (PA) | 0 | Shippensburg, PA | Scotland School Forfeits |
| 1921 | W | Shippensburg (PA) | 33 | Lebanon Valley JV (PA) | 0 | Shippensburg, PA | |
| 1921 | W | Shippensburg (PA) | 63 | West Chester (PA) | 7 | Shippensburg, PA | |
| 1921 | W | Shippensburg (PA) | 14 | Franklin & Marshall Academy (PA) | 7 | Lancaster, PA | |
| 1921 | T | Shippensburg (PA) | 7 | Millersville (PA) | 7 | Millersville, PA | |
| 1921 | L | Shorter College (AR) | 0 | Arkansas Baptist | 52 | ? | |
| 1921 | L | Shorter College (AR) | 7 | Arkansas-Pine Bluff | 14 | ? | |
| 1921 | L | Shorter College (AR) | 0 | Philander-Smith (AR) | 7 | ? | |
| 1921 | L | Shoshone HS (ID) | 6 | Filer HS (ID) | 96 | ? | |
| 1921 | W | Shreveport HS (LA) | 26 | Baton Rouge HS (LA) | 0 | ? | |
| 1921 | W | Shreveport HS (LA) | 28 | Jackson HS (MS) | 7 | ? | |
| 1921 | L | Shreveport HS (LA) | 7 | Pine Bluff HS (AR) | 42 | ? | |
| 1921 | L | Shreveport HS (LA) | 0 | Wiley (TX) | 115 | ? | |
| 1921 | W | Shurtleff (IL) | 6 | Eastern Illinois | 3 | Charleston, IL | |
| 1921 | L | Shurtleff (IL) | 0 | Illinois College | 59 | Jacksonville, IL | |
| 1921 | L | Shurtleff (IL) | 0 | McKendree (IL) | 7 | Lebanon, IL | |
| 1921 | T | Shurtleff (IL) | 7 | Southern Illinois | 7 | Carbondale, IL | |
| 1921 | L | Shurtleff (IL) | 0 | Millikin (IL) | 69 | Alton, IL | |
| 1921 | W | Shurtleff (IL) | 35 | Blackburn (IL) | 13 | Carlinville, IL | |
| 1921 | L | Shurtleff (IL) | 0 | Saint Viator (IL) | 86 | Bourbonnais, IL | |
| 1921 | L | Si Tanka (SD) | 0 | Columbus (SD) | 30 | ? | |
| 1921 | W | Si Tanka (SD) | 46 | Flandreau Indian School (SD) | 0 | ? | |
| 1921 | L | Si Tanka (SD) | 0 | South Dakota St. | 60 | Brookings, SD | |
| 1921 | W | Si Tanka (SD) | 13 | Trinity (IA) | 0 | ? | |
| 1921 | L | Si Tanka (SD) | 0 | Yankton (SD) | 14 | Huron, SD | |
| 1921 | W | Si Tanka (SD) | 19 | South Dakota Tech | 0 | ? | |
| 1921 | L | Sidney HS (MT) | 0 | Forsyth HS (MT) | 48 | ? | |
| 1921 | L | Sidney HS (NE) | 0 | Alliance HS (NE) | 83 | ? | |
| 1921 | W | Sidney HS (NE) | 7 | Sterling HS (CO) | 6 | ? | |
| 1921 | L | Sidney HS (NE) | 7 | Sterling HS (CO) | 25 | ? | |
| 1921 | W | Sidney HS (OH) | 53 | Saint Marys HS (OH) | 0 | ? | |
| 1921 | W | Sidney HS (OH) | 22 | Saint Marys HS (OH) | 0 | ? | |
| 1921 | L | Siloam Springs HS (AR) | 14 | Rogers HS (AR) | 25 | ? | |
| 1921 | L | Siloam Springs HS (AR) | 0 | Rogers HS (AR) | 60 | ? | |
| 1921 | L | Silsbee HS (TX) | 0 | Beaumont HS (TX) | 26 | ? | |
| 1921 | L | Simmons (KY) | 7 | Fisk (TN) | 13 | ? | |
| 1921 | W | Simmons (KY) | 39 | Kentucky St. | 0 | ? | |
| 1921 | W | Simmons (KY) | 68 | Lincoln (MO) | 0 | ? | |
| 1921 | L | Simmons (KY) | 7 | Louisville Central HS (KY) | 13 | ? | |
| 1921 | L | Simmons (KY) | 0 | West Virginia St. | 40 | ? | |
| 1921 | L | Simmons (KY) | 0 | Wilberforce (OH) | 6 | ? | |
| 1921 | L | Simpson (IA) | 0 | Coe (IA) | 70 | Indianola, IA | |
| 1921 | L | Simpson (IA) | 0 | Graceland (IA) | 31 | Lamoni, IA | |
| 1921 | W | Simpson (IA) | 7 | Parsons (IA) | 0 | Indianola, IA | |
| 1921 | L | Simpson (IA) | 7 | Upper Iowa | 13 | Indianola, IA | |
| 1921 | W | Simpson (IA) | 7 | William Penn (IA) | 0 | Oskaloosa, IA | |
| 1921 | L | Simpson (IA) | 0 | Grinnell (IA) | 35 | Indianola, IA | |
| 1921 | L | Simpson (IA) | 0 | Cornell College (IA) | 56 | Mount Vernon, IA | |
| 1921 | T | Simpson (IA) | 7 | Iowa Wesleyan | 7 | Mount Pleasant, IA | |
| 1921 | L | Sistersville HS (WV) | 0 | Bellaire HS (OH) | 33 | ? | |
| 1921 | L | Sistersville HS (WV) | 6 | Marietta JV (OH) | 14 | ? | |
| 1921 | L | Sistersville HS (WV) | 0 | Moundsville HS (WV) | 53 | ? | |
| 1921 | W | Sistersville HS (WV) | 13 | Saint Marys HS (WV) | 0 | ? | |
| 1921 | W | Sistersville HS (WV) | 7 | Saint Marys HS (WV) | 0 | ? | |
| 1921 | L | Sistersville HS (WV) | 2 | Shadyside HS (OH) | 14 | ? | |
| 1921 | L | Sistersville HS (WV) | 0 | Wellsburg HS (WV) | 7 | ? | |
| 1921 | W | Sistersville HS (WV) | 45 | Woodsfield HS (OH) | 7 | ? | |
| 1921 | W | Skiatook HS (OK) | 20 | Collinsville HS (OK) | 0 | ? | |
| 1921 | L | Slayton HS (MN) | 0 | Pipestone HS (MN) | 49 | ? | |
| 1921 | W | Sleepy Eye HS (MN) | 108 | Lamberton HS (MN) | 0 | ? | |
| 1921 | T | Sleepy Eye HS (MN) | 0 | Mankato HS (MN) | 0 | ? | |
| 1921 | W | Sleepy Eye HS (MN) | 35 | New Ulm HS (MN) | 6 | ? | |
| 1921 | W | Sleepy Eye HS (MN) | 40 | Redwood Falls HS (MN) | 6 | ? | |
| 1921 | W | Sleepy Eye HS (MN) | 28 | Saint James HS (MN) | 3 | ? | |
| 1921 | L | Sleepy Eye HS (MN) | 0 | Saint Peter HS (MN) | 13 | ? | |
| 1921 | W | Sleepy Eye HS (MN) | 36 | Springfield HS (MN) | 0 | ? | |
| 1921 | W | Slippery Rock (PA) | 39 | Alliance (PA) | 0 | ? | |
| 1921 | W | Slippery Rock (PA) | 49 | California (PA) | 0 | ? | |
| 1921 | W | Slippery Rock (PA) | 13 | Carnegie Mellon Freshmen (PA) | 6 | ? | |
| 1921 | L | Slippery Rock (PA) | 0 | Greensburg HS (PA) | 25 | Greensburg, PA | |
| 1921 | W | Slippery Rock (PA) | 35 | Grove City JV (PA) | 3 | Slippery Rock, PA | |
| 1921 | W | Slippery Rock (PA) | 42 | Indiana (PA) | 0 | Indiana, PA | |
| 1921 | L | Slippery Rock (PA) | 0 | Kiski Academy (PA) | 14 | ? | |
| 1921 | L | Slippery Rock (PA) | 0 | Pittsburgh Freshmen (PA) | 26 | ? | |
| 1921 | W | Smithfield HS (NC) | 12 | Odd Fellows Orphanage | 0 | ? | |
| 1921 | L | Smithfield HS (NC) | 7 | Odd Fellows Orphanage | 14 | ? | |
| 1921 | L | Smithfield HS (NC) | 0 | Oxford HS (NC) | 7 | ? | |
| 1921 | W | Smithfield HS (NC) | 7 | Raleigh HS (NC) | 0 | ? | |
| 1921 | L | Smithfield HS (NC) | 0 | Sanford HS (NC) | 20 | ? | |
| 1921 | W | Smithfield HS (NC) | 7 | Wilson HS (NC) | 0 | ? | |
| 1921 | L | Smithfield HS (WV) | 0 | Follansbee HS (WV) | 46 | ? | |
| 1921 | L | Smithfield HS (WV) | 0 | Richland District HS (WV) | 28 | ? | |
| 1921 | L | Smyrna HS (DE) | 0 | Newark HS (DE) | 67 | ? | |
| 1921 | W | Snohomish HS (WA) | 28 | Granite Falls HS (WA) | 0 | ? | |
| 1921 | L | Solvay HS (NY) | 0 | Oneida HS (NY) | 62 | ? | |
| 1921 | W | Somerset HS (KY) | 20 | Cumberland (KY) | 0 | ? | |
| 1921 | L | Somersworth HS (NH) | 0 | Haverhill Saint James HS (MA) | 46 | ? | |
| 1921 | L | Somerville HS (MA) | 0 | Brookline HS (MA) | 2 | ? | |
| 1921 | L | Somerville HS (MA) | 0 | Cambridge Latin & HS (MA) | 14 | ? | |
| 1921 | L | Somerville HS (MA) | 0 | Everett HS (MA) | 6 | ? | |
| 1921 | L | Somerville HS (MA) | 7 | Malden HS (MA) | 17 | ? | |
| 1921 | T | Somerville HS (MA) | 0 | Medford HS (MA) | 0 | ? | |
| 1921 | L | Somerville HS (MA) | 0 | Newton North HS (MA) | 41 | ? | |
| 1921 | L | Somerville HS (NJ) | 6 | Bernards HS (NJ) | 13 | ? | |
| 1921 | T | Somerville HS (NJ) | 0 | Flemington HS (NJ) | 0 | ? | |
| 1921 | T | Somerville HS (NJ) | 13 | Irvington HS (NJ) | 13 | ? | |
| 1921 | W | Somerville HS (NJ) | 20 | Roselle HS (NJ) | 7 | ? | |
| 1921 | L | Somerville HS (NJ) | 0 | Rutgers Prep School (NJ) | 7 | ? | |
| 1921 | W | Somerville HS (NJ) | 12 | Westfield HS (NJ) | 7 | ? | |
| 1921 | L | Sour Lake HS (TX) | 0 | Beaumont HS (TX) | 33 | ? | |
| 1921 | T | Sour Lake HS (TX) | 7 | Orange HS (TX) | 7 | ? | |
| 1921 | W | South Bend HS (IN) | 48 | Chicago Nicholas Senn HS (IL) | 7 | ? | |
| 1921 | W | South Carolina | 13 | Citadel (SC) | 0 | Columbia, SC | |
| 1921 | W | South Carolina | 21 | Clemson (SC) | 0 | Columbia, SC | |
| 1921 | T | South Carolina | 7 | North Carolina | 7 | Columbia, SC | |
| 1921 | W | South Carolina | 48 | Presbyterian (SC) | 0 | Columbia, SC | |
| 1921 | W | South Carolina | 13 | Erskine (SC) | 7 | Columbia, SC | |
| 1921 | T | South Carolina | 7 | Florida | 7 | Tampa, FL | |
| 1921 | W | South Carolina | 7 | Newberry (SC) | 0 | Columbia, SC | |
| 1921 | L | South Carolina | 0 | Furman (SC) | 7 | Greenville, SC | |
| 1921 | W | South Carolina St. | 14 | Morris (SC) | 0 | Orangeburg, SC | |
| 1921 | L | South City HS | 7 | Palo Alto HS (CA) | 42 | ? | |
| 1921 | L | South Dakota | 0 | Creighton (NE) | 19 | Omaha, NE | |
| 1921 | W | South Dakota | 7 | Dakota Wesleyan (SD) | 0 | Mitchell, SD | |
| 1921 | L | South Dakota | 0 | North Dakota | 21 | Grand Forks, ND | |
| 1921 | W | South Dakota | 28 | Yankton (SD) | 0 | Vermillion, SD | |
| 1921 | L | South Dakota | 0 | Michigan St. | 14 | East Lansing, MI | |
| 1921 | L | South Dakota | 0 | Illinois | 52 | Urbana, IL | |
| 1921 | L | South Dakota | 0 | South Dakota St. | 9 | Vermillion, SD | |
| 1921 | W | South Dakota St. | 7 | Creighton (NE) | 0 | Omaha, NE | |
| 1921 | W | South Dakota St. | 54 | North Dakota St. | 0 | Fargo, ND | |
| 1921 | W | South Dakota St. | 60 | Si Tanka (SD) | 0 | Brookings, SD | |
| 1921 | W | South Dakota St. | 55 | Yankton (SD) | 0 | Yankton, SD | |
| 1921 | W | South Dakota St. | 40 | Northern St. (SD) | 0 | Brookings, SD | |
| 1921 | W | South Dakota St. | 27 | North Dakota | 14 | Brookings, SD | |
| 1921 | L | South Dakota St. | 3 | Wisconsin | 24 | Madison, WI | |
| 1921 | W | South Dakota St. | 9 | South Dakota | 0 | Vermillion, SD | |
| 1921 | W | South Dakota Tech | 14 | Columbus (SD) | 6 | ? | |
| 1921 | L | South Dakota Tech | 0 | Dakota Wesleyan (SD) | 34 | Mitchell, SD | |
| 1921 | T | South Dakota Tech | 0 | Montana Tech | 0 | Rapid City, SD | |
| 1921 | L | South Dakota Tech | 6 | Black Hills St. (SD) | 13 | Rapid City, SD | |
| 1921 | L | South Dakota Tech | 6 | Black Hills St. (SD) | 7 | Rapid City, SD | |
| 1921 | W | South Dakota Tech | 20 | Chadron St. (NE) | 13 | ? | |
| 1921 | L | South Dakota Tech | 0 | Si Tanka (SD) | 19 | ? | |
| 1921 | L | South Hills HS (PA) | 0 | New Castle HS (PA) | 18 | ? | |
| 1921 | W | South Hills HS (PA) | 33 | Pittsburgh 5th Ave. HS (PA) | 0 | ? | |
| 1921 | T | South Hills HS (PA) | 13 | Pittsburgh Allegheny HS (PA) | 13 | ? | |
| 1921 | L | South Hills HS (PA) | 0 | Pittsburgh Peabody HS (PA) | 20 | ? | |
| 1921 | L | South Hills HS (PA) | 0 | Pittsburgh South HS (PA) | 13 | ? | |
| 1921 | L | South Hills HS (PA) | 0 | Schenley HS (PA) | 18 | ? | |
| 1921 | T | South Hills HS (PA) | 0 | Wellsboro HS (PA) | 0 | ? | |
| 1921 | L | South Hills HS (PA) | 7 | Westinghouse HS (PA) | 20 | ? | |
| 1921 | L | South Norwalk HS (CT) | 0 | Crosby HS (CT) | 49 | ? | |
| 1921 | L | South Orange Columbia HS (NJ) | 6 | Dover HS (NJ) | 7 | ? | |
| 1921 | L | South Orange Columbia HS (NJ) | 6 | East Orange HS (NJ) | 20 | ? | |
| 1921 | L | South Orange Columbia HS (NJ) | 0 | Newark Central HS (NJ) | 24 | ? | |
| 1921 | L | South Orange Columbia HS (NJ) | 0 | Orange HS (NJ) | 17 | ? | |
| 1921 | W | South Orange Columbia HS (NJ) | 53 | Red Bank HS (NJ) | 0 | ? | |
| 1921 | T | South Orange Columbia HS (NJ) | 0 | Saint Benedict Prep School (NJ) | 0 | ? | |
| 1921 | W | South Orange Columbia HS (NJ) | 14 | West Orange HS (NJ) | 0 | ? | |
| 1921 | L | South Park HS | 0 | Beaumont HS (TX) | 27 | ? | |
| 1921 | L | South Park HS | 0 | Orange HS (TX) | 33 | ? | |
| 1921 | L | South River HS (NJ) | 0 | Bernards HS (NJ) | 3 | ? | |
| 1921 | T | Southeast Missouri St. | 0 | Arkansas St. | 0 | Cape Girardeau, MO | |
| 1921 | L | Southeast Missouri St. | 0 | Missouri St. | 7 | Springfield, MO | |
| 1921 | L | Southeast Missouri St. | 0 | Saint Louis (MO) | 7 | Saint Louis, MO | |
| 1921 | W | Southeast Missouri St. | 13 | Southern Illinois | 0 | Cape Girardeau, MO | |
| 1921 | L | Southeast Missouri St. | 0 | Missouri S&T | 24 | Cape Girardeau, MO | |
| 1921 | T | Southeast Missouri St. | 0 | Southern Illinois | 0 | Carbondale, IL | |
| 1921 | L | Southeastern Oklahoma St. | 0 | Austin (TX) | 34 | ? | |
| 1921 | W | Southeastern Oklahoma St. | 24 | Dallas (TX) | 0 | ? | |
| 1921 | W | Southeastern Oklahoma St. | 0 | East Central (OK) | 0 | ? | East Central Forfeits |
| 1921 | W | Southeastern Oklahoma St. | 34 | Murray St. (OK) | 0 | ? | |
| 1921 | W | Southeastern Oklahoma St. | 28 | Northeastern St. (OK) | 7 | ? | |
| 1921 | W | Southeastern Oklahoma St. | 34 | Northwestern Oklahoma St. | 7 | ? | |
| 1921 | W | Southeastern Oklahoma St. | 48 | Roff American Legion | 0 | ? | |
| 1921 | W | Southeastern Oklahoma St. | 46 | Southwestern Military Academy | 0 | ? | |
| 1921 | L | Southeastern Oklahoma St. | 7 | Texas A&M-Commerce | 14 | Commerce, TX | |
| 1921 | W | Southeastern Oklahoma St. | 9 | Burleson College (TX) | 0 | Durant, OK | |
| 1921 | L | Southern (LA) | 12 | Bishop (TX) | 21 | ? | |
| 1921 | W | Southern (LA) | 20 | New Orleans (LA) | 6 | ? | |
| 1921 | W | Southern (LA) | 16 | New Orleans (LA) | 12 | ? | |
| 1921 | L | Southern (LA) | 6 | Straight (LA) | 20 | ? | |
| 1921 | L | Southern (LA) | 13 | Wiley (TX) | 32 | ? | |
| 1921 | W | Southern (LA) | 6 | Xavier (LA) | 0 | ? | |
| 1921 | L | Southern Arkansas | 0 | Arkansas Freshmen | 13 | Fayetteville, AR | |
| 1921 | W | Southern Arkansas | 6 | Camden HS (AR) | 0 | Magnolia, AR | |
| 1921 | L | Southern Arkansas | 0 | Central Arkansas | 6 | Conway, AR | |
| 1921 | L | Southern Arkansas | 7 | Henderson St. (AR) | 37 | Arkadelphia, AR | |
| 1921 | L | Southern Arkansas | 13 | Louisiana Tech | 22 | Magnolia, AR | |
| 1921 | L | Southern Arkansas | 0 | Ouachita Baptist (AR) | 40 | Arkadelphia, AR | |
| 1921 | L | Southern Arkansas | 0 | Arkansas Tech | 20 | Russellville, AR | |
| 1921 | W | Southern Arkansas | 13 | Arkansas-Monticello | 7 | Magnolia, AR | |
| 1921 | W | Southern California | 42 | Occidental (CA) | 0 | Los Angeles, CA | |
| 1921 | W | Southern California | 7 | Oregon St. | 0 | Pasadena, CA | |
| 1921 | W | Southern California | 35 | Pomona-Pitzer (CA) | 7 | Los Angeles, CA | |
| 1921 | W | Southern California | 28 | San Pedro Submarine Base (CA) | 0 | ? | |
| 1921 | W | Southern California | 14 | Whittier (CA) | 0 | Los Angeles, CA | |
| 1921 | W | Southern California | 62 | USS Arizona | 0 | Los Angeles, CA | |
| 1921 | W | Southern California | 35 | USS New York | 0 | Los Angeles, CA | |
| 1921 | W | Southern California | 28 | Washington St. | 7 | Pasadena, CA | |
| 1921 | L | Southern California | 7 | California | 38 | Berkeley, CA | |
| 1921 | W | Southern California | 70 | California Tech | 0 | Los Angeles, CA | |
| 1921 | W | Southern California | 34 | San Pedro Submarine Base (CA) | 0 | Los Angeles, CA | |
| 1921 | W | Southern Illinois | 2 | Eastern Illinois | 0 | Carbondale, IL | |
| 1921 | L | Southern Illinois | 0 | McKendree (IL) | 20 | Lebanon, IL | |
| 1921 | T | Southern Illinois | 7 | Shurtleff (IL) | 7 | Carbondale, IL | |
| 1921 | L | Southern Illinois | 0 | Southeast Missouri St. | 13 | Cape Girardeau, MO | |
| 1921 | W | Southern Illinois | 7 | McKendree (IL) | 0 | Carbondale, IL | |
| 1921 | T | Southern Illinois | 0 | Sesser Athletics (IL) | 0 | Carbondale, IL | |
| 1921 | T | Southern Illinois | 0 | Southeast Missouri St. | 0 | Carbondale, IL | |
| 1921 | L | Southern Methodist (TX) | 0 | Arkansas | 14 | Fort Smith, AR | |
| 1921 | L | Southern Methodist (TX) | 6 | Austin (TX) | 17 | Dallas, TX | |
| 1921 | L | Southern Methodist (TX) | 0 | Baylor (TX) | 28 | Waco, TX | |
| 1921 | T | Southern Methodist (TX) | 0 | Southwestern (TX) | 0 | Dallas, TX | |
| 1921 | L | Southern Methodist (TX) | 0 | Rice (TX) | 7 | Houston, TX | |
| 1921 | W | Southern Methodist (TX) | 3 | Howard Payne (TX) | 0 | Dallas, TX | |
| 1921 | L | Southern Methodist (TX) | 0 | Texas A&M | 13 | Dallas, TX | |
| 1921 | L | Southern Methodist (TX) | 6 | Texas Christian | 13 | Dallas, TX | |
| 1921 | L | Southern Methodist Freshmen (TX) | 0 | College of Marshall (TX) | 7 | ? | |
| 1921 | W | Southern Mississippi | 37 | Ellisville Jones County HS (MS) | 0 | Hattiesburg, MS | |
| 1921 | L | Southern Mississippi | 13 | Loyola (LA) | 25 | Hattiesburg, MS | |
| 1921 | L | Southern Mississippi | 0 | Millsaps (MS) | 27 | Jackson, MS | |
| 1921 | W | Southern Mississippi | 113 | Raleigh Smith County HS (MS) | 0 | Hattiesburg, MS | |
| 1921 | L | Southern Mississippi | 0 | Saint Stanislaus College (MS) | 49 | Bay Saint Louis, MS | |
| 1921 | W | Southern Mississippi | 20 | Ellisville HS (MS) | 0 | Ellisville, MS | |
| 1921 | L | Southern Mississippi | 0 | Poplarville HS (MS) | 40 | Hattiesburg, MS | |
| 1921 | W | Southwestern (KS) | 10 | Bethany (KS) | 7 | Lindsborg, KS | |
| 1921 | W | Southwestern (KS) | 28 | Chilocco Indian School (OK) | 0 | Winfield, KS | |
| 1921 | L | Southwestern (KS) | 0 | College of Emporia (KS) | 12 | Winfield, KS | |
| 1921 | L | Southwestern (KS) | 0 | Emporia St. (KS) | 61 | Emporia, KS | |
| 1921 | L | Southwestern (KS) | 0 | Pittsburg St. (KS) | 14 | Pittsburg, KS | |
| 1921 | W | Southwestern (KS) | 28 | Sterling (KS) | 0 | Winfield, KS | |
| 1921 | W | Southwestern (KS) | 7 | Wichita St. (KS) | 0 | Winfield, KS | |
| 1921 | W | Southwestern (KS) | 10 | Friends (KS) | 7 | Wichita, KS | |
| 1921 | L | Southwestern (KS) | 7 | Fort Hays St. (KS) | 14 | Hays, KS | |
| 1921 | L | Southwestern (TX) | 10 | Austin (TX) | 17 | Georgetown, TX | Snyder Field |
| 1921 | L | Southwestern (TX) | 0 | Baylor (TX) | 16 | Waco, TX | |
| 1921 | L | Southwestern (TX) | 0 | Rice (TX) | 27 | Houston, TX | |
| 1921 | T | Southwestern (TX) | 0 | Southern Methodist (TX) | 0 | Dallas, TX | |
| 1921 | L | Southwestern (TX) | 0 | Texas | 44 | Austin, TX | |
| 1921 | L | Southwestern (TX) | 0 | Texas St. | 10 | Georgetown, TX | |
| 1921 | L | Southwestern (TX) | 7 | Howard Payne (TX) | 34 | Brownwood, TX | |
| 1921 | L | Southwestern Military Academy | 0 | Southeastern Oklahoma St. | 46 | ? | |
| 1921 | L | Southwestern Military Academy | 7 | Terrill Prep School (TX) | 21 | ? | |
| 1921 | L | Southwestern Oklahoma St. | 14 | Central Oklahoma | 21 | ? | |
| 1921 | W | Southwestern Oklahoma St. | 1 | East Central (OK) | 0 | ? | East Central Forfeits |
| 1921 | W | Southwestern Oklahoma St. | 14 | Kingfisher (OK) | 0 | ? | |
| 1921 | T | Southwestern Oklahoma St. | 14 | Northwestern Oklahoma St. | 14 | ? | |
| 1921 | W | Southwestern Oklahoma St. | 13 | Oklahoma Baptist University | 0 | Shawnee, OK | |
| 1921 | L | Southwestern Oklahoma St. | 0 | Oklahoma St. | 53 | Stillwater, OK | |
| 1921 | W | Southwestern Oklahoma St. | 21 | University Prep School (OK) | 7 | ? | |
| 1921 | T | Southwestern Oklahoma St. | 7 | Oklahoma City (OK) | 7 | Weatherford, OK | |
| 1921 | L | Southwestern Oklahoma St. | 0 | Phillips (OK) | 14 | Enid, OK | |
| 1921 | W | Spencer HS (WV) | 14 | Ceredo-Kenova HS (WV) | 0 | ? | |
| 1921 | W | Spencer HS (WV) | 52 | East Bank HS (WV) | 0 | ? | |
| 1921 | W | Spencer HS (WV) | 7 | Moundsville HS (WV) | 0 | ? | |
| 1921 | W | Spencer HS (WV) | 21 | New Martinsville HS (WV) | 19 | ? | |
| 1921 | W | Spencer HS (WV) | 35 | West Union HS (WV) | 7 | ? | |
| 1921 | W | Spencer HS (WV) | 7 | West Virginia Tech | 0 | ? | |
| 1921 | L | Spirit Lake HS (IA) | 0 | Cedar Rapids HS (IA) | 20 | ? | |
| 1921 | L | Spokane College (WA) | 0 | Eastern Washington | 52 | Spokane, WA | |
| 1921 | L | Spokane University (WA) | 0 | Eastern Washington | 48 | Cheney, WA | |
| 1921 | L | Spooner HS (WI) | 0 | Duluth Cathedral HS (MN) | 53 | ? | |
| 1921 | L | Spring Hill (AL) | 7 | Louisiana St. | 41 | Baton Rouge, LA | |
| 1921 | W | Spring Hill (AL) | 28 | Loyola (LA) | 7 | Mobile, AL | |
| 1921 | W | Spring Hill (AL) | 41 | Marion Military Institute (AL) | 0 | Mobile, AL | |
| 1921 | L | Spring Hill (AL) | 7 | Mississippi College | 28 | Mobile, AL | |
| 1921 | L | Spring Hill (AL) | 7 | Alabama | 27 | Tuscaloosa, AL | |
| 1921 | W | Spring Hill (AL) | 84 | Jefferson (LA) | 6 | Mobile, AL | |
| 1921 | L | Spring Hill (AL) | 0 | Auburn (AL) | 44 | Montgomery, AL | |
| 1921 | W | Spring Hill (AL) | 7 | Samford (AL) | 0 | Mobile, AL | |
| 1921 | T | Spring Hill HS (AL) | 0 | Jackson Agricultural School (AL) | 0 | ? | |
| 1921 | L | Spring Valley HS (MN) | 0 | Lanesboro HS (MN) | 14 | ? | |
| 1921 | L | Spring Valley HS (MN) | 0 | Lanesboro HS (MN) | 28 | ? | |
| 1921 | W | Spring Valley HS (NY) | 6 | Dumont HS (NJ) | 0 | ? | |
| 1921 | W | Spring Valley HS (NY) | 13 | Dumont HS (NJ) | 0 | ? | |
| 1921 | L | Spring Valley HS (NY) | 6 | New York Military Academy JV | 15 | ? | |
| 1921 | L | Spring Valley HS (NY) | 0 | Nyack HS (NY) | 7 | ? | |
| 1921 | W | Spring Valley HS (NY) | 19 | Nyack HS (NY) | 7 | ? | |
| 1921 | T | Spring Valley HS (NY) | 6 | Ramsey HS (NJ) | 6 | ? | |
| 1921 | W | Spring Valley HS (NY) | 17 | Rutherford East HS (NJ) | 0 | ? | |
| 1921 | W | Springfield (MA) | 26 | Amherst (MA) | 0 | Springfield, MA | |
| 1921 | T | Springfield (MA) | 0 | Brown (RI) | 0 | Springfield, MA | |
| 1921 | L | Springfield (MA) | 0 | Fordham (NY) | 14 | Springfield, MA | |
| 1921 | T | Springfield (MA) | 0 | New Hampshire | 0 | Springfield, MA | |
| 1921 | W | Springfield (MA) | 40 | Niagara (NY) | 0 | Springfield, MA | |
| 1921 | W | Springfield (MA) | 34 | Stevens Tech (NJ) | 18 | Hoboken, NJ | |
| 1921 | L | Springfield (MA) | 6 | Army (NY) | 28 | West Point, NY | |
| 1921 | L | Springfield (MA) | 0 | Detroit (MI) | 21 | Detroit, MI | |
| 1921 | W | Springfield (MA) | 13 | Colby (ME) | 6 | Springfield, MA | |
| 1921 | L | Springfield (MA) | 0 | Holy Cross (MA) | 12 | Springfield, MA | |
| 1921 | L | Springfield (MA) | 0 | Cornell (NY) | 14 | Ithaca, NY | |
| 1921 | W | Springfield B Team (MA) | 14 | Bridgeport HS (CT) | 7 | ? | |
| 1921 | L | Springfield Central HS (MO) | 9 | Little Rock HS (AR) | 49 | ? | |
| 1921 | W | Springfield HS | 7 | Westminster College (UT) | 0 | ? | |
| 1921 | L | Springfield HS (IL) | 0 | Jacksonville HS (IL) | 7 | ? | |
| 1921 | W | Springfield HS (IL) | 14 | Lincoln HS (IL) | 0 | ? | |
| 1921 | T | Springfield HS (MO) | 7 | Joplin HS (MO) | 7 | ? | |
| 1921 | W | Springfield HS (OH) | 7 | Columbus West HS (OH) | 0 | ? | |
| 1921 | L | Springfield HS (OH) | 21 | Hamilton HS (OH) | 41 | ? | |
| 1921 | W | Springfield HS (OH) | 27 | Marysville HS (OH) | 0 | ? | |
| 1921 | W | Springfield HS (OH) | 14 | Miamisburg HS (OH) | 12 | ? | |
| 1921 | L | Springfield HS (OH) | 0 | Middletown HS (OH) | 41 | ? | |
| 1921 | L | Springfield HS (OH) | 0 | Springfield HS Alumni (OH) | 14 | ? | |
| 1921 | L | Springfield HS (OH) | 6 | Troy HS (OH) | 13 | ? | |
| 1921 | W | Springfield HS (OH) | 41 | Washington Court House HS (OH) | 0 | ? | |
| 1921 | L | Springfield HS (OH) | 0 | Xenia Central HS (OH) | 34 | ? | |
| 1921 | W | Springfield HS Alumni (OH) | 14 | Springfield HS (OH) | 0 | ? | |
| 1921 | L | Springview HS (NE) | 0 | Dallas HS (SD) | 42 | ? | |
| 1921 | L | Stamford HS (CT) | 0 | Ansonia HS (CT) | 7 | ? | |
| 1921 | W | Stamford HS (CT) | 35 | Derby HS (CT) | 0 | ? | |
| 1921 | W | Stamford HS (CT) | 13 | Drum Hill HS (NY) | 0 | ? | |
| 1921 | L | Stamford HS (CT) | 7 | Hartford HS (CT) | 12 | ? | |
| 1921 | L | Stamford HS (CT) | 10 | Mount Vernon HS (NY) | 19 | ? | |
| 1921 | W | Stamford HS (CT) | 13 | New London HS (CT) | 0 | ? | |
| 1921 | W | Stamford HS (CT) | 69 | Norwalk HS (CT) | 0 | ? | |
| 1921 | W | Stamford HS (CT) | 14 | Saint Benedict Prep School (NJ) | 7 | ? | |
| 1921 | W | Stamford HS (CT) | 35 | Upsala | 21 | ? | |
| 1921 | W | Stamford HS (CT) | 80 | Wilby HS | 0 | ? | |
| 1921 | W | Stamford HS JV (CT) | 21 | King School (CT) | 0 | ? | |
| 1921 | L | Stanford (CA) | 7 | California | 42 | Stanford, CA | |
| 1921 | W | Stanford (CA) | 14 | Oregon St. | 7 | Stanford, CA | |
| 1921 | L | Stanford (CA) | 7 | Pacific Fleet (CA) | 27 | Stanford, CA | |
| 1921 | W | Stanford (CA) | 7 | San Francisco Olympic Club (CA) | 0 | Stanford, CA | |
| 1921 | W | Stanford (CA) | 41 | US Marines | 0 | Stanford, CA | |
| 1921 | T | Stanford (CA) | 0 | Washington | 0 | Seattle, WA | |
| 1921 | W | Stanford (CA) | 10 | Saint Mary's (CA) | 7 | Stanford, CA | |
| 1921 | T | Stanford (CA) | 14 | Nevada | 14 | Stanford, CA | |
| 1921 | L | Stanford 145-lb | 6 | William Warren Military School (CA) | 7 | ? | |
| 1921 | W | Stanford Freshmen (CA) | 14 | Berkeley HS (CA) | 7 | ? | |
| 1921 | W | Stanford Freshmen (CA) | 49 | Pacific (CA) | 6 | Stanford, CA | |
| 1921 | W | Stanford Freshmen (CA) | 23 | Selma HS (CA) | 0 | ? | |
| 1921 | L | Stanford HS (MT) | 0 | Harlowton HS (MT) | 52 | ? | |
| 1921 | W | Stanford JV (CA) | 7 | Potter School (CA) | 0 | ? | |
| 1921 | W | Stanwood HS (WA) | 40 | Granite Falls HS (WA) | 7 | ? | |
| 1921 | L | Starkey Seminary (NY) | 13 | Cook Academy (NY) | 51 | ? | |
| 1921 | L | Starkey Seminary (NY) | 0 | Cook Academy (NY) | 43 | ? | |
| 1921 | L | Starkville HS (MS) | 6 | Ackerman HS (MS) | 77 | ? | |
| 1921 | L | Staunton Deaf & Dumb School (VA) | 0 | Fork Union Military Academy (VA) | 55 | ? | |
| 1921 | L | Staunton Deaf & Dumb School (VA) | 7 | Shenandoah Military Academy (VA) | 10 | ? | |
| 1921 | W | Staunton Military Academy (VA) | 27 | Augusta Military Academy (VA) | 0 | Staunton, VA | |
| 1921 | W | Staunton Military Academy (VA) | 39 | Fishburne Military School (VA) | 0 | ? | |
| 1921 | L | Staunton Military Academy (VA) | 7 | Navy Freshmen (MD) | 9 | ? | |
| 1921 | W | Staunton Military Academy (VA) | 14 | Norfolk Navy Yard (VA) | 0 | ? | |
| 1921 | W | Staunton Military Academy (VA) | 41 | Pharm. Mater | 0 | ? | |
| 1921 | W | Staunton Military Academy (VA) | 21 | Virginia Military Institute JV | 0 | ? | |
| 1921 | W | Staunton Military Academy (VA) | 26 | Washington & Lee Freshmen (VA) | 0 | ? | |
| 1921 | L | Steam Rollers (RI) | 0 | New London Submarine Base (CT) | 42 | ? | |
| 1921 | L | Steelton AA (PA) | 0 | Lincoln (PA) | 7 | ? | |
| 1921 | W | Steelton HS (PA) | 30 | Bethlehem HS (PA) | 24 | ? | |
| 1921 | L | Steelton HS (PA) | 0 | Harrisburg Tech HS (PA) | 13 | ? | |
| 1921 | T | Steelton HS (PA) | 7 | Mount Carmel HS (PA) | 7 | ? | |
| 1921 | W | Steelton HS (PA) | 26 | Williamsport HS (PA) | 0 | ? | |
| 1921 | W | Stephen HS (MN) | 21 | Crookston HS (MN) | 0 | ? | |
| 1921 | W | Stephen HS (MN) | 14 | Drayton HS (ND) | 7 | ? | |
| 1921 | L | Stephen HS (MN) | 6 | East Grand Forks HS (MN) | 26 | ? | |
| 1921 | L | Stephen HS (MN) | 0 | Grafton HS (ND) | 27 | ? | |
| 1921 | W | Stephen HS (MN) | 39 | Hallock HS (MN) | 0 | ? | |
| 1921 | T | Stephen HS (MN) | 0 | Thief River Falls HS (MN) | 0 | ? | |
| 1921 | W | Stephen HS (MN) | 14 | Warren HS (MN) | 0 | ? | |
| 1921 | W | Stephen HS (MN) | 21 | Warren HS (MN) | 0 | ? | |
| 1921 | L | Sterling (KS) | 0 | Bethany (KS) | 10 | Sterling, KS | |
| 1921 | L | Sterling (KS) | 0 | Fort Hays St. (KS) | 7 | Sterling, KS | |
| 1921 | L | Sterling (KS) | 6 | Friends (KS) | 28 | Wichita, KS | |
| 1921 | L | Sterling (KS) | 0 | Southwestern (KS) | 28 | Winfield, KS | |
| 1921 | L | Sterling (KS) | 0 | Wichita St. (KS) | 7 | Sterling, KS | |
| 1921 | L | Sterling (KS) | 0 | McPherson (KS) | 13 | McPherson, KS | |
| 1921 | W | Sterling (KS) | 6 | Kansas Wesleyan | 0 | Salina, KS | |
| 1921 | W | Sterling HS (CO) | 25 | Akron HS (CO) | 6 | ? | |
| 1921 | L | Sterling HS (CO) | 6 | Brush HS (CO) | 21 | ? | |
| 1921 | W | Sterling HS (CO) | 28 | Fort Morgan HS (CO) | 25 | ? | |
| 1921 | W | Sterling HS (CO) | 16 | Holyoke HS (CO) | 14 | ? | |
| 1921 | L | Sterling HS (CO) | 6 | Merino HS (CO) | 19 | ? | |
| 1921 | W | Sterling HS (CO) | 13 | Merino HS (CO) | 0 | ? | |
| 1921 | L | Sterling HS (CO) | 0 | Scottsbluff HS (NE) | 35 | ? | |
| 1921 | L | Sterling HS (CO) | 6 | Sidney HS (NE) | 7 | ? | |
| 1921 | W | Sterling HS (CO) | 25 | Sidney HS (NE) | 7 | ? | |
| 1921 | L | Sterling HS (CO) | 6 | Sterling HS Alumni (CO) | 24 | ? | |
| 1921 | L | Sterling HS (CO) | 0 | Wray HS (CO) | 21 | ? | |
| 1921 | L | Sterling HS (CO) | 0 | Yuma County HS (CO) | 21 | ? | |
| 1921 | W | Sterling HS Alumni (CO) | 24 | Sterling HS (CO) | 6 | ? | |
| 1921 | L | Stetson (FL) | 0 | Bartow Aviators (FL) | 19 | ? | |
| 1921 | L | Stetson (FL) | 0 | Mercer (GA) | 41 | Macon, GA | |
| 1921 | W | Stetson (FL) | 25 | Orlando American Legion (FL) | 0 | ? | |
| 1921 | L | Stetson (FL) | 0 | Rollins (FL) | 13 | Deland, FL | |
| 1921 | L | Stetson (FL) | 0 | Oglethorpe (GA) | 41 | Deland, FL | |
| 1921 | L | Stevens Tech (NJ) | 0 | Rensselaer Tech (NY) | 23 | Troy, NY | |
| 1921 | L | Stevens Tech (NJ) | 18 | Springfield (MA) | 34 | Hoboken, NJ | |
| 1921 | L | Stevens Tech (NJ) | 0 | Trinity (CT) | 6 | Hoboken, NJ | |
| 1921 | L | Stevens Tech (NJ) | 0 | Wesleyan (CT) | 13 | Middletown, CT | |
| 1921 | L | Stevens Tech (NJ) | 0 | Swarthmore (PA) | 13 | Hoboken, NJ | |
| 1921 | T | Stevens Tech (NJ) | 0 | Haverford (PA) | 0 | Hoboken, NJ | |
| 1921 | W | Stevens Tech (NJ) | 34 | Maine | 7 | Hoboken, NJ | |
| 1921 | L | Stevens Trade School (PA) | 0 | Franklin & Marshall Academy (PA) | 55 | ? | |
| 1921 | L | Stevens Trade School (PA) | 0 | Harrisburg Tech HS (PA) | 38 | ? | |
| 1921 | T | Stevens Trade School (PA) | 0 | Lebanon Valley JV (PA) | 0 | ? | |
| 1921 | L | Stevens Trade School (PA) | 0 | Millersville (PA) | 34 | ? | |
| 1921 | L | Stevens Trade School (PA) | 0 | Perkiomen Seminary (PA) | 51 | ? | |
| 1921 | L | Stevens Trade School (PA) | 0 | Reading HS (PA) | 14 | ? | |
| 1921 | L | Stevens Trade School (PA) | 0 | Tome Institute (MD) | 25 | ? | |
| 1921 | L | Stevens Trade School (PA) | 0 | Williamson Trade School (PA) | 45 | ? | |
| 1921 | W | Stewartville HS (MN) | 26 | Dodge Center HS (MN) | 0 | ? | |
| 1921 | W | Stewartville HS (MN) | 26 | Dodge Center HS (MN) | 6 | ? | |
| 1921 | W | Stewartville HS (MN) | 14 | Grand Meadow HS (MN) | 6 | ? | |
| 1921 | L | Stewartville HS (MN) | 0 | Kasson HS (MN) | 40 | ? | |
| 1921 | W | Stewartville HS (MN) | 7 | Lewiston HS (MN) | 6 | ? | |
| 1921 | W | Stewartville HS (MN) | 66 | Lewiston HS (MN) | 0 | ? | |
| 1921 | L | Stewartville HS (MN) | 6 | Pine Island HS (MN) | 33 | ? | |
| 1921 | W | Stigler HS (OK) | 7 | Van Buren HS (AR) | 0 | ? | |
| 1921 | T | Still College (IA) | 0 | Buena Vista (IA) | 0 | Des Moines, IA | |
| 1921 | L | Still College (IA) | 0 | Des Moines (IA) | 38 | ? | |
| 1921 | W | Still College (IA) | 7 | Ellsworth CC (IA) | 0 | Iowa Falls, IA | |
| 1921 | W | Still College (IA) | 7 | Graceland (IA) | 6 | Lamoni, IA | |
| 1921 | L | Still College (IA) | 0 | Northern Iowa | 66 | ? | |
| 1921 | W | Still College (IA) | 19 | Northwest Missouri St. | 0 | ? | |
| 1921 | T | Still College (IA) | 7 | Saint Ambrose (IA) | 7 | Des Moines, IA | |
| 1921 | T | Stillman (AL) | 0 | Miles (AL) | 0 | ? | |
| 1921 | W | Stillwater HS (MN) | 20 | Farmington HS (MN) | 7 | ? | |
| 1921 | W | Stillwater HS (MN) | 27 | Hudson HS (WI) | 0 | ? | |
| 1921 | W | Stillwater HS (MN) | 26 | New Richmond HS (WI) | 20 | ? | |
| 1921 | W | Stillwater HS (MN) | 20 | River Falls HS (WI) | 0 | ? | |
| 1921 | W | Stillwater HS (MN) | 13 | Saint Cloud HS (MN) | 0 | ? | |
| 1921 | W | Stillwater HS (MN) | 13 | Saint Paul Humboldt HS (MN) | 0 | ? | |
| 1921 | W | Stillwater HS (MN) | 20 | White Bear Lake HS (MN) | 7 | ? | |
| 1921 | W | Stillwater HS (MN) | 34 | Winona HS (MN) | 7 | ? | |
| 1921 | L | Stillwater HS (MN) | 0 | Worthington HS (MN) | 7 | ? | |
| 1921 | L | Stockton HS (CA) | 7 | Sacramento HS (CA) | 20 | ? | |
| 1921 | L | Stockton HS (CA) | 0 | Sacramento HS (CA) | 39 | ? | |
| 1921 | L | Stockton HS (CA) | 0 | Selma HS (CA) | 27 | ? | |
| 1921 | L | Stone Hall | 0 | Bloomfield HS (NJ) | 7 | ? | |
| 1921 | W | Stone School (NY) | 14 | Newark Academy (NJ) | 7 | ? | |
| 1921 | L | Stone School (NY) | 0 | Poughkeepsie HS (NY) | 6 | ? | |
| 1921 | L | Stoneham HS (MA) | 6 | Melrose HS (MA) | 16 | ? | |
| 1921 | L | Stoneham HS (MA) | 0 | Wakefield HS (MA) | 41 | ? | |
| 1921 | L | Stonington HS (IL) | 6 | Lincoln HS (IL) | 33 | ? | |
| 1921 | L | Storer College (WV) | 7 | Virginia-Lynchburg | 33 | ? | |
| 1921 | W | Storer College (WV) | 25 | Morgan St. (MD) | 0 | Baltimore, MD | |
| 1921 | W | Straight (LA) | 20 | Southern (LA) | 6 | ? | |
| 1921 | L | Straight (LA) | 0 | Xavier (LA) | 6 | ? | |
| 1921 | L | Strathmore HS (CA) | 6 | Dinuba HS (CA) | 7 | ? | |
| 1921 | L | Strathmore HS (CA) | 0 | Dinuba HS (CA) | 20 | ? | |
| 1921 | L | Stronghurst HS (IL) | 13 | Keokuk HS (IA) | 19 | ? | |
| 1921 | W | Stuyvesant HS (NY) | 6 | Brooklyn Commercial HS (NY) | 0 | ? | |
| 1921 | W | Stuyvesant HS (NY) | 21 | City College of New York Freshmen | 0 | ? | |
| 1921 | W | Stuyvesant HS (NY) | 6 | Clason Military Academy (NY) | 0 | ? | |
| 1921 | L | Stuyvesant HS (NY) | 0 | Dewitt Clinton HS (NY) | 13 | ? | |
| 1921 | W | Stuyvesant HS (NY) | 14 | Evander Childs HS (NY) | 0 | ? | |
| 1921 | W | Stuyvesant HS (NY) | 13 | New York HS of Commerce (NY) | 0 | ? | |
| 1921 | W | Stuyvesant HS (NY) | 28 | New York Morris HS (NY) | 0 | ? | |
| 1921 | W | Stuyvesant HS (NY) | 13 | Paterson HS (NJ) | 0 | ? | |
| 1921 | W | Submarine Base | 6 | Redlands (CA) | 2 | ? | |
| 1921 | L | Suffield School (CT) | 7 | Cushing Academy (MA) | 13 | ? | |
| 1921 | W | Suffield School (CT) | 21 | Roxbury School (CT) | 7 | ? | |
| 1921 | L | Suffolk HS (VA) | 0 | Newport News HS (VA) | 41 | ? | |
| 1921 | W | Sultan HS (WA) | 76 | Granite Falls HS (WA) | 0 | ? | |
| 1921 | L | Sultan HS (WA) | 0 | Granite Falls HS (WA) | 78 | ? | |
| 1921 | L | Summit HS (NJ) | 6 | Chatham HS (NJ) | 20 | ? | |
| 1921 | W | Summit HS (NJ) | 27 | Cranford HS (NJ) | 0 | ? | |
| 1921 | L | Summit HS (NJ) | 0 | Dover HS (NJ) | 38 | ? | |
| 1921 | W | Summit HS (NJ) | 14 | Morristown HS (NJ) | 13 | ? | |
| 1921 | L | Summit HS (NJ) | 0 | Nutley HS (NJ) | 45 | ? | |
| 1921 | L | Summit HS (NJ) | 0 | Orange HS (NJ) | 18 | ? | |
| 1921 | L | Summit HS (NJ) | 0 | Rahway HS (NJ) | 6 | ? | |
| 1921 | W | Summit HS (NJ) | 13 | Roselle HS (NJ) | 0 | ? | |
| 1921 | W | Summit HS (NJ) | 27 | Roselle Park HS (NJ) | 0 | ? | |
| 1921 | W | Summit HS (NJ) | 12 | Westfield HS (NJ) | 7 | ? | |
| 1921 | L | Sumter HS (SC) | 0 | Charleston HS (SC) | 38 | ? | |
| 1921 | L | Sunbury HS (PA) | 0 | Huntingdon HS (PA) | 62 | ? | |
| 1921 | W | Sunbury HS (PA) | 18 | Minersville HS (PA) | 7 | ? | |
| 1921 | L | Sunbury HS (PA) | 0 | Williamsport HS (PA) | 13 | ? | |
| 1921 | W | SUNY-Farmingdale (NY) | 20 | Cooper Union (NY) | 0 | Farmingdale, NY | |
| 1921 | L | SUNY-Farmingdale (NY) | 0 | Delaware | 49 | Newark, DE | |
| 1921 | W | SUNY-Farmingdale (NY) | 48 | Mineola Aviators | 0 | ? | |
| 1921 | L | SUNY-Farmingdale (NY) | 0 | New York Military Academy | 61 | ? | |
| 1921 | L | SUNY-Farmingdale (NY) | 0 | Plainfield AC (NJ) | 2 | ? | |
| 1921 | L | SUNY-Farmingdale (NY) | 2 | Receiving Ship (NY) | 3 | ? | |
| 1921 | L | SUNY-Farmingdale (NY) | 7 | Drexel Institute (PA) | 34 | Philadelphia, PA | |
| 1921 | L | Superior Central HS (WI) | 14 | Duluth Cathedral HS (MN) | 19 | ? | |
| 1921 | L | Superior Dewey HS (WI) | 0 | Duluth Cathedral HS (MN) | 43 | ? | |
| 1921 | L | Superior Dewey HS (WI) | 0 | Duluth Denfeld HS (MN) | 48 | ? | |
| 1921 | L | Superior Dewey HS (WI) | 0 | Superior HS (WI) | 58 | ? | |
| 1921 | W | Superior HS (WI) | 28 | Ashland HS (WI) | 7 | ? | |
| 1921 | W | Superior HS (WI) | 61 | Cloquet HS (MN) | 0 | ? | |
| 1921 | L | Superior HS (WI) | 14 | Duluth Cathedral HS (MN) | 19 | ? | |
| 1921 | W | Superior HS (WI) | 43 | Duluth Central HS (MN) | 0 | ? | |
| 1921 | W | Superior HS (WI) | 21 | Duluth Denfeld HS (MN) | 7 | ? | |
| 1921 | L | Superior HS (WI) | 0 | Marinette HS (WI) | 14 | ? | |
| 1921 | W | Superior HS (WI) | 58 | Superior Dewey HS (WI) | 0 | ? | |
| 1921 | L | Susquehanna (PA) | 0 | Army (NY) | 53 | West Point, NY | |
| 1921 | L | Susquehanna (PA) | 0 | Bucknell (PA) | 62 | Lewisburg, PA | |
| 1921 | L | Susquehanna (PA) | 6 | Colgate (NY) | 21 | Hamilton, NY | |
| 1921 | W | Susquehanna (PA) | 26 | Gallaudet (DC) | 0 | Selinsgrove, PA | |
| 1921 | W | Susquehanna (PA) | 2 | Lebanon Valley (PA) | 0 | Sunbury, PA | |
| 1921 | L | Susquehanna (PA) | 0 | Lehigh (PA) | 22 | Bethlehem, PA | |
| 1921 | L | Susquehanna (PA) | 0 | Thiel (PA) | 12 | Greenville, PA | |
| 1921 | T | Susquehanna (PA) | 0 | Mount Saint Mary's (MD) | 0 | Selinsgrove, PA | |
| 1921 | L | Susquehanna (PA) | 6 | Albright (PA) | 21 | Myerstown, PA | |
| 1921 | W | Swampscott HS (MA) | 23 | Gloucester HS (MA) | 0 | ? | |
| 1921 | L | Swampscott HS (MA) | 0 | Marblehead HS (MA) | 21 | ? | |
| 1921 | L | Swampscott HS (MA) | 7 | Peabody HS (MA) | 35 | ? | |
| 1921 | W | Swampscott HS (MA) | 6 | Revere HS (MA) | 0 | ? | |
| 1921 | T | Swarthmore (PA) | 7 | Franklin & Marshall (PA) | 7 | Lancaster, PA | |
| 1921 | W | Swarthmore (PA) | 55 | Haverford (PA) | 0 | Swarthmore, PA | |
| 1921 | L | Swarthmore (PA) | 6 | Muhlenberg (PA) | 7 | Allentown, PA | |
| 1921 | T | Swarthmore (PA) | 7 | Pennsylvania | 7 | Philadelphia, PA | |
| 1921 | L | Swarthmore (PA) | 7 | Princeton (NJ) | 21 | Princeton, NJ | |
| 1921 | W | Swarthmore (PA) | 13 | Stevens Tech (NJ) | 0 | Hoboken, NJ | |
| 1921 | W | Swarthmore (PA) | 28 | Albright (PA) | 0 | Swarthmore, PA | |
| 1921 | W | Swarthmore (PA) | 7 | Johns Hopkins (MD) | 0 | Swarthmore, PA | |
| 1921 | L | Swarthmore HS (PA) | 0 | Cheltenham HS (PA) | 31 | ? | |
| 1921 | L | Swarthmore HS (PA) | 0 | Darby HS (PA) | 34 | ? | |
| 1921 | L | Swarthmore HS (PA) | 0 | Episcopal Academy (PA) | 27 | ? | |
| 1921 | L | Swarthmore HS (PA) | 0 | Lansdowne HS (PA) | 84 | ? | |
| 1921 | L | Swarthmore HS (PA) | 0 | Media HS (PA) | 35 | ? | |
| 1921 | L | Swarthmore HS (PA) | 0 | Ridley Park HS (PA) | 13 | ? | |
| 1921 | W | Swarthmore Prep School (PA) | 13 | Bordentown Military Institute (NJ) | 0 | ? | |
| 1921 | W | Swarthmore Prep School (PA) | 14 | Bryn Athyn Academy (PA) | 0 | ? | |
| 1921 | W | Swarthmore Prep School (PA) | 13 | Delaware Valley (PA) | 7 | ? | |
| 1921 | W | Swarthmore Prep School (PA) | 47 | Friends Central School (PA) | 0 | ? | |
| 1921 | W | Swarthmore Prep School (PA) | 7 | Penn Charter School (PA) | 0 | ? | |
| 1921 | W | Swarthmore Prep School (PA) | 41 | Pennington Seminary (NJ) | 0 | ? | |
| 1921 | L | Swarthmore Prep School (PA) | 6 | Saint Joseph's Prep School (PA) | 12 | ? | |
| 1921 | L | Swift Memorial JC (TN) | 0 | Jacksonville St. (AL) | 68 | ? | |
| 1921 | T | Swissvale HS (PA) | 7 | North Braddock HS (PA) | 7 | ? | |
| 1921 | L | Swissvale HS (PA) | 3 | Shady Side Academy (PA) | 41 | ? | |
| 1921 | L | Swissvale HS (PA) | 0 | Westinghouse HS (PA) | 35 | ? | |
| 1921 | L | Sylacauga Agriculture School (AL) | 0 | Jacksonville St. (AL) | 68 | ? | |
| 1921 | W | Syracuse (NY) | 28 | Brown (RI) | 0 | Syracuse, NY | |
| 1921 | W | Syracuse (NY) | 14 | Dartmouth (NH) | 7 | New York, NY | |
| 1921 | W | Syracuse (NY) | 35 | Hobart (NY) | 0 | Syracuse, NY | |
| 1921 | L | Syracuse (NY) | 0 | Pittsburgh (PA) | 35 | Pittsburgh, PA | |
| 1921 | L | Syracuse (NY) | 10 | Washington & Jefferson (PA) | 17 | Syracuse, NY | |
| 1921 | W | Syracuse (NY) | 38 | Ohio | 0 | Syracuse, NY | |
| 1921 | W | Syracuse (NY) | 13 | McGill (QC) | 0 | Montreal, QC (Canada) | |
| 1921 | W | Syracuse (NY) | 42 | Maryland | 0 | Syracuse, NY | |
| 1921 | W | Syracuse (NY) | 14 | Colgate (NY) | 0 | Syracuse, NY | |
| 1921 | W | Syracuse Central HS (NY) | 7 | Auburn HS (NY) | 6 | ? | |
| 1921 | W | Syracuse Central HS (NY) | 12 | Geneva HS (NY) | 0 | ? | |
| 1921 | W | Syracuse Central HS (NY) | 22 | North Tonawanda HS (NY) | 10 | ? | |
| 1921 | L | Syracuse Central HS (NY) | 0 | Oneida HS (NY) | 7 | ? | |
| 1921 | W | Syracuse Central HS (NY) | 18 | Syracuse North HS (NY) | 0 | ? | |
| 1921 | L | Syracuse Central HS (NY) | 0 | Syracuse North HS (NY) | 10 | ? | |
| 1921 | T | Syracuse Central HS (NY) | 0 | Syracuse Vocational School (NY) | 0 | ? | |
| 1921 | W | Syracuse Central HS (NY) | 28 | Syracuse Vocational School (NY) | 7 | ? | |
| 1921 | T | Syracuse Central HS (NY) | 0 | Utica Free Academy (NY) | 0 | ? | |
| 1921 | L | Syracuse East HS (NY) | 0 | Sherrill HS (NY) | 55 | ? | |
| 1921 | L | Syracuse North HS (NY) | 7 | Auburn HS (NY) | 20 | ? | |
| 1921 | T | Syracuse North HS (NY) | 0 | Ithaca HS (NY) | 0 | ? | |
| 1921 | W | Syracuse North HS (NY) | 7 | Norwich HS (NY) | 6 | ? | |
| 1921 | L | Syracuse North HS (NY) | 0 | Syracuse Central HS (NY) | 18 | ? | |
| 1921 | W | Syracuse North HS (NY) | 10 | Syracuse Central HS (NY) | 0 | ? | |
| 1921 | L | Syracuse North HS (NY) | 0 | Syracuse Vocational School (NY) | 6 | ? | |
| 1921 | W | Syracuse North HS (NY) | 14 | Syracuse Vocational School (NY) | 0 | ? | |
| 1921 | W | Syracuse North HS (NY) | 13 | Utica Free Academy (NY) | 0 | ? | |
| 1921 | L | Syracuse Vocational School (NY) | 0 | Endicott Union HS (NY) | 30 | ? | |
| 1921 | L | Syracuse Vocational School (NY) | 0 | Oneida HS (NY) | 48 | ? | |
| 1921 | T | Syracuse Vocational School (NY) | 0 | Syracuse Central HS (NY) | 0 | ? | |
| 1921 | L | Syracuse Vocational School (NY) | 7 | Syracuse Central HS (NY) | 28 | ? | |
| 1921 | W | Syracuse Vocational School (NY) | 6 | Syracuse North HS (NY) | 0 | ? | |
| 1921 | L | Syracuse Vocational School (NY) | 0 | Syracuse North HS (NY) | 14 | ? | |
| 1921 | L | Taber Academy | 0 | Fall River Durfee HS (MA) | 7 | ? | |
| 1921 | L | Tabor (IA) | 0 | Nebraska-Omaha | 49 | Tabor, IA | |
| 1921 | W | Taft HS (CA) | 27 | Cal Poly-San Luis Obispo | 7 | Taft, CA | |
| 1921 | L | Taft HS (CA) | 0 | Fresno HS (CA) | 28 | ? | |
| 1921 | W | Taft School (CT) | 20 | Hotchkiss Academy (CT) | 6 | ? | |
| 1921 | T | Taft School (CT) | 0 | Pawling School (NY) | 0 | ? | |
| 1921 | W | Taft School (CT) | 16 | Pomfret School (CT) | 10 | ? | |
| 1921 | W | Talladega (AL) | 3 | Florida A&M | 0 | ? | |
| 1921 | W | Talladega (AL) | 27 | Miles (AL) | 0 | ? | |
| 1921 | W | Talladega (AL) | 21 | Mobile Tigers (AL) | 0 | ? | |
| 1921 | W | Talladega (AL) | 23 | Morris Brown (GA) | 13 | ? | |
| 1921 | T | Talladega (AL) | 7 | Wiley (TX) | 7 | ? | |
| 1921 | W | Talladega (AL) | 39 | Tuskegee (AL) | 7 | Birmingham, AL | Rickwood Field |
| 1921 | W | Talladega (AL) | 21 | Alabama St. | 20 | Montgomery, AL | |
| 1921 | W | Tamalpais HS (CA) | 14 | Napa HS (CA) | 7 | ? | |
| 1921 | W | Tamalpais HS (CA) | 14 | Petaluma HS (CA) | 7 | ? | |
| 1921 | T | Tamalpais HS (CA) | 0 | Piedmont HS (CA) | 0 | ? | |
| 1921 | L | Tamalpais HS (CA) | 0 | Potter School (CA) | 14 | ? | |
| 1921 | W | Tamalpais HS (CA) | 14 | San Francisco Lick Wilmerling HS (CA) | 7 | ? | |
| 1921 | T | Tamalpais HS (CA) | 0 | San Francisco Mission HS (CA) | 0 | ? | |
| 1921 | L | Tamalpais HS (CA) | 0 | Santa Rosa HS (CA) | 49 | ? | |
| 1921 | L | Tamalpais HS (CA) | 0 | Tamalpais Military Academy (CA) | 21 | ? | |
| 1921 | W | Tamalpais HS (CA) | 28 | Vallejo Moose HS | 0 | ? | |
| 1921 | W | Tamalpais HS (CA) | 27 | William Warren Military School (CA) | 7 | ? | |
| 1921 | L | Tamalpais Military Academy (CA) | 0 | San Francisco University School (CA) | 7 | ? | |
| 1921 | L | Tamalpais Military Academy (CA) | 0 | Santa Clara University HS (CA) | 39 | ? | |
| 1921 | W | Tamalpais Military Academy (CA) | 35 | Santa Rosa HS (CA) | 7 | ? | |
| 1921 | W | Tamalpais Military Academy (CA) | 21 | Tamalpais HS (CA) | 0 | ? | |
| 1921 | L | Tamaqua HS (PA) | 0 | Allentown HS (PA) | 55 | ? | |
| 1921 | L | Tamaqua HS (PA) | 0 | Bethlehem HS (PA) | 37 | ? | |
| 1921 | T | Tamaqua HS (PA) | 6 | Minersville HS (PA) | 6 | ? | |
| 1921 | L | Tampa HS (FL) | 0 | Jacksonville Duval HS (FL) | 74 | ? | |
| 1921 | L | Tarentum HS (PA) | 0 | Washington HS (PA) | 26 | ? | |
| 1921 | W | Tarkio (MO) | 41 | Central Missouri St. | 7 | Tarkio, MO | |
| 1921 | W | Tarkio (MO) | 7 | Missouri St. | 0 | Springfield, MO | 2-0? |
| 1921 | L | Tarkio (MO) | 3 | Nebraska-Omaha | 14 | Tarkio, MO | |
| 1921 | L | Tarkio (MO) | 0 | Parsons (IA) | 3 | Fairfield, IA | |
| 1921 | L | Tarkio (MO) | 3 | Truman St. (MO) | 34 | Tarkio, MO | |
| 1921 | L | Tarkio (MO) | 7 | Missouri Wesleyan | 23 | Cameron, MO | |
| 1921 | W | Tarkio (MO) | 23 | Northwest Missouri St. | 6 | ? | |
| 1921 | L | Tarkio (MO) | 0 | Nebraska Wesleyan | 35 | Lincoln, NE | |
| 1921 | L | Tarkio (MO) | 7 | William Jewell (MO) | 41 | Saint Joseph, MO | |
| 1921 | L | Taunton HS (MA) | 0 | Fall River Durfee HS (MA) | 21 | ? | |
| 1921 | L | Taunton HS (MA) | 0 | Fall River Durfee HS (MA) | 34 | ? | |
| 1921 | L | Taylorville HS (IL) | 0 | Danville HS (IL) | 34 | ? | |
| 1921 | L | Teachers College HS | 0 | Waterloo East HS (IA) | 10 | ? | |
| 1921 | W | Tecumseh HS (MI) | 7 | Addison HS (MI) | 0 | ? | |
| 1921 | W | Tecumseh HS (MI) | 19 | Blissfield HS (MI) | 7 | ? | |
| 1921 | W | Tecumseh HS (MI) | 27 | Chelsea HS (MI) | 0 | ? | |
| 1921 | W | Tecumseh HS (MI) | 88 | Chelsea HS (MI) | 0 | ? | |
| 1921 | L | Tecumseh HS (MI) | 0 | Clinton HS (MI) | 10 | ? | |
| 1921 | W | Tecumseh HS (MI) | 47 | Dundee HS (MI) | 0 | ? | |
| 1921 | W | Tecumseh HS (MI) | 12 | Hudson HS (MI) | 0 | ? | |
| 1921 | W | Tecumseh HS (MI) | 6 | Morenci HS (MI) | 0 | ? | |
| 1921 | L | Tennessee | 3 | Dartmouth (NH) | 14 | Hanover, NH | |
| 1921 | W | Tennessee | 27 | Emory & Henry (VA) | 0 | Knoxville, TN | |
| 1921 | W | Tennessee | 9 | Florida | 0 | Knoxville, TN | |
| 1921 | T | Tennessee | 0 | Kentucky | 0 | Lexington, KY | |
| 1921 | L | Tennessee | 0 | Vanderbilt (TN) | 14 | Nashville, TN | |
| 1921 | W | Tennessee | 7 | Maryville (TN) | 0 | Knoxville, TN | |
| 1921 | W | Tennessee | 14 | Mississippi St. | 7 | Memphis, TN | |
| 1921 | W | Tennessee | 21 | Tennessee-Chattanooga | 0 | Knoxville, TN | |
| 1921 | W | Tennessee | 21 | Sewanee (TN) | 0 | Knoxville, TN | |
| 1921 | T | Tennessee JV | 0 | Tusculum (TN) | 0 | ? | Score unknown |
| 1921 | W | Tennessee Medical College | 19 | Lyon College (AR) | 0 | ? | |
| 1921 | W | Tennessee Medical College | 20 | Middle Tennessee St. | 0 | Memphis, TN | |
| 1921 | W | Tennessee Medical College | 14 | Millsaps (MS) | 0 | ? | |
| 1921 | W | Tennessee Medical College | 24 | Mississippi | 6 | Memphis, TN | |
| 1921 | W | Tennessee Medical College | 14 | Union (TN) | 0 | Memphis, TN | |
| 1921 | W | Tennessee Medical College | 28 | Central Arkansas | 0 | Memphis, TN | |
| 1921 | T | Tennessee Medical College JV | 7 | Memphis (TN) | 7 | Memphis, TN | |
| 1921 | W | Tennessee Military Institute | 13 | Baylor Military Academy (TN) | 6 | ? | |
| 1921 | L | Tennessee Military Institute | 0 | Benton HS (TN) | 19 | ? | |
| 1921 | L | Tennessee Military Institute | 7 | Bradley County HS (TN) | 23 | ? | |
| 1921 | W | Tennessee Military Institute | 23 | Fitzgerald & Clark (TN) | 2 | ? | |
| 1921 | W | Tennessee Military Institute | 7 | Knox County Central HS (TN) | 0 | ? | |
| 1921 | W | Tennessee Military Institute | 7 | Knoxville HS (TN) | 0 | ? | |
| 1921 | W | Tennessee Military Institute | 27 | Sewanee Military Academy (TN) | 6 | ? | |
| 1921 | W | Tennessee Military Institute | 7 | Tennessee Wesleyan | 0 | ? | |
| 1921 | L | Tennessee St. | 0 | Lane (TN) | 7 | ? | |
| 1921 | L | Tennessee Wesleyan | 0 | Carson-Newman (TN) | 20 | ? | |
| 1921 | L | Tennessee Wesleyan | 0 | Tennessee Military Institute | 7 | ? | |
| 1921 | L | Tennessee Wesleyan | 0 | Tennessee-Chattanooga | 20 | Athens, TN | |
| 1921 | T | Tennessee Wesleyan | 0 | Tusculum (TN) | 0 | ? | Score unknown |
| 1921 | W | Tennessee-Chattanooga | 53 | Bryson (TN) | 0 | Chattanooga, TN | |
| 1921 | W | Tennessee-Chattanooga | 31 | Georgetown (KY) | 0 | Chattanooga, TN | |
| 1921 | L | Tennessee-Chattanooga | 0 | Maryville (TN) | 34 | Chattanooga, TN | |
| 1921 | L | Tennessee-Chattanooga | 0 | Mercer (GA) | 18 | Macon, GA | |
| 1921 | L | Tennessee-Chattanooga | 0 | Oglethorpe (GA) | 7 | Atlanta, GA | |
| 1921 | W | Tennessee-Chattanooga | 26 | Samford (AL) | 3 | Gadsden, AL | |
| 1921 | W | Tennessee-Chattanooga | 20 | Tennessee Wesleyan | 0 | Athens, TN | |
| 1921 | L | Tennessee-Chattanooga | 0 | Sewanee (TN) | 47 | Chattanooga, TN | |
| 1921 | L | Tennessee-Chattanooga | 0 | Tennessee | 21 | Knoxville, TN | |
| 1921 | L | Tennessee-Chattanooga | 7 | Birmingham-Southern (AL) | 14 | Birmingham, AL | |
| 1921 | L | Terrell HS (TX) | 0 | Terrill Prep School (TX) | 54 | ? | |
| 1921 | W | Terrill Prep School (TX) | 28 | Chickasha HS (OK) | 7 | ? | |
| 1921 | W | Terrill Prep School (TX) | 20 | Decatur Baptist College (TX) | 0 | ? | |
| 1921 | W | Terrill Prep School (TX) | 13 | Fort Worth HS (TX) | 0 | ? | |
| 1921 | W | Terrill Prep School (TX) | 91 | Meridian College (TX) | 3 | ? | |
| 1921 | W | Terrill Prep School (TX) | 7 | Powell University Training School (TX) | 0 | ? | |
| 1921 | L | Terrill Prep School (TX) | 0 | Rice Freshmen (TX) | 28 | ? | |
| 1921 | W | Terrill Prep School (TX) | 21 | Southwestern Military Academy | 7 | ? | |
| 1921 | W | Terrill Prep School (TX) | 54 | Terrell HS (TX) | 0 | ? | |
| 1921 | L | Texarkana HS (AR) | 13 | Little Rock HS (AR) | 21 | ? | |
| 1921 | L | Texarkana HS (AR) | 0 | Pine Bluff HS (AR) | 41 | ? | |
| 1921 | W | Texas | 21 | Howard Payne (TX) | 0 | Austin, TX | |
| 1921 | W | Texas | 56 | Rice (TX) | 0 | Austin, TX | |
| 1921 | T | Texas | 0 | Texas A&M | 0 | College Station, TX | |
| 1921 | L | Texas | 0 | Vanderbilt (TN) | 20 | Dallas, TX | |
| 1921 | W | Texas | 33 | Saint Edward's (TX) | 0 | Austin, TX | |
| 1921 | W | Texas | 44 | Southwestern (TX) | 0 | Austin, TX | |
| 1921 | W | Texas | 60 | Austin (TX) | 0 | Austin, TX | |
| 1921 | W | Texas | 54 | Mississippi St. | 7 | Austin, TX | |
| 1921 | W | Texas A&M | 17 | Arizona | 13 | College Station, TX | |
| 1921 | W | Texas A&M | 14 | Howard Payne (TX) | 7 | College Station, TX | |
| 1921 | L | Texas A&M | 0 | Louisiana St. | 6 | Baton Rouge, LA | |
| 1921 | W | Texas A&M | 23 | Oklahoma St. | 7 | College Station, TX | |
| 1921 | T | Texas A&M | 0 | Texas | 0 | College Station, TX | |
| 1921 | W | Texas A&M | 14 | Baylor (TX) | 3 | Waco, TX | |
| 1921 | T | Texas A&M | 7 | Rice (TX) | 7 | Houston, TX | |
| 1921 | W | Texas A&M | 13 | Southern Methodist (TX) | 0 | Dallas, TX | |
| 1921 | T | Texas A&M B Team | 7 | Sam Houston St. (TX) | 7 | Huntsville, TX | |
| 1921 | T | Texas A&M-Commerce | 0 | College of Marshall (TX) | 0 | Commerce, TX | |
| 1921 | L | Texas A&M-Commerce | 0 | Sam Houston St. (TX) | 7 | Commerce, TX | |
| 1921 | W | Texas A&M-Commerce | 14 | Southeastern Oklahoma St. | 7 | Commerce, TX | |
| 1921 | L | Texas A&M-Commerce | 0 | Texas St. | 26 | Commerce, TX | |
| 1921 | W | Texas A&M-Commerce | 9 | Texas-Arlington | 0 | Arlington, TX | |
| 1921 | W | Texas A&M-Commerce | 13 | Wesley College (TX) | 7 | Greenville, TX | |
| 1921 | L | Texas A&M-Commerce | 0 | Burleson College (TX) | 2 | Greenville, TX | |
| 1921 | L | Texas A&M-Commerce | 3 | Dallas (TX) | 6 | Commerce, TX | |
| 1921 | L | Texas AC | 0 | New Mexico St. | 35 | Las Cruces, NM | Exhibition Game |
| 1921 | W | Texas Christian | 19 | Arkansas | 14 | Fort Worth, TX | |
| 1921 | L | Texas Christian | 0 | Haskell Indian Nations (KS) | 14 | Fort Worth, TX | |
| 1921 | T | Texas Christian | 0 | Phillips (OK) | 0 | Enid, OK | |
| 1921 | W | Texas Christian | 19 | Trinity (TX) | 3 | Fort Worth, TX | |
| 1921 | W | Texas Christian | 16 | Tulsa (OK) | 0 | Fort Worth, TX | |
| 1921 | W | Texas Christian | 30 | West Texas A&M | 0 | Canyon, TX | |
| 1921 | L | Texas Christian | 7 | Centre (KY) | 63 | Fort Worth, TX | Fort Worth Classic |
| 1921 | L | Texas Christian | 7 | Hardin-Simmons (TX) | 10 | Abilene, TX | |
| 1921 | W | Texas Christian | 7 | Kirksville Osteopath (MO) | 0 | Fort Worth, TX | |
| 1921 | L | Texas Christian | 21 | Oklahoma St. | 28 | Stillwater, OK | |
| 1921 | W | Texas Christian | 13 | Southern Methodist (TX) | 6 | Dallas, TX | |
| 1921 | W | Texas College | 6 | Jarvis Christian (TX) | 0 | ? | |
| 1921 | W | Texas Freshmen | 6 | College of Marshall (TX) | 0 | ? | Texas Freshmen won - score unknown |
| 1921 | W | Texas Freshmen | 72 | San Marcos Baptist (TX) | 0 | ? | |
| 1921 | W | Texas Freshmen | 28 | Wesley College (TX) | 0 | ? | |
| 1921 | W | Texas Lutheran | 1 | Floresville HS (TX) | 0 | ? | Floresville Forfeits |
| 1921 | W | Texas Lutheran | 6 | Gonzales HS (TX) | 0 | ? | |
| 1921 | W | Texas Lutheran | 47 | Seguin HS (TX) | 0 | ? | |
| 1921 | T | Texas Military College | 0 | Wesley College (TX) | 0 | ? | |
| 1921 | W | Texas Military College | 7 | Burleson College (TX) | 0 | Greenville, TX | |
| 1921 | W | Texas St. | 28 | Daniel Baker (TX) | 3 | San Marcos, TX | |
| 1921 | W | Texas St. | 14 | North Texas | 0 | ? | |
| 1921 | W | Texas St. | 31 | Saint Edward's (TX) | 7 | San Marcos, TX | |
| 1921 | W | Texas St. | 14 | Sam Houston St. (TX) | 13 | Huntsville, TX | |
| 1921 | W | Texas St. | 62 | San Marcos Baptist (TX) | 3 | ? | |
| 1921 | W | Texas St. | 26 | Texas A&M-Commerce | 0 | Commerce, TX | |
| 1921 | W | Texas St. | 10 | Southwestern (TX) | 0 | Georgetown, TX | |
| 1921 | W | Texas-Arlington | 21 | Burleson College (TX) | 20 | Arlington, TX | |
| 1921 | L | Texas-Arlington | 0 | Dallas (TX) | 20 | ? | |
| 1921 | T | Texas-Arlington | 7 | John Tarleton College (TX) | 7 | ? | |
| 1921 | L | Texas-Arlington | 6 | North Texas | 41 | ? | |
| 1921 | L | Texas-Arlington | 0 | Texas A&M-Commerce | 9 | Arlington, TX | |
| 1921 | W | Texas-Arlington | 28 | Wesley College (TX) | 0 | ? | |
| 1921 | L | Texas-El Paso | 0 | Arizona | 74 | Tucson, AZ | |
| 1921 | L | Texas-El Paso | 0 | Calumus Club | 21 | El Paso, TX | |
| 1921 | L | Texas-El Paso | 7 | Fort Bliss All-Stars (TX) | 14 | El Paso, TX | |
| 1921 | L | Texas-El Paso | 7 | New Mexico Military Institute | 27 | Roswell, NM | |
| 1921 | L | Texas-El Paso | 0 | New Mexico St. | 13 | El Paso, TX | |
| 1921 | W | Thayer Academy (MA) | 35 | Braintree HS (MA) | 0 | ? | |
| 1921 | L | Thayer Academy (MA) | 0 | Country Day School (MA) | 27 | ? | |
| 1921 | L | Thayer Academy (MA) | 0 | Lynn Classical HS (MA) | 28 | ? | |
| 1921 | T | Thayer Academy (MA) | 0 | Milton HS (MA) | 0 | ? | |
| 1921 | L | Thayer Academy (MA) | 6 | Noble & Greenough (MA) | 7 | ? | |
| 1921 | L | Thayer Academy (MA) | 7 | Quincy HS (MA) | 27 | ? | |
| 1921 | W | Thayer Academy (MA) | 3 | Roxbury Latin School (MA) | 0 | ? | |
| 1921 | L | Thayer Academy (MA) | 0 | Saint George Academy | 3 | ? | |
| 1921 | L | The Dalles HS (OR) | 0 | Pendleton HS (OR) | 21 | ? | |
| 1921 | L | Thief River Falls HS (MN) | 0 | Bemidji HS (MN) | 19 | ? | |
| 1921 | W | Thief River Falls HS (MN) | 19 | Cavalier HS (ND) | 0 | ? | |
| 1921 | L | Thief River Falls HS (MN) | 0 | Crookston HS (MN) | 27 | ? | |
| 1921 | W | Thief River Falls HS (MN) | 13 | East Grand Forks HS (MN) | 0 | ? | |
| 1921 | W | Thief River Falls HS (MN) | 32 | Fosston HS (MN) | 7 | ? | |
| 1921 | W | Thief River Falls HS (MN) | 31 | Red Lake Falls HS (MN) | 13 | ? | |
| 1921 | T | Thief River Falls HS (MN) | 0 | Stephen HS (MN) | 0 | ? | |
| 1921 | W | Thiel (PA) | 35 | Ashland (OH) | 0 | ? | |
| 1921 | L | Thiel (PA) | 0 | Carnegie Mellon (PA) | 42 | Pittsburgh, PA | |
| 1921 | W | Thiel (PA) | 26 | Duquesne (PA) | 0 | Greenville, PA | |
| 1921 | W | Thiel (PA) | 6 | Juniata (PA) | 0 | Huntingdon, PA | |
| 1921 | L | Thiel (PA) | 0 | Marietta (OH) | 22 | Marietta, OH | |
| 1921 | L | Thiel (PA) | 0 | Grove City (PA) | 6 | Greenville, PA | |
| 1921 | W | Thiel (PA) | 12 | Susquehanna (PA) | 0 | Greenville, PA | |
| 1921 | T | Thiel (PA) | 0 | Buffalo (NY) | 0 | Buffalo, NY | |
| 1921 | W | Thiel (PA) | 13 | Alfred (NY) | 0 | Alfred, NY | |
| 1921 | L | Thomas HS (WV) | 0 | Keyser Prep School (WV) | 42 | ? | |
| 1921 | L | Thomas HS (WV) | 7 | Keyser Prep School (WV) | 27 | ? | |
| 1921 | L | Thomas HS (WV) | 0 | Parsons HS (WV) | 37 | ? | |
| 1921 | L | Thomas HS (WV) | 0 | Parsons HS (WV) | 63 | ? | |
| 1921 | L | Thomaston HS (AL) | 0 | Jackson Agricultural School (AL) | 26 | ? | |
| 1921 | W | Thomasville HS (AL) | 13 | Jackson Agricultural School (AL) | 0 | ? | |
| 1921 | L | Thornton HS (IL) | 6 | Bloom Township HS (IL) | 7 | ? | |
| 1921 | L | Thornton HS (IL) | 0 | Chicago Bowen HS (IL) | 41 | ? | |
| 1921 | L | Thornton HS (IL) | 0 | Deerfield Shields HS (IL) | 46 | ? | |
| 1921 | W | Thornton HS (IL) | 10 | Des Plaines HS (IL) | 7 | ? | |
| 1921 | L | Thornton HS (IL) | 0 | Downers Grove HS (IL) | 2 | ? | |
| 1921 | L | Thornton HS (IL) | 0 | Evanston HS (IL) | 34 | ? | |
| 1921 | L | Thornton HS (IL) | 0 | La Grange HS (IL) | 84 | ? | |
| 1921 | L | Thornton HS (IL) | 0 | Proviso Township HS (IL) | 33 | ? | |
| 1921 | W | Thornton HS (IL) | 14 | Riverside HS (IL) | 7 | ? | |
| 1921 | L | Tiffin HS (OH) | 7 | Sandusky HS (OH) | 13 | ? | |
| 1921 | L | Tiffin HS (OH) | 0 | Toledo Waite HS (OH) | 114 | ? | |
| 1921 | L | Tiffin Junior Order Home (OH) | 0 | Ashland (OH) | 8 | Ashland, OH | Heidelberg JV? |
| 1921 | L | Tilden HS (WI) | 0 | Chicago Bowen HS (IL) | 3 | ? | |
| 1921 | L | Tilden HS (WI) | 0 | Chicago Bowen HS (IL) | 9 | ? | |
| 1921 | L | Tillamook HS (OR) | 0 | Astoria HS (OR) | 13 | ? | |
| 1921 | W | Tilton Seminary (NH) | 12 | Brewster Academy (NH) | 0 | ? | |
| 1921 | L | Tilton Seminary (NH) | 0 | Colby Academy (NH) | 6 | ? | |
| 1921 | W | Tilton Seminary (NH) | 6 | Concord HS (NH) | 0 | ? | |
| 1921 | W | Tilton Seminary (NH) | 19 | Holderness HS (NH) | 0 | ? | |
| 1921 | T | Tilton Seminary (NH) | 0 | Laconia HS (NH) | 0 | ? | |
| 1921 | W | Tilton Seminary (NH) | 6 | New Hampshire Freshmen | 0 | ? | |
| 1921 | W | Tilton Seminary (NH) | 14 | New Hampton School (NH) | 7 | ? | |
| 1921 | L | Timmonsville HS (SC) | 0 | Charleston HS (SC) | 33 | ? | |
| 1921 | L | Toccoa HS (GA) | 0 | Athens HS (GA) | 55 | ? | |
| 1921 | L | Toledo (OH) | 0 | Adrian (MI) | 1 | Adrian, MI | Toledo Forfeits |
| 1921 | L | Toledo (OH) | 7 | Bowling Green (OH) | 20 | Toledo, OH | |
| 1921 | L | Toledo (OH) | 0 | Cincinnati (OH) | 20 | Cincinnati, OH | |
| 1921 | W | Toledo (OH) | 40 | Defiance (OH) | 0 | Toledo, OH | |
| 1921 | L | Toledo (OH) | 0 | Wayne St. (MI) | 13 | Toledo, OH | |
| 1921 | W | Toledo (OH) | 0 | Baldwin-Wallace (OH) | 35 | Toledo, OH | Baldwin-Wallace Forfeits |
| 1921 | W | Toledo (OH) | 46 | Findlay (OH) | 0 | Findlay, OH | |
| 1921 | L | Toledo (OH) | 0 | Bluffton (OH) | 14 | Bluffton, OH | |
| 1921 | L | Toledo Central HS (OH) | 0 | Fostoria HS (OH) | 49 | ? | |
| 1921 | L | Toledo Scott HS (OH) | 7 | Cleveland East Tech HS (OH) | 14 | ? | |
| 1921 | W | Toledo Scott HS (OH) | 45 | Columbus East HS (OH) | 0 | ? | |
| 1921 | W | Toledo Scott HS (OH) | 19 | Flint Central HS (MI) | 0 | ? | |
| 1921 | W | Toledo Scott HS (OH) | 69 | Fort Wayne HS (IN) | 0 | ? | |
| 1921 | W | Toledo Scott HS (OH) | 34 | Johnstown HS (PA) | 0 | ? | |
| 1921 | W | Toledo Scott HS (OH) | 87 | Mount Vernon HS (OH) | 0 | ? | |
| 1921 | L | Toledo Scott HS (OH) | 0 | Toledo Waite HS (OH) | 42 | ? | |
| 1921 | W | Toledo Scott HS (OH) | 39 | Wheaton HS (IL) | 0 | ? | |
| 1921 | W | Toledo Scott HS (OH) | 74 | Wooster HS (OH) | 0 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 162 | Ada HS (OH) | 0 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 95 | Akron Central HS (OH) | 0 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 48 | Bluffton HS (OH) | 0 | ? | |
| 1921 | L | Toledo Waite HS (OH) | 7 | Dayton Steele HS (OH) | 14 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 13 | Dayton Stivers Manual Training HS (OH) | 3 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 61 | Detroit Western HS (MI) | 0 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 84 | Forest HS | 0 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 27 | Lakewood HS (OH) | 14 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 13 | Malden HS (MA) | 0 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 114 | Tiffin HS (OH) | 0 | ? | |
| 1921 | W | Toledo Waite HS (OH) | 42 | Toledo Scott HS (OH) | 0 | ? | |
| 1921 | W | Tome Institute (MD) | 20 | Army & Navy Prep School (DC) | 0 | ? | |
| 1921 | L | Tome Institute (MD) | 0 | Gilman Country School (MD) | 66 | ? | |
| 1921 | L | Tome Institute (MD) | 7 | Hill School (PA) | 14 | ? | |
| 1921 | L | Tome Institute (MD) | 0 | Lawrenceville School (NJ) | 35 | ? | |
| 1921 | W | Tome Institute (MD) | 12 | Philadelphia Northeast HS (PA) | 0 | ? | |
| 1921 | W | Tome Institute (MD) | 25 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | L | Tome Institute (MD) | 0 | Wilmington HS (DE) | 13 | ? | |
| 1921 | T | Toms River HS (NJ) | 0 | Clinton HS (NJ) | 0 | ? | |
| 1921 | L | Toms River HS (NJ) | 0 | Lakewood HS (NJ) | 54 | ? | |
| 1921 | L | Toms River HS (NJ) | 0 | Newman School (NJ) | 27 | ? | |
| 1921 | L | Toms River HS (NJ) | 0 | Princeton HS (NJ) | 33 | ? | |
| 1921 | L | Toms River HS (NJ) | 0 | Red Bank HS (NJ) | 24 | ? | |
| 1921 | W | Tonawanda HS (NY) | 12 | Batavia HS (NY) | 0 | ? | |
| 1921 | W | Tonawanda HS (NY) | 7 | Buffalo Lafayette HS (NY) | 0 | ? | |
| 1921 | W | Tonawanda HS (NY) | 14 | Buffalo South Park HS (NY) | 0 | ? | |
| 1921 | W | Tonawanda HS (NY) | 41 | Dunkirk HS (NY) | 0 | ? | |
| 1921 | L | Tonawanda HS (NY) | 16 | Erie HS (PA) | 27 | ? | |
| 1921 | W | Tonawanda HS (NY) | 27 | Hutchinson Central HS (NY) | 6 | ? | |
| 1921 | W | Tonawanda HS (NY) | 28 | Niagara Falls HS (NY) | 0 | ? | |
| 1921 | W | Tonawanda HS (NY) | 22 | North Tonawanda HS (NY) | 0 | ? | |
| 1921 | L | Tooele HS (UT) | 7 | Ogden HS (UT) | 20 | ? | |
| 1921 | L | Toronto | 0 | Clark HS (SD) | 1 | ? | Toronto Forfeits |
| 1921 | T | Toronto HS (OH) | 6 | Richland District HS (WV) | 6 | ? | |
| 1921 | W | Toronto HS (OH) | 19 | Richland District HS (WV) | 9 | ? | |
| 1921 | L | Torpedo Station | 0 | Western Washington | 28 | Bellingham, WA | |
| 1921 | L | Tougaloo (MS) | 0 | Rust (MS) | 19 | ? | |
| 1921 | W | Towanda HS (PA) | 12 | Athens HS (PA) | 0 | ? | |
| 1921 | W | Towanda HS (PA) | 7 | Athens HS (PA) | 0 | ? | |
| 1921 | L | Tracy HS (MN) | 0 | Pipestone HS (MN) | 6 | ? | |
| 1921 | L | Transylvania (KY) | 0 | Centre (KY) | 98 | Lexington, KY | |
| 1921 | W | Transylvania (KY) | 14 | Fort Knox (KY) | 7 | ? | |
| 1921 | W | Transylvania (KY) | 14 | Georgetown (KY) | 6 | Georgetown, KY | |
| 1921 | W | Transylvania (KY) | 37 | Kentucky Wesleyan | 0 | Winchester, KY | |
| 1921 | L | Transylvania (KY) | 0 | Marshall (WV) | 13 | Lexington, KY | |
| 1921 | W | Transylvania (KY) | 7 | Louisville (KY) | 0 | Lexington, KY | |
| 1921 | L | Transylvania (KY) | 0 | DePauw (IN) | 28 | Greencastle, IN | |
| 1921 | L | Transylvania (KY) | 0 | Franklin (IN) | 35 | Franklin, IN | |
| 1921 | W | Traverse City HS (MI) | 24 | Ferris St. (MI) | 0 | Traverse City, MI | |
| 1921 | L | Traverse City HS (MI) | 0 | Muskegon HS (MI) | 79 | ? | |
| 1921 | L | Traverse City HS (MI) | 0 | Saginaw Arthur Hill HS (MI) | 24 | ? | |
| 1921 | W | Tredyffun-Easttown HS (PA) | 14 | Abington HS (PA) | 7 | ? | |
| 1921 | W | Tredyffun-Easttown HS (PA) | 13 | Lower Merion HS (PA) | 0 | ? | |
| 1921 | L | Tredyffun-Easttown HS (PA) | 7 | Philadelphia West Catholic HS (PA) | 28 | ? | |
| 1921 | L | Tredyffun-Easttown HS (PA) | 0 | Radnor HS (PA) | 20 | ? | |
| 1921 | T | Trenton HS (NJ) | 7 | Asbury Park HS (NJ) | 7 | ? | |
| 1921 | W | Trenton HS (NJ) | 27 | Atlantic City HS (NJ) | 0 | ? | |
| 1921 | W | Trenton HS (NJ) | 13 | Bordentown Military Institute (NJ) | 7 | Trenton, NJ | Chambers Street Field |
| 1921 | W | Trenton HS (NJ) | 11 | Camden HS (NJ) | 7 | ? | |
| 1921 | W | Trenton HS (NJ) | 63 | Cathedral HS | 6 | ? | |
| 1921 | T | Trenton HS (NJ) | 7 | East Orange HS (NJ) | 7 | ? | |
| 1921 | W | Trenton HS (NJ) | 26 | Lambertville HS (NJ) | 0 | ? | |
| 1921 | W | Trenton HS (NJ) | 12 | Long Branch Chattle HS (NJ) | 0 | ? | |
| 1921 | L | Trenton HS (NJ) | 0 | Neptune HS (NJ) | 7 | ? | |
| 1921 | W | Trenton HS (NJ) | 7 | Rutgers Prep School (NJ) | 6 | ? | |
| 1921 | W | Trenton HS (NJ) | 26 | Union City Emerson HS (NJ) | 0 | ? | |
| 1921 | L | Triadelphia HS (WV) | 0 | Bellaire HS (OH) | 48 | ? | |
| 1921 | W | Triadelphia HS (WV) | 6 | Cameron HS (WV) | 0 | ? | |
| 1921 | W | Triadelphia HS (WV) | 10 | Chester HS (WV) | 7 | ? | |
| 1921 | W | Triadelphia HS (WV) | 7 | Flushing HS (OH) | 0 | ? | |
| 1921 | L | Triadelphia HS (WV) | 0 | Follansbee HS (WV) | 41 | ? | |
| 1921 | L | Triadelphia HS (WV) | 0 | Linsly Military Institute (WV) | 23 | ? | |
| 1921 | L | Triadelphia HS (WV) | 0 | Mannington HS (WV) | 42 | ? | |
| 1921 | W | Triadelphia HS (WV) | 6 | Moundsville HS (WV) | 0 | ? | |
| 1921 | T | Triadelphia HS (WV) | 0 | New Martinsville HS (WV) | 0 | ? | |
| 1921 | T | Triadelphia HS (WV) | 0 | Richland District HS (WV) | 0 | ? | |
| 1921 | W | Triadelphia HS (WV) | 14 | Triadelphia HS Alumni (WV) | 13 | ? | |
| 1921 | T | Triadelphia HS (WV) | 0 | Warwood HS (WV) | 0 | ? | |
| 1921 | L | Triadelphia HS Alumni (WV) | 13 | Triadelphia HS (WV) | 14 | ? | |
| 1921 | L | Trinidad HS (CO) | 0 | Canon City HS (CO) | 34 | ? | |
| 1921 | T | Trinidad HS (CO) | 6 | Fort Lyon HS (CO) | 6 | ? | |
| 1921 | W | Trinidad HS (CO) | 9 | La Junta HS (CO) | 6 | ? | |
| 1921 | T | Trinidad HS (CO) | 6 | Las Animas HS (CO) | 6 | ? | |
| 1921 | W | Trinidad HS (CO) | 16 | Pueblo Centennial HS (CO) | 14 | ? | |
| 1921 | L | Trinidad HS (CO) | 0 | Pueblo Central HS (CO) | 6 | ? | |
| 1921 | W | Trinidad HS (CO) | 27 | Raton HS (NM) | 3 | ? | |
| 1921 | L | Trinity (CT) | 0 | Boston (MA) | 14 | Hartford, CT | |
| 1921 | L | Trinity (CT) | 0 | Bowdoin (ME) | 7 | Hartford, CT | |
| 1921 | W | Trinity (CT) | 6 | Stevens Tech (NJ) | 0 | Hoboken, NJ | |
| 1921 | W | Trinity (CT) | 6 | Worcester Tech (MA) | 0 | Hartford, CT | |
| 1921 | T | Trinity (CT) | 0 | Connecticut | 0 | Storrs, CT | |
| 1921 | L | Trinity (CT) | 0 | New York (NY) | 28 | New York, NY | Ohio Field |
| 1921 | L | Trinity (CT) | 0 | Haverford (PA) | 6 | Haverford, PA | |
| 1921 | L | Trinity (IA) | 0 | Buena Vista (IA) | 7 | Storm Lake, IA | |
| 1921 | W | Trinity (IA) | 1 | Columbus (SD) | 0 | ? | Columbus Forfeits |
| 1921 | L | Trinity (IA) | 0 | Doane (NE) | 17 | ? | |
| 1921 | L | Trinity (IA) | 0 | Luther (IA) | 35 | ? | |
| 1921 | W | Trinity (IA) | 10 | Nebraska-Omaha | 0 | Omaha, NE | |
| 1921 | L | Trinity (IA) | 0 | Si Tanka (SD) | 13 | ? | |
| 1921 | L | Trinity (IA) | 0 | Buena Vista (IA) | 9 | Sioux City, IA | |
| 1921 | L | Trinity (IA) | 0 | Westmar (IA) | 10 | LeMars, IA | |
| 1921 | W | Trinity (TX) | 7 | Austin (TX) | 3 | Sherman, TX | |
| 1921 | L | Trinity (TX) | 0 | Hardin-Simmons (TX) | 7 | Waxahachie, TX | |
| 1921 | L | Trinity (TX) | 0 | Howard Payne (TX) | 29 | Brownwood, TX | |
| 1921 | L | Trinity (TX) | 14 | Rice (TX) | 28 | San Antonio, TX | |
| 1921 | L | Trinity (TX) | 3 | Texas Christian | 19 | Fort Worth, TX | |
| 1921 | W | Trinity (TX) | 35 | Wesley College (TX) | 0 | ? | |
| 1921 | W | Trinity (TX) | 17 | Dallas (TX) | 0 | Waxahachie, TX | |
| 1921 | W | Trinity (TX) | 7 | Daniel Baker (TX) | 0 | San Antonio, TX | |
| 1921 | T | Trinity Freshmen (CT) | 7 | Hotchkiss Academy (CT) | 7 | ? | |
| 1921 | L | Trinity Park HS | 6 | Chapel Hill HS (NC) | 7 | ? | |
| 1921 | L | Trinity Park HS | 7 | Chapel Hill HS (NC) | 9 | ? | |
| 1921 | L | Trinity School (NY) | 6 | Barnard School (NY) | 20 | ? | |
| 1921 | L | Troy (AL) | 0 | Enterprise HS (AL) | 33 | Troy, AL | |
| 1921 | L | Troy (AL) | 0 | Luverne HS (AL) | 30 | Luverne, AL | |
| 1921 | L | Troy (AL) | 0 | Luverne HS (AL) | 34 | Troy, AL | |
| 1921 | L | Troy (AL) | 0 | Montgomery Sidney Lanier HS (AL) | 62 | Montgomery, AL | |
| 1921 | L | Troy (AL) | 7 | Ramer HS (AL) | 13 | Troy, AL | |
| 1921 | W | Troy (AL) | 12 | Repton HS (AL) | 6 | Troy, AL | |
| 1921 | L | Troy (AL) | 0 | Dothan HS (AL) | 41 | Dothan, AL | |
| 1921 | L | Troy (AL) | 0 | Ramer HS (AL) | 65 | Ramer, AL | |
| 1921 | L | Troy HS (NY) | 0 | Albany HS (NY) | 21 | ? | |
| 1921 | L | Troy HS (NY) | 13 | Gloversville HS (NY) | 36 | ? | |
| 1921 | L | Troy HS (NY) | 0 | Saratoga Springs HS (NY) | 7 | ? | |
| 1921 | W | Troy HS (OH) | 13 | Springfield HS (OH) | 6 | ? | |
| 1921 | L | Troy HS (OH) | 0 | Xenia Central HS (OH) | 16 | ? | |
| 1921 | W | Truman St. (MO) | 7 | Central Missouri St. | 0 | Kirksville, MO | |
| 1921 | L | Truman St. (MO) | 6 | Kirksville Osteopath (MO) | 28 | Kirksville, MO | |
| 1921 | W | Truman St. (MO) | 20 | Missouri Valley | 0 | Kirksville, MO | |
| 1921 | W | Truman St. (MO) | 13 | Northwest Missouri St. | 0 | Maryville, MO | |
| 1921 | W | Truman St. (MO) | 34 | Tarkio (MO) | 3 | Tarkio, MO | |
| 1921 | W | Truman St. (MO) | 6 | Westminster (MO) | 0 | Fulton, MO | |
| 1921 | W | Truman St. (MO) | 20 | Culver-Stockton (MO) | 0 | Kirksville, MO | |
| 1921 | W | Truman St. (MO) | 16 | Illinois College | 13 | Kirksville, MO | |
| 1921 | L | Truman St. (MO) | 7 | Central Methodist (MO) | 13 | Fayette, MO | |
| 1921 | L | Tufts (MA) | 0 | Massachusetts | 14 | Amherst, MA | |
| 1921 | W | Tufts (MA) | 6 | Norwich (VT) | 0 | Medford, MA | |
| 1921 | L | Tufts (MA) | 0 | Vermont | 6 | Medford, MA | |
| 1921 | T | Tufts (MA) | 14 | Wesleyan (CT) | 14 | Middletown, CT | |
| 1921 | L | Tufts (MA) | 10 | Bates (ME) | 14 | Medford, MA | |
| 1921 | L | Tufts (MA) | 7 | Boston (MA) | 8 | Medford, MA | |
| 1921 | T | Tufts (MA) | 0 | Amherst (MA) | 0 | Amherst, MA | |
| 1921 | L | Tufts (MA) | 0 | Bowdoin (ME) | 20 | Brunswick, ME | |
| 1921 | T | Tufts Freshmen (MA) | 7 | Pomfret School (CT) | 7 | ? | |
| 1921 | L | Tufts Freshmen (MA) | 0 | Saint John's Prep (MA) | 7 | ? | |
| 1921 | L | Tulalip Independents (WA) | 7 | Granite Falls HS (WA) | 41 | ? | |
| 1921 | L | Tulane (LA) | 0 | Centre (KY) | 21 | New Orleans, LA | |
| 1921 | L | Tulane (LA) | 10 | Detroit (MI) | 14 | Detroit, MI | |
| 1921 | W | Tulane (LA) | 21 | Louisiana St. | 0 | New Orleans, LA | |
| 1921 | W | Tulane (LA) | 7 | Mississippi St. | 0 | New Orleans, LA | |
| 1921 | W | Tulane (LA) | 7 | Rice (TX) | 6 | Houston, TX | |
| 1921 | L | Tulane (LA) | 0 | Mississippi College | 14 | New Orleans, LA | |
| 1921 | L | Tulane (LA) | 7 | Alabama | 14 | New Orleans, LA | |
| 1921 | L | Tulane (LA) | 0 | Auburn (AL) | 14 | New Orleans, LA | |
| 1921 | W | Tulane (LA) | 26 | Mississippi | 0 | New Orleans, LA | |
| 1921 | L | Tulane (LA) | 6 | Washington (MO) | 14 | Saint Louis, MO | |
| 1921 | L | Tulane JV (LA) | 7 | Louisiana-Lafayette | 13 | ? | |
| 1921 | L | Tulare HS (CA) | 0 | Selma HS (CA) | 12 | ? | |
| 1921 | W | Tulsa (OK) | 92 | East Central (OK) | 0 | Tulsa, OK | |
| 1921 | L | Tulsa (OK) | 0 | Haskell Indian Nations (KS) | 21 | Kansas City, MO | |
| 1921 | W | Tulsa (OK) | 24 | Kingfisher (OK) | 7 | Tulsa, OK | |
| 1921 | W | Tulsa (OK) | 17 | Northwestern Oklahoma St. | 7 | Tulsa, OK | |
| 1921 | W | Tulsa (OK) | 21 | Phillips (OK) | 10 | Tulsa, OK | |
| 1921 | L | Tulsa (OK) | 0 | Texas Christian | 16 | Fort Worth, TX | |
| 1921 | W | Tulsa (OK) | 28 | Oklahoma Baptist University | 0 | Shawnee, OK | |
| 1921 | W | Tulsa (OK) | 75 | Chilocco Indian School (OK) | 13 | Tulsa, OK | |
| 1921 | L | Tulsa (OK) | 0 | Central Oklahoma | 21 | Tulsa, OK | |
| 1921 | W | Tulsa Central HS (OK) | 46 | Dewey HS (OK) | 0 | ? | |
| 1921 | W | Tulsa Central HS (OK) | 17 | Fort Smith HS (AR) | 0 | ? | |
| 1921 | W | Tulsa Central HS (OK) | 10 | Guthrie HS (OK) | 0 | ? | |
| 1921 | T | Tulsa Central HS (OK) | 7 | Nowata HS (OK) | 7 | ? | |
| 1921 | W | Tulsa Central HS (OK) | 14 | Oklahoma City HS (OK) | 7 | ? | |
| 1921 | W | Tulsa Central HS (OK) | 27 | Okmulgee HS (OK) | 0 | ? | |
| 1921 | W | Tulsa Central HS (OK) | 14 | Ramona HS (OK) | 6 | ? | |
| 1921 | L | Tulsa Central HS (OK) | 0 | Sapulpa HS (OK) | 33 | ? | |
| 1921 | L | Tulsa Central HS (OK) | 0 | Shawnee HS (OK) | 7 | ? | |
| 1921 | W | Tulsa Central HS (OK) | 14 | Wetumka HS (OK) | 0 | ? | |
| 1921 | W | Tulsa Central HS (OK) | 2 | Wichita HS (KS) | 0 | ? | |
| 1921 | W | Tulsa JV (OK) | 3 | Sapulpa HS (OK) | 0 | ? | Tulsa JV in question |
| 1921 | L | Tulsa Senior HS (OK) | 0 | Collinsville HS (OK) | 3 | ? | |
| 1921 | L | Tunica Agriculture (MS) | 0 | Clarksdale HS (MS) | 65 | ? | |
| 1921 | W | Tunkhannock HS (PA) | 26 | Athens HS (PA) | 0 | ? | |
| 1921 | W | Tunkhannock HS (PA) | 26 | Athens HS (PA) | 6 | ? | |
| 1921 | L | Tupelo Military Institute (MS) | 0 | Pine Bluff HS (AR) | 27 | ? | |
| 1921 | T | Tusculum (TN) | 0 | Carson-Newman (TN) | 0 | ? | Score unknown |
| 1921 | L | Tusculum (TN) | 0 | East Tennessee St. | 20 | ? | |
| 1921 | L | Tusculum (TN) | 0 | King College (TN) | 28 | Greeneville, TN | |
| 1921 | L | Tusculum (TN) | 0 | Milligan (TN) | 14 | ? | |
| 1921 | T | Tusculum (TN) | 0 | Tennessee B Team | 0 | ? | Score unknown |
| 1921 | T | Tusculum (TN) | 0 | Tennessee Wesleyan | 0 | ? | Score unknown |
| 1921 | T | Tusculum (TN) | 0 | Emory & Henry (VA) | 0 | Bristol, TN | Score unknown |
| 1921 | W | Tuskegee (AL) | 13 | Atlanta (GA) | 0 | ? | |
| 1921 | L | Tuskegee (AL) | 2 | Fisk (TN) | 7 | ? | |
| 1921 | T | Tuskegee (AL) | 0 | Florida A&M | 0 | ? | |
| 1921 | W | Tuskegee (AL) | 13 | Fort Benning (GA) | 0 | ? | |
| 1921 | W | Tuskegee (AL) | 6 | Fort Benning (GA) | 4 | ? | |
| 1921 | T | Tuskegee (AL) | 13 | Morris Brown (GA) | 13 | ? | |
| 1921 | W | Tuskegee (AL) | 21 | Paine (GA) | 0 | ? | |
| 1921 | L | Tuskegee (AL) | 7 | Talladega (AL) | 39 | Birmingham, AL | Rickwood Field |
| 1921 | L | Twin Falls HS (ID) | 3 | Boise HS (ID) | 5 | ? | |
| 1921 | W | Twin Falls HS (ID) | 56 | Buhl HS (ID) | 0 | ? | |
| 1921 | W | Twin Falls HS (ID) | 26 | Filer HS (ID) | 0 | ? | |
| 1921 | W | Twin Falls HS (ID) | 111 | Jerome HS (ID) | 0 | ? | |
| 1921 | W | Twin Falls HS (ID) | 21 | Nampa HS (ID) | 0 | ? | |
| 1921 | L | Twin Falls HS (ID) | 0 | Salt Lake City East Side HS (UT) | 14 | ? | |
| 1921 | W | Twin Falls HS (ID) | 133 | Wendell HS (ID) | 0 | ? | |
| 1921 | W | Twin Falls HS (ID) | 28 | Wendell HS (ID) | 7 | ? | |
| 1921 | L | Two Harbors HS (MN) | 14 | Aurora HS (MN) | 28 | ? | |
| 1921 | W | Tyrone HS (PA) | 6 | Curwensville HS (PA) | 0 | ? | |
| 1921 | L | Tyrone HS (PA) | 0 | Curwensville HS (PA) | 31 | ? | |
| 1921 | L | UCLA | 0 | Occidental (CA) | 35 | Los Angeles, CA | |
| 1921 | L | UCLA | 7 | Pomona-Pitzer (CA) | 55 | Los Angeles, CA | |
| 1921 | L | UCLA | 0 | Whittier (CA) | 62 | Los Angeles, CA | |
| 1921 | L | UCLA | 7 | Redlands (CA) | 35 | Los Angeles, CA | |
| 1921 | L | UCLA | 0 | California Tech | 27 | Pasadena, CA | |
| 1921 | L | UCLA Freshmen | 0 | Loyola Marymount (CA) | 13 | ? | |
| 1921 | L | Ukiah HS (CA) | 13 | Santa Rosa HS (CA) | 26 | ? | |
| 1921 | L | Ulysses HS (PA) | 0 | Mansfield (PA) | 120 | ? | |
| 1921 | L | Union (NY) | 0 | Amherst (MA) | 6 | Schenectady, NY | |
| 1921 | L | Union (NY) | 0 | Hamilton (NY) | 7 | Clinton, NY | |
| 1921 | L | Union (NY) | 7 | Hobart (NY) | 21 | Schenectady, NY | |
| 1921 | L | Union (NY) | 7 | Rochester (NY) | 28 | Schenectady, NY | |
| 1921 | W | Union (NY) | 14 | Clarkson (NY) | 0 | Schenectady, NY | |
| 1921 | L | Union (NY) | 0 | Williams (MA) | 44 | Williamstown, MA | |
| 1921 | W | Union (NY) | 9 | Saint Lawrence (NY) | 7 | Schenectady, NY | |
| 1921 | W | Union (NY) | 7 | Wesleyan (CT) | 0 | Schenectady, NY | |
| 1921 | L | Union (TN) | 7 | Cumberland (TN) | 19 | ? | |
| 1921 | W | Union (TN) | 27 | Memphis (TN) | 7 | Jackson, TN | |
| 1921 | T | Union (TN) | 0 | Middle Tennessee St. | 0 | Jackson, TN | |
| 1921 | L | Union (TN) | 0 | Mississippi College | 34 | Clinton, MS | |
| 1921 | W | Union (TN) | 27 | Rhodes (TN) | 0 | Jackson, TN | |
| 1921 | W | Union (TN) | 26 | Western Kentucky | 0 | ? | |
| 1921 | W | Union (TN) | 14 | Bethel (KY) | 0 | ? | |
| 1921 | L | Union (TN) | 0 | Tennessee Medical College | 14 | Memphis, TN | |
| 1921 | W | Union (TN) | 28 | Lyon College (AR) | 0 | Jackson, TN | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Bloomfield HS (NJ) | 61 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Cliffside Park HS (NJ) | 26 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Clifton HS (NJ) | 32 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 7 | Hoboken Stevens Prep HS (NJ) | 18 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Jersey City Lincoln HS (NJ) | 6 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Lincoln HS | 7 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Ramsey HS (NJ) | 31 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Saint Peter's Prep (NJ) | 36 | ? | |
| 1921 | L | Union City Emerson HS (NJ) | 0 | Trenton HS (NJ) | 26 | ? | |
| 1921 | W | Union City Emerson HS (NJ) | 13 | Union Hill HS (NJ) | 6 | ? | |
| 1921 | L | Union Freshmen (NY) | 7 | Saratoga Springs HS (NY) | 19 | ? | |
| 1921 | L | Union Hill HS (NJ) | 0 | Cliffside Park HS (NJ) | 34 | ? | |
| 1921 | W | Union Hill HS (NJ) | 7 | Irvington HS (NJ) | 6 | ? | |
| 1921 | L | Union Hill HS (NJ) | 0 | Jersey City Lincoln HS (NJ) | 36 | ? | |
| 1921 | L | Union Hill HS (NJ) | 6 | Leonia HS (NJ) | 7 | ? | |
| 1921 | L | Union Hill HS (NJ) | 0 | Nutley HS (NJ) | 67 | ? | |
| 1921 | L | Union Hill HS (NJ) | 0 | Ridgefield Park HS (NJ) | 20 | ? | |
| 1921 | T | Union Hill HS (NJ) | 7 | Rutherford East HS (NJ) | 7 | ? | |
| 1921 | L | Union Hill HS (NJ) | 6 | Union City Emerson HS (NJ) | 13 | ? | |
| 1921 | T | Union HS (PA) | 0 | Wilkinsburg HS (PA) | 0 | ? | |
| 1921 | L | Union Theological Seminary (VA) | 0 | Hampden-Sydney (VA) | 21 | Hampden-Sydney, VA | |
| 1921 | L | Union Theological Seminary (VA) | 0 | William & Mary (VA) | 76 | Williamsburg, VA | |
| 1921 | W | Uniontown HS (PA) | 16 | Morgantown HS (WV) | 0 | ? | |
| 1921 | L | University City HS (MO) | 0 | Chaminade College HS (MO) | 7 | ? | |
| 1921 | L | University City HS (MO) | 0 | Webster Groves HS (MO) | 7 | ? | |
| 1921 | L | University of Arkansas HS | 7 | Rogers HS (AR) | 10 | ? | |
| 1921 | L | University of Dayton Prep | 0 | Miami Military Institute (OH) | 7 | ? | |
| 1921 | L | University Prep School (OK) | 0 | Central Oklahoma | 21 | ? | |
| 1921 | L | University Prep School (OK) | 0 | Northwestern Oklahoma St. | 23 | ? | |
| 1921 | L | University Prep School (OK) | 0 | Oklahoma City (OK) | 20 | ? | |
| 1921 | L | University Prep School (OK) | 7 | Southwestern Oklahoma St. | 21 | ? | |
| 1921 | W | University School | 21 | Athens HS (GA) | 7 | ? | |
| 1921 | W | University School | 14 | Atlanta Boy's HS (GA) | 7 | ? | |
| 1921 | L | University School | 0 | Laramie HS (WY) | 52 | ? | |
| 1921 | L | Upper Darby HS (PA) | 0 | Darby HS (PA) | 14 | ? | |
| 1921 | L | Upper Darby HS (PA) | 0 | Glassboro HS (NJ) | 32 | ? | |
| 1921 | L | Upper Darby HS (PA) | 0 | Lower Merion HS (PA) | 52 | ? | |
| 1921 | L | Upper Darby HS (PA) | 6 | Palmyra HS (NJ) | 33 | ? | |
| 1921 | W | Upper Darby HS (PA) | 7 | Quakertown HS (PA) | 6 | ? | |
| 1921 | W | Upper Iowa | 49 | Ellsworth CC (IA) | 0 | Fayette, IA | |
| 1921 | L | Upper Iowa | 7 | Loras (IA) | 24 | Fayette, IA | |
| 1921 | L | Upper Iowa | 0 | Morningside (IA) | 27 | Sioux City, IA | |
| 1921 | T | Upper Iowa | 0 | Northern Iowa | 0 | Cedar Falls, IA | |
| 1921 | W | Upper Iowa | 13 | Simpson (IA) | 7 | Indianola, IA | |
| 1921 | L | Upper Iowa | 6 | Cornell College (IA) | 20 | Mount Vernon, IA | |
| 1921 | L | Upper Iowa | 7 | Luther (IA) | 33 | Decorah, IA | |
| 1921 | L | Upsala | 21 | Stamford HS (CT) | 35 | ? | |
| 1921 | L | Upsala (NJ) | 0 | Battin HS (NJ) | 28 | ? | |
| 1921 | W | Upsala (NJ) | 32 | Carlton Academy (NJ) | 0 | ? | |
| 1921 | L | Upsala (NJ) | 7 | Concordia Prep School (NY) | 21 | ? | |
| 1921 | W | Upsala (NJ) | 7 | Saint Benedict Prep School (NJ) | 0 | ? | |
| 1921 | L | Upsala (NJ) | 6 | Saint Peter's Prep (NJ) | 26 | ? | |
| 1921 | L | Upsala (NJ) | 14 | Brooklyn Evening HS (NY) | 31 | East Orange, NJ | |
| 1921 | W | Urbana HS (IL) | 34 | Danville HS (IL) | 2 | ? | |
| 1921 | L | Urbana HS (OH) | 0 | London HS (OH) | 66 | ? | |
| 1921 | L | Ursinus (PA) | 0 | Dickinson (PA) | 20 | Collegeville, PA | |
| 1921 | L | Ursinus (PA) | 0 | Gettysburg (PA) | 34 | York, PA | |
| 1921 | W | Ursinus (PA) | 13 | Haverford (PA) | 7 | Collegeville, PA | |
| 1921 | L | Ursinus (PA) | 0 | Muhlenberg (PA) | 68 | Allentown, PA | |
| 1921 | L | Ursinus (PA) | 0 | Rutgers (NJ) | 33 | Collegeville, PA | |
| 1921 | L | Ursinus (PA) | 0 | Villanova (PA) | 6 | Collegeville, PA | |
| 1921 | L | Ursinus (PA) | 0 | Widener (PA) | 12 | Chester, PA | |
| 1921 | L | Ursinus (PA) | 6 | Georgetown (DC) | 48 | Washington, DC | |
| 1921 | L | Ursinus (PA) | 0 | Franklin & Marshall (PA) | 41 | Lancaster, PA | |
| 1921 | L | US Marines | 0 | Stanford (CA) | 41 | Stanford, CA | |
| 1921 | L | USMC Portsmouth (NH) | 0 | New Hampshire | 55 | Dover, NH | |
| 1921 | L | USS Arizona | 0 | Southern California | 62 | Los Angeles, CA | |
| 1921 | W | USS Birmingham | 14 | San Diego St. (CA) | 0 | San Diego, CA | College Field |
| 1921 | L | USS Birmingham | 6 | San Diego St. (CA) | 14 | San Diego, CA | College Field |
| 1921 | L | USS Charleston | 0 | San Diego HS (CA) | 35 | ? | |
| 1921 | L | USS Cumberland | 0 | Washington Dunbar HS (DC) | 6 | ? | |
| 1921 | L | USS Melville | 0 | San Diego HS (CA) | 25 | ? | |
| 1921 | L | USS New York | 6 | California Tech | 14 | ? | |
| 1921 | L | USS New York | 0 | Southern California | 35 | Los Angeles, CA | |
| 1921 | W | Utah | 14 | Colorado College | 3 | Colorado Springs, CO | |
| 1921 | W | Utah | 17 | Idaho | 7 | Salt Lake City, UT | |
| 1921 | L | Utah | 3 | Utah St. | 14 | Salt Lake City, UT | |
| 1921 | W | Utah | 14 | Wyoming | 3 | Salt Lake City, UT | |
| 1921 | L | Utah | 7 | Nevada | 28 | Reno, NV | |
| 1921 | T | Utah | 0 | Colorado | 0 | Salt Lake City, UT | |
| 1921 | W | Utah Freshmen | 16 | Brigham Young (UT) | 0 | Provo, UT | |
| 1921 | W | Utah Freshmen | 16 | Brigham Young (UT) | 14 | Salt Lake City, UT | Cummings Field |
| 1921 | W | Utah Freshmen | 3 | Idaho St. | 0 | Pocatello, ID | |
| 1921 | W | Utah St. | 30 | Montana St. | 7 | Logan, UT | |
| 1921 | W | Utah St. | 3 | Montana Tech | 0 | Butte, MT | |
| 1921 | L | Utah St. | 0 | Nevada | 41 | Logan, UT | |
| 1921 | W | Utah St. | 14 | Utah | 3 | Salt Lake City, UT | |
| 1921 | W | Utah St. | 23 | Colorado School of Mines | 7 | Pueblo, CO | |
| 1921 | W | Utah St. | 47 | Ogden AC (UT) | 21 | Logan, UT | |
| 1921 | W | Utah St. | 14 | Wyoming | 3 | Logan, UT | |
| 1921 | W | Utah St. | 20 | College of Idaho | 0 | Logan, UT | |
| 1921 | L | Utah St. Freshmen | 0 | Brigham Young (UT) | 21 | ? | |
| 1921 | W | Utah St. Freshmen | 37 | Brigham Young (UT) | 0 | ? | |
| 1921 | T | Utah St. Freshmen | 7 | Brigham Young College (UT) | 7 | ? | |
| 1921 | L | Utah St. Freshmen | 0 | Idaho St. | 34 | Pocatello, ID | |
| 1921 | L | Utica Free Academy (NY) | 0 | Binghamton Central HS (NY) | 14 | ? | |
| 1921 | L | Utica Free Academy (NY) | 9 | Herkimer HS (NY) | 14 | ? | |
| 1921 | L | Utica Free Academy (NY) | 0 | Sherrill HS (NY) | 12 | ? | |
| 1921 | T | Utica Free Academy (NY) | 0 | Syracuse Central HS (NY) | 0 | ? | |
| 1921 | L | Utica Free Academy (NY) | 0 | Syracuse North HS (NY) | 13 | ? | |
| 1921 | L | V.S.B.D. | 13 | Fishburne Military School (VA) | 26 | ? | |
| 1921 | L | Vallejo Moose HS | 0 | Mount Diablo HS (CA) | 13 | ? | |
| 1921 | L | Vallejo Moose HS | 0 | Tamalpais HS (CA) | 28 | ? | |
| 1921 | L | Valley City St. (ND) | 7 | Jamestown (ND) | 28 | ? | |
| 1921 | W | Valley City St. (ND) | 7 | Moorhead St. (MN) | 6 | ? | |
| 1921 | L | Valley Junction HS | 0 | Cedar Rapids HS (IA) | 32 | ? | |
| 1921 | L | Valparaiso (IN) | 0 | DePauw (IN) | 41 | Greencastle, IN | |
| 1921 | T | Valparaiso (IN) | 0 | Saint Viator (IL) | 0 | Bourbonnais, IL | |
| 1921 | W | Valparaiso (IN) | 14 | Milwaukee School of Engineering (WI) | 0 | Valparaiso, IN | |
| 1921 | W | Valparaiso (IN) | 59 | Saint Joseph's (IN) | 0 | Collegeville, IN | |
| 1921 | L | Valparaiso (IN) | 0 | Kalamazoo (MI) | 12 | Valparaiso, IN | |
| 1921 | W | Van Buren HS (AR) | 110 | Charleston HS (AR) | 0 | ? | |
| 1921 | W | Van Buren HS (AR) | 27 | Fayetteville HS (AR) | 0 | ? | |
| 1921 | W | Van Buren HS (AR) | 34 | Keota HS (OK) | 0 | ? | |
| 1921 | W | Van Buren HS (AR) | 75 | Ozark HS (AR) | 0 | ? | |
| 1921 | L | Van Buren HS (AR) | 0 | Paris HS (AR) | 82 | ? | |
| 1921 | W | Van Buren HS (AR) | 7 | Rogers HS (AR) | 0 | ? | |
| 1921 | L | Van Buren HS (AR) | 0 | Russellville HS (AR) | 21 | ? | |
| 1921 | L | Van Buren HS (AR) | 0 | Stigler HS (OK) | 7 | ? | |
| 1921 | L | Van Buren HS (OH) | 0 | Mount Cory HS (OH) | 72 | ? | |
| 1921 | L | Van Buren HS (OH) | 6 | Mount Cory HS (OH) | 20 | ? | |
| 1921 | L | Van Nuys HS (CA) | 7 | Santa Ana HS (CA) | 55 | ? | |
| 1921 | L | Vancouver HS (WA) | 0 | Chehalis HS (WA) | 16 | ? | |
| 1921 | W | Vancouver HS (WA) | 28 | James John HS (OR) | 7 | ? | |
| 1921 | T | Vanderbilt (TN) | 7 | Georgia | 7 | Nashville, TN | |
| 1921 | W | Vanderbilt (TN) | 21 | Kentucky | 14 | Lexington, KY | |
| 1921 | W | Vanderbilt (TN) | 9 | Sewanee (TN) | 0 | Nashville, TN | |
| 1921 | W | Vanderbilt (TN) | 14 | Tennessee | 0 | Nashville, TN | |
| 1921 | W | Vanderbilt (TN) | 20 | Texas | 0 | Dallas, TX | |
| 1921 | W | Vanderbilt (TN) | 34 | Middle Tennessee St. | 0 | Nashville, TN | |
| 1921 | W | Vanderbilt (TN) | 14 | Alabama | 0 | Birmingham, AL | |
| 1921 | W | Vanderbilt (TN) | 42 | Mercer (GA) | 0 | Nashville, TN | |
| 1921 | L | Vanderbilt JV (TN) | 13 | Middle Tennessee St. | 14 | Murfreesboro, TN | |
| 1921 | W | Vanderbilt JV (TN) | 12 | Western Kentucky | 0 | ? | |
| 1921 | L | Vanlue HS (OH) | 0 | Mount Blanchard HS (OH) | 13 | ? | |
| 1921 | L | Vanlue HS (OH) | 0 | Mount Blanchard HS (OH) | 10 | ? | |
| 1921 | L | Venice HS (CA) | 0 | Los Angeles Jefferson HS (CA) | 21 | ? | |
| 1921 | W | Venice HS (CA) | 27 | Santa Barbara HS (CA) | 21 | ? | |
| 1921 | T | Venice HS (CA) | 0 | South Pasadena HS (CA) | 0 | ? | |
| 1921 | L | Vermont | 0 | Detroit (MI) | 21 | Detroit, MI | |
| 1921 | W | Vermont | 14 | Massachusetts | 7 | Amherst, MA | |
| 1921 | L | Vermont | 7 | New Hampshire | 21 | Burlington, VT | |
| 1921 | W | Vermont | 6 | Tufts (MA) | 0 | Medford, MA | |
| 1921 | L | Vermont | 0 | Yale (CT) | 14 | New Haven, CT | |
| 1921 | W | Vermont | 14 | Norwich (VT) | 2 | Northfield, VT | |
| 1921 | W | Vermont | 14 | Middlebury (VT) | 7 | Burlington, VT | |
| 1921 | L | Verona HS (PA) | 0 | North Braddock HS (PA) | 33 | ? | |
| 1921 | L | Villa Grove HS (IL) | 0 | Danville HS (IL) | 39 | ? | |
| 1921 | T | Villanova (PA) | 0 | Canisius (NY) | 0 | Buffalo, NY | |
| 1921 | W | Villanova (PA) | 7 | Catholic (DC) | 0 | Washington, DC | |
| 1921 | T | Villanova (PA) | 20 | Fordham (NY) | 20 | New York, NY | |
| 1921 | W | Villanova (PA) | 41 | Lebanon Valley (PA) | 7 | Norristown, PA | |
| 1921 | W | Villanova (PA) | 7 | Mount Saint Mary's (MD) | 0 | Villanova, PA | |
| 1921 | W | Villanova (PA) | 6 | Ursinus (PA) | 0 | Collegeville, PA | |
| 1921 | W | Villanova (PA) | 13 | Gettysburg (PA) | 10 | York, PA | |
| 1921 | W | Villanova (PA) | 19 | Widener (PA) | 7 | Chester, PA | |
| 1921 | L | Villanova (PA) | 0 | Army (NY) | 49 | West Point, NY | |
| 1921 | T | Villanova Prep School (PA) | 7 | Delaware Valley (PA) | 7 | ? | |
| 1921 | W | Villanova Prep School (PA) | 13 | Philadelphia Catholic HS (PA) | 7 | ? | |
| 1921 | L | Villanova Prep School (PA) | 6 | Philadelphia West Catholic HS (PA) | 7 | ? | |
| 1921 | W | Villanova Prep School (PA) | 7 | Philadelphia West Catholic HS (PA) | 0 | ? | |
| 1921 | L | Villanova Prep School (PA) | 10 | Saint Joseph's Prep School (PA) | 21 | ? | |
| 1921 | W | Villanova Prep School (PA) | 6 | Saint Joseph's Prep School (PA) | 0 | ? | |
| 1921 | W | Villanova Prep School (PA) | 41 | Saint Matthew's Prep | 0 | ? | |
| 1921 | T | Villanova Prep School (PA) | 0 | Williamson Trade School (PA) | 0 | ? | |
| 1921 | W | Villanova Prep School (PA) | 10 | Wilmington HS (DE) | 7 | ? | |
| 1921 | L | Vineland HS (NJ) | 11 | Hammonton HS (NJ) | 21 | ? | |
| 1921 | T | Vineland HS (NJ) | 0 | Millville HS (NJ) | 0 | ? | |
| 1921 | T | Vineland HS (NJ) | 0 | Moorestown HS (NJ) | 0 | ? | |
| 1921 | L | Vineland HS (NJ) | 0 | Penns Grove HS (NJ) | 6 | ? | |
| 1921 | L | Vineland HS (NJ) | 7 | Woodbury HS (NJ) | 27 | ? | |
| 1921 | W | Virginia | 28 | Davidson (NC) | 0 | Charlottesville, VA | |
| 1921 | W | Virginia | 14 | Johns Hopkins (MD) | 7 | Charlottesville, VA | |
| 1921 | L | Virginia | 3 | North Carolina | 7 | Chapel Hill, NC | |
| 1921 | L | Virginia | 0 | Princeton (NJ) | 34 | Princeton, NJ | |
| 1921 | W | Virginia | 14 | Virginia Military Institute | 7 | Lexington, VA | |
| 1921 | W | Virginia | 28 | George Washington (DC) | 0 | Charlottesville, VA | |
| 1921 | L | Virginia | 0 | Georgia | 21 | Athens, GA | |
| 1921 | W | Virginia | 14 | Richmond (VA) | 0 | Charlottesville, VA | |
| 1921 | L | Virginia | 0 | West Virginia | 7 | Charlottesville, VA | |
| 1921 | W | Virginia Episcopal School (VA) | 13 | Charlottesville HS (VA) | 0 | ? | |
| 1921 | L | Virginia Episcopal School (VA) | 0 | Lynchburg HS (VA) | 6 | ? | |
| 1921 | W | Virginia Episcopal School (VA) | 48 | McGuire's University School | 0 | ? | |
| 1921 | W | Virginia Episcopal School (VA) | 13 | Randolph-Macon Academy (VA) | 7 | ? | |
| 1921 | W | Virginia Episcopal School (VA) | 13 | Roanoke HS (VA) | 0 | ? | |
| 1921 | W | Virginia Episcopal School (VA) | 14 | Shenandoah Military Academy (VA) | 0 | ? | |
| 1921 | L | Virginia Episcopal School (VA) | 6 | Woodberry Forest School (VA) | 7 | ? | |
| 1921 | L | Virginia Freshmen | 0 | Newport News Apprentice School (VA) | 8 | ? | |
| 1921 | W | Virginia Freshmen | 21 | Washington Technical HS (DC) | 13 | ? | |
| 1921 | W | Virginia Freshmen | 13 | Woodberry Forest School (VA) | 7 | ? | |
| 1921 | L | Virginia HS (IL) | 3 | Lincoln HS (IL) | 27 | ? | |
| 1921 | W | Virginia HS (MN) | 14 | Duluth Denfeld HS (MN) | 7 | ? | |
| 1921 | T | Virginia Military Institute | 7 | North Carolina St. | 7 | Raleigh, NC | |
| 1921 | L | Virginia Military Institute | 7 | Pennsylvania | 21 | Philadelphia, PA | |
| 1921 | W | Virginia Military Institute | 13 | Roanoke (VA) | 0 | Lexington, VA | |
| 1921 | L | Virginia Military Institute | 7 | Virginia | 14 | Lexington, VA | |
| 1921 | L | Virginia Military Institute | 7 | Virginia Tech | 26 | Roanoke, VA | |
| 1921 | W | Virginia Military Institute | 32 | Hampden-Sydney (VA) | 0 | Lexington, VA | |
| 1921 | L | Virginia Military Institute | 7 | North Carolina | 20 | Richmond, VA | |
| 1921 | W | Virginia Military Institute | 20 | Wake Forest (NC) | 0 | Lexington, VA | |
| 1921 | L | Virginia Military Institute | 7 | Kentucky | 14 | Louisville, KY | |
| 1921 | L | Virginia Military Institute JV | 0 | Staunton Military Academy (VA) | 21 | ? | |
| 1921 | T | Virginia St. | 0 | Adelphia Social Club | 0 | ? | |
| 1921 | W | Virginia St. | 14 | Hampton (VA) | 3 | Hampton, VA | |
| 1921 | L | Virginia St. | 0 | Howard (DC) | 19 | Washington, DC | |
| 1921 | T | Virginia St. | 0 | Johnson C. Smith (NC) | 0 | ? | |
| 1921 | W | Virginia St. | 85 | Morgan St. (MD) | 0 | Richmond, VA | |
| 1921 | W | Virginia St. | 14 | North Carolina A&T | 0 | ? | |
| 1921 | W | Virginia St. | 52 | Saint Paul's (VA) | 7 | Richmond, VA | |
| 1921 | W | Virginia St. | 13 | Virginia-Lynchburg | 0 | Lynchburg, VA | |
| 1921 | W | Virginia St. | 13 | Virginia-Lynchburg | 0 | ? | |
| 1921 | W | Virginia St. | 7 | Saint Augustine's (NC) | 0 | Petersburg, VA | |
| 1921 | W | Virginia St. | 1 | Lincoln (PA) | 0 | Richmond, VA | Lincoln Forfeits |
| 1921 | W | Virginia Tech | 14 | Hampden-Sydney (VA) | 6 | Blacksburg, VA | |
| 1921 | L | Virginia Tech | 7 | Maryland | 10 | Washington, DC | |
| 1921 | W | Virginia Tech | 34 | Richmond (VA) | 0 | Richmond, VA | |
| 1921 | W | Virginia Tech | 35 | Roanoke (VA) | 0 | Blacksburg, VA | |
| 1921 | W | Virginia Tech | 26 | Virginia Military Institute | 7 | Roanoke, VA | |
| 1921 | L | Virginia Tech | 0 | Washington & Lee (VA) | 3 | Lynchburg, VA | |
| 1921 | W | Virginia Tech | 14 | William & Mary (VA) | 0 | Blacksburg, VA | |
| 1921 | W | Virginia Tech | 54 | Charleston (WV) | 7 | Blacksburg, VA | |
| 1921 | L | Virginia Tech | 0 | Centre (KY) | 14 | Danville, KY | |
| 1921 | W | Virginia Tech | 7 | North Carolina St. | 3 | Norfolk, VA | |
| 1921 | W | Virginia Tech JV | 14 | Newport News Apprentice School (VA) | 6 | ? | |
| 1921 | T | Virginia Union | 0 | Adelphia Social Club | 0 | ? | |
| 1921 | W | Virginia Union | 14 | Hampton (VA) | 3 | Hampton, VA | |
| 1921 | W | Virginia Union | 85 | Morgan St. (MD) | 0 | Richmond, VA | |
| 1921 | W | Virginia Union | 14 | North Carolina A&T | 0 | ? | |
| 1921 | W | Virginia Union | 52 | Saint Paul's (VA) | 7 | Richmond, VA | |
| 1921 | W | Virginia Union | 13 | Virginia-Lynchburg | 0 | Lynchburg, VA | |
| 1921 | W | Virginia Union | 1 | Lincoln (PA) | 0 | Richmond, VA | Lincoln Forfeits |
| 1921 | L | Virginia-Lynchburg | 0 | Howard (DC) | 26 | ? | |
| 1921 | W | Virginia-Lynchburg | 72 | Kittrell College (NC) | 0 | ? | |
| 1921 | W | Virginia-Lynchburg | 13 | Saint Augustine's (NC) | 0 | ? | |
| 1921 | L | Virginia-Lynchburg | 6 | Saint Paul's (VA) | 7 | ? | |
| 1921 | W | Virginia-Lynchburg | 33 | Storer College (WV) | 7 | ? | |
| 1921 | L | Virginia-Lynchburg | 0 | Virginia St. | 13 | ? | |
| 1921 | L | Virginia-Lynchburg | 0 | Virginia Union | 13 | Lynchburg, VA | |
| 1921 | W | Virginia-Lynchburg | 3 | West Virginia St. | 0 | ? | |
| 1921 | L | Visalia HS (CA) | 0 | Dinuba HS (CA) | 25 | ? | |
| 1921 | L | Wabash (IN) | 0 | Army (NY) | 21 | West Point, NY | |
| 1921 | W | Wabash (IN) | 7 | Augustana (IL) | 0 | Crawfordsville, IN | |
| 1921 | W | Wabash (IN) | 14 | Butler (IN) | 0 | Indianapolis, IN | |
| 1921 | W | Wabash (IN) | 22 | DePauw (IN) | 0 | Indianapolis, IN | |
| 1921 | L | Wabash (IN) | 0 | Marquette (WI) | 7 | Milwaukee, WI | |
| 1921 | W | Wabash (IN) | 9 | Purdue (IN) | 0 | West Lafayette, IN | |
| 1921 | W | Wabash (IN) | 14 | Millikin (IL) | 3 | Crawfordsville, IN | |
| 1921 | W | Wabash (IN) | 41 | Georgetown (KY) | 0 | Crawfordsville, IN | |
| 1921 | W | Wabash (IN) | 39 | Rose-Hulman Tech (IN) | 0 | Crawfordsville, IN | |
| 1921 | L | Wabash HS (IN) | 6 | Dayton Steele HS (OH) | 109 | ? | |
| 1921 | L | Wabash HS (IN) | 7 | Indianapolis Shortridge HS (IN) | 32 | ? | |
| 1921 | L | Wabasha HS (MN) | 3 | Red Wing HS (MN) | 51 | ? | |
| 1921 | W | Waco HS (TX) | 63 | Beaumont HS (TX) | 0 | ? | |
| 1921 | L | Wadena HS (MN) | 3 | Alexandria HS (MN) | 80 | ? | |
| 1921 | W | Wadena HS (MN) | 7 | Detroit HS (MN) | 0 | ? | |
| 1921 | W | Wadena HS (MN) | 51 | Fergus Falls HS (MN) | 0 | ? | |
| 1921 | W | Wadena HS (MN) | 38 | Long Prairie HS (MN) | 0 | ? | |
| 1921 | W | Wadena HS (MN) | 27 | Park Rapids HS (MN) | 0 | ? | |
| 1921 | L | Wahpeton HS (ND) | 0 | Moorhead HS (MN) | 26 | ? | |
| 1921 | W | Wake Forest (NC) | 10 | Davidson (NC) | 7 | Charlotte, NC | |
| 1921 | L | Wake Forest (NC) | 0 | Georgia Tech | 42 | Atlanta, GA | |
| 1921 | W | Wake Forest (NC) | 28 | Guilford (NC) | 0 | Wake Forest, NC | |
| 1921 | L | Wake Forest (NC) | 14 | Hampden-Sydney (VA) | 39 | Norfolk, VA | |
| 1921 | L | Wake Forest (NC) | 0 | North Carolina St. | 14 | Raleigh, NC | |
| 1921 | L | Wake Forest (NC) | 14 | William & Mary (VA) | 21 | Williamsburg, VA | |
| 1921 | L | Wake Forest (NC) | 0 | North Carolina | 21 | Chapel Hill, NC | |
| 1921 | L | Wake Forest (NC) | 0 | Richmond (VA) | 41 | Richmond, VA | |
| 1921 | L | Wake Forest (NC) | 0 | Virginia Military Institute | 20 | Lexington, VA | |
| 1921 | L | Wake Forest (NC) | 0 | Duke (NC) | 17 | Raleigh, NC | |
| 1921 | L | Wake Forest JV (NC) | 13 | Atlantic Christian (NC) | 14 | ? | |
| 1921 | L | Wakefield HS (MA) | 0 | Amesbury HS (MA) | 14 | ? | |
| 1921 | W | Wakefield HS (MA) | 7 | Arlington HS (MA) | 0 | ? | |
| 1921 | W | Wakefield HS (MA) | 14 | Lexington HS (MA) | 7 | ? | |
| 1921 | L | Wakefield HS (MA) | 0 | Lowell HS (MA) | 25 | ? | |
| 1921 | W | Wakefield HS (MA) | 27 | Melrose HS (MA) | 0 | ? | |
| 1921 | L | Wakefield HS (MA) | 7 | Saint John's Prep (MA) | 19 | ? | |
| 1921 | W | Wakefield HS (MA) | 41 | Stoneham HS (MA) | 0 | ? | |
| 1921 | T | Wakefield HS (MA) | 7 | Watertown HS (MA) | 7 | ? | |
| 1921 | L | Wakefield HS (MA) | 0 | Winchester HS (MA) | 7 | ? | |
| 1921 | L | Wakefield HS (MA) | 7 | Woburn HS (MA) | 14 | ? | |
| 1921 | L | Walla Walla HS (WA) | 0 | Everett HS (WA) | 42 | ? | |
| 1921 | W | Walla Walla HS (WA) | 6 | Pendleton HS (OR) | 0 | ? | |
| 1921 | L | Wallace University School | 6 | Nashville Hume-Fogg HS (TN) | 77 | ? | |
| 1921 | W | Waltham HS (MA) | 13 | Boston College HS (MA) | 0 | ? | |
| 1921 | T | Waltham HS (MA) | 0 | Brockton HS (MA) | 0 | ? | |
| 1921 | W | Waltham HS (MA) | 17 | Dean Academy JV (MA) | 0 | ? | |
| 1921 | W | Waltham HS (MA) | 14 | Fitchburg HS (MA) | 13 | ? | |
| 1921 | W | Waltham HS (MA) | 13 | Framingham HS (MA) | 0 | ? | |
| 1921 | T | Waltham HS (MA) | 0 | Haverhill HS (MA) | 0 | ? | |
| 1921 | W | Waltham HS (MA) | 12 | Natick HS (MA) | 0 | ? | |
| 1921 | L | Waltham HS (MA) | 0 | Newton North HS (MA) | 27 | ? | |
| 1921 | T | Waltham HS (MA) | 0 | Portland HS (ME) | 0 | ? | |
| 1921 | W | Waltham HS (MA) | 34 | Providence Tech HS (RI) | 0 | ? | |
| 1921 | W | Waltham HS (MA) | 14 | Quincy HS (MA) | 0 | ? | |
| 1921 | L | Walton HS (NY) | 0 | Binghamton Central HS (NY) | 20 | ? | |
| 1921 | L | Walton HS (NY) | 0 | Endicott Union HS (NY) | 49 | ? | |
| 1921 | L | Wapakoneta HS (OH) | 0 | Saint Marys HS (OH) | 17 | ? | |
| 1921 | L | Wapakoneta HS (OH) | 0 | Saint Marys HS (OH) | 24 | ? | |
| 1921 | L | Ward Hill HS (MA) | 0 | Phillips Exeter Academy (NH) | 8 | ? | |
| 1921 | L | Ward Hill HS (MA) | 0 | Punchard HS (MA) | 13 | ? | |
| 1921 | L | Warner HS (OK) | 9 | Sapulpa HS (OK) | 21 | ? | |
| 1921 | L | Warren Easton Boys HS (LA) | 3 | Little Rock HS (AR) | 21 | ? | |
| 1921 | L | Warren HS (IL) | 0 | Freeport HS (IL) | 62 | ? | |
| 1921 | L | Warren HS (MN) | 0 | Crookston HS (MN) | 41 | ? | |
| 1921 | L | Warren HS (MN) | 0 | Stephen HS (MN) | 14 | ? | |
| 1921 | L | Warren HS (MN) | 0 | Stephen HS (MN) | 21 | ? | |
| 1921 | W | Warren HS (OH) | 44 | Akron Saint Vincent's HS (OH) | 0 | ? | |
| 1921 | W | Warren HS (OH) | 7 | Alliance HS (OH) | 0 | ? | |
| 1921 | W | Warren HS (OH) | 14 | Cuyahoga Falls HS (OH) | 6 | ? | |
| 1921 | L | Warren HS (OH) | 13 | East Cleveland Shaw HS (OH) | 20 | ? | |
| 1921 | W | Warren HS (OH) | 34 | Farrell HS (PA) | 0 | ? | |
| 1921 | W | Warren HS (OH) | 32 | Lisbon HS (OH) | 0 | ? | |
| 1921 | W | Warren HS (OH) | 13 | Massillon HS (OH) | 0 | ? | |
| 1921 | T | Warren HS (OH) | 0 | Niles HS (OH) | 0 | ? | |
| 1921 | W | Warren HS (OH) | 7 | Salem HS (OH) | 6 | ? | |
| 1921 | L | Warren HS (OH) | 0 | Sharon HS (PA) | 14 | ? | |
| 1921 | L | Warren HS (OH) | 7 | Youngstown South HS (OH) | 14 | ? | |
| 1921 | L | Warren HS (PA) | 0 | Kane HS (PA) | 21 | ? | |
| 1921 | W | Warren HS (PA) | 33 | Kane HS (PA) | 7 | ? | |
| 1921 | L | Warsaw HS (NC) | 7 | Rocky Mount HS (NC) | 14 | ? | |
| 1921 | L | Warwick HS | 6 | Westerly HS (RI) | 21 | ? | |
| 1921 | W | Warwood HS (WV) | 6 | Follansbee HS (WV) | 0 | ? | |
| 1921 | T | Warwood HS (WV) | 0 | Triadelphia HS (WV) | 0 | ? | |
| 1921 | L | Waseca HS (MN) | 0 | Mankato HS (MN) | 7 | ? | |
| 1921 | L | Waseca HS (MN) | 0 | Saint Peter HS (MN) | 46 | ? | |
| 1921 | W | Washburn (KS) | 17 | Baker (KS) | 16 | Topeka, KS | |
| 1921 | L | Washburn (KS) | 0 | Oklahoma St. | 13 | Stillwater, OK | |
| 1921 | T | Washburn (KS) | 0 | Ottawa (KS) | 0 | Ottawa, KS | |
| 1921 | L | Washburn (KS) | 3 | Saint Mary's (KS) | 14 | Topeka, KS | |
| 1921 | W | Washburn (KS) | 7 | Wichita St. (KS) | 6 | Topeka, KS | |
| 1921 | L | Washburn (KS) | 7 | Kansas | 28 | Topeka, KS | |
| 1921 | L | Washburn (KS) | 10 | Emporia St. (KS) | 13 | Topeka, KS | |
| 1921 | L | Washburn (KS) | 7 | Pittsburg St. (KS) | 21 | Topeka, KS | |
| 1921 | L | Washburn (KS) | 3 | College of Emporia (KS) | 6 | Emporia, KS | |
| 1921 | W | Washington | 28 | Montana | 7 | Seattle, WA | |
| 1921 | L | Washington | 0 | Oregon St. | 24 | Corvallis, OR | |
| 1921 | L | Washington | 0 | Washington St. | 14 | Seattle, WA | |
| 1921 | W | Washington | 24 | 9th Army Corps (WA) | 7 | Seattle, WA | |
| 1921 | L | Washington | 7 | Penn St. | 21 | Seattle, WA | |
| 1921 | T | Washington | 0 | Stanford (CA) | 0 | Seattle, WA | |
| 1921 | W | Washington | 7 | Whitman (WA) | 0 | Seattle, WA | |
| 1921 | L | Washington | 3 | California | 72 | Berkeley, CA | |
| 1921 | W | Washington & Jefferson (PA) | 14 | Bethany (WV) | 0 | Bethany, WV | |
| 1921 | W | Washington & Jefferson (PA) | 14 | Carnegie Mellon (PA) | 0 | Washington, PA | |
| 1921 | W | Washington & Jefferson (PA) | 14 | Lehigh (PA) | 7 | Bethlehem, PA | |
| 1921 | W | Washington & Jefferson (PA) | 17 | Syracuse (NY) | 10 | Syracuse, NY | |
| 1921 | W | Washington & Jefferson (PA) | 13 | West Virginia | 0 | Morgantown, WV | |
| 1921 | W | Washington & Jefferson (PA) | 26 | Bucknell (PA) | 0 | Washington, PA | |
| 1921 | W | Washington & Jefferson (PA) | 14 | Detroit (MI) | 2 | Detroit, MI | |
| 1921 | W | Washington & Jefferson (PA) | 49 | Westminster (PA) | 14 | New Wilmington, PA | |
| 1921 | W | Washington & Jefferson (PA) | 54 | West Virginia Wesleyan | 0 | Washington, PA | |
| 1921 | W | Washington & Jefferson (PA) | 7 | Pittsburgh (PA) | 0 | Pittsburgh, PA | |
| 1921 | T | Washington & Jefferson B Team (PA) | 0 | Kiski Academy (PA) | 0 | ? | |
| 1921 | L | Washington & Lee (VA) | 0 | Centre (KY) | 25 | Louisville, KY | |
| 1921 | W | Washington & Lee (VA) | 33 | Charleston (WV) | 7 | Lexington, VA | |
| 1921 | W | Washington & Lee (VA) | 7 | Johns Hopkins (MD) | 0 | Baltimore, MD | |
| 1921 | L | Washington & Lee (VA) | 13 | Rutgers (NJ) | 14 | New Brunswick, NJ | |
| 1921 | W | Washington & Lee (VA) | 3 | Virginia Tech | 0 | Lynchburg, VA | |
| 1921 | W | Washington & Lee (VA) | 41 | Randolph-Macon (VA) | 0 | Lexington, VA | |
| 1921 | L | Washington & Lee (VA) | 7 | West Virginia | 28 | Charleston, WV | |
| 1921 | W | Washington & Lee (VA) | 27 | Emory & Henry (VA) | 0 | Lexington, VA | |
| 1921 | W | Washington & Lee (VA) | 41 | Roanoke (VA) | 0 | Lexington, VA | |
| 1921 | L | Washington & Lee Freshmen (VA) | 0 | Fishburne Military School (VA) | 7 | ? | |
| 1921 | W | Washington & Lee Freshmen (VA) | 14 | Roanoke HS (VA) | 0 | ? | |
| 1921 | L | Washington & Lee Freshmen (VA) | 0 | Staunton Military Academy (VA) | 26 | ? | |
| 1921 | L | Washington (MD) | 0 | Delaware | 47 | Newark, DE | |
| 1921 | T | Washington (MD) | 0 | McDaniel College (MD) | 0 | Westminster, MD | |
| 1921 | L | Washington (MD) | 7 | Widener (PA) | 26 | Chester, PA | |
| 1921 | L | Washington (MD) | 0 | Fordham (NY) | 101 | New York, NY | |
| 1921 | L | Washington (MD) | 0 | George Washington (DC) | 56 | Chestertown, MD | |
| 1921 | L | Washington (MD) | 7 | Saint John's (MD) | 58 | Chestertown, MD | |
| 1921 | W | Washington (MO) | 14 | Grinnell (IA) | 13 | Grinnell, IA | |
| 1921 | W | Washington (MO) | 2 | Iowa St. | 0 | Saint Louis, MO | |
| 1921 | L | Washington (MO) | 13 | Oklahoma | 28 | Norman, OK | |
| 1921 | T | Washington (MO) | 0 | Saint Louis (MO) | 0 | Saint Louis, MO | |
| 1921 | W | Washington (MO) | 10 | Missouri S&T | 0 | Saint Louis, MO | |
| 1921 | L | Washington (MO) | 0 | Missouri | 7 | Saint Louis, MO | |
| 1921 | L | Washington (MO) | 0 | Kansas St. | 21 | Manhattan, KS | |
| 1921 | W | Washington (MO) | 14 | Tulane (LA) | 6 | Saint Louis, MO | |
| 1921 | W | Washington Business HS (DC) | 60 | Rock Hill College (MD) | 0 | ? | |
| 1921 | L | Washington Business HS (DC) | 0 | Washington Central HS (DC) | 7 | ? | |
| 1921 | L | Washington Business HS (DC) | 0 | Washington Technical HS (DC) | 21 | ? | |
| 1921 | W | Washington Central HS (DC) | 27 | Baltimore Poly HS (MD) | 7 | ? | |
| 1921 | W | Washington Central HS (DC) | 10 | Maryland Freshmen | 0 | ? | |
| 1921 | W | Washington Central HS (DC) | 7 | Shenandoah Military Academy (VA) | 2 | ? | |
| 1921 | W | Washington Central HS (DC) | 7 | Washington Business HS (DC) | 0 | ? | |
| 1921 | W | Washington Central HS (DC) | 6 | Washington Eastern HS (DC) | 3 | ? | |
| 1921 | W | Washington Central HS (DC) | 7 | Washington Technical HS (DC) | 6 | ? | |
| 1921 | T | Washington Central HS (DC) | 0 | Washington Western HS (DC) | 0 | ? | |
| 1921 | W | Washington Central HS (DC) | 27 | Charlotte Hall Military Academy (MD) | 0 | Washington, DC | |
| 1921 | L | Washington College Academy (TN) | 0 | East Tennessee St. | 42 | ? | |
| 1921 | L | Washington College Academy (TN) | 0 | King College (TN) | 54 | Bristol, TN | |
| 1921 | L | Washington Court House HS (OH) | 0 | Chillicothe HS (OH) | 33 | ? | |
| 1921 | L | Washington Court House HS (OH) | 0 | Springfield HS (OH) | 41 | ? | |
| 1921 | L | Washington Court House HS (OH) | 0 | Wilmington HS (OH) | 41 | ? | |
| 1921 | T | Washington Court House HS (OH) | 0 | Wilmington HS (OH) | 0 | ? | |
| 1921 | L | Washington Court House HS (OH) | 0 | Xenia Central HS (OH) | 27 | ? | |
| 1921 | W | Washington Dunbar HS (DC) | 6 | Armstrong HS | 0 | ? | |
| 1921 | W | Washington Dunbar HS (DC) | 24 | Baltimore City College (MD) | 0 | ? | |
| 1921 | W | Washington Dunbar HS (DC) | 13 | Cheyney (PA) | 6 | ? | |
| 1921 | W | Washington Dunbar HS (DC) | 6 | Naval Gun. Fac. | 0 | ? | |
| 1921 | L | Washington Dunbar HS (DC) | 0 | Stover College | 14 | ? | |
| 1921 | W | Washington Dunbar HS (DC) | 6 | USS Cumberland | 0 | ? | |
| 1921 | L | Washington Eastern HS (DC) | 0 | Philadelphia Catholic HS (PA) | 6 | ? | |
| 1921 | L | Washington Eastern HS (DC) | 3 | Washington Central HS (DC) | 6 | ? | |
| 1921 | L | Washington Eastern HS (DC) | 7 | Washington Technical HS (DC) | 28 | ? | |
| 1921 | T | Washington Freshmen | 7 | Everett HS (WA) | 7 | ? | |
| 1921 | W | Washington Freshmen | 30 | Saint Martin's (WA) | 0 | ? | |
| 1921 | W | Washington Freshmen | 14 | Western Washington | 0 | Bellingham, WA | |
| 1921 | W | Washington Freshmen | 31 | Central Washington | 0 | Ellensburg, WA | |
| 1921 | W | Washington Freshmen (MO) | 28 | Principia Academy (MO) | 0 | ? | |
| 1921 | T | Washington HS | 0 | Astoria HS (OR) | 0 | ? | |
| 1921 | W | Washington HS | 12 | Clinton HS (NJ) | 7 | ? | |
| 1921 | L | Washington HS | 13 | Clinton HS (NJ) | 20 | ? | |
| 1921 | W | Washington HS | 28 | Hackettstown HS (NJ) | 0 | ? | |
| 1921 | W | Washington HS | 13 | Hackettstown HS (NJ) | 0 | ? | |
| 1921 | T | Washington HS | 0 | San Rafael HS (CA) | 0 | ? | |
| 1921 | L | Washington HS (GA) | 0 | Athens HS (GA) | 66 | ? | |
| 1921 | L | Washington HS (PA) | 6 | Bellaire HS (OH) | 7 | ? | |
| 1921 | W | Washington HS (PA) | 72 | Canonsburg HS (PA) | 0 | ? | |
| 1921 | W | Washington HS (PA) | 92 | Charleroi HS (PA) | 0 | ? | |
| 1921 | W | Washington HS (PA) | 45 | Connellsville HS (PA) | 0 | ? | |
| 1921 | W | Washington HS (PA) | 20 | Donora HS (PA) | 13 | ? | |
| 1921 | W | Washington HS (PA) | 32 | Erie Central HS (PA) | 0 | ? | |
| 1921 | W | Washington HS (PA) | 41 | Latrobe HS (PA) | 0 | ? | |
| 1921 | W | Washington HS (PA) | 19 | Pittsburgh Allegheny HS (PA) | 0 | ? | |
| 1921 | W | Washington HS (PA) | 26 | Tarentum HS (PA) | 0 | ? | |
| 1921 | W | Washington HS (PA) | 31 | Waynesburg HS (PA) | 7 | ? | |
| 1921 | L | Washington Irving HS | 21 | Drum Hill HS (NY) | 24 | ? | |
| 1921 | L | Washington Irving HS | 0 | Port Chester HS (NY) | 13 | ? | |
| 1921 | L | Washington Irving HS (WV) | 7 | Buckhannon HS (WV) | 13 | ? | |
| 1921 | W | Washington Irving HS (WV) | 44 | Cameron HS (WV) | 0 | ? | |
| 1921 | W | Washington Irving HS (WV) | 35 | Clarksburg Victory HS (WV) | 0 | ? | |
| 1921 | W | Washington Irving HS (WV) | 26 | Fairmont HS (WV) | 0 | ? | |
| 1921 | W | Washington Irving HS (WV) | 27 | Grafton HS (WV) | 7 | ? | |
| 1921 | W | Washington Irving HS (WV) | 14 | Huntington HS (WV) | 13 | ? | |
| 1921 | W | Washington Irving HS (WV) | 13 | Pennsboro HS (WV) | 0 | ? | |
| 1921 | W | Washington Irving HS (WV) | 13 | West Union HS (WV) | 0 | ? | |
| 1921 | L | Washington Irving HS (WV) | 13 | Wheeling HS (WV) | 29 | ? | |
| 1921 | L | Washington St. | 0 | California | 14 | Portland, OR | |
| 1921 | W | Washington St. | 54 | Gonzaga (WA) | 7 | Spokane, WA | |
| 1921 | W | Washington St. | 20 | Idaho | 3 | Pullman, WA | |
| 1921 | W | Washington St. | 14 | Washington | 0 | Seattle, WA | |
| 1921 | L | Washington St. | 7 | Southern California | 28 | Pasadena, CA | |
| 1921 | T | Washington St. | 7 | Oregon | 7 | Pullman, WA | |
| 1921 | W | Washington St. | 7 | Oregon St. | 3 | Corvallis, OR | |
| 1921 | W | Washington St. Freshmen | 28 | Eastern Washington | 0 | Cheney, WA | |
| 1921 | W | Washington Technical HS (DC) | 7 | Alexandria Episcopal HS (VA) | 0 | ? | |
| 1921 | W | Washington Technical HS (DC) | 60 | Army & Navy Prep School (DC) | 0 | ? | |
| 1921 | W | Washington Technical HS (DC) | 14 | Maryland Freshmen | 0 | ? | |
| 1921 | W | Washington Technical HS (DC) | 12 | Newport News Apprentice School (VA) | 3 | ? | |
| 1921 | L | Washington Technical HS (DC) | 13 | Virginia Freshmen | 21 | ? | |
| 1921 | W | Washington Technical HS (DC) | 21 | Washington Business HS (DC) | 0 | ? | |
| 1921 | L | Washington Technical HS (DC) | 6 | Washington Central HS (DC) | 7 | ? | |
| 1921 | W | Washington Technical HS (DC) | 28 | Washington Eastern HS (DC) | 7 | ? | |
| 1921 | W | Washington Technical HS (DC) | 27 | Washington Western HS (DC) | 7 | ? | |
| 1921 | L | Washington Western HS (DC) | 0 | Army & Navy Prep School (DC) | 13 | ? | |
| 1921 | T | Washington Western HS (DC) | 0 | Washington Central HS (DC) | 0 | ? | |
| 1921 | L | Washington Western HS (DC) | 7 | Washington Technical HS (DC) | 27 | ? | |
| 1921 | L | Water Valley HS (MS) | 0 | Grenada HS (MS) | 26 | ? | |
| 1921 | L | Water Valley HS (MS) | 0 | Grenada HS (MS) | 21 | ? | |
| 1921 | W | Waterloo East HS (IA) | 41 | Cedar Falls HS (IA) | 7 | ? | |
| 1921 | L | Waterloo East HS (IA) | 3 | Cedar Rapids HS (IA) | 14 | ? | |
| 1921 | T | Waterloo East HS (IA) | 0 | Des Moines North HS (IA) | 0 | ? | |
| 1921 | W | Waterloo East HS (IA) | 21 | Dubuque HS (IA) | 0 | ? | |
| 1921 | W | Waterloo East HS (IA) | 105 | Independence HS (IA) | 0 | ? | |
| 1921 | W | Waterloo East HS (IA) | 13 | Iowa Falls HS (IA) | 7 | ? | |
| 1921 | T | Waterloo East HS (IA) | 0 | Marshalltown HS (IA) | 0 | ? | |
| 1921 | W | Waterloo East HS (IA) | 13 | Oelwein HS (IA) | 0 | ? | |
| 1921 | W | Waterloo East HS (IA) | 10 | Teachers College HS | 0 | ? | |
| 1921 | W | Waterloo HS (WI) | 1 | Watertown HS (WI) | 0 | ? | Watertown HS Forfeits |
| 1921 | L | Waterloo West HS (IA) | 6 | Cedar Rapids HS (IA) | 22 | ? | |
| 1921 | L | Waterloo West HS (IA) | 0 | Osage HS (IA) | 17 | ? | |
| 1921 | W | Watertown HS (MA) | 7 | Dedham HS (MA) | 6 | ? | |
| 1921 | W | Watertown HS (MA) | 13 | Melrose HS (MA) | 0 | ? | |
| 1921 | T | Watertown HS (MA) | 7 | Wakefield HS (MA) | 7 | ? | |
| 1921 | L | Watertown HS (MA) | 0 | Woburn HS (MA) | 33 | ? | |
| 1921 | L | Watertown HS (NY) | 0 | Binghamton Central HS (NY) | 41 | ? | |
| 1921 | W | Watertown HS (SD) | 13 | Clark HS (SD) | 7 | ? | |
| 1921 | L | Watervliet HS (NY) | 0 | Albany Academy (NY) | 9 | ? | |
| 1921 | L | Watervliet HS (NY) | 0 | Albany HS (NY) | 27 | ? | |
| 1921 | L | Watervliet HS (NY) | 0 | Gloversville HS (NY) | 20 | ? | |
| 1921 | T | Watseka HS (IL) | 7 | Danville HS (IL) | 7 | ? | |
| 1921 | L | Watsonville HS (CA) | 0 | Salinas HS (CA) | 72 | ? | |
| 1921 | L | Watsonville HS (CA) | 0 | Santa Clara University HS (CA) | 54 | ? | |
| 1921 | L | Watsonville HS (CA) | 6 | Santa Cruz HS (CA) | 42 | ? | |
| 1921 | L | Waukegan HS (IL) | 0 | Deerfield Shields HS (IL) | 21 | ? | |
| 1921 | L | Waukesha HS (WI) | 0 | Kenosha HS (WI) | 6 | ? | |
| 1921 | L | Waupun HS (WI) | 0 | Watertown HS (WI) | 26 | ? | |
| 1921 | L | Waverly HS (IL) | 0 | Jacksonville HS (IL) | 49 | ? | |
| 1921 | W | Waverly HS (IL) | 15 | Pittsfield HS (IL) | 6 | ? | |
| 1921 | W | Waverly HS (NY) | 7 | Cook Academy (NY) | 6 | ? | |
| 1921 | W | Waverly HS (PA) | 14 | Athens HS (PA) | 0 | ? | |
| 1921 | W | Waverly HS (PA) | 6 | Athens HS (PA) | 0 | ? | |
| 1921 | W | Wawatosa HS | 71 | Country Day School (WI) | 6 | ? | |
| 1921 | W | Wayland Academy (WI) | 12 | Country Day School (WI) | 0 | ? | |
| 1921 | W | Wayland Academy (WI) | 46 | Horicon HS (WI) | 0 | ? | |
| 1921 | W | Wayland Academy (WI) | 7 | Mayville HS (WI) | 0 | ? | |
| 1921 | L | Wayland Academy (WI) | 0 | Milwaukee South Division HS (WI) | 23 | ? | |
| 1921 | L | Wayland Academy (WI) | 14 | Northwestern (WI) | 26 | ? | |
| 1921 | W | Wayland Academy (WI) | 20 | Ripon HS (WI) | 0 | ? | |
| 1921 | L | Wayland Baptist (TX) | 0 | West Texas A&M | 68 | Canyon, TX | |
| 1921 | L | Wayland Baptist (TX) | 0 | Clarendon College (TX) | 34 | Plainview, TX | |
| 1921 | L | Wayne HS (MI) | 6 | Ann Arbor HS (MI) | 12 | ? | |
| 1921 | W | Wayne St. (MI) | 26 | Assumption College (ON) | 0 | Windsor, ON (Canada) | |
| 1921 | W | Wayne St. (MI) | 28 | Baldwin-Wallace (OH) | 0 | Detroit, MI | |
| 1921 | T | Wayne St. (MI) | 0 | Central Michigan | 0 | Detroit, MI | |
| 1921 | W | Wayne St. (MI) | 3 | Eastern Michigan | 0 | Detroit, MI | |
| 1921 | W | Wayne St. (MI) | 13 | Toledo (OH) | 0 | Toledo, OH | |
| 1921 | W | Wayne St. (MI) | 26 | Olivet (MI) | 0 | Detroit, MI | |
| 1921 | T | Wayne St. (MI) | 0 | Alma (MI) | 0 | Detroit, MI | |
| 1921 | W | Wayne St. (MI) | 39 | Grand Rapids JC (MI) | 0 | Detroit, MI | |
| 1921 | W | Wayne St. (NE) | 33 | Chadron St. (NE) | 12 | ? | |
| 1921 | W | Wayne St. (NE) | 14 | Grand Island College (NE) | 0 | Wayne, NE | |
| 1921 | W | Wayne St. (NE) | 7 | Midland Lutheran (NE) | 0 | ? | |
| 1921 | L | Wayne St. (NE) | 0 | Morningside (IA) | 49 | ? | |
| 1921 | W | Wayne St. (NE) | 47 | Nebraska Central | 12 | ? | |
| 1921 | W | Wayne St. (NE) | 6 | Peru St. (NE) | 0 | ? | |
| 1921 | L | Wayne St. (NE) | 3 | Nebraska Wesleyan | 17 | Lincoln, NE | State Championship |
| 1921 | W | Wayne St. (NE) | 14 | Westmar (IA) | 7 | Wayne, NE | |
| 1921 | L | Waynesboro Business College (PA) | 0 | Lancaster HS (PA) | 49 | ? | |
| 1921 | T | Waynesboro Business School (VA) | 7 | Shepherd (WV) | 7 | Waynesboro, VA | |
| 1921 | W | Waynesburg (PA) | 21 | California (PA) | 0 | ? | |
| 1921 | W | Waynesburg (PA) | 13 | California (PA) | 0 | ? | |
| 1921 | W | Waynesburg (PA) | 13 | Carnegie Mellon JV (PA) | 0 | ? | |
| 1921 | L | Waynesburg (PA) | 14 | Fairmont St. (WV) | 17 | ? | |
| 1921 | W | Waynesburg HS (PA) | 7 | Cameron HS (WV) | 0 | ? | |
| 1921 | L | Waynesburg HS (PA) | 7 | Morgantown HS (WV) | 14 | ? | |
| 1921 | L | Waynesburg HS (PA) | 7 | Washington HS (PA) | 31 | ? | |
| 1921 | W | Wayzata HS (MN) | 21 | Phalen Luther Seminary (MN) | 13 | ? | |
| 1921 | L | Weatherford (TX) | 6 | John Tarleton College (TX) | 49 | ? | |
| 1921 | W | Weaver College (NC) | 7 | Asheville School (NC) | 2 | ? | |
| 1921 | W | Weaver College (NC) | 21 | Bingham Military School (NC) | 14 | Asheville, NC | |
| 1921 | L | Weaver College (NC) | 0 | Carson-Newman (TN) | 18 | Jefferson City, TN | |
| 1921 | L | Weaver College (NC) | 0 | Charlotte University School (NC) | 3 | ? | |
| 1921 | W | Weaver College (NC) | 21 | Mars Hill JC (NC) | 0 | ? | |
| 1921 | W | Weaver College (NC) | 13 | Mars Hill JC (NC) | 9 | ? | |
| 1921 | L | Webb City HS (MO) | 0 | Joplin HS (MO) | 48 | ? | |
| 1921 | L | Weber JC (UT) | 7 | Ogden HS (UT) | 22 | ? | |
| 1921 | W | Weber JC (UT) | 21 | Westminster College (UT) | 7 | ? | |
| 1921 | L | Weber JC (UT) | 0 | Brigham Young College (UT) | 7 | ? | |
| 1921 | T | Webster Groves HS (MO) | 0 | Alton HS (IL) | 0 | ? | |
| 1921 | W | Webster Groves HS (MO) | 28 | Clayton HS (MO) | 0 | ? | |
| 1921 | W | Webster Groves HS (MO) | 7 | Kirkwood HS (MO) | 6 | ? | |
| 1921 | W | Webster Groves HS (MO) | 7 | Maplewood HS (MO) | 0 | ? | |
| 1921 | W | Webster Groves HS (MO) | 13 | Saint Charles HS (MO) | 7 | ? | |
| 1921 | W | Webster Groves HS (MO) | 7 | Saint Louis East HS (MO) | 0 | ? | |
| 1921 | W | Webster Groves HS (MO) | 7 | University City HS (MO) | 0 | ? | |
| 1921 | L | Webster Groves HS (MO) | 0 | Webster Groves HS Alumni (MO) | 14 | ? | |
| 1921 | L | Webster HS (SD) | 0 | Clark HS (SD) | 50 | ? | |
| 1921 | L | Wellington HS (KS) | 0 | Kingman HS (KS) | 50 | ? | |
| 1921 | L | Wells HS (MN) | 0 | Mankato HS (MN) | 48 | ? | |
| 1921 | T | Wellsboro HS (PA) | 0 | South Hills HS (PA) | 0 | ? | |
| 1921 | T | Wellsburg HS (WV) | 0 | Cameron HS (WV) | 0 | ? | |
| 1921 | L | Wellsburg HS (WV) | 0 | Follansbee HS (WV) | 7 | ? | |
| 1921 | W | Wellsburg HS (WV) | 7 | Sistersville HS (WV) | 0 | ? | |
| 1921 | L | Wenatchee HS (WA) | 7 | Everett HS (WA) | 48 | ? | |
| 1921 | L | Wendell HS (ID) | 0 | Twin Falls HS (ID) | 133 | ? | |
| 1921 | L | Wendell HS (ID) | 7 | Twin Falls HS (ID) | 28 | ? | |
| 1921 | W | Wenonah Military Academy (NJ) | 20 | Bridgeton HS (NJ) | 0 | ? | |
| 1921 | L | Wenonah Military Academy (NJ) | 7 | Bryn Athyn HS (PA) | 19 | ? | |
| 1921 | L | Wenonah Military Academy (NJ) | 0 | La Salle Prep School (PA) | 18 | ? | |
| 1921 | T | Wenonah Military Academy (NJ) | 0 | Pennington Seminary (NJ) | 0 | ? | |
| 1921 | T | Wenonah Military Academy (NJ) | 7 | Philadelphia West Catholic HS (PA) | 7 | ? | |
| 1921 | T | Wenonah Military Academy (NJ) | 13 | Woodbury HS (NJ) | 13 | ? | |
| 1921 | W | Wentworth Military Academy (MO) | 53 | Central Inelig. | 13 | ? | |
| 1921 | T | Wentworth Military Academy (MO) | 6 | Central Missouri St. | 6 | Warrensburg, MO | |
| 1921 | L | Wentworth Military Academy (MO) | 0 | Chillicothe Business College (MO) | 14 | Chillicothe, MO | |
| 1921 | L | Wentworth Military Academy (MO) | 0 | Kansas City (KS) | 21 | ? | |
| 1921 | L | Wentworth Military Academy (MO) | 0 | Kemper Military School (MO) | 13 | ? | |
| 1921 | T | Wentworth Military Academy (MO) | 7 | Missouri Valley | 7 | ? | |
| 1921 | L | Wentworth Military Academy (MO) | 0 | Missouri Military Academy | 2 | ? | |
| 1921 | W | Wesley College (TX) | 28 | Burleson College (TX) | 0 | ? | |
| 1921 | T | Wesley College (TX) | 7 | Dallas (TX) | 7 | ? | |
| 1921 | L | Wesley College (TX) | 6 | North Texas | 33 | ? | |
| 1921 | W | Wesley College (TX) | 17 | Rusk Baptist College (TX) | 7 | ? | |
| 1921 | L | Wesley College (TX) | 7 | Texas A&M-Commerce | 13 | Greenville, TX | |
| 1921 | L | Wesley College (TX) | 0 | Texas Freshmen | 28 | ? | |
| 1921 | T | Wesley College (TX) | 0 | Texas Military College | 0 | ? | |
| 1921 | L | Wesley College (TX) | 0 | Texas-Arlington | 28 | ? | |
| 1921 | L | Wesley College (TX) | 0 | Trinity (TX) | 35 | ? | |
| 1921 | L | Wesleyan (CT) | 0 | Boston (MA) | 7 | Middletown, CT | |
| 1921 | T | Wesleyan (CT) | 7 | New York (NY) | 7 | New York, NY | Ohio Field |
| 1921 | T | Wesleyan (CT) | 14 | Tufts (MA) | 14 | Middletown, CT | |
| 1921 | L | Wesleyan (CT) | 0 | Williams (MA) | 40 | Middletown, CT | |
| 1921 | W | Wesleyan (CT) | 13 | Stevens Tech (NJ) | 0 | Middletown, CT | |
| 1921 | T | Wesleyan (CT) | 3 | Amherst (MA) | 3 | Amherst, MA | |
| 1921 | L | Wesleyan (CT) | 3 | Columbia (NY) | 14 | Middletown, CT | |
| 1921 | L | Wesleyan (CT) | 0 | Union (NY) | 7 | Schenectady, NY | |
| 1921 | L | West Alexandria HS (OH) | 7 | Xenia Central HS (OH) | 21 | ? | |
| 1921 | L | West Central School of Agriculture (MN) | 0 | Glenwood HS (MN) | 86 | ? | |
| 1921 | L | West Chester (PA) | 7 | Millersville (PA) | 38 | West Chester, PA | |
| 1921 | T | West Chester (PA) | 7 | Moravian Prep | 7 | West Chester, PA | |
| 1921 | W | West Chester (PA) | 21 | Perkiomen Seminary (PA) | 7 | Pennsburg, PA | |
| 1921 | W | West Chester (PA) | 20 | Williamson Trade School (PA) | 14 | West Chester, PA | |
| 1921 | L | West Chester (PA) | 7 | Shippensburg (PA) | 63 | Shippensburg, PA | |
| 1921 | L | West Chester (PA) | 7 | Pennsylvania Freshmen | 24 | Philadelphia, PA | |
| 1921 | L | West Chester (PA) | 0 | Schuylkill College (PA) | 20 | West Chester, PA | |
| 1921 | L | West Chester HS (PA) | 6 | Berwyn HS (PA) | 7 | ? | |
| 1921 | L | West Chester HS (PA) | 6 | Chester HS (PA) | 7 | ? | |
| 1921 | L | West Chester HS (PA) | 0 | Coatesville HS (PA) | 6 | ? | |
| 1921 | W | West Chester HS (PA) | 32 | Palmyra HS (NJ) | 3 | ? | |
| 1921 | W | West Chester HS (PA) | 47 | Parkesburg HS (PA) | 6 | ? | |
| 1921 | L | West Chester HS (PA) | 3 | Philadelphia Catholic HS (PA) | 6 | ? | |
| 1921 | L | West Chester HS (PA) | 7 | Phoenixville HS (PA) | 21 | ? | |
| 1921 | L | West Chester HS (PA) | 6 | Wilmington HS (DE) | 7 | ? | |
| 1921 | L | West Haven HS (CT) | 0 | Ansonia HS (CT) | 14 | ? | |
| 1921 | L | West Lafayette | 0 | Saint Joseph's (IN) | 1 | ? | West Lafayette Forfeits |
| 1921 | L | West Newton HS (PA) | 0 | Duquesne HS (PA) | 62 | ? | |
| 1921 | T | West Orange HS (NJ) | 0 | Bernards HS (NJ) | 0 | ? | |
| 1921 | L | West Orange HS (NJ) | 0 | Brooklyn Evening HS (NY) | 20 | ? | |
| 1921 | L | West Orange HS (NJ) | 0 | Chatham HS (NJ) | 7 | ? | |
| 1921 | L | West Orange HS (NJ) | 0 | Irvington HS (NJ) | 21 | ? | |
| 1921 | W | West Orange HS (NJ) | 14 | Montclair HS JV (NJ) | 7 | ? | |
| 1921 | L | West Orange HS (NJ) | 0 | Orange HS (NJ) | 41 | ? | |
| 1921 | L | West Orange HS (NJ) | 7 | Roselle Park HS (NJ) | 12 | ? | |
| 1921 | T | West Orange HS (NJ) | 0 | Rutherford East HS (NJ) | 0 | ? | |
| 1921 | L | West Orange HS (NJ) | 0 | South Orange Columbia HS (NJ) | 14 | ? | |
| 1921 | L | West Seattle HS (WA) | 0 | Seattle Ballard HS (WA) | 13 | ? | |
| 1921 | W | West Seattle HS (WA) | 14 | Seattle Broadway HS (WA) | 0 | ? | |
| 1921 | L | West Seattle HS (WA) | 0 | Seattle Franklin HS (WA) | 16 | ? | |
| 1921 | L | West Seattle HS (WA) | 6 | Seattle Queen Anne HS (WA) | 13 | ? | |
| 1921 | W | West Texas A&M | 35 | Abilene Christian (TX) | 0 | Canyon, TX | |
| 1921 | L | West Texas A&M | 0 | Clarendon College (TX) | 9 | Clarendon, TX | |
| 1921 | T | West Texas A&M | 14 | Clarendon College (TX) | 14 | Canyon, TX | |
| 1921 | L | West Texas A&M | 10 | New Mexico Military Institute | 19 | Roswell, NM | |
| 1921 | L | West Texas A&M | 7 | Northwestern Oklahoma St. | 14 | Canyon, TX | |
| 1921 | L | West Texas A&M | 0 | Texas Christian | 30 | Canyon, TX | |
| 1921 | W | West Texas A&M | 68 | Wayland Baptist (TX) | 0 | Canyon, TX | |
| 1921 | L | West Texas A&M | 0 | Hardin-Simmons (TX) | 28 | Abilene, TX | |
| 1921 | L | West Texas Military Academy | 7 | San Marcos Baptist (TX) | 62 | ? | |
| 1921 | W | West Union HS (WV) | 21 | Cairo HS (WV) | 0 | ? | |
| 1921 | W | West Union HS (WV) | 44 | Cairo HS (WV) | 0 | ? | |
| 1921 | W | West Union HS (WV) | 21 | Fairmont East Side HS (WV) | 7 | ? | |
| 1921 | L | West Union HS (WV) | 0 | Mannington HS (WV) | 44 | ? | |
| 1921 | W | West Union HS (WV) | 34 | Pullman HS (WV) | 0 | ? | |
| 1921 | W | West Union HS (WV) | 48 | Salem HS (WV) | 0 | ? | |
| 1921 | W | West Union HS (WV) | 46 | Salem HS (WV) | 0 | ? | |
| 1921 | W | West Union HS (WV) | 45 | Shinnston HS (WV) | 0 | ? | |
| 1921 | L | West Union HS (WV) | 7 | Spencer HS (WV) | 35 | ? | |
| 1921 | L | West Union HS (WV) | 0 | Washington Irving HS (WV) | 13 | ? | |
| 1921 | T | West Virginia | 0 | Bucknell (PA) | 0 | Morgantown, WV | |
| 1921 | L | West Virginia | 14 | Lehigh (PA) | 21 | Bethlehem, PA | |
| 1921 | W | West Virginia | 7 | Ohio | 0 | Morgantown, WV | |
| 1921 | L | West Virginia | 7 | Rutgers (NJ) | 17 | New Brunswick, NJ | |
| 1921 | L | West Virginia | 0 | Washington & Jefferson (PA) | 13 | Morgantown, WV | |
| 1921 | W | West Virginia | 34 | West Virginia Wesleyan | 3 | Fairmont, WV | |
| 1921 | W | West Virginia | 50 | Cincinnati (OH) | 0 | Morgantown, WV | |
| 1921 | W | West Virginia | 28 | Washington & Lee (VA) | 7 | Charleston, WV | |
| 1921 | L | West Virginia | 14 | Pittsburgh (PA) | 21 | Pittsburgh, PA | |
| 1921 | W | West Virginia | 7 | Virginia | 0 | Charlottesville, VA | |
| 1921 | W | West Virginia B Team | 28 | Broaddus College (WV) | 0 | ? | |
| 1921 | W | West Virginia B Team | 35 | Glenville St. (WV) | 0 | ? | |
| 1921 | L | West Virginia Freshmen | 0 | Davis & Elkins (WV) | 40 | ? | |
| 1921 | W | West Virginia Freshmen | 35 | Fairmont St. (WV) | 21 | ? | |
| 1921 | L | West Virginia Freshmen | 0 | Kiski Academy (PA) | 38 | ? | |
| 1921 | W | West Virginia St. | 73 | Bluefield St. (WV) | 0 | ? | |
| 1921 | L | West Virginia St. | 0 | Howard (DC) | 3 | ? | |
| 1921 | W | West Virginia St. | 41 | Kentucky St. | 0 | ? | |
| 1921 | W | West Virginia St. | 40 | Simmons (KY) | 0 | ? | |
| 1921 | L | West Virginia St. | 0 | Virginia-Lynchburg | 3 | ? | |
| 1921 | W | West Virginia St. | 14 | Wilberforce (OH) | 0 | Institute, WV | |
| 1921 | W | West Virginia Tech | 42 | Alderson (WV) | 3 | ? | |
| 1921 | L | West Virginia Tech | 0 | Charleston (WV) | 21 | ? | |
| 1921 | W | West Virginia Tech | 40 | Concord (WV) | 0 | ? | |
| 1921 | W | West Virginia Tech | 7 | Marshall (WV) | 0 | ? | |
| 1921 | W | West Virginia Tech | 28 | Mullens American Legion (WV) | 0 | ? | |
| 1921 | T | West Virginia Tech | 0 | Potomac St. (WV) | 0 | ? | |
| 1921 | L | West Virginia Tech | 0 | Rio Grande (OH) | 21 | ? | |
| 1921 | L | West Virginia Tech | 0 | Spencer HS (WV) | 7 | ? | |
| 1921 | L | West Virginia Wesleyan | 0 | Bethany (WV) | 67 | Wheeling, WV | |
| 1921 | L | West Virginia Wesleyan | 0 | Detroit (MI) | 55 | Detroit, MI | |
| 1921 | L | West Virginia Wesleyan | 0 | Marietta (OH) | 20 | Marietta, OH | |
| 1921 | L | West Virginia Wesleyan | 0 | Salem College (WV) | 7 | ? | |
| 1921 | L | West Virginia Wesleyan | 3 | West Virginia | 34 | Fairmont, WV | |
| 1921 | L | West Virginia Wesleyan | 0 | Washington & Jefferson (PA) | 54 | Washington, PA | |
| 1921 | L | West Virginia Wesleyan | 0 | Grove City (PA) | 28 | Grove City, PA | |
| 1921 | L | Westboro HS (MA) | 0 | Hudson HS (MA) | 24 | ? | |
| 1921 | L | Westerly HS (RI) | 0 | Harford Bulkeley HS (CT) | 7 | ? | |
| 1921 | W | Westerly HS (RI) | 1 | Harford Bulkeley HS (CT) | 0 | ? | |
| 1921 | W | Westerly HS (RI) | 20 | Kingston HS (RI) | 7 | ? | |
| 1921 | L | Westerly HS (RI) | 0 | New London Vocational HS (CT) | 13 | ? | |
| 1921 | L | Westerly HS (RI) | 7 | New London Vocational HS (CT) | 13 | ? | |
| 1921 | L | Westerly HS (RI) | 6 | Norwich Academy (CT) | 7 | ? | |
| 1921 | W | Westerly HS (RI) | 12 | Norwich Academy (CT) | 0 | ? | |
| 1921 | W | Westerly HS (RI) | 1 | Stonington HS (CT) | 0 | ? | |
| 1921 | W | Westerly HS (RI) | 21 | Warwick HS | 6 | ? | |
| 1921 | T | Westerly HS (RI) | 12 | Westerly HS Alumni (RI) | 12 | ? | |
| 1921 | T | Westerly HS Alumni (RI) | 12 | Westerly HS (RI) | 12 | ? | |
| 1921 | L | Western (KS) | 13 | Lincoln HS | 20 | Kansas City, MO | |
| 1921 | T | Western Illinois | 0 | Bradley JV (IL) | 0 | Macomb, IL | |
| 1921 | W | Western Illinois | 14 | Culver-Stockton (MO) | 6 | Canton, MO | |
| 1921 | W | Western Illinois | 14 | Hedding (IL) | 0 | Abingdon, IL | |
| 1921 | L | Western Illinois | 0 | Knox JV (IL) | 6 | Macomb, IL | |
| 1921 | W | Western Illinois | 14 | Quincy (IL) | 7 | Macomb, IL | |
| 1921 | L | Western Illinois | 7 | Carthage (WI) | 21 | Carthage, IL | |
| 1921 | L | Western Illinois | 7 | Carthage (WI) | 21 | Macomb, IL | |
| 1921 | T | Western Kentucky | 7 | Bethel (KY) | 7 | ? | |
| 1921 | W | Western Kentucky | 12 | Rhodes (TN) | 0 | ? | |
| 1921 | L | Western Kentucky | 0 | Vanderbilt JV (TN) | 12 | ? | |
| 1921 | L | Western Kentucky | 0 | Union (TN) | 26 | ? | |
| 1921 | W | Western Kentucky | 21 | Eastern Kentucky | 0 | Bowling Green, KY | |
| 1921 | L | Western Kentucky | 0 | Bethel (KY) | 26 | ? | |
| 1921 | L | Western Kentucky | 7 | Middle Tennessee St. | 15 | Murfreesboro, TN | |
| 1921 | L | Western Michigan | 3 | Chicago YMCA College (IL) | 7 | Kalamazoo, MI | |
| 1921 | W | Western Michigan | 42 | Earlham (IN) | 7 | Kalamazoo, MI | |
| 1921 | W | Western Michigan | 49 | Ferris St. (MI) | 0 | Kalamazoo, MI | |
| 1921 | L | Western Michigan | 14 | Michigan St. | 17 | East Lansing, MI | |
| 1921 | W | Western Michigan | 20 | Albion (MI) | 9 | Albion, MI | |
| 1921 | W | Western Michigan | 65 | Hope (MI) | 0 | Kalamazoo, MI | |
| 1921 | W | Western Michigan | 7 | Notre Dame Freshmen (IN) | 0 | Kalamazoo, MI | |
| 1921 | W | Western Michigan | 62 | Milwaukee School of Engineering (WI) | 0 | Kalamazoo, MI | |
| 1921 | W | Western Military Academy (IL) | 7 | Jacksonville HS (IL) | 0 | ? | |
| 1921 | L | Western Reserve (OH) | 7 | Akron (OH) | 14 | Akron, OH | |
| 1921 | T | Western Reserve (OH) | 0 | Case Institute of Technology (OH) | 0 | Cleveland, OH | |
| 1921 | L | Western Reserve (OH) | 0 | Cornell (NY) | 110 | Ithaca, NY | |
| 1921 | L | Western Reserve (OH) | 0 | Oberlin (OH) | 7 | Oberlin, OH | |
| 1921 | L | Western Reserve (OH) | 0 | Wittenberg (OH) | 7 | Cleveland, OH | |
| 1921 | L | Western Reserve (OH) | 0 | Wooster (OH) | 7 | Cleveland, OH | |
| 1921 | W | Western Reserve (OH) | 29 | Heidelberg (OH) | 0 | Cleveland, OH | |
| 1921 | L | Western Reserve (OH) | 0 | Ohio Northern | 6 | Ada, OH | |
| 1921 | L | Western Reserve (OH) | 0 | Navy (MD) | 53 | Annapolis, MD | |
| 1921 | W | Western Reserve (OH) | 7 | Ohio Wesleyan | 0 | Delaware, OH | |
| 1921 | W | Western Washington | 17 | Puget Sound (WA) | 6 | Bellingham, WA | |
| 1921 | W | Western Washington | 6 | Saint Martin's (WA) | 0 | Bellingham, WA | |
| 1921 | W | Western Washington | 14 | Sedro-Woolley HS (WA) | 0 | Ellensburg, WA | |
| 1921 | W | Western Washington | 28 | Torpedo Station | 0 | Bellingham, WA | |
| 1921 | L | Western Washington | 0 | Washington Freshmen | 14 | Bellingham, WA | |
| 1921 | W | Westfield HS (NJ) | 40 | Bound Brook HS (NJ) | 0 | ? | |
| 1921 | W | Westfield HS (NJ) | 32 | Cranford HS (NJ) | 0 | ? | |
| 1921 | L | Westfield HS (NJ) | 0 | Plainfield HS (NJ) | 28 | ? | |
| 1921 | L | Westfield HS (NJ) | 0 | Rahway HS (NJ) | 30 | ? | |
| 1921 | W | Westfield HS (NJ) | 15 | Roselle HS (NJ) | 0 | ? | |
| 1921 | T | Westfield HS (NJ) | 7 | Roselle Park HS (NJ) | 7 | ? | |
| 1921 | L | Westfield HS (NJ) | 7 | Somerville HS (NJ) | 12 | ? | |
| 1921 | L | Westfield HS (NJ) | 7 | Summit HS (NJ) | 12 | ? | |
| 1921 | W | Westinghouse HS (PA) | 51 | Pittsburgh 5th Ave. HS (PA) | 0 | ? | |
| 1921 | W | Westinghouse HS (PA) | 6 | Pittsburgh Allegheny HS (PA) | 0 | ? | |
| 1921 | W | Westinghouse HS (PA) | 13 | Pittsburgh Peabody HS (PA) | 7 | ? | |
| 1921 | W | Westinghouse HS (PA) | 7 | Pittsburgh South HS (PA) | 0 | ? | |
| 1921 | T | Westinghouse HS (PA) | 0 | Rochester HS (PA) | 0 | ? | |
| 1921 | W | Westinghouse HS (PA) | 20 | Schenley HS (PA) | 0 | ? | |
| 1921 | W | Westinghouse HS (PA) | 20 | South Hills HS (PA) | 7 | ? | |
| 1921 | W | Westinghouse HS (PA) | 35 | Swissvale HS (PA) | 0 | ? | |
| 1921 | W | Westmar (IA) | 10 | Buena Vista (IA) | 7 | LeMars, IA | |
| 1921 | L | Westmar (IA) | 0 | Dakota Wesleyan (SD) | 6 | LeMars, IA | |
| 1921 | L | Westmar (IA) | 7 | Ellsworth CC (IA) | 28 | Iowa Falls, IA | |
| 1921 | L | Westmar (IA) | 3 | Yankton (SD) | 28 | Yankton, SD | |
| 1921 | L | Westmar (IA) | 0 | Morningside (IA) | 9 | Sioux City, IA | |
| 1921 | L | Westmar (IA) | 7 | Wayne St. (NE) | 14 | Wayne, NE | |
| 1921 | W | Westmar (IA) | 10 | Trinity (IA) | 0 | LeMars, IA | |
| 1921 | L | Westminster (MO) | 7 | Central Methodist (MO) | 21 | ? | |
| 1921 | W | Westminster (MO) | 25 | Central Wesleyan (MO) | 0 | Warrensburg, MO | |
| 1921 | W | Westminster (MO) | 18 | Missouri Military Academy | 7 | ? | |
| 1921 | T | Westminster (MO) | 0 | Missouri Valley | 0 | ? | |
| 1921 | L | Westminster (MO) | 0 | Truman St. (MO) | 6 | Fulton, MO | |
| 1921 | L | Westminster (MO) | 0 | William Jewell (MO) | 7 | ? | |
| 1921 | L | Westminster (MO) | 0 | Missouri Wesleyan | 36 | Saint Joseph, MO | |
| 1921 | L | Westminster (MO) | 0 | Saint Louis (MO) | 36 | Saint Louis, MO | |
| 1921 | L | Westminster (PA) | 6 | Allegheny (PA) | 7 | New Wilmington, PA | |
| 1921 | L | Westminster (PA) | 0 | Georgetown (DC) | 66 | Washington, DC | |
| 1921 | L | Westminster (PA) | 0 | Grove City (PA) | 13 | New Wilmington, PA | |
| 1921 | W | Westminster (PA) | 28 | John Carroll (OH) | 21 | New Wilmington, PA | |
| 1921 | T | Westminster (PA) | 0 | Saint Bonaventure (NY) | 0 | New Wilmington, PA | |
| 1921 | L | Westminster (PA) | 0 | Baldwin-Wallace (OH) | 14 | New Wilmington, PA | |
| 1921 | L | Westminster (PA) | 14 | Washington & Jefferson (PA) | 49 | New Wilmington, PA | |
| 1921 | T | Westminster (PA) | 0 | Geneva (PA) | 0 | Beaver Falls, PA | |
| 1921 | L | Westminster (PA) | 0 | Carnegie Mellon (PA) | 42 | Pittsburgh, PA | |
| 1921 | L | Westminster College (UT) | 0 | Evanston HS (WY) | 14 | ? | |
| 1921 | L | Westminster College (UT) | 7 | Grantsville HS (UT) | 17 | ? | |
| 1921 | L | Westminster College (UT) | 0 | Jordan HS | 41 | ? | |
| 1921 | W | Westminster College (UT) | 19 | Jordan HS JV | 0 | ? | |
| 1921 | W | Westminster College (UT) | 21 | Lehi HS (UT) | 13 | ? | |
| 1921 | L | Westminster College (UT) | 0 | Park City HS (UT) | 6 | ? | |
| 1921 | L | Westminster College (UT) | 7 | Salt Lake City East Side HS (UT) | 20 | ? | |
| 1921 | L | Westminster College (UT) | 0 | Springfield HS | 7 | ? | |
| 1921 | L | Westminster College (UT) | 7 | Weber JC (UT) | 21 | ? | |
| 1921 | L | Westminster School (CT) | 0 | Hopkins Grammar School (CT) | 3 | ? | |
| 1921 | L | Weston HS (WV) | 7 | Buckhannon HS (WV) | 24 | ? | |
| 1921 | W | Weston HS (WV) | 13 | Clarksburg Victory HS (WV) | 7 | ? | |
| 1921 | W | Weston HS (WV) | 17 | Elkins HS (WV) | 14 | ? | |
| 1921 | W | Weston HS (WV) | 47 | Fairmont East Side HS (WV) | 7 | ? | |
| 1921 | T | Weston HS (WV) | 0 | Fairmont HS (WV) | 0 | ? | |
| 1921 | T | Weston HS (WV) | 6 | Grafton HS (WV) | 6 | ? | |
| 1921 | W | Weston HS (WV) | 7 | Mannington HS (WV) | 0 | ? | |
| 1921 | W | Weston HS (WV) | 21 | Morgantown HS (WV) | 0 | ? | |
| 1921 | W | Weston HS (WV) | 59 | Shinnston HS (WV) | 0 | ? | |
| 1921 | L | Wetumka HS (OK) | 0 | Tulsa Central HS (OK) | 14 | ? | |
| 1921 | L | Wheaton (IL) | 0 | Chicago YMCA College (IL) | 56 | Chicago, IL | |
| 1921 | W | Wheaton (IL) | 18 | College AEF Veterans | 0 | Wheaton, IL | |
| 1921 | W | Wheaton (IL) | 5 | Crane JC (IL) | 0 | Chicago, IL | |
| 1921 | L | Wheaton (IL) | 0 | Lake Forest (IL) | 28 | Wheaton, IL | |
| 1921 | W | Wheaton (IL) | 10 | Northern Illinois | 7 | Wheaton, IL | |
| 1921 | W | Wheaton (IL) | 40 | Elmhurst (IL) | 6 | Elmhurst, IL | |
| 1921 | W | Wheaton (IL) | 7 | Mount Morris (IL) | 6 | Mount Morris, IL | |
| 1921 | W | Wheaton (IL) | 20 | Elmhurst (IL) | 0 | Wheaton, IL | |
| 1921 | L | Wheaton HS (IL) | 0 | Toledo Scott HS (OH) | 39 | ? | |
| 1921 | L | Wheaton HS (MN) | 13 | Glenwood HS (MN) | 28 | ? | |
| 1921 | L | Wheaton HS (MO) | 0 | Joplin HS (MO) | 41 | ? | |
| 1921 | T | Wheeling HS (WV) | 0 | Bellaire HS (OH) | 0 | ? | |
| 1921 | W | Wheeling HS (WV) | 41 | Cameron HS (WV) | 6 | ? | |
| 1921 | W | Wheeling HS (WV) | 14 | Charleston HS (WV) | 7 | ? | |
| 1921 | W | Wheeling HS (WV) | 10 | Linsly Military Institute (WV) | 0 | ? | |
| 1921 | W | Wheeling HS (WV) | 6 | New Martinsville HS (WV) | 0 | ? | |
| 1921 | L | Wheeling HS (WV) | 0 | Parkersburg HS (WV) | 6 | ? | |
| 1921 | W | Wheeling HS (WV) | 20 | Richland District HS (WV) | 0 | ? | |
| 1921 | W | Wheeling HS (WV) | 29 | Washington Irving HS (WV) | 13 | ? | |
| 1921 | L | White Bear Lake HS (MN) | 7 | Stillwater HS (MN) | 20 | ? | |
| 1921 | L | White Hall HS (IL) | 7 | Jacksonville HS (IL) | 28 | ? | |
| 1921 | L | White Hall HS (IL) | 12 | Pittsfield HS (IL) | 13 | ? | |
| 1921 | W | White Plains HS (NY) | 7 | Hackley School (NY) | 0 | ? | |
| 1921 | L | White Plains HS (NY) | 7 | Irving School (NY) | 21 | ? | |
| 1921 | L | White Plains HS (NY) | 0 | Mamaroneck HS (NY) | 21 | ? | |
| 1921 | T | White Plains HS (NY) | 14 | New Rochelle HS (NY) | 14 | ? | |
| 1921 | L | White Plains HS (NY) | 0 | Newark Central HS (NJ) | 60 | ? | |
| 1921 | W | White Plains HS (NY) | 21 | Yonkers HS (NY) | 12 | ? | |
| 1921 | L | Whitehall HS (MT) | 0 | Park County HS (MT) | 61 | ? | |
| 1921 | L | Whitehall HS (MT) | 6 | Park County HS (MT) | 26 | ? | |
| 1921 | L | Whitehall HS (NY) | 0 | Saratoga Springs HS (NY) | 36 | ? | |
| 1921 | L | Whiting HS (IN) | 0 | Gary Froebel HS (IN) | 48 | ? | |
| 1921 | L | Whitinsville HS (MA) | 6 | Hudson HS (MA) | 24 | ? | |
| 1921 | W | Whitman (WA) | 17 | College of Idaho | 14 | Walla Walla, WA | |
| 1921 | W | Whitman (WA) | 14 | Idaho | 3 | Moscow, ID | |
| 1921 | W | Whitman (WA) | 14 | Montana | 6 | Missoula, MT | |
| 1921 | L | Whitman (WA) | 6 | Multnomah AC (OR) | 18 | Portland, OR | |
| 1921 | L | Whitman (WA) | 0 | Washington | 7 | Seattle, WA | |
| 1921 | W | Whitman (WA) | 25 | Willamette (OR) | 0 | Walla Walla, WA | |
| 1921 | W | Whittier (CA) | 39 | California Tech | 0 | Whittier, CA | |
| 1921 | T | Whittier (CA) | 0 | Loyola Marymount (CA) | 0 | ? | |
| 1921 | W | Whittier (CA) | 16 | Redlands (CA) | 7 | Redlands, CA | |
| 1921 | L | Whittier (CA) | 0 | Southern California | 14 | Los Angeles, CA | |
| 1921 | L | Whittier (CA) | 0 | Arizona | 7 | Tucson, AZ | |
| 1921 | W | Whittier (CA) | 62 | UCLA | 0 | Los Angeles, CA | |
| 1921 | W | Whittier (CA) | 10 | Occidental (CA) | 6 | Whittier, CA | |
| 1921 | W | Whittier (CA) | 42 | Pomona-Pitzer (CA) | 9 | Claremont, CA | |
| 1921 | L | Whittier B Team (CA) | 0 | Sherman Indian School (CA) | 9 | ? | |
| 1921 | L | Whittier HS (CA) | 0 | Santa Ana HS (CA) | 66 | ? | |
| 1921 | L | Whittier HS (CA) | 0 | Santa Monica HS (CA) | 30 | ? | |
| 1921 | L | Whittier HS (CA) | 0 | South Pasadena HS (CA) | 7 | ? | |
| 1921 | L | Whittier Reform School | 7 | Chaffee HS (CA) | 21 | ? | |
| 1921 | L | Whitworth (WA) | 2 | Eastern Washington | 21 | Cheney, WA | |
| 1921 | L | Wichita HS (KS) | 0 | Kingman HS (KS) | 47 | ? | |
| 1921 | L | Wichita HS (KS) | 0 | Tulsa Central HS (OK) | 2 | ? | |
| 1921 | T | Wichita St. (KS) | 0 | Friends (KS) | 0 | Wichita, KS | |
| 1921 | W | Wichita St. (KS) | 24 | Kansas Wesleyan | 0 | Wichita, KS | Kansas Wesleyan left field during game |
| 1921 | W | Wichita St. (KS) | 7 | Sterling (KS) | 0 | Sterling, KS | |
| 1921 | L | Wichita St. (KS) | 6 | Washburn (KS) | 7 | Topeka, KS | |
| 1921 | W | Wichita St. (KS) | 24 | McPherson (KS) | 0 | McPherson, KS | |
| 1921 | L | Wichita St. (KS) | 0 | Southwestern (KS) | 7 | Winfield, KS | |
| 1921 | W | Wichita St. (KS) | 10 | Bethany (KS) | 0 | Wichita, KS | |
| 1921 | W | Wichita St. (KS) | 28 | Oklahoma Baptist University | 3 | Wichita, KS | |
| 1921 | L | Widener (PA) | 0 | Delaware | 6 | Wilmington, DE | |
| 1921 | L | Widener (PA) | 14 | Franklin & Marshall (PA) | 41 | Chester, PA | |
| 1921 | W | Widener (PA) | 12 | Gallaudet (DC) | 0 | Chester, PA | |
| 1921 | W | Widener (PA) | 3 | Saint John's (MD) | 0 | Chester, PA | |
| 1921 | W | Widener (PA) | 26 | Washington (MD) | 7 | Chester, PA | |
| 1921 | L | Widener (PA) | 20 | Albright (PA) | 27 | Huntingdon, PA | |
| 1921 | W | Widener (PA) | 12 | Ursinus (PA) | 0 | Chester, PA | |
| 1921 | L | Widener (PA) | 7 | Villanova (PA) | 19 | Chester, PA | |
| 1921 | T | Widener (PA) | 0 | Connecticut | 0 | Chester, PA | |
| 1921 | L | Wier | 9 | Ackerman HS (MS) | 28 | ? | |
| 1921 | L | Wilberforce (OH) | 0 | Fisk (TN) | 14 | ? | |
| 1921 | W | Wilberforce (OH) | 33 | Kentucky St. | 0 | ? | |
| 1921 | L | Wilberforce (OH) | 6 | Lincoln (PA) | 20 | Lincoln, PA | |
| 1921 | W | Wilberforce (OH) | 20 | Roger Williams (TN) | 0 | ? | |
| 1921 | W | Wilberforce (OH) | 6 | Simmons (KY) | 0 | ? | |
| 1921 | L | Wilberforce (OH) | 0 | West Virginia St. | 14 | Institute, WV | |
| 1921 | L | Wilby HS | 0 | Bridgeport HS (CT) | 66 | ? | |
| 1921 | L | Wilby HS | 0 | Stamford HS (CT) | 80 | ? | |
| 1921 | L | Wilby HS | 0 | Torrington HS (CT) | 33 | ? | |
| 1921 | W | Wildwood HS (NJ) | 6 | Atlantic City HS JV (NJ) | 0 | ? | |
| 1921 | W | Wildwood HS (NJ) | 13 | Cape May C.H. (NJ) | 0 | ? | |
| 1921 | L | Wildwood HS (NJ) | 7 | Cape May C.H. (NJ) | 14 | ? | |
| 1921 | L | Wildwood HS (NJ) | 0 | Ocean City HS (NJ) | 13 | ? | |
| 1921 | L | Wildwood HS (NJ) | 0 | Ocean City HS (NJ) | 6 | ? | |
| 1921 | L | Wildwood HS (NJ) | 0 | Pleasantville HS (NJ) | 21 | ? | |
| 1921 | W | Wiley (TX) | 40 | Jarvis Christian (TX) | 0 | ? | |
| 1921 | W | Wiley (TX) | 14 | Paul Quinn (TX) | 10 | Waco, TX | |
| 1921 | W | Wiley (TX) | 7 | Prairie View A&M (TX) | 3 | ? | |
| 1921 | W | Wiley (TX) | 115 | Shreveport HS (LA) | 0 | ? | |
| 1921 | W | Wiley (TX) | 32 | Southern (LA) | 13 | ? | |
| 1921 | T | Wiley (TX) | 7 | Talladega (AL) | 7 | ? | |
| 1921 | L | Wilkens AA | 0 | Rock Hill College (MD) | 7 | ? | |
| 1921 | T | Wilkes-Barre HS (PA) | 6 | Hanover HS (PA) | 6 | ? | |
| 1921 | L | Wilkes-Barre HS (PA) | 0 | Harrisburg Tech HS (PA) | 91 | ? | |
| 1921 | W | Wilkes-Barre HS (PA) | 13 | Keystone Academy (PA) | 7 | ? | |
| 1921 | T | Wilkes-Barre HS (PA) | 0 | Nanticoke HS (PA) | 0 | ? | |
| 1921 | L | Wilkes-Barre HS (PA) | 0 | Plymouth HS (PA) | 7 | ? | |
| 1921 | L | Wilkes-Barre HS (PA) | 7 | Scranton (PA) | 21 | ? | |
| 1921 | L | Wilkes-Barre HS (PA) | 0 | Scranton Tech HS (PA) | 32 | ? | |
| 1921 | L | Wilkes-Barre HS (PA) | 7 | Williamsport HS (PA) | 13 | ? | |
| 1921 | L | Wilkes-Barre HS (PA) | 6 | Wyoming Seminary B Team (PA) | 13 | ? | |
| 1921 | W | Wilkinsburg HS (PA) | 12 | Avalon HS (PA) | 0 | ? | |
| 1921 | L | Wilkinsburg HS (PA) | 0 | Beaver Falls HS (PA) | 14 | ? | |
| 1921 | W | Wilkinsburg HS (PA) | 14 | Butler HS (PA) | 0 | ? | |
| 1921 | W | Wilkinsburg HS (PA) | 7 | Homestead HS (PA) | 0 | ? | |
| 1921 | W | Wilkinsburg HS (PA) | 13 | Latrobe HS (PA) | 6 | ? | |
| 1921 | W | Wilkinsburg HS (PA) | 14 | Norwin HS | 0 | ? | |
| 1921 | W | Wilkinsburg HS (PA) | 6 | Pittsburgh Peabody HS (PA) | 0 | ? | |
| 1921 | W | Wilkinsburg HS (PA) | 7 | Shady Side Academy (PA) | 0 | ? | |
| 1921 | T | Wilkinsburg HS (PA) | 0 | Union HS (PA) | 0 | ? | |
| 1921 | L | Will Mayfield College (MO) | 0 | Marvin College (MO) | 6 | ? | |
| 1921 | W | Willamette (OR) | 14 | Chemawa Indian School (OR) | 7 | Salem, OR | |
| 1921 | L | Willamette (OR) | 0 | Oregon St. | 54 | Salem, OR | |
| 1921 | L | Willamette (OR) | 10 | Pacific (OR) | 27 | ? | |
| 1921 | L | Willamette (OR) | 7 | Puget Sound (WA) | 18 | Tacoma, WA | |
| 1921 | L | Willamette (OR) | 3 | Oregon | 7 | Salem, OR | |
| 1921 | L | Willamette (OR) | 0 | Whitman (WA) | 25 | Walla Walla, WA | |
| 1921 | T | William & Mary (VA) | 7 | George Washington (DC) | 7 | Norfolk, VA | |
| 1921 | W | William & Mary (VA) | 35 | Randolph-Macon (VA) | 0 | Williamsburg, VA | |
| 1921 | L | William & Mary (VA) | 7 | Richmond (VA) | 17 | Richmond, VA | |
| 1921 | W | William & Mary (VA) | 21 | Wake Forest (NC) | 14 | Williamsburg, VA | |
| 1921 | L | William & Mary (VA) | 0 | Virginia Tech | 14 | Blacksburg, VA | |
| 1921 | L | William & Mary (VA) | 13 | Catholic (DC) | 27 | Newport News, VA | |
| 1921 | W | William & Mary (VA) | 12 | Duke (NC) | 0 | Durham, NC | |
| 1921 | W | William & Mary (VA) | 76 | Union Theological Seminary (VA) | 0 | Williamsburg, VA | |
| 1921 | W | William & Mary JV (VA) | 23 | Newport News Apprentice School (VA) | 0 | ? | |
| 1921 | L | William Jewell (MO) | 0 | Baker (KS) | 7 | ? | |
| 1921 | L | William Jewell (MO) | 0 | Central Methodist (MO) | 7 | ? | |
| 1921 | W | William Jewell (MO) | 17 | Drury (MO) | 0 | Liberty, MO | |
| 1921 | W | William Jewell (MO) | 10 | Missouri St. | 0 | Springfield, MO | |
| 1921 | W | William Jewell (MO) | 3 | Missouri Wesleyan | 0 | Cameron, MO | |
| 1921 | W | William Jewell (MO) | 7 | Westminster (MO) | 0 | ? | |
| 1921 | W | William Jewell (MO) | 19 | Central Missouri St. | 0 | Liberty, MO | |
| 1921 | W | William Jewell (MO) | 41 | Tarkio (MO) | 7 | Saint Joseph, MO | |
| 1921 | L | William Penn (IA) | 0 | Central (IA) | 8 | ? | |
| 1921 | L | William Penn (IA) | 0 | Dubuque (IA) | 28 | Dubuque, IA | |
| 1921 | W | William Penn (IA) | 3 | Parsons (IA) | 0 | Fairfield, IA | |
| 1921 | L | William Penn (IA) | 0 | Simpson (IA) | 7 | Oskaloosa, IA | |
| 1921 | L | William Penn (IA) | 7 | Des Moines (IA) | 27 | Des Moines, IA | |
| 1921 | L | William Penn (IA) | 0 | Drake (IA) | 42 | Oskaloosa, IA | |
| 1921 | L | William Penn (IA) | 6 | Northern Iowa | 14 | Oskaloosa, IA | |
| 1921 | L | William Warren Military School (CA) | 7 | Hollister HS (CA) | 21 | ? | |
| 1921 | W | William Warren Military School (CA) | 14 | Menlo Park HS (CA) | 0 | ? | |
| 1921 | L | William Warren Military School (CA) | 0 | Mountain View HS (CA) | 27 | ? | |
| 1921 | L | William Warren Military School (CA) | 0 | Palo Alto HS (CA) | 30 | ? | |
| 1921 | L | William Warren Military School (CA) | 7 | Potter School (CA) | 35 | ? | |
| 1921 | W | William Warren Military School (CA) | 60 | Presidio of San Francisco (CA) | 0 | ? | |
| 1921 | W | William Warren Military School (CA) | 21 | Redwood HS (CA) | 7 | ? | |
| 1921 | L | William Warren Military School (CA) | 0 | San Jose HS (CA) | 14 | ? | |
| 1921 | T | William Warren Military School (CA) | 7 | San Rafael HS (CA) | 7 | ? | |
| 1921 | L | William Warren Military School (CA) | 16 | Santa Clara University HS (CA) | 19 | ? | |
| 1921 | W | William Warren Military School (CA) | 7 | Stanford 145-lb | 6 | ? | |
| 1921 | L | William Warren Military School (CA) | 7 | Tamalpais HS (CA) | 27 | ? | |
| 1921 | W | Williams (MA) | 20 | Columbia (NY) | 0 | Williamstown, MA | |
| 1921 | L | Williams (MA) | 3 | Middlebury (VT) | 7 | Williamstown, MA | |
| 1921 | W | Williams (MA) | 40 | Wesleyan (CT) | 0 | Middletown, CT | |
| 1921 | L | Williams (MA) | 0 | Yale (CT) | 23 | New Haven, CT | |
| 1921 | W | Williams (MA) | 14 | Hamilton (NY) | 0 | Clinton, NY | |
| 1921 | W | Williams (MA) | 44 | Union (NY) | 0 | Williamstown, MA | |
| 1921 | T | Williams (MA) | 0 | Bowdoin (ME) | 0 | Williamstown, MA | |
| 1921 | W | Williams (MA) | 20 | Amherst (MA) | 0 | Williamstown, MA | |
| 1921 | L | Williamson Trade School (PA) | 0 | Hill School (PA) | 34 | ? | |
| 1921 | L | Williamson Trade School (PA) | 0 | Navy Freshmen (MD) | 40 | ? | |
| 1921 | T | Williamson Trade School (PA) | 7 | Pennington Seminary (NJ) | 7 | ? | |
| 1921 | W | Williamson Trade School (PA) | 13 | Philadelphia Northeast HS (PA) | 7 | ? | |
| 1921 | W | Williamson Trade School (PA) | 45 | Stevens Trade School (PA) | 0 | ? | |
| 1921 | T | Williamson Trade School (PA) | 0 | Villanova Prep School (PA) | 0 | ? | |
| 1921 | L | Williamson Trade School (PA) | 14 | West Chester (PA) | 20 | West Chester, PA | |
| 1921 | W | Williamson Trade School (PA) | 14 | Williamson Trade School Alumni (PA) | 7 | ? | |
| 1921 | L | Williamson Trade School Alumni (PA) | 7 | Williamson Trade School (PA) | 14 | ? | |
| 1921 | L | Williamson Trade School JV (PA) | 0 | Coatesville HS (PA) | 7 | ? | |
| 1921 | L | Williamson Trade School JV (PA) | 0 | Pennsylvania Institution for the Deaf | 98 | ? | |
| 1921 | W | Williamsport HS (PA) | 39 | Altoona HS (PA) | 6 | ? | |
| 1921 | W | Williamsport HS (PA) | 23 | Clearfield HS (PA) | 0 | ? | |
| 1921 | W | Williamsport HS (PA) | 25 | Jersey Shore HS (PA) | 12 | ? | |
| 1921 | W | Williamsport HS (PA) | 6 | Lebanon HS (PA) | 2 | ? | |
| 1921 | T | Williamsport HS (PA) | 0 | Lock Haven HS (PA) | 0 | ? | |
| 1921 | W | Williamsport HS (PA) | 51 | Plymouth HS (PA) | 0 | ? | |
| 1921 | W | Williamsport HS (PA) | 56 | Shamokin HS (PA) | 0 | ? | |
| 1921 | L | Williamsport HS (PA) | 0 | Steelton HS (PA) | 26 | ? | |
| 1921 | W | Williamsport HS (PA) | 13 | Sunbury HS (PA) | 0 | ? | |
| 1921 | W | Williamsport HS (PA) | 13 | Wilkes-Barre HS (PA) | 7 | ? | |
| 1921 | W | Williamstown HS (NY) | 19 | Hoosac School (NY) | 6 | ? | |
| 1921 | W | Williamstown HS (NY) | 26 | Hoosac School (NY) | 0 | ? | |
| 1921 | L | Williston Seminary (MA) | 0 | Cushing Academy (MA) | 7 | ? | |
| 1921 | W | Williston Seminary (MA) | 7 | Hopkins Grammar School (CT) | 0 | ? | |
| 1921 | L | Williston Seminary (MA) | 0 | Worcester Academy (MA) | 34 | ? | |
| 1921 | L | Willman HS (MN) | 6 | Montevideo HS (MN) | 7 | ? | |
| 1921 | W | Willmar HS (MN) | 79 | Glencoe HS (MN) | 0 | ? | |
| 1921 | W | Willmar HS (MN) | 26 | Hancock HS (MN) | 0 | ? | |
| 1921 | W | Willmar HS (MN) | 16 | Hector HS (MN) | 13 | ? | |
| 1921 | W | Willmar HS (MN) | 64 | Litchfield HS (MN) | 7 | ? | |
| 1921 | L | Willmar HS (MN) | 6 | Montevideo HS (MN) | 7 | ? | |
| 1921 | W | Willmar HS (MN) | 7 | Saint Cloud HS (MN) | 6 | ? | |
| 1921 | W | Willows HS (CA) | 21 | Cal St.-Chico | 0 | ? | |
| 1921 | L | Willows HS (CA) | 0 | Sacramento HS (CA) | 20 | ? | |
| 1921 | L | Wills-Taylor School | 9 | Baylor Military Academy (TN) | 13 | ? | |
| 1921 | W | Wilmington (OH) | 77 | Cedarville (OH) | 7 | ? | |
| 1921 | W | Wilmington (OH) | 30 | Dayton (OH) | 0 | ? | |
| 1921 | W | Wilmington (OH) | 20 | Franklin (IN) | 7 | Franklin, IN | |
| 1921 | W | Wilmington (OH) | 32 | Muskingum (OH) | 0 | New Concord, OH | |
| 1921 | W | Wilmington (OH) | 14 | Otterbein (OH) | 13 | ? | |
| 1921 | W | Wilmington (OH) | 49 | Antioch (OH) | 0 | Yellow Springs, OH | |
| 1921 | W | Wilmington (OH) | 6 | Earlham (IN) | 0 | Richmond, IN | |
| 1921 | W | Wilmington (OH) | 14 | Defiance (OH) | 0 | Wilmington, OH | |
| 1921 | T | Wilmington HS (DE) | 0 | Bristol HS (PA) | 0 | ? | |
| 1921 | L | Wilmington HS (DE) | 6 | Chester HS (PA) | 13 | ? | |
| 1921 | L | Wilmington HS (DE) | 0 | Pennsylvania Institution for the Deaf | 28 | ? | |
| 1921 | W | Wilmington HS (DE) | 13 | Tome Institute (MD) | 0 | ? | |
| 1921 | L | Wilmington HS (DE) | 7 | Villanova Prep School (PA) | 10 | ? | |
| 1921 | W | Wilmington HS (DE) | 7 | West Chester HS (PA) | 6 | ? | |
| 1921 | W | Wilmington HS (OH) | 63 | Blanchester HS (OH) | 7 | ? | |
| 1921 | L | Wilmington HS (OH) | 2 | Chillicothe HS (OH) | 6 | ? | |
| 1921 | W | Wilmington HS (OH) | 6 | Circleville HS (OH) | 0 | ? | |
| 1921 | W | Wilmington HS (OH) | 28 | Greenfield HS (OH) | 0 | ? | |
| 1921 | W | Wilmington HS (OH) | 20 | Newark HS (DE) | 0 | ? | |
| 1921 | T | Wilmington HS (OH) | 0 | Washington Court House HS (OH) | 0 | ? | |
| 1921 | W | Wilmington HS (OH) | 41 | Washington Court House HS (OH) | 0 | ? | |
| 1921 | L | Wilmington HS (OH) | 0 | Xenia Central HS (OH) | 19 | ? | |
| 1921 | L | Wilmington HS (OH) | 0 | Xenia Central HS (OH) | 26 | ? | |
| 1921 | W | Wilmington Light Infantry (NC) | 34 | Atlantic Christian (NC) | 0 | ? | |
| 1921 | L | Wilson HS (AR) | 0 | Memphis (TN) | 14 | Wilson, AR | |
| 1921 | L | Wilson HS (NC) | 7 | Rocky Mount HS (NC) | 48 | ? | |
| 1921 | L | Wilson HS (NC) | 7 | Rocky Mount HS (NC) | 54 | ? | |
| 1921 | L | Wilson HS (NC) | 0 | Smithfield HS (NC) | 7 | ? | |
| 1921 | L | Wilson HS (PA) | 0 | Allentown HS (PA) | 75 | ? | |
| 1921 | L | Wilson HS (PA) | 0 | Bethlehem HS (PA) | 63 | ? | |
| 1921 | L | Wilson HS (PA) | 0 | Easton HS (PA) | 68 | ? | |
| 1921 | W | Wilson HS (PA) | 14 | Hackettstown HS (NJ) | 0 | ? | |
| 1921 | L | Wilson HS (PA) | 6 | Quakertown HS (PA) | 7 | ? | |
| 1921 | L | Winchester HS (KY) | 14 | Louisville HS (KY) | 21 | ? | |
| 1921 | W | Winchester HS (KY) | 16 | Morganfield HS (KY) | 0 | ? | |
| 1921 | T | Winchester HS (MA) | 0 | Melrose HS (MA) | 0 | ? | |
| 1921 | W | Winchester HS (MA) | 7 | Wakefield HS (MA) | 0 | ? | |
| 1921 | L | Winchester HS (MA) | 0 | Woburn HS (MA) | 41 | ? | |
| 1921 | L | Winchester HS (VA) | 0 | Shenandoah Military Academy (VA) | 7 | ? | |
| 1921 | L | Windber HS (PA) | 0 | Altoona HS (PA) | 1 | ? | |
| 1921 | L | Windber HS (PA) | 6 | Clearfield HS (PA) | 12 | ? | |
| 1921 | L | Windber HS (PA) | 0 | Johnstown HS (PA) | 27 | ? | |
| 1921 | L | Windham HS (CT) | 0 | New London Vocational HS (CT) | 20 | ? | |
| 1921 | W | Windsor | 7 | Detroit Northeastern HS (MI) | 0 | ? | |
| 1921 | L | Windsor HS (CO) | 0 | Boulder Prep School (CO) | 14 | ? | |
| 1921 | L | Windsor HS (CO) | 7 | Greeley HS (CO) | 26 | ? | |
| 1921 | L | Winner HS (SD) | 0 | Dallas HS (SD) | 45 | ? | |
| 1921 | L | Winner HS (SD) | 0 | Dallas HS (SD) | 34 | ? | |
| 1921 | L | Winnett HS (MT) | 13 | Harlowton HS (MT) | 26 | ? | |
| 1921 | L | Winnett HS (MT) | 7 | Harlowton HS (MT) | 35 | ? | |
| 1921 | W | Winona HS (MN) | 23 | Austin HS (MN) | 0 | ? | |
| 1921 | L | Winona HS (MN) | 0 | Dunwoody College of Tech. (MN) | 54 | ? | |
| 1921 | L | Winona HS (MN) | 3 | Red Wing HS (MN) | 13 | ? | |
| 1921 | L | Winona HS (MN) | 7 | Stillwater HS (MN) | 34 | ? | |
| 1921 | L | Winona HS (MS) | 13 | Grenada HS (MS) | 19 | ? | |
| 1921 | W | Winona St. (MN) | 27 | Cotter HS | 0 | ? | |
| 1921 | W | Winona St. (MN) | 49 | La Crosse HS (WI) | 0 | ? | |
| 1921 | T | Winona St. (MN) | 14 | Rochester C&T College (MN) | 14 | ? | |
| 1921 | L | Winona St. (MN) | 0 | Saint Cloud St. (MN) | 7 | ? | |
| 1921 | L | Winona St. (MN) | 0 | Shattuck School (MN) | 16 | ? | |
| 1921 | T | Winona St. (MN) | 6 | Wisconsin-La Crosse JV | 6 | ? | |
| 1921 | L | Winona St. (MN) | 0 | Wisconsin-Stout | 31 | Menomonie, WI | |
| 1921 | W | Winslow HS (AZ) | 18 | Northern Arizona | 0 | Flagstaff, AZ | |
| 1921 | L | Winthrop HS (MA) | 0 | Brookline HS (MA) | 7 | ? | |
| 1921 | L | Winthrop HS (MA) | 0 | Gloucester HS (MA) | 7 | ? | |
| 1921 | L | Winthrop HS (MA) | 6 | Marblehead HS (MA) | 27 | ? | |
| 1921 | L | Winthrop HS (MA) | 0 | Peabody HS (MA) | 34 | ? | |
| 1921 | L | Winthrop HS (MA) | 0 | Revere HS (MA) | 13 | ? | |
| 1921 | L | Wisconsin | 0 | Chicago (IL) | 3 | Chicago, IL | |
| 1921 | W | Wisconsin | 20 | Illinois | 0 | Champaign, IL | |
| 1921 | W | Wisconsin | 35 | Minnesota | 0 | Madison, WI | |
| 1921 | W | Wisconsin | 27 | Northwestern (IL) | 0 | Evanston, IL | |
| 1921 | W | Wisconsin | 28 | Lawrence (WI) | 0 | Madison, WI | |
| 1921 | W | Wisconsin | 24 | South Dakota St. | 3 | Madison, WI | |
| 1921 | T | Wisconsin | 7 | Michigan | 7 | Madison, WI | |
| 1921 | W | Wisconsin Medical College | 20 | Wisconsin Tech | 6 | ? | |
| 1921 | L | Wisconsin Tech | 6 | Milwaukee School of Engineering (WI) | 14 | Milwaukee, WI | |
| 1921 | L | Wisconsin Tech | 0 | Saint John's Military Academy (WI) | 28 | ? | |
| 1921 | L | Wisconsin Tech | 0 | Wisconsin-Platteville | 7 | ? | |
| 1921 | L | Wisconsin Tech | 0 | Campion College (WI) | 13 | ? | |
| 1921 | L | Wisconsin Tech | 6 | Loras (IA) | 20 | Dubuque, IA | |
| 1921 | L | Wisconsin Tech | 6 | Wisconsin Medical College | 20 | ? | |
| 1921 | W | Wisconsin-Eau Claire | 20 | Saint Mary's (MN) | 0 | Winona, MN | |
| 1921 | L | Wisconsin-Eau Claire | 3 | Wisconsin-Superior | 7 | Superior, WI | |
| 1921 | L | Wisconsin-Eau Claire | 0 | Wisconsin-Stout | 27 | Eau Claire, WI | |
| 1921 | W | Wisconsin-Eau Claire | 21 | Wisconsin-River Falls | 13 | Eau Claire, WI | |
| 1921 | T | Wisconsin-Eau Claire | 6 | Wisconsin-Stevens Point | 6 | Eau Claire, WI | |
| 1921 | T | Wisconsin-La Crosse | 0 | Wisconsin-Milwaukee | 0 | La Crosse, WI | |
| 1921 | W | Wisconsin-La Crosse | 0 | Wisconsin-Platteville | 13 | Platteville, WI | Wisconsin-Platteville Forfeits |
| 1921 | L | Wisconsin-La Crosse | 0 | Wisconsin-River Falls | 3 | La Crosse, WI | |
| 1921 | W | Wisconsin-La Crosse | 6 | Wisconsin-Whitewater | 3 | Whitewater, WI | |
| 1921 | L | Wisconsin-La Crosse | 13 | Saint Thomas (MN) | 28 | La Crosse, WI | |
| 1921 | W | Wisconsin-La Crosse | 7 | Wisconsin-Oshkosh | 6 | La Crosse, WI | |
| 1921 | T | Wisconsin-La Crosse JV | 6 | Winona St. (MN) | 6 | ? | |
| 1921 | W | Wisconsin-Milwaukee | 14 | Carroll (WI) | 0 | Waukesha, WI | |
| 1921 | W | Wisconsin-Milwaukee | 44 | Milton (WI) | 0 | Milwaukee, WI | |
| 1921 | W | Wisconsin-Milwaukee | 13 | Northwestern (WI) | 0 | ? | |
| 1921 | T | Wisconsin-Milwaukee | 0 | Wisconsin-La Crosse | 0 | La Crosse, WI | |
| 1921 | L | Wisconsin-Milwaukee | 0 | Wisconsin-Stevens Point | 12 | Milwaukee, WI | |
| 1921 | L | Wisconsin-Milwaukee | 0 | Wisconsin-Whitewater | 7 | Milwaukee, WI | |
| 1921 | W | Wisconsin-Milwaukee | 26 | Northern Illinois | 0 | DeKalb, IL | |
| 1921 | W | Wisconsin-Oshkosh | 3 | Lawrence (WI) | 0 | Appleton, WI | |
| 1921 | W | Wisconsin-Oshkosh | 27 | Wisconsin-Platteville | 7 | Oshkosh, WI | |
| 1921 | W | Wisconsin-Oshkosh | 14 | Wisconsin-River Falls | 2 | Oshkosh, WI | |
| 1921 | W | Wisconsin-Oshkosh | 22 | Wisconsin-Whitewater | 7 | Oshkosh, WI | |
| 1921 | L | Wisconsin-Oshkosh | 6 | Ripon (WI) | 21 | Ripon, WI | |
| 1921 | W | Wisconsin-Oshkosh | 28 | Saint John's Military Academy (WI) | 0 | Oshkosh, WI | |
| 1921 | L | Wisconsin-Oshkosh | 6 | Wisconsin-La Crosse | 7 | La Crosse, WI | |
| 1921 | W | Wisconsin-Platteville | 16 | Campion College (WI) | 6 | Prairie du Chien, WI | |
| 1921 | W | Wisconsin-Platteville | 9 | Saint Ambrose (IA) | 7 | Davenport, IA | |
| 1921 | W | Wisconsin-Platteville | 7 | Wisconsin Tech | 0 | ? | |
| 1921 | L | Wisconsin-Platteville | 13 | Wisconsin-La Crosse | 0 | Platteville, WI | Wisconsin-Platteville Forfeits |
| 1921 | L | Wisconsin-Platteville | 7 | Wisconsin-Oshkosh | 27 | Oshkosh, WI | |
| 1921 | W | Wisconsin-Platteville | 7 | Loras (IA) | 6 | Platteville, WI | |
| 1921 | L | Wisconsin-Platteville | 7 | Wisconsin-Whitewater | 35 | Platteville, WI | |
| 1921 | W | Wisconsin-River Falls | 21 | Saint Mary's (MN) | 0 | River Falls, WI | |
| 1921 | W | Wisconsin-River Falls | 7 | Shattuck School (MN) | 0 | ? | |
| 1921 | W | Wisconsin-River Falls | 3 | Wisconsin-La Crosse | 0 | La Crosse, WI | |
| 1921 | L | Wisconsin-River Falls | 2 | Wisconsin-Oshkosh | 14 | Oshkosh, WI | |
| 1921 | L | Wisconsin-River Falls | 7 | Wisconsin-Stout | 14 | River Falls, WI | |
| 1921 | L | Wisconsin-River Falls | 13 | Wisconsin-Eau Claire | 21 | Eau Claire, WI | |
| 1921 | L | Wisconsin-River Falls | 0 | Carleton (MN) | 63 | Northfield, MN | |
| 1921 | T | Wisconsin-River Falls | 7 | Wisconsin-Superior | 7 | River Falls, WI | |
| 1921 | W | Wisconsin-Stevens Point | 9 | Milwaukee School of Engineering (WI) | 7 | Stevens Point, WI | |
| 1921 | W | Wisconsin-Stevens Point | 108 | Saint Norbert (WI) | 0 | Stevens Point, WI | |
| 1921 | W | Wisconsin-Stevens Point | 12 | Wisconsin-Milwaukee | 0 | Milwaukee, WI | |
| 1921 | L | Wisconsin-Stevens Point | 6 | Wisconsin-Superior | 7 | Superior, WI | |
| 1921 | L | Wisconsin-Stevens Point | 0 | Lawrence (WI) | 22 | Appleton, WI | |
| 1921 | T | Wisconsin-Stevens Point | 6 | Wisconsin-Eau Claire | 6 | Eau Claire, WI | |
| 1921 | W | Wisconsin-Stout | 37 | Dunwoody College of Tech. (MN) | 0 | Menomonie, WI | |
| 1921 | T | Wisconsin-Stout | 0 | Macalester (MN) | 0 | Saint Paul, MN | |
| 1921 | W | Wisconsin-Stout | 31 | Winona St. (MN) | 0 | Menomonie, WI | |
| 1921 | W | Wisconsin-Stout | 14 | Wisconsin-River Falls | 7 | River Falls, WI | |
| 1921 | W | Wisconsin-Stout | 27 | Wisconsin-Eau Claire | 0 | Eau Claire, WI | |
| 1921 | W | Wisconsin-Stout | 13 | Wisconsin-Superior | 12 | Menomonie, WI | |
| 1921 | T | Wisconsin-Stout | 7 | Saint Mary's (MN) | 7 | Winona, MN | |
| 1921 | W | Wisconsin-Superior | 1 | North Dakota | 0 | ? | North Dakota Forfeits |
| 1921 | W | Wisconsin-Superior | 62 | Saint Cloud St. (MN) | 0 | ? | |
| 1921 | W | Wisconsin-Superior | 7 | Wisconsin-Eau Claire | 3 | Superior, WI | |
| 1921 | W | Wisconsin-Superior | 7 | Wisconsin-Stevens Point | 6 | Superior, WI | |
| 1921 | W | Wisconsin-Superior | 57 | Eveleth JC (MN) | 7 | ? | |
| 1921 | L | Wisconsin-Superior | 12 | Wisconsin-Stout | 13 | Menomonie, WI | |
| 1921 | T | Wisconsin-Superior | 7 | Wisconsin-River Falls | 7 | River Falls, WI | |
| 1921 | T | Wisconsin-Whitewater | 0 | Marquette Academy (WI) | 0 | ? | |
| 1921 | W | Wisconsin-Whitewater | 34 | Milton (WI) | 0 | Whitewater, WI | |
| 1921 | L | Wisconsin-Whitewater | 3 | Wisconsin-La Crosse | 6 | Whitewater, WI | |
| 1921 | L | Wisconsin-Whitewater | 7 | Wisconsin-Oshkosh | 22 | Oshkosh, WI | |
| 1921 | W | Wisconsin-Whitewater | 7 | Wisconsin-Milwaukee | 0 | Milwaukee, WI | |
| 1921 | W | Wisconsin-Whitewater | 35 | Wisconsin-Platteville | 7 | Platteville, WI | |
| 1921 | W | Wittenberg (OH) | 7 | Cincinnati (OH) | 2 | Cincinnati, OH | |
| 1921 | W | Wittenberg (OH) | 28 | Muskingum (OH) | 6 | Springfield, OH | |
| 1921 | L | Wittenberg (OH) | 0 | Ohio Northern | 7 | Ada, OH | |
| 1921 | T | Wittenberg (OH) | 0 | Ohio Wesleyan | 0 | Springfield, OH | |
| 1921 | W | Wittenberg (OH) | 7 | Western Reserve (OH) | 0 | Cleveland, OH | |
| 1921 | L | Wittenberg (OH) | 0 | Oberlin (OH) | 16 | Oberlin, OH | |
| 1921 | T | Wittenberg (OH) | 0 | Kenyon (OH) | 0 | Springfield, OH | |
| 1921 | L | Wittenberg (OH) | 0 | Miami (OH) | 14 | Oxford, OH | |
| 1921 | W | Wittenberg (OH) | 20 | Otterbein (OH) | 0 | Springfield, OH | |
| 1921 | W | Woburn HS (MA) | 14 | Arlington HS (MA) | 7 | ? | |
| 1921 | W | Woburn HS (MA) | 7 | Lexington HS (MA) | 0 | ? | |
| 1921 | W | Woburn HS (MA) | 12 | Lowell HS (MA) | 6 | ? | |
| 1921 | L | Woburn HS (MA) | 6 | Malden HS (MA) | 32 | ? | |
| 1921 | W | Woburn HS (MA) | 14 | Melrose HS (MA) | 0 | ? | |
| 1921 | W | Woburn HS (MA) | 14 | Nashua HS | 0 | ? | |
| 1921 | W | Woburn HS (MA) | 7 | Salem HS (MA) | 0 | ? | |
| 1921 | W | Woburn HS (MA) | 14 | Wakefield HS (MA) | 7 | ? | |
| 1921 | W | Woburn HS (MA) | 33 | Watertown HS (MA) | 0 | ? | |
| 1921 | W | Woburn HS (MA) | 41 | Winchester HS (MA) | 0 | ? | |
| 1921 | L | Wofford (SC) | 0 | Davidson (NC) | 87 | Davidson, NC | |
| 1921 | L | Wofford (SC) | 0 | Duke (NC) | 68 | Spartanburg, SC | |
| 1921 | W | Wofford (SC) | 20 | Elon (NC) | 7 | Spartanburg, SC | |
| 1921 | L | Wofford (SC) | 0 | Furman (SC) | 62 | Greenville, SC | |
| 1921 | L | Wofford (SC) | 21 | Newberry (SC) | 33 | Spartanburg, SC | |
| 1921 | W | Wofford (SC) | 22 | North Georgia | 0 | Spartanburg, SC | |
| 1921 | L | Wofford (SC) | 6 | Erskine (SC) | 19 | Spartanburg, SC | |
| 1921 | L | Wofford (SC) | 0 | Citadel (SC) | 28 | Charleston, SC | |
| 1921 | L | Wofford (SC) | 0 | Presbyterian (SC) | 27 | Clinton, SC | |
| 1921 | L | Wofford Fitting School (SC) | 0 | Porter Military Academy (SC) | 33 | ? | |
| 1921 | L | Wolf Point HS (MT) | 0 | Williston HS (ND) | 101 | ? | |
| 1921 | W | Wolverines | 13 | Alexandria Episcopal HS (VA) | 7 | ? | |
| 1921 | W | Wolverines | 20 | Asheville School (NC) | 13 | ? | |
| 1921 | T | Wolverines | 0 | Augusta Military Academy (VA) | 0 | ? | |
| 1921 | T | Wolverines | 0 | Fishburne Military School (VA) | 0 | ? | |
| 1921 | L | Wolverines | 0 | North Carolina Freshmen | 21 | ? | |
| 1921 | W | Wolverines | 7 | Virginia Episcopal School (VA) | 6 | ? | |
| 1921 | L | Wolverines | 7 | Virginia Freshmen | 13 | ? | |
| 1921 | L | Woodbury HS (NJ) | 7 | Abington HS (PA) | 26 | ? | |
| 1921 | W | Woodbury HS (NJ) | 14 | Atlantic City HS (NJ) | 6 | ? | |
| 1921 | T | Woodbury HS (NJ) | 7 | Collingswood HS (NJ) | 7 | ? | |
| 1921 | W | Woodbury HS (NJ) | 10 | Glassboro HS (NJ) | 0 | ? | |
| 1921 | W | Woodbury HS (NJ) | 21 | Haddon Heights HS (NJ) | 7 | ? | |
| 1921 | L | Woodbury HS (NJ) | 0 | La Salle Prep School (PA) | 3 | ? | |
| 1921 | W | Woodbury HS (NJ) | 7 | Millville HS (NJ) | 0 | ? | |
| 1921 | W | Woodbury HS (NJ) | 27 | Vineland HS (NJ) | 7 | ? | |
| 1921 | T | Woodbury HS (NJ) | 13 | Wenonah Military Academy (NJ) | 13 | ? | |
| 1921 | L | Woodbury HS (PA) | 7 | Abington HS (PA) | 26 | ? | |
| 1921 | L | Woodlake HS (CA) | 0 | Dinuba HS (CA) | 40 | ? | |
| 1921 | L | Woodland HS (CA) | 7 | Glenn County HS (CA) | 32 | ? | |
| 1921 | L | Woodland HS (CA) | 7 | Sacramento HS (CA) | 55 | ? | |
| 1921 | L | Woodland HS (CA) | 0 | Sacramento HS (CA) | 68 | ? | |
| 1921 | L | Woodlawn HS | 7 | Monaca HS (PA) | 27 | ? | |
| 1921 | L | Woodlawn HS | 7 | Rochester HS (PA) | 34 | ? | |
| 1921 | L | Woodsfield HS (OH) | 7 | Sistersville HS (WV) | 45 | ? | |
| 1921 | L | Woodstock HS (IL) | 0 | Chicago Carl Schurz HS (IL) | 7 | ? | |
| 1921 | L | Woodstock HS (OH) | 0 | London HS (OH) | 27 | ? | |
| 1921 | W | Woodstock HS (OH) | 18 | Richmond HS (OH) | 6 | ? | |
| 1921 | L | Woodstown HS (NJ) | 0 | Glassboro HS (NJ) | 13 | ? | |
| 1921 | W | Woodstown HS (NJ) | 13 | Gloucester HS (NJ) | 0 | ? | |
| 1921 | T | Woodstown HS (NJ) | 0 | Haddon Heights HS (NJ) | 0 | ? | |
| 1921 | W | Woodstown HS (NJ) | 6 | Haddonfield HS (NJ) | 0 | ? | |
| 1921 | L | Woodstown HS (NJ) | 0 | Hammonton HS (NJ) | 40 | ? | |
| 1921 | L | Woodstown HS (NJ) | 0 | Millville HS (NJ) | 13 | ? | |
| 1921 | L | Woodstown HS (NJ) | 7 | Penns Grove HS (NJ) | 45 | ? | |
| 1921 | W | Wooster (OH) | 17 | Case Institute of Technology (OH) | 3 | Wooster, OH | |
| 1921 | L | Wooster (OH) | 0 | Kenyon (OH) | 3 | Gambier, OH | |
| 1921 | W | Wooster (OH) | 6 | Mount Union (OH) | 0 | Alliance, OH | |
| 1921 | W | Wooster (OH) | 7 | Western Reserve (OH) | 0 | Cleveland, OH | |
| 1921 | W | Wooster (OH) | 14 | Hiram (OH) | 0 | Wooster, OH | |
| 1921 | L | Wooster (OH) | 6 | Oberlin (OH) | 14 | Oberlin, OH | |
| 1921 | W | Wooster (OH) | 31 | Denison (OH) | 0 | Wooster, OH | |
| 1921 | W | Wooster (OH) | 13 | Akron (OH) | 0 | Wooster, OH | |
| 1921 | L | Wooster HS (OH) | 0 | Alliance HS (OH) | 26 | ? | |
| 1921 | L | Wooster HS (OH) | 0 | Toledo Scott HS (OH) | 74 | ? | |
| 1921 | W | Worcester Academy (MA) | 27 | Cushing Academy (MA) | 0 | ? | |
| 1921 | L | Worcester Academy (MA) | 0 | Harvard Freshmen (MA) | 7 | ? | |
| 1921 | W | Worcester Academy (MA) | 42 | Huntington HS (MA) | 7 | ? | |
| 1921 | L | Worcester Academy (MA) | 13 | Phillips Andover Academy (MA) | 28 | ? | |
| 1921 | L | Worcester Academy (MA) | 0 | Phillips Exeter Academy (NH) | 13 | ? | |
| 1921 | W | Worcester Academy (MA) | 34 | Williston Seminary (MA) | 0 | ? | |
| 1921 | T | Worcester Classical HS (MA) | 7 | Clinton HS (MA) | 7 | ? | |
| 1921 | L | Worcester Classical HS (MA) | 0 | Haverhill Saint James HS (MA) | 42 | ? | |
| 1921 | T | Worcester Commerce HS (MA) | 6 | Clinton HS (MA) | 6 | ? | |
| 1921 | W | Worcester Commerce HS (MA) | 9 | Everett HS (MA) | 7 | ? | |
| 1921 | L | Worcester Commerce HS (MA) | 0 | Framingham HS (MA) | 27 | ? | |
| 1921 | L | Worcester Commerce HS (MA) | 6 | Haverhill Saint James HS (MA) | 7 | ? | |
| 1921 | L | Worcester Commerce HS (MA) | 0 | Pomfret School (CT) | 3 | ? | |
| 1921 | L | Worcester North HS (MA) | 7 | Fitchburg HS (MA) | 43 | ? | |
| 1921 | L | Worcester North HS (MA) | 0 | Moses Brown School (RI) | 14 | ? | |
| 1921 | W | Worcester South HS (MA) | 13 | Clinton HS (MA) | 8 | ? | |
| 1921 | L | Worcester South HS (MA) | 7 | Fitchburg HS (MA) | 28 | ? | |
| 1921 | L | Worcester South HS (MA) | 0 | Manchester HS (NH) | 26 | ? | |
| 1921 | L | Worcester Tech (MA) | 14 | Connecticut | 27 | Storrs, CT | |
| 1921 | L | Worcester Tech (MA) | 0 | Massachusetts | 35 | Worcester, MA | |
| 1921 | L | Worcester Tech (MA) | 0 | Rhode Island | 27 | Worcester, MA | |
| 1921 | L | Worcester Tech (MA) | 0 | Trinity (CT) | 6 | Hartford, CT | |
| 1921 | L | Worcester Tech (MA) | 0 | Massachusetts-Lowell | 3 | Lowell, MA | |
| 1921 | L | Worcester Tech (MA) | 0 | Boston (MA) | 52 | Boston, MA | |
| 1921 | L | Worcester Tech (MA) | 6 | Rensselaer Tech (NY) | 7 | Worcester, MA | |
| 1921 | L | Worcester Trade (MA) | 0 | Framingham HS (MA) | 35 | ? | |
| 1921 | L | Worcester Trade (MA) | 0 | Natick HS (MA) | 2 | ? | |
| 1921 | L | Worcester Trade (MA) | 0 | New London Submarine Base (CT) | 68 | ? | |
| 1921 | L | Worden HS (MT) | 2 | Forsyth HS (MT) | 28 | ? | |
| 1921 | L | Woreland | 6 | Casper HS (WY) | 83 | ? | |
| 1921 | W | Wray HS (CO) | 21 | Sterling HS (CO) | 0 | ? | |
| 1921 | W | Wyoming | 14 | Colorado School of Mines | 7 | Laramie, WY | |
| 1921 | T | Wyoming | 9 | Denver (CO) | 9 | Denver, CO | |
| 1921 | L | Wyoming | 3 | Utah | 14 | Salt Lake City, UT | |
| 1921 | T | Wyoming | 7 | Colorado St. | 7 | Fort Collins, CO | |
| 1921 | L | Wyoming | 0 | Colorado College | 10 | Laramie, WY | |
| 1921 | L | Wyoming | 3 | Utah St. | 14 | Logan, UT | |
| 1921 | L | Wyoming | 3 | Idaho | 31 | Boise, ID | |
| 1921 | W | Wyoming Seminary (PA) | 50 | 109th Field Artillery | 6 | ? | |
| 1921 | T | Wyoming Seminary (PA) | 6 | Bellefonte Academy (PA) | 6 | ? | |
| 1921 | W | Wyoming Seminary (PA) | 42 | Bethlehem Prep School (PA) | 2 | ? | |
| 1921 | W | Wyoming Seminary (PA) | 35 | Bloomsburg (PA) | 0 | Kingston, PA | |
| 1921 | W | Wyoming Seminary (PA) | 54 | Cascadilla School (NY) | 0 | ? | |
| 1921 | T | Wyoming Seminary (PA) | 0 | Cornell Freshmen (NY) | 0 | ? | |
| 1921 | W | Wyoming Seminary (PA) | 21 | Lycoming (PA) | 0 | ? | |
| 1921 | W | Wyoming Seminary (PA) | 55 | Perkiomen Seminary (PA) | 0 | ? | |
| 1921 | W | Wyoming Seminary B Team (PA) | 13 | Wilkes-Barre HS (PA) | 6 | ? | |
| 1921 | L | Xavier (LA) | 0 | Southern (LA) | 6 | ? | |
| 1921 | W | Xavier (LA) | 6 | Straight (LA) | 0 | ? | |
| 1921 | L | Xavier (OH) | 6 | Centre (KY) | 28 | Cincinnati, OH | |
| 1921 | L | Xavier (OH) | 7 | Creighton (NE) | 14 | Cincinnati, OH | |
| 1921 | W | Xavier (OH) | 13 | Ohio Northern | 0 | Cincinnati, OH | |
| 1921 | W | Xavier (OH) | 49 | Rose-Hulman Tech (IN) | 0 | Cincinnati, OH | |
| 1921 | W | Xavier (OH) | 21 | Charleston (WV) | 7 | Cincinnati, OH | |
| 1921 | W | Xavier (OH) | 28 | John Carroll (OH) | 0 | Cincinnati, OH | |
| 1921 | W | Xavier (OH) | 13 | Dayton (OH) | 0 | Dayton, OH | |
| 1921 | W | Xavier (OH) | 34 | Hanover (IN) | 0 | Hanover, IN | |
| 1921 | W | Xenia Central HS (OH) | 38 | Greenfield HS (OH) | 0 | ? | |
| 1921 | W | Xenia Central HS (OH) | 21 | Hillsboro HS (OH) | 0 | ? | |
| 1921 | W | Xenia Central HS (OH) | 21 | Miamisburg HS (OH) | 0 | ? | |
| 1921 | W | Xenia Central HS (OH) | 34 | Springfield HS (OH) | 0 | ? | |
| 1921 | W | Xenia Central HS (OH) | 16 | Troy HS (OH) | 0 | ? | |
| 1921 | W | Xenia Central HS (OH) | 27 | Washington Court House HS (OH) | 0 | ? | |
| 1921 | W | Xenia Central HS (OH) | 21 | West Alexandria HS (OH) | 7 | ? | |
| 1921 | W | Xenia Central HS (OH) | 19 | Wilmington HS (OH) | 0 | ? | |
| 1921 | W | Xenia Central HS (OH) | 26 | Wilmington HS (OH) | 0 | ? | |
| 1921 | W | Yale (CT) | 14 | Army (NY) | 7 | New Haven, CT | |
| 1921 | W | Yale (CT) | 28 | Bates (ME) | 0 | New Haven, CT | |
| 1921 | W | Yale (CT) | 45 | Brown (RI) | 7 | New Haven, CT | |
| 1921 | L | Yale (CT) | 3 | Harvard (MA) | 10 | Cambridge, MA | |
| 1921 | W | Yale (CT) | 23 | Williams (MA) | 0 | New Haven, CT | |
| 1921 | W | Yale (CT) | 14 | Vermont | 0 | New Haven, CT | |
| 1921 | W | Yale (CT) | 28 | Maryland | 0 | New Haven, CT | |
| 1921 | W | Yale (CT) | 34 | North Carolina | 0 | New Haven, CT | |
| 1921 | W | Yale (CT) | 13 | Princeton (NJ) | 7 | New Haven, CT | |
| 1921 | W | Yale Freshmen (CT) | 33 | Blair Hall (NJ) | 0 | ? | |
| 1921 | L | Yale Freshmen (CT) | 0 | Roxbury School (CT) | 16 | ? | |
| 1921 | W | Yale Freshmen (CT) | 40 | Hotchkiss Academy (CT) | 0 | Lakeville, CT | |
| 1921 | L | Yankton (SD) | 0 | Dakota Wesleyan (SD) | 22 | Yankton, SD | |
| 1921 | W | Yankton (SD) | 7 | Morningside (IA) | 6 | Yankton, SD | |
| 1921 | L | Yankton (SD) | 0 | South Dakota St. | 55 | Yankton, SD | |
| 1921 | W | Yankton (SD) | 28 | Westmar (IA) | 3 | Yankton, SD | |
| 1921 | L | Yankton (SD) | 0 | South Dakota | 28 | Vermillion, SD | |
| 1921 | W | Yankton (SD) | 14 | Si Tanka (SD) | 0 | Huron, SD | |
| 1921 | L | Yankton (SD) | 0 | Northern St. (SD) | 7 | Aberdeen, SD | |
| 1921 | L | Yazoo City HS (MS) | 0 | Jackson HS (MS) | 47 | ? | |
| 1921 | L | Yeagertown HS (PA) | 0 | Huntingdon HS (PA) | 72 | ? | |
| 1921 | L | Yellowstone County HS (WY) | 0 | Sheridan HS (WY) | 74 | ? | |
| 1921 | L | Yonkers HS (NY) | 6 | Columbia Prep | 14 | ? | |
| 1921 | W | Yonkers HS (NY) | 6 | Leonia HS (NJ) | 0 | ? | |
| 1921 | W | Yonkers HS (NY) | 14 | Mamaroneck HS (NY) | 0 | ? | |
| 1921 | L | Yonkers HS (NY) | 6 | Mount Vernon HS (NY) | 21 | ? | |
| 1921 | L | Yonkers HS (NY) | 0 | New Rochelle HS (NY) | 13 | ? | |
| 1921 | T | Yonkers HS (NY) | 0 | Nyack HS (NY) | 0 | ? | |
| 1921 | L | Yonkers HS (NY) | 12 | White Plains HS (NY) | 21 | ? | |
| 1921 | L | Yonkers HS (NY) | 0 | Fordham Prep (NY) | 35 | New York, NY | Fordham Field |
| 1921 | L | York (NE) | 6 | Cotner (NE) | 7 | ? | |
| 1921 | W | York (NE) | 7 | Hastings (NE) | 0 | ? | York Forfeits? |
| 1921 | W | York (NE) | 6 | Midland Lutheran (NE) | 0 | ? | |
| 1921 | L | York (NE) | 0 | Nebraska Wesleyan | 17 | Lincoln, NE | |
| 1921 | W | York (NE) | 16 | Peru St. (NE) | 13 | ? | |
| 1921 | L | York (NE) | 7 | Saint Mary's (KS) | 14 | ? | |
| 1921 | L | York (NE) | 3 | Grand Island College (NE) | 14 | ? | |
| 1921 | L | York (NE) | 6 | Doane (NE) | 10 | Crete, NE | |
| 1921 | L | York HS (PA) | 0 | Coatesville HS (PA) | 14 | ? | |
| 1921 | L | York HS (PA) | 0 | Harrisburg Academy (PA) | 21 | ? | |
| 1921 | L | York HS (PA) | 0 | Lancaster HS (PA) | 21 | ? | |
| 1921 | T | York HS (PA) | 7 | Millersville (PA) | 7 | ? | |
| 1921 | T | Youngstown Rayen HS (OH) | 0 | Akron Central HS (OH) | 0 | ? | |
| 1921 | W | Youngstown Rayen HS (OH) | 10 | Canton McKinley HS (OH) | 7 | ? | |
| 1921 | L | Youngstown Rayen HS (OH) | 0 | East Cleveland Shaw HS (OH) | 6 | ? | |
| 1921 | L | Youngstown Rayen HS (OH) | 0 | Youngstown South HS (OH) | 13 | ? | |
| 1921 | W | Youngstown South HS (OH) | 13 | Akron South HS (OH) | 7 | ? | |
| 1921 | T | Youngstown South HS (OH) | 0 | Ashtabula HS (OH) | 0 | ? | |
| 1921 | T | Youngstown South HS (OH) | 14 | Canton McKinley HS (OH) | 14 | ? | |
| 1921 | W | Youngstown South HS (OH) | 39 | Girard HS (OH) | 0 | ? | |
| 1921 | W | Youngstown South HS (OH) | 48 | Lisbon HS (OH) | 7 | ? | |
| 1921 | L | Youngstown South HS (OH) | 6 | Massillon HS (OH) | 17 | ? | |
| 1921 | W | Youngstown South HS (OH) | 21 | Niles HS (OH) | 6 | ? | |
| 1921 | W | Youngstown South HS (OH) | 7 | Salem HS (OH) | 0 | ? | |
| 1921 | W | Youngstown South HS (OH) | 14 | Warren HS (OH) | 7 | ? | |
| 1921 | W | Youngstown South HS (OH) | 13 | Youngstown Rayen HS (OH) | 0 | ? | |
| 1921 | L | Ypsilanti HS (MI) | 0 | Ann Arbor HS (MI) | 58 | ? | |
| 1921 | L | Ypsilanti HS (MI) | 0 | Detroit Northeastern HS (MI) | 13 | ? | |
| 1921 | L | Ypsilanti HS (MI) | 0 | Detroit Northern HS (MI) | 21 | ? |